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Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex. JCI Insight. 2022 04 22; 7(8).
Zhang R, Kumar GS, Hansen U, Zoccheddu M, Sacchetti C, Holmes ZJ, Lee MC, Beckmann D, Wen Y, Mikulski Z, Yang S, Santelli E, Page R, Boin F, Peti W, Bottini N. PMID: 35451370; PMCID: PMC9089796.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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The prognostic role of matrix metalloproteinase-7 in scleroderma-associated interstitial lung disease. Eur Respir J. 2021 12; 58(6).
Matson SM, Lee SJ, Peterson RA, Achtar-Zadeh NA, Boin F, Wolters PJ, Lee JS. PMID: 34588190; PMCID: PMC9724002.
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PubMed Mentions: Fields:
Translation:
Humans
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Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis. Thorax. 2021 12; 76(12):1186-1192.
Liu S, Chung MP, Ley B, French S, Elicker BM, Fiorentino DF, Chung LS, Boin F, Wolters PJ. PMID: 34272332; PMCID: PMC9262637.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Autoantibodies targeting telomere-associated proteins in systemic sclerosis. Ann Rheum Dis. 2021 07; 80(7):912-919.
Adler BL, Boin F, Wolters PJ, Bingham CO, Shah AA, Greider C, Casciola-Rosen L, Rosen A. PMID: 33495152; PMCID: PMC8217217.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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The Utility of Plasma Vascular Biomarkers in Systemic Sclerosis: A Prospective Longitudinal Analysis. Arthritis Rheumatol. 2020 08; 72(8):1341-1349.
Mecoli CA, Shah AA, Boin F, Wigley FM, Hummers LK. PMID: 32200572; PMCID: PMC8214152.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. Arthritis Rheumatol. 2020 08; 72(8):1375-1384.
Tiniakou E, Fava A, McMahan ZH, Guhr T, O'Meally RN, Shah AA, Wigley FM, Cole RN, Boin F, Darrah E. PMID: 32162841; PMCID: PMC7486267.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Clinical and Molecular Phenotyping in Scleromyxedema Pretreatment and Posttreatment With Intravenous Immunoglobulin. Arthritis Care Res (Hoboken). 2020 06; 72(6):761-767.
Mecoli CA, Talbot CC, Fava A, Cheadle C, Boin F, Wigley FM, Hummers LK. PMID: 31008568; PMCID: PMC6810715.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Longitudinal assessment of interstitial lung disease in single lung transplant recipients with scleroderma. Rheumatology (Oxford). 2020 04 01; 59(4):790-798.
Hinze AM, Lin CT, Hussien AF, Perin J, Venado A, Golden JA, Boin F, Brown RH, Wise RA, Wigley FM. PMID: 31504916; PMCID: PMC7188227.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Heart-lung transplantation: A viable option for connective tissue diseases. Clin Transplant. 2020 02; 34(2):e13776.
Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. PMID: 31867763.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):552-562.
Gourh P, Safran SA, Alexander T, Boyden SE, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA, Ramos PS, Silver RM, Steen VD, Varga J, Hsu V, Saketkoo LA, Schiopu E, Khanna D, Gordon JK, Kron B, Criswell LA, Gladue H, Derk CT, Bernstein EJ, Bridges SL, Shanmugam VK, Kolstad KD, Chung L, Kafaja S, Jan R, Trojanowski M, Goldberg A, Korman BD, Steinbach PJ, Chandrasekharappa SC, Mullikin JC, Adeyemo A, Rotimi C, Wigley FM, Kastner DL, Boin F, Remmers EF. PMID: 31871193; PMCID: PMC6955366.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses. Sci Immunol. 2019 09 06; 4(39).
Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD. PMID: 31492709; PMCID: PMC6848056.
View in:
PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol. 2018 10; 70(10):1654-1660.
Gourh P, Remmers EF, Boyden SE, Alexander T, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA, Steen VD, Ramos PS, Silver RM, Korman B, Varga J, Schiopu E, Khanna D, Hsu V, Gordon JK, Saketkoo LA, Gladue H, Kron B, Criswell LA, Derk CT, Bridges SL, Shanmugam VK, Kolstad KD, Chung L, Jan R, Bernstein EJ, Goldberg A, Trojanowski M, Kafaja S, Maksimowicz-McKinnon KM, Mullikin JC, Adeyemo A, Rotimi C, Boin F, Kastner DL, Wigley FM. PMID: 29732714; PMCID: PMC6160338.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Vascular complications in systemic sclerosis: a prospective cohort study. Clin Rheumatol. 2018 Sep; 37(9):2429-2437.
Mecoli CA, Shah AA, Boin F, Wigley FM, Hummers LK. PMID: 29804150; PMCID: PMC6166238.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Patient-reported outcome instruments for assessing Raynaud's phenomenon in systemic sclerosis: A SCTC Vascular Working Group Report. J Scleroderma Relat Disord. 2018 Oct; 3(3):249-252.
Pauling JD, Frech TM, Hughes M, Gordon JK, Domsic RT, Anderson ME, Ingegnoli F, McHugh NJ, Johnson SR, Hudson M, Boin F, Ong VH, Matucci-Cerinic M, Altorok N, Scolnik M, Nikpour M, Shah A, Pope JE, Khanna D, Herrick AL. PMID: 30705970; PMCID: PMC6350902.
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PubMed Mentions:
10
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Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. Medicine (Baltimore). 2017 Dec; 96(51):e8980.
Morgan ND, Shah AA, Mayes MD, Domsic RT, Medsger TA, Steen VD, Varga J, Carns M, Ramos PS, Silver RM, Schiopu E, Khanna D, Hsu V, Gordon JK, Gladue H, Saketkoo LA, Criswell LA, Derk CT, Trojanowski MA, Shanmugam VK, Chung L, Valenzuela A, Jan R, Goldberg A, Remmers EF, Kastner DL, Wigley FM, Gourh P, Boin F. PMID: 29390428; PMCID: PMC5758130.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Flow cytometric discrimination of seven lineage markers by using two fluorochromes. PLoS One. 2017; 12(11):e0188916.
Boin F, Giardino Torchia ML, Borrello I, Noonan KA, Neil M, Soloski MJ, Cimbro R. PMID: 29190813; PMCID: PMC5708788.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 10 20; 8(1):1060.
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. PMID: 29057934; PMCID: PMC5651906.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model. Chest. 2017 11; 152(5):999-1007.
Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters PJ, King TE, Collard HR, Lee JS. PMID: 28629914; PMCID: PMC5812750.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Lung Transplantation in Patients With Systemic Sclerosis. Curr Rheumatol Rep. 2017 May; 19(5):23.
Shah RJ, Boin F. PMID: 28386760.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity. JCI Insight. 2016 Dec 22; 1(21):e89073.
Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P. PMID: 28018971; PMCID: PMC5161207.
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PubMed Mentions:
40 Fields:
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Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma. Arthritis Res Ther. 2016 05 04; 18(1):99.
Fava A, Cimbro R, Wigley FM, Liu QR, Rosen A, Boin F. PMID: 27145754; PMCID: PMC4857293.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Association of Acroosteolysis With Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis. Arthritis Rheumatol. 2016 Jan; 68(1):201-9.
Park JK, Fava A, Carrino J, Del Grande F, Rosen A, Boin F. PMID: 26361270; PMCID: PMC4690758.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Spectrum of Muscle Histopathologic Findings in Forty-Two Scleroderma Patients With Weakness. Arthritis Care Res (Hoboken). 2015 Oct; 67(10):1416-25.
Paik JJ, Wigley FM, Lloyd TE, Corse AM, Casciola-Rosen L, Shah AA, Boin F, Hummers LK, Mammen AL. PMID: 25989455; PMCID: PMC4580502.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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A methodology for exploring biomarker--phenotype associations: application to flow cytometry data and systemic sclerosis clinical manifestations. BMC Bioinformatics. 2015 Sep 15; 16:293.
Huang H, Fava A, Guhr T, Cimbro R, Rosen A, Boin F, Ellis H. PMID: 26373409; PMCID: PMC4571079.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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The role of the acquired immune response in systemic sclerosis. Semin Immunopathol. 2015 Sep; 37(5):519-28.
Chizzolini C, Boin F. PMID: 26152639.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Intravenous immunoglobulin may be an effective therapy for refractory, active diffuse cutaneous systemic sclerosis. J Rheumatol. 2015 Feb; 42(2):236-42.
Poelman CL, Hummers LK, Wigley FM, Anderson C, Boin F, Shah AA. PMID: 25433527; PMCID: PMC4314512.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension. Orphanet J Rare Dis. 2014 Aug 01; 9:123.
Boin F, Erre GL, Posadino AM, Cossu A, Giordo R, Spinetti G, Passiu G, Emanueli C, Pintus G. PMID: 25085432; PMCID: PMC4237898.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science. 2014 Jan 10; 343(6167):152-7.
Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, Boin F, Fava A, Thoburn C, Kinde I, Jiao Y, Papadopoulos N, Kinzler KW, Vogelstein B, Rosen A. PMID: 24310608; PMCID: PMC4038033.
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PubMed Mentions:
170 Fields:
Translation:
HumansCells
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Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature. Medicine (Baltimore). 2013 Jul; 92(4):191-205.
Gelber AC, Manno RL, Shah AA, Woods A, Le EN, Boin F, Hummers LK, Wigley FM. PMID: 23793108; PMCID: PMC4553970.
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PubMed Mentions:
42 Fields:
Translation:
Humans
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The degree of skin involvement identifies distinct lung disease outcomes and survival in systemic sclerosis. Ann Rheum Dis. 2014 Jun; 73(6):1060-6.
Cottrell TR, Wise RA, Wigley FM, Boin F. PMID: 23606705; PMCID: PMC4776325.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion. Arthritis Res Ther. 2013 Apr 18; 15(2):R54.
Shah AA, Schiopu E, Hummers LK, Wade M, Phillips K, Anderson C, Wise R, Boin F, Seibold JR, Wigley F, Rollins KD. PMID: 23597147; PMCID: PMC5011881.
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PubMed Mentions:
7 Fields:
Translation:
HumansCTClinical Trials
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Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon. Arthritis Care Res (Hoboken). 2012 Jun; 64(6):925-9.
Fava A, Wung PK, Wigley FM, Hummers LK, Daya NR, Ghazarian SR, Boin F. PMID: 22275160; PMCID: PMC3343172.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease. Ann Rheum Dis. 2011 Dec; 70(12):2218-24.
Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. PMID: 21873333; PMCID: PMC3409247.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Long-term experience of mycophenolate mofetil for treatment of diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2011 Jun; 70(6):1104-7.
Le EN, Wigley FM, Shah AA, Boin F, Hummers LK. PMID: 21378404; PMCID: PMC3828653.
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PubMed Mentions:
31 Fields:
Translation:
Humans
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Immunotherapy of systemic sclerosis. Immunotherapy. 2010 Nov; 2(6):863-78.
Manno R, Boin F. PMID: 21091117; PMCID: PMC3059511.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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The "tank top sign": a unique pattern of skin fibrosis seen in pansclerotic morphea. Ann Rheum Dis. 2009 Sep; 68(9):1511-2.
Sherber NS, Boin F, Hummers LK, Wigley FM. PMID: 19674989.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Resolution of pansclerotic morphea after treatment with antithymocyte globulin. Nat Rev Rheumatol. 2009 Sep; 5(9):513-6.
Song P, Gocke C, Wigley FM, Boin F. PMID: 19710673.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Independent association of anti-beta(2)-glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients. Arthritis Rheum. 2009 Aug; 60(8):2480-9.
Boin F, Franchini S, Colantuoni E, Rosen A, Wigley FM, Casciola-Rosen L. PMID: 19644882; PMCID: PMC2746063.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Connective tissue diseases: Immunosuppressive therapy in SSc: what is the target? Nat Rev Rheumatol. 2009 Jul; 5(7):357-8.
Boin F, Wigley F. PMID: 19568247.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera. Arthritis Rheum. 2009 Apr; 60(4):1145-51.
Loizos N, Lariccia L, Weiner J, Griffith H, Boin F, Hummers L, Wigley F, Kussie P. PMID: 19333919.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease. Arthritis Rheum. 2008 Apr; 58(4):1165-74.
Boin F, De Fanis U, Bartlett SJ, Wigley FM, Rosen A, Casolaro V. PMID: 18383361; PMCID: PMC2662772.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Scleroderma-like fibrosing disorders. Rheum Dis Clin North Am. 2008 Feb; 34(1):199-220; ix.
Boin F, Hummers LK. PMID: 18329541; PMCID: PMC2706095.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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Autoimmunity in systemic sclerosis: current concepts. Curr Rheumatol Rep. 2007 May; 9(2):165-72.
Boin F, Rosen A. PMID: 17502048.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Churg-Strauss syndrome presenting with salivary gland enlargement and respiratory distress. Arthritis Rheum. 2006 Feb 15; 55(1):167-70.
Boin F, Sciubba JJ, Stone JH. PMID: 16463394.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis. Ann N Y Acad Sci. 2005 Dec; 1062:137-45.
Boin F, Wigley FM, Schneck JP, Oelke M, Rosen A. PMID: 16461796.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Understanding, assessing and treating Raynaud's phenomenon. Curr Opin Rheumatol. 2005 Nov; 17(6):752-60.
Boin F, Wigley FM. PMID: 16224254.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia. Biol Psychiatry. 2002 Mar 15; 51(6):480-4.
Bocchio Chiavetto L, Boin F, Zanardini R, Popoli M, Michelato A, Bignotti S, Tura GB, Gennarelli M. PMID: 11922883.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry. 2001 Jan; 6(1):79-82.
Boin F, Zanardini R, Pioli R, Altamura CA, Maes M, Gennarelli M. PMID: 11244489.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Effects of atypical antipsychotics on the inflammatory response system in schizophrenic patients resistant to treatment with typical neuroleptics. Eur Neuropsychopharmacol. 2000 Mar; 10(2):119-24.
Maes M, Bocchio Chiavetto L, Bignotti S, Battisa Tura G, Pioli R, Boin F, Kenis G, Bosmans E, de Jongh R, Lin A, Racagni G, Altamura CA. PMID: 10706993.
View in:
PubMed Mentions:
45 Fields:
Translation:
Humans