Elie Besserer Offroy

Title(s)Assistant Adjunct Professor, Molecular and Medical Pharmacology
Address760 Westwood Plaza 23-120
Los Angeles CA 90024
ORCID ORCID Icon0000-0002-7473-7043 Additional info
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    Université de Franche-Comté, FranceASc06/2009Biology
    Université Claude-Bernard - Lyon I, FranceBMedSci06/2010Medical Biochemistry
    Université de Sherbrooke, Québec, CanadaPhD12/2017Pharmacology
    McGill University, Québec, CanadaPost-Doc12/2020Pharmacology & Therapeutics

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia. Behav Brain Res. 2021 Feb 16; 113189. Vivancos M, Fanelli R, Besserer-Offroy É, Beaulieu S, Chartier M, Resua-Rojas M, Mona CE, Previti S, Rémond E, Longpré JM, Cavelier F, Sarret P. PMID: 33607165.
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    2. Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR. Biomolecules. 2020 12 03; 10(12). Sadybekov AA, Brouillette RL, Marin E, Sadybekov AV, Luginina A, Gusach A, Mishin A, Besserer-Offroy É, Longpré JM, Borshchevskiy V, Cherezov V, Sarret P, Katritch V. PMID: 33287369.
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    3. Assessing Gαq/15-signaling with IP-One: Single Plate Transfection and Assay Protocol for Cell-Based High-Throughput Assay. Bio Protoc. 2020 Aug 20; 10(16):e3715. Besserer-Offroy É, Brouillette RL, Longpré JM, Sarret P. PMID: 33659379.
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    4. Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog. Data Brief. 2020 Aug; 31:105884. Besserer-Offroy É, Tétreault P, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent A, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P. PMID: 32637491.
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    5. Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog. Eur J Pharmacol. 2020 Sep 05; 882:173174. Tétreault P, Besserer-Offroy É, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P. PMID: 32534076.
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    6. Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. Pharmacol Res. 2020 05; 155:104750. Brouillette RL, Besserer-Offroy É, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P. PMID: 32151680.
      View in: PubMed   Mentions: 1     Fields:    
    7. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 12 06; 10(1):5573. Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V. PMID: 31811124.
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    8. Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Sci Adv. 2019 10; 5(10):eaax2518. Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V. PMID: 31633023.
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    9. Sending out Biased Signals: an Appropriate Proposition for Pain?. Douleur et analgésie. 2019; 32(2):108-110. Besserer-Offroy É, Sarret P. View Publication.
    10. Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells. Cell Physiol Biochem. 2019; 53(4):687-700. Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A. PMID: 31577078.
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    11. Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). J Med Chem. 2018 08 23; 61(16):7103-7115. Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. PMID: 30035538.
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    12. Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses. Pharmacol Res. 2018 10; 136:108-120. Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M. PMID: 29959993.
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    13. Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms. Biochem Pharmacol. 2018 08; 154:104-117. St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R. PMID: 29684376.
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    14. The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. Pharmacol Res. 2018 05; 131:7-16. Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P. PMID: 29530600.
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    15. In Search of the Optimal Macrocyclization Site for Neurotensin. ACS Med Chem Lett. 2018 Mar 08; 9(3):227-232. Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É. PMID: 29541365.
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    16. Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. J Med Chem. 2017 04 27; 60(8):3303-3313. Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F. PMID: 28368584.
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    17. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur J Pharmacol. 2017 Jun 15; 805:1-13. Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R. PMID: 28341345.
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    18. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org Biomol Chem. 2017 Jan 04; 15(2):449-458. Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É. PMID: 27924341.
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    19. Design, synthesis, and biological evaluation of CXCR4 ligands. Org Biomol Chem. 2016 Nov 02; 14(43):10298-10311. Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E. PMID: 27752700.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists. J Med Chem. 2016 08 25; 59(16):7512-24. Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E. PMID: 27434274.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chem Neurosci. 2016 09 21; 7(9):1225-31. Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P. PMID: 27359371.
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    22. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14; 59(7):2962-72. Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, Longpré JM, Lainé J, Reversade B, Salvail D, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É. PMID: 26986036.
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    23. Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. J Med Chem. 2015 Oct 08; 58(19):7785-95. Fanelli R, Besserer-Offroy É, René A, Côté J, Tétreault P, Collerette-Tremblay J, Longpré JM, Leduc R, Martinez J, Sarret P, Cavelier F. PMID: 26348111.
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    24. C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. J Med Chem. 2015 Mar 12; 58(5):2431-40. Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É. PMID: 25668242.
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    25. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J Clin Invest. 2014 Mar; 124(3):1199-213. Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. PMID: 24531547.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    26. Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability. ChemMedChem. 2012 Feb 06; 7(2):318-25. Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É. PMID: 22170700.
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