David A Campbell

Title(s)Professor, MIMG
SchoolMedicine
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    Cap binding and gene expression in trypanosomes
    NIH R03TW009035Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator
    Translational partitioning of the SL RNA
    NIH R21AI073806Jun 1, 2009 - May 31, 2012
    Role: Principal Investigator
    Global sumoylation analysis in Trypanosoma brucei
    NIH R21AI079639May 5, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Kinetoplastid SL RNA Biogenesis
    NIH R01AI056034Jul 1, 2003 - Jun 30, 2015
    Role: Principal Investigator
    EXPRESSION OF THE LEISHMANIA TARENTOLAE SL RNA GENE
    NIH R01AI034536Dec 1, 1994 - Feb 28, 2005
    Role: Principal Investigator
    DNA-BINDING PROTEINS IN TRYPANOSOMA BRUCEI
    NIH R01AI024455Jul 1, 1988 - Jun 30, 1992
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Trypanosoma brucei EIF4E2 cap-binding protein binds a homolog of the histone-mRNA stem-loop-binding protein. Curr Genet. 2018 Aug; 64(4):821-839. Freire ER, Moura DMN, Bezerra MJR, Xavier CC, Morais-Sobral MC, Vashisht AA, Rezende AM, Wohlschlegel JA, Sturm NR, de Melo Neto OP, Campbell DA. PMID: 29288414.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    2. The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. Pathogens. 2017 Oct 27; 6(4). Freire ER, Sturm NR, Campbell DA, de Melo Neto OP. PMID: 29077018; PMCID: PMC5750579.
      View in: PubMed   Mentions: 32  
    3. Spliced leader RNA trans-splicing discovered in copepods. Sci Rep. 2015 Dec 01; 5:17411. Yang F, Xu D, Zhuang Y, Yi X, Huang Y, Chen H, Lin S, Campbell DA, Sturm NR, Liu G, Zhang H. PMID: 26621068; PMCID: PMC4664967.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis. Science. 2015 Nov 06; 350(6261):691-4. Lin S, Cheng S, Song B, Zhong X, Lin X, Li W, Li L, Zhang Y, Zhang H, Ji Z, Cai M, Zhuang Y, Shi X, Lin L, Wang L, Wang Z, Liu X, Yu S, Zeng P, Hao H, Zou Q, Chen C, Li Y, Wang Y, Xu C, Meng S, Xu X, Wang J, Yang H, Campbell DA, Sturm NR, Dagenais-Bellefeuille S, Morse D. PMID: 26542574.
      View in: PubMed   Mentions: 137     Fields:    Translation:Animals
    5. eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei. RNA. 2014 Aug; 20(8):1272-86. Freire ER, Vashisht AA, Malvezzi AM, Zuberek J, Langousis G, Saada EA, Nascimento Jde F, Stepinski J, Darzynkiewicz E, Hill K, De Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. PMID: 24962368; PMCID: PMC4105752.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    6. Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog. Eukaryot Cell. 2014 Jul; 13(7):896-908. Freire ER, Malvezzi AM, Vashisht AA, Zuberek J, Saada EA, Langousis G, Nascimento JD, Moura D, Darzynkiewicz E, Hill K, de Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. PMID: 24839125; PMCID: PMC4135740.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    7. The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genet. 2014 Feb; 10(2):e1004007. Porcel BM, Denoeud F, Opperdoes F, Noel B, Madoui MA, Hammarton TC, Field MC, Da Silva C, Couloux A, Poulain J, Katinka M, Jabbari K, Aury JM, Campbell DA, Cintron R, Dickens NJ, Docampo R, Sturm NR, Koumandou VL, Fabre S, Flegontov P, Lukeš J, Michaeli S, Mottram JC, Szöor B, Zilberstein D, Bringaud F, Wincker P, Dollet M. PMID: 24516393; PMCID: PMC3916237.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    8. Signal recognition particle RNA in dinoflagellates and the Perkinsid Perkinsus marinus. Protist. 2013 Sep; 164(5):748-61. Zhang H, Campbell DA, Sturm NR, Rosenblad MA, Dungan CF, Lin S. PMID: 23994724.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. Infect Genet Evol. 2012 Mar; 12(2):240-53. Zingales B, Miles MA, Campbell DA, Tibayrenc M, Macedo AM, Teixeira MM, Schijman AG, Llewellyn MS, Lages-Silva E, Machado CR, Andrade SG, Sturm NR. PMID: 22226704.
      View in: PubMed   Mentions: 333     Fields:    Translation:HumansAnimals
    10. The internal transcribed spacer of ribosomal RNA genes in plant trypanosomes (Phytomonas spp.) resolves 10 groups. Infect Genet Evol. 2012 Mar; 12(2):299-308. Dollet M, Sturm NR, Campbell DA. PMID: 22155359.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Spliced leader RNAs, mitochondrial gene frameshifts and multi-protein phylogeny expand support for the genus Perkinsus as a unique group of alveolates. PLoS One. 2011; 6(5):e19933. Zhang H, Campbell DA, Sturm NR, Dungan CF, Lin S. PMID: 21629701; PMCID: PMC3101222.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    12. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Nucleic Acids Res. 2011 Jun; 39(11):4756-68. Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM. PMID: 21310715; PMCID: PMC3113572.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    13. Alternative lifestyles: the population structure of Trypanosoma cruzi. Acta Trop. 2010 Jul-Aug; 115(1-2):35-43. Sturm NR, Campbell DA. PMID: 19695212.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    14. Hypermethylated cap 4 maximizes Trypanosoma brucei translation. Mol Microbiol. 2009 Jun; 72(5):1100-10. Zamudio JR, Mittra B, Campbell DA, Sturm NR. PMID: 19504740; PMCID: PMC2859698.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    15. Dinoflagellate spliced leader RNA genes display a variety of sequences and genomic arrangements. Mol Biol Evol. 2009 Aug; 26(8):1757-71. Zhang H, Campbell DA, Sturm NR, Lin S. PMID: 19387009; PMCID: PMC2734150.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    16. Histone acetylations mark origins of polycistronic transcription in Leishmania major. BMC Genomics. 2009 Apr 08; 10:152. Thomas S, Green A, Sturm NR, Campbell DA, Myler PJ. PMID: 19356248; PMCID: PMC2679053.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    17. Trypanosoma brucei spliced leader RNA maturation by the cap 1 2'-O-ribose methyltransferase and SLA1 H/ACA snoRNA pseudouridine synthase complex. Mol Cell Biol. 2009 Mar; 29(5):1202-11. Zamudio JR, Mittra B, Chattopadhyay A, Wohlschlegel JA, Sturm NR, Campbell DA. PMID: 19103757; PMCID: PMC2643836.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    18. RNA polymerase I promoter and splice acceptor site recognition affect gene expression in non-pathogenic Leishmania species. Mem Inst Oswaldo Cruz. 2007 Nov; 102(7):891-4. Orlando TC, Mayer MG, Campbell DA, Sturm NR, Floeter-Winter LM. PMID: 18060313.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. The TbMTr1 spliced leader RNA cap 1 2'-O-ribose methyltransferase from Trypanosoma brucei acts with substrate specificity. J Biol Chem. 2008 Feb 08; 283(6):3161-3172. Mittra B, Zamudio JR, Bujnicki JM, Stepinski J, Darzynkiewicz E, Campbell DA, Sturm NR. PMID: 18048356.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei. Mol Cell Biol. 2007 Sep; 27(17):6084-92. Zamudio JR, Mittra B, Foldynová-Trantírková S, Zeiner GM, Lukes J, Bujnicki JM, Sturm NR, Campbell DA. PMID: 17606627; PMCID: PMC1952150.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. The promoter and transcribed regions of the Leishmania tarentolae spliced leader RNA gene array are devoid of nucleosomes. BMC Microbiol. 2007 May 22; 7:44. Hitchcock RA, Thomas S, Campbell DA, Sturm NR. PMID: 17517143; PMCID: PMC1888695.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Rational sub-division of plant trypanosomes (Phytomonas spp.) based on minicircle conserved region analysis. Infect Genet Evol. 2007 Sep; 7(5):570-6. Sturm NR, Dollet M, Lukes J, Campbell DA. PMID: 17499027.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Spliced leader RNA trans-splicing in dinoflagellates. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4618-23. Zhang H, Hou Y, Miranda L, Campbell DA, Sturm NR, Gaasterland T, Lin S. PMID: 17360573; PMCID: PMC1838650.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    24. The untranslated regions of genes from Trypanosoma cruzi: perspectives for functional characterization of strains and isolates. Mem Inst Oswaldo Cruz. 2007 Feb; 102(1):125-6. Campbell DA, Sturm NR. PMID: 17294013.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    25. Discovery and barcoding by analysis of spliced leader RNA gene sequences of new isolates of Trypanosomatidae from Heteroptera in Costa Rica and Ecuador. J Eukaryot Microbiol. 2007 Jan-Feb; 54(1):57-65. Maslov DA, Westenberger SJ, Xu X, Campbell DA, Sturm NR. PMID: 17300521.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    26. Complete cap 4 formation is not required for viability in Trypanosoma brucei. Eukaryot Cell. 2006 Jun; 5(6):905-15. Zamudio JR, Mittra B, Zeiner GM, Feder M, Bujnicki JM, Sturm NR, Campbell DA. PMID: 16757738; PMCID: PMC1489268.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    27. A non-universal transcription factor? The Leishmania tarentolae TATA box-binding protein LtTBP associates with a subset of promoters. Int J Parasitol. 2006 Sep; 36(10-11):1217-26. Thomas S, Yu MC, Sturm NR, Campbell DA. PMID: 16753168.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    28. Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006 Nov; 114(3):240-5. Bhasin KK, Yu JM, Tward A, Shih D, Campbell DA, Lusis AJ. PMID: 16682028.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    29. Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region. BMC Genomics. 2006 Mar 22; 7:60. Westenberger SJ, Cerqueira GC, El-Sayed NM, Zingales B, Campbell DA, Sturm NR. PMID: 16553959; PMCID: PMC1559615.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    30. Trypanosoma cruzi 5S rRNA arrays define five groups and indicate the geographic origins of an ancestor of the heterozygous hybrids. Int J Parasitol. 2006 Mar; 36(3):337-46. Westenberger SJ, Sturm NR, Campbell DA. PMID: 16443226.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    31. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005 Jul 15; 309(5733):409-15. El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B. PMID: 16020725.
      View in: PubMed   Mentions: 563     Fields:    Translation:HumansAnimalsCells
    32. Two hybridization events define the population structure of Trypanosoma cruzi. Genetics. 2005 Oct; 171(2):527-43. Westenberger SJ, Barnabé C, Campbell DA, Sturm NR. PMID: 15998728; PMCID: PMC1456769.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    33. Intragenomic spliced leader RNA array analysis of kinetoplastids reveals unexpected transcribed region diversity in Trypanosoma cruzi. Gene. 2005 Jun 06; 352:100-8. Thomas S, Westenberger SJ, Campbell DA, Sturm NR. PMID: 15925459.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. The Trypanosoma brucei La protein is a candidate poly(U) shield that impacts spliced leader RNA maturation and tRNA intron removal. Int J Parasitol. 2005 Apr 01; 35(4):359-66. Foldynová-Trantírková S, Paris Z, Sturm NR, Campbell DA, Lukes J. PMID: 15777912.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. 3'-End polishing of the kinetoplastid spliced leader RNA is performed by SNIP, a 3'-->5' exonuclease with a Motley assortment of small RNA substrates. Mol Cell Biol. 2004 Dec; 24(23):10390-6. Zeiner GM, Hitchcock RA, Sturm NR, Campbell DA. PMID: 15542846; PMCID: PMC529039.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. HygR and PurR plasmid vectors for episomal transfection of Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 2004 Aug; 99(5):513-6. Nóbrega OT, Santana JM, Sturm NR, Teixeira AR, Campbell DA. PMID: 15543416.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    37. The determinants of Chagas disease: connecting parasite and host genetics. Curr Mol Med. 2004 Sep; 4(6):549-62. Campbell DA, Westenberger SJ, Sturm NR. PMID: 15357207.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    38. The 3' termini of small RNAs in Trypanosoma brucei. FEMS Microbiol Lett. 2004 Jul 01; 236(1):73-8. Hitchcock RA, Zeiner GM, Sturm NR, Campbell DA. PMID: 15212793.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    39. Diversity of insect trypanosomatids assessed from the spliced leader RNA and 5S rRNA genes and intergenic regions. J Eukaryot Microbiol. 2004 May-Jun; 51(3):283-90. Podlipaev SA, Sturm NR, Fiala I, Fernandes O, Westenberger SJ, Dollet M, Campbell DA, Lukes J. PMID: 15218696.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    40. SmD1 is required for spliced leader RNA biogenesis. Eukaryot Cell. 2004 Feb; 3(1):241-4. Zeiner GM, Foldynová S, Sturm NR, Lukes J, Campbell DA. PMID: 14871954; PMCID: PMC329508.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    41. Transcription in kinetoplastid protozoa: why be normal? Microbes Infect. 2003 Nov; 5(13):1231-40. Campbell DA, Thomas S, Sturm NR. PMID: 14623019.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    42. The Leishmania tarentolae spliced leader contains determinants for association with polysomes. J Biol Chem. 2003 Oct 03; 278(40):38269-75. Zeiner GM, Sturm NR, Campbell DA. PMID: 12878606.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    43. Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA. Eukaryot Cell. 2003 Apr; 2(2):222-30. Zeiner GM, Sturm NR, Campbell DA. PMID: 12684371; PMCID: PMC154853.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    44. Evidence for multiple hybrid groups in Trypanosoma cruzi. Int J Parasitol. 2003 Mar; 33(3):269-79. Sturm NR, Vargas NS, Westenberger SJ, Zingales B, Campbell DA. PMID: 12670512.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    45. Intergenic and external transcribed spacers of ribosomal RNA genes in lizard-infecting Leishmania: molecular structure and phylogenetic relationship to mammal-infecting Leishmania in the subgenus Leishmania (Leishmania). Mem Inst Oswaldo Cruz. 2002 Jul; 97(5):695-701. Orlando TC, Rubio MA, Sturm NR, Campbell DA, Floeter-Winter LM. PMID: 12219138.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Nucleoside hydrolase from Leishmania (L.) donovani is an antigen diagnostic for visceral leishmaniasis. Mol Biochem Parasitol. 2002 Apr 09; 120(2):315-9. Santana DM, Borja-Cabrera GP, Paraguai de Souza E, Sturm NR, Palatnik de Sousa CB, Campbell DA. PMID: 11897139.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    47. Transcription of the kinetoplastid spliced leader RNA gene. Parasitol Today. 2000 Feb; 16(2):78-82. Campbell DA, Sturm NR, Yu MC. PMID: 10652494.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
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