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Ana J Coito

Title(s)Professor-in-Residence, Surgery
SchoolMedicine
Phone49480
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    Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    NIH/NIAID R56AI057832Apr 1, 2010 - May 27, 2010
    Role: Principal Investigator
    Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    NIH/NIAID R01AI057832Jan 1, 2004 - Mar 31, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fujii T, Duarte S, Lee E, Ke B, Busuttil RW, Coito AJ. Tissue Inhibitor of Metalloproteinase 3 Deficiency Disrupts the Hepatocyte E-Cadherin/ß-Catenin Complex and Induces Cell Death in Liver Ischemia/Reperfusion Injury. Liver Transpl. 2020 Jan; 26(1):113-126. PMID: 31642174.
      View in: PubMed
    2. Jin Y, Li C, Xu D, Zhu J, Wei S, Zhong A, Sheng M, Duarte S, Coito AJ, Busuttil RW, Xia Q, Kupiec-Weglinski JW, Ke B. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol. 2019 Oct 31. PMID: 31673056.
      View in: PubMed
    3. Kato H, Duarte S, Miller MG, Busuttil RW, Coito AJ. Overproduction of Tenascin-C Driven by Lipid Accumulation in the Liver Aggravates Hepatic Ischemia/Reperfusion Injury in Steatotic Mice. Liver Transpl. 2019 02; 25(2):288-301. PMID: 30358115.
      View in: PubMed
    4. Duarte S, Matian P, Ma S, Busuttil RW, Coito AJ. Adeno-Associated Virus-Mediated Gene Transfer of Tissue Inhibitor of Metalloproteinases-1 Impairs Neutrophil Extracellular Trap Formation and Ameliorates Hepatic Ischemia and Reperfusion Injury. Am J Pathol. 2018 08; 188(8):1820-1832. PMID: 29870740.
      View in: PubMed
    5. Kato H, Duarte S, Liu D, Busuttil RW, Coito AJ. Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice. PLoS One. 2015; 10(9):e0137642. PMID: 26355684.
      View in: PubMed
    6. Duarte S, Kato H, Kuriyama N, Suko K, Ishikawa TO, Busuttil RW, Herschman HR, Coito AJ. Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. PLoS One. 2014; 9(5):e96913. PMID: 24819536.
      View in: PubMed
    7. Kato H, Kuriyama N, Duarte S, Clavien PA, Busuttil RW, Coito AJ. MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury. J Hepatol. 2014 May; 60(5):1032-9. PMID: 24412604.
      View in: PubMed
    8. Duarte S, Hamada T, Kuriyama N, Busuttil RW, Coito AJ. TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury. Hepatology. 2012 Sep; 56(3):1074-85. PMID: 22407827.
      View in: PubMed
    9. Hong JC, Koroleff D, Xia V, Chang CM, Duarte SM, Xu J, Lassman C, Kupiec-Weglinski J, Coito AJ, Busuttil RW. Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. J Am Coll Surg. 2012 Apr; 214(4):505-15; discussion 515-6. PMID: 22321520.
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    10. Kuriyama N, Duarte S, Hamada T, Busuttil RW, Coito AJ. Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury. Hepatology. 2011 Dec; 54(6):2125-36. PMID: 21898491.
      View in: PubMed
    11. Coito AJ. Leukocyte transmigration across endothelial and extracellular matrix protein barriers in liver ischemia/reperfusion injury. Curr Opin Organ Transplant. 2011 Feb; 16(1):34-40. PMID: 21150609.
      View in: PubMed
    12. Hamada T, Duarte S, Tsuchihashi S, Busuttil RW, Coito AJ. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol. 2009 Jun; 174(6):2265-77. PMID: 19443702.
      View in: PubMed
    13. Hamada T, Tsuchihashi S, Avanesyan A, Duarte S, Moore C, Busuttil RW, Coito AJ. Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury. J Immunol. 2008 Feb 01; 180(3):1843-53. PMID: 18209082.
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    14. Hamada T, Fondevila C, Busuttil RW, Coito AJ. Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury. Hepatology. 2008 Jan; 47(1):186-98. PMID: 17880014.
      View in: PubMed
    15. Moore C, Shen XD, Gao F, Busuttil RW, Coito AJ. Fibronectin-alpha4beta1 integrin interactions regulate metalloproteinase-9 expression in steatotic liver ischemia and reperfusion injury. Am J Pathol. 2007 Feb; 170(2):567-77. PMID: 17255325.
      View in: PubMed
    16. Amersi F, Shen XD, Moore C, Melinek J, Busuttil RW, Kupiec-Weglinski JW, Coito AJ. Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury. Am J Pathol. 2003 Apr; 162(4):1229-39. PMID: 12651615.
      View in: PubMed
    17. Blydt-Hansen TD, Katori M, Lassman C, Ke B, Coito AJ, Iyer S, Buelow R, Ettenger R, Busuttil RW, Kupiec-Weglinski JW. Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J Am Soc Nephrol. 2003 Mar; 14(3):745-54. PMID: 12595512.
      View in: PubMed
    18. Anselmo DM, Amersi FF, Shen XD, Gao F, Katori M, Lassman C, Ke B, Coito AJ, Ma J, Brinkmann V, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. Am J Transplant. 2002 Oct; 2(9):843-9. PMID: 12392290.
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    19. Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol. 2002 Aug 01; 169(3):1270-6. PMID: 12133948.
      View in: PubMed
    20. Coito AJ, Shaw GD, Meng L, Moore C, Ma J, Busuttil RW, Kupiec-Weglinski JW. CD62-PSGL-1 interactions regulate cytokine chemokine and apoptotic networks in cardiac allograft recipients. Transplant Proc. 2002 Aug; 34(5):1463-4. PMID: 12176441.
      View in: PubMed
    21. Amersi F, Farmer DG, Shaw GD, Kato H, Coito AJ, Kaldas F, Zhao D, Lassman CR, Melinek J, Ma J, Volk HD, Kupiec-Weglinski JW, Busuttil RW. P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectin molecules protects rat steatotic liver grafts from ischemia/reperfusion injury. Am J Transplant. 2002 Aug; 2(7):600-8. PMID: 12201360.
      View in: PubMed
    22. Coito AJ, Buelow R, Shen XD, Amersi F, Moore C, Volk HD, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation. 2002 Jul 15; 74(1):96-102. PMID: 12134106.
      View in: PubMed
    23. Yuan X, Dong VM, Coito AJ, Waaga AM, Salama AD, Benjamin CD, Sayegh MH, Chandraker A. A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection. Transplantation. 2002 Jun 15; 73(11):1736-42. PMID: 12084995.
      View in: PubMed
    24. Dong VM, Yuan X, Coito AJ, Waaga AM, Sayegh MH, Chandraker A. Mechanisms of targeting CD28 by a signaling monoclonal antibody in acute and chronic allograft rejection. Transplantation. 2002 Apr 27; 73(8):1310-7. PMID: 11981427.
      View in: PubMed
    25. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, Southard D, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation. 2002 Jan 27; 73(2):287-92. PMID: 11821745.
      View in: PubMed
    26. Coito AJ, Shaw GD, Li J, Ke B, Ma J, Busuttil RW, Kupiec-Weglinski JW. Selectin-mediated interactions regulate cytokine networks and macrophage heme oxygenase-1 induction in cardiac allograft recipients. Lab Invest. 2002 Jan; 82(1):61-70. PMID: 11796826.
      View in: PubMed
    27. Coito AJ, Onodera K, Kato H, Busuttil RW, Kupiec-Weglinski JW. Fibronectin-mononuclear cell interactions regulate type 1 helper T cell cytokine network in tolerant transplant recipients. Am J Pathol. 2000 Oct; 157(4):1207-18. PMID: 11021825.
      View in: PubMed
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