Claude G Wasterlain

Title(s)Professor-in-Residence, Neurology
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    Rational polytherapy in the treatment of cholinergic seizures
    NIH U01NS074926Sep 15, 2011 - Aug 31, 2018
    Role: Principal Investigator
    Treatment of status epilepticus: a translational proposal.
    NIH I01BX000273Apr 1, 2009 - Sep 30, 2017
    Role: Principal Investigator
    Epileptogenesis after febrile status epilepticus: a role of hyperthermia
    NIH R21NS059704May 15, 2008 - Apr 30, 2011
    Role: Principal Investigator
    Brain development in experimental epilepsy
    NIH R01NS013515Dec 1, 1978 - Jan 31, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman-induced epileptogenesis and brain pathology in rats. Epilepsia Open. 2021 Oct 17. Lumley LA, Marrero-Rosado B, Rossetti F, Schultz CR, Stone MF, Niquet J, Wasterlain CG. PMID: 34657398.
      View in: PubMed   Mentions:
    2. Treatment of acetylcholinesterase inhibitor-induced seizures with polytherapy targeting GABA and glutamate receptors. Neuropharmacology. 2021 03 01; 185:108444. Lumley L, Niquet J, Marrero-Rosado B, Schultz M, Rossetti F, de Araujo Furtado M, Wasterlain C. PMID: 33359073.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    3. In Memory of Wallace William Tourtellotte, MD, PhD (1924-2019). Ann Neurol. 2020 02; 87(2):170-171. Baumhefner R, Wasterlain C, Mishra S, Murthy K. PMID: 31875425.
      View in: PubMed   Mentions:    Fields:    
    4. Early polytherapy for benzodiazepine-refractory status epilepticus. Epilepsy Behav. 2019 12; 101(Pt B):106367. Niquet J, Lumley L, Baldwin R, Rossetti F, Schultz M, de Araujo Furtado M, Suchomelova L, Naylor D, Franco-Estrada I, Wasterlain CG. PMID: 31636007.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    5. Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats. Data Brief. 2019 Dec; 27:104629. Lumley LA, Rossetti F, de Araujo Furtado M, Marrero-Rosado B, Schultz CR, Schultz MK, Niquet J, Wasterlain CG. PMID: 31687442.
      View in: PubMed   Mentions: 5  
    6. Rational polytherapy in the treatment of cholinergic seizures. Neurobiol Dis. 2020 01; 133:104537. Niquet J, Lumley L, Baldwin R, Rossetti F, Suchomelova L, Naylor D, Estrada IBF, Schultz M, Furtado MA, Wasterlain CG. PMID: 31454548.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    7. Treatment of early life status epilepticus: What can we learn from animal models? Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):169-179. Thompson KW, Suchomelova L, Wasterlain CG. PMID: 30564776.
      View in: PubMed   Mentions:
    8. Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury. Ann Neurol. 2017 Jul; 82(1):115-120. Torolira D, Suchomelova L, Wasterlain CG, Niquet J. PMID: 28556259.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    9. Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. Epilepsia. 2017 07; 58(7):1199-1207. Niquet J, Suchomelova L, Thompson K, Klitgaard H, Matagne A, Wasterlain C. PMID: 28597912.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    10. Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models. Sci Data. 2017 05 09; 4:170061. Dingledine R, Coulter DA, Fritsch B, Gorter JA, Lelutiu N, McNamara J, Nadler JV, Pitkänen A, Rogawski MA, Skene P, Sloviter RS, Wang Y, Wadman WJ, Wasterlain C, Roopra A. PMID: 28485718.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    11. Simultaneous triple therapy for the treatment of status epilepticus. Neurobiol Dis. 2017 Aug; 104:41-49. Niquet J, Baldwin R, Norman K, Suchomelova L, Lumley L, Wasterlain CG. PMID: 28461248.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. Treatment of experimental status epilepticus with synergistic drug combinations. Epilepsia. 2017 04; 58(4):e49-e53. Niquet J, Baldwin R, Suchomelova L, Lumley L, Eavey R, Wasterlain CG. PMID: 28225161.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    13. Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits. Epilepsia. 2016 09; 57(9):1406-15. Niquet J, Baldwin R, Norman K, Suchomelova L, Lumley L, Wasterlain CG. PMID: 27500978.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    14. Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment. Ann N Y Acad Sci. 2016 08; 1378(1):166-173. Niquet J, Baldwin R, Suchomelova L, Lumley L, Naylor D, Eavey R, Wasterlain CG. PMID: 27392038.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    15. Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups. Epilepsy Res. 2016 Feb; 120:47-54. Torolira D, Suchomelova L, Wasterlain CG, Niquet J. PMID: 26709882.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Neuroprotective effects of deep hypothermia in refractory status epilepticus. Ann Clin Transl Neurol. 2015 12; 2(12):1105-15. Niquet J, Gezalian M, Baldwin R, Wasterlain CG. PMID: 26734661.
      View in: PubMed   Mentions: 2     Fields:    
    17. Deep hypothermia for the treatment of refractory status epilepticus. Epilepsy Behav. 2015 Aug; 49:313-7. Niquet J, Baldwin R, Gezalian M, Wasterlain CG. PMID: 26198217.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. Status epilepticus in the immature rodent brain alters the dynamics of autophagy. Curr Neurovasc Res. 2014 May; 11(2):125-35. Benz AP, Niquet J, Wasterlain CG, Rami A. PMID: 24597603.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    19. Trafficking of NMDA receptors during status epilepticus: therapeutic implications. Epilepsia. 2013 Sep; 54 Suppl 6:78-80. Wasterlain CG, Naylor DE, Liu H, Niquet J, Baldwin R. PMID: 24001081.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiol Dis. 2013 Jun; 54:225-38. Naylor DE, Liu H, Niquet J, Wasterlain CG. PMID: 23313318.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    21. Epileptogenesis in the developing brain. Handb Clin Neurol. 2013; 111:427-39. Wasterlain CG, Gloss DS, Niquet J, Wasterlain AS. PMID: 23622191.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Rational polytherapy in the treatment of acute seizures and status epilepticus. Epilepsia. 2011 Oct; 52 Suppl 8:70-1. Wasterlain CG, Baldwin R, Naylor DE, Thompson KW, Suchomelova L, Niquet J. PMID: 21967369.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    23. The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus. Epilepsy Res. 2011 Mar; 94(1-2):10-7. Wasterlain CG, Stöhr T, Matagne A. PMID: 21277168.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    24. Brain energy metabolism during experimental neonatal seizures. Neurochem Res. 2010 Dec; 35(12):2193-8. Wasterlain CG, Thompson KW, Suchomelova L, Niquet J. PMID: 21136154.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    25. GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15229-34. Lu X, Roberts E, Xia F, Sanchez-Alavez M, Liu T, Baldwin R, Wu S, Chang J, Wasterlain CG, Bartfai T. PMID: 20660766.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    26. Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus. Epilepsia. 2010 Jul; 51 Suppl 3:56-60. Lopez-Meraz ML, Niquet J, Wasterlain CG. PMID: 20618402.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    27. Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats. Phytother Res. 2010 Jun; 24(6):924-7. Pedersen ME, Baldwin RA, Niquet J, Stafford GI, van Staden J, Wasterlain CG, Jäger AK. PMID: 19953526.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    28. Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited. Epilepsia. 2009 Dec; 50 Suppl 12:16-8. Wasterlain CG, Liu H, Naylor DE, Thompson KW, Suchomelova L, Niquet J, Mazarati AM, Baldwin RA. PMID: 19941513.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage. Neurobiol Dis. 2010 Feb; 37(2):394-402. Lopez-Meraz ML, Wasterlain CG, Rocha LL, Allen S, Niquet J. PMID: 19879360.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    30. Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis. J Neurosci Res. 2009 Jul; 87(9):2087-94. Seo DW, Lopez-Meraz ML, Allen S, Wasterlain CG, Niquet J. PMID: 19235896.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. Posttraumatic epilepsy and treatment. J Rehabil Res Dev. 2009; 46(6):685-96. Chen JW, Ruff RL, Eavey R, Wasterlain CG. PMID: 20104398.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    32. Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs. Epilepsia. 2008 Dec; 49 Suppl 9:63-73. Wasterlain CG, Chen JW. PMID: 19087119.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    33. Do single seizures cause neuronal death in the human hippocampus? Epilepsy Curr. 2007 May-Jun; 7(3):77-81. Rocha LL, Lopez-Meraz ML, Niquet J, Wasterlain CG. PMID: 17520081.
      View in: PubMed   Mentions: 5  
    34. Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain. Epilepsia. 2007 Jun; 48(6):1203-6. Niquet J, Auvin S, Archie M, Seo DW, Allen S, Sankar R, Wasterlain CG. PMID: 17441993.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    35. Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: a genetic approach using knockout mice. Neurobiol Dis. 2006 Jul; 23(1):219-27. Pereira de Vasconcelos A, Riban V, Wasterlain C, Nehlig A. PMID: 16690320.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    36. Status epilepticus: pathophysiology and management in adults. Lancet Neurol. 2006 Mar; 5(3):246-56. Chen JW, Wasterlain CG. PMID: 16488380.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    37. Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects. Pediatr Res. 2006 Feb; 59(2):237-43. Suchomelova L, Baldwin RA, Kubova H, Thompson KW, Sankar R, Wasterlain CG. PMID: 16439585.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    38. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci. 2005 Aug 24; 25(34):7724-33. Naylor DE, Liu H, Wasterlain CG. PMID: 16120773.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    39. Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches. Neurobiol Dis. 2005 Mar; 18(2):270-81. de Vasconcelos AP, Bouilleret V, Riban V, Wasterlain C, Nehlig A. PMID: 15686955.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    40. Programmed neuronal necrosis and status epilepticus. Epilepsia. 2005; 46 Suppl 5:43-8. Niquet J, Liu H, Wasterlain CG. PMID: 15987252.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    41. GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation. Epilepsia. 2005; 46 Suppl 5:142-7. Naylor DE, Wasterlain CG. PMID: 15987269.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    42. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci. 2004 Jun; 19(12):3235-44. Mazarati A, Lu X, Kilk K, Langel U, Wasterlain C, Bartfai T. PMID: 15217380.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    43. Bim, Bad, and Bax: a deadly combination in epileptic seizures. J Clin Invest. 2004 Apr; 113(7):960-2. Niquet J, Wasterlain CG. PMID: 15057301.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    44. Evidence of caspase-3 activation in hyposmotic stress-induced necrosis. Neurosci Lett. 2004 Feb 19; 356(3):225-7. Niquet J, Allen SG, Baldwin RA, Wasterlain CG. PMID: 15036635.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res. 2004 Feb; 58(2-3):167-74. Mazarati AM, Baldwin R, Klitgaard H, Matagne A, Wasterlain CG. PMID: 15120747.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    46. Development of temporal lobe epilepsy in 21-day-old rats. Epilepsia. 2003 Jun; 44(6):872; author reply 872-3. Sankar R, Shin D, Wasterlain CG. PMID: 12790906.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    47. Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2825-30. Niquet J, Baldwin RA, Allen SG, Fujikawa DG, Wasterlain CG. PMID: 12606726.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    48. Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus. Neurosci Lett. 2002 Oct 11; 331(2):123-7. Mazarati A, Wasterlain CG. PMID: 12361856.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    49. Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. Seizure. 2002 Oct; 11(7):423-30. Mazarati AM, Sofia RD, Wasterlain CG. PMID: 12237067.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    50. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7136-41. Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U. PMID: 12011470.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    51. Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. Brain Res. 2002 Mar 01; 929(1):129-38. Tan Z, Sankar R, Tu W, Shin D, Liu H, Wasterlain CG, Schreiber SS. PMID: 11852039.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    52. Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. Brain Res. 2002 Feb 22; 928(1-2):187-93. Tan Z, Sankar R, Shin D, Sun N, Liu H, Wasterlain CG, Schreiber SS. PMID: 11844486.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Seizure-induced neuronal death in the immature brain. Prog Brain Res. 2002; 135:335-53. Wasterlain CG, Niquet J, Thompson KW, Baldwin R, Liu H, Sankar R, Mazarati AM, Naylor D, Katsumori H, Suchomelova L, Shirasaka Y. PMID: 12143353.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    54. Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus. Epilepsia. 2002; 43 Suppl 5:20-9. Wasterlain CG, Mazarati AM, Naylor D, Niquet J, Liu H, Suchomelova L, Baldwin R, Katsumori H, Shirasaka Y, Shin D, Sankar R. PMID: 12121290.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    55. Epileptogenesis during development: injury, circuit recruitment, and plasticity. Epilepsia. 2002; 43 Suppl 5:47-53. Sankar R, Shin D, Liu H, Wasterlain C, Mazarati A. PMID: 12121295.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. Epileptogenesis after self-sustaining status epilepticus. Epilepsia. 2002; 43 Suppl 5:74-80. Mazarati A, Bragin A, Baldwin R, Shin D, Wilson C, Sankar R, Naylor D, Engel J, Wasterlain CG. PMID: 12121299.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    57. Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators. Epilepsia. 2000; 41 Suppl 6:S134-43. Wasterlain CG, Liu H, Mazarati AM, Baldwin RA, Shirasaka Y, Katsumori H, Thompson KW, Sankar R, Pereira de Vasconselos A, Nehlig A. PMID: 10999535.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
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