Debora B Farber

Title(s)Professor, Ophthalmology
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    Collapse Research 
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    Stem Cell Microvesicles: Potential Tools for Retinal Regeneration
    NIH R21EY018739Dec 1, 2007 - Nov 30, 2009
    Role: Principal Investigator
    Transgenic/Molecular Approaches for Ocular Albinism
    NIH R01EY015141Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Pathfinding of Ganglion Cell Axons and Ocular Albinism
    NIH R03EY013739Aug 1, 2001 - Jul 31, 2004
    Role: Principal Investigator
    Molecular Mechanisms in Retinal Degeneration
    NIH R01EY008285Aug 1, 1989 - Nov 30, 2012
    Role: Principal Investigator
    NIH R01EY002651Aug 1, 1978 - Jul 31, 2006
    Role: Principal Investigator
    NIH R37EY002651Aug 1, 1978 - Jul 31, 1999
    Role: Principal Investigator
    Vision Science Training Program
    NIH T32EY007026Jul 1, 1975 - Aug 31, 2022
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Generation of a human Ocular Albinism type 1 iPSC line, SEIi001-A, with a mutation in GPR143. Stem Cell Res. 2018 12; 33:274-277. Baulier E, Garcia Diaz A, Corneo B, Farber DB. PMID: 30513407.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Human embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells. PLoS One. 2018; 13(3):e0194004. Peng Y, Baulier E, Ke Y, Young A, Ahmedli NB, Schwartz SD, Farber DB. PMID: 29538408.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism. PLoS One. 2016; 11(9):e0162273. Young A, Dandekar U, Pan C, Sader A, Zheng JJ, Lewis RA, Farber DB. PMID: 27607449.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Embryonic Stem Cell-Derived Microvesicles: Could They be Used for Retinal Regeneration? Adv Exp Med Biol. 2016; 854:563-9. Farber DB, Katsman D. PMID: 26427460.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. A constitutively active Gai3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1-/- mice. PLoS One. 2013; 8(9):e76240. Young A, Wang Y, Ahmedli NB, Jiang M, Farber DB. PMID: 24098784.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. J Biol Chem. 2013 Apr 05; 288(14):9742-9754. Ahmedli NB, Gribanova Y, Njoku CC, Naidu A, Young A, Mendoza E, Yamashita CK, Özgül RK, Johnson JE, Fox DA, Farber DB. PMID: 23386608.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Embryonic stem cell-derived microvesicles induce gene expression changes in Müller cells of the retina. PLoS One. 2012; 7(11):e50417. Katsman D, Stackpole EJ, Domin DR, Farber DB. PMID: 23226281.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    8. Molecular diagnosis of putative Stargardt Disease probands by exome sequencing. BMC Med Genet. 2012 Aug 03; 13:67. Strom SP, Gao YQ, Martinez A, Ortube C, Chen Z, Nelson SF, Nusinowitz S, Farber DB, Gorin MB. PMID: 22863181.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    9. Sequence-specific binding of recombinant Zbed4 to DNA: insights into Zbed4 participation in gene transcription and its association with other proteins. PLoS One. 2012; 7(5):e35317. Mokhonov VV, Theendakara VP, Gribanova YE, Ahmedli NB, Farber DB. PMID: 22693546.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. Specific interaction of Gai3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium. PLoS One. 2011; 6(9):e24376. Young A, Jiang M, Wang Y, Ahmedli NB, Ramirez J, Reese BE, Birnbaumer L, Farber DB. PMID: 21931697.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011; 17:2011-8. Saghizadeh M, Gribanova Y, Akhmedov NB, Farber DB. PMID: 21850176.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Regulation of retinoschisin secretion in Weri-Rb1 cells by the F-actin and microtubule cytoskeleton. PLoS One. 2011; 6(6):e20707. Kitamura E, Gribanova YE, Farber DB. PMID: 21738583.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. ZBED4, a novel retinal protein expressed in cones and Müller cells. Adv Exp Med Biol. 2010; 664:79-87. Farber DB, Theendakara VP, Akhmedov NB, Saghizadeh M. PMID: 20238005.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. Am J Hum Genet. 2009 May; 84(5):683-91. Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, Johnson CA, Booth AP, Jafri H, Rashid Y, Banin E, Strom TM, Farber DB, Sharon D, Blobel CP, Pugh EN, Pierce EA, Inglehearn CF. PMID: 19409519.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    15. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3580-8. Saghizadeh M, Akhmedov NB, Yamashita CK, Gribanova Y, Theendakara V, Mendoza E, Nelson SF, Ljubimov AV, Farber DB. PMID: 19369242.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One. 2009; 4(3):e4722. Yuan A, Farber EL, Rapoport AL, Tejada D, Deniskin R, Akhmedov NB, Farber DB. PMID: 19266099.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    17. Regulatory sequences in the 3' untranslated region of the human cGMP-phosphodiesterase beta-subunit gene. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2591-8. Verardo MR, Viczian A, Piri N, Akhmedov NB, Knox BE, Farber DB. PMID: 19218616.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration. Exp Eye Res. 2008 Sep; 87(3):168-75. Souied EH, Reid SN, Piri NI, Lerner LE, Nusinowitz S, Farber DB. PMID: 18653181.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    19. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):3245-52. Young A, Powelson EB, Whitney IE, Raven MA, Nusinowitz S, Jiang M, Birnbaumer L, Reese BE, Farber DB. PMID: 18378571.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. Identification and characterization of genes expressed in cone photoreceptors. Adv Exp Med Biol. 2008; 613:235-44. Saghizadeh M, Akhmedov NB, Farber DB. PMID: 18188950.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Evidence for retinal remodelling in retinitis pigmentosa caused by PDE6B mutation. Br J Ophthalmol. 2007 May; 91(5):699-701. Jacobson SG, Sumaroka A, Aleman TS, Cideciyan AV, Danciger M, Farber DB. PMID: 17446517.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    22. Replication and refinement of linkage of posterior polymorphous corneal dystrophy to the posterior polymorphous corneal dystrophy 1 locus on chromosome 20. Genet Med. 2007 Apr; 9(4):228-34. Yellore VS, Papp JC, Sobel E, Khan MA, Rayner SA, Farber DB, Aldave AJ. PMID: 17438387.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum Mutat. 2007 Mar; 28(3):243-54. Tsang SH, Woodruff ML, Jun L, Mahajan V, Yamashita CK, Pedersen R, Lin CS, Goff SP, Rosenberg T, Larsen M, Farber DB, Nusinowitz S. PMID: 17044014.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    24. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. Mol Vis. 2007 Feb 28; 13:287-92. Gao YQ, Danciger M, Ozgul RK, Gribanova Y, Jacobson S, Farber DB. PMID: 17356515.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Translational regulation of the rod photoreceptor cGMP-phosphodiesterase: the role of the 5'- and 3'-untranslated regions. Exp Eye Res. 2006 Oct; 83(4):841-8. Piri N, Mendoza E, Shih J, Yamashita CK, Akhmedov NB, Farber DB. PMID: 16765946.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. J Neurosci. 2006 Apr 26; 26(17):4472-80. Tsang SH, Woodruff ML, Chen CK, Yamashita CY, Cilluffo MC, Rao AL, Farber DB, Fain GL. PMID: 16641226.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    27. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1293-301. Kitamura E, Danciger M, Yamashita C, Rao NP, Nusinowitz S, Chang B, Farber DB. PMID: 16565360.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Transcriptional and post-transcriptional regulation of the rod cGMP-phosphodiesterase beta-subunit gene. Recent advances and current concepts. Adv Exp Med Biol. 2006; 572:217-29. Lerner LE, Piri N, Farber DB. PMID: 17249578.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. Morphological characterization of the retinal degeneration in three strains of mice carrying the rd-3 mutation. Vis Neurosci. 2005 Nov-Dec; 22(6):721-34. Linberg KA, Fariss RN, Heckenlively JR, Farber DB, Fisher SK. PMID: 16469183.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Early markers of retinal degeneration in rd/rd mice. Mol Vis. 2005 Sep 06; 11:717-28. Acosta ML, Fletcher EL, Azizoglu S, Foster LE, Farber DB, Kalloniatis M. PMID: 16163270.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    31. Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. J Biol Chem. 2005 May 27; 280(21):20642-50. Lerner LE, Peng GH, Gribanova YE, Chen S, Farber DB. PMID: 15781457.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    32. Glial transcytosis of a photoreceptor-secreted signaling protein, retinoschisin. Glia. 2005 Feb; 49(3):397-406. Reid SN, Farber DB. PMID: 15538749.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Two forms of the large tumor suppressor gene (Lats1) protein expressed in the vertebrate retina. Biochim Biophys Acta. 2005 Apr 05; 1728(1-2):11-7. Akhmedov NB, Yamashita CK, Tran D, Piri NI, Aguirre GD, Farber DB. PMID: 15777619.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy. Ophthalmology. 2005 Jan; 112(1):159-66. Piri N, Gao YQ, Danciger M, Mendoza E, Fishman GA, Farber DB. PMID: 15629837.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    35. Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65. Exp Eye Res. 2003 Nov; 77(5):627-38. Nusinowitz S, Nguyen L, Radu R, Kashani Z, Farber D, Danciger M. PMID: 14550405.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    36. Differential expression of rod photoreceptor cGMP-phosphodiesterase alpha and beta subunits: mRNA and protein levels. J Biol Chem. 2003 Sep 26; 278(39):36999-7005. Piri N, Yamashita CK, Shih J, Akhmedov NB, Farber DB. PMID: 12871955.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and muller cells. J Neurosci. 2003 Jul 09; 23(14):6030-40. Reid SN, Yamashita C, Farber DB. PMID: 12853421.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    38. Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma. Front Biosci. 2003 May 01; 8:s666-75. Farber DB, Tsang SH. PMID: 12700134.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    39. Expression of cone photoreceptor cGMP-phosphodiesterase alpha' subunit in Chinese hamster ovary, 293 human embryonic kidney, and Y79 retinoblastoma cells. Mol Vis. 2003 Mar 24; 9:80-6. Piriev NI, Yamashita CK, Shih J, Farber DB. PMID: 12655284.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Evaluation of techniques using amplified nucleic acid probes for gene expression profiling. Biomol Eng. 2003 Mar; 20(3):97-106. Saghizadeh M, Brown DJ, Tajbakhsh J, Chen Z, Kenney MC, Farber DB, Nelson SF. PMID: 12684071.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    41. Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5698-703. Gao J, Cheon K, Nusinowitz S, Liu Q, Bei D, Atkins K, Azimi A, Daiger SP, Farber DB, Heckenlively JR, Pierce EA, Sullivan LS, Zuo J. PMID: 11960024.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    42. The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX. J Biol Chem. 2002 Jul 19; 277(29):25877-83. Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB. PMID: 11943774.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    43. Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog. Mol Vis. 2002 Mar 22; 8:79-84. Akhmedov NB, Baldwin VJ, Zangerl B, Kijas JW, Hunter L, Minoofar KD, Mellersh C, Ostrander EA, Acland GM, Farber DB, Aguirre GD. PMID: 11951083.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    44. The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo. Vision Res. 2002 Feb; 42(4):439-45. Tsang SH, Yamashita CK, Lee WH, Lin CS, Goff SP, Gouras P, Farber DB. PMID: 11853759.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    45. Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci. 2002 Jan; 43(1):22-32. Liu Q, Zhou J, Daiger SP, Farber DB, Heckenlively JR, Smith JE, Sullivan LS, Zuo J, Milam AH, Pierce EA. PMID: 11773008.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    46. Identification of genes causing photoreceptor degenerations leading to blindness. Curr Opin Neurobiol. 1997 Oct; 7(5):666-73. Farber DB, Danciger M. PMID: 9384551.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells