Feng Guo

Title(s)Professor, Biological Chemistry
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Developing three-dimensional antisense oligonucleotide drugs against COVID-19
    NIH R01AI163216Jul 19, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Molecular recognition and regulation in microRNA processing by the DGCR8 protein
    NIH R01GM080563Aug 10, 2007 - Nov 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 2023 04 25; 14(1):2379. Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. PMID: 37185252; PMCID: PMC10127185.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication. bioRxiv. 2021 Aug 24. Li Y, Garcia G, Arumugaswami V, Guo F. PMID: 34462746; PMCID: PMC8404888.
      View in: PubMed   Mentions: 2  
    3. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure. 2018 09 04; 26(9):1275-1283.e3. Shoffner GM, Wang R, Podell E, Cech TR, Guo F. PMID: 29910185; PMCID: PMC6125213.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. Pyridine Hemochromagen Assay for Determining the Concentration of Heme in Purified Protein Solutions. Bio Protoc. 2015; 5(18). Barr I, Guo F. PMID: 27390766; PMCID: PMC4932910.
      View in: PubMed   Mentions: 38  
    5. Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chem Biol. 2015 Jun 18; 22(6):793-802. Barr I, Weitz SH, Atkin T, Hsu P, Karayiorgou M, Gogos JA, Weiss S, Guo F. PMID: 26091172; PMCID: PMC4788496.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Rep. 2014 Jun 26; 7(6):1994-2005. Quick-Cleveland J, Jacob JP, Weitz SH, Shoffner G, Senturia R, Guo F. PMID: 24910438; PMCID: PMC4133150.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    7. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. PMID: 24828042; PMCID: PMC4263271.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimalsCells
    8. Processing of microRNA primary transcripts requires heme in mammalian cells. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1861-6. Weitz SH, Gong M, Barr I, Weiss S, Guo F. PMID: 24449907; PMCID: PMC3918773.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    9. Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8. Methods Mol Biol. 2014; 1095:73-86. Barr I, Guo F. PMID: 24166303; PMCID: PMC4788497.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. PLoS One. 2012; 7(7):e39688. Senturia R, Laganowsky A, Barr I, Scheidemantle BD, Guo F. PMID: 22768307; PMCID: PMC3388087.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8. Protein Sci. 2012 Jun; 21(6):797-808. Gong M, Chen Y, Senturia R, Ulgherait M, Faller M, Guo F. PMID: 22434730; PMCID: PMC3403415.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. Identification of a cis-acting element that localizes mRNA to synapses. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4639-44. Meer EJ, Wang DO, Kim S, Barr I, Guo F, Martin KC. PMID: 22383561; PMCID: PMC3311331.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    13. Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1919-24. Barr I, Smith AT, Chen Y, Senturia R, Burstyn JN, Guo F. PMID: 22308374; PMCID: PMC3277547.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    14. Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon. Protein Sci. 2011 Jul; 20(7):1231-43. Januszyk K, Fleissner MR, Atchabahian L, Shieh FK, Altenbach C, Martin SL, Guo F, Hubbell WL, Clubb RT. PMID: 21563223; PMCID: PMC3149196.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein. J Biol Chem. 2011 May 13; 286(19):16716-25. Barr I, Smith AT, Senturia R, Chen Y, Scheidemantle BD, Burstyn JN, Guo F. PMID: 21454614; PMCID: PMC3089513.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    16. Structure of the dimerization domain of DiGeorge critical region 8. Protein Sci. 2010 Jul; 19(7):1354-65. Senturia R, Faller M, Yin S, Loo JA, Cascio D, Sawaya MR, Hwang D, Clubb RT, Guo F. PMID: 20506313; PMCID: PMC2974827.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    17. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA. 2010 Aug; 16(8):1570-83. Faller M, Toso D, Matsunaga M, Atanasov I, Senturia R, Chen Y, Zhou ZH, Guo F. PMID: 20558544; PMCID: PMC2905756.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    18. Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene. RNA. 2008 Dec; 14(12):2478-88. Wang Q, Barr I, Guo F, Lee C. PMID: 18974280; PMCID: PMC2590956.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    19. Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem. 2009 Jan 02; 284(1):276-283. Miallau L, Faller M, Chiang J, Arbing M, Guo F, Cascio D, Eisenberg D. PMID: 18952600; PMCID: PMC2610494.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    20. MicroRNA biogenesis: there's more than one way to skin a cat. Biochim Biophys Acta. 2008 Nov; 1779(11):663-7. Faller M, Guo F. PMID: 18778799; PMCID: PMC2633599.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    21. Heme is involved in microRNA processing. Nat Struct Mol Biol. 2007 Jan; 14(1):23-9. Faller M, Matsunaga M, Yin S, Loo JA, Guo F. PMID: 17159994.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansCells
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