Elie Besserer Offroy

Title(s)Assistant Adjunct Professor, Molecular and Medical Pharmacology
SchoolMedicine
ORCID ORCID Icon0000-0002-7473-7043 Additional info
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    Dr. Besserer-Offroy is an Assistant Professor of Molecular and Medical Pharmacology at UCLA and a Faculty Lecturer at the Université de Montreal, School of Pharmacy. He received his Ph.D. in Pharmacology from the Université de Sherbrooke. During his doctoral studies, Elie investigated the relationships existing between G Protein-Coupled Receptors (GPCR) signaling in vitro and the observed physiological effects in vivo. He then pursued a Post-Doctoral Fellowship at McGill University where he studied the functional role of GPCR heterodimerization in the signaling processes in vitro and in vivo. Dr. Besserer-Offroy is the recipient of Fellowships from the Canadian Institutes of Health Research (CIHR) and Fonds de recherche du Québec – Santé (Quebec Health Research Funds).

    The Besserer Lab focuses on the development of novel and effective diagnostic probes and therapeutic molecules (theranostics) for brain cancer and especially glioblastomas. Our research is centered on targeting cell surface proteins expressed by cancer cells and stromal cells (support cells surrounding the tumor). We also aim to develop innovative ways to cross the blood-brain barrier using different techniques such as the use of conjugation with brain-penetrant molecules. Finally, we have an interest in personalized medicine and the use of innovative technology to identify tumors that are at the high potential to respond to a precise drug or combination of drugs. To achieve these goals, we use and develop in vitro, in vivo, and ex vivo techniques combining knowledge of pharmacology, biochemistry, cell biology, and physiology.

    The Besserer Lab is closely collaborating with the laboratories of Dr. David Nathanson and Dr. Johannes Czernin at the Ahmanson Translational Theranostics Division.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia. Behav Brain Res. 2021 05 07; 405:113189. Vivancos M, Fanelli R, Besserer-Offroy É, Beaulieu S, Chartier M, Resua-Rojas M, Mona CE, Previti S, Rémond E, Longpré JM, Cavelier F, Sarret P. PMID: 33607165.
      View in: PubMed   Mentions:    Fields:    
    2. Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR. Biomolecules. 2020 12 03; 10(12). Sadybekov AA, Brouillette RL, Marin E, Sadybekov AV, Luginina A, Gusach A, Mishin A, Besserer-Offroy É, Longpré JM, Borshchevskiy V, Cherezov V, Sarret P, Katritch V. PMID: 33287369.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Assessing Gαq/15-signaling with IP-One: Single Plate Transfection and Assay Protocol for Cell-Based High-Throughput Assay. Bio Protoc. 2020 Aug 20; 10(16):e3715. Besserer-Offroy É, Brouillette RL, Longpré JM, Sarret P. PMID: 33659379.
      View in: PubMed   Mentions:
    4. Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog. Data Brief. 2020 Aug; 31:105884. Besserer-Offroy É, Tétreault P, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent A, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P. PMID: 32637491.
      View in: PubMed   Mentions:
    5. Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog. Eur J Pharmacol. 2020 Sep 05; 882:173174. Tétreault P, Besserer-Offroy É, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P. PMID: 32534076.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. Pharmacol Res. 2020 05; 155:104750. Brouillette RL, Besserer-Offroy É, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P. PMID: 32151680.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 12 06; 10(1):5573. Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V. PMID: 31811124.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    8. Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Sci Adv. 2019 10; 5(10):eaax2518. Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V. PMID: 31633023.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Sending out Biased Signals: an Appropriate Proposition for Pain?. Douleur et analgésie. 2019; 32(2):108-110. . View Publication.
    10. Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells. Cell Physiol Biochem. 2019; 53(4):687-700. Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A. PMID: 31577078.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). J Med Chem. 2018 08 23; 61(16):7103-7115. Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. PMID: 30035538.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses. Pharmacol Res. 2018 10; 136:108-120. Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M. PMID: 29959993.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms. Biochem Pharmacol. 2018 08; 154:104-117. St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R. PMID: 29684376.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. Pharmacol Res. 2018 05; 131:7-16. Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P. PMID: 29530600.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. In Search of the Optimal Macrocyclization Site for Neurotensin. ACS Med Chem Lett. 2018 Mar 08; 9(3):227-232. Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É. PMID: 29541365.
      View in: PubMed   Mentions:
    16. Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. J Med Chem. 2017 04 27; 60(8):3303-3313. Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F. PMID: 28368584.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur J Pharmacol. 2017 Jun 15; 805:1-13. Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R. PMID: 28341345.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org Biomol Chem. 2017 Jan 04; 15(2):449-458. Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É. PMID: 27924341.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Design, synthesis, and biological evaluation of CXCR4 ligands. Org Biomol Chem. 2016 Nov 02; 14(43):10298-10311. Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E. PMID: 27752700.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists. J Med Chem. 2016 08 25; 59(16):7512-24. Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E. PMID: 27434274.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chem Neurosci. 2016 09 21; 7(9):1225-31. Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P. PMID: 27359371.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14; 59(7):2962-72. Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, Longpré JM, Lainé J, Reversade B, Salvail D, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É. PMID: 26986036.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    23. Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. J Med Chem. 2015 Oct 08; 58(19):7785-95. Fanelli R, Besserer-Offroy É, René A, Côté J, Tétreault P, Collerette-Tremblay J, Longpré JM, Leduc R, Martinez J, Sarret P, Cavelier F. PMID: 26348111.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. J Med Chem. 2015 Mar 12; 58(5):2431-40. Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É. PMID: 25668242.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J Clin Invest. 2014 Mar; 124(3):1199-213. Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. PMID: 24531547.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    26. Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability. ChemMedChem. 2012 Feb 06; 7(2):318-25. Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É. PMID: 22170700.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
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