Gerard Chee Lai Wong

Title(s)Professor, Bioengineering
SchoolHenry Samueli School of Engineering and Applied Science
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    Other Positions

    Title(s)Professor, Chemistry and Biochemistry

    Title(s)Professor, CA NanoSystems

    Title(s)Professor, MIMG

    Collapse Research 
    Collapse Research Activities and Funding
    Surface sensing, memory, and motility control in biofilm formation
    NIH R01AI143730Jan 22, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Glyco-therapeutics for Treating Persistent S. aureus Infections of Skin and Soft Tissue
    NIH R21AI122212Jan 1, 2016 - Sep 30, 2018
    Role: Co-Principal Investigator
    Controlling Bacterial Biofilms in Cystic Fibrosis Airways
    NIH R01HL087920Jul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Dissecting Electrostatic Effects in Cystic Fibrosis Muco
    NIH R21DK068431Aug 1, 2004 - Jul 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study. Biochim Biophys Acta Biomembr. 2020 08 01; 1862(8):183302. Lee MW, de Anda J, Kroll C, Bieniossek C, Bradley K, Amrein KE, Wong GCL. PMID: 32311341; PMCID: PMC8720512.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    2. Machine learning antimicrobial peptide sequences: Some surprising variations on the theme of amphiphilic assembly. Curr Opin Colloid Interface Sci. 2018 Nov; 38:204-213. Lee MW, Lee EY, Ferguson AL, Wong GCL. PMID: 31093008; PMCID: PMC6513345.
      View in: PubMed   Mentions: 7  
    3. Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission. ACS Cent Sci. 2017 Nov 22; 3(11):1156-1167. Lee MW, Lee EY, Lai GH, Kennedy NW, Posey AE, Xian W, Ferguson AL, Hill RB, Wong GCL. PMID: 29202017; PMCID: PMC5704292.
      View in: PubMed   Mentions: 14  
    4. High-Speed "4D" Computational Microscopy of Bacterial Surface Motility. ACS Nano. 2017 09 26; 11(9):9340-9351. de Anda J, Lee EY, Lee CK, Bennett RR, Ji X, Soltani S, Harrison MC, Baker AE, Luo Y, Chou T, O'Toole GA, Armani AM, Golestanian R, Wong GCL. PMID: 28836761; PMCID: PMC5978429.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    5. Three-dimensional architecture of Vibrio cholera biofilms. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3711-3. Wong GC. PMID: 27036000; PMCID: PMC4833221.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation. Nat Mater. 2015 Jul; 14(7):696-700. Schmidt NW, Jin F, Lande R, Curk T, Xian W, Lee C, Frasca L, Frenkel D, Dobnikar J, Gilliet M, Wong GC. PMID: 26053762.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    7. Reinventing Cell Penetrating Peptides Using Glycosylated Methionine Sulfonium Ion Sequences. ACS Cent Sci. 2015 May 27; 1(2):83-8. Kramer JR, Schmidt NW, Mayle KM, Kamei DT, Wong GC, Deming TJ. PMID: 27162954; PMCID: PMC4827470.
      View in: PubMed   Mentions: 2  
    8. Pentobra: A Potent Antibiotic with Multiple Layers of Selective Antimicrobial Mechanisms against Propionibacterium Acnes. J Invest Dermatol. 2015 Jun; 135(6):1581-1589. Schmidt NW, Agak GW, Deshayes S, Yu Y, Blacker A, Champer J, Xian W, Kasko AM, Kim J, Wong GCL. PMID: 25668237; PMCID: PMC4430421.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    9. Vibrio cholerae use pili and flagella synergistically to effect motility switching and conditional surface attachment. Nat Commun. 2014 Sep 19; 5:4913. Utada AS, Bennett RR, Fong JCN, Gibiansky ML, Yildiz FH, Golestanian R, Wong GCL. PMID: 25234699; PMCID: PMC4420032.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    10. Engineering persister-specific antibiotics with synergistic antimicrobial functions. ACS Nano. 2014 Sep 23; 8(9):8786-93. Schmidt NW, Deshayes S, Hawker S, Blacker A, Kasko AM, Wong GC. PMID: 25130648; PMCID: PMC4173747.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    11. Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering. Curr Opin Solid State Mater Sci. 2013 Aug; 17(4):151-163. Schmidt NW, Wong GC. PMID: 24778573; PMCID: PMC4000235.
      View in: PubMed   Mentions: 63  
    12. Earthquake-like dynamics in Myxococcus xanthus social motility. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2330-5. Gibiansky ML, Hu W, Dahmen KA, Shi W, Wong GC. PMID: 23341622; PMCID: PMC3568354.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    13. Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. J Biol Chem. 2012 Jun 22; 287(26):21866-72. Schmidt NW, Tai KP, Kamdar K, Mishra A, Lai GH, Zhao K, Ouellette AJ, Wong GC. PMID: 22566697; PMCID: PMC3381149.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Bacteria use type IV pili to walk upright and detach from surfaces. Science. 2010 Oct 08; 330(6001):197. Gibiansky ML, Conrad JC, Jin F, Gordon VD, Motto DA, Mathewson MA, Stopka WG, Zelasko DC, Shrout JD, Wong GC. PMID: 20929769.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
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