Federico Kalinec

Title(s)Professor-in-Residence, Head and Neck Surgery
Address760 Westwood Plaza 62-132
Los Angeles CA 90024
Phone(213) 353-7030
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Inflammatory Responses in the Cochlea
    NIH/NIDCD R01DC010397Dec 1, 2009 - Nov 30, 2014
    Role: Principal Investigator
    Structural Basis of Outer Hair Cell Function
    NIH/NIDCD R01DC010146Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Cytoskeletal Regulation of Outer Hair Cell Motility
    NIH/NIDCD R01DC005220Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    Cytoskeletal Regulation of Outer Hair Cell Motility
    NIH/NIDCD R56DC005220Dec 1, 2001 - Jun 30, 2009
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells. BMJ Open Diabetes Res Care. 2020 03; 8(1). Pålbrink AK, Kopietz F, Morén B, In 't Zandt R, Kalinec F, Stenkula K, Göransson O, Holm C, Magnusson M, Degerman E. PMID: 32238362.
      View in: PubMed   Mentions:
    2. Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators. Front Cell Neurosci. 2019; 13:530. Kalinec GM, Gao L, Cohn W, Whitelegge JP, Faull KF, Kalinec F. PMID: 31849615.
      View in: PubMed   Mentions:
    3. Preliminary Characterization of Extracellular Vesicles From Auditory HEI-OC1 Cells. Ann Otol Rhinol Laryngol. 2019 06; 128(6_suppl):52S-60S. Kalinec GM, Cohn W, Whitelegge JP, Faull KF, Kalinec F. PMID: 31092033.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Prevention of cisplatin-induced hearing loss by extended release fluticasone propionate intracochlear implants. Int J Pediatr Otorhinolaryngol. 2019 Jun; 121:157-163. Pierstorff E, Yang WW, Chen YA, Cheung S, Kalinec F, Slattery WH. PMID: 30913504.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. A Polymer-Based Extended Release System for Stable, Long-term Intracochlear Drug Delivery. Otol Neurotol. 2018 10; 39(9):1195-1202. Pierstorff E, Chen S, Chaparro MP, Cortez JM, Chen YJ, Ryu SY, Tsai SM, Baum MM, Yang WW, Kalinec F, Smith T, Ludwig S, Slattery WH. PMID: 30199502.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. Front Cell Neurosci. 2017; 11:192. Kalinec GM, Lomberk G, Urrutia RA, Kalinec F. PMID: 28736517.
      View in: PubMed   Mentions:
    7. Working with Auditory HEI-OC1 Cells. J Vis Exp. 2016 09 03; (115). Kalinec GM, Park C, Thein P, Kalinec F. PMID: 27684094.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. HEI-OC1 cells as a model for investigating drug cytotoxicity. Hear Res. 2016 05; 335:105-117. Kalinec G, Thein P, Park C, Kalinec F. PMID: 26930622.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    9. HEI-OC1 cells as a model for investigating prestin function. Hear Res. 2016 05; 335:9-17. Park C, Thein P, Kalinec G, Kalinec F. PMID: 26854618.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Biology and pathobiology of lipid droplets and their potential role in the protection of the organ of Corti. Hear Res. 2015 Dec; 330(Pt A):26-38. Urrutia RA, Kalinec F. PMID: 25987503.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. PKCa-Mediated Signals Regulate the Motile Responses of Cochlear Outer Hair Cells. Biophys J. 2015 May 05; 108(9):2171-80. Park C, Kalinec F. PMID: 25954875.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. Hear Res. 2014 Jul; 313:26-37. Kalinec GM, Thein P, Parsa A, Yorgason J, Luxford W, Urrutia R, Kalinec F. PMID: 24793116.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    13. In vitro assessment of antiretroviral drugs demonstrates potential for ototoxicity. Hear Res. 2014 Apr; 310:27-35. Thein P, Kalinec GM, Park C, Kalinec F. PMID: 24487230.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Expression and dexamethasone-induced nuclear translocation of glucocorticoid and mineralocorticoid receptors in guinea pig cochlear cells. Hear Res. 2013 May; 299:63-78. Kil SH, Kalinec F. PMID: 23403298.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Microdomains shift and rotate in the lateral wall of cochlear outer hair cells. Biophys J. 2013 Jan 08; 104(1):8-18. Kitani R, Park C, Kalinec F. PMID: 23332054.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Deiters cells tread a narrow path--the Deiters cells-basilar membrane junction. Hear Res. 2012 Aug; 290(1-2):13-20. Parsa A, Webster P, Kalinec F. PMID: 22633942.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem. Expert Opin Drug Metab Toxicol. 2011 Dec; 7(12):1521-34. Yorgason JG, Luxford W, Kalinec F. PMID: 21999330.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Investigating outer hair cell motility with a combination of external alternating electrical field stimulation and high-speed image analysis. J Vis Exp. 2011 Jul 18; (53). Kitani R, Kalinec F. PMID: 21788937.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Motile responses of cochlear outer hair cells stimulated with an alternating electrical field. Hear Res. 2011 Oct; 280(1-2):209-18. Kitani R, Kakehata S, Kalinec F. PMID: 21664265.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. Linking LIMK1 deficiency to hyperacusis and progressive hearing loss in individuals with Williams syndrome. Commun Integr Biol. 2011 Mar; 4(2):208-10. Matsumoto N, Kitani R, Kalinec F. PMID: 21655442.
      View in: PubMed   Mentions:
    21. Pivotal role of actin depolymerization in the regulation of cochlear outer hair cell motility. Biophys J. 2010 Oct 06; 99(7):2067-76. Matsumoto N, Kitani R, Maricle A, Mueller M, Kalinec F. PMID: 20923640.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Acetaminophen ototoxicity after acetaminophen/hydrocodone abuse: evidence from two parallel in vitro mouse models. Otolaryngol Head Neck Surg. 2010 Jun; 142(6):814-9, 819.e1-2. Yorgason JG, Kalinec GM, Luxford WM, Warren FM, Kalinec F. PMID: 20493351.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. Glucocorticoid-stimulated, transcription-independent release of annexin A1 by cochlear Hensen cells. Br J Pharmacol. 2009 Dec; 158(7):1820-34. Kalinec F, Webster P, Maricle A, Guerrero D, Chakravarti DN, Chakravarti B, Gellibolian R, Kalinec G. PMID: 19912231.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Characterization of biological effect of 1763 MHz radiofrequency exposure on auditory hair cells. Int J Radiat Biol. 2008 Nov; 84(11):909-15. Huang TQ, Lee MS, Oh EH, Kalinec F, Zhang BT, Seo JS, Park WY. PMID: 19016139.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    25. Tuning in to the amazing outer hair cell: membrane wizardry with a twist and shout. J Membr Biol. 2006 Feb-Mar; 209(2-3):119-34. He DZ, Zheng J, Kalinec F, Kakehata S, Santos-Sacchi J. PMID: 16773497.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    26. Understanding drug ototoxicity: molecular insights for prevention and clinical management. Expert Opin Drug Saf. 2006 May; 5(3):383-99. Yorgason JG, Fayad JN, Kalinec F. PMID: 16610968.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    27. Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):16019-24. Kalinec GM, Fernandez-Zapico ME, Urrutia R, Esteban-Cruciani N, Chen S, Kalinec F. PMID: 16239342.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    28. Extraction of prestin-dependent and prestin-independent components from complex motile responses in guinea pig outer hair cells. Biophys J. 2005 Dec; 89(6):4343-51. Matsumoto N, Kalinec F. PMID: 16199492.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Prestin-dependent and prestin-independent motility of guinea pig outer hair cells. Hear Res. 2005 Oct; 208(1-2):1-13. Matsumoto N, Kalinec F. PMID: 16000248.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells. Hear Res. 2005 Jun; 204(1-2):127-39. So HS, Park C, Kim HJ, Lee JH, Park SY, Lee JH, Lee ZW, Kim HM, Kalinec F, Lim DJ, Park R. PMID: 15925198.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    31. A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol. 2003 Jul-Aug; 8(4):177-89. Kalinec GM, Webster P, Lim DJ, Kalinec F. PMID: 12811000.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsPHPublic Health
    32. ROCK-dependent and ROCK-independent control of cochlear outer hair cell electromotility. J Biol Chem. 2003 Sep 12; 278(37):35644-50. Zhang M, Kalinec GM, Urrutia R, Billadeau DD, Kalinec F. PMID: 12837763.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    33. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hear Res. 2002 Dec; 174(1-2):45-54. Devarajan P, Savoca M, Castaneda MP, Park MS, Esteban-Cruciani N, Kalinec G, Kalinec F. PMID: 12433395.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    34. Structural microdomains in the lateral plasma membrane of cochlear outer hair cells. J Assoc Res Otolaryngol. 2002 Sep; 3(3):289-301. Zhang M, Kalinec F. PMID: 12382104.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    35. Apoptosis in the OC-k3 immortalized cell line treated with different agents. Audiology. 2001 Nov-Dec; 40(6):327-35. Bertolaso L, Martini A, Bindini D, Lanzoni I, Parmeggiani A, Vitali C, Kalinec G, Kalinec F, Capitani S, Previati M. PMID: 11781046.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Current concept of outer hair cell motility. Auris Nasus Larynx. 2000 Oct; 27(4):349-55. Kakehata S, Dallos P, Brownell WE, Iwasa KH, Kachar B, Kalinec F, Ikeda K, Takasaka T. PMID: 10996495.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    37. Rho GTPases mediate the regulation of cochlear outer hair cell motility by acetylcholine. J Biol Chem. 2000 Sep 08; 275(36):28000-5. Kalinec F, Zhang M, Urrutia R, Kalinec G. PMID: 10862776.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    38. Establishment and characterization of conditionally immortalized organ of corti cell lines. Cell Biol Int. 1999; 23(3):175-84. Kalinec F, Kalinec G, Boukhvalova M, Kachar B. PMID: 10562438.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    39. The membrane-based mechanism of cell motility in cochlear outer hair cells. Mol Biol Cell. 1998 Aug; 9(8):1961-8. Frolenkov GI, Atzori M, Kalinec F, Mammano F, Kachar B. PMID: 9693359.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. Cell and molecular basis of hearing. Kidney Int Suppl. 1998 Apr; 65:S104-13. Lim DJ, Kalinec F. PMID: 9551442.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    41. Cochlear outer hair cell bending in an external electric field. Biophys J. 1997 Sep; 73(3):1665-72. Frolenkov GI, Kalinec F, Tavartkiladze GA, Kachar B. PMID: 9284333.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. Immunolocalization of anion exchanger 2alpha in auditory sensory hair cells. Hear Res. 1997 Aug; 110(1-2):141-6. Kalinec F, Kalinec G, Negrini C, Kachar B. PMID: 9282896.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Cloning of an organ of Corti anion exchanger 2 isoform with a truncated C-terminal domain. Biochim Biophys Acta. 1995 May 24; 1236(1):207-11. Negrini C, Rivolta MN, Kalinec F, Kachar B. PMID: 7794951.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. Inhibition of outer hair cell electromotility by sulfhydryl specific reagents. Neurosci Lett. 1993 Jul 23; 157(2):231-4. Kalinec F, Kachar B. PMID: 8233059.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. A membrane-based force generation mechanism in auditory sensory cells. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8671-5. Kalinec F, Holley MC, Iwasa KH, Lim DJ, Kachar B. PMID: 1528879.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    46. Structure of the cortical cytoskeleton in mammalian outer hair cells. J Cell Sci. 1992 Jul; 102 ( Pt 3):569-80. Holley MC, Kalinec F, Kachar B. PMID: 1506434.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    47. Ultrastructural variations of the urothelial membrane in essential fatty acid (EFA)-deficient rats. A digital densitometric study. J Histochem Cytochem. 1986 Dec; 34(12):1639-44. Kalinec F, Calderón JH, Monis B. PMID: 3782776.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. Increased proliferation of the epithelium of the proximal alimentary tract of EFA-deficient rats: a light and electron microscopy study. Exp Mol Pathol. 1982 Apr; 36(2):135-43. Eynard AR, Monis B, Kalinec F, Leguizamón RO. PMID: 7060719.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Ultrastructural changes of the luminal plasma membrane of the transitional epithelium of the rat urinary tract in essential fatty acid deficiency. Experientia. 1976 Jun 15; 32(6):697-9. Monis B, Eynard A, Lis D, Kalinec F. PMID: 950010.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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