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Asim Dasgupta

Title(s)Professor, MIMG
SchoolMedicine
Address609 Charles E. Young Drive, Ea 1602A
Los Angeles CA 90024
Phone3102068649
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of hepatitis C virus 5'untranslated region in virus morphogenesis
    NIH/NIAID R21AI084090May 1, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Towards Developing type 1a HCV cell culture model
    NIH/NIAID R21AI072180Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator
    TRANSLATION INHIBITORS OF HEPATITIS C VIRUS
    NIH/NIAID R41AI045188Sep 30, 1999 - Sep 29, 2000
    Role: Principal Investigator
    TRANSLATION-INHIBITION OF HEPATITIS C AND POLIO VIRUSES
    NIH/NIAID R01AI045733Sep 1, 1999 - Jun 30, 2005
    Role: Principal Investigator
    PICORNAVIRUS TRANSLATION/INHIBITION BY SMALL YEAST RNA
    NIH/NIAID U01AI038056Jul 1, 1995 - Jun 30, 1999
    Role: Principal Investigator
    INHIBITION OF HOST CELL TRANSCRIPTION BY POLIOVIRUS
    NIH/NIAID R01AI027451Feb 1, 1989 - Jan 31, 2005
    Role: Principal Investigator
    IN VITRO REPLICATION OF POLIOVIRUS
    NIH/NIAID R01AI018272Sep 30, 1981 - Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HSP70 Copurifies with Zika Virus Particles. Virology. 2018 09; 522:228-233. Khachatoorian R, Cohn W, Buzzanco A, Riahi R, Arumugaswami V, Dasgupta A, Whitelegge JP, French SW. PMID: 30053656.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Oncoprotein Stathmin Modulates Sensitivity to Apoptosis in Hepatocellular Carcinoma Cells During Hepatitis C Viral Replication. J Cell Death. 2018; 11:1179066018785141. Lu NT, Liu NM, Patel D, Vu JQ, Liu L, Kim CY, Cho P, Khachatoorian R, Patel N, Magyar CE, Ganapathy E, Arumugaswami V, Dasgupta A, French SW. PMID: 30034249.
      View in: PubMed   Mentions:
    3. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents. 2016 Apr; 47(4):289-96. Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. PMID: 27013001.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A. Virology. 2015 Jan 15; 475:46-55. Khachatoorian R, Ruchala P, Waring A, Jung CL, Ganapathy E, Wheatley N, Sundberg C, Arumugaswami V, Dasgupta A, French SW. PMID: 25462345.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle. Virology. 2014 Apr; 454-455:118-27. Khachatoorian R, Ganapathy E, Ahmadieh Y, Wheatley N, Sundberg C, Jung CL, Arumugaswami V, Raychaudhuri S, Dasgupta A, French SW. PMID: 24725938.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle. Virology. 2012 Nov 25; 433(2):346-55. Khachatoorian R, Arumugaswami V, Raychaudhuri S, Yeh GK, Maloney EM, Wang J, Dasgupta A, French SW. PMID: 22975673.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    7. A cell-permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A-mediated translation and virus production. Hepatology. 2012 Jun; 55(6):1662-72. Khachatoorian R, Arumugaswami V, Ruchala P, Raychaudhuri S, Maloney EM, Miao E, Dasgupta A, French SW. PMID: 22183951.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    8. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe. 2011 Apr 21; 9(4):286-98. Morizono K, Xie Y, Olafsen T, Lee B, Dasgupta A, Wu AM, Chen IS. PMID: 21501828.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    9. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3157-62. Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. PMID: 20133606.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    10. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology. 2009 Dec; 50(6):1756-64. Gonzalez O, Fontanes V, Raychaudhuri S, Loo R, Loo J, Arumugaswami V, Sun R, Dasgupta A, French SW. PMID: 19839005.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    11. A cell-permeable peptide inhibits hepatitis C virus replication by sequestering IRES transacting factors. Virology. 2009 Nov 10; 394(1):82-90. Fontanes V, Raychaudhuri S, Dasgupta A. PMID: 19740508.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1. Cancer Res. 2009 Mar 01; 69(5):2057-64. Raychaudhuri S, Fontanes V, Barat B, Dasgupta A. PMID: 19223538.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog. 2008 Oct; 4(10):e1000182. Arumugaswami V, Remenyi R, Kanagavel V, Sue EY, Ngoc Ho T, Liu C, Fontanes V, Dasgupta A, Sun R. PMID: 18927624.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    14. Shutoff of RNA polymerase II transcription by poliovirus involves 3C protease-mediated cleavage of the TATA-binding protein at an alternative site: incomplete shutoff of transcription interferes with efficient viral replication. J Virol. 2005 Aug; 79(15):9702-13. Kundu P, Raychaudhuri S, Tsai W, Dasgupta A. PMID: 16014932.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    15. Effect of heptitis C virus core protein on cellular gene expression: specific inhibition of cyclooxygenase 2. J Infect Dis. 2005 May 01; 191(9):1498-506. Jhaveri R, Kundu P, Shapiro AM, Venkatesan A, Dasgupta A. PMID: 15809909.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Regulation of poliovirus 3C protease by the 2C polypeptide. J Virol. 2004 Sep; 78(17):9243-56. Banerjee R, Weidman MK, Echeverri A, Kundu P, Dasgupta A. PMID: 15308719.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    17. Targeting internal ribosome entry site (IRES)-mediated translation to block hepatitis C and other RNA viruses. FEMS Microbiol Lett. 2004 May 15; 234(2):189-99. Dasgupta A, Das S, Izumi R, Venkatesan A, Barat B. PMID: 15135522.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. A peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation and reveals a single tyrosine critical for La RNA binding and translation stimulation. J Virol. 2004 Apr; 78(7):3763-76. Izumi RE, Das S, Barat B, Raychaudhuri S, Dasgupta A. PMID: 15016896.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    19. Nuclear entry of poliovirus protease-polymerase precursor 3CD: implications for host cell transcription shut-off. Virology. 2004 Mar 15; 320(2):195-205. Sharma R, Raychaudhuri S, Dasgupta A. PMID: 15016543.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    20. Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus. Mol Cell. 2004 Feb 27; 13(4):456-8. Dasgupta A. PMID: 14992716.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. The interaction of cytoplasmic RNA viruses with the nucleus. Virus Res. 2003 Sep; 95(1-2):75-85. Weidman MK, Sharma R, Raychaudhuri S, Kundu P, Tsai W, Dasgupta A. PMID: 12921997.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    22. Cell cycle regulation of hepatitis C and encephalomyocarditis virus internal ribosome entry site-mediated translation in human embryonic kidney 293 cells. Virus Res. 2003 Aug; 94(2):85-95. Venkatesan A, Sharma R, Dasgupta A. PMID: 12902037.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    23. Interaction of picornavirus 2C polypeptide with the viral negative-strand RNA. J Gen Virol. 2001 Nov; 82(Pt 11):2621-2627. Banerjee R, Dasgupta A. PMID: 11602773.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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