Loading...

Dale Eric Bredesen

Title(s)Professor-in-Residence, Molecular and Medical Pharmacology
SchoolMedicine
Phone310-794-3659
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    APP signaling network
    NIH/NIA R21AG036975Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Novel Prionic Mechanism Underlying Alzheimer?s Disease
    NIH/NIA R01AG034427Jul 15, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Development and Improvement of an Animal Resource Core
    NIH/NCRR G20RR022770Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator
    Basic Mechanisms in Aging and Age Related Disease
    NIH/NIA P30AG025708Jul 1, 2005 - Jun 30, 2011
    Role: Co-Principal Investigator
    Buck Institute--Pharmacology of Lifespan Extension
    NIH/NIA R13AG026961Jun 1, 2005 - May 31, 2006
    Role: Principal Investigator
    Center for Integrative Studies of Aging
    NIH/NCRR C06RR020660Sep 30, 2004 - Jun 30, 2009
    Role: Principal Investigator
    Mechanism of apoptosis induction by the receptor DCC
    NIH/NINDS R01NS045093Feb 1, 2003 - Jan 31, 2008
    Role: Principal Investigator
    Training in Age-Related Disease and Aging Research
    NIH/NIA T32AG020495May 1, 2002 - Apr 30, 2008
    Role: Principal Investigator
    UCLA Alzheimer's Disease Research Center
    NIH/NIA P50AG016570Apr 5, 1999 - Mar 31, 2015
    Role: Principal Investigator
    Apoptosis: Basic Mechanisms and Disease Relevance
    NIH/NIA T32AG000252Jun 15, 1997 - Apr 30, 2004
    Role: Co-Principal Investigator
    FAMILIAL ALS--MECHANISM OF INITIATION
    NIH/NINDS R01NS035155Jun 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Novel apoptotic pathway activated by misfolded proteins
    NIH/NINDS R01NS033376Jan 1, 1997 - Jun 30, 2008
    Role: Principal Investigator
    Mechanism of inhibition of neurodegeneration and aging
    NIH/NIA R01AG012282May 1, 1994 - Mar 31, 2008
    Role: Principal Investigator
    A GENETICALLY TRACTABLE IN VITRO MODEL OF AD
    NIH/NIA R01AG010671Sep 29, 1991 - Jun 30, 1994
    Role: Principal Investigator
    MOLECULAR EFFECTS OF SPECIFIC HIV PROTEINS ON THE CNS
    NIH/NINDS R29NS027812Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    ANALYSIS OF THE PEP GENE IN NZW AND I/LNJ
    NIH/NINDS F32NS008100Feb 28, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, Cole G, LaDu MJ, Jung ME, Bredesen DE, John V. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 12 04; 8(1):17574. PMID: 30514854.
      View in: PubMed
    2. Theendakara V, Peters-Libeu CA, Bredesen DE, Rao RV. Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease. Mol Neurobiol. 2018 Jun; 55(6):5243-5254. PMID: 28879423.
      View in: PubMed
    3. Theendakara V, Bredesen DE, Rao RV. Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease. Mol Cell Neurosci. 2017 09; 83:83-91. PMID: 28720530.
      View in: PubMed
    4. Bredesen DE, Rao RV. Ayurvedic Profiling of Alzheimer's Disease. Altern Ther Health Med. 2017 May; 23(3):46-50. PMID: 28236613.
      View in: PubMed
    5. Poksay KS, Sheffler DJ, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017; 8:46. PMID: 28261092.
      View in: PubMed
    6. Famenini S, Rigali EA, Olivera-Perez HM, Dang J, Chang MT, Halder R, Rao RV, Pellegrini M, Porter V, Bredesen D, Fiala M. Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ?-3 supplementation. FASEB J. 2017 01; 31(1):148-160. PMID: 27677546.
      View in: PubMed
    7. Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 06; 8(6):1250-8. PMID: 27294343.
      View in: PubMed
    8. Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. Netrin-1 Interrupts Amyloid-ß Amplification, Increases sAßPPa in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 03 08; 52(1):223-42. PMID: 27060954.
      View in: PubMed
    9. Bredesen DE. Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic. Aging (Albany NY). 2016 Feb; 8(2):304-13. PMID: 26870879.
      View in: PubMed
    10. Theendakara V, Peters-Libeu CA, Spilman P, Poksay KS, Bredesen DE, Rao RV. Direct Transcriptional Effects of Apolipoprotein E. J Neurosci. 2016 Jan 20; 36(3):685-700. PMID: 26791201.
      View in: PubMed
    11. Bredesen DE. Metabolic profiling distinguishes three subtypes of Alzheimer's disease. Aging (Albany NY). 2015 Aug; 7(8):595-600. PMID: 26343025.
      View in: PubMed
    12. Kurakin A, Bredesen DE. Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget. 2015 Jun 10; 6(16):14092-122. PMID: 26041885.
      View in: PubMed
    13. Raji CA, Eyre H, Wei SH, Bredesen DE, Moylan S, Law M, Small G, Thompson PM, Friedlander RM, Silverman DH, Baune BT, Hoang TA, Salamon N, Toga AW, Vernooij MW. Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline. AJNR Am J Neuroradiol. 2015 Oct; 36(10):1803-9. PMID: 26045577.
      View in: PubMed
    14. Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ?-3 Supplementation increases amyloid-ß phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul; 29(7):2681-9. PMID: 25805829.
      View in: PubMed
    15. Ellerby HM, Bredesen DE, Fujimura S, John V. Correction to hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2015 Feb 26; 58(4):2045. PMID: 25668572.
      View in: PubMed
    16. Zhang Q, Du G, John V, Kapahi P, Bredesen DE. Alzheimer's Model Develops Early ADHD Syndrome. J Neurol Neurophysiol. 2015; 6(6):1-6. PMID: 26753104.
      View in: PubMed
    17. Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. sAßPPa is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis. 2015; 47(3):545-55. PMID: 26401691.
      View in: PubMed
    18. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan; 22(1):58-73. PMID: 25236395.
      View in: PubMed
    19. Bredesen DE. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep; 6(9):707-17. PMID: 25324467.
      View in: PubMed
    20. Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617. PMID: 24531152.
      View in: PubMed
    21. Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014 Mar 10; 1551:25-44. PMID: 24389031.
      View in: PubMed
    22. Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8. PMID: 24145446.
      View in: PubMed
    23. Bredesen DE, John V. Next generation therapeutics for Alzheimer's disease. EMBO Mol Med. 2013 Jun; 5(6):795-8. PMID: 23703924.
      View in: PubMed
    24. Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. AßPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. J Alzheimers Dis. 2013; 37(2):343-55. PMID: 23948888.
      View in: PubMed
    25. Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21; 32(47):16775-84. PMID: 23175831.
      View in: PubMed
    26. Bredesen D. mCiRNA-synaptic crystal ball? Aging (Albany NY). 2012 Nov; 4(11):732-3. PMID: 23241907.
      View in: PubMed
    27. Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV. The small co-chaperone p23 overexpressing transgenic mouse. J Neurosci Methods. 2013 Jan 30; 212(2):190-4. PMID: 23022695.
      View in: PubMed
    28. Rodríguez Plaza JG, Villalón Rojas A, Herrera S, Garza-Ramos G, Torres Larios A, Amero C, Zarraga Granados G, Gutiérrez Aguilar M, Lara Ortiz MT, Polanco Gonzalez C, Uribe Carvajal S, Coria R, Peña Díaz A, Bredesen DE, Castro-Obregon S, del Rio G. Moonlighting peptides with emerging function. PLoS One. 2012; 7(7):e40125. PMID: 22808104.
      View in: PubMed
    29. Rao RV, Descamps O, John V, Bredesen DE. Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther. 2012 Jun 29; 4(3):22. PMID: 22747839.
      View in: PubMed
    30. Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012; 7(6):e40027. PMID: 22768208.
      View in: PubMed
    31. Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis? Antioxid Redox Signal. 2012 Dec 01; 17(11):1507-14. PMID: 22500616.
      View in: PubMed
    32. Madden DT, Davila-Kruger D, Melov S, Bredesen DE. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One. 2011; 6(12):e28530. PMID: 22174832.
      View in: PubMed
    33. Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV. The small chaperone protein p23 and its cleaved product p19 in cellular stress. J Mol Neurosci. 2012 Feb; 46(2):303-14. PMID: 21691801.
      View in: PubMed
    34. Zhang J, Rao RV, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE, Galvan V. Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging Dis. 2011 Feb; 2(1):18-29. PMID: 21874159.
      View in: PubMed
    35. Mehlen P, Bredesen DE. Dependence receptors: from basic research to drug development. Sci Signal. 2011 Jan 25; 4(157):mr2. PMID: 21266712.
      View in: PubMed
    36. Poksay KS, Madden DT, Peter AK, Niazi K, Banwait S, Crippen D, Bredesen DE, Rao RV. Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration. J Mol Neurosci. 2011 Jun; 44(2):91-102. PMID: 21249466.
      View in: PubMed
    37. Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-ß peptide of amyloid precursor protein. Neuroscience. 2011 Mar 17; 177:207-22. PMID: 21223993.
      View in: PubMed
    38. Orcholski ME, Zhang Q, Bredesen DE. Signaling via amyloid precursor-like proteins APLP1 and APLP2. J Alzheimers Dis. 2011; 23(4):689-99. PMID: 21178287.
      View in: PubMed
    39. Libeu CP, Poksay KS, John V, Bredesen DE. Structural and functional alterations in amyloid-ß precursor protein induced by amyloid-ß peptides. J Alzheimers Dis. 2011; 25(3):547-66. PMID: 21471643.
      View in: PubMed
    40. Descamps O, Zhang Q, John V, Bredesen DE. Induction of the C-terminal proteolytic cleavage of AßPP by statins. J Alzheimers Dis. 2011; 25(1):51-7. PMID: 21422530.
      View in: PubMed
    41. Sperandio S, Poksay KS, Schilling B, Crippen D, Gibson BW, Bredesen DE. Identification of new modulators and protein alterations in non-apoptotic programmed cell death. J Cell Biochem. 2010 Dec 15; 111(6):1401-12. PMID: 20830744.
      View in: PubMed
    42. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 01; 5(4):e9979. PMID: 20376313.
      View in: PubMed
    43. Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci. 2010 Jan 06; 30(1):372-81. PMID: 20053918.
      View in: PubMed
    44. Bredesen DE, John V, Galvan V. Importance of the caspase cleavage site in amyloid-ß protein precursor. J Alzheimers Dis. 2010; 22(1):57-63. PMID: 20847422.
      View in: PubMed
    45. Swistowski A, Zhang Q, Orcholski ME, Crippen D, Vitelli C, Kurakin A, Bredesen DE. Novel mediators of amyloid precursor protein signaling. J Neurosci. 2009 Dec 16; 29(50):15703-12. PMID: 20016085.
      View in: PubMed
    46. Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free Radic Biol Med. 2010 Jan 01; 48(1):136-44. PMID: 19854267.
      View in: PubMed
    47. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 2011 Sep; 32(9):1725-9. PMID: 19828212.
      View in: PubMed
    48. Zhang J, Gorostiza OF, Tang H, Bredesen DE, Galvan V. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res. 2010 Jan 20; 206(2):202-7. PMID: 19751769.
      View in: PubMed
    49. Park SA, Shaked GM, Bredesen DE, Koo EH. Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):450-5. PMID: 19679105.
      View in: PubMed
    50. Bredesen DE. Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener. 2009 Jun 26; 4:27. PMID: 19558683.
      View in: PubMed
    51. Mille F, Llambi F, Guix C, Delloye-Bourgeois C, Guenebeaud C, Castro-Obregon S, Bredesen DE, Thibert C, Mehlen P. Interfering with multimerization of netrin-1 receptors triggers tumor cell death. Cell Death Differ. 2009 Oct; 16(10):1344-51. PMID: 19543238.
      View in: PubMed
    52. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug; 16(8):1093-107. PMID: 19373242.
      View in: PubMed
    53. Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol. 2009 Mar; 65(3):294-303. PMID: 19334058.
      View in: PubMed
    54. Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, Bredesen DE, Mehlen P. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell Death Differ. 2009 May; 16(5):655-63. PMID: 19148186.
      View in: PubMed
    55. Chinta SJ, Poksay KS, Kaundinya G, Hart M, Bredesen DE, Andersen JK, Rao RV. Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci. 2009 Sep; 39(1-2):157-68. PMID: 19145491.
      View in: PubMed
    56. Ellerby HM, Bredesen DE, Fujimura S, John V. Hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2008 Oct 09; 51(19):5887-92. PMID: 18828573.
      View in: PubMed
    57. Chinta SJ, Rane A, Poksay KS, Bredesen DE, Andersen JK, Rao RV. Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat. Neuromolecular Med. 2008; 10(4):333-42. PMID: 18773310.
      View in: PubMed
    58. Rossi D, Brambilla L, Valori CF, Roncoroni C, Crugnola A, Yokota T, Bredesen DE, Volterra A. Focal degeneration of astrocytes in amyotrophic lateral sclerosis. Cell Death Differ. 2008 Nov; 15(11):1691-700. PMID: 18617894.
      View in: PubMed
    59. Bakhshi J, Weinstein L, Poksay KS, Nishinaga B, Bredesen DE, Rao RV. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis. 2008 Jul; 13(7):904-14. PMID: 18493855.
      View in: PubMed
    60. Bredesen DE. Programmed cell death mechanisms in neurological disease. Curr Mol Med. 2008 May; 8(3):173-86. PMID: 18473818.
      View in: PubMed
    61. Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE. Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res. 2008 Aug 22; 191(2):246-55. PMID: 18485495.
      View in: PubMed
    62. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb; 13(1):1-16. PMID: 18334752.
      View in: PubMed
    63. Bredesen DE, Rabizadeh S. APP-based neuroprotective strategies. Curr Alzheimer Res. 2007 Dec; 4(5):541-3. PMID: 18220517.
      View in: PubMed
    64. Levy RM, Bredesen DE, Rosenblum ML. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985. J Neurosurg. 2007 Dec; 107(6):1253-73; discussion 1251. PMID: 18077970.
      View in: PubMed
    65. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. PMID: 18188003.
      View in: PubMed
    66. Nguyen TV, Galvan V, Huang W, Banwait S, Tang H, Zhang J, Bredesen DE. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008 Feb; 104(4):1065-80. PMID: 17986220.
      View in: PubMed
    67. Galvan V, Bredesen DE. Neurogenesis in the adult brain: implications for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2007 Oct; 6(5):303-10. PMID: 18045158.
      View in: PubMed
    68. Kurakin A, Swistowski A, Wu SC, Bredesen DE. The PDZ domain as a complex adaptive system. PLoS One. 2007 Sep 26; 2(9):e953. PMID: 17895993.
      View in: PubMed
    69. Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J Biol Chem. 2007 Oct 12; 282(41):30150-60. PMID: 17646170.
      View in: PubMed
    70. Galvan V, Banwait S, Spilman P, Gorostiza OF, Peel A, Ataie M, Crippen D, Huang W, Sidhu G, Ichijo H, Bredesen DE. Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis. 2007 Oct; 28(1):65-75. PMID: 17719230.
      View in: PubMed
    71. del Rio G, Kane DJ, Ball KD, Bredesen DE. A novel motif identified in dependence receptors. PLoS One. 2007 May 23; 2(5):e463. PMID: 17520022.
      View in: PubMed
    72. Cusack MP, Thibert B, Bredesen DE, Del Rio G. Efficient identification of critical residues based only on protein structure by network analysis. PLoS One. 2007 May 09; 2(5):e421. PMID: 17502913.
      View in: PubMed
    73. Egger L, Madden DT, Rhême C, Rao RV, Bredesen DE. Endoplasmic reticulum stress-induced cell death mediated by the proteasome. Cell Death Differ. 2007 Jun; 14(6):1172-80. PMID: 17396132.
      View in: PubMed
    74. Madden DT, Egger L, Bredesen DE. A calpain-like protease inhibits autophagic cell death. Autophagy. 2007 Sep-Oct; 3(5):519-22. PMID: 17404499.
      View in: PubMed
    75. Bredesen DE. Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke. 2007 Feb; 38(2 Suppl):652-60. PMID: 17261709.
      View in: PubMed
    76. Kurakin A, Bredesen DE. An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain. J Mol Recognit. 2007 Jan-Feb; 20(1):39-50. PMID: 17094177.
      View in: PubMed
    77. Stoka V, Turk V, Bredesen DE. Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med. 2007; 9(3):255-63. PMID: 17914183.
      View in: PubMed
    78. Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci. 2006 Dec 27; 26(52):13428-36. PMID: 17192425.
      View in: PubMed
    79. Bredesen DE, Rao RV, Mehlen P. Cell death in the nervous system. Nature. 2006 Oct 19; 443(7113):796-802. PMID: 17051206.
      View in: PubMed
    80. Stoka V, Turk V, Bredesen DE. Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett. 2006 Jun 26; 580(15):3739-45. PMID: 16777102.
      View in: PubMed
    81. Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):7130-5. PMID: 16641106.
      View in: PubMed
    82. Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH. Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). FASEB J. 2006 Jun; 20(8):1254-6. PMID: 16636103.
      View in: PubMed
    83. Rao RV, Niazi K, Mollahan P, Mao X, Crippen D, Poksay KS, Chen S, Bredesen DE. Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23. Cell Death Differ. 2006 Mar; 13(3):415-25. PMID: 16195741.
      View in: PubMed
    84. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. PMID: 16264422.
      View in: PubMed
    85. Stoka V, Chen SF, Turk V, Bredesen DE. Developmental shift in the apostat: comparison of neurones and astrocytes. FEBS Lett. 2005 Nov 07; 579(27):6147-50. PMID: 16242128.
      View in: PubMed
    86. Thibert B, Bredesen DE, del Rio G. Improved prediction of critical residues for protein function based on network and phylogenetic analyses. BMC Bioinformatics. 2005 Aug 26; 6:213. PMID: 16124876.
      View in: PubMed
    87. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005 Aug; 58(2):277-89. PMID: 16049941.
      View in: PubMed
    88. Bredesen DE, Mehlen P, Rabizadeh S. Receptors that mediate cellular dependence. Cell Death Differ. 2005 Aug; 12(8):1031-43. PMID: 16015380.
      View in: PubMed
    89. Rao RV, Bredesen DE. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol. 2004 Dec; 16(6):653-62. PMID: 15530777.
      View in: PubMed
    90. Bredesen DE. Toward a mechanistic taxonomy of cell death programs. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S3-6. PMID: 15665411.
      View in: PubMed
    91. Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, Nasir J, Bredesen DE. Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ. 2004 Oct; 11(10):1066-75. PMID: 15195070.
      View in: PubMed
    92. Bredesen DE. The non-existent aging program: how does it work? Aging Cell. 2004 Oct; 3(5):255-9. PMID: 15379848.
      View in: PubMed
    93. Bredesen DE. Rebuttal to Austad: 'Is aging programmed? Aging Cell. 2004 Oct; 3(5):261-2. PMID: 15379849.
      View in: PubMed
    94. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, Mehlen P. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature. 2004 Sep 02; 431(7004):80-4. PMID: 15343335.
      View in: PubMed
    95. Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, Greenberg DA. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13363-7. PMID: 15340159.
      View in: PubMed
    96. Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M, Nishimoto I. Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD. J Neurochem. 2004 Aug; 90(3):549-58. PMID: 15255932.
      View in: PubMed
    97. Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 2004 Apr; 11(4):424-38. PMID: 14713958.
      View in: PubMed
    98. Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004 Apr; 11(4):372-80. PMID: 14765132.
      View in: PubMed
    99. Bredesen DE, Mehlen P, Rabizadeh S. Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev. 2004 Apr; 84(2):411-30. PMID: 15044679.
      View in: PubMed
    100. Castro-Obregón S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, Bredesen DE. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J Biol Chem. 2004 Apr 23; 279(17):17543-53. PMID: 14769794.
      View in: PubMed
    101. Yokota T, Miyagishi M, Hino T, Matsumura R, Tasinato A, Urushitani M, Rao RV, Takahashi R, Bredesen DE, Taira K, Mizusawa H, Andrea T. siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):283-91. PMID: 14715277.
      View in: PubMed
    102. Galvan V, Kurakin AV, Bredesen DE. Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. FEBS Lett. 2004 Jan 30; 558(1-3):57-62. PMID: 14759516.
      View in: PubMed
    103. Kurakin A, Wu S, Bredesen DE. Target-assisted iterative screening of phage surface display cDNA libraries. Methods Mol Biol. 2004; 264:47-60. PMID: 15020779.
      View in: PubMed
    104. Peel AL, Sorscher N, Kim JY, Galvan V, Chen S, Bredesen DE. Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex. Neuromolecular Med. 2004; 5(3):205-18. PMID: 15626821.
      View in: PubMed
    105. Mehlen P, Bredesen DE. The dependence receptor hypothesis. Apoptosis. 2004 Jan; 9(1):37-49. PMID: 14739597.
      View in: PubMed
    106. Mehlen P, Bredesen DE. Meeting report: cellular dependence--old concept, new mechanisms. Sci STKE. 2003 Dec 16; 2003(213):pe55. PMID: 14679288.
      View in: PubMed
    107. Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol. 2003 Dec; 54(6):781-9. PMID: 14681887.
      View in: PubMed
    108. Lu DC, Soriano S, Bredesen DE, Koo EH. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem. 2003 Nov; 87(3):733-41. PMID: 14535955.
      View in: PubMed
    109. Rao RV, Poksay KS, Castro-Obregon S, Schilling B, Row RH, del Rio G, Gibson BW, Ellerby HM, Bredesen DE. Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem. 2004 Jan 02; 279(1):177-87. PMID: 14561754.
      View in: PubMed
    110. Peel AL, Bredesen DE. Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol Dis. 2003 Oct; 14(1):52-62. PMID: 13678666.
      View in: PubMed
    111. Kurakin AV, Wu S, Bredesen DE. Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening. J Biol Chem. 2003 Sep 05; 278(36):34102-9. PMID: 12829691.
      View in: PubMed
    112. Rabizadeh S, Bredesen DE. Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). Cytokine Growth Factor Rev. 2003 Jun-Aug; 14(3-4):225-39. PMID: 12787561.
      View in: PubMed
    113. Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. An artificially designed pore-forming protein with anti-tumor effects. J Biol Chem. 2003 Sep 12; 278(37):35311-6. PMID: 12750379.
      View in: PubMed
    114. Galvan V, Logvinova A, Sperandio S, Ichijo H, Bredesen DE. Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem. 2003 Apr 11; 278(15):13325-32. PMID: 12556535.
      View in: PubMed
    115. Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci. 2002 Sep 15; 22(18):7862-72. PMID: 12223539.
      View in: PubMed
    116. Castro-Obregón S, Del Rio G, Chen SF, Swanson RA, Frankowski H, Rao RV, Stoka V, Vesce S, Nicholls DG, Bredesen DE. A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ. 2002 Aug; 9(8):807-17. PMID: 12107824.
      View in: PubMed
    117. Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE. Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem. 2002 Jul; 82(2):283-94. PMID: 12124429.
      View in: PubMed
    118. Kurakin A, Bredesen D. Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins. J Biomol Struct Dyn. 2002 Jun; 19(6):1015-29. PMID: 12023804.
      View in: PubMed
    119. Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, del Rio G, Bredesen DE, Ellerby HM. Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem. 2002 Jun 14; 277(24):21836-42. PMID: 11919205.
      View in: PubMed
    120. Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002 Mar 13; 514(2-3):122-8. PMID: 11943137.
      View in: PubMed
    121. Arap W, Haedicke W, Bernasconi M, Kain R, Rajotte D, Krajewski S, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E. Targeting the prostate for destruction through a vascular address. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1527-31. PMID: 11830668.
      View in: PubMed
    122. Frankowski H, Castro-Obregon S, del Rio G, Rao RV, Bredesen DE. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. Neuromolecular Med. 2002; 1(3):153-70. PMID: 12095158.
      View in: PubMed
    123. Ethell DW, Bossy-Wetzel E, Bredesen DE. Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro. Biochim Biophys Acta. 2001 Dec 19; 1541(3):231-8. PMID: 11755217.
      View in: PubMed
    124. Lee M, Hyun DH, Marshall KA, Ellerby LM, Bredesen DE, Jenner P, Halliwell B. Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radic Biol Med. 2001 Dec 15; 31(12):1550-9. PMID: 11744329.
      View in: PubMed
    125. del Rio G, Bartley TF, del-Rio H, Rao R, Jin KL, Greenberg DA, Eshoo M, Bredesen DE. Mining DNA microarray data using a novel approach based on graph theory. FEBS Lett. 2001 Dec 07; 509(2):230-4. PMID: 11741594.
      View in: PubMed
    126. Bredesen DE. Neurodegenerative disease and cancer: two sides of a coin? Hosp Pract (1995). 2001 Sep 15; 36(9):39-42, 45. PMID: 11565741.
      View in: PubMed
    127. Gerlag DM, Borges E, Tak PP, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E, Firestein GS. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arthritis Res. 2001; 3(6):357-61. PMID: 11714389.
      View in: PubMed
    128. Zhong LT, Manzi A, Skowronski E, Notterpek L, Fluharty AL, Faull KF, Masada I, Rabizadeh S, Varsanyi-Nagy M, Ruan Y, Oh JD, Butcher LL, Bredesen DE. A monoclonal antibody that induces neuronal apoptosis binds a metastasis marker. Cancer Res. 2001 Aug 01; 61(15):5741-8. PMID: 11479210.
      View in: PubMed
    129. Peel AL, Rao RV, Cottrell BA, Hayden MR, Ellerby LM, Bredesen DE. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Hum Mol Genet. 2001 Jul 15; 10(15):1531-8. PMID: 11468270.
      View in: PubMed
    130. Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem. 2001 Sep 07; 276(36):33869-74. PMID: 11448953.
      View in: PubMed
    131. Lee S, Furuya T, Kiyota T, Takami N, Murata K, Niidome Y, Bredesen DE, Ellerby HM, Sugihara G. De novo-designed peptide transforms Golgi-specific lipids into Golgi-like nanotubules. J Biol Chem. 2001 Nov 02; 276(44):41224-8. PMID: 11406635.
      View in: PubMed
    132. del Rio G, Castro-Obregon S, Rao R, Ellerby HM, Bredesen DE. APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide. FEBS Lett. 2001 Apr 13; 494(3):213-9. PMID: 11311243.
      View in: PubMed
    133. Forcet C, Ye X, Granger L, Corset V, Shin H, Bredesen DE, Mehlen P. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3416-21. PMID: 11248093.
      View in: PubMed
    134. Sperandio S, de Belle I, Bredesen DE. An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14376-81. PMID: 11121041.
      View in: PubMed
    135. Rabizadeh S, Ye X, Sperandio S, Wang JJ, Ellerby HM, Ellerby LM, Giza C, Andrusiak RL, Frankowski H, Yaron Y, Moayeri NN, Rovelli G, Evans CJ, Butcher LL, Nolan GP, Assa-Munt N, Bredesen DE. Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor. J Mol Neurosci. 2000 Dec; 15(3):215-29. PMID: 11303785.
      View in: PubMed
    136. Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem. 2001 Feb 02; 276(5):3149-57. PMID: 11073962.
      View in: PubMed
    137. Cafe C, Testa MP, Sheldon PJ, French WP, Ellerby LM, Bredesen DE. Loss of oxidation-reduction specificity in amyotrophic lateral sclerosis-associated CuZnSOD mutants. J Mol Neurosci. 2000 Oct; 15(2):71-83. PMID: 11220787.
      View in: PubMed
    138. Bredesen DE. Apoptosis: overview and signal transduction pathways. J Neurotrauma. 2000 Oct; 17(10):801-10. PMID: 11063049.
      View in: PubMed
    139. Bordeaux MC, Forcet C, Granger L, Corset V, Bidaud C, Billaud M, Bredesen DE, Edery P, Mehlen P. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J. 2000 Aug 01; 19(15):4056-63. PMID: 10921886.
      View in: PubMed
    140. Wang JJ, Tasinato A, Ethell DW, Testa MP, Bredesen DE. Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities. J Mol Neurosci. 2000 Aug; 15(1):19-29. PMID: 11211234.
      View in: PubMed
    141. Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE, Chuang DM. Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression. J Neurochem. 2000 Jul; 75(1):81-90. PMID: 10854250.
      View in: PubMed
    142. Mehlen P, Bredesen DE. [Dependence receptors: links between apoptosis, nervous system development and control of tumorigenesis]. Bull Cancer. 2000 Jul; 87(7-8):537-41. PMID: 10969210.
      View in: PubMed
    143. Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J Biol Chem. 2000 Jun 30; 275(26):19831-8. PMID: 10770929.
      View in: PubMed
    144. Wang JJ, Rabizadeh S, Tasinato A, Sperandio S, Ye X, Green M, Assa-Munt N, Spencer D, Bredesen DE. Dimerization-dependent block of the proapoptotic effect of p75(NTR). J Neurosci Res. 2000 Jun 01; 60(5):587-93. PMID: 10820429.
      View in: PubMed
    145. Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem. 2000 May 26; 275(21):16127-33. PMID: 10821864.
      View in: PubMed
    146. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000 Apr; 6(4):397-404. PMID: 10742146.
      View in: PubMed
    147. Kelner GS, Lee M, Clark ME, Maciejewski D, McGrath D, Rabizadeh S, Lyons T, Bredesen D, Jenner P, Maki RA. The copper transport protein Atox1 promotes neuronal survival. J Biol Chem. 2000 Jan 07; 275(1):580-4. PMID: 10617654.
      View in: PubMed
    148. Ellerby LM, Bredesen DE. Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis. Methods Enzymol. 2000; 322:413-21. PMID: 10914037.
      View in: PubMed
    149. Rabizadeh S, Rabizadeh S, Ye X, Wang JJ, Bredesen DE. Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF. Cell Death Differ. 1999 Dec; 6(12):1222-7. PMID: 10637439.
      View in: PubMed
    150. Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. FEBS Lett. 1999 Oct 29; 460(2):191-8. PMID: 10544233.
      View in: PubMed
    151. Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem. 1999 Oct 15; 274(42):30202-8. PMID: 10514511.
      View in: PubMed
    152. Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med. 1999 Sep; 5(9):1032-8. PMID: 10470080.
      View in: PubMed
    153. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5752-7. PMID: 10318956.
      View in: PubMed
    154. Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem. 1999 Mar 26; 274(13):8730-6. PMID: 10085113.
      View in: PubMed
    155. Hong CS, Caromile L, Nomata Y, Mori H, Bredesen DE, Koo EH. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. J Neurosci. 1999 Jan 15; 19(2):637-43. PMID: 9880584.
      View in: PubMed
    156. Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem. 1999 Jan; 72(1):185-95. PMID: 9886069.
      View in: PubMed
    157. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature. 1998 Oct 22; 395(6704):801-4. PMID: 9796814.
      View in: PubMed
    158. Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90. PMID: 9765224.
      View in: PubMed
    159. Spear N, Estévez AG, Johnson GV, Bredesen DE, Thompson JA, Beckman JS. Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2. Arch Biochem Biophys. 1998 Aug 01; 356(1):41-5. PMID: 9681989.
      View in: PubMed
    160. Wei H, Wei W, Bredesen DE, Perry DC. Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores. J Neurochem. 1998 Jun; 70(6):2305-14. PMID: 9603195.
      View in: PubMed
    161. Bredesen DE, Ye X, Tasinato A, Sperandio S, Wang JJ, Assa-Munt N, Rabizadeh S. p75NTR and the concept of cellular dependence: seeing how the other half die. Cell Death Differ. 1998 May; 5(5):365-71. PMID: 10200485.
      View in: PubMed
    162. Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):4997-5002. PMID: 9560217.
      View in: PubMed
    163. Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem. 1998 Apr 10; 273(15):9158-67. PMID: 9535906.
      View in: PubMed
    164. Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates. Nat Genet. 1998 Feb; 18(2):150-4. PMID: 9462744.
      View in: PubMed
    165. Bruce-Keller AJ, Begley JG, Fu W, Butterfield DA, Bredesen DE, Hutchins JB, Hensley K, Mattson MP. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide. J Neurochem. 1998 Jan; 70(1):31-9. PMID: 9422344.
      View in: PubMed
    166. Ruan Y, Rabizadeh S, Camerini D, Bredesen DE. Expression of CD40 induces neural apoptosis. J Neurosci Res. 1997 Nov 01; 50(3):383-90. PMID: 9364323.
      View in: PubMed
    167. Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci. 1997 Oct 15; 17(20):7594-605. PMID: 9315882.
      View in: PubMed
    168. Hileman MR, Chapman BS, Rabizadeh S, Krishnan VV, Bredesen D, Assa-Munt N, Plesniak LA. A cytoplasmic peptide of the neurotrophin receptor p75NTR: induction of apoptosis and NMR determined helical conformation. FEBS Lett. 1997 Sep 29; 415(2):145-54. PMID: 9350985.
      View in: PubMed
    169. Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE. Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci. 1997 Aug 15; 17(16):6165-78. PMID: 9236228.
      View in: PubMed
    170. Bredesen DE, Ellerby LM, Hart PJ, Wiedau-Pazos M, Valentine JS. Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis? Ann Neurol. 1997 Aug; 42(2):135-7. PMID: 9266721.
      View in: PubMed
    171. Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci. 1997 Jul 01; 17(13):5089-100. PMID: 9185546.
      View in: PubMed
    172. Bredesen DE, Rabizadeh S. p75NTR and apoptosis: Trk-dependent and Trk-independent effects. Trends Neurosci. 1997 Jul; 20(7):287-90. PMID: 9223218.
      View in: PubMed
    173. Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol. 1997 Jun 30; 137(7):1581-8. PMID: 9199172.
      View in: PubMed
    174. Keane RW, Srinivasan A, Foster LM, Testa MP, Ord T, Nonner D, Wang HG, Reed JC, Bredesen DE, Kayalar C. Activation of CPP32 during apoptosis of neurons and astrocytes. J Neurosci Res. 1997 Apr 15; 48(2):168-80. PMID: 9130145.
      View in: PubMed
    175. Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Café C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS. Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12240-4. PMID: 8901564.
      View in: PubMed
    176. Bredesen DE, Wiedau-Pazos M, Goto JJ, Rabizadeh S, Roe JA, Gralla EB, Ellerby LM, Valentine JS. Cell death mechanisms in ALS. Neurology. 1996 Oct; 47(4 Suppl 2):S36-8; discussion S38-9. PMID: 8858049.
      View in: PubMed
    177. Srinivasan A, Foster LM, Testa MP, Ord T, Keane RW, Bredesen DE, Kayalar C. Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis. J Neurosci. 1996 Sep 15; 16(18):5654-60. PMID: 8795621.
      View in: PubMed
    178. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9893-8. PMID: 8790427.
      View in: PubMed
    179. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem. 1996 Sep; 67(3):1259-67. PMID: 8752134.
      View in: PubMed
    180. Kayalar C, Ord T, Testa MP, Zhong LT, Bredesen DE. Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2234-8. PMID: 8700913.
      View in: PubMed
    181. Wiedau-Pazos M, Trudell JR, Altenbach C, Kane DJ, Hubbell WL, Bredesen DE. Expression of bcl-2 inhibits cellular radical generation. Free Radic Res. 1996 Mar; 24(3):205-12. PMID: 8728122.
      View in: PubMed
    182. Wiedau-Pazos M, Goto JJ, Rabizadeh S, Gralla EB, Roe JA, Lee MK, Valentine JS, Bredesen DE. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science. 1996 Jan 26; 271(5248):515-8. PMID: 8560268.
      View in: PubMed
    183. Sarafian TA, Bredesen DE, Verity MA. Cellular resistance to methylmercury. Neurotoxicology. 1996; 17(1):27-36. PMID: 8784816.
      View in: PubMed
    184. Bredesen DE. Genetic control of neural cell apoptosis. Perspect Dev Neurobiol. 1996; 3(2):101-9. PMID: 8826528.
      View in: PubMed
    185. Myers KM, Fiskum G, Liu Y, Simmens SJ, Bredesen DE, Murphy AN. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem. 1995 Dec; 65(6):2432-40. PMID: 7595537.
      View in: PubMed
    186. Bredesen DE. Neural apoptosis. Ann Neurol. 1995 Dec; 38(6):839-51. PMID: 8526456.
      View in: PubMed
    187. Verity MA, Bredesen DE, Sarafian T. Role of reactive oxygen species (ROS) in neuronal degeneration. Modulation by protooncogene expression. Ann N Y Acad Sci. 1995 Sep 15; 765:340. PMID: 7486641.
      View in: PubMed
    188. Hisanaga K, Kure S, Bredesen DE, Ikeda Y, Kohsaka S, Sharp FR. Apoptotic cell death of a temperature-sensitive central neuronal cell line. Brain Res. 1995 Jun 26; 684(1):79-86. PMID: 7583207.
      View in: PubMed
    189. Rabizadeh S, Gralla EB, Borchelt DR, Gwinn R, Valentine JS, Sisodia S, Wong P, Lee M, Hahn H, Bredesen DE. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):3024-8. PMID: 7708768.
      View in: PubMed
    190. Kane DJ, Ord T, Anton R, Bredesen DE. Expression of bcl-2 inhibits necrotic neural cell death. J Neurosci Res. 1995 Feb 01; 40(2):269-75. PMID: 7745620.
      View in: PubMed
    191. Anton R, Kordower JH, Kane DJ, Markham CH, Bredesen DE. Neural transplantation of cells expressing the anti-apoptotic gene bcl-2. Cell Transplant. 1995 Jan-Feb; 4(1):49-54. PMID: 7728333.
      View in: PubMed
    192. Sarafian TA, Vartavarian L, Kane DJ, Bredesen DE, Verity MA. bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line. Toxicol Lett. 1994 Nov; 74(2):149-55. PMID: 7940596.
      View in: PubMed
    193. Rabizadeh S, Bitler CM, Butcher LL, Bredesen DE. Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10703-6. PMID: 7938014.
      View in: PubMed
    194. Sarafian TA, Bredesen DE. Is apoptosis mediated by reactive oxygen species? Free Radic Res. 1994 Jul; 21(1):1-8. PMID: 7951907.
      View in: PubMed
    195. Rabizadeh S, Bredesen DE. Is p75NGFR involved in developmental neural cell death? Dev Neurosci. 1994; 16(3-4):207-11. PMID: 7535682.
      View in: PubMed
    196. Rabizadeh S, LaCount DJ, Friesen PD, Bredesen DE. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J Neurochem. 1993 Dec; 61(6):2318-21. PMID: 8245984.
      View in: PubMed
    197. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 1993 Nov 19; 262(5137):1274-7. PMID: 8235659.
      View in: PubMed
    198. Garcia PA, Bredesen DE, Vinters HV, Graefin von Einsiedel R, Williams RL, Kahn JO, Byers VS, Levin AS, Waites LA, Messing RO. Neurological reactions in HIV-infected patients treated with trichosanthin. Neuropathol Appl Neurobiol. 1993 Oct; 19(5):402-5. PMID: 8278023.
      View in: PubMed
    199. Zhong LT, Kane DJ, Bredesen DE. BCL-2 blocks glutamate toxicity in neural cell lines. Brain Res Mol Brain Res. 1993 Sep; 19(4):353-5. PMID: 7901730.
      View in: PubMed
    200. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE. Induction of apoptosis by the low-affinity NGF receptor. Science. 1993 Jul 16; 261(5119):345-8. PMID: 8332899.
      View in: PubMed
    201. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4533-7. PMID: 8506295.
      View in: PubMed
    202. Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH, Bredesen DE. The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J Neurochem. 1993 Mar; 60(3):1183-6. PMID: 8436969.
      View in: PubMed
    203. Verity AN, Bredesen D, Vonderscher C, Handley VW, Campagnoni AT. Expression of myelin protein genes and other myelin components in an oligodendrocytic cell line conditionally immortalized with a temperature-sensitive retrovirus. J Neurochem. 1993 Feb; 60(2):577-87. PMID: 7678286.
      View in: PubMed
    204. Foster LM, Phan T, Verity AN, Bredesen D, Campagnoni AT. Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation. Dev Neurosci. 1993; 15(2):100-9. PMID: 8168435.
      View in: PubMed
    205. Yang J, Seelig M, Rayner S, Bredesen DE. Increasing the proliferative capacity of muscular dystrophy myoblasts. Muscle Nerve. 1992 Aug; 15(8):941-8. PMID: 1495511.
      View in: PubMed
    206. Bredesen DE, Kane DJ, Holtzman DM, Epstein CJ. Preliminary characterization of long-term reaggregating cultures of trisomy 16 central nervous system. Prog Clin Biol Res. 1992; 379:259-70. PMID: 1409749.
      View in: PubMed
    207. Kahn JO, Kaplan LD, Gambertoglio JG, Bredesen D, Arri CJ, Turin L, Kibort T, Williams RL, Lifson JD, Volberding PA. The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study. AIDS. 1990 Dec; 4(12):1197-204. PMID: 2088398.
      View in: PubMed
    208. Levy RM, Bredesen DE, Rosenblum ML. Neurologic complications of HIV infection. Am Fam Physician. 1990 Feb; 41(2):517-36. PMID: 2154083.
      View in: PubMed
    209. Bredesen DE, Hisanaga K, Sharp FR. Neural transplantation using temperature-sensitive immortalized neural cells: a preliminary report. Ann Neurol. 1990 Feb; 27(2):205-7. PMID: 2156481.
      View in: PubMed
    210. Levy RM, Mills CM, Posin JP, Moore SG, Rosenblum ML, Bredesen DE. The efficacy and clinical impact of brain imaging in neurologically symptomatic AIDS patients: a prospective CT/MRI study. J Acquir Immune Defic Syndr (1988). 1990; 3(5):461-71. PMID: 2324943.
      View in: PubMed
    211. Ho DD, Bredesen DE, Vinters HV, Daar ES. The acquired immunodeficiency syndrome (AIDS) dementia complex. Ann Intern Med. 1989 Sep 01; 111(5):400-10. PMID: 2548429.
      View in: PubMed
    212. Engstrom JW, Lowenstein DH, Bredesen DE. Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome. Am J Med. 1989 May; 86(5):528-32. PMID: 2712060.
      View in: PubMed
    213. Levy RM, Bredesen DE. Controversies in HIV-related central nervous system disease: neuropsychological aspects of HIV-1 infection. AIDS Clin Rev. 1989; 151-91. PMID: 2488690.
      View in: PubMed
    214. Levy RM, Bredesen DE, Rosenblum ML, Davis RL. Central nervous system disorders in AIDS. Immunol Ser. 1989; 44:371-401. PMID: 2489119.
      View in: PubMed
    215. Bredesen DE, Levy RM, Rosenblum ML. The neurology of human immunodeficiency virus infection. Q J Med. 1988 Sep; 68(257):665-77. PMID: 2855754.
      View in: PubMed
    216. Scott MR, Butler DA, Bredesen DE, Wälchli M, Hsiao KK, Prusiner SB. Prion protein gene expression in cultured cells. Protein Eng. 1988 Apr; 2(1):69-76. PMID: 2908139.
      View in: PubMed
    217. Rosenblum ML, Levy RM, Bredesen DE, So YT, Wara W, Ziegler JL. Primary central nervous system lymphomas in patients with AIDS. Ann Neurol. 1988; 23 Suppl:S13-6. PMID: 2894803.
      View in: PubMed
    218. Rosenblum ML, Levy RM, Bredesen DE. Neurosurgical implications of the acquired immunodeficiency syndrome (AIDS). Clin Neurosurg. 1988; 34:419-45. PMID: 3288404.
      View in: PubMed
    219. Levy RM, Bredesen DE, Rosenblum ML. Opportunistic central nervous system pathology in patients with AIDS. Ann Neurol. 1988; 23 Suppl:S7-12. PMID: 2831804.
      View in: PubMed
    220. Levy RM, Bredesen DE. Central nervous system dysfunction in acquired immunodeficiency syndrome. J Acquir Immune Defic Syndr (1988). 1988; 1(1):41-64. PMID: 3063805.
      View in: PubMed
    221. Dix RD, Bredesen DE, Erlich KS, Mills J. Recovery of herpesviruses from cerebrospinal fluid of immunodeficient homosexual men. Ann Neurol. 1985 Nov; 18(5):611-4. PMID: 3000285.
      View in: PubMed
    222. Parry GJ, Bredesen DE. Sensory neuropathy with low-dose pyridoxine. Neurology. 1985 Oct; 35(10):1466-8. PMID: 2993949.
      View in: PubMed
    223. Levy RM, Bredesen DE, Rosenblum ML. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg. 1985 Apr; 62(4):475-95. PMID: 2983051.
      View in: PubMed
    224. Bredesen DE. Neurology: neurologic manifestations of AIDS. West J Med. 1985 Jan; 142(1):84. PMID: 18749682.
      View in: PubMed
    225. Raskin NH, Bredesen D, Ehrenfeld WK, Kerlan RK. Periodic confusion caused by congenital extrahepatic portacaval shunt. Neurology. 1984 May; 34(5):666-9. PMID: 6538657.
      View in: PubMed
    226. Cutler JR, Bredesen DE, Edwards R, Simon RP. Failure of naloxone to reverse vascular neurologic deficits. Neurology. 1983 Nov; 33(11):1517-8. PMID: 6685246.
      View in: PubMed
    227. McCarty KS, Bredesen DE, Vogel FS. Neoplasms of the anterior pituitary. Neurosurgery. 1978 Jul-Aug; 3(1):96-104. PMID: 210418.
      View in: PubMed