Diana M Shih

Title(s)Adjunct Professor, Medicine
SchoolMedicine
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    1. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Sci Rep. 2021 Aug 12; 11(1):16409. Guo F, Seldin M, Péterfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. PMID: 34385484.
      View in: PubMed   Mentions:    Fields:    
    2. Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2021 09; 41(9):2494-2508. León-Mimila P, Villamil-Ramírez H, Macías-Kauffer LR, Jacobo-Albavera L, López-Contreras BE, Posadas-Sánchez R, Posadas-Romero C, Romero-Hidalgo S, Morán-Ramos S, Domínguez-Pérez M, Olivares-Arevalo M, López-Montoya P, Nieto-Guerra R, Acuña-Alonzo V, Macín-Pérez G, Barquera-Lozano R, Del-Río-Navarro BE, González-González I, Campos-Pérez F, Gómez-Pérez F, Valdés VJ, Sampieri A, Reyes-García JG, Carrasco-Portugal MDC, Flores-Murrieta FJ, Aguilar-Salinas CA, Vargas-Alarcón G, Shih D, Meikle PJ, Calkin AC, Drew BG, Vaca L, Lusis AJ, Huertas-Vazquez A, Villarreal-Molina T, Canizales-Quinteros S. PMID: 34233476.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide. JACC Basic Transl Sci. 2021 Feb; 6(2):103-115. Li DY, Wang Z, Jia X, Yan D, Shih DM, Hazen SL, Lusis AJ, Tang WHW. PMID: 33665512.
      View in: PubMed   Mentions:
    4. Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. Sci Rep. 2021 01 12; 11(1):518. Zhang W, Miikeda A, Zuckerman J, Jia X, Charugundla S, Zhou Z, Kaczor-Urbanowicz KE, Magyar C, Guo F, Wang Z, Pellegrini M, Hazen SL, Nicholas SB, Lusis AJ, Shih DM. PMID: 33436815.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):220-233. Sinha SK, Miikeda A, Fouladian Z, Mehrabian M, Edillor C, Shih D, Zhou Z, Paul MK, Charugundla S, Davis RC, Rajavashisth TB, Lusis AJ. PMID: 33086870.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice. Sci Rep. 2020 10 08; 10(1):16848. Charles-Schoeman C, Wang J, Shahbazian A, Lee YY, Wang X, Grijalva V, Brahn E, Shih DM, Devarajan A, Montano C, Lusis AJ, Reddy ST. PMID: 33033318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. Diabetes Metab. 2021 03; 47(2):101183. León-Mimila P, Villamil-Ramírez H, Li XS, Shih DM, Hui ST, Ocampo-Medina E, López-Contreras B, Morán-Ramos S, Olivares-Arevalo M, Grandini-Rosales P, Macías-Kauffer L, González-González I, Hernández-Pando R, Gómez-Pérez F, Campos-Pérez F, Aguilar-Salinas C, Larrieta-Carrasco E, Villarreal-Molina T, Wang Z, Lusis AJ, Hazen SL, Huertas-Vazquez A, Canizales-Quinteros S. PMID: 32791310.
      View in: PubMed   Mentions: 6     Fields:    
    8. Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1776-1786. Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA. PMID: 31340670.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report. Arterioscler Thromb Vasc Biol. 2019 06; 39(6):1045-1054. Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, Lusis AJ. PMID: 31070450.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    10. PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. Antioxidants (Basel). 2019 Jan 11; 8(1). Shih DM, Meng Y, Sallam T, Vergnes L, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST. PMID: 30641857.
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    11. Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis. Nutr Metab Cardiovasc Dis. 2019 03; 29(3):306-315. Kim S, Graham MJ, Lee RG, Yang L, Kim S, Subramanian V, Layne JD, Cai L, Temel RE, Shih D, Lusis AJ, Berliner JA, Lee S. PMID: 30738642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates. Biochem Biophys Res Commun. 2018 10 20; 505(1):87-92. Teiber JF, Xiao J, Kramer GL, Ogawa S, Ebner C, Wolleb H, Carreira EM, Shih DM, Haley RW. PMID: 30241945.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk. J Thromb Haemost. 2018 09; 16(9):1857-1872. Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, Gupta N, Gregory JC, Org E, Fu X, Li L, DiDonato JA, Lusis AJ, Brown JM, Hazen SL. PMID: 29981269.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    14. Paraoxonase 2 prevents the development of heart failure. Free Radic Biol Med. 2018 06; 121:117-126. Li W, Kennedy D, Shao Z, Wang X, Kamdar AK, Weber M, Mislick K, Kiefer K, Morales R, Agatisa-Boyle B, Shih DM, Reddy ST, Moravec CS, Tang WHW. PMID: 29729330.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metab. 2018 May 01; 27(5):1138-1155.e6. Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ. PMID: 29719227.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    16. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Rep. 2017 07 05; 20(1):279. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM. PMID: 28683320.
      View in: PubMed   Mentions: 7     Fields:    
    17. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Rep. 2017 06 20; 19(12):2451-2461. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM. PMID: 28636934.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    18. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J Am Heart Assoc. 2016 Feb 22; 5(2). Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. PMID: 26903003.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    19. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Rep. 2015 Jan 20; 10(3):326-338. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. PMID: 25600868.
      View in: PubMed   Mentions: 129     Fields:    
    20. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J. 2015 Apr; 29(4):1185-97. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis AJ. PMID: 25477283; PMCID: PMC4396607.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015 Jan; 56(1):22-37. Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ. PMID: 25378658.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    22. Genetic regulation of mouse liver metabolite levels. Mol Syst Biol. 2014 May 23; 10:730. Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ. PMID: 24860088.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    23. Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice. PLoS Genet. 2014 Jan; 10(1):e1004022. Kang EY, Han B, Furlotte N, Joo JW, Shih D, Davis RC, Lusis AJ, Eskin E. PMID: 24415945.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    24. Inflammation, infection, cancer and all that…the role of paraoxonases. Adv Exp Med Biol. 2014; 824:33-41. Devarajan A, Shih D, Reddy ST. PMID: 25038992.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    25. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest. 2013 Sep; 123(9):3815-28. Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, Smith JD, Plow EF, Fox PL, Shih DM, Lusis AJ, Fisher EA, DiDonato JA, Landmesser U, Hazen SL. PMID: 23908111.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    26. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep; 27(9):3805-17. Shih DM, Shaposhnik Z, Meng Y, Rosales M, Wang X, Wu J, Ratiner B, Zadini F, Zadini G, Lusis AJ. PMID: 23752203.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    27. Paraoxonase-1 inhibits oxidized low-density lipoprotein-induced metabolic alterations and apoptosis in endothelial cells: a nondirected metabolomic study. Mediators Inflamm. 2013; 2013:156053. García-Heredia A, Marsillach J, Rull A, Triguero I, Fort I, Mackness B, Mackness M, Shih DM, Joven J, Camps J. PMID: 23766557.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    28. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24; 112(11):e152-3. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 23625949.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    29. Paraoxonase-1 deficiency is associated with severe liver steatosis in mice fed a high-fat high-cholesterol diet: a metabolomic approach. J Proteome Res. 2013 Apr 05; 12(4):1946-55. García-Heredia A, Kensicki E, Mohney RP, Rull A, Triguero I, Marsillach J, Tormos C, Mackness B, Mackness M, Shih DM, Pedro-Botet J, Joven J, Sáez G, Camps J. PMID: 23448543.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    30. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 08; 17(1):49-60. Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. PMID: 23312283.
      View in: PubMed   Mentions: 293     Fields:    Translation:HumansAnimalsCells
    31. Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):19-24. Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y. PMID: 23291186.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17; 111(5):516-20. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 22811557.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ. 2012 Sep; 19(9):1549-60. Schweikert EM, Devarajan A, Witte I, Wilgenbus P, Amort J, Förstermann U, Shabazian A, Grijalva V, Shih DM, Farias-Eisner R, Teiber JF, Reddy ST, Horke S. PMID: 22441669.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    34. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. J Alzheimers Dis. 2012; 30(2):225-31. Borowczyk K, Shih DM, Jakubowski H. PMID: 22406444.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    35. Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2624-33. Kim JB, Xia YR, Romanoski CE, Lee S, Meng Y, Shi YS, Bourquard N, Gong KW, Port Z, Grijalva V, Reddy ST, Berliner JA, Lusis AJ, Shih DM. PMID: 21836061.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    36. Paraoxonase-1 and clopidogrel efficacy. Nat Med. 2011 Sep 07; 17(9):1041-2; author reply 1042-4. Camps J, Joven J, Mackness B, Mackness M, Tawfik D, Draganov D, Costa LG, Paragh G, Seres I, Horke S, James R, Hernández A, Reddy S, Shih D, Navab M, Rochu D, Aviram M. PMID: 21900915.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest. 2011 Jul; 121(7):2693-708. Besler C, Heinrich K, Rohrer L, Doerries C, Riwanto M, Shih DM, Chroni A, Yonekawa K, Stein S, Schaefer N, Mueller M, Akhmedov A, Daniil G, Manes C, Templin C, Wyss C, Maier W, Tanner FC, Matter CM, Corti R, Furlong C, Lusis AJ, von Eckardstein A, Fogelman AM, Lüscher TF, Landmesser U. PMID: 21701070.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimals
    38. Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis. Adv Exp Med Biol. 2010; 660:73-87. Shih DM, Xia YR, Yu JM, Lusis AJ. PMID: 20221872.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    39. A common mutation in paraoxonase-2 results in impaired lactonase activity. J Biol Chem. 2009 Dec 18; 284(51):35564-71. Stoltz DA, Ozer EA, Recker TJ, Estin M, Yang X, Shih DM, Lusis AJ, Zabner J. PMID: 19840942.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Curr Opin Lipidol. 2009 Aug; 20(4):288-92. Shih DM, Lusis AJ. PMID: 19474728.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    41. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J. 2009 Jun; 23(6):1721-7. Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. PMID: 19204075.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    42. Is it just paraoxonase 1 or are other members of the paraoxonase gene family implicated in atherosclerosis? Curr Opin Lipidol. 2008 Aug; 19(4):405-8. Reddy ST, Devarajan A, Bourquard N, Shih D, Fogelman AM. PMID: 18607188.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    43. Cells deficient in oxidative DNA damage repair genes Myh and Ogg1 are sensitive to oxidants with increased G2/M arrest and multinucleation. Carcinogenesis. 2008 Apr; 29(4):722-8. Xie Y, Yang H, Miller JH, Shih DM, Hicks GG, Xie J, Shiu RP. PMID: 18258604.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    44. FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. Toxicol Sci. 2007 Dec; 100(2):474-85. Martin LJ, Chen H, Liao X, Allayee H, Shih DM, Lee GS, Hovland DN, Robbins WA, Carnes K, Hess RA, Lusis AJ, Collins MD. PMID: 17785681.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    45. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res. 2007 Jun 22; 100(12):1703-11. Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ, Araujo JA. PMID: 17495224.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    46. Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1368-74. Ng CJ, Bourquard N, Hama SY, Shih D, Grijalva VR, Navab M, Fogelman AM, Reddy ST. PMID: 17446441.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    47. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res. 2007 Apr 27; 100(8):1200-7. Shih DM, Xia YR, Wang XP, Wang SS, Bourquard N, Fogelman AM, Lusis AJ, Reddy ST. PMID: 17379834.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    48. Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J. 2007 Jun; 21(8):1707-13. Chwatko G, Boers GH, Strauss KA, Shih DM, Jakubowski H. PMID: 17327360.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    49. Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. . 2007 Apr; 292(4):L852-60. Stoltz DA, Ozer EA, Ng CJ, Yu JM, Reddy ST, Lusis AJ, Bourquard N, Parsek MR, Zabner J, Shih DM. PMID: 17122353.
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    50. Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J Biol Chem. 2006 Oct 06; 281(40):29491-500. Ng CJ, Bourquard N, Grijalva V, Hama S, Shih DM, Navab M, Fogelman AM, Lusis AJ, Young S, Reddy ST. PMID: 16891303.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    51. Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006 Nov; 114(3):240-5. Bhasin KK, Yu JM, Tward A, Shih D, Campbell DA, Lusis AJ. PMID: 16682028.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    52. Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice. Life Sci. 2006 Jul 04; 79(6):525-31. Miyoshi T, Li Y, Shih DM, Wang X, Laubach VE, Matsumoto AH, Helm GA, Lusis AJ, Shi W. PMID: 16516241.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    53. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature. 2005 Dec 08; 438(7069):803-19. Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, DeJong PJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abebe A, Abouelleil A, Aftuck L, Ait-Zahra M, Aldredge T, Allen N, An P, Anderson S, Antoine C, Arachchi H, Aslam A, Ayotte L, Bachantsang P, Barry A, Bayul T, Benamara M, Berlin A, Bessette D, Blitshteyn B, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Brown A, Cahill P, Calixte N, Camarata J, Cheshatsang Y, Chu J, Citroen M, Collymore A, Cooke P, Dawoe T, Daza R, Decktor K, DeGray S, Dhargay N, Dooley K, Dooley K, Dorje P, Dorjee K, Dorris L, Duffey N, Dupes A, Egbiremolen O, Elong R, Falk J, Farina A, Faro S, Ferguson D, Ferreira P, Fisher S, FitzGerald M, Foley K, Foley C, Franke A, Friedrich D, Gage D, Garber M, Gearin G, Giannoukos G, Goode T, Goyette A, Graham J, Grandbois E, Gyaltsen K, Hafez N, Hagopian D, Hagos B, Hall J, Healy C, Hegarty R, Honan T, Horn A, Houde N, Hughes L, Hunnicutt L, Husby M, Jester B, Jones C, Kamat A, Kanga B, Kells C, Khazanovich D, Kieu AC, Kisner P, Kumar M, Lance K, Landers T, Lara M, Lee W, Leger JP, Lennon N, Leuper L, LeVine S, Liu J, Liu X, Lokyitsang Y, Lokyitsang T, Lui A, Macdonald J, Major J, Marabella R, Maru K, Matthews C, McDonough S, Mehta T, Meldrim J, Melnikov A, Meneus L, Mihalev A, Mihova T, Miller K, Mittelman R, Mlenga V, Mulrain L, Munson G, Navidi A, Naylor J, Nguyen T, Nguyen N, Nguyen C, Nguyen T, Nicol R, Norbu N, Norbu C, Novod N, Nyima T, Olandt P, O'Neill B, O'Neill K, Osman S, Oyono L, Patti C, Perrin D, Phunkhang P, Pierre F, Priest M, Rachupka A, Raghuraman S, Rameau R, Ray V, Raymond C, Rege F, Rise C, Rogers J, Rogov P, Sahalie J, Settipalli S, Sharpe T, Shea T, Sheehan M, Sherpa N, Shi J, Shih D, Sloan J, Smith C, Sparrow T, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Stone S, Sykes S, Tchuinga P, Tenzing P, Tesfaye S, Thoulutsang D, Thoulutsang Y, Topham K, Topping I, Tsamla T, Vassiliev H, Venkataraman V, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Yang S, Yang X, Young G, Yu Q, Zainoun J, Zembek L, Zimmer A, Lander ES. PMID: 16341006.
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    54. A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. J Lipid Res. 2006 Feb; 47(2):384-92. Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis AJ. PMID: 16269825.
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    55. Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett. 2005 Dec 01; 253(1):29-37. Ozer EA, Pezzulo A, Shih DM, Chun C, Furlong C, Lusis AJ, Greenberg EP, Zabner J. PMID: 16260097.
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    56. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet Genomics. 2005 Aug; 15(8):589-98. Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. PMID: 16007003.
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    57. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology. 2005 Aug; 26(4):651-9. Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. PMID: 16112327.
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    58. Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice. Atherosclerosis. 2005 Jul; 181(1):9-18. Rozenberg O, Shih DM, Aviram M. PMID: 15939049.
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    59. The paraoxonase gene family and atherosclerosis. Free Radic Biol Med. 2005 Jan 15; 38(2):153-63. Ng CJ, Shih DM, Hama SY, Villa N, Navab M, Reddy ST. PMID: 15607899.
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    60. Paraoxonase 1 (PON1) status and risk of insecticide exposure. J Biochem Mol Toxicol. 2005; 19(3):182-3. Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. PMID: 15977192.
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    61. Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine. Atherosclerosis. 2005 Mar; 179(1):69-77. Rosenblat M, Vaya J, Shih D, Aviram M. PMID: 15721011.
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    62. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. PMID: 12874251.
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    63. Expression of human paraoxonase (PON1) during development. Pharmacogenetics. 2003 Jun; 13(6):357-64. Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. PMID: 12777966.
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    64. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Radic Biol Med. 2003 Mar 15; 34(6):774-84. Rozenberg O, Rosenblat M, Coleman R, Shih DM, Aviram M. PMID: 12633754.
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    65. Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. Arterioscler Thromb Vasc Biol. 2003 Mar 01; 23(3):461-7. Rozenberg O, Shih DM, Aviram M. PMID: 12615663.
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    66. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation. 2002 Jul 23; 106(4):484-90. Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis AJ, Shih DM. PMID: 12135950.
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    67. Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase. Circulation. 2002 Apr 30; 105(17):2078-82. Shi W, Wang X, Shih DM, Laubach VE, Navab M, Lusis AJ. PMID: 11980688.
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    68. Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. Arterioscler Thromb Vasc Biol. 2001 Apr; 21(4):542-7. Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM. PMID: 11304470.
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    69. The role of high-density lipoproteins in oxidation and inflammation. Trends Cardiovasc Med. 2001 Apr-May; 11(3-4):155-61. Van Lenten BJ, Navab M, Shih D, Fogelman AM, Lusis AJ. PMID: 11686006.
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    70. HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2001 Apr; 21(4):481-8. Navab M, Berliner JA, Subbanagounder G, Hama S, Lusis AJ, Castellani LW, Reddy S, Shih D, Shi W, Watson AD, Van Lenten BJ, Vora D, Fogelman AM. PMID: 11304461.
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    71. Increased atherosclerosis in myeloperoxidase-deficient mice. J Clin Invest. 2001 Feb; 107(4):419-30. Brennan ML, Anderson MM, Shih DM, Qu XD, Wang X, Mehta AC, Lim LL, Shi W, Hazen SL, Jacob JS, Crowley JR, Heinecke JW, Lusis AJ. PMID: 11181641.
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    72. Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics. 2000 Dec; 10(9):767-79. Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. PMID: 11191881.
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    73. The PON1 gene and detoxication. Neurotoxicology. 2000 Aug; 21(4):581-7. Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. PMID: 11022865.
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    74. Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. Circulation. 2000 Jul 04; 102(1):75-81. Shi W, Haberland ME, Jien ML, Shih DM, Lusis AJ. PMID: 10880418.
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    75. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem. 2000 Jun 09; 275(23):17527-35. Shih DM, Xia YR, Wang XP, Miller E, Castellani LW, Subbanagounder G, Cheroutre H, Faull KF, Berliner JA, Witztum JL, Lusis AJ. PMID: 10748217.
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    76. Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism. Circ Res. 2000 May 26; 86(10):1078-84. Shi W, Wang NJ, Shih DM, Sun VZ, Wang X, Lusis AJ. PMID: 10827138.
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    77. Cloning and characterization of a new member of the Nudix hydrolases from human and mouse. J Biol Chem. 2000 Mar 24; 275(12):8844-53. Yang H, Slupska MM, Wei YF, Tai JH, Luther WM, Xia YR, Shih DM, Chiang JH, Baikalov C, Fitz-Gibbon S, Phan IT, Conrad A, Miller JH. PMID: 10722730.
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    78. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). Neurotoxicology. 2000 Feb-Apr; 21(1-2):91-100. Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. PMID: 10794389.
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    79. Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q). Diabetes. 1999 Jul; 48(7):1459-65. Navas MA, Munoz-Elias EJ, Kim J, Shih D, Stoffel M. PMID: 10389854.
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    80. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chem Biol Interact. 1999 May 14; 119-120:429-38. Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. PMID: 10421480.
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    81. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism. Neurotoxicology. 1998 Aug-Oct; 19(4-5):645-50. Furlong CE, Li WF, Costa LG, Richter RJ, Shih DM, Lusis AJ. PMID: 9745924.
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    82. Paraoxonase and coronary heart disease. Curr Opin Lipidol. 1998 Aug; 9(4):319-24. Mackness MI, Mackness B, Durrington PN, Fogelman AM, Berliner J, Lusis AJ, Navab M, Shih D, Fonarow GC. PMID: 9739487.
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    83. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature. 1998 Jul 16; 394(6690):284-7. Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ. PMID: 9685159.
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    84. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics. 1998 Jun 01; 50(2):199-205. Jiang Z, Shih DM, Xia YR, Lusis AJ, de Beer FC, de Villiers WJ, van der Westhuyzen DR, de Beer MC. PMID: 9653646.
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    85. Taurine inhibition of iron-stimulated catecholamine oxidation. Adv Exp Med Biol. 1998; 442:155-62. Dawson R, Tang E, Shih D, Hern H, Hu M, Baker D, Eppler B. PMID: 9635027.
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    86. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol. 1996 Jul; 16(7):831-42. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. PMID: 8673557.
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    87. Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. J Clin Invest. 1996 Apr 01; 97(7):1630-9. Shih DM, Gu L, Hama S, Xia YR, Navab M, Fogelman AM, Lusis AJ. PMID: 8601628.
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    88. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. Genomics. 1996 Mar 15; 32(3):328-33. Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ. PMID: 8838795.
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    89. The effects of taurine in a rodent model of aging. Adv Exp Med Biol. 1996; 403:37-50. Dawson R, Eppler B, Patterson TA, Shih D, Liu S. PMID: 8915339.
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    90. New insights into atherosclerosis from studies with mouse models. Mol Med Today. 1995 Nov; 1(8):364-72. Shih DM, Welch C, Lusis AJ. PMID: 9415182.
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    91. A 5' control region of the human epsilon-globin gene is sufficient for embryonic specificity in transgenic mice. J Biol Chem. 1993 Feb 15; 268(5):3066-71. Shih DM, Wall RJ, Shapiro SG. PMID: 8428985.
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    92. Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. DNA Cell Biol. 1992 Nov; 11(9):693-9. Karimpour I, Cutler M, Shih D, Smith J, Kleene KC. PMID: 1418626.
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    93. A study by in situ hybridization of the stage of appearance and disappearance of the transition protein 2 and the mitochondrial capsule seleno-protein mRNAs during spermatogenesis in the mouse. Mol Reprod Dev. 1992 Oct; 33(2):222-7. Shih DM, Kleene KC. PMID: 1418993.
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    94. Developmentally regulated and erythroid-specific expression of the human embryonic beta-globin gene in transgenic mice. Nucleic Acids Res. 1990 Sep 25; 18(18):5465-72. Shih DM, Wall RJ, Shapiro SG. PMID: 2216720.
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