Brian J Skaggs

Title(s)Associate Adjunct Professor, Medicine
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    The Role of Monocytes in SLE-related Accelerated Atherosclerosis
    NIH K01AR059095Aug 1, 2010 - Jul 31, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cardiovascular disease in systemic lupus erythematosus. Rheumatol Immunol Res. 2021 Sep 01; 2(3):157-172. McMahon M, Seto R, Skaggs BJ. PMID: 35880242; PMCID: PMC9242526.
      View in: PubMed   Mentions: 1  
    2. A Panel of Biomarkers Associates With Increased Risk for Cardiovascular Events in Women With Systemic Lupus Erythematosus. ACR Open Rheumatol. 2021 Apr; 3(4):209-220. Skaggs BJ, Grossman J, Sahakian L, Perry L, FitzGerald J, Charles-Schoeman C, Gorn A, Taylor M, Moriarty J, Ragavendra N, Weisman M, Wallace DJ, Hahn BH, McMahon M. PMID: 33605563; PMCID: PMC8063147.
      View in: PubMed   Mentions: 12  
    3. Comparison of PREDICTS atherosclerosis biomarker changes after initiation of new treatments in patients with SLE. Lupus Sci Med. 2019; 6(1):e000321. McMahon M, Skaggs B, Grossman J, Wong WK, Sahakian L, Chen W, Hahn B. PMID: 31321062; PMCID: PMC6606066.
      View in: PubMed   Mentions: 3     Fields:    
    4. Autoimmunity: Do IgM antibodies protect against atherosclerosis in SLE? Nat Rev Rheumatol. 2016 08; 12(8):442-4. McMahon M, Skaggs B. PMID: 27357254; PMCID: PMC6152880.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    5. MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14876-81. Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. PMID: 25271328; PMCID: PMC4205655.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    6. Pathogenesis and treatment of atherosclerosis in lupus. Rheum Dis Clin North Am. 2014 Aug; 40(3):475-95, viii. McMahon M, Skaggs B. PMID: 25034157; PMCID: PMC6152881.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    7. Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells. Arthritis Rheumatol. 2014 Mar; 66(3):674-85. Lourenço EV, Wong M, Hahn BH, Palma-Diaz MF, Skaggs BJ. PMID: 24574228.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    8. A panel of biomarkers is associated with increased risk of the presence and progression of atherosclerosis in women with systemic lupus erythematosus. Arthritis Rheumatol. 2014 Jan; 66(1):130-9. McMahon M, Skaggs BJ, Grossman JM, Sahakian L, Fitzgerald J, Wong WK, Lourenco EV, Ragavendra N, Charles-Schoeman C, Gorn A, Karpouzas GA, Taylor MB, Watson KE, Weisman MH, Wallace DJ, Hahn BH. PMID: 24449580; PMCID: PMC4106468.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    9. Accelerated atherosclerosis in patients with SLE--mechanisms and management. Nat Rev Rheumatol. 2012 Feb 14; 8(4):214-23. Skaggs BJ, Hahn BH, McMahon M. PMID: 22331061; PMCID: PMC3765069.
      View in: PubMed   Mentions: 89     Fields:    Translation:Humans
    10. Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia. PLoS One. 2011; 6(11):e27682. Leder K, Foo J, Skaggs B, Gorre M, Sawyers CL, Michor F. PMID: 22140458; PMCID: PMC3225363.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    11. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis. 2011 Sep; 70(9):1619-24. McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum JL, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH. PMID: 21670088; PMCID: PMC3147230.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    12. Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice. Lupus. 2011 Aug; 20(9):912-20. Skaggs BJ, Lourenço EV, Hahn BH. PMID: 21562020.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    13. Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Sci Signal. 2011 Mar 29; 4(166):ra18. Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, Low T, Tahmasian M, Skaggs B, Müschen M, Pellegrini M, Graeber TG. PMID: 21447799; PMCID: PMC4057100.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    14. Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention. Expert Rev Clin Immunol. 2011 Mar; 7(2):227-41. McMahon M, Hahn BH, Skaggs BJ. PMID: 21426260; PMCID: PMC3718673.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    15. Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production. Clin Immunol. 2010 Oct; 137(1):147-56. Skaggs BJ, Hahn BH, Sahakian L, Grossman J, McMahon M. PMID: 20637704; PMCID: PMC2941543.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    16. Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin. Lupus. 2010 Jul; 19(8):913-7. Hahn BH, Lourencço EV, McMahon M, Skaggs B, Le E, Anderson M, Iikuni N, Lai CK, La Cava A. PMID: 20410156; PMCID: PMC3159424.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    17. CD8+ Tregs in lupus, autoimmunity, and beyond. Autoimmun Rev. 2010 Jun; 9(8):560-8. Dinesh RK, Skaggs BJ, La Cava A, Hahn BH, Singh RP. PMID: 20385256; PMCID: PMC2879466.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    18. Maximal entropy inference of oncogenicity from phosphorylation signaling. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):6112-7. Graeber TG, Heath JR, Skaggs BJ, Phelps ME, Remacle F, Levine RD. PMID: 20224037; PMCID: PMC2851899.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2010 Feb; 62(2):258-65. Volkmann ER, Grossman JM, Sahakian LJ, Skaggs BJ, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chen W, Gorn A, Karpouzas G, Weisman M, Wallace DJ, Hahn BH, McMahon M. PMID: 20191526; PMCID: PMC2853476.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    20. Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus. Arthritis Rheum. 2009 Aug; 60(8):2428-37. McMahon M, Grossman J, Skaggs B, Fitzgerald J, Sahakian L, Ragavendra N, Charles-Schoeman C, Watson K, Wong WK, Volkmann E, Chen W, Gorn A, Karpouzas G, Weisman M, Wallace DJ, Hahn BH. PMID: 19644959; PMCID: PMC2753974.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    21. Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice. Hum Immunol. 2008 Nov; 69(11):790-6. Skaggs BJ, Singh RP, Hahn BH. PMID: 18817829; PMCID: PMC2621070.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Res Ther. 2008; 10(4):213. Hahn BH, Grossman J, Ansell BJ, Skaggs BJ, McMahon M. PMID: 18828865; PMCID: PMC2575639.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    23. IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells. Mol Cancer Ther. 2008 Feb; 7(2):391-7. Duncan EA, Goetz CA, Stein SJ, Mayo KJ, Skaggs BJ, Ziegelbauer K, Sawyers CL, Baldwin AS. PMID: 18245668.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J Clin Invest. 2007 Sep; 117(9):2562-9. Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL. PMID: 17710227; PMCID: PMC1940237.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    25. Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19466-71. Skaggs BJ, Gorre ME, Ryvkin A, Burgess MR, Xie Y, Han Y, Komisopoulou E, Brown LM, Loo JA, Landaw EM, Sawyers CL, Graeber TG. PMID: 17164333; PMCID: PMC1698443.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    26. Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc Natl Acad Sci U S A. 2005 Mar 01; 102(9):3395-400. Burgess MR, Skaggs BJ, Shah NP, Lee FY, Sawyers CL. PMID: 15705718; PMCID: PMC552942.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    27. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol. 2002 Apr; 22(8):2524-35. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR. PMID: 11909947; PMCID: PMC133735.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    28. Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. J Immunol. 2002 Mar 01; 168(5):2127-38. Siemasko K, Skaggs BJ, Kabak S, Williamson E, Brown BK, Song W, Clark MR. PMID: 11859098.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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