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Claude G Wasterlain

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
Phone3102683595
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    Collapse Research 
    Collapse Research Activities and Funding
    Rational polytherapy in the treatment of cholinergic seizures
    NIH/NINDS U01NS074926Sep 15, 2011 - Aug 31, 2016
    Role: Principal Investigator
    Treatment of status epilepticus: a translational proposal.
    VA I01BX000273Apr 1, 2009 - Sep 30, 2017
    Role: Principal Investigator
    Epileptogenesis after febrile status epilepticus: a role of hyperthermia
    NIH/NINDS R21NS059704May 15, 2008 - Apr 30, 2011
    Role: Principal Investigator
    Brain development in experimental epilepsy
    NIH/NINDS R01NS013515Dec 1, 1978 - Nov 30, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baumhefner R, Wasterlain C, Mishra S, Murthy K. In Memory of Wallace William Tourtellotte, MD, PhD (1924-2019). Ann Neurol. 2020 Feb; 87(2):170-171. PMID: 31875425.
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    2. Niquet J, Lumley L, Baldwin R, Rossetti F, Schultz M, de Araujo Furtado M, Suchomelova L, Naylor D, Franco-Estrada I, Wasterlain CG. Early polytherapy for benzodiazepine-refractory status epilepticus. Epilepsy Behav. 2019 Dec; 101(Pt B):106367. PMID: 31636007.
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    3. Lumley LA, Rossetti F, de Araujo Furtado M, Marrero-Rosado B, Schultz CR, Schultz MK, Niquet J, Wasterlain CG. Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats. Data Brief. 2019 Dec; 27:104629. PMID: 31687442.
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    4. Niquet J, Lumley L, Baldwin R, Rossetti F, Suchomelova L, Naylor D, Estrada IBF, Schultz M, Furtado MA, Wasterlain CG. Rational polytherapy in the treatment of cholinergic seizures. Neurobiol Dis. 2020 Jan; 133:104537. PMID: 31454548.
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    5. Thompson KW, Suchomelova L, Wasterlain CG. Treatment of early life status epilepticus: What can we learn from animal models? Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):169-179. PMID: 30564776.
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    6. Torolira D, Suchomelova L, Wasterlain CG, Niquet J. Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury. Ann Neurol. 2017 Jul; 82(1):115-120. PMID: 28556259.
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    7. Niquet J, Suchomelova L, Thompson K, Klitgaard H, Matagne A, Wasterlain C. Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. Epilepsia. 2017 07; 58(7):1199-1207. PMID: 28597912.
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    8. Dingledine R, Coulter DA, Fritsch B, Gorter JA, Lelutiu N, McNamara J, Nadler JV, Pitkänen A, Rogawski MA, Skene P, Sloviter RS, Wang Y, Wadman WJ, Wasterlain C, Roopra A. Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models. Sci Data. 2017 05 09; 4:170061. PMID: 28485718.
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    9. Niquet J, Baldwin R, Norman K, Suchomelova L, Lumley L, Wasterlain CG. Simultaneous triple therapy for the treatment of status epilepticus. Neurobiol Dis. 2017 Aug; 104:41-49. PMID: 28461248.
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    10. Niquet J, Baldwin R, Suchomelova L, Lumley L, Eavey R, Wasterlain CG. Treatment of experimental status epilepticus with synergistic drug combinations. Epilepsia. 2017 04; 58(4):e49-e53. PMID: 28225161.
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    11. Niquet J, Baldwin R, Norman K, Suchomelova L, Lumley L, Wasterlain CG. Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits. Epilepsia. 2016 09; 57(9):1406-15. PMID: 27500978.
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    12. Niquet J, Baldwin R, Suchomelova L, Lumley L, Naylor D, Eavey R, Wasterlain CG. Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment. Ann N Y Acad Sci. 2016 08; 1378(1):166-173. PMID: 27392038.
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    13. Torolira D, Suchomelova L, Wasterlain CG, Niquet J. Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups. Epilepsy Res. 2016 Feb; 120:47-54. PMID: 26709882.
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    14. Niquet J, Gezalian M, Baldwin R, Wasterlain CG. Neuroprotective effects of deep hypothermia in refractory status epilepticus. Ann Clin Transl Neurol. 2015 12; 2(12):1105-15. PMID: 26734661.
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    15. Niquet J, Baldwin R, Gezalian M, Wasterlain CG. Deep hypothermia for the treatment of refractory status epilepticus. Epilepsy Behav. 2015 Aug; 49:313-7. PMID: 26198217.
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    16. Benz AP, Niquet J, Wasterlain CG, Rami A. Status epilepticus in the immature rodent brain alters the dynamics of autophagy. Curr Neurovasc Res. 2014 May; 11(2):125-35. PMID: 24597603.
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    17. Wasterlain CG, Naylor DE, Liu H, Niquet J, Baldwin R. Trafficking of NMDA receptors during status epilepticus: therapeutic implications. Epilepsia. 2013 Sep; 54 Suppl 6:78-80. PMID: 24001081.
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    18. Naylor DE, Liu H, Niquet J, Wasterlain CG. Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiol Dis. 2013 Jun; 54:225-38. PMID: 23313318.
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    19. Wasterlain CG, Gloss DS, Niquet J, Wasterlain AS. Epileptogenesis in the developing brain. Handb Clin Neurol. 2013; 111:427-39. PMID: 23622191.
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    20. Wasterlain CG, Baldwin R, Naylor DE, Thompson KW, Suchomelova L, Niquet J. Rational polytherapy in the treatment of acute seizures and status epilepticus. Epilepsia. 2011 Oct; 52 Suppl 8:70-1. PMID: 21967369.
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    21. Wasterlain CG, Stöhr T, Matagne A. The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus. Epilepsy Res. 2011 Mar; 94(1-2):10-7. PMID: 21277168.
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    22. Wasterlain CG, Thompson KW, Suchomelova L, Niquet J. Brain energy metabolism during experimental neonatal seizures. Neurochem Res. 2010 Dec; 35(12):2193-8. PMID: 21136154.
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    23. Lu X, Roberts E, Xia F, Sanchez-Alavez M, Liu T, Baldwin R, Wu S, Chang J, Wasterlain CG, Bartfai T. GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15229-34. PMID: 20660766.
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    24. Lopez-Meraz ML, Niquet J, Wasterlain CG. Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus. Epilepsia. 2010 Jul; 51 Suppl 3:56-60. PMID: 20618402.
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    25. Pedersen ME, Baldwin RA, Niquet J, Stafford GI, van Staden J, Wasterlain CG, Jäger AK. Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats. Phytother Res. 2010 Jun; 24(6):924-7. PMID: 19953526.
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    26. Wasterlain CG, Liu H, Naylor DE, Thompson KW, Suchomelova L, Niquet J, Mazarati AM, Baldwin RA. Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited. Epilepsia. 2009 Dec; 50 Suppl 12:16-8. PMID: 19941513.
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    27. Lopez-Meraz ML, Wasterlain CG, Rocha LL, Allen S, Niquet J. Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage. Neurobiol Dis. 2010 Feb; 37(2):394-402. PMID: 19879360.
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    28. Seo DW, Lopez-Meraz ML, Allen S, Wasterlain CG, Niquet J. Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis. J Neurosci Res. 2009 Jul; 87(9):2087-94. PMID: 19235896.
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    29. Chen JW, Ruff RL, Eavey R, Wasterlain CG. Posttraumatic epilepsy and treatment. J Rehabil Res Dev. 2009; 46(6):685-96. PMID: 20104398.
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    30. Wasterlain CG, Chen JW. Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs. Epilepsia. 2008 Dec; 49 Suppl 9:63-73. PMID: 19087119.
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    31. Rocha LL, Lopez-Meraz ML, Niquet J, Wasterlain CG. Do single seizures cause neuronal death in the human hippocampus? Epilepsy Curr. 2007 May-Jun; 7(3):77-81. PMID: 17520081.
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    32. Niquet J, Auvin S, Archie M, Seo DW, Allen S, Sankar R, Wasterlain CG. Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain. Epilepsia. 2007 Jun; 48(6):1203-6. PMID: 17441993.
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    33. Pereira de Vasconcelos A, Riban V, Wasterlain C, Nehlig A. Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: a genetic approach using knockout mice. Neurobiol Dis. 2006 Jul; 23(1):219-27. PMID: 16690320.
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    34. Chen JW, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol. 2006 Mar; 5(3):246-56. PMID: 16488380.
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    35. Suchomelova L, Baldwin RA, Kubova H, Thompson KW, Sankar R, Wasterlain CG. Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects. Pediatr Res. 2006 Feb; 59(2):237-43. PMID: 16439585.
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    36. Naylor DE, Liu H, Wasterlain CG. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci. 2005 Aug 24; 25(34):7724-33. PMID: 16120773.
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    37. de Vasconcelos AP, Bouilleret V, Riban V, Wasterlain C, Nehlig A. Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches. Neurobiol Dis. 2005 Mar; 18(2):270-81. PMID: 15686955.
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    38. Niquet J, Liu H, Wasterlain CG. Programmed neuronal necrosis and status epilepticus. Epilepsia. 2005; 46 Suppl 5:43-8. PMID: 15987252.
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    39. Naylor DE, Wasterlain CG. GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation. Epilepsia. 2005; 46 Suppl 5:142-7. PMID: 15987269.
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    40. Mazarati A, Lu X, Kilk K, Langel U, Wasterlain C, Bartfai T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci. 2004 Jun; 19(12):3235-44. PMID: 15217380.
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    41. Niquet J, Wasterlain CG. Bim, Bad, and Bax: a deadly combination in epileptic seizures. J Clin Invest. 2004 Apr; 113(7):960-2. PMID: 15057301.
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    42. Niquet J, Allen SG, Baldwin RA, Wasterlain CG. Evidence of caspase-3 activation in hyposmotic stress-induced necrosis. Neurosci Lett. 2004 Feb 19; 356(3):225-7. PMID: 15036635.
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    43. Mazarati AM, Baldwin R, Klitgaard H, Matagne A, Wasterlain CG. Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res. 2004 Feb; 58(2-3):167-74. PMID: 15120747.
      View in: PubMed
    44. Sankar R, Shin D, Wasterlain CG. Development of temporal lobe epilepsy in 21-day-old rats. Epilepsia. 2003 Jun; 44(6):872; author reply 872-3. PMID: 12790906.
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    45. Niquet J, Baldwin RA, Allen SG, Fujikawa DG, Wasterlain CG. Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2825-30. PMID: 12606726.
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    46. Mazarati A, Wasterlain CG. Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus. Neurosci Lett. 2002 Oct 11; 331(2):123-7. PMID: 12361856.
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    47. Mazarati AM, Sofia RD, Wasterlain CG. Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. Seizure. 2002 Oct; 11(7):423-30. PMID: 12237067.
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    48. Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7136-41. PMID: 12011470.
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    49. Tan Z, Sankar R, Tu W, Shin D, Liu H, Wasterlain CG, Schreiber SS. Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. Brain Res. 2002 Mar 01; 929(1):129-38. PMID: 11852039.
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    50. Tan Z, Sankar R, Shin D, Sun N, Liu H, Wasterlain CG, Schreiber SS. Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. Brain Res. 2002 Feb 22; 928(1-2):187-93. PMID: 11844486.
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    51. Wasterlain CG, Niquet J, Thompson KW, Baldwin R, Liu H, Sankar R, Mazarati AM, Naylor D, Katsumori H, Suchomelova L, Shirasaka Y. Seizure-induced neuronal death in the immature brain. Prog Brain Res. 2002; 135:335-53. PMID: 12143353.
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    52. Wasterlain CG, Mazarati AM, Naylor D, Niquet J, Liu H, Suchomelova L, Baldwin R, Katsumori H, Shirasaka Y, Shin D, Sankar R. Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus. Epilepsia. 2002; 43 Suppl 5:20-9. PMID: 12121290.
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    53. Sankar R, Shin D, Liu H, Wasterlain C, Mazarati A. Epileptogenesis during development: injury, circuit recruitment, and plasticity. Epilepsia. 2002; 43 Suppl 5:47-53. PMID: 12121295.
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    54. Mazarati A, Bragin A, Baldwin R, Shin D, Wilson C, Sankar R, Naylor D, Engel J, Wasterlain CG. Epileptogenesis after self-sustaining status epilepticus. Epilepsia. 2002; 43 Suppl 5:74-80. PMID: 12121299.
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    55. Wasterlain CG, Liu H, Mazarati AM, Baldwin RA, Shirasaka Y, Katsumori H, Thompson KW, Sankar R, Pereira de Vasconselos A, Nehlig A. Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators. Epilepsia. 2000; 41 Suppl 6:S134-43. PMID: 10999535.
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