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Campbell, David A

Title(s)Professor, Mimg
Phone65556
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    Collapse Research 
    Collapse Research Activities and Funding
    Cap binding and gene expression in trypanosomes
    NIH/FIC R03TW009035Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator
    Translational partitioning of the SL RNA
    NIH/NIAID R21AI073806Jun 1, 2009 - May 31, 2012
    Role: Principal Investigator
    Global sumoylation analysis in Trypanosoma brucei
    NIH/NIAID R21AI079639May 5, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Kinetoplastid SL RNA Biogenesis
    NIH/NIAID R01AI056034Apr 1, 2004 - Mar 31, 2009
    Role: Principal Investigator
    EXPRESSION OF THE LEISHMANIA TARENTOLAE SL RNA GENE
    NIH/NIAID R01AI034536Dec 1, 1994 - Nov 30, 1998
    Role: Principal Investigator
    DNA-BINDING PROTEINS IN TRYPANOSOMA BRUCEI
    NIH/NIAID R01AI024455Jul 1, 1988 - Jun 30, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Freire ER, Moura DMN, Bezerra MJR, Xavier CC, Morais-Sobral MC, Vashisht AA, Rezende AM, Wohlschlegel JA, Sturm NR, de Melo Neto OP, Campbell DA. Trypanosoma brucei EIF4E2 cap-binding protein binds a homolog of the histone-mRNA stem-loop-binding protein. Curr Genet. 2018 Aug; 64(4):821-839. PMID: 29288414.
      View in: PubMed
    2. Freire ER, Sturm NR, Campbell DA, de Melo Neto OP. The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. Pathogens. 2017 Oct 27; 6(4). PMID: 29077018.
      View in: PubMed
    3. Yang F, Xu D, Zhuang Y, Yi X, Huang Y, Chen H, Lin S, Campbell DA, Sturm NR, Liu G, Zhang H. Spliced leader RNA trans-splicing discovered in copepods. Sci Rep. 2015 Dec 01; 5:17411. PMID: 26621068.
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    4. Lin S, Cheng S, Song B, Zhong X, Lin X, Li W, Li L, Zhang Y, Zhang H, Ji Z, Cai M, Zhuang Y, Shi X, Lin L, Wang L, Wang Z, Liu X, Yu S, Zeng P, Hao H, Zou Q, Chen C, Li Y, Wang Y, Xu C, Meng S, Xu X, Wang J, Yang H, Campbell DA, Sturm NR, Dagenais-Bellefeuille S, Morse D. The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis. Science. 2015 Nov 06; 350(6261):691-4. PMID: 26542574.
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    5. Freire ER, Vashisht AA, Malvezzi AM, Zuberek J, Langousis G, Saada EA, Nascimento Jde F, Stepinski J, Darzynkiewicz E, Hill K, De Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei. RNA. 2014 Aug; 20(8):1272-86. PMID: 24962368.
      View in: PubMed
    6. Freire ER, Malvezzi AM, Vashisht AA, Zuberek J, Saada EA, Langousis G, Nascimento JD, Moura D, Darzynkiewicz E, Hill K, de Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog. Eukaryot Cell. 2014 Jul; 13(7):896-908. PMID: 24839125.
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    7. Porcel BM, Denoeud F, Opperdoes F, Noel B, Madoui MA, Hammarton TC, Field MC, Da Silva C, Couloux A, Poulain J, Katinka M, Jabbari K, Aury JM, Campbell DA, Cintron R, Dickens NJ, Docampo R, Sturm NR, Koumandou VL, Fabre S, Flegontov P, Lukeš J, Michaeli S, Mottram JC, Szöor B, Zilberstein D, Bringaud F, Wincker P, Dollet M. The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genet. 2014 Feb; 10(2):e1004007. PMID: 24516393.
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    8. Zhang H, Campbell DA, Sturm NR, Rosenblad MA, Dungan CF, Lin S. Signal recognition particle RNA in dinoflagellates and the Perkinsid Perkinsus marinus. Protist. 2013 Sep; 164(5):748-61. PMID: 23994724.
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    9. Zingales B, Miles MA, Campbell DA, Tibayrenc M, Macedo AM, Teixeira MM, Schijman AG, Llewellyn MS, Lages-Silva E, Machado CR, Andrade SG, Sturm NR. The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. Infect Genet Evol. 2012 Mar; 12(2):240-53. PMID: 22226704.
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    10. Dollet M, Sturm NR, Campbell DA. The internal transcribed spacer of ribosomal RNA genes in plant trypanosomes (Phytomonas spp.) resolves 10 groups. Infect Genet Evol. 2012 Mar; 12(2):299-308. PMID: 22155359.
      View in: PubMed
    11. Zhang H, Campbell DA, Sturm NR, Dungan CF, Lin S. Spliced leader RNAs, mitochondrial gene frameshifts and multi-protein phylogeny expand support for the genus Perkinsus as a unique group of alveolates. PLoS One. 2011; 6(5):e19933. PMID: 21629701.
      View in: PubMed
    12. Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Nucleic Acids Res. 2011 Jun; 39(11):4756-68. PMID: 21310715.
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    13. Sturm NR, Campbell DA. Alternative lifestyles: the population structure of Trypanosoma cruzi. Acta Trop. 2010 Jul-Aug; 115(1-2):35-43. PMID: 19695212.
      View in: PubMed
    14. Zamudio JR, Mittra B, Campbell DA, Sturm NR. Hypermethylated cap 4 maximizes Trypanosoma brucei translation. Mol Microbiol. 2009 Jun; 72(5):1100-10. PMID: 19504740.
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    15. Zhang H, Campbell DA, Sturm NR, Lin S. Dinoflagellate spliced leader RNA genes display a variety of sequences and genomic arrangements. Mol Biol Evol. 2009 Aug; 26(8):1757-71. PMID: 19387009.
      View in: PubMed
    16. Thomas S, Green A, Sturm NR, Campbell DA, Myler PJ. Histone acetylations mark origins of polycistronic transcription in Leishmania major. BMC Genomics. 2009 Apr 08; 10:152. PMID: 19356248.
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    17. Zamudio JR, Mittra B, Chattopadhyay A, Wohlschlegel JA, Sturm NR, Campbell DA. Trypanosoma brucei spliced leader RNA maturation by the cap 1 2'-O-ribose methyltransferase and SLA1 H/ACA snoRNA pseudouridine synthase complex. Mol Cell Biol. 2009 Mar; 29(5):1202-11. PMID: 19103757.
      View in: PubMed
    18. Orlando TC, Mayer MG, Campbell DA, Sturm NR, Floeter-Winter LM. RNA polymerase I promoter and splice acceptor site recognition affect gene expression in non-pathogenic Leishmania species. Mem Inst Oswaldo Cruz. 2007 Nov; 102(7):891-4. PMID: 18060313.
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    19. Mittra B, Zamudio JR, Bujnicki JM, Stepinski J, Darzynkiewicz E, Campbell DA, Sturm NR. The TbMTr1 spliced leader RNA cap 1 2'-O-ribose methyltransferase from Trypanosoma brucei acts with substrate specificity. J Biol Chem. 2008 Feb 08; 283(6):3161-72. PMID: 18048356.
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    20. Zamudio JR, Mittra B, Foldynová-Trantírková S, Zeiner GM, Lukes J, Bujnicki JM, Sturm NR, Campbell DA. The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei. Mol Cell Biol. 2007 Sep; 27(17):6084-92. PMID: 17606627.
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    21. Hitchcock RA, Thomas S, Campbell DA, Sturm NR. The promoter and transcribed regions of the Leishmania tarentolae spliced leader RNA gene array are devoid of nucleosomes. BMC Microbiol. 2007 May 22; 7:44. PMID: 17517143.
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    22. Sturm NR, Dollet M, Lukes J, Campbell DA. Rational sub-division of plant trypanosomes (Phytomonas spp.) based on minicircle conserved region analysis. Infect Genet Evol. 2007 Sep; 7(5):570-6. PMID: 17499027.
      View in: PubMed
    23. Zhang H, Hou Y, Miranda L, Campbell DA, Sturm NR, Gaasterland T, Lin S. Spliced leader RNA trans-splicing in dinoflagellates. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4618-23. PMID: 17360573.
      View in: PubMed
    24. Campbell DA, Sturm NR. The untranslated regions of genes from Trypanosoma cruzi: perspectives for functional characterization of strains and isolates. Mem Inst Oswaldo Cruz. 2007 Feb; 102(1):125-6. PMID: 17294013.
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    25. Maslov DA, Westenberger SJ, Xu X, Campbell DA, Sturm NR. Discovery and barcoding by analysis of spliced leader RNA gene sequences of new isolates of Trypanosomatidae from Heteroptera in Costa Rica and Ecuador. J Eukaryot Microbiol. 2007 Jan-Feb; 54(1):57-65. PMID: 17300521.
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    26. Zamudio JR, Mittra B, Zeiner GM, Feder M, Bujnicki JM, Sturm NR, Campbell DA. Complete cap 4 formation is not required for viability in Trypanosoma brucei. Eukaryot Cell. 2006 Jun; 5(6):905-15. PMID: 16757738.
      View in: PubMed
    27. Thomas S, Yu MC, Sturm NR, Campbell DA. A non-universal transcription factor? The Leishmania tarentolae TATA box-binding protein LtTBP associates with a subset of promoters. Int J Parasitol. 2006 Sep; 36(10-11):1217-26. PMID: 16753168.
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    28. Bhasin KK, Yu JM, Tward A, Shih D, Campbell DA, Lusis AJ. Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006 Nov; 114(3):240-5. PMID: 16682028.
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    29. Westenberger SJ, Cerqueira GC, El-Sayed NM, Zingales B, Campbell DA, Sturm NR. Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region. BMC Genomics. 2006 Mar 22; 7:60. PMID: 16553959.
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    30. Westenberger SJ, Sturm NR, Campbell DA. Trypanosoma cruzi 5S rRNA arrays define five groups and indicate the geographic origins of an ancestor of the heterozygous hybrids. Int J Parasitol. 2006 Mar; 36(3):337-46. PMID: 16443226.
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    31. El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005 Jul 15; 309(5733):409-15. PMID: 16020725.
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    32. Westenberger SJ, Barnabé C, Campbell DA, Sturm NR. Two hybridization events define the population structure of Trypanosoma cruzi. Genetics. 2005 Oct; 171(2):527-43. PMID: 15998728.
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    33. Thomas S, Westenberger SJ, Campbell DA, Sturm NR. Intragenomic spliced leader RNA array analysis of kinetoplastids reveals unexpected transcribed region diversity in Trypanosoma cruzi. Gene. 2005 Jun 06; 352:100-8. PMID: 15925459.
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    34. Foldynová-Trantírková S, Paris Z, Sturm NR, Campbell DA, Lukes J. The Trypanosoma brucei La protein is a candidate poly(U) shield that impacts spliced leader RNA maturation and tRNA intron removal. Int J Parasitol. 2005 Apr 01; 35(4):359-66. PMID: 15777912.
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    35. Zeiner GM, Hitchcock RA, Sturm NR, Campbell DA. 3'-End polishing of the kinetoplastid spliced leader RNA is performed by SNIP, a 3'-->5' exonuclease with a Motley assortment of small RNA substrates. Mol Cell Biol. 2004 Dec; 24(23):10390-6. PMID: 15542846.
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    36. Nóbrega OT, Santana JM, Sturm NR, Teixeira AR, Campbell DA. HygR and PurR plasmid vectors for episomal transfection of Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 2004 Aug; 99(5):513-6. PMID: 15543416.
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    37. Campbell DA, Westenberger SJ, Sturm NR. The determinants of Chagas disease: connecting parasite and host genetics. Curr Mol Med. 2004 Sep; 4(6):549-62. PMID: 15357207.
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    38. Hitchcock RA, Zeiner GM, Sturm NR, Campbell DA. The 3' termini of small RNAs in Trypanosoma brucei. FEMS Microbiol Lett. 2004 Jul 01; 236(1):73-8. PMID: 15212793.
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    39. Podlipaev SA, Sturm NR, Fiala I, Fernandes O, Westenberger SJ, Dollet M, Campbell DA, Lukes J. Diversity of insect trypanosomatids assessed from the spliced leader RNA and 5S rRNA genes and intergenic regions. J Eukaryot Microbiol. 2004 May-Jun; 51(3):283-90. PMID: 15218696.
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    40. Zeiner GM, Foldynová S, Sturm NR, Lukes J, Campbell DA. SmD1 is required for spliced leader RNA biogenesis. Eukaryot Cell. 2004 Feb; 3(1):241-4. PMID: 14871954.
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    41. Campbell DA, Thomas S, Sturm NR. Transcription in kinetoplastid protozoa: why be normal? Microbes Infect. 2003 Nov; 5(13):1231-40. PMID: 14623019.
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    42. Zeiner GM, Sturm NR, Campbell DA. The Leishmania tarentolae spliced leader contains determinants for association with polysomes. J Biol Chem. 2003 Oct 03; 278(40):38269-75. PMID: 12878606.
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    43. Zeiner GM, Sturm NR, Campbell DA. Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA. Eukaryot Cell. 2003 Apr; 2(2):222-30. PMID: 12684371.
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    44. Sturm NR, Vargas NS, Westenberger SJ, Zingales B, Campbell DA. Evidence for multiple hybrid groups in Trypanosoma cruzi. Int J Parasitol. 2003 Mar; 33(3):269-79. PMID: 12670512.
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    45. Yu MC, Orlando TC, Sturm NR, Zhou L, Saito RM, Floeter-Winter LM, Campbell DA. Two distinct functional spliced leader RNA gene arrays in Leishmania tarentolae are found in several lizard Leishmania species. Int J Parasitol. 2002 Oct; 32(11):1411-22. PMID: 12350376.
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    46. Orlando TC, Rubio MA, Sturm NR, Campbell DA, Floeter-Winter LM. Intergenic and external transcribed spacers of ribosomal RNA genes in lizard-infecting Leishmania: molecular structure and phylogenetic relationship to mammal-infecting Leishmania in the subgenus Leishmania (Leishmania). Mem Inst Oswaldo Cruz. 2002 Jul; 97(5):695-701. PMID: 12219138.
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    47. Santana DM, Borja-Cabrera GP, Paraguai de Souza E, Sturm NR, Palatnik de Sousa CB, Campbell DA. Nucleoside hydrolase from Leishmania (L.) donovani is an antigen diagnostic for visceral leishmaniasis. Mol Biochem Parasitol. 2002 Apr 09; 120(2):315-9. PMID: 11897139.
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    48. Campbell DA, Sturm NR, Yu MC. Transcription of the kinetoplastid spliced leader RNA gene. Parasitol Today. 2000 Feb; 16(2):78-82. PMID: 10652494.
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