Bibo Ke

Title(s)Professor-in-Residence, Surgery
SchoolMedicine
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    CD47-SIRPalpha Signaling in Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Transplant Inflammatory Injury
    NIH R21AI146742Jun 11, 2019 - May 31, 2021
    Role: Principal Investigator
    Innate Immune Regulation by HSF1 in Liver Inflammatory Injury
    NIH R01AI139552Jan 25, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Immune Regulation by Stem Cells: Role of Beta-Catenin in Liver Inflammatory Injury
    NIH R21AI115133Aug 17, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Beta-Catenin Signaling in Liver Ischemia and Reperfusion Injury
    NIH R21AI112722Jul 15, 2014 - Jun 30, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression. Exp Mol Med. 2024 Aug 09. Xu D, Qu X, Yang T, Sheng M, Bian X, Zhan Y, Tian Y, Lin Y, Jin Y, Wang X, Ke M, Jiang L, Li C, Xia Q, Farmer DG, Ke B. PMID: 39122845.
      View in: PubMed   Mentions:    Fields:    
    2. The macrophage STING-YAP axis controls hepatic steatosis by promoting the autophagic degradation of lipid droplets. Hepatology. 2023 Oct 23. Yang T, Qu X, Wang X, Xu D, Sheng M, Lin Y, Ke M, Song C, Xia Q, Jiang L, Li J, Farmer DG, Ke B. PMID: 37870294; PMCID: PMC11035483.
      View in: PubMed   Mentions: 2     Fields:    
    3. Macrophage RIPK3 triggers inflammation and cell death via the XBP1-Foxo1 axis in liver ischaemia-reperfusion injury. JHEP Rep. 2023 Nov; 5(11):100879. Qu X, Yang T, Wang X, Xu D, Yu Y, Li J, Jiang L, Xia Q, Farmer DG, Ke B. PMID: 37841640; PMCID: PMC10568422.
      View in: PubMed   Mentions:
    4. Behavioural activity pattern, genetic factors, and the risk of nonalcoholic fatty liver disease: A prospective study in the UK Biobank. Liver Int. 2023 06; 43(6):1287-1297. Ge X, Wang X, Yan Y, Zhang L, Yu C, Lu J, Xu X, Gao J, Liu M, Jiang T, Ke B, Song C. PMID: 37088982.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Editorial: The role of immune cells in hepatic ischemia reperfusion. Front Immunol. 2022; 13:1075984. Ke B, Dai H, Wei Q, Guo Z, Qiu T. PMID: 36405704; PMCID: PMC9672837.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death. JHEP Rep. 2022 Sep; 4(9):100532. Zhan Y, Xu D, Tian Y, Qu X, Sheng M, Lin Y, Ke M, Jiang L, Xia Q, Kaldas FM, Farmer DG, Ke B. PMID: 36035360; PMCID: PMC9404660.
      View in: PubMed   Mentions: 14  
    7. CD47-Mediated Hedgehog/SMO/GLI1 Signaling Promotes Mesenchymal Stem Cell Immunomodulation in Mouse Liver Inflammation. Hepatology. 2021 09; 74(3):1560-1577. Sheng M, Lin Y, Xu D, Tian Y, Zhan Y, Li C, Farmer DG, Kupiec-Weglinski JW, Ke B. PMID: 33765345; PMCID: PMC9436023.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    8. The cGAS-STING Pathway: Novel Perspectives in Liver Diseases. Front Immunol. 2021; 12:682736. Xu D, Tian Y, Xia Q, Ke B. PMID: 33995425; PMCID: PMC8117096.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    9. Functional crosstalk between myeloid Foxo1-β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response. Cell Death Differ. 2021 05; 28(5):1705-1719. Li C, Sheng M, Lin Y, Xu D, Tian Y, Zhan Y, Jiang L, Coito AJ, Busuttil RW, Farmer DG, Kupiec-Weglinski JW, Ke B. PMID: 33288903; PMCID: PMC8167164.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    10. Tissue Inhibitor of Metalloproteinase 3 Deficiency Disrupts the Hepatocyte E-Cadherin/β-Catenin Complex and Induces Cell Death in Liver Ischemia/Reperfusion Injury. Liver Transpl. 2020 01; 26(1):113-126. Fujii T, Duarte S, Lee E, Ke B, Busuttil RW, Coito AJ. PMID: 31642174.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol. 2020 12; 17(12):1245-1256. Jin Y, Li C, Xu D, Zhu J, Wei S, Zhong A, Sheng M, Duarte S, Coito AJ, Busuttil RW, Xia Q, Kupiec-Weglinski JW, Ke B. PMID: 31673056; PMCID: PMC7784844.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury. Front Immunol. 2019; 10:1612. Zhou M, Fang H, Du M, Li C, Tang R, Liu H, Gao Z, Ji Z, Ke B, Chen XL. PMID: 31402909; PMCID: PMC6669370.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    13. Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury. Hepatology. 2019 11; 70(5):1714-1731. Li C, Jin Y, Wei S, Sun Y, Jiang L, Zhu Q, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Ke B. PMID: 31063235; PMCID: PMC6819196.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    14. Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside. Am J Transplant. 2019 02; 19(2):356-367. Kageyama S, Hirao H, Nakamura K, Ke B, Zhang M, Ito T, Aziz A, Oncel D, Kaldas FM, Busuttil RW, Sosa RA, Reed EF, Araujo JA, Kupiec-Weglinski JW. PMID: 30059195; PMCID: PMC6349504.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Reply to: "Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non parenchymal cells?" J Hepatol. 2018 09; 69(3):753-755. Nakamura K, Zhang M, Kageyama S, Ke B, Araujo JA, Kupiec-Weglinski JW. PMID: 29870762.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Lipid Metabolites: The Alarm Signal to Trigger Liver Ischemia-reperfusion Injury. Transplantation. 2018 06; 102(6):887-889. Ke B, Kupiec-Weglinski JW. PMID: 29782474.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology. 2018 07; 68(1):258-273. Kageyama S, Nakamura K, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. PMID: 29350771; PMCID: PMC6033647.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    18. Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation. Am J Transplant. 2018 07; 18(7):1755-1763. Kageyama S, Nakamura K, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 29464890; PMCID: PMC6035063.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers. Hepatology. 2018 03; 67(3):1041-1055. Lu L, Yue S, Jiang L, Li C, Zhu Q, Ke M, Lu H, Wang X, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Ke B. PMID: 29024000; PMCID: PMC5826840.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    20. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human. Am J Transplant. 2018 05; 18(5):1110-1121. Nakamura K, Kageyama S, Yue S, Huang J, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. PMID: 29136322; PMCID: PMC5910267.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    21. Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human. Liver Transpl. 2017 10; 23(10):1282-1293. Nakamura K, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. PMID: 28719070; PMCID: PMC5705033.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    22. Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury. J Hepatol. 2017 12; 67(6):1232-1242. Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. PMID: 28842295; PMCID: PMC5884687.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    23. Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury. Liver Transpl. 2017 06; 23(6):813-825. Zhu Q, Li C, Wang K, Yue S, Jiang L, Ke M, Busuttil RW, Kupiec-Weglinski JW, Zhang F, Lu L, Ke B. PMID: 28152578; PMCID: PMC5449221.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    24. Blockade of Notch signaling promotes acetaminophen-induced liver injury. Immunol Res. 2017 06; 65(3):739-749. Jiang L, Ke M, Yue S, Xiao W, Yan Y, Deng X, Ying QL, Li J, Ke B. PMID: 28286920; PMCID: PMC5464368.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. Thrombomodulin, a Novel Immune Regulator in Liver Inflammatory Injury? Am J Transplant. 2017 01; 17(1):7-8. Ke B. PMID: 27581758.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    26. The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury. Hepatology. 2016 11; 64(5):1683-1698. Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B. PMID: 27474884; PMCID: PMC5074868.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    27. Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network. Transplantation. 2014 Oct 15; 98(7):721-8. Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. PMID: 25171655; PMCID: PMC4188703.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury. Mol Med. 2014 Oct 14; 20:448-55. Huang J, Shen XD, Yue S, Zhu J, Gao F, Zhai Y, Busuttil RW, Ke B, Kupiec-Weglinski JW. PMID: 25014792; PMCID: PMC4212016.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    29. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013 Dec; 59(6):1200-7. Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. PMID: 23867319; PMCID: PMC4524560.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    30. ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology. 2013 Jul; 58(1):351-62. Kamo N, Ke B, Ghaffari AA, Shen XD, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 23408710; PMCID: PMC3679353.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    31. β-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury. Hepatology. 2013 Mar; 57(3):1203-14. Ke B, Shen XD, Kamo N, Ji H, Yue S, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 23081841; PMCID: PMC3594407.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    32. PTEN-mediated Akt/β-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury. Hepatology. 2013 Jan; 57(1):289-98. Kamo N, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 22807038; PMCID: PMC3524373.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    33. Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice. Liver Transpl. 2012 Jun; 18(6):659-70. Ji H, Shen XD, Zhang Y, Gao F, Huang CY, Chang WW, Lee C, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 22290937; PMCID: PMC4186257.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    34. Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice. Surgery. 2012 Nov; 152(5):843-50. Watson MJ, Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 22575884.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    35. Disruption of Type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism. Am J Transplant. 2012 Jul; 12(7):1730-9. Shen XD, Ke B, Ji H, Gao F, Freitas MC, Chang WW, Lee C, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. PMID: 22429450; PMCID: PMC3618475.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    36. Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov; 11(11):2499-507. Kamo N, Shen XD, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 21883905; PMCID: PMC3625141.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling. J Hepatol. 2012 Feb; 56(2):359-66. Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW, Kupiec-Weglinski JW. PMID: 21756853; PMCID: PMC3444295.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    38. Interleukin-13 protects mouse intestine from ischemia and reperfusion injury through regulation of innate and adaptive immunity. Transplantation. 2011 Apr 15; 91(7):737-43. Farmer DG, Ke B, Shen XD, Kaldas FM, Gao F, Watson MJ, Busuttil RW, Kupiec-Weglinski JW. PMID: 21311412; PMCID: PMC3954827.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    39. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011 Feb; 17(2):201-10. Shen XD, Ke B, Uchida Y, Ji H, Gao F, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. PMID: 21280193; PMCID: PMC3058297.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    40. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010 Oct; 52(4):1380-9. Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 20815020; PMCID: PMC2947605.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    41. T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology. 2010 Dec; 139(6):2195-206. Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW. PMID: 20637206; PMCID: PMC2970711.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    42. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transpl. 2010 May; 16(5):600-10. Freitas MC, Uchida Y, Zhao D, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 20440769; PMCID: PMC3001321.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    43. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology. 2010 Apr; 51(4):1363-72. Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW. PMID: 20091883; PMCID: PMC3066468.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    44. Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury. Mol Ther. 2010 May; 18(5):1019-25. Ke B, Shen XD, Gao F, Ji H, Qiao B, Zhai Y, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. PMID: 20029397; PMCID: PMC2890105.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    45. Small interfering RNA targeting heme oxygenase-1 (HO-1) reinforces liver apoptosis induced by ischemia-reperfusion injury in mice: HO-1 is necessary for cytoprotection. Hum Gene Ther. 2009 Oct; 20(10):1133-42. Ke B, Shen XD, Gao F, Qiao B, Ji H, Busuttil RW, Volk HD, Kupiec-Weglinski JW. PMID: 19534599; PMCID: PMC2829285.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    46. Intestinal ischemia/reperfusion injury triggers activation of innate toll-like receptor 4 and adaptive chemokine programs. Transplant Proc. 2008 Dec; 40(10):3339-41. Watson MJ, Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 19100385; PMCID: PMC2975481.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    47. The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury. Liver Transpl. 2008 Aug; 14(8):1133-41. Fondevila C, Shen XD, Tsuchihashi S, Uchida Y, Freitas MC, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 18668646; PMCID: PMC2975482.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    48. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl. 2007 Oct; 13(10):1435-43. Shen XD, Ke B, Zhai Y, Gao F, Tsuchihashi S, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. PMID: 17902130.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    49. Diannexin, a novel annexin V homodimer, protects rat liver transplants against cold ischemia-reperfusion injury. Am J Transplant. 2007 Nov; 7(11):2463-71. Shen XD, Ke B, Zhai Y, Tsuchihashi SI, Gao F, Duarte S, Coito A, Busuttil RW, Allison AC, Kupiec-Weglinski JW. PMID: 17868064.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    50. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther. 2007 Apr; 18(4):355-66. Ke B, Shen XD, Tsuchihashi S, Gao F, Araujo JA, Busuttil RW, Ritter T, Kupiec-Weglinski JW. PMID: 17439357.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    51. Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury. Am J Pathol. 2006 Feb; 168(2):695-705. Tsuchihashi S, Ke B, Kaldas F, Flynn E, Busuttil RW, Briscoe DM, Kupiec-Weglinski JW. PMID: 16436682; PMCID: PMC1780159.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    52. Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation. J Immunol. 2006 Jan 01; 176(1):616-24. Tsuchihashi S, Fondevila C, Shaw GD, Lorenz M, Marquette K, Benard S, Shen XD, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 16365457.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    53. Gene therapy in liver ischemia and reperfusion injury. Curr Pharm Des. 2006; 12(23):2969-75. Ke B, Lipshutz GS, Kupiec-Weglinski JW. PMID: 16918425.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    54. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl. 2005 Oct; 11(10):1273-81. Shen XD, Gao F, Ke B, Zhai Y, Lassman CR, Tsuchihashi S, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. PMID: 16184555.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    55. Disruption of P-selectin signaling modulates cell trafficking and results in improved outcomes after mouse warm intestinal ischemia and reperfusion injury. Transplantation. 2005 Sep 27; 80(6):828-35. Farmer DG, Anselmo D, Da Shen X, Ke B, Carmody IC, Gao F, Lassman C, McDiarmid SV, Shaw G, Busuttil RW, Kupiec-Weglinski JW. PMID: 16210972.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    56. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant. 2005 Aug; 5(8):1793-800. Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15996225.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    57. The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses. Transplantation. 2005 May 15; 79(9):1078-83. Ke B, Shen XD, Gao F, Tsuchihashi S, Farmer DG, Briscoe D, Busuttil RW, Kupiec-Weglinski JW. PMID: 15880047; PMCID: PMC4470618.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    58. CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation. Transplantation. 2005 Jan 15; 79(1):44-51. Farmer DG, Shen XD, Amersi F, Anselmo D, Ma JP, Ke B, Gao F, Dry S, Fernandez S, Shaw GD, McDiarmid SV, Busuttil RW, Kupiec-Weglinski J. PMID: 15714168.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    59. Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection. Hum Gene Ther. 2004 Jul; 15(7):691-8. Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 15242529.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    60. P-selectin knockout mice have improved outcomes with both warm ischemia and small bowel transplantation. Transplant Proc. 2004 Mar; 36(2):263-4. Carmody IC, Meng L, Shen XD, Anselmo D, Gao F, Ke B, Ma JP, Kupiec-Weglinski JW, McDiarmid SV, Busuttil RW, Shaw G, Farmer DG. PMID: 15050128.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    61. Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. Mol Ther. 2004 Jan; 9(1):38-45. Ke B, Shen XD, Gao F, Busuttil RW, Löwenstein PR, Castro MG, Kupiec-Weglinski JW. PMID: 14741776; PMCID: PMC2913595.
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    62. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Am J Transplant. 2003 Sep; 3(9):1076-82. Ke B, Shen XD, Lassman CR, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 12919086.
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    63. Interleukin-13 gene transfer protects rat livers from antigen-independent injury induced by ischemia and reperfusion. Transplantation. 2003 Apr 27; 75(8):1118-23. Ke B, Shen XD, Lassman CR, Gao F, Katori M, Busuttil RW, Kupiec-Weglinski JW. PMID: 12717188.
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    64. Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J Am Soc Nephrol. 2003 Mar; 14(3):745-54. Blydt-Hansen TD, Katori M, Lassman C, Ke B, Coito AJ, Iyer S, Buelow R, Ettenger R, Busuttil RW, Kupiec-Weglinski JW. PMID: 12595512.
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    65. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology. 2003 Feb; 37(2):296-303. Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. PMID: 12540779.
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    66. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002 Oct 10; 13(15):1845-57. Ke B, Shen XD, Zhai Y, Gao F, Busuttil RW, Volk HD, Kupiec-Weglinski JW. PMID: 12396617.
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    67. FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. Am J Transplant. 2002 Oct; 2(9):843-9. Anselmo DM, Amersi FF, Shen XD, Gao F, Katori M, Lassman C, Ke B, Coito AJ, Ma J, Brinkmann V, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 12392290.
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    68. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation. 2002 Aug 15; 74(3):315-9. Shen XD, Ke B, Zhai Y, Amersi F, Gao F, Anselmo DM, Busuttil RW, Kupiec-Weglinski JW. PMID: 12177608.
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    69. Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury. Hum Gene Ther. 2002 Aug 10; 13(12):1495-504. Sawitzki B, Amersi F, Ritter T, Fisser M, Shen XD, Ke B, Busuttil R, Volk HD, Kupiec-Weglinski JW. PMID: 12215270.
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    70. FTY720: a novel approach to the treatment of hepatic ischemia-reperfusion injury. Transplant Proc. 2002 Aug; 34(5):1467-8. Anselmo D, Amersi FF, Shen XD, Gao F, Katori M, Ke B, Lassman C, Coito AJ, Brinkmann V, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 12176443.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    71. Heme oxygenase-1 gene transfer prevents CD95/FasL-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway. Transplant Proc. 2002 Aug; 34(5):1465-6. Ke B, Shen XD, Buelow R, Melinek J, Amersi F, Gao F, Ritter T, Volk HD, Busuttil RW, Kupiec-Weglinski JW. PMID: 12176442.
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    72. Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway. Hum Gene Ther. 2002 Jul 01; 13(10):1189-99. Ke B, Buelow R, Shen XD, Melinek J, Amersi F, Gao F, Ritter T, Volk HD, Busuttil RW, Kupiec-Weglinski JW. PMID: 12133272.
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    73. Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation. 2002 Jan 27; 73(2):287-92. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, Southard D, Busuttil RW, Kupiec-Weglinski JW. PMID: 11821745.
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    74. Selectin-mediated interactions regulate cytokine networks and macrophage heme oxygenase-1 induction in cardiac allograft recipients. Lab Invest. 2002 Jan; 82(1):61-70. Coito AJ, Shaw GD, Li J, Ke B, Ma J, Busuttil RW, Kupiec-Weglinski JW. PMID: 11796826.
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    75. Heme oxygenase-1 overexpression protects rat livers from ischemia/reperfusion injury with extended cold preservation. Am J Transplant. 2001 Jul; 1(2):121-8. Kato H, Amersi F, Buelow R, Melinek J, Coito AJ, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 12099359.
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    76. Heme oxygenase-1 gene therapy: a novel immunomodulatory approach in liver allograft recipients? Transplant Proc. 2001 Feb-Mar; 33(1-2):581-2. Ke B, Shen XD, Melinek J, Gao F, Ritter T, Volk HD, Busuttil RW, Kupiec-Weglinski JW. PMID: 11266967.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    77. Antisense TGF-beta2 immunotherapy for hepatocellular carcinoma: treatment in a rat tumor model. Ann Surg Oncol. 2001 Jan-Feb; 8(1):32-7. Maggard M, Meng L, Ke B, Allen R, Devgan L, Imagawa DK. PMID: 11206222.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    78. Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients. J Immunol. 2000 Jun 01; 164(11):5739-45. Ke B, Ritter T, Kato H, Zhai Y, Li J, Lehmann M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. PMID: 10820251.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    79. Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression. Transplantation. 2000 Apr 27; 69(8):1690-4. Ke B, Coito AJ, Kato H, Zhai Y, Wang T, Sawitzki B, Seu P, Busuttil RW, Kupiec-Weglinski JW. PMID: 10836382.
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    80. Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway. Transplant Proc. 2000 Mar; 32(2):245-6. Kato H, Ritter T, Ke B, Murakami M, Kusano M, Busuttil RW, Kupiec-Weglinski JW. PMID: 10715405.
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    81. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Invest. 1999 Dec; 104(11):1631-9. Amersi F, Buelow R, Kato H, Ke B, Coito AJ, Shen XD, Zhao D, Zaky J, Melinek J, Lassman CR, Kolls JK, Alam J, Ritter T, Volk HD, Farmer DG, Ghobrial RM, Busuttil RW, Kupiec-Weglinski JW. PMID: 10587527; PMCID: PMC409865.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    82. Irradiation-induced up-regulation of Fas in esophageal squamous cell carcinoma is not accompanied by Fas ligand-mediated apoptosis. J Surg Oncol. 1999 Jun; 71(2):91-6. Rigberg DA, Centeno J, Kim FS, Ke B, Swenson K, Maggard M, McFadden DW. PMID: 10389864.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    83. Fas ligand gene transfer to renal allografts in rats: effects on allograft survival. Transplantation. 1998 Jan 27; 65(2):155-60. Swenson KM, Ke B, Wang T, Markowitz JS, Maggard MA, Spear GS, Imagawa DK, Goss JA, Busuttil RW, Seu P. PMID: 9458007.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    84. Effects of pravastatin on chronic rejection of rat cardiac allografts. Transplantation. 1998 Jan 27; 65(2):149-55. Maggard MA, Ke B, Wang T, Kaldas F, Seu P, Busuttil RW, Imagawa DK. PMID: 9458006.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    85. Pravastatin increases survival and inhibits natural killer cell enhancement factor in liver transplanted rats. J Surg Res. 1997 May; 69(2):393-8. Kakkis JL, Ke B, Dawson S, Maggard M, Si M, Kaldas F, Cai W, Shau H, Seu P, Sauri H, Busuttil RW, Imagawa DK. PMID: 9224413.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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