Dale Eric Bredesen

Title(s)Professor-in-Residence, Molecular and Medical Pharmacology
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    Collapse Research 
    Collapse Research Activities and Funding
    APP signaling network
    NIH R21AG036975Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Novel Prionic Mechanism Underlying Alzheimer?s Disease
    NIH R01AG034427Jul 15, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Development and Improvement of an Animal Resource Core
    NIH G20RR022770Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator
    Basic Mechanisms in Aging and Age Related Disease
    NIH P30AG025708Jul 1, 2005 - Jun 30, 2011
    Role: Co-Principal Investigator
    Buck Institute--Pharmacology of Lifespan Extension
    NIH R13AG026961Jun 1, 2005 - May 31, 2006
    Role: Principal Investigator
    Center for Integrative Studies of Aging
    NIH C06RR020660Sep 30, 2004 - Jun 30, 2009
    Role: Principal Investigator
    Mechanism of apoptosis induction by the receptor DCC
    NIH R01NS045093Feb 1, 2003 - Jan 31, 2008
    Role: Principal Investigator
    Training in Age-Related Disease and Aging Research
    NIH T32AG020495May 1, 2002 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Alzheimer's Disease Research Center
    NIH P50AG016570Apr 5, 1999 - Mar 31, 2016
    Role: Principal Investigator
    Apoptosis: Basic Mechanisms and Disease Relevance
    NIH T32AG000252Jun 15, 1997 - Apr 30, 2004
    Role: Co-Principal Investigator
    NIH R01NS035155Jun 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Novel apoptotic pathway activated by misfolded proteins
    NIH R01NS033376Jan 1, 1997 - Jun 30, 2008
    Role: Principal Investigator
    Mechanism of inhibition of neurodegeneration and aging
    NIH R01AG012282May 1, 1994 - Mar 31, 2008
    Role: Principal Investigator
    NIH R01AG010671Sep 29, 1991 - Jun 30, 1994
    Role: Principal Investigator
    NIH R29NS027812Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    NIH F32NS008100Feb 28, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review. Int J Mol Sci. 2023 Jan 14; 24(2). Rao RV, Subramaniam KG, Gregory J, Bredesen AL, Coward C, Okada S, Kelly L, Bredesen DE. PMID: 36675177.
      View in: PubMed   Mentions: 1     Fields:    
    2. Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? Am J Clin Nutr. 2023 Mar; 117(3):455-466. Johnson RJ, Tolan DR, Bredesen D, Nagel M, Sánchez-Lozada LG, Fini M, Burtis S, Lanaspa MA, Perlmutter D. PMID: 36774227.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project. J Alzheimers Dis. 2022; 88(4):1411-1421. Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE. PMID: 35811518; PMCID: PMC9484109.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline. Biomedicines. 2021 Sep 29; 9(10). Rao RV, Kumar S, Gregory J, Coward C, Okada S, Lipa W, Kelly L, Bredesen DE. PMID: 34680464; PMCID: PMC8533598.
      View in: PubMed   Mentions: 3  
    5. Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease. J Alzheimers Dis Parkinsonism. 2021; 11(Suppl 5). Ross MK, Raji C, Lokken KL, Bredesen DE, Roach JC, Funk CC, Price N, Rappaport N, Hood L, Heath JR. PMID: 35237464; PMCID: PMC8887953.
      View in: PubMed   Mentions:
    6. Neuroprotective Herbs for the Management of Alzheimer's Disease. Biomolecules. 2021 04 08; 11(4). Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. PMID: 33917843; PMCID: PMC8068256.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    7. Alzheimer's disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics. Aging (Albany NY). 2020 Sep 21; 12(18):17815-17844. Kurakin A, Bredesen DE. PMID: 32957083; PMCID: PMC7585078.
      View in: PubMed   Mentions: 3     Fields:    
    8. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 12 04; 8(1):17574. Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, Cole G, LaDu MJ, Jung ME, Bredesen DE, John V. PMID: 30514854; PMCID: PMC6279743.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    9. Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease. Mol Neurobiol. 2018 Jun; 55(6):5243-5254. Theendakara V, Peters-Libeu CA, Bredesen DE, Rao RV. PMID: 28879423.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    10. Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease. Mol Cell Neurosci. 2017 09; 83:83-91. Theendakara V, Bredesen DE, Rao RV. PMID: 28720530.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    11. Ayurvedic Profiling of Alzheimer's Disease. Altern Ther Health Med. 2017 May; 23(3):46-50. Bredesen DE, Rao RV. PMID: 28236613.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017; 8:46. Poksay KS, Sheffler DJ, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. PMID: 28261092; PMCID: PMC5309220.
      View in: PubMed   Mentions: 1  
    13. Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation. FASEB J. 2017 01; 31(1):148-160. Famenini S, Rigali EA, Olivera-Perez HM, Dang J, Chang MT, Halder R, Rao RV, Pellegrini M, Porter V, Bredesen D, Fiala M. PMID: 27677546; PMCID: PMC5161513.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    14. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 06; 8(6):1250-8. Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. PMID: 27294343; PMCID: PMC4931830.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    15. Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 03 08; 52(1):223-42. Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. PMID: 27060954.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic. Aging (Albany NY). 2016 Feb; 8(2):304-13. Bredesen DE. PMID: 26870879; PMCID: PMC4789584.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    17. Direct Transcriptional Effects of Apolipoprotein E. J Neurosci. 2016 Jan 20; 36(3):685-700. Theendakara V, Peters-Libeu CA, Spilman P, Poksay KS, Bredesen DE, Rao RV. PMID: 26791201; PMCID: PMC4719010.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    18. Metabolic profiling distinguishes three subtypes of Alzheimer's disease. Aging (Albany NY). 2015 Aug; 7(8):595-600. Bredesen DE. PMID: 26343025; PMCID: PMC4586104.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    19. Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget. 2015 Jun 10; 6(16):14092-122. Kurakin A, Bredesen DE. PMID: 26041885; PMCID: PMC4546454.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline. AJNR Am J Neuroradiol. 2015 Oct; 36(10):1803-9. Raji CA, Eyre H, Wei SH, Bredesen DE, Moylan S, Law M, Small G, Thompson PM, Friedlander RM, Silverman DH, Baune BT, Hoang TA, Salamon N, Toga AW, Vernooij MW. PMID: 26045577; PMCID: PMC4600413.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul; 29(7):2681-9. Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. PMID: 25805829.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    22. Correction to hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2015 Feb 26; 58(4):2045. Ellerby HM, Bredesen DE, Fujimura S, John V. PMID: 25668572.
      View in: PubMed   Mentions:    Fields:    
    23. Alzheimer's Model Develops Early ADHD Syndrome. J Neurol Neurophysiol. 2015; 6(6):1-6. Zhang Q, Du G, John V, Kapahi P, Bredesen DE. PMID: 26753104; PMCID: PMC4704098.
      View in: PubMed   Mentions: 7  
    24. sAβPPα is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis. 2015; 47(3):545-55. Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. PMID: 26401691.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    25. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan; 22(1):58-73. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. PMID: 25236395; PMCID: PMC4262782.
      View in: PubMed   Mentions: 378     Fields:    Translation:HumansAnimalsCells
    26. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep; 6(9):707-17. Bredesen DE. PMID: 25324467; PMCID: PMC4221920.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCTClinical Trials
    27. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617. Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. PMID: 24531152; PMCID: PMC4091737.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014 Mar 10; 1551:25-44. Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. PMID: 24389031; PMCID: PMC4001856.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8. Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. PMID: 24145446; PMCID: PMC3831497.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    30. Next generation therapeutics for Alzheimer's disease. EMBO Mol Med. 2013 Jun; 5(6):795-8. Bredesen DE, John V. PMID: 23703924; PMCID: PMC3779441.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    31. AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. J Alzheimers Dis. 2013; 37(2):343-55. Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. PMID: 23948888; PMCID: PMC3971881.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21; 32(47):16775-84. Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. PMID: 23175831; PMCID: PMC3736741.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    33. mCiRNA-synaptic crystal ball? Aging (Albany NY). 2012 Nov; 4(11):732-3. Bredesen D. PMID: 23241907; PMCID: PMC3560433.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. The small co-chaperone p23 overexpressing transgenic mouse. J Neurosci Methods. 2013 Jan 30; 212(2):190-4. Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV. PMID: 23022695; PMCID: PMC3562756.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    35. Moonlighting peptides with emerging function. PLoS One. 2012; 7(7):e40125. Rodríguez Plaza JG, Villalón Rojas A, Herrera S, Garza-Ramos G, Torres Larios A, Amero C, Zarraga Granados G, Gutiérrez Aguilar M, Lara Ortiz MT, Polanco Gonzalez C, Uribe Carvajal S, Coria R, Peña Díaz A, Bredesen DE, Castro-Obregon S, del Rio G. PMID: 22808104; PMCID: PMC3396687.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther. 2012 Jun 29; 4(3):22. Rao RV, Descamps O, John V, Bredesen DE. PMID: 22747839; PMCID: PMC3506936.
      View in: PubMed   Mentions: 36     Fields:    
    37. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012; 7(6):e40027. Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE. PMID: 22768208; PMCID: PMC3386930.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis? Antioxid Redox Signal. 2012 Dec 01; 17(11):1507-14. Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA. PMID: 22500616; PMCID: PMC3448937.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    39. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One. 2011; 6(12):e28530. Madden DT, Davila-Kruger D, Melov S, Bredesen DE. PMID: 22174832; PMCID: PMC3235131.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    40. The small chaperone protein p23 and its cleaved product p19 in cellular stress. J Mol Neurosci. 2012 Feb; 46(2):303-14. Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV. PMID: 21691801; PMCID: PMC3246043.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    41. Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging Dis. 2011 Feb; 2(1):18-29. Zhang J, Rao RV, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE, Galvan V. PMID: 21874159; PMCID: PMC3160738.
      View in: PubMed   Mentions: 2  
    42. Dependence receptors: from basic research to drug development. Sci Signal. 2011 Jan 25; 4(157):mr2. Mehlen P, Bredesen DE. PMID: 21266712.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    43. Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration. J Mol Neurosci. 2011 Jun; 44(2):91-102. Poksay KS, Madden DT, Peter AK, Niazi K, Banwait S, Crippen D, Bredesen DE, Rao RV. PMID: 21249466; PMCID: PMC3084943.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Neuroscience. 2011 Mar 17; 177:207-22. Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA. PMID: 21223993; PMCID: PMC3058851.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    45. Signaling via amyloid precursor-like proteins APLP1 and APLP2. J Alzheimers Dis. 2011; 23(4):689-99. Orcholski ME, Zhang Q, Bredesen DE. PMID: 21178287.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Induction of the C-terminal proteolytic cleavage of AβPP by statins. J Alzheimers Dis. 2011; 25(1):51-7. Descamps O, Zhang Q, John V, Bredesen DE. PMID: 21422530.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    47. Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimers Dis. 2011; 25(3):547-66. Libeu CP, Poksay KS, John V, Bredesen DE. PMID: 21471643; PMCID: PMC4001850.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    48. Identification of new modulators and protein alterations in non-apoptotic programmed cell death. J Cell Biochem. 2010 Dec 15; 111(6):1401-12. Sperandio S, Poksay KS, Schilling B, Crippen D, Gibson BW, Bredesen DE. PMID: 20830744; PMCID: PMC5668132.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    49. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 01; 5(4):e9979. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. PMID: 20376313; PMCID: PMC2848616.
      View in: PubMed   Mentions: 520     Fields:    Translation:AnimalsCells
    50. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci. 2010 Jan 06; 30(1):372-81. Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. PMID: 20053918; PMCID: PMC3064502.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    51. Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis. 2010; 22(1):57-63. Bredesen DE, John V, Galvan V. PMID: 20847422; PMCID: PMC3968071.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    52. Novel mediators of amyloid precursor protein signaling. J Neurosci. 2009 Dec 16; 29(50):15703-12. Swistowski A, Zhang Q, Orcholski ME, Crippen D, Vitelli C, Kurakin A, Bredesen DE. PMID: 20016085; PMCID: PMC2823633.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    53. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free Radic Biol Med. 2010 Jan 01; 48(1):136-44. Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. PMID: 19854267; PMCID: PMC2818480.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    54. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 2011 Sep; 32(9):1725-9. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. PMID: 19828212; PMCID: PMC2889215.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    55. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res. 2010 Jan 20; 206(2):202-7. Zhang J, Gorostiza OF, Tang H, Bredesen DE, Galvan V. PMID: 19751769; PMCID: PMC2783897.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    56. Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):450-5. Park SA, Shaked GM, Bredesen DE, Koo EH. PMID: 19679105; PMCID: PMC2838490.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    57. Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener. 2009 Jun 26; 4:27. Bredesen DE. PMID: 19558683; PMCID: PMC2709109.
      View in: PubMed   Mentions: 41     Fields:    
    58. Interfering with multimerization of netrin-1 receptors triggers tumor cell death. Cell Death Differ. 2009 Oct; 16(10):1344-51. Mille F, Llambi F, Guix C, Delloye-Bourgeois C, Guenebeaud C, Castro-Obregon S, Bredesen DE, Thibert C, Mehlen P. PMID: 19543238; PMCID: PMC2841642.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
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