David Wayne Dawson

Title(s)Professor Of Clinical, Pathology and Laboratory Medicine
SchoolMedicine
ORCID ORCID Icon0000-0002-0215-5861 Additional info
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    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NCBS05/1991Zoology
    Northwestern University, Chicago, ILMD, PhD06/1999
    University of California, Los Angeles, Los Angeles, CA06/2002Anatomic Pathology, Gastrointestinal Pathology

    Collapse Research 
    Collapse research activities and funding
    UCLA-Caltech Medical Scientist Training Program
    NIH T32GM152342Jul 1, 2024 - Jun 30, 2029
    Role: Principal Investigator
    UCLA-Caltech Medical Scientist Training Program
    NIH T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neoadjuvant modified FOLFIRINOX plus nivolumab in borderline-resectable pancreatic ductal adenocarcinoma: a pilot phase 1 trial. Nat Commun. 2026 Jan 31; 17(1). Wainberg ZA, Link JM, Premji A, Zheng S, Srienc M, Hammons M, Kim SE, Li L, Liu Z, Tsvetkova O, Abt ER, Rosen L, Kim S, King J, Hines OJ, Girgis M, Sadeghi S, Olevsky O, Wong D, Yonemoto L, Siney AM, Kelly K, Kivork C, Tseng CH, Radu CG, Dawson DW, Donahue TR. PMID: 41620440; PMCID: PMC12963377.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    2. Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug. Proc Natl Acad Sci U S A. 2026 Jan 27; 123(4):e2511733123. Antonucci L, Watari K, Feng Y, Qi J, Zhu M, Wang T, Ng I, Vucic EA, Riahi I, Huang L, Hosseini M, Mose E, French R, Weitz J, Bar-Sagi D, Dawson DW, Sun B, Tiriac H, Xu J, Xu S, Lowy AM, Karin M. PMID: 41564125; PMCID: PMC12849708.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis. J Clin Invest. 2025 11 17; 135(22). Clausen TM, Weiss RJ, Tremblay JR, Kellman BP, Coker J, Dworkin LA, Rodriguez JP, Chang IM, Chen T, Padala V, Karlsson R, Song H, Peck KL, Ogawa S, Sandoval DR, Joshi HJ, Wang G, Ferguson LP, Bhalerao N, Moores A, Reya T, Sander M, Caffrey TC, Grem JL, Aicher A, Heeschen C, Le D, Lewis NE, Hollingsworth MA, Grandgenett PM, Bellis SL, Miller RL, Fuster MM, Dawson DW, Engle DD, Esko JD. PMID: 40924474; PMCID: PMC12618072.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. Nat Cancer. 2025 Jul; 6(7):1263-1282. Antonucci L, Li N, Duran A, Cobo I, Nicoletti C, Watari K, Nandi SP, Zhu F, Zhao Y, Riahi I, Tsuda M, Shah VM, Morgan T, Waugh T, Caputo L, Liu Y, Rundberg Nilsson A, Xian H, Todoric J, Gu L, Sanchez-Lopez E, Eibl G, Vucic EA, Krawczyk M, Xu Q, Lowy AM, Hatzivassiliou G, Roose-Girma M, Skowronska-Krawczyk D, Scott DA, Bar-Sagi D, Tamayo P, Wu Y, Sears RC, Glass CK, Alexandrov LB, Puri PL, Dawson DW, Hu Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 40588523; PMCID: PMC12331375.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Emerin is an effector of oncogenic KRAS-driven nuclear dynamics in pancreatic cancer. JCI Insight. 2025 Jul 22; 10(14). Flores LF, Marks DL, Vera RE, Sigafoos AN, Tolosa EJ, Almada LL, Pease DR, Toruner MD, Chang B, Tader BR, LaRue-Nolan KC, Carr RM, Graham RP, Hagen CE, Brown MR, Matveyenko AV, Wilson KL, Dawson DW, Pin CL, Roux KJ, Fernandez-Zapico ME. PMID: 40493403; PMCID: PMC12288966.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins. Science. 2025 03 28; 387(6741):eadq8331. Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. PMID: 40146846; PMCID: PMC12832182.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Cell polarity proteins promote macropinocytosis in response to metabolic stress. Nat Commun. 2024 12 03; 15(1):10541. Lambies G, Lee SW, Duong-Polk K, Aza-Blanc P, Maganti S, Galapate CM, Deshpande A, Deshpande AJ, Scott DA, Dawson DW, Commisso C. PMID: 39627191; PMCID: PMC11614886.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature. Clin J Gastroenterol. 2024 Dec; 17(6):1003-1008. Moffatt C, Soriano C, Dawson DW, Weiss GA. PMID: 39261360.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Oncogenic pathway signatures predict the risk of progression and recurrence in well-differentiated pancreatic neuroendocrine tumors. J Surg Oncol. 2024 Oct; 130(5):1070-1077. Mederos MA, Court CM, Dipardo BJ, Pisegna JR, Dawson DW, Joe Hines O, Donahue TR, Graeber TG, Girgis MD, Tomlinson JS. PMID: 39155697; PMCID: PMC11654900.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness. Gastro Hep Adv. 2024; 3(5):687-702. Hatziapostolou M, Koutsioumpa M, Zaitoun AM, Polytarchou C, Edderkaoui M, Mahurkar-Joshi S, Vadakekolathu J, D'Andrea D, Lay AR, Christodoulou N, Pham T, Yau TO, Vorvis C, Chatterji S, Pandol SJ, Poultsides GA, Dawson DW, Lobo DN, Iliopoulos D. PMID: 39165427; PMCID: PMC11330932.
      View in: PubMed   Mentions: 4  
    11. Fibroblast Activation Protein Expression in Sarcomas. Sarcoma. 2023; 2023:2480493. Crane JN, Graham DS, Mona CE, Nelson SD, Samiei A, Dawson DW, Dry SM, Masri MG, Crompton JG, Benz MR, Czernin J, Eilber FC, Graeber TG, Calais J, Federman NC. PMID: 37333052; PMCID: PMC10275689.
      View in: PubMed   Mentions: 20  
    12. FAPI PET Signal in Hibernoma Reflects FAP Expression in Tumor Vasculature Cells. Clin Nucl Med. 2023 Jul 01; 48(7):e353-e355. Hotta M, Mona CE, Crompton JG, Armstrong WR, Gafita A, Nelson SD, Eilber FC, Dawson DW, Calais J, Benz MR. PMID: 37146173.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Construction of a radiogenomic association map of pancreatic ductal adenocarcinoma. BMC Cancer. 2023 Feb 27; 23(1):189. Jamshidi N, Senthilvelan J, Dawson DW, Donahue TR, Kuo MD. PMID: 36843111; PMCID: PMC9969670.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Proteomes of Extracellular Vesicles From Pancreatic Cancer Cells and Cancer-Associated Fibroblasts. Pancreas. 2022 08 01; 51(7):790-799. Pan S, Lai LA, Simeone DM, Dawson DW, Yan Y, Crnogorac-Jurcevic T, Chen R, Brentnall TA. PMID: 36395405; PMCID: PMC9678144.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade. Cell Mol Life Sci. 2022 Jun 14; 79(7):362. Kirtonia A, Pandey AK, Ramachandran B, Mishra DP, Dawson DW, Sethi G, Ganesan TS, Koeffler HP, Garg M. PMID: 35699794; PMCID: PMC11073089.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    16. Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer. Mol Cancer Ther. 2022 06 01; 21(6):936-947. Aguilera KY, Le T, Riahi R, Lay AR, Hinz S, Saadat EA, Vashisht AA, Wohlschlegel J, Donahue TR, Radu CG, Dawson DW. PMID: 35313331; PMCID: PMC9167706.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells. Cell Rep. 2022 01 11; 38(2):110236. Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. PMID: 35021095; PMCID: PMC8893345.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    18. Correlation of 68Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study. J Nucl Med. 2022 07; 63(7):1021-1026. Mona CE, Benz MR, Hikmat F, Grogan TR, Lueckerath K, Razmaria A, Riahi R, Slavik R, Girgis MD, Carlucci G, Kelly KA, French SW, Czernin J, Dawson DW, Calais J. PMID: 34740953; PMCID: PMC9258565.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCTClinical Trials
    19. Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts. Cancer Discov. 2022 02; 12(2):484-501. Helms EJ, Berry MW, Chaw RC, DuFort CC, Sun D, Onate MK, Oon C, Bhattacharyya S, Sanford-Crane H, Horton W, Finan JM, Sattler A, Makar R, Dawson DW, Xia Z, Hingorani SR, Sherman MH. PMID: 34548310; PMCID: PMC8831457.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    20. Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis. J Clin Invest. 2021 08 02; 131(15). Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS. PMID: 34128834; PMCID: PMC8321573.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Proteome heterogeneity and malignancy detection in pancreatic cyst fluids. Clin Transl Med. 2021 08; 11(8):e506. Pan S, Brand RE, Lai LA, Dawson DW, Donahue TR, Kim S, Khalaf NI, Othman MO, Fisher WE, Bronner MP, Simeone DM, Brentnall TA, Chen R. PMID: 34459141; PMCID: PMC8382978.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Intestinal mucormycosis initially identified by next-generation sequencing of cell-free DNA. Transpl Infect Dis. 2021 Aug; 23(4):e13656. Martin-Blais R, Pathak S, Fitzwater S, Dawson DW, Sisk AE, Farmer DG, Venick R, Yeganeh N. PMID: 34176206.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. WNT Ligand Dependencies in Pancreatic Cancer. Front Cell Dev Biol. 2021; 9:671022. Aguilera KY, Dawson DW. PMID: 33996827; PMCID: PMC8113755.
      View in: PubMed   Mentions: 40  
    24. Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. Nat Cell Biol. 2021 03; 23(3):232-242. Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM. PMID: 33686253; PMCID: PMC9446896.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    25. NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Moore AM, Zhou L, Cui J, Li L, Wu N, Yu A, Poddar S, Liang K, Abt ER, Kim S, Ghukasyan R, Khachatourian N, Pagano K, Elliott I, Dann AM, Riahi R, Le T, Dawson DW, Radu CG, Donahue TR. PMID: 33597293; PMCID: PMC7923374.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    26. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb; 181:25-33. Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. PMID: 33242496; PMCID: PMC7863625.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity. Clin Cancer Res. 2020 06 15; 26(12):2946-2955. Current K, Meyer C, Magyar CE, Mona CE, Almajano J, Slavik R, Stuparu AD, Cheng C, Dawson DW, Radu CG, Czernin J, Lueckerath K. PMID: 31932492; PMCID: PMC7299755.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    28. Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. Theranostics. 2020; 10(2):829-840. Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. PMID: 31903153; PMCID: PMC6929997.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. A Prognostic Scoring System for the Prediction of Metastatic Recurrence Following Curative Resection of Pancreatic Neuroendocrine Tumors. J Gastrointest Surg. 2019 07; 23(7):1392-1400. Sho S, Court CM, Winograd P, Toste PA, Pisegna JR, Lewis M, Donahue TR, Hines OJ, Reber HA, Dawson DW, Tomlinson JS. PMID: 30353489; PMCID: PMC6736531.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    30. Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Gut. 2019 07; 68(7):1271-1286. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernández-Zapico ME, Iliopoulos D. PMID: 30337373; PMCID: PMC6697184.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    31. KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs. Sci Rep. 2018 08 22; 8(1):12548. Principe DR, Overgaard NH, Park AJ, Diaz AM, Torres C, McKinney R, Dorman MJ, Castellanos K, Schwind R, Dawson DW, Rana A, Maker A, Munshi HG, Rund LA, Grippo PJ, Schook LB. PMID: 30135483; PMCID: PMC6105629.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    32. Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. Sci Rep. 2018 04 12; 8(1):5899. Chang HH, Moro A, Chou CEN, Dawson DW, French S, Schmidt AI, Sinnett-Smith J, Hao F, Hines OJ, Eibl G, Rozengurt E. PMID: 29651002; PMCID: PMC5897574.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    33. Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. Oncotarget. 2017 Nov 03; 8(54):92667-92681. Schultz MA, Diaz AM, Smite S, Lay AR, DeCant B, McKinney R, Mascarinas WE, Xia Y, Neumann C, Bentrem D, Dawson DW, Grippo PJ. PMID: 29190947; PMCID: PMC5696213.
      View in: PubMed   Mentions: 6     Fields:    
    34. Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One. 2017; 12(9):e0184455. Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G. PMID: 28886117; PMCID: PMC5590955.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    35. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017 Jul 06; 2(13). Schludi B, Moin ASM, Montemurro C, Gurlo T, Matveyenko AV, Kirakossian D, Dawson DW, Dry SM, Butler PC, Butler AE. PMID: 28679961; PMCID: PMC5499368.
      View in: PubMed   Mentions: 16     Fields:    
    36. The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis. Cell Rep. 2017 05 16; 19(7):1322-1333. Liou GY, Bastea L, Fleming A, Döppler H, Edenfield BH, Dawson DW, Zhang L, Bardeesy N, Storz P. PMID: 28514653; PMCID: PMC5510483.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    37. Preoperative Treatment With FOLFIRINOX and Successful Resection for a Patient With Mixed Acinar-Endocrine Carcinoma of the Pancreas. Pancreas. 2017 Apr; 46(4):e32-e34. Sugimoto M, Hines OJ, Dawson DW, Muthusamy VR, Reber HA, Donahue TR. PMID: 28291165; PMCID: PMC5354082.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts. Oncotarget. 2017 Mar 21; 8(12):19074-19088. Nguyen AH, Elliott IA, Wu N, Matsumura C, Vogelauer M, Attar N, Dann A, Ghukasyan R, Toste PA, Patel SG, Williams JL, Li L, Dawson DW, Radu C, Kurdistani SK, Donahue TR. PMID: 27894105; PMCID: PMC5386671.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    39. Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. Surgery. 2017 06; 161(6):1570-1578. Schmidt A, Sinnett-Smith J, Young S, Chang HH, Hines OJ, Dawson DW, Rozengurt E, Eibl G. PMID: 28222855; PMCID: PMC5433907.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Assessment of a Revised Management Strategy for Patients With Intraductal Papillary Mucinous Neoplasms Involving the Main Pancreatic Duct. JAMA Surg. 2017 01 18; 152(1):e163349. Sugimoto M, Elliott IA, Nguyen AH, Kim S, Muthusamy VR, Watson R, Hines OJ, Dawson DW, Reber HA, Donahue TR. PMID: 27829085.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    41. Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation. Oncotarget. 2017 Jan 17; 8(3):3826-3839. Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne EA, Mascariñas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B. PMID: 27270652; PMCID: PMC5354798.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    42. Association of Histopathologic Phenotype of Periampullary Adenocarcinomas With Survival. JAMA Surg. 2017 01 01; 152(1):82-88. Williams JL, Chan CK, Toste PA, Elliott IA, Vasquez CR, Sunjaya DB, Swanson EA, Koo J, Hines OJ, Reber HA, Dawson DW, Donahue TR. PMID: 27732711.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    43. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev. 2016 12 15; 30(24):2669-2683. Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. PMID: 28087712; PMCID: PMC5238727.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    44. Plectin-1 as a Biomarker of Malignant Progression in Intraductal Papillary Mucinous Neoplasms: A Multicenter Study. Pancreas. 2016 10; 45(9):1353-8. Moris M, Dawson DW, Jiang J, Lewis J, Nassar A, Takeuchi KK, Lay AR, Zhai Q, Donahue TR, Kelly KA, Crawford HC, Wallace M. PMID: 27101571; PMCID: PMC5021548.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    45. Allograft biopsy findings in patients with small bowel transplantation. Clin Transplant. 2016 11; 30(11):1433-1439. Koo J, Dawson DW, Dry S, French SW, Naini BV, Wang HL. PMID: 27582272.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    46. Leveraging Mechanisms Governing Pancreatic Tumorigenesis To Reduce Pancreatic Cancer Mortality. Trends Endocrinol Metab. 2016 11; 27(11):770-781. Donahue TR, Dawson DW. PMID: 27461042; PMCID: PMC5075262.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    47. Gemcitabine Activates Natural Killer Cells to Attenuate Pancreatic Cancer Recurrence. Gastroenterology. 2016 08; 151(2):234-7. Dawson DW, Fernandez-Zapico ME. PMID: 27374366; PMCID: PMC6042851.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    48. Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK. Mol Cancer Res. 2016 05; 14(5):437-47. Toste PA, Nguyen AH, Kadera BE, Duong M, Wu N, Gawlas I, Tran LM, Bikhchandani M, Li L, Patel SG, Dawson DW, Donahue TR. PMID: 26979711; PMCID: PMC4867256.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    49. TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis. Cancer Res. 2016 05 01; 76(9):2525-39. Principe DR, DeCant B, Mascariñas E, Wayne EA, Diaz AM, Akagi N, Hwang R, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ. PMID: 26980767; PMCID: PMC4873388.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    50. Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas. 2016 Mar; 45(3):458-65. Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G. PMID: 26495779; PMCID: PMC4854638.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    51. Long-term survival in patients with pancreatic ductal adenocarcinoma. Surgery. 2016 06; 159(6):1520-1527. Stark AP, Sacks GD, Rochefort MM, Donahue TR, Reber HA, Tomlinson JS, Dawson DW, Eibl G, Hines OJ. PMID: 26847803; PMCID: PMC4856542.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    52. Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease. J Surg Oncol. 2015 Sep; 112(4):396-402. Williams JL, Nguyen AH, Rochefort M, Muthusamy VR, Wainberg ZA, Dawson DW, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. PMID: 26303811.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    53. Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Mol Cancer Res. 2015 Nov; 13(11):1509-19. Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. PMID: 26224368; PMCID: PMC4644680.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    54. Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes. PLoS One. 2015; 10(6):e0128814. Thompson MJ, Rubbi L, Dawson DW, Donahue TR, Pellegrini M. PMID: 26039411; PMCID: PMC4454596.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    55. Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation. Genes Dev. 2015 Mar 15; 29(6):658-71. Roy N, Malik S, Villanueva KE, Urano A, Lu X, Von Figura G, Seeley ES, Dawson DW, Collisson EA, Hebrok M. PMID: 25792600; PMCID: PMC4378197.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    56. p85α is a microRNA target and affects chemosensitivity in pancreatic cancer. J Surg Res. 2015 Jun 15; 196(2):285-293. Toste PA, Li L, Kadera BE, Nguyen AH, Tran LM, Wu N, Madnick DL, Patel SG, Dawson DW, Donahue TR. PMID: 25846727; PMCID: PMC4442711.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    57. Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions. Cancer Discov. 2015 Jan; 5(1):52-63. Liou GY, Döppler H, Necela B, Edenfield B, Zhang L, Dawson DW, Storz P. PMID: 25361845; PMCID: PMC4293204.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    58. Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma. Lab Invest. 2015 Jan; 95(1):43-55. Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA. PMID: 25347153; PMCID: PMC4281293.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    59. Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and is targeted by epidermal growth factor receptor inhibition. Clin Cancer Res. 2015 Jan 01; 21(1):157-65. Kadera BE, Toste PA, Wu N, Li L, Nguyen AH, Dawson DW, Donahue TR. PMID: 25348515; PMCID: PMC4286535.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    60. Mucinous cystic neoplasms of the pancreas: are we overestimating malignant potential? Am Surg. 2014 Oct; 80(10):915-9. Nguyen D, Dawson DW, Hines OJ, Reber HA, Donahue TR. PMID: 25264629.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    61. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922; PMCID: PMC4177038.
      View in: PubMed   Mentions: 643     Fields:    Translation:HumansAnimalsCells
    62. The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth. Mol Cancer Ther. 2014 Oct; 13(10):2303-14. Arensman MD, Telesca D, Lay AR, Kershaw KM, Wu N, Donahue TR, Dawson DW. PMID: 25082960; PMCID: PMC4188417.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    63. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014 Mar; 16(3):255-67. von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. PMID: 24561622; PMCID: PMC4684081.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    64. Locally advanced pancreatic cancer: association between prolonged preoperative treatment and lymph-node negativity and overall survival. JAMA Surg. 2014 Feb; 149(2):145-53. Kadera BE, Sunjaya DB, Isacoff WH, Li L, Hines OJ, Tomlinson JS, Dawson DW, Rochefort MM, Donald GW, Clerkin BM, Reber HA, Donahue TR. PMID: 24306217.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    65. Nonfunctional pancreatic neuroendocrine tumors <2 cm on preoperative imaging are associated with a low incidence of nodal metastasis and an excellent overall survival. J Gastrointest Surg. 2013 Dec; 17(12):2105-13. Toste PA, Kadera BE, Tatishchev SF, Dawson DW, Clerkin BM, Muthusamy R, Watson R, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. PMID: 24101447.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    66. Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604. Diabetes. 2013 Oct; 62(10):e19-22. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. PMID: 24065800; PMCID: PMC3781463.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    67. MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. PLoS One. 2013; 8(8):e71978. Kadera BE, Li L, Toste PA, Wu N, Adams C, Dawson DW, Donahue TR. PMID: 23991015; PMCID: PMC3750050.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    68. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct; 6(10):1064-73. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. PMID: 23943783; PMCID: PMC3835151.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    69. Notch1 activation up-regulates pancreatic and duodenal homeobox-1. Genes (Basel). 2013 Jul 19; 4(3):358-74. Liu SH, Zhou G, Yu J, Wu J, Nemunaitis J, Senzer N, Dawson D, Li M, Fisher WE, Brunicardi FC. PMID: 24705209; PMCID: PMC3924823.
      View in: PubMed   Mentions: 3     Fields:    
    70. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 2013 Jul; 62(7):2595-604. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. PMID: 23524641; PMCID: PMC3712065.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansCells
    71. HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma. Cancer. 2013 Feb 01; 119(3):529-39. Nguyen Kovochich A, Arensman M, Lay AR, Rao NP, Donahue T, Li X, French SW, Dawson DW. PMID: 22914903; PMCID: PMC3867310.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    72. Integrative survival-based molecular profiling of human pancreatic cancer. Clin Cancer Res. 2012 Mar 01; 18(5):1352-63. Donahue TR, Tran LM, Hill R, Li Y, Kovochich A, Calvopina JH, Patel SG, Wu N, Hindoyan A, Farrell JJ, Li X, Dawson DW, Wu H. PMID: 22261810; PMCID: PMC3816537.
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    73. Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology. 2012 Feb; 142(2):219-32. White BD, Chien AJ, Dawson DW. PMID: 22155636; PMCID: PMC3285553.
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    74. Nodal/Activin signaling: a novel target for pancreatic cancer stem cell therapy. Cell Stem Cell. 2011 Nov 04; 9(5):383-4. Donahue TR, Dawson DW. PMID: 22056131.
      View in: PubMed   Mentions: 3     Fields:    
    75. Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. Pancreas. 2011 Apr; 40(3):453-9. Takahashi H, Li A, Dawson DW, Hines OJ, Reber HA, Eibl G. PMID: 21343834; PMCID: PMC3077942.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    76. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. Am J Pathol. 2011 Mar; 178(3):1340-9. Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ. PMID: 21356384; PMCID: PMC3069811.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    77. N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery. 2011 May; 149(5):614-24. Angst E, Dawson DW, Stroka D, Gloor B, Park J, Candinas D, Reber HA, Hines OJ, Eibl G. PMID: 21236457.
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    78. PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res. 2010 Sep 15; 70(18):7114-24. Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H. PMID: 20807812; PMCID: PMC2940963.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    79. Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas. 2010 Jul; 39(5):675-9. Angst E, Dawson DW, Nguyen A, Park J, Go VL, Reber HA, Hines OJ, Eibl G. PMID: 20173668; PMCID: PMC2895953.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    80. Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. J Agric Food Chem. 2010 Jun 23; 58(12):7252-7. Zhang L, Angst E, Park JL, Moro A, Dawson DW, Reber HA, Eibl G, Hines OJ, Go VL, Lu QY. PMID: 20499918; PMCID: PMC2894579.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    81. Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. Pancreas. 2010 Apr; 39(3):332-9. Pham H, Chen M, Li A, King J, Angst E, Dawson DW, Park J, Reber HA, Hines OJ, Eibl G. PMID: 19820419; PMCID: PMC2859226.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    82. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol. 2010 Mar 10; 28(8):1358-65. Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, Kurdistani SK, Guha C, Dawson DW. PMID: 20142597; PMCID: PMC2834495.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    83. Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress. Am J Pathol. 2009 Oct; 175(4):1653-61. Balatoni CE, Dawson DW, Suh J, Sherman MH, Sanders G, Hong JS, Frank MJ, Malone CS, Said JW, Teitell MA. PMID: 19717643; PMCID: PMC2751561.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    84. Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13433-8. Chen SS, Raval A, Johnson AJ, Hertlein E, Liu TH, Jin VX, Sherman MH, Liu SJ, Dawson DW, Williams KE, Lanasa M, Liyanarachchi S, Lin TS, Marcucci G, Pekarsky Y, Davuluri R, Croce CM, Guttridge DC, Teitell MA, Byrd JC, Plass C. PMID: 19666576; PMCID: PMC2726368.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    85. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 2009 Mar 12; 113(11):2478-87. Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA. PMID: 19147787; PMCID: PMC2656273.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    86. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas. 2008 Aug; 37(2):121-7. Hasan S, Satake M, Dawson DW, Funahashi H, Angst E, Go VL, Reber HA, Hines OJ, Eibl G. PMID: 18665070.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    87. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2008 Jul; 6(7):815-9; quiz 719. Tang RS, Weinberg B, Dawson DW, Reber H, Hines OJ, Tomlinson JS, Chaudhari V, Raman S, Farrell JJ. PMID: 18602036.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    88. Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Mol Cell Biol. 2006 Nov; 26(22):8475-87. Chen HW, Rainey RN, Balatoni CE, Dawson DW, Troke JJ, Wasiak S, Hong JS, McBride HM, Koehler CM, Teitell MA, French SW. PMID: 16966381; PMCID: PMC1636764.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    89. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. Cancer Lett. 2007 Apr 18; 248(2):198-210. French SW, Dawson DW, Chen HW, Rainey RN, Sievers SA, Balatoni CE, Wong L, Troke JJ, Nguyen MT, Koehler CM, Teitell MA. PMID: 16934922.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    90. T cell leukemia-1 modulates TCR signal strength and IFN-gamma levels through phosphatidylinositol 3-kinase and protein kinase C pathway activation. J Immunol. 2005 Jul 15; 175(2):864-73. Hoyer KK, Herling M, Bagrintseva K, Dawson DW, French SW, Renard M, Weinger JG, Jones D, Teitell MA. PMID: 16002684.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    91. Virilization in bilateral macronodular adrenal hyperplasia controlled by luteinizing hormone. J Clin Endocrinol Metab. 2003 Jan; 88(1):73-7. Goodarzi MO, Dawson DW, Li X, Lei Z, Shintaku P, Rao CV, Van Herle AJ. PMID: 12519832.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    92. DNA methylation profiling: a new tool for evaluating hematologic malignancies. Clin Immunol. 2002 Jun; 103(3 Pt 1):217-30. French SW, Dawson DW, Miner MD, Doerr JR, Malone CS, Wall R, Teitell MA. PMID: 12173296.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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