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Farber, Debora B

Title(s)Professor, Ophthalmology
Phone3102064204
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    Collapse Research 
    Collapse Research Activities and Funding
    Vision Science Training Program
    NIH/NEI T32EY007026Dec 1, 2016 - Sep 29, 2017
    Role: Co-Principal Investigator
    Stem Cell Microvesicles: Potential Tools for Retinal Regeneration
    NIH/NEI R21EY018739Dec 1, 2007 - Nov 30, 2009
    Role: Principal Investigator
    Transgenic/Molecular Approaches for Ocular Albinism
    NIH/NEI R01EY015141Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Pathfinding of Ganglion Cell Axons and Ocular Albinism
    NIH/NEI R03EY013739Aug 1, 2001 - Jun 30, 2003
    Role: Principal Investigator
    Molecular Mechanisms in Retinal Degeneration
    NIH/NEI R01EY008285Aug 1, 1989 - Nov 30, 2012
    Role: Principal Investigator
    PHOSPHODIESTERASES IN PHOTORECEPTOR METABOLISM &DISEASE
    NIH/NEI R01EY002651Aug 1, 1978 - Jul 31, 2006
    Role: Principal Investigator
    CYCLIC NUCLEOTIDES IN CONE METABOLISM AND DISEASE
    NIH/NEI R37EY002651Aug 1, 1978 - Jul 31, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baulier E, Garcia Diaz A, Corneo B, Farber DB. Generation of a human Ocular Albinism type 1 iPSC line, SEIi001-A, with a mutation in GPR143. Stem Cell Res. 2018 12; 33:274-277. PMID: 30513407.
      View in: PubMed
    2. Peng Y, Baulier E, Ke Y, Young A, Ahmedli NB, Schwartz SD, Farber DB. Human embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells. PLoS One. 2018; 13(3):e0194004. PMID: 29538408.
      View in: PubMed
    3. Young A, Dandekar U, Pan C, Sader A, Zheng JJ, Lewis RA, Farber DB. GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism. PLoS One. 2016; 11(9):e0162273. PMID: 27607449.
      View in: PubMed
    4. Farber DB, Katsman D. Embryonic Stem Cell-Derived Microvesicles: Could They be Used for Retinal Regeneration? Adv Exp Med Biol. 2016; 854:563-9. PMID: 26427460.
      View in: PubMed
    5. Young A, Wang Y, Ahmedli NB, Jiang M, Farber DB. A constitutively active Gai3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1-/- mice. PLoS One. 2013; 8(9):e76240. PMID: 24098784.
      View in: PubMed
    6. Ahmedli NB, Gribanova Y, Njoku CC, Naidu A, Young A, Mendoza E, Yamashita CK, Ozgül RK, Johnson JE, Fox DA, Farber DB. Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. J Biol Chem. 2013 Apr 05; 288(14):9742-54. PMID: 23386608.
      View in: PubMed
    7. Katsman D, Stackpole EJ, Domin DR, Farber DB. Embryonic stem cell-derived microvesicles induce gene expression changes in Müller cells of the retina. PLoS One. 2012; 7(11):e50417. PMID: 23226281.
      View in: PubMed
    8. Strom SP, Gao YQ, Martinez A, Ortube C, Chen Z, Nelson SF, Nusinowitz S, Farber DB, Gorin MB. Molecular diagnosis of putative Stargardt Disease probands by exome sequencing. BMC Med Genet. 2012 Aug 03; 13:67. PMID: 22863181.
      View in: PubMed
    9. Mokhonov VV, Theendakara VP, Gribanova YE, Ahmedli NB, Farber DB. Sequence-specific binding of recombinant Zbed4 to DNA: insights into Zbed4 participation in gene transcription and its association with other proteins. PLoS One. 2012; 7(5):e35317. PMID: 22693546.
      View in: PubMed
    10. Young A, Jiang M, Wang Y, Ahmedli NB, Ramirez J, Reese BE, Birnbaumer L, Farber DB. Specific interaction of Gai3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium. PLoS One. 2011; 6(9):e24376. PMID: 21931697.
      View in: PubMed
    11. Saghizadeh M, Gribanova Y, Akhmedov NB, Farber DB. ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011; 17:2011-8. PMID: 21850176.
      View in: PubMed
    12. Kitamura E, Gribanova YE, Farber DB. Regulation of retinoschisin secretion in Weri-Rb1 cells by the F-actin and microtubule cytoskeleton. PLoS One. 2011; 6(6):e20707. PMID: 21738583.
      View in: PubMed
    13. Farber DB, Theendakara VP, Akhmedov NB, Saghizadeh M. ZBED4, a novel retinal protein expressed in cones and Müller cells. Adv Exp Med Biol. 2010; 664:79-87. PMID: 20238005.
      View in: PubMed
    14. Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, Johnson CA, Booth AP, Jafri H, Rashid Y, Banin E, Strom TM, Farber DB, Sharon D, Blobel CP, Pugh EN, Pierce EA, Inglehearn CF. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. Am J Hum Genet. 2009 May; 84(5):683-91. PMID: 19409519.
      View in: PubMed
    15. Saghizadeh M, Akhmedov NB, Yamashita CK, Gribanova Y, Theendakara V, Mendoza E, Nelson SF, Ljubimov AV, Farber DB. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3580-8. PMID: 19369242.
      View in: PubMed
    16. Yuan A, Farber EL, Rapoport AL, Tejada D, Deniskin R, Akhmedov NB, Farber DB. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One. 2009; 4(3):e4722. PMID: 19266099.
      View in: PubMed
    17. Verardo MR, Viczian A, Piri N, Akhmedov NB, Knox BE, Farber DB. Regulatory sequences in the 3' untranslated region of the human cGMP-phosphodiesterase beta-subunit gene. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2591-8. PMID: 19218616.
      View in: PubMed
    18. Souied EH, Reid SN, Piri NI, Lerner LE, Nusinowitz S, Farber DB. Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration. Exp Eye Res. 2008 Sep; 87(3):168-75. PMID: 18653181.
      View in: PubMed
    19. Young A, Powelson EB, Whitney IE, Raven MA, Nusinowitz S, Jiang M, Birnbaumer L, Reese BE, Farber DB. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):3245-52. PMID: 18378571.
      View in: PubMed
    20. Saghizadeh M, Akhmedov NB, Farber DB. Identification and characterization of genes expressed in cone photoreceptors. Adv Exp Med Biol. 2008; 613:235-44. PMID: 18188950.
      View in: PubMed
    21. Jacobson SG, Sumaroka A, Aleman TS, Cideciyan AV, Danciger M, Farber DB. Evidence for retinal remodelling in retinitis pigmentosa caused by PDE6B mutation. Br J Ophthalmol. 2007 May; 91(5):699-701. PMID: 17446517.
      View in: PubMed
    22. Yellore VS, Papp JC, Sobel E, Khan MA, Rayner SA, Farber DB, Aldave AJ. Replication and refinement of linkage of posterior polymorphous corneal dystrophy to the posterior polymorphous corneal dystrophy 1 locus on chromosome 20. Genet Med. 2007 Apr; 9(4):228-34. PMID: 17438387.
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    23. Tsang SH, Woodruff ML, Jun L, Mahajan V, Yamashita CK, Pedersen R, Lin CS, Goff SP, Rosenberg T, Larsen M, Farber DB, Nusinowitz S. Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum Mutat. 2007 Mar; 28(3):243-54. PMID: 17044014.
      View in: PubMed
    24. Gao YQ, Danciger M, Ozgul RK, Gribanova Y, Jacobson S, Farber DB. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. Mol Vis. 2007 Feb 28; 13:287-92. PMID: 17356515.
      View in: PubMed
    25. Piri N, Mendoza E, Shih J, Yamashita CK, Akhmedov NB, Farber DB. Translational regulation of the rod photoreceptor cGMP-phosphodiesterase: the role of the 5'- and 3'-untranslated regions. Exp Eye Res. 2006 Oct; 83(4):841-8. PMID: 16765946.
      View in: PubMed
    26. Tsang SH, Woodruff ML, Chen CK, Yamashita CY, Cilluffo MC, Rao AL, Farber DB, Fain GL. GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. J Neurosci. 2006 Apr 26; 26(17):4472-80. PMID: 16641226.
      View in: PubMed
    27. Kitamura E, Danciger M, Yamashita C, Rao NP, Nusinowitz S, Chang B, Farber DB. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1293-301. PMID: 16565360.
      View in: PubMed
    28. Lerner LE, Piri N, Farber DB. Transcriptional and post-transcriptional regulation of the rod cGMP-phosphodiesterase beta-subunit gene. Recent advances and current concepts. Adv Exp Med Biol. 2006; 572:217-29. PMID: 17249578.
      View in: PubMed
    29. Linberg KA, Fariss RN, Heckenlively JR, Farber DB, Fisher SK. Morphological characterization of the retinal degeneration in three strains of mice carrying the rd-3 mutation. Vis Neurosci. 2005 Nov-Dec; 22(6):721-34. PMID: 16469183.
      View in: PubMed
    30. Acosta ML, Fletcher EL, Azizoglu S, Foster LE, Farber DB, Kalloniatis M. Early markers of retinal degeneration in rd/rd mice. Mol Vis. 2005 Sep 06; 11:717-28. PMID: 16163270.
      View in: PubMed
    31. Lerner LE, Peng GH, Gribanova YE, Chen S, Farber DB. Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. J Biol Chem. 2005 May 27; 280(21):20642-50. PMID: 15781457.
      View in: PubMed
    32. Reid SN, Farber DB. Glial transcytosis of a photoreceptor-secreted signaling protein, retinoschisin. Glia. 2005 Feb; 49(3):397-406. PMID: 15538749.
      View in: PubMed
    33. Akhmedov NB, Yamashita CK, Tran D, Piri NI, Aguirre GD, Farber DB. Two forms of the large tumor suppressor gene (Lats1) protein expressed in the vertebrate retina. Biochim Biophys Acta. 2005 Apr 05; 1728(1-2):11-7. PMID: 15777619.
      View in: PubMed
    34. Piri N, Gao YQ, Danciger M, Mendoza E, Fishman GA, Farber DB. A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy. Ophthalmology. 2005 Jan; 112(1):159-66. PMID: 15629837.
      View in: PubMed
    35. Nusinowitz S, Nguyen L, Radu R, Kashani Z, Farber D, Danciger M. Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65. Exp Eye Res. 2003 Nov; 77(5):627-38. PMID: 14550405.
      View in: PubMed
    36. Piri N, Yamashita CK, Shih J, Akhmedov NB, Farber DB. Differential expression of rod photoreceptor cGMP-phosphodiesterase alpha and beta subunits: mRNA and protein levels. J Biol Chem. 2003 Sep 26; 278(39):36999-7005. PMID: 12871955.
      View in: PubMed
    37. Reid SN, Yamashita C, Farber DB. Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and muller cells. J Neurosci. 2003 Jul 09; 23(14):6030-40. PMID: 12853421.
      View in: PubMed
    38. Farber DB, Tsang SH. Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma. Front Biosci. 2003 May 01; 8:s666-75. PMID: 12700134.
      View in: PubMed
    39. Piriev NI, Yamashita CK, Shih J, Farber DB. Expression of cone photoreceptor cGMP-phosphodiesterase alpha' subunit in Chinese hamster ovary, 293 human embryonic kidney, and Y79 retinoblastoma cells. Mol Vis. 2003 Mar 24; 9:80-6. PMID: 12655284.
      View in: PubMed
    40. Saghizadeh M, Brown DJ, Tajbakhsh J, Chen Z, Kenney MC, Farber DB, Nelson SF. Evaluation of techniques using amplified nucleic acid probes for gene expression profiling. Biomol Eng. 2003 Mar; 20(3):97-106. PMID: 12684071.
      View in: PubMed
    41. Gao J, Cheon K, Nusinowitz S, Liu Q, Bei D, Atkins K, Azimi A, Daiger SP, Farber DB, Heckenlively JR, Pierce EA, Sullivan LS, Zuo J. Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5698-703. PMID: 11960024.
      View in: PubMed
    42. Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB. The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX. J Biol Chem. 2002 Jul 19; 277(29):25877-83. PMID: 11943774.
      View in: PubMed
    43. Akhmedov NB, Baldwin VJ, Zangerl B, Kijas JW, Hunter L, Minoofar KD, Mellersh C, Ostrander EA, Acland GM, Farber DB, Aguirre GD. Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog. Mol Vis. 2002 Mar 22; 8:79-84. PMID: 11951083.
      View in: PubMed
    44. Tsang SH, Yamashita CK, Lee WH, Lin CS, Goff SP, Gouras P, Farber DB. The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo. Vision Res. 2002 Feb; 42(4):439-45. PMID: 11853759.
      View in: PubMed
    45. Liu Q, Zhou J, Daiger SP, Farber DB, Heckenlively JR, Smith JE, Sullivan LS, Zuo J, Milam AH, Pierce EA. Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci. 2002 Jan; 43(1):22-32. PMID: 11773008.
      View in: PubMed
    46. Farber DB, Danciger M. Identification of genes causing photoreceptor degenerations leading to blindness. Curr Opin Neurobiol. 1997 Oct; 7(5):666-73. PMID: 9384551.
      View in: PubMed