Daniel L Clemens

Title(s)Adjunct Professor, Medicine
SchoolMedicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells. Mucosal Immunol. 2024 Apr; 17(2):155-168. Olmo-Fontánez AM, Scordo JM, Schami A, Garcia-Vilanova A, Pino PA, Hicks A, Mishra R, Jose Maselli D, Peters JI, Restrepo BI, Nargan K, Naidoo T, Clemens DL, Steyn AJC, Thacker VV, Turner J, Schlesinger LS, Torrelles JB. PMID: 38185331; PMCID: PMC11034793.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    2. Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial. Emerg Microbes Infect. 2023 Dec; 12(1):2187247. Zheng X, Gui X, Yao L, Ma J, He Y, Lou H, Gu J, Ying R, Chen L, Sun Q, Liu Y, Ho CM, Lee BY, Clemens DL, Horwitz MA, Ding X, Hao X, Yang H, Sha W. PMID: 36872899; PMCID: PMC10026740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System. mBio. 2022 10 26; 13(5):e0127722. Liu X, Clemens DL, Lee BY, Yang X, Zhou ZH, Horwitz MA. PMID: 36036641; PMCID: PMC9600919.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo. Structure. 2019 12 03; 27(12):1811-1819.e6. Yang X, Clemens DL, Lee BY, Cui Y, Zhou ZH, Horwitz MA. PMID: 31677891; PMCID: PMC6939872.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Intracellular Photothermal Delivery for Suspension Cells Using Sharp Nanoscale Tips in Microwells. ACS Nano. 2019 09 24; 13(9):10835-10844. Man T, Zhu X, Chow YT, Dawson ER, Wen X, Patananan AN, Liu TL, Zhao C, Wu C, Hong JS, Chung PS, Clemens DL, Lee BY, Weiss PS, Teitell MA, Chiou PY. PMID: 31487464.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    6. Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs. PLoS One. 2019; 14(5):e0215607. Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. PMID: 31075149; PMCID: PMC6510528.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model. ACS Infect Dis. 2019 02 08; 5(2):281-291. Clemens DL, Lee BY, Plamthottam S, Tullius MV, Wang R, Yu CJ, Li Z, Dillon BJ, Zink JI, Horwitz MA. PMID: 30480992.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility. PLoS One. 2018; 13(11):e0207469. Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ho CM, Horwitz MA. PMID: 30427938; PMCID: PMC6235396.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces. 2018 Sep 26; 10(38):31870-31881. Chen W, Cheng CA, Lee BY, Clemens DL, Huang WY, Horwitz MA, Zink JI. PMID: 30160469.
      View in: PubMed   Mentions: 22     Fields:    
    10. The Francisella Type VI Secretion System. Front Cell Infect Microbiol. 2018; 8:121. Clemens DL, Lee BY, Horwitz MA. PMID: 29740542; PMCID: PMC5924787.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    11. A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles. J Am Chem Soc. 2017 05 17; 139(19):6663-6668. Ruehle B, Clemens DL, Lee BY, Horwitz MA, Zink JI. PMID: 28437093.
      View in: PubMed   Mentions: 15     Fields:    
    12. Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time. Nat Commun. 2017 01 24; 8:14183. Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. PMID: 28117835; PMCID: PMC5287291.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    13. Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. Small. 2016 Jul; 12(27):3690-702. Lee BY, Li Z, Clemens DL, Dillon BJ, Hwang AA, Zink JI, Horwitz MA. PMID: 27246117.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    14. Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):E2172-9. Silva A, Lee BY, Clemens DL, Kee T, Ding X, Ho CM, Horwitz MA. PMID: 27035987; PMCID: PMC4839402.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    15. Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia. ACS Nano. 2015 Nov 24; 9(11):10778-89. Li Z, Clemens DL, Lee BY, Dillon BJ, Horwitz MA, Zink JI. PMID: 26435204.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    16. Tuberculosis: pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015). Small. 2015 Oct; 11(38):5065. Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. PMID: 26450161.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    17. pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice. Small. 2015 Oct; 11(38):5066-78. Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. PMID: 26193431; PMCID: PMC5628743.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    18. Massively parallel delivery of large cargo into mammalian cells with light pulses. Nat Methods. 2015 May; 12(5):439-44. Wu YC, Wu TH, Clemens DL, Lee BY, Wen X, Horwitz MA, Teitell MA, Chiou PY. PMID: 25849636; PMCID: PMC5082232.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    19. Atomic structure of T6SS reveals interlaced array essential to function. Cell. 2015 Feb 26; 160(5):940-951. Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH. PMID: 25723168; PMCID: PMC4351867.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    20. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4904-12. Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. PMID: 24191014; PMCID: PMC3864319.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    21. Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012 May; 56(5):2535-45. Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA. PMID: 22354311; PMCID: PMC3346638.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    22. O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages. Infect Immun. 2012 Mar; 80(3):952-67. Clemens DL, Lee BY, Horwitz MA. PMID: 22202123; PMCID: PMC3294633.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    23. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics. 2010 Jan; 9(1):32-53. Lee BY, Jethwaney D, Schilling B, Clemens DL, Gibson BW, Horwitz MA. PMID: 19815536; PMCID: PMC2808266.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    24. Francisella tularensis phagosomal escape does not require acidification of the phagosome. Infect Immun. 2009 May; 77(5):1757-73. Clemens DL, Lee BY, Horwitz MA. PMID: 19237528; PMCID: PMC2681761.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    25. Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis. Vaccine. 2009 Feb 18; 27(8):1216-29. Jia Q, Lee BY, Clemens DL, Bowen RA, Horwitz MA. PMID: 19126421; PMCID: PMC2654553.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    26. The metabolic activity of Mycobacterium tuberculosis, assessed by use of a novel inducible GFP expression system, correlates with its capacity to inhibit phagosomal maturation and acidification in human macrophages. Mol Microbiol. 2008 May; 68(4):1047-60. Lee BY, Clemens DL, Horwitz MA. PMID: 18363792; PMCID: PMC3591484.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    27. Uptake and intracellular fate of Francisella tularensis in human macrophages. Ann N Y Acad Sci. 2007 Jun; 1105:160-86. Clemens DL, Horwitz MA. PMID: 17435118.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    28. Identification, recombinant expression, immunolocalization in macrophages, and T-cell responsiveness of the major extracellular proteins of Francisella tularensis. Infect Immun. 2006 Jul; 74(7):4002-13. Lee BY, Horwitz MA, Clemens DL. PMID: 16790773; PMCID: PMC1489726.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    29. Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun. 2005 Sep; 73(9):5892-902. Clemens DL, Lee BY, Horwitz MA. PMID: 16113308; PMCID: PMC1231130.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    30. Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun. 2004 Jun; 72(6):3204-17. Clemens DL, Lee BY, Horwitz MA. PMID: 15155622; PMCID: PMC415696.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansCells
    31. Conservation of CD1 intracellular trafficking patterns between mammalian species. J Immunol. 2002 Dec 15; 169(12):6951-8. Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB. PMID: 12471129.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. The Mycobacterium tuberculosis phagosome in human macrophages is isolated from the host cell cytoplasm. Infect Immun. 2002 Oct; 70(10):5800-7. Clemens DL, Lee BY, Horwitz MA. PMID: 12228310; PMCID: PMC128330.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Mycobacterium tuberculosis and Legionella pneumophila phagosomes exhibit arrested maturation despite acquisition of Rab7. Infect Immun. 2000 Sep; 68(9):5154-66. Clemens DL, Lee BY, Horwitz MA. PMID: 10948139; PMCID: PMC101766.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    34. Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. Infect Immun. 2000 May; 68(5):2671-84. Clemens DL, Lee BY, Horwitz MA. PMID: 10768959; PMCID: PMC97474.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
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