Dale Eric Bredesen

Title(s)Professor-in-Residence, Molecular and Medical Pharmacology
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    APP signaling network
    NIH R21AG036975Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Novel Prionic Mechanism Underlying Alzheimer?s Disease
    NIH R01AG034427Jul 15, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Development and Improvement of an Animal Resource Core
    NIH G20RR022770Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator
    Basic Mechanisms in Aging and Age Related Disease
    NIH P30AG025708Jul 1, 2005 - Jun 30, 2011
    Role: Co-Principal Investigator
    Buck Institute--Pharmacology of Lifespan Extension
    NIH R13AG026961Jun 1, 2005 - May 31, 2006
    Role: Principal Investigator
    Center for Integrative Studies of Aging
    NIH C06RR020660Sep 30, 2004 - Jun 30, 2009
    Role: Principal Investigator
    Mechanism of apoptosis induction by the receptor DCC
    NIH R01NS045093Feb 1, 2003 - Jan 31, 2008
    Role: Principal Investigator
    Training in Age-Related Disease and Aging Research
    NIH T32AG020495May 1, 2002 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Alzheimer's Disease Research Center
    NIH P50AG016570Apr 5, 1999 - Mar 31, 2016
    Role: Principal Investigator
    Apoptosis: Basic Mechanisms and Disease Relevance
    NIH T32AG000252Jun 15, 1997 - Apr 30, 2004
    Role: Co-Principal Investigator
    FAMILIAL ALS--MECHANISM OF INITIATION
    NIH R01NS035155Jun 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Novel apoptotic pathway activated by misfolded proteins
    NIH R01NS033376Jan 1, 1997 - Jun 30, 2008
    Role: Principal Investigator
    Mechanism of inhibition of neurodegeneration and aging
    NIH R01AG012282May 1, 1994 - Mar 31, 2008
    Role: Principal Investigator
    A GENETICALLY TRACTABLE IN VITRO MODEL OF AD
    NIH R01AG010671Sep 29, 1991 - Jun 30, 1994
    Role: Principal Investigator
    MOLECULAR EFFECTS OF SPECIFIC HIV PROTEINS ON THE CNS
    NIH R29NS027812Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    ANALYSIS OF THE PEP GENE IN NZW AND I/LNJ
    NIH F32NS008100Feb 28, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review. Int J Mol Sci. 2023 Jan 14; 24(2). Rao RV, Subramaniam KG, Gregory J, Bredesen AL, Coward C, Okada S, Kelly L, Bredesen DE. PMID: 36675177.
      View in: PubMed   Mentions: 1     Fields:    
    2. Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? Am J Clin Nutr. 2023 Mar; 117(3):455-466. Johnson RJ, Tolan DR, Bredesen D, Nagel M, Sánchez-Lozada LG, Fini M, Burtis S, Lanaspa MA, Perlmutter D. PMID: 36774227.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project. J Alzheimers Dis. 2022; 88(4):1411-1421. Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE. PMID: 35811518; PMCID: PMC9484109.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline. Biomedicines. 2021 Sep 29; 9(10). Rao RV, Kumar S, Gregory J, Coward C, Okada S, Lipa W, Kelly L, Bredesen DE. PMID: 34680464; PMCID: PMC8533598.
      View in: PubMed   Mentions: 3  
    5. Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease. J Alzheimers Dis Parkinsonism. 2021; 11(Suppl 5). Ross MK, Raji C, Lokken KL, Bredesen DE, Roach JC, Funk CC, Price N, Rappaport N, Hood L, Heath JR. PMID: 35237464; PMCID: PMC8887953.
      View in: PubMed   Mentions:
    6. Neuroprotective Herbs for the Management of Alzheimer's Disease. Biomolecules. 2021 04 08; 11(4). Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. PMID: 33917843; PMCID: PMC8068256.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    7. Alzheimer's disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics. Aging (Albany NY). 2020 Sep 21; 12(18):17815-17844. Kurakin A, Bredesen DE. PMID: 32957083; PMCID: PMC7585078.
      View in: PubMed   Mentions: 3     Fields:    
    8. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 12 04; 8(1):17574. Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, Cole G, LaDu MJ, Jung ME, Bredesen DE, John V. PMID: 30514854; PMCID: PMC6279743.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    9. Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease. Mol Neurobiol. 2018 Jun; 55(6):5243-5254. Theendakara V, Peters-Libeu CA, Bredesen DE, Rao RV. PMID: 28879423.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    10. Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease. Mol Cell Neurosci. 2017 09; 83:83-91. Theendakara V, Bredesen DE, Rao RV. PMID: 28720530.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    11. Ayurvedic Profiling of Alzheimer's Disease. Altern Ther Health Med. 2017 May; 23(3):46-50. Bredesen DE, Rao RV. PMID: 28236613.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017; 8:46. Poksay KS, Sheffler DJ, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. PMID: 28261092; PMCID: PMC5309220.
      View in: PubMed   Mentions: 1  
    13. Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation. FASEB J. 2017 01; 31(1):148-160. Famenini S, Rigali EA, Olivera-Perez HM, Dang J, Chang MT, Halder R, Rao RV, Pellegrini M, Porter V, Bredesen D, Fiala M. PMID: 27677546; PMCID: PMC5161513.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    14. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 06; 8(6):1250-8. Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. PMID: 27294343; PMCID: PMC4931830.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    15. Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 03 08; 52(1):223-42. Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. PMID: 27060954.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic. Aging (Albany NY). 2016 Feb; 8(2):304-13. Bredesen DE. PMID: 26870879; PMCID: PMC4789584.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    17. Direct Transcriptional Effects of Apolipoprotein E. J Neurosci. 2016 Jan 20; 36(3):685-700. Theendakara V, Peters-Libeu CA, Spilman P, Poksay KS, Bredesen DE, Rao RV. PMID: 26791201; PMCID: PMC4719010.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    18. Metabolic profiling distinguishes three subtypes of Alzheimer's disease. Aging (Albany NY). 2015 Aug; 7(8):595-600. Bredesen DE. PMID: 26343025; PMCID: PMC4586104.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    19. Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget. 2015 Jun 10; 6(16):14092-122. Kurakin A, Bredesen DE. PMID: 26041885; PMCID: PMC4546454.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline. AJNR Am J Neuroradiol. 2015 Oct; 36(10):1803-9. Raji CA, Eyre H, Wei SH, Bredesen DE, Moylan S, Law M, Small G, Thompson PM, Friedlander RM, Silverman DH, Baune BT, Hoang TA, Salamon N, Toga AW, Vernooij MW. PMID: 26045577; PMCID: PMC4600413.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul; 29(7):2681-9. Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. PMID: 25805829.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    22. Correction to hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2015 Feb 26; 58(4):2045. Ellerby HM, Bredesen DE, Fujimura S, John V. PMID: 25668572.
      View in: PubMed   Mentions:    Fields:    
    23. Alzheimer's Model Develops Early ADHD Syndrome. J Neurol Neurophysiol. 2015; 6(6):1-6. Zhang Q, Du G, John V, Kapahi P, Bredesen DE. PMID: 26753104; PMCID: PMC4704098.
      View in: PubMed   Mentions: 7  
    24. sAβPPα is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis. 2015; 47(3):545-55. Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. PMID: 26401691.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    25. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan; 22(1):58-73. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. PMID: 25236395; PMCID: PMC4262782.
      View in: PubMed   Mentions: 378     Fields:    Translation:HumansAnimalsCells
    26. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep; 6(9):707-17. Bredesen DE. PMID: 25324467; PMCID: PMC4221920.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCTClinical Trials
    27. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617. Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. PMID: 24531152; PMCID: PMC4091737.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014 Mar 10; 1551:25-44. Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. PMID: 24389031; PMCID: PMC4001856.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8. Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. PMID: 24145446; PMCID: PMC3831497.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    30. Next generation therapeutics for Alzheimer's disease. EMBO Mol Med. 2013 Jun; 5(6):795-8. Bredesen DE, John V. PMID: 23703924; PMCID: PMC3779441.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    31. AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. J Alzheimers Dis. 2013; 37(2):343-55. Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. PMID: 23948888; PMCID: PMC3971881.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21; 32(47):16775-84. Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. PMID: 23175831; PMCID: PMC3736741.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    33. mCiRNA-synaptic crystal ball? Aging (Albany NY). 2012 Nov; 4(11):732-3. Bredesen D. PMID: 23241907; PMCID: PMC3560433.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. The small co-chaperone p23 overexpressing transgenic mouse. J Neurosci Methods. 2013 Jan 30; 212(2):190-4. Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV. PMID: 23022695; PMCID: PMC3562756.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    35. Moonlighting peptides with emerging function. PLoS One. 2012; 7(7):e40125. Rodríguez Plaza JG, Villalón Rojas A, Herrera S, Garza-Ramos G, Torres Larios A, Amero C, Zarraga Granados G, Gutiérrez Aguilar M, Lara Ortiz MT, Polanco Gonzalez C, Uribe Carvajal S, Coria R, Peña Díaz A, Bredesen DE, Castro-Obregon S, del Rio G. PMID: 22808104; PMCID: PMC3396687.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther. 2012 Jun 29; 4(3):22. Rao RV, Descamps O, John V, Bredesen DE. PMID: 22747839; PMCID: PMC3506936.
      View in: PubMed   Mentions: 36     Fields:    
    37. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012; 7(6):e40027. Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE. PMID: 22768208; PMCID: PMC3386930.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis? Antioxid Redox Signal. 2012 Dec 01; 17(11):1507-14. Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA. PMID: 22500616; PMCID: PMC3448937.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    39. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One. 2011; 6(12):e28530. Madden DT, Davila-Kruger D, Melov S, Bredesen DE. PMID: 22174832; PMCID: PMC3235131.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    40. The small chaperone protein p23 and its cleaved product p19 in cellular stress. J Mol Neurosci. 2012 Feb; 46(2):303-14. Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV. PMID: 21691801; PMCID: PMC3246043.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    41. Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging Dis. 2011 Feb; 2(1):18-29. Zhang J, Rao RV, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE, Galvan V. PMID: 21874159; PMCID: PMC3160738.
      View in: PubMed   Mentions: 2  
    42. Dependence receptors: from basic research to drug development. Sci Signal. 2011 Jan 25; 4(157):mr2. Mehlen P, Bredesen DE. PMID: 21266712.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    43. Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration. J Mol Neurosci. 2011 Jun; 44(2):91-102. Poksay KS, Madden DT, Peter AK, Niazi K, Banwait S, Crippen D, Bredesen DE, Rao RV. PMID: 21249466; PMCID: PMC3084943.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Neuroscience. 2011 Mar 17; 177:207-22. Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA. PMID: 21223993; PMCID: PMC3058851.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    45. Signaling via amyloid precursor-like proteins APLP1 and APLP2. J Alzheimers Dis. 2011; 23(4):689-99. Orcholski ME, Zhang Q, Bredesen DE. PMID: 21178287.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Induction of the C-terminal proteolytic cleavage of AβPP by statins. J Alzheimers Dis. 2011; 25(1):51-7. Descamps O, Zhang Q, John V, Bredesen DE. PMID: 21422530.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    47. Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimers Dis. 2011; 25(3):547-66. Libeu CP, Poksay KS, John V, Bredesen DE. PMID: 21471643; PMCID: PMC4001850.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    48. Identification of new modulators and protein alterations in non-apoptotic programmed cell death. J Cell Biochem. 2010 Dec 15; 111(6):1401-12. Sperandio S, Poksay KS, Schilling B, Crippen D, Gibson BW, Bredesen DE. PMID: 20830744; PMCID: PMC5668132.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    49. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 01; 5(4):e9979. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. PMID: 20376313; PMCID: PMC2848616.
      View in: PubMed   Mentions: 520     Fields:    Translation:AnimalsCells
    50. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci. 2010 Jan 06; 30(1):372-81. Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. PMID: 20053918; PMCID: PMC3064502.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    51. Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis. 2010; 22(1):57-63. Bredesen DE, John V, Galvan V. PMID: 20847422; PMCID: PMC3968071.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    52. Novel mediators of amyloid precursor protein signaling. J Neurosci. 2009 Dec 16; 29(50):15703-12. Swistowski A, Zhang Q, Orcholski ME, Crippen D, Vitelli C, Kurakin A, Bredesen DE. PMID: 20016085; PMCID: PMC2823633.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    53. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free Radic Biol Med. 2010 Jan 01; 48(1):136-44. Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. PMID: 19854267; PMCID: PMC2818480.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    54. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 2011 Sep; 32(9):1725-9. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. PMID: 19828212; PMCID: PMC2889215.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    55. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res. 2010 Jan 20; 206(2):202-7. Zhang J, Gorostiza OF, Tang H, Bredesen DE, Galvan V. PMID: 19751769; PMCID: PMC2783897.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    56. Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):450-5. Park SA, Shaked GM, Bredesen DE, Koo EH. PMID: 19679105; PMCID: PMC2838490.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    57. Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener. 2009 Jun 26; 4:27. Bredesen DE. PMID: 19558683; PMCID: PMC2709109.
      View in: PubMed   Mentions: 41     Fields:    
    58. Interfering with multimerization of netrin-1 receptors triggers tumor cell death. Cell Death Differ. 2009 Oct; 16(10):1344-51. Mille F, Llambi F, Guix C, Delloye-Bourgeois C, Guenebeaud C, Castro-Obregon S, Bredesen DE, Thibert C, Mehlen P. PMID: 19543238; PMCID: PMC2841642.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    59. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug; 16(8):1093-107. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. PMID: 19373242; PMCID: PMC2757140.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansCells
    60. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol. 2009 Mar; 65(3):294-303. Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE. PMID: 19334058; PMCID: PMC3057030.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    61. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell Death Differ. 2009 May; 16(5):655-63. Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, Bredesen DE, Mehlen P. PMID: 19148186; PMCID: PMC2757418.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    62. Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci. 2009 Sep; 39(1-2):157-68. Chinta SJ, Poksay KS, Kaundinya G, Hart M, Bredesen DE, Andersen JK, Rao RV. PMID: 19145491; PMCID: PMC2745484.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    63. Hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2008 Oct 09; 51(19):5887-92. Ellerby HM, Bredesen DE, Fujimura S, John V. PMID: 18828573.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    64. Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat. Neuromolecular Med. 2008; 10(4):333-42. Chinta SJ, Rane A, Poksay KS, Bredesen DE, Andersen JK, Rao RV. PMID: 18773310; PMCID: PMC2818083.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    65. Focal degeneration of astrocytes in amyotrophic lateral sclerosis. Cell Death Differ. 2008 Nov; 15(11):1691-700. Rossi D, Brambilla L, Valori CF, Roncoroni C, Crugnola A, Yokota T, Bredesen DE, Volterra A. PMID: 18617894.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    66. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis. 2008 Jul; 13(7):904-14. Bakhshi J, Weinstein L, Poksay KS, Nishinaga B, Bredesen DE, Rao RV. PMID: 18493855; PMCID: PMC2727483.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    67. Programmed cell death mechanisms in neurological disease. Curr Mol Med. 2008 May; 8(3):173-86. Bredesen DE. PMID: 18473818.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    68. Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res. 2008 Aug 22; 191(2):246-55. Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE. PMID: 18485495; PMCID: PMC2757410.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    69. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb; 13(1):1-16. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. PMID: 18334752; PMCID: PMC2818039.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    70. APP-based neuroprotective strategies. Curr Alzheimer Res. 2007 Dec; 4(5):541-3. Bredesen DE, Rabizadeh S. PMID: 18220517.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    71. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985. J Neurosurg. 2007 Dec; 107(6):1253-73; discussion 1251. Levy RM, Bredesen DE, Rosenblum ML. PMID: 18077970.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    72. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. PMID: 18188003; PMCID: PMC2654259.
      View in: PubMed   Mentions: 1191     Fields:    Translation:HumansAnimalsCells
    73. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008 Feb; 104(4):1065-80. Nguyen TV, Galvan V, Huang W, Banwait S, Tang H, Zhang J, Bredesen DE. PMID: 17986220; PMCID: PMC2553705.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    74. Neurogenesis in the adult brain: implications for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2007 Oct; 6(5):303-10. Galvan V, Bredesen DE. PMID: 18045158.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    75. The PDZ domain as a complex adaptive system. PLoS One. 2007 Sep 26; 2(9):e953. Kurakin A, Swistowski A, Wu SC, Bredesen DE. PMID: 17895993; PMCID: PMC1978516.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    76. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J Biol Chem. 2007 Oct 12; 282(41):30150-60. Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. PMID: 17646170.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    77. Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis. 2007 Oct; 28(1):65-75. Galvan V, Banwait S, Spilman P, Gorostiza OF, Peel A, Ataie M, Crippen D, Huang W, Sidhu G, Ichijo H, Bredesen DE. PMID: 17719230; PMCID: PMC2084074.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    78. A novel motif identified in dependence receptors. PLoS One. 2007 May 23; 2(5):e463. del Rio G, Kane DJ, Ball KD, Bredesen DE. PMID: 17520022; PMCID: PMC1866245.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    79. Efficient identification of critical residues based only on protein structure by network analysis. PLoS One. 2007 May 09; 2(5):e421. Cusack MP, Thibert B, Bredesen DE, Del Rio G. PMID: 17502913; PMCID: PMC1855080.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    80. Endoplasmic reticulum stress-induced cell death mediated by the proteasome. Cell Death Differ. 2007 Jun; 14(6):1172-80. Egger L, Madden DT, Rhême C, Rao RV, Bredesen DE. PMID: 17396132; PMCID: PMC2748804.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    81. A calpain-like protease inhibits autophagic cell death. Autophagy. 2007 Sep-Oct; 3(5):519-22. Madden DT, Egger L, Bredesen DE. PMID: 17404499; PMCID: PMC2749617.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    82. Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke. 2007 Feb; 38(2 Suppl):652-60. Bredesen DE. PMID: 17261709; PMCID: PMC1885420.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    83. An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain. J Mol Recognit. 2007 Jan-Feb; 20(1):39-50. Kurakin A, Bredesen DE. PMID: 17094177; PMCID: PMC1847359.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    84. Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med. 2007; 9(3):255-63. Stoka V, Turk V, Bredesen DE. PMID: 17914183; PMCID: PMC2755584.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    85. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci. 2006 Dec 27; 26(52):13428-36. Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. PMID: 17192425; PMCID: PMC6674728.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    86. Cell death in the nervous system. Nature. 2006 Oct 19; 443(7113):796-802. Bredesen DE, Rao RV, Mehlen P. PMID: 17051206; PMCID: PMC3970704.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansAnimalsCells
    87. Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett. 2006 Jun 26; 580(15):3739-45. Stoka V, Turk V, Bredesen DE. PMID: 16777102; PMCID: PMC1847410.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    88. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):7130-5. Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE. PMID: 16641106; PMCID: PMC1459029.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    89. Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). FASEB J. 2006 Jun; 20(8):1254-6. Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH. PMID: 16636103; PMCID: PMC1847355.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    90. Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23. Cell Death Differ. 2006 Mar; 13(3):415-25. Rao RV, Niazi K, Mollahan P, Mao X, Crippen D, Poksay KS, Chen S, Bredesen DE. PMID: 16195741; PMCID: PMC1847409.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    91. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. PMID: 16264422; PMCID: PMC1371037.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    92. Developmental shift in the apostat: comparison of neurones and astrocytes. FEBS Lett. 2005 Nov 07; 579(27):6147-50. Stoka V, Chen SF, Turk V, Bredesen DE. PMID: 16242128; PMCID: PMC1847358.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    93. Improved prediction of critical residues for protein function based on network and phylogenetic analyses. BMC Bioinformatics. 2005 Aug 26; 6:213. Thibert B, Bredesen DE, del Rio G. PMID: 16124876; PMCID: PMC1208857.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    94. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005 Aug; 58(2):277-89. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. PMID: 16049941; PMCID: PMC1847583.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    95. Receptors that mediate cellular dependence. Cell Death Differ. 2005 Aug; 12(8):1031-43. Bredesen DE, Mehlen P, Rabizadeh S. PMID: 16015380.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    96. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol. 2004 Dec; 16(6):653-62. Rao RV, Bredesen DE. PMID: 15530777; PMCID: PMC3970707.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    97. Toward a mechanistic taxonomy of cell death programs. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S3-6. Bredesen DE. PMID: 15665411.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    98. Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ. 2004 Oct; 11(10):1066-75. Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, Nasir J, Bredesen DE. PMID: 15195070.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    99. The non-existent aging program: how does it work? Aging Cell. 2004 Oct; 3(5):255-9. Bredesen DE. PMID: 15379848.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    100. Rebuttal to Austad: 'Is aging programmed? Aging Cell. 2004 Oct; 3(5):261-2. Bredesen DE. PMID: 15379849.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    101. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature. 2004 Sep 02; 431(7004):80-4. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, Mehlen P. PMID: 15343335.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    102. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13363-7. Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, Greenberg DA. PMID: 15340159; PMCID: PMC516572.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    103. Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD. J Neurochem. 2004 Aug; 90(3):549-58. Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M, Nishimoto I. PMID: 15255932.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    104. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004 Apr; 11(4):372-80. Rao RV, Ellerby HM, Bredesen DE. PMID: 14765132.
      View in: PubMed   Mentions: 315     Fields:    Translation:Cells
    105. Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev. 2004 Apr; 84(2):411-30. Bredesen DE, Mehlen P, Rabizadeh S. PMID: 15044679.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    106. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 2004 Apr; 11(4):424-38. Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. PMID: 14713958.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    107. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J Biol Chem. 2004 Apr 23; 279(17):17543-53. Castro-Obregón S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, Bredesen DE. PMID: 14769794.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    108. Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. FEBS Lett. 2004 Jan 30; 558(1-3):57-62. Galvan V, Kurakin AV, Bredesen DE. PMID: 14759516.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    109. siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):283-91. Yokota T, Miyagishi M, Hino T, Matsumura R, Tasinato A, Urushitani M, Rao RV, Takahashi R, Bredesen DE, Taira K, Mizusawa H, Andrea T. PMID: 14715277.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    110. The dependence receptor hypothesis. Apoptosis. 2004 Jan; 9(1):37-49. Mehlen P, Bredesen DE. PMID: 14739597.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    111. Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex. Neuromolecular Med. 2004; 5(3):205-18. Peel AL, Sorscher N, Kim JY, Galvan V, Chen S, Bredesen DE. PMID: 15626821.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    112. Target-assisted iterative screening of phage surface display cDNA libraries. Methods Mol Biol. 2004; 264:47-60. Kurakin A, Wu S, Bredesen DE. PMID: 15020779.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    113. Meeting report: cellular dependence--old concept, new mechanisms. Sci STKE. 2003 Dec 16; 2003(213):pe55. Mehlen P, Bredesen DE. PMID: 14679288.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    114. Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol. 2003 Dec; 54(6):781-9. Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. PMID: 14681887.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    115. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem. 2003 Nov; 87(3):733-41. Lu DC, Soriano S, Bredesen DE, Koo EH. PMID: 14535955.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    116. Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem. 2004 Jan 02; 279(1):177-87. Rao RV, Poksay KS, Castro-Obregon S, Schilling B, Row RH, del Rio G, Gibson BW, Ellerby HM, Bredesen DE. PMID: 14561754.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    117. Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol Dis. 2003 Oct; 14(1):52-62. Peel AL, Bredesen DE. PMID: 13678666.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    118. Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening. J Biol Chem. 2003 Sep 05; 278(36):34102-9. Kurakin AV, Wu S, Bredesen DE. PMID: 12829691.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    119. Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). Cytokine Growth Factor Rev. 2003 Jun-Aug; 14(3-4):225-39. Rabizadeh S, Bredesen DE. PMID: 12787561.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    120. An artificially designed pore-forming protein with anti-tumor effects. J Biol Chem. 2003 Sep 12; 278(37):35311-6. Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. PMID: 12750379.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    121. Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem. 2003 Apr 11; 278(15):13325-32. Galvan V, Logvinova A, Sperandio S, Ichijo H, Bredesen DE. PMID: 12556535.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    122. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci. 2002 Sep 15; 22(18):7862-72. Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. PMID: 12223539; PMCID: PMC6758089.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    123. A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ. 2002 Aug; 9(8):807-17. Castro-Obregón S, Del Rio G, Chen SF, Swanson RA, Frankowski H, Rao RV, Stoka V, Vesce S, Nicholls DG, Bredesen DE. PMID: 12107824.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    124. Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem. 2002 Jul; 82(2):283-94. Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE. PMID: 12124429.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    125. Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins. J Biomol Struct Dyn. 2002 Jun; 19(6):1015-29. Kurakin A, Bredesen D. PMID: 12023804.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    126. Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem. 2002 Jun 14; 277(24):21836-42. Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, del Rio G, Bredesen DE, Ellerby HM. PMID: 11919205.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    127. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002 Mar 13; 514(2-3):122-8. Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE. PMID: 11943137; PMCID: PMC3971841.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    128. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. Neuromolecular Med. 2002; 1(3):153-70. Frankowski H, Castro-Obregon S, del Rio G, Rao RV, Bredesen DE. PMID: 12095158.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    129. Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro. Biochim Biophys Acta. 2001 Dec 19; 1541(3):231-8. Ethell DW, Bossy-Wetzel E, Bredesen DE. PMID: 11755217.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    130. Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radic Biol Med. 2001 Dec 15; 31(12):1550-9. Lee M, Hyun DH, Marshall KA, Ellerby LM, Bredesen DE, Jenner P, Halliwell B. PMID: 11744329.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    131. Mining DNA microarray data using a novel approach based on graph theory. FEBS Lett. 2001 Dec 07; 509(2):230-4. del Rio G, Bartley TF, del-Rio H, Rao R, Jin KL, Greenberg DA, Eshoo M, Bredesen DE. PMID: 11741594.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    132. Neurodegenerative disease and cancer: two sides of a coin? Hosp Pract (1995). 2001 Sep 15; 36(9):39-42, 45. Bredesen DE. PMID: 11565741.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    133. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arthritis Res. 2001; 3(6):357-61. Gerlag DM, Borges E, Tak PP, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E, Firestein GS. PMID: 11714389; PMCID: PMC64846.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    134. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Hum Mol Genet. 2001 Jul 15; 10(15):1531-8. Peel AL, Rao RV, Cottrell BA, Hayden MR, Ellerby LM, Bredesen DE. PMID: 11468270.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    135. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem. 2001 Sep 07; 276(36):33869-74. Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE. PMID: 11448953.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    136. APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide. FEBS Lett. 2001 Apr 13; 494(3):213-9. del Rio G, Castro-Obregon S, Rao R, Ellerby HM, Bredesen DE. PMID: 11311243.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    137. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3416-21. Forcet C, Ye X, Granger L, Corset V, Shin H, Bredesen DE, Mehlen P. PMID: 11248093; PMCID: PMC30668.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    138. An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14376-81. Sperandio S, de Belle I, Bredesen DE. PMID: 11121041; PMCID: PMC18926.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansCells
    139. Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor. J Mol Neurosci. 2000 Dec; 15(3):215-29. Rabizadeh S, Ye X, Sperandio S, Wang JJ, Ellerby HM, Ellerby LM, Giza C, Andrusiak RL, Frankowski H, Yaron Y, Moayeri NN, Rovelli G, Evans CJ, Butcher LL, Nolan GP, Assa-Munt N, Bredesen DE. PMID: 11303785.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    140. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem. 2001 Feb 02; 276(5):3149-57. Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS. PMID: 11073962.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    141. Apoptosis: overview and signal transduction pathways. J Neurotrauma. 2000 Oct; 17(10):801-10. Bredesen DE. PMID: 11063049.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    142. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J. 2000 Aug 01; 19(15):4056-63. Bordeaux MC, Forcet C, Granger L, Corset V, Bidaud C, Billaud M, Bredesen DE, Edery P, Mehlen P. PMID: 10921886; PMCID: PMC306592.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    143. Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression. J Neurochem. 2000 Jul; 75(1):81-90. Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE, Chuang DM. PMID: 10854250.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    144. [Dependence receptors: links between apoptosis, nervous system development and control of tumorigenesis]. Bull Cancer. 2000 Jul; 87(7-8):537-41. Mehlen P, Bredesen DE. PMID: 10969210.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    145. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J Biol Chem. 2000 Jun 30; 275(26):19831-8. Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. PMID: 10770929.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    146. Dimerization-dependent block of the proapoptotic effect of p75(NTR). J Neurosci Res. 2000 Jun 01; 60(5):587-93. Wang JJ, Rabizadeh S, Tasinato A, Sperandio S, Ye X, Green M, Assa-Munt N, Spencer D, Bredesen DE. PMID: 10820429.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    147. Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem. 2000 May 26; 275(21):16127-33. Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. PMID: 10821864.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    148. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000 Apr; 6(4):397-404. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. PMID: 10742146.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    149. The copper transport protein Atox1 promotes neuronal survival. J Biol Chem. 2000 Jan 07; 275(1):580-4. Kelner GS, Lee M, Clark ME, Maciejewski D, McGrath D, Rabizadeh S, Lyons T, Bredesen D, Jenner P, Maki RA. PMID: 10617654.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    150. Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis. Methods Enzymol. 2000; 322:413-21. Ellerby LM, Bredesen DE. PMID: 10914037.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    151. Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF. Cell Death Differ. 1999 Dec; 6(12):1222-7. Rabizadeh S, Rabizadeh S, Ye X, Wang JJ, Bredesen DE. PMID: 10637439.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    152. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. FEBS Lett. 1999 Oct 29; 460(2):191-8. Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA. PMID: 10544233.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    153. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem. 1999 Oct 15; 274(42):30202-8. Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. PMID: 10514511.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    154. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med. 1999 Sep; 5(9):1032-8. Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. PMID: 10470080.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    155. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5752-7. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. PMID: 10318956; PMCID: PMC21932.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    156. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem. 1999 Mar 26; 274(13):8730-6. Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. PMID: 10085113.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    157. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. J Neurosci. 1999 Jan 15; 19(2):637-43. Hong CS, Caromile L, Nomata Y, Mori H, Bredesen DE, Koo EH. PMID: 9880584; PMCID: PMC6782201.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    158. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem. 1999 Jan; 72(1):185-95. Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. PMID: 9886069.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    159. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature. 1998 Oct 22; 395(6704):801-4. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE. PMID: 9796814.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    160. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90. Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. PMID: 9765224.
      View in: PubMed   Mentions: 174     Fields:    Translation:Cells
    161. Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2. Arch Biochem Biophys. 1998 Aug 01; 356(1):41-5. Spear N, Estévez AG, Johnson GV, Bredesen DE, Thompson JA, Beckman JS. PMID: 9681989.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    162. Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores. J Neurochem. 1998 Jun; 70(6):2305-14. Wei H, Wei W, Bredesen DE, Perry DC. PMID: 9603195.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    163. p75NTR and the concept of cellular dependence: seeing how the other half die. Cell Death Differ. 1998 May; 5(5):365-71. Bredesen DE, Ye X, Tasinato A, Sperandio S, Wang JJ, Assa-Munt N, Rabizadeh S. PMID: 10200485.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    164. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):4997-5002. Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. PMID: 9560217; PMCID: PMC20202.
      View in: PubMed   Mentions: 358     Fields:    Translation:HumansAnimalsCells
    165. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem. 1998 Apr 10; 273(15):9158-67. Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. PMID: 9535906.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    166. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates. Nat Genet. 1998 Feb; 18(2):150-4. Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. PMID: 9462744.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    167. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide. J Neurochem. 1998 Jan; 70(1):31-9. Bruce-Keller AJ, Begley JG, Fu W, Butterfield DA, Bredesen DE, Hutchins JB, Hensley K, Mattson MP. PMID: 9422344.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    168. Expression of CD40 induces neural apoptosis. J Neurosci Res. 1997 Nov 01; 50(3):383-90. Ruan Y, Rabizadeh S, Camerini D, Bredesen DE. PMID: 9364323.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    169. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci. 1997 Oct 15; 17(20):7594-605. Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. PMID: 9315882; PMCID: PMC6793892.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    170. A cytoplasmic peptide of the neurotrophin receptor p75NTR: induction of apoptosis and NMR determined helical conformation. FEBS Lett. 1997 Sep 29; 415(2):145-54. Hileman MR, Chapman BS, Rabizadeh S, Krishnan VV, Bredesen D, Assa-Munt N, Plesniak LA. PMID: 9350985.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    171. Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci. 1997 Aug 15; 17(16):6165-78. Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE. PMID: 9236228; PMCID: PMC3913837.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    172. Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis? Ann Neurol. 1997 Aug; 42(2):135-7. Bredesen DE, Ellerby LM, Hart PJ, Wiedau-Pazos M, Valentine JS. PMID: 9266721.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    173. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci. 1997 Jul 01; 17(13):5089-100. Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP. PMID: 9185546; PMCID: PMC6573293.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    174. p75NTR and apoptosis: Trk-dependent and Trk-independent effects. Trends Neurosci. 1997 Jul; 20(7):287-90. Bredesen DE, Rabizadeh S. PMID: 9223218.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    175. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol. 1997 Jun 30; 137(7):1581-8. Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. PMID: 9199172; PMCID: PMC2137818.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    176. Activation of CPP32 during apoptosis of neurons and astrocytes. J Neurosci Res. 1997 Apr 15; 48(2):168-80. Keane RW, Srinivasan A, Foster LM, Testa MP, Ord T, Nonner D, Wang HG, Reed JC, Bredesen DE, Kayalar C. PMID: 9130145.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    177. Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12240-4. Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Café C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS. PMID: 8901564; PMCID: PMC37974.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    178. Cell death mechanisms in ALS. Neurology. 1996 Oct; 47(4 Suppl 2):S36-8; discussion S38-9. Bredesen DE, Wiedau-Pazos M, Goto JJ, Rabizadeh S, Roe JA, Gralla EB, Ellerby LM, Valentine JS. PMID: 8858049.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    179. Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis. J Neurosci. 1996 Sep 15; 16(18):5654-60. Srinivasan A, Foster LM, Testa MP, Ord T, Keane RW, Bredesen DE, Kayalar C. PMID: 8795621; PMCID: PMC6578959.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    180. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9893-8. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. PMID: 8790427; PMCID: PMC38525.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    181. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem. 1996 Sep; 67(3):1259-67. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE. PMID: 8752134.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    182. Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2234-8. Kayalar C, Ord T, Testa MP, Zhong LT, Bredesen DE. PMID: 8700913; PMCID: PMC39941.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    183. Expression of bcl-2 inhibits cellular radical generation. Free Radic Res. 1996 Mar; 24(3):205-12. Wiedau-Pazos M, Trudell JR, Altenbach C, Kane DJ, Hubbell WL, Bredesen DE. PMID: 8728122.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    184. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science. 1996 Jan 26; 271(5248):515-8. Wiedau-Pazos M, Goto JJ, Rabizadeh S, Gralla EB, Roe JA, Lee MK, Valentine JS, Bredesen DE. PMID: 8560268.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    185. Genetic control of neural cell apoptosis. Perspect Dev Neurobiol. 1996; 3(2):101-9. Bredesen DE. PMID: 8826528.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    186. Cellular resistance to methylmercury. Neurotoxicology. 1996; 17(1):27-36. Sarafian TA, Bredesen DE, Verity MA. PMID: 8784816.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    187. Neural apoptosis. Ann Neurol. 1995 Dec; 38(6):839-51. Bredesen DE. PMID: 8526456.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    188. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem. 1995 Dec; 65(6):2432-40. Myers KM, Fiskum G, Liu Y, Simmens SJ, Bredesen DE, Murphy AN. PMID: 7595537.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    189. Role of reactive oxygen species (ROS) in neuronal degeneration. Modulation by protooncogene expression. Ann N Y Acad Sci. 1995 Sep 15; 765:340. Verity MA, Bredesen DE, Sarafian T. PMID: 7486641.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    190. Apoptotic cell death of a temperature-sensitive central neuronal cell line. Brain Res. 1995 Jun 26; 684(1):79-86. Hisanaga K, Kure S, Bredesen DE, Ikeda Y, Kohsaka S, Sharp FR. PMID: 7583207.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    191. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):3024-8. Rabizadeh S, Gralla EB, Borchelt DR, Gwinn R, Valentine JS, Sisodia S, Wong P, Lee M, Hahn H, Bredesen DE. PMID: 7708768; PMCID: PMC42351.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    192. Expression of bcl-2 inhibits necrotic neural cell death. J Neurosci Res. 1995 Feb 01; 40(2):269-75. Kane DJ, Ord T, Anton R, Bredesen DE. PMID: 7745620.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    193. Neural transplantation of cells expressing the anti-apoptotic gene bcl-2. Cell Transplant. 1995 Jan-Feb; 4(1):49-54. Anton R, Kordower JH, Kane DJ, Markham CH, Bredesen DE. PMID: 7728333.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    194. bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line. Toxicol Lett. 1994 Nov; 74(2):149-55. Sarafian TA, Vartavarian L, Kane DJ, Bredesen DE, Verity MA. PMID: 7940596.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    195. Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10703-6. Rabizadeh S, Bitler CM, Butcher LL, Bredesen DE. PMID: 7938014; PMCID: PMC45090.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    196. Is apoptosis mediated by reactive oxygen species? Free Radic Res. 1994 Jul; 21(1):1-8. Sarafian TA, Bredesen DE. PMID: 7951907.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    197. Is p75NGFR involved in developmental neural cell death? Dev Neurosci. 1994; 16(3-4):207-11. Rabizadeh S, Bredesen DE. PMID: 7535682.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    198. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J Neurochem. 1993 Dec; 61(6):2318-21. Rabizadeh S, LaCount DJ, Friesen PD, Bredesen DE. PMID: 8245984.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    199. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 1993 Nov 19; 262(5137):1274-7. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. PMID: 8235659.
      View in: PubMed   Mentions: 267     Fields:    Translation:AnimalsCells
    200. Neurological reactions in HIV-infected patients treated with trichosanthin. Neuropathol Appl Neurobiol. 1993 Oct; 19(5):402-5. Garcia PA, Bredesen DE, Vinters HV, Graefin von Einsiedel R, Williams RL, Kahn JO, Byers VS, Levin AS, Waites LA, Messing RO. PMID: 8278023.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    201. BCL-2 blocks glutamate toxicity in neural cell lines. Brain Res Mol Brain Res. 1993 Sep; 19(4):353-5. Zhong LT, Kane DJ, Bredesen DE. PMID: 7901730.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    202. Induction of apoptosis by the low-affinity NGF receptor. Science. 1993 Jul 16; 261(5119):345-8. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE. PMID: 8332899.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    203. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4533-7. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE. PMID: 8506295; PMCID: PMC46546.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    204. The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J Neurochem. 1993 Mar; 60(3):1183-6. Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH, Bredesen DE. PMID: 8436969.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    205. Expression of myelin protein genes and other myelin components in an oligodendrocytic cell line conditionally immortalized with a temperature-sensitive retrovirus. J Neurochem. 1993 Feb; 60(2):577-87. Verity AN, Bredesen D, Vonderscher C, Handley VW, Campagnoni AT. PMID: 7678286.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    206. Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation. Dev Neurosci. 1993; 15(2):100-9. Foster LM, Phan T, Verity AN, Bredesen D, Campagnoni AT. PMID: 8168435.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    207. Increasing the proliferative capacity of muscular dystrophy myoblasts. Muscle Nerve. 1992 Aug; 15(8):941-8. Yang J, Seelig M, Rayner S, Bredesen DE. PMID: 1495511.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    208. Preliminary characterization of long-term reaggregating cultures of trisomy 16 central nervous system. Prog Clin Biol Res. 1992; 379:259-70. Bredesen DE, Kane DJ, Holtzman DM, Epstein CJ. PMID: 1409749.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    209. The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study. AIDS. 1990 Dec; 4(12):1197-204. Kahn JO, Kaplan LD, Gambertoglio JG, Bredesen D, Arri CJ, Turin L, Kibort T, Williams RL, Lifson JD, Volberding PA. PMID: 2088398.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsCTClinical Trials
    210. Neural transplantation using temperature-sensitive immortalized neural cells: a preliminary report. Ann Neurol. 1990 Feb; 27(2):205-7. Bredesen DE, Hisanaga K, Sharp FR. PMID: 2156481.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    211. Neurologic complications of HIV infection. Am Fam Physician. 1990 Feb; 41(2):517-36. Levy RM, Bredesen DE, Rosenblum ML. PMID: 2154083.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    212. The efficacy and clinical impact of brain imaging in neurologically symptomatic AIDS patients: a prospective CT/MRI study. J Acquir Immune Defic Syndr (1988). 1990; 3(5):461-71. Levy RM, Mills CM, Posin JP, Moore SG, Rosenblum ML, Bredesen DE. PMID: 2324943.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    213. The acquired immunodeficiency syndrome (AIDS) dementia complex. Ann Intern Med. 1989 Sep 01; 111(5):400-10. Ho DD, Bredesen DE, Vinters HV, Daar ES. PMID: 2548429.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    214. Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome. Am J Med. 1989 May; 86(5):528-32. Engstrom JW, Lowenstein DH, Bredesen DE. PMID: 2712060.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    215. Controversies in HIV-related central nervous system disease: neuropsychological aspects of HIV-1 infection. AIDS Clin Rev. 1989; 151-91. Levy RM, Bredesen DE. PMID: 2488690.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    216. Central nervous system disorders in AIDS. Immunol Ser. 1989; 44:371-401. Levy RM, Bredesen DE, Rosenblum ML, Davis RL. PMID: 2489119.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    217. The neurology of human immunodeficiency virus infection. Q J Med. 1988 Sep; 68(257):665-77. Bredesen DE, Levy RM, Rosenblum ML. PMID: 2855754.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    218. Prion protein gene expression in cultured cells. Protein Eng. 1988 Apr; 2(1):69-76. Scott MR, Butler DA, Bredesen DE, Wälchli M, Hsiao KK, Prusiner SB. PMID: 2908139.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    219. Central nervous system dysfunction in acquired immunodeficiency syndrome. J Acquir Immune Defic Syndr (1988). 1988; 1(1):41-64. Levy RM, Bredesen DE. PMID: 3063805.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    220. Primary central nervous system lymphomas in patients with AIDS. Ann Neurol. 1988; 23 Suppl:S13-6. Rosenblum ML, Levy RM, Bredesen DE, So YT, Wara W, Ziegler JL. PMID: 2894803.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    221. Neurosurgical implications of the acquired immunodeficiency syndrome (AIDS). Clin Neurosurg. 1988; 34:419-45. Rosenblum ML, Levy RM, Bredesen DE. PMID: 3288404.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    222. Opportunistic central nervous system pathology in patients with AIDS. Ann Neurol. 1988; 23 Suppl:S7-12. Levy RM, Bredesen DE, Rosenblum ML. PMID: 2831804.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    223. Recovery of herpesviruses from cerebrospinal fluid of immunodeficient homosexual men. Ann Neurol. 1985 Nov; 18(5):611-4. Dix RD, Bredesen DE, Erlich KS, Mills J. PMID: 3000285.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    224. Sensory neuropathy with low-dose pyridoxine. Neurology. 1985 Oct; 35(10):1466-8. Parry GJ, Bredesen DE. PMID: 2993949.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    225. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg. 1985 Apr; 62(4):475-95. Levy RM, Bredesen DE, Rosenblum ML. PMID: 2983051.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansCells
    226. Neurology: neurologic manifestations of AIDS. West J Med. 1985 Jan; 142(1):84. Bredesen DE. PMID: 18749682; PMCID: PMC1305941.
      View in: PubMed   Mentions:    Fields:    
    227. Periodic confusion caused by congenital extrahepatic portacaval shunt. Neurology. 1984 May; 34(5):666-9. Raskin NH, Bredesen D, Ehrenfeld WK, Kerlan RK. PMID: 6538657.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    228. Failure of naloxone to reverse vascular neurologic deficits. Neurology. 1983 Nov; 33(11):1517-8. Cutler JR, Bredesen DE, Edwards R, Simon RP. PMID: 6685246.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    229. Neoplasms of the anterior pituitary. Neurosurgery. 1978 Jul-Aug; 3(1):96-104. McCarty KS, Bredesen DE, Vogel FS. PMID: 210418.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
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