Carolyn R Houser

Title(s)Professor, Neurobiology
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    Role of Neuronal Loss in Epileptogenesis
    NIH R01NS102608Jun 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Epilepsy related cell loss and cognitive dysfunction
    NIH R01NS099137Jun 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    2012 Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conferen
    NIH R13NS078797May 1, 2012 - Apr 30, 2013
    Role: Principal Investigator
    GABA System Alterations and Fragile X Syndrome
    NIH R01HD067225Feb 20, 2012 - Jan 31, 2018
    Role: Principal Investigator
    GABA Receptor Plasticity and Tonic Inhibition in Epilepsy
    NIH R01NS075245Feb 1, 2012 - Jan 31, 2021
    Role: Principal Investigator
    Neuronal Loss and Plasticity in Epilepsy
    NIH I01BX000404Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    GABA Receptor Subunit Plasticity in Epilepsy
    NIH R56NS051311Apr 1, 2005 - Jul 31, 2012
    Role: Principal Investigator
    GABA Receptor Subunit Plasticity in Epilepsy
    NIH R01NS051311Apr 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    GABA Neurons and Epilepsy
    NIH R01NS046524Jul 1, 2003 - Jun 30, 2010
    Role: Principal Investigator
    NIH R01NS033360Dec 1, 1995 - Nov 30, 2001
    Role: Principal Investigator
    NIH R01NS029231Mar 1, 1991 - Feb 28, 1995
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A therapeutic small molecule lead enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice. bioRxiv. 2023 Dec 06. Wei X, Campagna JJ, Jagodzinska B, Wi D, Cohn W, Lee J, Zhu C, Huang CS, Molnár L, Houser CR, John V, Mody I. PMID: 38106006; PMCID: PMC10723366.
      View in: PubMed   Mentions:
    2. Virally-induced expression of GABAA receptor δ subunits following their pathological loss reveals their role in regulating GABAA receptor assembly. Prog Neurobiol. 2022 11; 218:102337. Sun Y, Peng Z, Wei X, Zhang N, Huang CS, Wallner M, Mody I, Houser CR. PMID: 35934131; PMCID: PMC10091858.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    3. Mossy Cells in the Dorsal and Ventral Dentate Gyrus Differ in Their Patterns of Axonal Projections. J Neurosci. 2021 02 03; 41(5):991-1004. Houser CR, Peng Z, Wei X, Huang CS, Mody I. PMID: 33268544; PMCID: PMC7880284.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    4. Decreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome. Exp Neurol. 2017 11; 297:168-178. Zhang N, Peng Z, Tong X, Lindemeyer AK, Cetina Y, Huang CS, Olsen RW, Otis TS, Houser CR. PMID: 28822839; PMCID: PMC5612918.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    5. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. J Neurosci. 2015 Dec 09; 35(49):16142-58. Tong X, Peng Z, Zhang N, Cetina Y, Huang CS, Wallner M, Otis TS, Houser CR. PMID: 26658866; PMCID: PMC4682781.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    6. Do structural changes in GABA neurons give rise to the epileptic state? Adv Exp Med Biol. 2014; 813:151-60. Houser CR. PMID: 25012374; PMCID: PMC4634888.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    7. Altered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout mice. Neurochem Res. 2014 Jun; 39(6):1104-17. Peng Z, Zhang N, Chandra D, Homanics GE, Olsen RW, Houser CR. PMID: 24352815; PMCID: PMC4024081.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    8. Number and regional distribution of GAD65 mRNA-expressing interneurons in the rat hippocampal formation. Acta Biol Hung. 2013 Dec; 64(4):395-413. Czéh B, Abrahám H, Tahtakran S, Houser CR, Seress L. PMID: 24275587.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons. J Neurosci. 2013 Sep 04; 33(36):14392-405. Peng Z, Zhang N, Wei W, Huang CS, Cetina Y, Otis TS, Houser CR. PMID: 24005292; PMCID: PMC3761049.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    10. Effects of climbing fiber driven inhibition on Purkinje neuron spiking. J Neurosci. 2012 Dec 12; 32(50):17988-97. Mathews PJ, Lee KH, Peng Z, Houser CR, Otis TS. PMID: 23238715; PMCID: PMC3532857.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    11. Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells. Epilepsia. 2012 Jun; 53 Suppl 1:67-77. Houser CR, Zhang N, Peng Z, Huang CS, Cetina Y. PMID: 22612811; PMCID: PMC4214139.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences. Eur J Neurosci. 2010 Sep; 32(5):771-85. Soussi R, Zhang N, Tahtakran S, Houser CR, Esclapez M. PMID: 20722723; PMCID: PMC2974797.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    13. Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci. 2010 Jun 30; 30(26):8993-9006. Wyeth MS, Zhang N, Mody I, Houser CR. PMID: 20592220; PMCID: PMC3319326.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    14. Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy. Exp Neurol. 2010 Jul; 224(1):133-45. Li Y, Peng Z, Xiao B, Houser CR. PMID: 20226181; PMCID: PMC2893891.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    15. The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. Front Behav Neurosci. 2009; 3:37. Wiltgen BJ, Godsil BP, Peng Z, Saab F, June HL, Linn ML, Cook JM, Houser CR, O'Dell TJ, Homanics GE, Fanselow MS. PMID: 19876409; PMCID: PMC2769557.
      View in: PubMed   Mentions: 24  
    16. Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy. Neuroscience. 2008 Sep 22; 156(1):222-37. Houser CR, Huang CS, Peng Z. PMID: 18675888; PMCID: PMC2651028.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    17. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis. 2008 Jul; 46(7):357-67. Heusner CL, Beutler LR, Houser CR, Palmiter RD. PMID: 18615733; PMCID: PMC3360952.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    18. Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci. 2007 Jul 11; 27(28):7520-31. Zhang N, Wei W, Mody I, Houser CR. PMID: 17626213; PMCID: PMC6672608.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    19. Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity. Prog Brain Res. 2007; 163:217-32. Houser CR. PMID: 17765721.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    20. A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. Nat Neurosci. 2007 Jan; 10(1):40-8. Glykys J, Peng Z, Chandra D, Homanics GE, Houser CR, Mody I. PMID: 17159992.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    21. Hippocampal cell loss in posttraumatic human epilepsy. Epilepsia. 2006 Aug; 47(8):1373-82. Swartz BE, Houser CR, Tomiyasu U, Walsh GO, DeSalles A, Rich JR, Delgado-Escueta A. PMID: 16922884.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    22. Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. J Neurosci. 2006 Feb 08; 26(6):1749-58. Liang J, Zhang N, Cagetti E, Houser CR, Olsen RW, Spigelman I. PMID: 16467523; PMCID: PMC6793625.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    23. Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice. J Comp Neurol. 2005 Dec 26; 493(4):524-37. Farrar CE, Huang CS, Clarke SG, Houser CR. PMID: 16304629.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy. J Neurosci. 2005 Aug 03; 25(31):7210-20. Peng Z, Houser CR. PMID: 16079403; PMCID: PMC6725230.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    25. Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice. Aging Cell. 2005 Feb; 4(1):1-12. Farrar C, Houser CR, Clarke S. PMID: 15659208.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. J Neurosci. 2004 Sep 29; 24(39):8629-39. Peng Z, Huang CS, Stell BM, Mody I, Houser CR. PMID: 15456836; PMCID: PMC6729896.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    27. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J Neurosci. 2003 Nov 19; 23(33):10650-61. Wei W, Zhang N, Peng Z, Houser CR, Mody I. PMID: 14627650; PMCID: PMC6740905.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    28. Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy. Hippocampus. 2003; 13(5):633-45. Houser CR, Esclapez M. PMID: 12921352.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    29. GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. J Comp Neurol. 2002 Apr 29; 446(2):179-97. Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR. PMID: 11932935.
      View in: PubMed   Mentions: 119     Fields:    Translation:Animals
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