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Basil Rapoport

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone(310) 423-4774
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peri-tumor administration of controlled release anti-CTLA-4 synergizes with systemic anti-PD-1 to induce systemic antitumor immunity while sparing autoimmune toxicity. Cancer Immunol Immunother. 2020 Sep; 69(9):1737-1749. Harui A, McLachlan SM, Rapoport B, Zarembinski TI, Roth MD. PMID: 32333082.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. A transgenic mouse that spontaneously develops pathogenic TSH receptor antibodies will facilitate study of antigen-specific immunotherapy for human Graves' disease. Endocrine. 2019 11; 66(2):137-148. McLachlan SM, Rapoport B. PMID: 31560118.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans. Thyroid. 2019 08; 29(8):1138-1146. McLachlan SM, Aliesky HA, Rapoport B. PMID: 31184281.
      View in: PubMed   Mentions: 1     Fields:    
    4. Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice. J Immunol. 2019 05 01; 202(9):2570-2577. McLachlan SM, Aliesky HA, Rapoport B. PMID: 30944161.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    5. To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex-independent) NOD.H2h4 mice. Clin Exp Immunol. 2019 04; 196(1):52-58. McLachlan SM, Aliesky HA, Rapoport B. PMID: 30566234.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Reflections on Thyroid Autoimmunity: A Personal Overview from the Past into the Future. Horm Metab Res. 2018 Dec; 50(12):840-852. Rapoport B, McLachlan SM. PMID: 30357776.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. Thyroid Hemiagenesis in a Thyroiditis Prone Mouse Strain. Eur Thyroid J. 2018 Aug; 7(4):187-192. McLachlan SM, Aliesky HA, Garcia P, Banuelos B, Rapoport B. PMID: 30283736.
      View in: PubMed   Mentions:
    8. Structure of a Thyrotropin Receptor Monoclonal Antibody Variable Region Provides Insight into Potential Mechanisms for its Inverse Agonist Activity. Thyroid. 2018 07; 28(7):933-940. Chen CR, McLachlan SM, Hubbard PA, McNally R, Murali R, Rapoport B. PMID: 29845889.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. A Role for Satb1 in Thyroid Autoimmunity? Thyroid. 2018 05; 28(5):682-683. McLachlan SM, Rapoport B. PMID: 29620973.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Thyroid Autoantibodies Display both "Original Antigenic Sin" and Epitope Spreading. Front Immunol. 2017; 8:1845. McLachlan SM, Rapoport B. PMID: 29326719.
      View in: PubMed   Mentions: 2     Fields:    
    11. Aberrant Iodine Autoregulation Induces Hypothyroidism in a Mouse Strain in the Absence of Thyroid Autoimmunity. J Endocr Soc. 2018 Jan 01; 2(1):63-76. McLachlan SM, Aliesky HA, Rapoport B. PMID: 29379895.
      View in: PubMed   Mentions:
    12. Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies. Endocrinology. 2017 11 01; 158(11):3754-3764. McLachlan SM, Aliesky H, Banuelos B, Hee SSQ, Rapoport B. PMID: 28938453.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    13. Mechanisms of Autoantibody-Induced Pathology. Front Immunol. 2017; 8:603. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. PMID: 28620373.
      View in: PubMed   Mentions: 73     Fields:    
    14. Genes Outside the Major Histocompatibility Complex Locus Are Linked to the Development of Thyroid Autoantibodies and Thyroiditis in NOD.H2h4 Mice. Endocrinology. 2017 04 01; 158(4):702-713. McLachlan SM, Lesage S, Collin R, Banuelos B, Aliesky HA, Rapoport B. PMID: 28323998.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    15. High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies. Clin Exp Immunol. 2017 05; 188(2):243-253. McLachlan SM, Aliesky HA, Banuelos B, Lesage S, Collin R, Rapoport B. PMID: 28099999.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    16. Critical Differences between Induced and Spontaneous Mouse Models of Graves' Disease with Implications for Antigen-Specific Immunotherapy in Humans. J Immunol. 2016 12 15; 197(12):4560-4568. Rapoport B, Banuelos B, Aliesky HA, Hartwig Trier N, McLachlan SM. PMID: 27913646.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    17. TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective. Endocr Rev. 2016 02; 2016(1):23-42. Rapoport B, McLachlan SM. PMID: 27454362.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective. Endocr Rev. 2016 Apr; 37(2):114-34. Rapoport B, McLachlan SM. PMID: 26799472.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells. Endocrinology. 2015 Jul; 156(7):2732-8. Chen CR, Salazar LM, McLachlan SM, Rapoport B. PMID: 25860033.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease. J Clin Endocrinol Metab. 2015 Jun; 100(6):E871-5. Rapoport B, Aliesky HA, Chen CR, McLachlan SM. PMID: 25856215.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. A unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor. J Immunol. 2015 May 01; 194(9):4154-61. Rapoport B, Aliesky HA, Banuelos B, Chen CR, McLachlan SM. PMID: 25825442.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    22. Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis. Mol Endocrinol. 2015 Jan; 29(1):99-107. Chen CR, Hubbard PA, Salazar LM, McLachlan SM, Murali R, Rapoport B. PMID: 25419797.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Graves' hyperthyroidism is antibody-mediated but is predominantly a Th1-type cytokine disease. J Clin Endocrinol Metab. 2014 Nov; 99(11):4060-1. Rapoport B, McLachlan SM. PMID: 25210884.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    24. Immunoglobulin heavy chain variable region and major histocompatibility region genes are linked to induced graves' disease in females from two very large families of recombinant inbred mice. Endocrinology. 2014 Oct; 155(10):4094-103. McLachlan SM, Aliesky H, Banuelos B, Magana J, Williams RW, Rapoport B. PMID: 25051451.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Sex, genetics, and the control of thyroxine and thyrotropin in mice. Thyroid. 2014 Jul; 24(7):1080-7. McLachlan SM, Hamidi S, Aliesky H, Williams RW, Rapoport B. PMID: 24564389.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity. Endocr Rev. 2014 Feb; 35(1):59-105. McLachlan SM, Rapoport B. PMID: 24091783.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    27. Thyroid autoantibodies are rare in nonhuman great apes and hypothyroidism cannot be attributed to thyroid autoimmunity. Endocrinology. 2013 Dec; 154(12):4896-907. Aliesky H, Courtney CL, Rapoport B, McLachlan SM. PMID: 24092641.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Boris Catz, MD (1923-2013). Thyroid. 2013 Jul; 23(7):777-8. Rapoport B. PMID: 23721287.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thyroid. 2013 Mar; 23(3):360-70. Hamidi S, Aliesky HA, Williams RW, Rapoport B, McLachlan SM. PMID: 22988948.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    30. Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa. Thyroid. 2013 Jan; 23(1):14-24. McLachlan SM, Rapoport B. PMID: 23025526.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    31. Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms. Endocrinology. 2013 Jan; 154(1):562-71. Hamidi S, Chen CR, Murali R, McLachlan SM, Rapoport B. PMID: 23183178.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation. Endocrinology. 2012 Oct; 153(10):5058-67. Chen CR, Salazar LM, McLachlan SM, Rapoport B. PMID: 23002040.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    33. Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. PLoS One. 2012; 7(9):e43517. McLachlan SM, Aliesky HA, Chen CR, Chong G, Rapoport B. PMID: 22970131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Role of self-tolerance and chronic stimulation in the long-term persistence of adenovirus-induced thyrotropin receptor antibodies in wild-type and transgenic mice. Thyroid. 2012 Sep; 22(9):931-7. McLachlan SM, Aliesky HA, Chen CR, Rapoport B. PMID: 22827528.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    35. Long term persistence of thyrotropin receptor antibodies in wild-type and transgenic mice in a Graves' disease model. Thyroid. 2012 Apr 10. McLachlan SM, Aliesky H, Chen CR, Rapoport B. PMID: 22489908.
      View in: PubMed   Mentions:    Fields:    
    36. Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor. PLoS One. 2012; 7(2):e31973. Chen CR, Salazar LM, McLachlan SM, Rapoport B. PMID: 22359649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Review and hypothesis: does Graves' disease develop in non-human great apes? Thyroid. 2011 Dec; 21(12):1359-66. McLachlan SM, Alpi K, Rapoport B. PMID: 22066476.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure. Thyroid. 2011 Sep; 21(9):1013-20. Hamidi S, Chen CR, McLachlan SM, Rapoport B. PMID: 21834684.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease. PLoS One. 2011; 6(6):e21378. McLachlan SM, Aliesky HA, Chen CR, Williams RW, Rapoport B. PMID: 21738647.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    40. An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens. Thyroid. 2011 Jul; 21(7):773-81. Chen CR, Aliesky HA, Rapoport B, McLachlan SM. PMID: 21649471.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    41. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology. 2011 Mar; 152(3):1172-9. McLachlan SM, Lu L, Aliesky HA, Williams RW, Rapoport B. PMID: 21209025.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    42. Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain. J Biol Chem. 2011 Feb 25; 286(8):6219-24. Chen CR, McLachlan SM, Rapoport B. PMID: 21190937.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    43. Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function. Mol Endocrinol. 2011 Jan; 25(1):184-94. Hamidi S, Chen CR, Mizutori-Sasai Y, McLachlan SM, Rapoport B. PMID: 21106880.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity. Thyroid. 2010 Nov; 20(11):1307-14. Nishihara E, Chen CR, Higashiyama T, Mizutori-Sasai Y, Ito M, Kubota S, Amino N, Miyauchi A, Rapoport B. PMID: 20929407.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water. Thyroid. 2010 Oct; 20(10):1157-62. Hamidi S, Aliesky H, Chen CR, Rapoport B, McLachlan SM. PMID: 20860425.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    46. Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies. Endocrinology. 2010 Sep; 151(9):4583-93. Chen CR, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee C, Aliesky HA, Rapoport B, McLachlan SM. PMID: 20573721.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    47. Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice. Endocrinology. 2010 Aug; 151(8):4047-54. Nakahara M, Mitsutake N, Sakamoto H, Chen CR, Rapoport B, McLachlan SM, Nagayama Y. PMID: 20555026.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred mice. Genes Immun. 2010 Apr; 11(3):254-63. Rapoport B, Williams RW, Chen CR, McLachlan SM. PMID: 20407472.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation. Endocrinology. 2010 Apr; 151(4):1940-7. Chen CR, McLachlan SM, Rapoport B. PMID: 20181794.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    50. Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice. Thyroid. 2009 May; 19(5):503-9. Misharin AV, Rapoport B, McLachlan SM. PMID: 19348579.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    51. Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies. Endocrinology. 2009 Aug; 150(8):3944-52. Misharin AV, Nagayama Y, Aliesky HA, Mizutori Y, Rapoport B, McLachlan SM. PMID: 19389831.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    52. A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain. Endocrinology. 2009 Jul; 150(7):3401-8. Chen CR, McLachlan SM, Rapoport B. PMID: 19299457.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens. Endocrinology. 2009 Jun; 150(6):2948-56. Misharin AV, Nagayama Y, Aliesky HA, Rapoport B, McLachlan SM. PMID: 19264867.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    54. Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease. J Clin Endocrinol Metab. 2009 Mar; 94(3):927-35. Mizutori Y, Chen CR, Latrofa F, McLachlan SM, Rapoport B. PMID: 19066298.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    55. Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology. 2009 Feb; 150(2):1051-60. Misharin A, Hewison M, Chen CR, Lagishetty V, Aliesky HA, Mizutori Y, Rapoport B, McLachlan SM. PMID: 18927213.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    56. Role of the transgenic human thyrotropin receptor A-subunit in thyroiditis induced by A-subunit immunization and regulatory T cell depletion. Clin Exp Immunol. 2008 Dec; 154(3):305-15. Mizutori Y, Nagayama Y, Flower D, Misharin A, Aliesky HA, Rapoport B, McLachlan SM. PMID: 18811696.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    57. Whither TSH receptor blocking antibodies in the treatment of Graves' disease? Thyroid. 2008 Jul; 18(7):695-6. Rapoport B, McLachlan SM. PMID: 18630996.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    58. Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology. 2008 Jul; 149(7):3427-34. Chen CR, McLachlan SM, Rapoport B. PMID: 18388191.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    59. Thyroid peroxidase autoantibody epitopes revisited*. Clin Endocrinol (Oxf). 2008 Oct; 69(4):526-7. McLachlan SM, Rapoport B. PMID: 18363887.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    60. The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. Mol Endocrinol. 2008 May; 22(5):1171-82. Mizutori Y, Chen CR, McLachlan SM, Rapoport B. PMID: 18218728.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    61. Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice. Endocrinology. 2008 Apr; 149(4):2001-9. McLachlan SM, Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B. PMID: 18162518.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    62. Thyroid peroxidase as an autoantigen. Thyroid. 2007 Oct; 17(10):939-48. McLachlan SM, Rapoport B. PMID: 17822378.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    63. The thyrotropin receptor in Graves' disease. Thyroid. 2007 Oct; 17(10):911-22. Rapoport B, McLachlan SM. PMID: 17822379.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    64. Half a century after the discovery of thyroid autoimmunity: the impact of molecular biology. Thyroid. 2007 Oct; 17(10):909-10. Rapoport B, McLachlan S. PMID: 17983330.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    65. The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinology. 2007 Dec; 148(12):5724-33. McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A, Aliesky HA, Rapoport B. PMID: 17823263.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    66. Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity. Endocrinology. 2007 May; 148(5):2375-82. Chen CR, McLachlan SM, Rapoport B. PMID: 17272389.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    67. HLA-DR3 transgenic mice immunized with adenovirus encoding the thyrotropin receptor: T cell epitopes and functional analysis of the CD40 Graves' polymorphism. Thyroid. 2006 Dec; 16(12):1221-7. Pichurin P, Pham N, David CS, Rapoport B, McLachlan SM. PMID: 17199432.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    68. Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus. Thyroid. 2006 May; 16(5):427-34. Chen CR, Aliesky HA, Guo J, Rapoport B, McLachlan SM. PMID: 16756463.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    69. Antibodies focused on the human autoantibody immunodominant region are induced by B lymphocytes that constitutively express thyroid peroxidase diverted to the major histocompatibility complex II pathway. Thyroid. 2006 Apr; 16(4):343-9. Guo J, McLachlan SM, Rapoport B. PMID: 16646679.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    70. Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology. 2006 Jun; 147(6):2789-800. Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM. PMID: 16543368.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    71. Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface. Endocrinology. 2006 Jun; 147(6):3107-13. Chen CR, Chazenbalk GD, Wawrowsky KA, McLachlan SM, Rapoport B. PMID: 16497802.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    72. Targeted expression of the human thyrotropin receptor A-subunit to the mouse thyroid: insight into overcoming the lack of response to A-subunit adenovirus immunization. J Immunol. 2006 Jan 01; 176(1):668-76. Pichurin PN, Chen CR, Chazenbalk GD, Aliesky H, Pham N, Rapoport B, McLachlan SM. PMID: 16365463.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    73. Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease. Immunology. 2005 Dec; 116(4):532-40. Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA. PMID: 16313367.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    74. Gene expression profiles differ markedly in mouse strains that are (or are not) susceptible to hyperthyroidism induced using thyrotropin receptor-expressing adenovirus. Thyroid. 2005 Nov; 15(11):1229-37. Chen CR, Abbud R, Wang C, Tan Y, Rapoport B, McLachlan SM. PMID: 16356085.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    75. Relationship between thyroid peroxidase T cell epitope restriction and antibody recognition of the autoantibody immunodominant region in human leukocyte antigen DR3 transgenic mice. Endocrinology. 2005 Nov; 146(11):4961-7. Guo J, McLachlan SM, Pichurin PN, Chen CR, Pham N, Aliesky HA, David CS, Rapoport B. PMID: 16081633.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    76. Insight into Graves' hyperthyroidism from animal models. Endocr Rev. 2005 Oct; 26(6):800-32. McLachlan SM, Nagayama Y, Rapoport B. PMID: 15827111.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    77. Interactions between the mannose receptor and thyroid autoantigens. Clin Exp Immunol. 2005 Feb; 139(2):216-24. Chazenbalk GD, Pichurin PN, Guo J, Rapoport B, McLachlan SM. PMID: 15654820.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    78. Human autoantibodies modulate the T cell epitope repertoire but fail to unmask a pathogenic cryptic epitope. J Immunol. 2005 Jan 01; 174(1):557-63. Quaratino S, Ruf J, Osman M, Guo J, McLachlan S, Rapoport B, Londei M. PMID: 15611283.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    79. Human monoclonal thyroglobulin autoantibodies: epitopes and immunoglobulin genes. J Clin Endocrinol Metab. 2004 Oct; 89(10):5116-23. Latrofa F, Phillips M, Rapoport B, McLachlan SM. PMID: 15472215.
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    80. Evidence that the thyrotropin receptor protease is membrane-associated and is not within lipid rafts. Thyroid. 2004 Oct; 14(10):801-5. Latrofa F, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 15588374.
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    81. Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice. Endocrinology. 2005 Jan; 146(1):294-300. McLachlan SM, Braley-Mullen H, Chen CR, Aliesky H, Pichurin PN, Rapoport B. PMID: 15459116.
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    82. Affinity-enrichment of thyrotropin receptor autoantibodies from Graves' patients and normal individuals provides insight into their properties and possible origin from natural antibodies. J Clin Endocrinol Metab. 2004 Sep; 89(9):4734-45. Latrofa F, Chazenbalk GD, Pichurin P, Chen CR, McLachlan SM, Rapoport B. PMID: 15356088.
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    83. Autoimmune hypothyroidism: T cells caught in the act. Nat Med. 2004 Sep; 10(9):895-6. McLachlan SM, Rapoport B. PMID: 15340407.
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    84. "Hijacking" the thyrotropin receptor: A chimeric receptor-lysosome associated membrane protein enhances deoxyribonucleic acid vaccination and induces Graves' hyperthyroidism. Endocrinology. 2004 Dec; 145(12):5504-14. Pichurin PN, Chazenbalk GD, Aliesky H, Pichurina O, Rapoport B, McLachlan SM. PMID: 15331574.
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    85. Graves' hyperthyroidism and the hygiene hypothesis in a mouse model. Endocrinology. 2004 Nov; 145(11):5075-9. Nagayama Y, McLachlan SM, Rapoport B, Oishi K. PMID: 15308620.
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    86. Schistosoma mansoni and alpha-galactosylceramide: prophylactic effect of Th1 Immune suppression in a mouse model of Graves' hyperthyroidism. J Immunol. 2004 Aug 01; 173(3):2167-73. Nagayama Y, Watanabe K, Niwa M, McLachlan SM, Rapoport B. PMID: 15265954.
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    87. Susceptibility rather than resistance to hyperthyroidism is dominant in a thyrotropin receptor adenovirus-induced animal model of Graves' disease as revealed by BALB/c-C57BL/6 hybrid mice. Endocrinology. 2004 Nov; 145(11):4927-33. Chen CR, Aliesky H, Pichurin PN, Nagayama Y, McLachlan SM, Rapoport B. PMID: 15284197.
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    88. Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies? Thyroid. 2004 Jul; 14(7):510-20. McLachlan SM, Rapoport B. PMID: 15307940.
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    89. Thyroid stimulating monoclonal antibodies: overcoming the road blocks and the way forward. Clin Endocrinol (Oxf). 2004 Jul; 61(1):10-8. McLachlan SM, Rapoport B. PMID: 15212639.
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    90. Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies. J Biol Chem. 2004 Sep 10; 279(37):39058-67. Bresson D, Pugnière M, Roquet F, Rebuffat SA, N-Guyen B, Cerutti M, Guo J, McLachlan SM, Rapoport B, Estienne V, Ruf J, Chardès T, Péraldi-Roux S. PMID: 15150267.
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    91. Naked deoxyribonucleic acid vaccination induces recognition of diverse thyroid peroxidase T cell epitopes. Endocrinology. 2004 Aug; 145(8):3671-8. Guo J, Pichurin PN, Morris JC, Rapoport B, McLachlan SM. PMID: 15123538.
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    92. Thyroid stimulation does not require antibodies with identical epitopes but does involve recognition of a critical conformation at the N terminus of the thyrotropin receptor A-subunit. J Clin Endocrinol Metab. 2004 Apr; 89(4):1788-93. Chazenbalk GD, Latrofa F, McLachlan SM, Rapoport B. PMID: 15070946.
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    93. Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease. Clin Exp Immunol. 2004 Mar; 135(3):391-7. Pichurin PN, Chen CR, Nagayama Y, Pichurina O, Rapoport B, McLachlan SM. PMID: 15008970.
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    94. Thyrotrophin receptor-specific memory T cell responses require normal B cells in a murine model of Graves' disease. Clin Exp Immunol. 2003 Dec; 134(3):396-402. Pichurin P, Aliesky H, Chen CR, Nagayama Y, Rapoport B, McLachlan SM. PMID: 14632743.
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    95. Thyrotropin receptor knockout mice: studies on immunological tolerance to a major thyroid autoantigen. Endocrinology. 2004 Mar; 145(3):1294-301. Pichurin PN, Pichurina O, Marians RC, Chen CR, Davies TF, Rapoport B, McLachlan SM. PMID: 14630711.
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    96. Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease. Endocrinology. 2004 Jan; 145(1):228-33. Chen CR, Pichurin P, Chazenbalk GD, Aliesky H, Nagayama Y, McLachlan SM, Rapoport B. PMID: 14576177.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    97. Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. Thyroid. 2003 Oct; 13(10):911-7. Pichurin P, Chen CR, Pichurina O, David C, Rapoport B, McLachlan SM. PMID: 14611699.
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    98. Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity. Endocrinology. 2003 Sep; 144(9):3821-7. Chen CR, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 12933653.
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    99. Does thyrotropin cleave its cognate receptor? Endocrinology. 2004 Jan; 145(1):4-10. Chazenbalk GD, Chen CR, McLachlan SM, Rapoport B. PMID: 12960016.
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    100. Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. Clin Exp Immunol. 2003 Jun; 132(3):408-15. Guo J, Pichurin P, Nagayama Y, Rapoport B, McLachlan SM. PMID: 12780686.
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    101. The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim. J Clin Invest. 2003 Jun; 111(12):1897-904. Chen CR, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM. PMID: 12813025.
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    102. The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors. Endocrinology. 2003 May; 144(5):1718-25. Schwarz-Lauer L, Pichurin PN, Chen CR, Nagayama Y, Paras C, Morris JC, Rapoport B, McLachlan SM. PMID: 12697676.
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    103. Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine. J Immunol. 2003 Apr 01; 170(7):3522-7. Nagayama Y, Mizuguchi H, Hayakawa T, Niwa M, McLachlan SM, Rapoport B. PMID: 12646613.
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    104. Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity. Endocrinology. 2003 Apr; 144(4):1324-30. Chen CR, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 12639915.
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    105. A major role for non-major histocompatibility complex genes but not for microorganisms in a novel murine model of Graves' hyperthyroidism. Thyroid. 2003 Mar; 13(3):233-8. Nagayama Y, McLachlan SM, Rapoport B, Niwa M. PMID: 12729471.
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    106. Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies. J Clin Endocrinol Metab. 2003 Jan; 88(1):371-8. Latrofa F, Pichurin P, Guo J, Rapoport B, McLachlan SM. PMID: 12519879.
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    107. Evidence that the complement control protein-epidermal growth factor-like domain of thyroid peroxidase lies on the fringe of the immunodominant region recognized by autoantibodies. Thyroid. 2002 Dec; 12(12):1085-95. Pichurin PN, Guo J, Estienne V, Carayon P, Ruf J, Rapoport B, McLachlan SM. PMID: 12593722.
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    108. Peptide scanning for thyrotropin receptor T-cell epitopes in mice vaccinated with naked DNA. Thyroid. 2002 Sep; 12(9):755-64. Pichurin P, Schwarz-Lauer L, Braley-Mullen H, Paras C, Pichurina O, Morris JC, Rapoport B, McLachlan SM. PMID: 12481940.
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    109. Localization of the thyroid peroxidase autoantibody immunodominant region to a junctional region containing portions of the domains homologous to complement control protein and myeloperoxidase. J Biol Chem. 2002 Oct 25; 277(43):40189-95. Guo J, McLachlan SM, Rapoport B. PMID: 12167622.
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    110. Human thyroperoxidase folds in one complex B-cell immunodominant region. Biochem Biophys Res Commun. 2002 Aug 02; 295(5):1118-24. Blanchin S, Estienne V, Guo J, Rapoport B, McLachlan SM, Carayon P, Ruf J. PMID: 12135610.
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    111. Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. J Clin Invest. 2002 Jul; 110(2):209-17. Chazenbalk GD, Pichurin P, Chen CR, Latrofa F, Johnstone AP, McLachlan SM, Rapoport B. PMID: 12122113.
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    112. Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination. Endocrinology. 2002 Apr; 143(4):1182-9. Pichurin P, Pichurina O, Chazenbalk GD, Paras C, Chen CR, Rapoport B, McLachlan SM. PMID: 11897670.
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    113. Immune Deviation Away from Th1 in Interferon-? Knockout Mice Does Not Enhance TSH Receptor Antibody Production after Naked DNA Vaccination. Endocrinology. 2002 Apr 01; 143(4):1182-1189. Pichurin P, Pichurina O, Chazenbalk GD, Paras C, Chen CR, Rapoport B, McLachlan SM. PMID: 28204436.
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    114. Thyroid autoimmunity. J Clin Invest. 2001 Nov; 108(9):1253-9. Rapoport B, McLachlan SM. PMID: 11696565.
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    115. Naked TSH receptor DNA vaccination: A TH1 T cell response in which interferon-gamma production, rather than antibody, dominates the immune response in mice. Endocrinology. 2001 Aug; 142(8):3530-6. Pichurin P, Yan XM, Farilla L, Guo J, Chazenbalk GD, Rapoport B, McLachlan SM. PMID: 11459799.
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    116. Human monoclonal autoantibodies to B-cell epitopes outside the thyroid peroxidase autoantibody immunodominant region. Thyroid. 2001 Apr; 11(4):301-13. Pichurin P, Guo J, Yan X, Rapoport B, McLachlan SM. PMID: 11349828.
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    117. Insight into thyrotropin receptor cleavage by engineering the single polypeptide chain luteinizing hormone receptor into a cleaving, two subunit receptor. Eur J Biochem. 2001 Apr; 268(8):2261-9. Chazenbalk GD, McLachlan SM, Chen CR, Rapoport B. PMID: 11298743.
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    118. A prion-like shift between two conformational forms of a recombinant thyrotropin receptor A-subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies. J Clin Endocrinol Metab. 2001 Mar; 86(3):1287-93. Chazenbalk GD, McLachlan SM, Pichurin P, Yan XM, Rapoport B. PMID: 11238522.
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    119. Does the autoantibody immunodominant region on thyroid peroxidase include amino acid residues 742-771? Thyroid. 2001 Mar; 11(3):227-31. Xiong Z, Farilla L, Guo J, McLachlan S, Rapoport B. PMID: 11327613.
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    120. A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain. J Biol Chem. 2001 May 04; 276(18):14767-72. Chen CR, Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 11278376.
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    121. Reassessment of the location of the thyrotropin receptor 50 amino acid "insertion" provides evidence in favor of a second downstream cleavage site. Thyroid. 2001 Feb; 11(2):111-4. Tanaka K, Chazenbalk GD, Rapoport B, McLachlan SM. PMID: 11288979.
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    122. Search for the autoantibody immunodominant region on thyroid peroxidase: epitopic footprinting with a human monoclonal autoantibody locates a facet on the native antigen containing a highly conformational epitope. J Immunol. 2001 Jan 15; 166(2):1327-33. Guo J, Yan XM, McLachlan SM, Rapoport B. PMID: 11145717.
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    123. Cytokines, IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts co-expressing MHC class II and thyroid autoantigens. Clin Exp Immunol. 2000 Nov; 122(2):170-9. Yan XM, Guo J, Pichurin P, Tanaka K, Jaume JC, Rapoport B, McLachlan SM. PMID: 11091271.
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    124. Presence of interleukin 4 or interleukin 10, but not both cytokines, in pancreatic tissue of two patients with recently diagnosed diabetes mellitus type I. Autoimmunity. 2000 Oct; 32(3):161-6. Farilla L, Dotta F, Di Mario U, Rapoport B, McLachlan SM. PMID: 11092695.
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    125. Evidence that cleavage of the thyrotropin receptor involves a "molecular ruler" mechanism: deletion of amino acid residues 305-320 causes a spatial shift in cleavage site 1 independent of amino acid motif. Endocrinology. 2000 Oct; 141(10):3573-7. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 11014210.
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    126. Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. Thyroid. 2000 Aug; 10(8):685-92. Rapoport B, Alsabeh R, Aftergood D, McLachlan SM. PMID: 11014313.
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    127. Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II. Clin Exp Immunol. 2000 Jan; 119(1):38-46. Guo J, Wang Y, Rapoport B, McLachlan SM. PMID: 10606962.
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    128. Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator. Int Rev Immunol. 2000; 19(6):587-618. McLachlan SM, Rapoport B. PMID: 11129117.
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    129. Subunit structure of thyrotropin receptors expressed on the cell surface. J Biol Chem. 1999 Nov 26; 274(48):33979-84. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 10567361.
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    130. A direct binding assay for thyrotropin receptor autoantibodies. Thyroid. 1999 Nov; 9(11):1057-61. Chazenbalk GD, Pichurin P, McLachlan SM, Rapoport B. PMID: 10595452.
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    131. On the functional importance of thyrotropin receptor intramolecular cleavage. Endocrinology. 1999 Oct; 140(10):4516-20. Chazenbalk GD, Tanaka K, McLachlan SM, Rapoport B. PMID: 10499506.
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    132. Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region. Clin Exp Immunol. 1999 Jul; 117(1):19-29. Guo J, Wang Y, Jaume JC, Rapoport B, McLachlan SM. PMID: 10403911.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    133. Cellular thyroid peroxidase (TPO), unlike purified TPO and adjuvant, induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease. J Clin Endocrinol Metab. 1999 May; 84(5):1651-7. Jaume JC, Guo J, Wang Y, Rapoport B, McLachlan SM. PMID: 10323395.
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    134. The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit. Mol Cell Endocrinol. 1999 Apr 25; 150(1-2):113-9. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 10411305.
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    135. Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints". J Clin Endocrinol Metab. 1999 Apr; 84(4):1424-31. Jaume JC, Guo J, Pauls DL, Zakarija M, McKenzie JM, Egeland JA, Burek CL, Rose NR, Hoffman WH, Rapoport B, McLachlan SM. PMID: 10199790.
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    136. A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies. J Clin Endocrinol Metab. 1999 Feb; 84(2):702-10. Chazenbalk GD, Wang Y, Guo J, Hutchison JS, Segal D, Jaume JC, McLachlan SM, Rapoport B. PMID: 10022441.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    137. Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion. J Biol Chem. 1999 Jan 22; 274(4):2093-6. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B. PMID: 9890969.
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    138. Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro. Autoimmunity. 1999; 30(1):1-9. Guo J, Rapoport B, McLachlan SM. PMID: 10433089.
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