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Genomic annotation and molecular evolution of monkeypox virus outbreak in 2022. J Med Virol. 2023 01; 95(1):e28036.
Wang L, Shang J, Weng S, Aliyari SR, Ji C, Cheng G, Wu A. PMID: 35906185; PMCID: PMC10087776.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Potential intervariant and intravariant recombination of Delta and Omicron variants. J Med Virol. 2022 10; 94(10):4830-4838.
Wang L, Zhou HY, Li JY, Cheng YX, Zhang S, Aliyari S, Wu A, Cheng G. PMID: 35705528; PMCID: PMC9350351.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1. Cell Mol Immunol. 2022 08; 19(8):872-882.
Zhang S, Wang J, Wang L, Aliyari S, Cheng G. PMID: 35732914; PMCID: PMC9217730.
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PubMed Mentions:
7 Fields:
Translation:
HumansCellsPHPublic Health
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The Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2. Pathogens. 2022 May 03; 11(5).
Aliyari SR, Quanquin N, Pernet O, Zhang S, Wang L, Cheng G. PMID: 35631059; PMCID: PMC9147806.
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PubMed Mentions:
2
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Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2. Acta Pharm Sin B. 2022 Apr; 12(4):1624-1635.
Aliyari SR, Ghaffari AA, Pernet O, Parvatiyar K, Wang Y, Gerami H, Tong AJ, Vergnes L, Takallou A, Zhang A, Wei X, Chilin LD, Wu Y, Semenkovich CF, Reue K, Smale ST, Lee B, Cheng G. PMID: 35251918; PMCID: PMC8883762.
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PubMed Mentions:
3
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The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies. Mol Ther. 2022 05 04; 30(5):1869-1884.
Zhang S, Wang L, Cheng G. PMID: 35176485; PMCID: PMC8842579.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Sequence analysis of the emerging SARS-CoV-2 variant Omicron in South Africa. J Med Virol. 2022 04; 94(4):1728-1733.
Wang L, Cheng G. PMID: 34897752.
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PubMed Mentions:
105 Fields:
Translation:
HumansCells
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Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications. Sci Adv. 2021 Sep 17; 7(38):eabf2073.
López-Aranda MF, Chattopadhyay I, Boxx GM, Fraley ER, Silva TK, Zhou M, Phan M, Herrera I, Taloma S, Mandanas R, Bach K, Gandal M, Geschwind DH, Cheng G, Rzhetsky A, White SA, Silva AJ. PMID: 34533985; PMCID: PMC8448451.
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PubMed Mentions:
2 Fields:
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Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).
Zhang S, Wang J, Cheng G. PMID: 34452991; PMCID: PMC8449311.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Gravidity-dependent associations between interferon response and birth weight in placental malaria. Malar J. 2020 Aug 05; 19(1):280.
Quanquin NM, Barres LG, Aliyari SR, Day NT, Gerami H, Fisher SJ, Kakuru A, Kamya MR, Havlir DV, Feeney M, Dorsey G, Cheng G, Gaw SL. PMID: 32758231; PMCID: PMC7409479.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Comprehensive Mutagenesis of Herpes Simplex Virus 1 Genome Identifies UL42 as an Inhibitor of Type I Interferon Induction. J Virol. 2019 12 01; 93(23).
Chapon M, Parvatiyar K, Aliyari SR, Zhao JS, Cheng G. PMID: 31511375; PMCID: PMC6854482.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses. Antimicrob Agents Chemother. 2019 Sep 16.
Li C, Zu S, Deng YQ, Li D, Parvatiyar K, Quanquin N, Shang J, Sun N, Su J, Liu Z, Wang M, Aliyari SR, Li XF, Wu A, Ma F, Shi Y, Nielsevn-Saines K, Jung JU, Qin FX, Qin CF, Cheng G. PMID: 31527024; PMCID: PMC6879226.
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PubMed Mentions:
54 Fields:
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Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children. Nat Med. 2019 08; 25(8):1213-1217.
Nielsen-Saines K, Brasil P, Kerin T, Vasconcelos Z, Gabaglia CR, Damasceno L, Pone M, Abreu de Carvalho LM, Pone SM, Zin AA, Tsui I, Salles TRS, da Cunha DC, Costa RP, Malacarne J, Reis AB, Hasue RH, Aizawa CYP, Genovesi FF, Einspieler C, Marschik PB, Pereira JP, Gaw SL, Adachi K, Cherry JD, Xu Z, Cheng G, Moreira ME. PMID: 31285631; PMCID: PMC6689256.
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PubMed Mentions:
95 Fields:
Translation:
HumansCells
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Impact of antimalarial (AM) on serum lipids in systemic lupus erythematosus (SLE) patients: A systematic review and meta-analysis. Medicine (Baltimore). 2019 Apr; 98(14):e15030.
Tao CY, Shang J, Chen T, Yu D, Jiang YM, Liu D, Cheng GY, Xiao J, Zhao ZZ. PMID: 30946340; PMCID: PMC6456110.
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PubMed Mentions:
5 Fields:
Translation:
Humans
-
The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation. Radiat Res. 2019 04; 191(4):323-334.
Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. PMID: 30730284; PMCID: PMC6482953.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsPHPublic Health
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Transcatheter Closure of Perimembranous Ventricular Septal Defects in Children using a Wire-Drifting Technique. Clinics (Sao Paulo). 2018 11 29; 73:e371.
He L, Cheng GS, Zhang YS, He XM, Wang XY, Du YJ. PMID: 30517278; PMCID: PMC6238823.
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PubMed Mentions: Fields:
Translation:
Humans
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A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. Nat Commun. 2018 07 17; 9(1):2770.
Parvatiyar K, Pindado J, Dev A, Aliyari SR, Zaver SA, Gerami H, Chapon M, Ghaffari AA, Dhingra A, Cheng G. PMID: 30018345; PMCID: PMC6050272.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532.
Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. PMID: 29020636; PMCID: PMC5637483.
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PubMed Mentions:
148 Fields:
Translation:
HumansCells
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9,19-Cycloartenol glycoside G3 from Cimicifuga simplex regulates immune responses by modulating Th17/Treg ratio. Bioorg Med Chem. 2017 09 01; 25(17):4917-4923.
Su Y, Wu L, Mu G, Wang Q, Yang B, Cheng G, Kuang H. PMID: 28780985.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues. PLoS One. 2017; 12(7):e0181577.
Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. PMID: 28732024; PMCID: PMC5521796.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCellsPHPublic Health
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Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease. World J Gastroenterol. 2017 Apr 21; 23(15):2771-2784.
Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY. PMID: 28487615; PMCID: PMC5403757.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host Microbe. 2017 Mar 08; 21(3):334-343.
Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX, Cheng G. PMID: 28279345.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Potential for treatment and a Zika virus vaccine. Curr Opin Pediatr. 2017 02; 29(1):114-121.
Quanquin N, Wang L, Cheng G. PMID: 27906864; PMCID: PMC5963532.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The Roles of Type I Interferon in Bacterial Infection. Cell Host Microbe. 2016 Jun 08; 19(6):760-9.
Boxx GM, Cheng G. PMID: 27281568; PMCID: PMC5847370.
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PubMed Mentions:
133 Fields:
Translation:
HumansAnimalsCells
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Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons. PLoS Pathog. 2016 05; 12(5):e1005572.
Deriu E, Boxx GM, He X, Pan C, Benavidez SD, Cen L, Rozengurt N, Shi W, Cheng G. PMID: 27149619; PMCID: PMC4858270.
View in:
PubMed Mentions:
118 Fields:
Translation:
Animals
-
From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe. 2016 May 11; 19(5):561-5.
Wang L, Valderramos SG, Wu A, Ouyang S, Li C, Brasil P, Bonaldo M, Coates T, Nielsen-Saines K, Jiang T, Aliyari R, Cheng G. PMID: 27091703; PMCID: PMC5648540.
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PubMed Mentions:
111 Fields:
Translation:
HumansAnimalsCells
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Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase. J Virol. 2015 Dec 30; 90(6):2938-47.
Wang L, Wu A, Wang YE, Quanquin N, Li C, Wang J, Chen HW, Liu S, Liu P, Zhang H, Qin FX, Jiang T, Cheng G. PMID: 26719244; PMCID: PMC4810648.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol. 2015 Oct; 135(10):2410-2417.
Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL. PMID: 26030183; PMCID: PMC4567935.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS. J Immunol. 2015 Feb 15; 194(4):1545-54.
Ma F, Li B, Liu SY, Iyer SS, Yu Y, Wu A, Cheng G. PMID: 25609843; PMCID: PMC4324085.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Positive feedback regulation of type I interferon by the interferon-stimulated gene STING. EMBO Rep. 2015 Feb; 16(2):202-12.
Ma F, Li B, Yu Y, Iyer SS, Sun M, Cheng G. PMID: 25572843; PMCID: PMC4328747.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Radiation and inflammation. Semin Radiat Oncol. 2015 Jan; 25(1):4-10.
Schaue D, Micewicz ED, Ratikan JA, Xie MW, Cheng G, McBride WH. PMID: 25481260; PMCID: PMC4378687.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansPHPublic Health
-
TRAF protein function in noncanonical NF-κB signaling. Methods Mol Biol. 2015; 1280:247-68.
Reichardt AD, Pindado J, Zaver SA, Cheng G. PMID: 25736753.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon. Nat Commun. 2014 Nov 24; 5:5494.
Ma F, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, Núñez V, Ricote M, Cheng G. PMID: 25417649; PMCID: PMC4380327.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Glycyrrhizic acid in the treatment of liver diseases: literature review. Biomed Res Int. 2014; 2014:872139.
Li JY, Cao HY, Liu P, Cheng GH, Sun MY. PMID: 24963489; PMCID: PMC4052927.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansAnimals
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Expression of Bcl-2 and NF-κB in brain tissue after acute renal ischemia-reperfusion in rats. Asian Pac J Trop Med. 2014 May; 7(5):386-9.
Zhang N, Cheng GY, Liu XZ, Zhang FJ. PMID: 25063066.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4904-12.
Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. PMID: 24191014; PMCID: PMC3864319.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology. 2013 Jul; 58(1):351-62.
Kamo N, Ke B, Ghaffari AA, Shen XD, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 23408710; PMCID: PMC3679353.
View in:
PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013 Apr 12; 340(6129):202-7.
Wilson EB, Yamada DH, Elsaesser H, Herskovitz J, Deng J, Cheng G, Aronow BJ, Karp CL, Brooks DG. PMID: 23580528; PMCID: PMC3704950.
View in:
PubMed Mentions:
404 Fields:
Translation:
AnimalsCells
-
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science. 2013 Mar 22; 339(6126):1448-53.
Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL. PMID: 23449998; PMCID: PMC3653587.
View in:
PubMed Mentions:
205 Fields:
Translation:
HumansCells
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Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity. 2013 Jan 24; 38(1):92-105.
Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G. PMID: 23273844; PMCID: PMC3698975.
View in:
PubMed Mentions:
296 Fields:
Translation:
HumansAnimalsCells
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Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog. 2012; 8(11):e1003047.
Cho JS, Guo Y, Ramos RI, Hebroni F, Plaisier SB, Xuan C, Granick JL, Matsushima H, Takashima A, Iwakura Y, Cheung AL, Cheng G, Lee DJ, Simon SI, Miller LS. PMID: 23209417; PMCID: PMC3510260.
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PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol. 2012 Dec; 13(12):1155-61.
Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. PMID: 23142775; PMCID: PMC3501571.
View in:
PubMed Mentions:
196 Fields:
Translation:
HumansAnimalsCells
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Detection of single influenza viral RNA in cells using a polymeric sequence probe. Anal Chem. 2012 Oct 02; 84(19):8118-21.
Huang S, Yu C, Cheng G, Chen Y. PMID: 22978816; PMCID: PMC4111224.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria. PLoS One. 2012; 7(9):e41879.
Tian X, Xu F, Lung WY, Meyerson C, Ghaffari AA, Cheng G, Deng JC. PMID: 22962579; PMCID: PMC3433467.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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[Incidence of metabolic syndrome in systemic lupus erythematosus and its influence by glucocorticoids]. Zhonghua Nei Ke Za Zhi. 2012 Jun; 51(6):441-4.
Liu SY, Guo JY, Zhang L, Liu ZS, Zheng ZH, Cheng GY, Gao GM, Zhang X, Liu GZ, Zeng XF. PMID: 22943753.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity. Int J Nanomedicine. 2012; 7:2281-92.
Ding X, Sanchez DJ, Shahangian A, Al-Shyoukh I, Cheng G, Ho CM. PMID: 22654513; PMCID: PMC3363951.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med. 2012 Mar 25; 18(4):555-63.
Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. PMID: 22447076; PMCID: PMC3348859.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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Systematic identification of type I and type II interferon-induced antiviral factors. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4239-44.
Liu SY, Sanchez DJ, Aliyari R, Lu S, Cheng G. PMID: 22371602; PMCID: PMC3306696.
View in:
PubMed Mentions:
240 Fields:
Translation:
HumansAnimalsCells
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Non-canonical NF-κB signaling activation and regulation: principles and perspectives. Immunol Rev. 2011 Nov; 244(1):44-54.
Razani B, Reichardt AD, Cheng G. PMID: 22017430.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
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Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12; 3(104):104ra102.
Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. PMID: 21998409; PMCID: PMC3269210.
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PubMed Mentions:
250 Fields:
Translation:
HumansCells
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Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo. J Biol Chem. 2011 Oct 28; 286(43):37077-84.
Liu Y, Tian X, Leitner WW, Aldridge ME, Zheng J, Yu Z, Restifo NP, Weiss R, Scheiblhofer S, Xie C, Sun R, Cheng G, Zeng G. PMID: 21900253; PMCID: PMC3199455.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 2011 Nov; 141(5):1852-63.e1-3.
Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C. PMID: 21762664; PMCID: PMC3199285.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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NOD so fast: NLRX1 puts the brake on inflammation. Immunity. 2011 Jun 24; 34(6):821-2.
Parvatiyar K, Cheng G. PMID: 21703534; PMCID: PMC4061909.
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PubMed Mentions:
8 Fields:
-
Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3. Hepatology. 2011 Jun; 53(6):2042-52.
Ghaffari AA, Chow EK, Iyer SS, Deng JC, Cheng G. PMID: 21433044; PMCID: PMC3103596.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge. Cell Res. 2011 Jul; 21(7):1068-79.
Pietras EM, Miller LS, Johnson CT, O'Connell RM, Dempsey PW, Cheng G. PMID: 21467996; PMCID: PMC3193491.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1. PLoS One. 2011 Feb 25; 6(2):e17310.
Tricker E, Arvand A, Kwan R, Chen GY, Gallagher E, Cheng G. PMID: 21364884; PMCID: PMC3045432.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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tuberculosis detection via rolling circle amplification. Anal Methods. 2011 Feb 01; 3(2):267-273.
Schopf E, Liu Y, Deng JC, Yang S, Cheng G, Chen Y. PMID: 32938023.
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PubMed Mentions:
2 Fields:
-
NF-κB and innate immunity. Curr Top Microbiol Immunol. 2011; 349:115-43.
Dev A, Iyer S, Razani B, Cheng G. PMID: 20848362.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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New developments in the induction and antiviral effectors of type I interferon. Curr Opin Immunol. 2011 Feb; 23(1):57-64.
Liu SY, Sanchez DJ, Cheng G. PMID: 21123041; PMCID: PMC3822007.
View in:
PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. J Immunol. 2010 Dec 01; 185(11):6599-607.
Iyer SS, Ghaffari AA, Cheng G. PMID: 21041726; PMCID: PMC4103176.
View in:
PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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NF-kappaB: much learned, much to learn. Sci Signal. 2010 Sep 07; 3(138):pe29.
Razani B, Cheng G. PMID: 20823402.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci Signal. 2010 May 25; 3(123):ra41.
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G. PMID: 20501937; PMCID: PMC2913610.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
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IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010 May; 120(5):1762-73.
Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS. PMID: 20364087; PMCID: PMC2860944.
View in:
PubMed Mentions:
309 Fields:
Translation:
AnimalsCells
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Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res. 2010 Apr 01; 70(7):2595-603.
Chin AI, Miyahira AK, Covarrubias A, Teague J, Guo B, Dempsey PW, Cheng G. PMID: 20233880; PMCID: PMC2995454.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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TRAF-mediated regulation of immune and inflammatory responses. Sci China Life Sci. 2010 Feb; 53(2):159-68.
Wang Y, Zhang P, Liu Y, Cheng G. PMID: 20596822.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009 Oct 22; 6(4):343-53.
Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. PMID: 19837374; PMCID: PMC2764558.
View in:
PubMed Mentions:
89 Fields:
Translation:
HumansCells
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Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest. 2009 Jul; 119(7):1910-20.
Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC. PMID: 19487810; PMCID: PMC2701856.
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PubMed Mentions:
275 Fields:
Translation:
AnimalsCells
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Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One. 2009 Jun 05; 4(6):e5810.
Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL. PMID: 19503839; PMCID: PMC2686169.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host Microbe. 2009 Feb 19; 5(2):166-78.
Hwang S, Kim KS, Flano E, Wu TT, Tong LM, Park AN, Song MJ, Sanchez DJ, O'Connell RM, Cheng G, Sun R. PMID: 19218087; PMCID: PMC2749518.
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PubMed Mentions:
92 Fields:
Translation:
AnimalsCells
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TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections. J Immunol. 2009 Feb 15; 182(4):2248-57.
Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G. PMID: 19201879; PMCID: PMC2656676.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol. 2008 Dec; 9(12):1371-8.
Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, Shiba T, Yang X, Yeh WC, Mak TW, Korneluk RG, Cheng G. PMID: 18997794; PMCID: PMC2676931.
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PubMed Mentions:
328 Fields:
Translation:
AnimalsCells
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A New TRADDition in intracellular antiviral signaling. Sci Signal. 2008 Jul 29; 1(30):pe36.
Pietras EM, Cheng G. PMID: 18664658.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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With a little help from my friends: modulation of phagocytosis through TLR activation. Cell Res. 2008 Jul; 18(7):711-2.
Tricker E, Cheng G. PMID: 18596701.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest. 2008 May; 118(5):1680-90.
Guo B, Chang EY, Cheng G. PMID: 18382764; PMCID: PMC2276397.
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PubMed Mentions:
184 Fields:
Translation:
AnimalsCells
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New tricks for old NODs. Genome Biol. 2008 Apr 25; 9(4):217.
Pietras EM, Cheng G. PMID: 18466630; PMCID: PMC2643928.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation. 2008 Apr 15; 85(7):1016-22.
Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW. PMID: 18408583.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol. 2008 Apr 01; 180(7):4629-38.
Velázquez P, Wei B, McPherson M, Mendoza LM, Nguyen SL, Turovskaya O, Kronenberg M, Huang TT, Schrage M, Lobato LN, Fujiwara D, Brewer S, Arditi M, Cheng G, Sartor RB, Newberry RD, Braun J. PMID: 18354186; PMCID: PMC2683842.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3503-8.
Zarnegar B, Yamazaki S, He JQ, Cheng G. PMID: 18292232; PMCID: PMC2265190.
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PubMed Mentions:
111 Fields:
Translation:
AnimalsCells
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Copolymeric nanofilm platform for controlled and localized therapeutic delivery. ACS Nano. 2008 Jan; 2(1):33-40.
Chow EK, Pierstorff E, Cheng G, Ho D. PMID: 19206545.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15; 179(12):8128-36.
Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. PMID: 18056355; PMCID: PMC2650749.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. J Virol. 2008 Mar; 82(5):2208-17.
Sanchez DJ, Miranda D, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G. PMID: 18077715; PMCID: PMC2258961.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol. 2007 Nov 15; 179(10):6933-42.
Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL. PMID: 17982084.
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PubMed Mentions:
170 Fields:
Translation:
AnimalsCells
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IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production. J Biol Chem. 2008 Jan 11; 283(2):802-8.
Oganesyan G, Saha SK, Pietras EM, Guo B, Miyahira AK, Zarnegar B, Cheng G. PMID: 17925397.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol. 2007 Jun 01; 178(11):6705-9.
Chang EY, Guo B, Doyle SE, Cheng G. PMID: 17513714.
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PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J Biol Chem. 2007 Apr 20; 282(16):11817-26.
Guo B, Cheng G. PMID: 17327220.
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PubMed Mentions:
101 Fields:
Translation:
HumansAnimalsCells
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Innate immune system regulation of nuclear hormone receptors in metabolic diseases. J Leukoc Biol. 2007 Aug; 82(2):187-95.
Chow EK, Razani B, Cheng G. PMID: 17314330.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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TRAF3 and its biological function. Adv Exp Med Biol. 2007; 597:48-59.
He JQ, Oganesyan G, Saha SK, Zarnegar B, Cheng G. PMID: 17633016.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
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Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. J Biol Chem. 2007 Feb 09; 282(6):3688-94.
He JQ, Saha SK, Kang JR, Zarnegar B, Cheng G. PMID: 17158868.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. J Exp Med. 2006 Nov 27; 203(12):2589-602.
Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. PMID: 17074929; PMCID: PMC2118146.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. J Exp Med. 2006 Oct 30; 203(11):2413-8.
He JQ, Zarnegar B, Oganesyan G, Saha SK, Yamazaki S, Doyle SE, Dempsey PW, Cheng G. PMID: 17015635; PMCID: PMC2118128.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest. 2006 Sep; 116(9):2532-42.
Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA, Standiford TJ. PMID: 16917541; PMCID: PMC1550278.
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PubMed Mentions:
126 Fields:
Translation:
HumansAnimals
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Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 2006 Jul 26; 25(14):3257-63.
Saha SK, Pietras EM, He JQ, Kang JR, Liu SY, Oganesyan G, Shahangian A, Zarnegar B, Shiba TL, Wang Y, Cheng G. PMID: 16858409; PMCID: PMC1523175.
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PubMed Mentions:
196 Fields:
Translation:
HumansAnimalsCells
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TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006 Jul 01; 177(1):298-305.
Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL. PMID: 16785525.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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TRAF3: a new regulator of type I interferons. Cell Cycle. 2006 Apr; 5(8):804-7.
Saha SK, Cheng G. PMID: 16582590.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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The interferon response to bacterial and viral infections. J Endotoxin Res. 2006; 12(4):246-50.
Pietras EM, Saha SK, Cheng G. PMID: 16953977.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity. 2006 Jan; 24(1):79-91.
Miller LS, O'Connell RM, Gutierrez MA, Pietras EM, Shahangian A, Gross CE, Thirumala A, Cheung AL, Cheng G, Modlin RL. PMID: 16413925.
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PubMed Mentions:
191 Fields:
Translation:
AnimalsCells
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TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. EMBO J. 2005 Dec 07; 24(23):4071-81.
Chow EK, O'connell RM, Schilling S, Wang XF, Fu XY, Cheng G. PMID: 16308570; PMCID: PMC1356307.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature. 2006 Jan 12; 439(7073):208-11.
Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B, Perry A, Cheng G. PMID: 16306936.
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PubMed Mentions:
357 Fields:
Translation:
Animals
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[Protective effects of rosiglitazone on hepatotoxicity in hepatocytes cultured with cyclosporine A]. Zhonghua Gan Zang Bing Za Zhi. 2005 Nov; 13(11):855-7.
Liu ZS, Cheng GY, Li HJ, Liu SZ, Yao LN, Li JC. PMID: 16313739.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant. 2005 Aug; 5(8):1793-800.
Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15996225.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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The host type I interferon response to viral and bacterial infections. Cell Res. 2005 Jun; 15(6):407-22.
Perry AK, Chen G, Zheng D, Tang H, Cheng G. PMID: 15987599.
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PubMed Mentions:
172 Fields:
Translation:
HumansAnimalsCells
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Negative regulation of NF-kappaB signaling by PIAS1. Mol Cell Biol. 2005 Feb; 25(3):1113-23.
Liu B, Yang R, Wong KA, Getman C, Stein N, Teitell MA, Cheng G, Wu H, Shuai K. PMID: 15657437; PMCID: PMC544018.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-{kappa}B signaling pathway in non-Hodgkin's lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res. 2005 Jan 01; 65(1):264-76.
Jazirehi AR, Huerta-Yepez S, Cheng G, Bonavida B. PMID: 15665303.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 2004 Dec 15; 173(12):7115-9.
Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15585830.
View in:
PubMed Mentions:
184 Fields:
Translation:
AnimalsCells
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LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004 Oct 15; 119(2):299-309.
Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P. PMID: 15479645.
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PubMed Mentions:
222 Fields:
Translation:
AnimalsCells
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Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med. 2004 Aug 16; 200(4):437-45.
O'Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B, Perry AK, Nguyen BO, Lane TF, Taniguchi T, Miller JF, Cheng G. PMID: 15302901; PMCID: PMC2211937.
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PubMed Mentions:
263 Fields:
Translation:
AnimalsCells
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Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression. Oncogene. 2004 Jun 24; 23(29):4993-5003.
Huerta-Yepez S, Vega M, Jazirehi A, Garban H, Hongo F, Cheng G, Bonavida B. PMID: 15048072.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med. 2004 Jun 21; 199(12):1651-8.
Perry AK, Chow EK, Goodnough JB, Yeh WC, Cheng G. PMID: 15210743; PMCID: PMC2212814.
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PubMed Mentions:
155 Fields:
Translation:
AnimalsCells
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Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8108-13.
Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G. PMID: 15148378; PMCID: PMC419565.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Toll-like receptors induce a phagocytic gene program through p38. J Exp Med. 2004 Jan 05; 199(1):81-90.
Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G. PMID: 14699082; PMCID: PMC1887723.
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PubMed Mentions:
141 Fields:
Translation:
HumansAnimalsCells
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T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). FEBS Lett. 2003 Oct 23; 553(3):403-7.
Dadgostar H, Doyle SE, Shahangian A, Garcia DE, Cheng G. PMID: 14572659.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell. 2003 Oct; 12(4):805-16.
Castrillo A, Joseph SB, Vaidya SA, Haberland M, Fogelman AM, Cheng G, Tontonoz P. PMID: 14580333.
View in:
PubMed Mentions:
181 Fields:
Translation:
AnimalsCells
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NF-kappaB inhibits gammaherpesvirus lytic replication. J Virol. 2003 Aug; 77(15):8532-40.
Brown HJ, Song MJ, Deng H, Wu TT, Cheng G, Sun R. PMID: 12857922; PMCID: PMC165238.
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PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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Toll-like receptors and innate antiviral responses. Curr Opin Immunol. 2003 Aug; 15(4):402-7.
Vaidya SA, Cheng G. PMID: 12900271.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev. 2003 Jun-Aug; 14(3-4):193-209.
Dempsey PW, Doyle SE, He JQ, Cheng G. PMID: 12787559.
View in:
PubMed Mentions:
152 Fields:
Translation:
HumansAnimalsCells
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Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol. 2003 Apr 01; 170(7):3565-71.
Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G. PMID: 12646618.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol. 2003 Apr; 23(7):2543-55.
Ronni T, Agarwal V, Haykinson M, Haberland ME, Cheng G, Smale ST. PMID: 12640135; PMCID: PMC150739.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002 Mar 14; 416(6877):190-4.
Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G. PMID: 11894097.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1497-502.
Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, Rao G, Baltimore D, Cheng G. PMID: 11830667; PMCID: PMC122219.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells