Christopher J Evans

Title(s)Professor-in-Residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
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    Christopher J. Evans, Ph.D., holds the Stefan Hatos Endowed Chair in Psychiatry and Biobehavioral Sciences.

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    Translational Methods/Facilities Core (TMF - Core) (8 of 8)
    NIH PL1NS062410Sep 30, 2007 - Jun 30, 2013
    Role: Principal Investigator
    MUTATIONAL LIBRARIES TO STUDY OPIOID RECEPTOR FUNCTION
    NIH R03DA011962Jul 1, 1998 - May 31, 2001
    Role: Principal Investigator
    Center for Study of Opioid Receptors and Drugs of Abuse (CSORDA)
    NIH P50DA005010Jun 30, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An Orally Administered Misuse Deterrent Opioid Prodrug for Treatment of Acute Pain. JACS Au. 2025 Oct 27; 5(10):5199-5206. Rose DA, Treacy JW, Seth K, Tanzillo AF, Li A, Tamshen K, Sloan LK, Boehnke N, Evans CJ, Cahill CM, Maynard HD. PMID: 41169550; PMCID: PMC12569658.
      View in: PubMed   Mentions:
    2. Opposing effects of mu opioid receptors on dopamine D1 and D2 receptor expressing neurons in opioid mediated antinociception. J Pain. 2025 Oct; 35:105474. Alderete J, Tanzillo A, Miller J, Barrall L, Nasef H, Ellis E, Sigal G, Silva FD'D, Dagher M, Evans CJ, Cahill CM. PMID: 40578498.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Chronic pain selectively reduces the motivation to work for remifentanil but not food reward. Pain. 2025 05 13; 166(9):e212-e232. Lueptow L, Shashkova L, Twombly E, Greenhill H, Yang H, Taylor AMW, Cameron CM, Evans CJ, Andrews AM, Cahill CM. PMID: 40839625.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Opioid Systems and Depression: The Relationship Is Strengthening. Biol Psychiatry. 2022 12 15; 92(12):920-922. Dagher M, Cahill CM, Evans CJ. PMID: 36396245.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Dissociable effects of oxycodone on behavior, calcium transient activity, and excitability of dorsolateral striatal neurons. Front Neural Circuits. 2022; 16:983323. Barry J, Oikonomou KD, Peng A, Yu D, Yang C, Golshani P, Evans CJ, Levine MS, Cepeda C. PMID: 36389179; PMCID: PMC9643681.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. Addict Biol. 2022 07; 27(4):e13182. Grodin EN, Nieto SJ, Meredith LR, Burnette E, O'Neill J, Alger J, London ED, Miotto K, Evans CJ, Irwin MR, Ray LA. PMID: 35754106; PMCID: PMC9888600.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    7. Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction. Handb Exp Pharmacol. 2022; 271:315-350. Cahill CM, Lueptow L, Kim H, Shusharla R, Bishop A, Evans CJ. PMID: 33547588; PMCID: PMC9436635.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Oxycodone in the Opioid Epidemic: High 'Liking', 'Wanting', and Abuse Liability. Cell Mol Neurobiol. 2021 Jul; 41(5):899-926. Kibaly C, Alderete JA, Liu SH, Nasef HS, Law PY, Evans CJ, Cahill CM. PMID: 33245509; PMCID: PMC8155122.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsPHPublic Health
    9. An Undergraduate Student-Led Neuroscience Outreach Program Shows Promise in Shifting Teen Attitudes About Drugs. Mind Brain Educ. 2020 Nov; 14(4):387-399. Lichtenberg NT, Thompson AB, Iguchi MY, Evans CJ, Romero-Calderón R. PMID: 33381224; PMCID: PMC7756680.
      View in: PubMed   Mentions: 3  
    10. Insights into the Neurobiology of Craving in Opioid Use Disorder. Curr Anesthesiol Rep. 2020 Dec; 10(4):378-387. Lueptow LM, Shashkova EC, Miller MG, Evans CJ, Cahill CM. PMID: 33424457; PMCID: PMC7790122.
      View in: PubMed   Mentions: 7  
    11. μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors. eNeuro. 2020 Sep/Oct; 7(5). Severino AL, Mittal N, Hakimian JK, Velarde N, Minasyan A, Albert R, Torres C, Romaneschi N, Johnston C, Tiwari S, Lee AS, Taylor AM, Gavériaux-Ruff C, Kieffer BL, Evans CJ, Cahill CM, Walwyn WM. PMID: 32859725; PMCID: PMC7508564.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    12. Genetic and functional analysis of a Pacific hagfish opioid system. J Neurosci Res. 2022 01; 100(1):19-34. Huang AY, Taylor AMW, Ghogha A, Pribadi M, Wang Q, Kim TSJ, Cahill CM, Coppola G, Evans CJ. PMID: 32830380; PMCID: PMC11627053.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Sex differences in kappa opioid receptor antinociception is influenced by the number of X chromosomes in mouse. J Neurosci Res. 2022 01; 100(1):183-190. Taylor AMW, Chadwick CI, Mehrabani S, Hrncir H, Arnold AP, Evans CJ. PMID: 32731302; PMCID: PMC8452150.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma. Neuropsychopharmacology. 2020 02; 45(3):482-490. Pennington ZT, Trott JM, Rajbhandari AK, Li K, Walwyn WM, Evans CJ, Fanselow MS. PMID: 31787748; PMCID: PMC6968993.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    15. Digging through the roots of addiction: Understanding the causes that underlie the insidious problem of substance use disorders (SUDs). Neurosci Biobehav Rev. 2019 11; 106:3-4. Severino AL, Evans CJ. PMID: 31561848; PMCID: PMC7243729.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Quantitative assessments reveal improved neuroscience engagement and learning through outreach. J Neurosci Res. 2019 09; 97(9):1153-1162. Saravanapandian V, Sparck EM, Cheng KY, Yu F, Yaeger C, Hu T, Suthana N, Romero-Calderón R, Ghiani CA, Evans CJ, Carpenter EM, Ge W. PMID: 30985023.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain. J Neurosci. 2019 05 22; 39(21):4162-4178. Liu SS, Pickens S, Burma NE, Ibarra-Lecue I, Yang H, Xue L, Cook C, Hakimian JK, Severino AL, Lueptow L, Komarek K, Taylor AMW, Olmstead MC, Carroll FI, Bass CE, Andrews AM, Walwyn W, Trang T, Evans CJ, Leslie FM, Cahill CM. PMID: 30862664; PMCID: PMC6529867.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    18. Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect. Nat Rev Neurosci. 2019 01; 20(1):5-18. Kibaly C, Xu C, Cahill CM, Evans CJ, Law PY. PMID: 30518959; PMCID: PMC6736526.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    19. The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. Neuropsychopharmacology. 2018 12; 43(13):2606-2614. Lee K, Vuong HE, Nusbaum DJ, Hsiao EY, Evans CJ, Taylor AMW. PMID: 30258112; PMCID: PMC6224506.
      View in: PubMed   Mentions: 99     Fields:    Translation:Animals
    20. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron. 2018 09 19; 99(6):1170-1187.e9. Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. PMID: 30174118; PMCID: PMC6450394.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimalsCells
    21. Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation. Trends Pharmacol Sci. 2016 11; 37(11):963-976. Cahill CM, Walwyn W, Taylor AMW, Pradhan AAA, Evans CJ. PMID: 27670390; PMCID: PMC5240843.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    22. Neurobiology of opioid dependence in creating addiction vulnerability. F1000Res. 2016; 5. Evans CJ, Cahill CM. PMID: 27508068; PMCID: PMC4955026.
      View in: PubMed   Mentions: 65     Fields:    
    23. Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence. eNeuro. 2016 May-Jun; 3(3). Smith WC, Rosenberg MH, Claar LD, Chang V, Shah SN, Walwyn WM, Evans CJ, Masmanidis SC. PMID: 27390774; PMCID: PMC4917735.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function. J Neurosci. 2016 Mar 23; 36(12):3541-51. Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ. PMID: 27013682; PMCID: PMC4804011.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    25. Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine. Neuropsychopharmacology. 2016 Mar; 41(4):949-59. Taylor AM, Castonguay A, Ghogha A, Vayssiere P, Pradhan AA, Xue L, Mehrabani S, Wu J, Levitt P, Olmstead MC, De Koninck Y, Evans CJ, Cahill CM. PMID: 26202104; PMCID: PMC4748420.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    26. Microglia disrupt mesolimbic reward circuitry in chronic pain. J Neurosci. 2015 Jun 03; 35(22):8442-50. Taylor AM, Castonguay A, Taylor AJ, Murphy NP, Ghogha A, Cook C, Xue L, Olmstead MC, De Koninck Y, Evans CJ, Cahill CM. PMID: 26041913; PMCID: PMC4452552.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    27. Does the kappa opioid receptor system contribute to pain aversion? Front Pharmacol. 2014; 5:253. Cahill CM, Taylor AM, Cook C, Ong E, Morón JA, Evans CJ. PMID: 25452729; PMCID: PMC4233910.
      View in: PubMed   Mentions: 58  
    28. Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice. J Pain. 2014 Aug; 15(8):878-85. Taylor AM, Murphy NP, Evans CJ, Cahill CM. PMID: 25052072; PMCID: PMC4136541.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    29. Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nat Neurosci. 2014 Feb; 17(2):254-61. Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW. PMID: 24413699; PMCID: PMC4008330.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    30. Characterization of a novel model of chronic migraine. Pain. 2014 Feb; 155(2):269-274. Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A. PMID: 24121068; PMCID: PMC3920577.
      View in: PubMed   Mentions: 186     Fields:    Translation:Animals
    31. Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens. ASN Neuro. 2013 Oct 02; 5(4):257-71. Ma YY, Henley SM, Toll J, Jentsch JD, Evans CJ, Levine MS, Cepeda C. PMID: 24000958; PMCID: PMC3789142.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    32. Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons. Behav Brain Res. 2013 Nov 01; 256:279-83. James AS, Chen JY, Cepeda C, Mittal N, Jentsch JD, Levine MS, Evans CJ, Walwyn W. PMID: 23968589; PMCID: PMC3815993.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    33. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev. 2013 Jan; 65(1):223-54. Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. PMID: 23321159; PMCID: PMC3565916.
      View in: PubMed   Mentions: 456     Fields:    Translation:HumansAnimalsCells
    34. Ligand-directed signalling within the opioid receptor family. Br J Pharmacol. 2012 Nov; 167(5):960-9. Pradhan AA, Smith ML, Kieffer BL, Evans CJ. PMID: 22708627; PMCID: PMC3492979.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    35. Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons. ASN Neuro. 2012 Mar 08; 4(2). Ma YY, Cepeda C, Chatta P, Franklin L, Evans CJ, Levine MS. PMID: 22273000; PMCID: PMC3297119.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    36. Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice. Gastroenterology. 2011 Sep; 141(3):982-991.e18. Poole DP, Pelayo JC, Scherrer G, Evans CJ, Kieffer BL, Bunnett NW. PMID: 21699782; PMCID: PMC4429902.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    37. Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2. Mol Pain. 2011 Apr 12; 7:24. Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W. PMID: 21486473; PMCID: PMC3090352.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    38. Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions. Drug Alcohol Depend. 2010 May 01; 108(3):156-65. Walwyn WM, Miotto KA, Evans CJ. PMID: 20188495; PMCID: PMC3072810.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    39. Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons. Mol Pharmacol. 2009 Jul; 76(1):134-43. Walwyn W, John S, Maga M, Evans CJ, Hales TG. PMID: 19357247; PMCID: PMC2701458.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    40. p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons. J Biol Chem. 2009 Mar 06; 284(10):6270-81. Tan M, Walwyn WM, Evans CJ, Xie CW. PMID: 19126537; PMCID: PMC2649085.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    41. International Narcotics Research Conference - 39th Annual Meeting. IDrugs. 2008 Sep; 11(9):646-9. Wassum KM, Evans CJ. PMID: 18763214; PMCID: PMC4445826.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    42. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice. Horm Behav. 2008 Jan; 53(1):124-30. Gioiosa L, Chen X, Watkins R, Klanfer N, Bryant CD, Evans CJ, Arnold AP. PMID: 17956759; PMCID: PMC2713052.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    43. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. J Neurosci. 2007 May 09; 27(19):5092-104. Walwyn W, Evans CJ, Hales TG. PMID: 17494695; PMCID: PMC6672367.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    44. Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice. Pharmacol Biochem Behav. 2006 Dec; 85(4):769-79. Bryant CD, Roberts KW, Byun JS, Fanselow MS, Evans CJ. PMID: 17196637; PMCID: PMC1905890.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    45. NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R315-26. Bryant CD, Eitan S, Sinchak K, Fanselow MS, Evans CJ. PMID: 16601258.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    46. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Mol Pharmacol. 2005 Dec; 68(6):1688-98. Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG. PMID: 16135785.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    47. Secrets of the opium poppy revealed. Neuropharmacology. 2004; 47 Suppl 1:293-9. Evans CJ. PMID: 15464145.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    48. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. J Neurosci. 2003 Nov 12; 23(32):10331-7. Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. PMID: 14614092; PMCID: PMC6741014.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    49. Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization. J Neurosci. 2003 Sep 10; 23(23):8360-9. Eitan S, Bryant CD, Saliminejad N, Yang YC, Vojdani E, Keith D, Polakiewicz R, Evans CJ. PMID: 12967998; PMCID: PMC6740691.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    50. Morphine induces desensitization of insulin receptor signaling. Mol Cell Biol. 2003 Sep; 23(17):6255-66. Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD. PMID: 12917346; PMCID: PMC180943.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    51. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Mol Pharmacol. 2003 Jan; 63(1):89-95. Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, Hales TG. PMID: 12488540.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
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