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Cohesin complex mutations in myeloid neoplasms are enriched for SRSF2, RUNX1, TET2, and NRAS co-mutations and morphologic dysplasia. Leuk Res. 2023 Sep; 132:107357.
Hirt CK, Padmanabha N, Michaels PD. PMID: 37481994.
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PubMed Mentions: Fields:
Translation:
Humans
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Myeloid sarcoma with NPM1 mutation may be clinically and genetically distinct from AML with NPM1 mutation: a study from the Bone Marrow Pathology Group. Leuk Lymphoma. 2023 May; 64(5):972-980.
Ramia de Cap M, Wu LP, Hirt C, Pihan GA, Patel SS, Tam W, Bueso-Ramos CE, Kanagal-Shamanna R, Raess PW, Siddon A, Narayanan D, Morgan EA, Pinkus GS, Mason EF, Hsi ED, Rogers HJ, Toth L, Foucar K, Hurwitz SN, Bagg A, Rets A, George TI, Orazi A, Arber DA, Hasserjian RP, Weinberg OK, Bone Marrow Pathology Group. PMID: 36960680.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Tumor Organoids as a Research Tool: How to Exploit Them. Cells. 2022 Oct 31; 11(21).
Booij TH, Cattaneo CM, Hirt CK. PMID: 36359838; PMCID: PMC9653788.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer. Cell Rep. 2022 Aug 23; 40(8):111266.
Simmler P, Cortijo C, Koch LM, Galliker P, Angori S, Bolck HA, Mueller C, Vukolic A, Mirtschink P, Christinat Y, Davidson NR, Lehmann KV, Pellegrini G, Pauli C, Lenggenhager D, Guccini I, Ringel T, Hirt C, Marquart KF, Schaefer M, Rätsch G, Peter M, Moch H, Stoffel M, Schwank G. PMID: 36001976.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment. Diagnostics (Basel). 2022 Apr 27; 12(5).
Ta R, Yang D, Hirt C, Drago T, Flavin R. PMID: 35626243; PMCID: PMC9139291.
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PubMed Mentions:
4
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Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment. Cell Genom. 2022 Feb; 2(2):100095.
Hirt CK, Booij TH, Grob L, Simmler P, Toussaint NC, Keller D, Taube D, Ludwig V, Goryachkin A, Pauli C, Lenggenhager D, Stekhoven DJ, Stirnimann CU, Endhardt K, Ringnalda F, Villiger L, Siebenhüner A, Karkampouna S, De Menna M, Beshay J, Klett H, Kruithof-de Julio M, Schüler J, Schwank G. PMID: 35187519; PMCID: PMC7612395.
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PubMed Mentions:
41 Fields:
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miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis. Gastroenterology. 2022 Jan; 162(1):269-284.
Ge W, Goga A, He Y, Silva PN, Hirt CK, Herrmanns K, Guccini I, Godbersen S, Schwank G, Stoffel M. PMID: 34547282.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3. Genomics. 2021 Mar; 113(2):515-529.
Markolin P, Davidson N, Hirt CK, Chabbert CD, Zamboni N, Schwank G, Krek W, Rätsch G. PMID: 33418078.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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First-line treatment with R-CHOP or rituximab-bendamustine in patients with follicular lymphoma grade 3A-results of a retrospective analysis. Ann Hematol. 2020 Dec; 99(12):2821-2829.
Pouyiourou M, Meyer A, Stroux A, Viardot A, La Rosée P, Maschmeyer G, Kämpfe D, Kahl C, Vucinic V, Monecke A, Hirt C, Weber T, Meissner J, Witzens-Harig M, Böttcher S, Schmalenberg H, Marks R, Prange-Krex G, Kroschinsky F, Hauf E, Keller U, Koch K, Klapper W, Herold M, Scholz CW, East German Study Group for Hematology and Oncology (OSHO). PMID: 32734548.
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Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor-Based 3D Culture System. Adv Biosyst. 2019 Apr; 3(4):e1800300.
Manfredonia C, Muraro MG, Hirt C, Mele V, Governa V, Papadimitropoulos A, Däster S, Soysal SD, Droeser RA, Mechera R, Oertli D, Rosso R, Bolli M, Zettl A, Terracciano LM, Spagnoli GC, Martin I, Iezzi G. PMID: 32627426.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat Med. 2019 Jan; 25(1):89-94.
Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN. PMID: 30510250.
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PubMed Mentions:
332 Fields:
Translation:
HumansCells
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Growth of Epithelial Organoids in a Defined Hydrogel. Adv Mater. 2018 Oct; 30(43):e1801621.
Broguiere N, Isenmann L, Hirt C, Ringel T, Placzek S, Cavalli E, Ringnalda F, Villiger L, Züllig R, Lehmann R, Rogler G, Heim MH, Schüler J, Zenobi-Wong M, Schwank G. PMID: 30203567.
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PubMed Mentions:
138 Fields:
Translation:
HumansAnimalsCells
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rBPI21 (Opebacan) Promotes Rapid Trilineage Hematopoietic Recovery in a Murine Model of High-Dose Total Body Irradiation. Am J Hematol. 2018 May 11.
Janec KJ, Yuan H, Norton JE, Kelner RH, Hirt CK, Betensky RA, Guinan EC. PMID: 29752735; PMCID: PMC6230507.
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PubMed Mentions:
3 Fields:
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High-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study). Leukemia. 2017 04; 31(4):846-852.
Fritsch K, Kasenda B, Schorb E, Hau P, Bloehdorn J, Möhle R, Löw S, Binder M, Atta J, Keller U, Wolf HH, Krause SW, Heß G, Naumann R, Sasse S, Hirt C, Lamprecht M, Martens U, Morgner A, Panse J, Frickhofen N, Röth A, Hader C, Deckert M, Fricker H, Ihorst G, Finke J, Illerhaus G. PMID: 27843136; PMCID: PMC5383936.
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PubMed Mentions:
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Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. Gut. 2017 04; 66(4):692-704.
Amicarella F, Muraro MG, Hirt C, Cremonesi E, Padovan E, Mele V, Governa V, Han J, Huber X, Droeser RA, Zuber M, Adamina M, Bolli M, Rosso R, Lugli A, Zlobec I, Terracciano L, Tornillo L, Zajac P, Eppenberger-Castori S, Trapani F, Oertli D, Iezzi G. PMID: 26719303; PMCID: PMC5529969.
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PubMed Mentions:
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Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis. Oncoimmunology. 2015 Dec; 4(12):e1050574.
Däster S, Eppenberger-Castori S, Hirt C, Soysal SD, Delko T, Nebiker CA, Weixler B, Amicarella F, Iezzi G, Governa V, Padovan E, Mele V, Sconocchia G, Heberer M, Terracciano L, Kettelhack C, Oertli D, Spagnoli GC, von Holzen U, Tornillo L, Droeser RA. PMID: 26587320; PMCID: PMC4635694.
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PubMed Mentions:
16 Fields:
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Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo". Biomaterials. 2015 Sep; 62:138-46.
Hirt C, Papadimitropoulos A, Muraro MG, Mele V, Panopoulos E, Cremonesi E, Ivanek R, Schultz-Thater E, Droeser RA, Mengus C, Heberer M, Oertli D, Iezzi G, Zajac P, Eppenberger-Castori S, Tornillo L, Terracciano L, Martin I, Spagnoli GC. PMID: 26051518.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Impact of prior treatment on outcome of transformed follicular lymphoma and relapsed de novo diffuse large B cell lymphoma: a retrospective multicentre analysis. Ann Hematol. 2015 Jun; 94(6):981-8.
Lerch K, Meyer AH, Stroux A, Hirt C, Keller U, Viardot A, Marks R, Schreiber S, Pezzutto A, Scholz CW. PMID: 25645656.
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PubMed Mentions:
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High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer. Dis Markers. 2014; 2014:792183.
Däster S, Eppenberger-Castori S, Hirt C, Zlobec I, Delko T, Nebiker CA, Soysal SD, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Spagnoli GC, Kettelhack C, Terracciano L, Oertli D, von Holzen U, Tornillo L, Droeser RA. PMID: 25609852; PMCID: PMC4293805.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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"In vitro" 3D models of tumor-immune system interaction. Adv Drug Deliv Rev. 2014 Dec 15; 79-80:145-54.
Hirt C, Papadimitropoulos A, Mele V, Muraro MG, Mengus C, Iezzi G, Terracciano L, Martin I, Spagnoli GC. PMID: 24819215.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimals
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GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer. Clin Cancer Res. 2014 Jun 15; 20(12):3094-106.
Nebiker CA, Han J, Eppenberger-Castori S, Iezzi G, Hirt C, Amicarella F, Cremonesi E, Huber X, Padovan E, Angrisani B, Droeser RA, Rosso R, Bolli M, Oertli D, von Holzen U, Adamina M, Muraro MG, Mengus C, Zajac P, Sconocchia G, Zuber M, Tornillo L, Terracciano L, Spagnoli GC. PMID: 24737547.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis. Oncoimmunology. 2013 Oct 01; 2(10):e25990.
Hirt C, Eppenberger-Castori S, Sconocchia G, Iezzi G, Tornillo L, Terracciano L, Spagnoli GC, Droeser RA. PMID: 24244897; PMCID: PMC3825723.
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PubMed Mentions:
12 Fields:
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High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor. PLoS One. 2013; 8(5):e64814.
Droeser RA, Hirt C, Eppenberger-Castori S, Zlobec I, Viehl CT, Frey DM, Nebiker CA, Rosso R, Zuber M, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Tornillo L, Oertli D, Terracciano L, Spagnoli GC. PMID: 23734221; PMCID: PMC3667167.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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High IL-17-positive tumor immune cell infiltration is indicative for chemosensitivity of ovarian carcinoma. J Cancer Res Clin Oncol. 2013 Aug; 139(8):1295-302.
Droeser RA, Güth U, Eppenberger-Castori S, Stadlmann S, Hirt C, Terracciano L, Singer G. PMID: 23624523; PMCID: PMC11824547.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer. 2013 Jun; 49(9):2233-42.
Droeser RA, Hirt C, Viehl CT, Frey DM, Nebiker C, Huber X, Zlobec I, Eppenberger-Castori S, Tzankov A, Rosso R, Zuber M, Muraro MG, Amicarella F, Cremonesi E, Heberer M, Iezzi G, Lugli A, Terracciano L, Sconocchia G, Oertli D, Spagnoli GC, Tornillo L. PMID: 23478000.
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PubMed Mentions:
241 Fields:
Translation:
HumansCells