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Cole, Gregory M

Title(s)Professor-in-Residence, Neurology
Phone(310) 478-3711x49727
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    Other Positions
    Title(s)Professor-in-Residence, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    CTBI: Tauopathy in mice and human: Surrogate Plasma Biomarkers for Brain Trauma-Initiated Neurodegenerative Disease
    VA I01BX004332Oct 1, 2019 - Sep 30, 2023
    Role: Principal Investigator
    Treating Alzheimer's disease by reducing brain insulin resistance with incretin receptor agonists
    NIH/NIA R01AG057658May 15, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    How to modulate innate immune function to prevent age-related neurodegeneration
    VA I01BX002476Jan 1, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
    NIH/NCCIH R01AT006816Sep 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Mechanisms for NSAID Alzheimer Prevention
    VA I01BX000542Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Diet and Exercise (DE) Program for Alzheimer Prevention
    NIH/NIA RC1AG035878Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Can Omega 3 fatty acids Slow Alzheimer Pathogenesis?
    NIH/NCCIH R01AT003008Sep 1, 2005 - Aug 31, 2010
    Role: Principal Investigator
    AMEYLOID VACCINE, AMYLOID REMOVAL MECHANISMS AND SYNAPTI
    NIH/NINDS R01NS043946Sep 30, 2001 - Aug 31, 2007
    Role: Principal Investigator
    NSAID Inhibition of Alzheimer Pathology: Role of DHA
    NIH/NIA R01AG013741Jan 1, 1998 - Dec 31, 2000
    Role: Principal Investigator
    A NEW APPROACH TO ALZHEIMER PROTEIN BIOCHEMISTRY
    NIH/NIA R01AG011125Jun 15, 1993 - Nov 30, 1993
    Role: Principal Investigator
    AMYLOID PRECURSOR IN ALZHEIMER'S DISEASE BRAIN
    NIH/NIA R01AG009009May 2, 1990 - Nov 30, 1993
    Role: Principal Investigator
    IN VITRO MODEL FOR ALZHEIMER MOLECULAR PATHOLOGY
    NIH/NIA F32AG005424Mar 30, 1988
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yoon AJ, Wu H, Pan RD, Teter B, Cipolla J, Chang E, Avila LZ, Basak SK, Srivatsan ES, Wang MB, Cole GM, Frautschy SA, Hampton PD, Faull KF. A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples. Anal Biochem. 2020 May 01; 596:113636. PMID: 32081619.
      View in: PubMed
    2. Denver P, D'Adamo H, Hu S, Zuo X, Zhu C, Okuma C, Kim P, Castro D, Jones MR, Leal C, Mekkittikul M, Ghadishah E, Teter B, Vinters HV, Cole GM, Frautschy SA. A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. Front Physiol. 2019; 10:1269. PMID: 31708792.
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    3. Teter B, Morihara T, Lim GP, Chu T, Jones MR, Zuo X, Paul RM, Frautschy SA, Cole GM. Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis. Neurobiol Dis. 2019 07; 127:432-448. PMID: 30951849.
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    4. Ma QL, Teng E, Zuo X, Jones M, Teter B, Zhao EY, Zhu C, Bilousova T, Gylys KH, Apostolova LG, LaDu MJ, Hossain MA, Frautschy SA, Cole GM. Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease. Neurobiol Dis. 2018 06; 114:120-128. PMID: 29501530.
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    5. Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease. JCI Insight. 2017 Aug 17; 2(16). PMID: 28814675.
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    6. Teter B, LaDu MJ, Sullivan PM, Frautschy SA, Cole GM. Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. Neuroreport. 2016 08 03; 27(11):791-5. PMID: 27281274.
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    7. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. Synaptic Amyloid-ß Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 2016 Jan; 186(1):185-98. PMID: 26718979.
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    8. Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe CG, Takacs A, Hoffman DR, Frautschy SA, Cole GM. Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aß pathology and modulates Aß oligomerization. Neurobiol Dis. 2015 Oct; 82:552-560. PMID: 26369878.
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    9. Chan ES, Chen C, Cole GM, Wong BS. Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Sci Rep. 2015 Sep 08; 5:13842. PMID: 26346625.
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    10. Hwang KS, Lazaris AS, Eastman JA, Teng E, Thompson PM, Gylys KH, Cole GM, Apostolova LG. Plasma BDNF levels associate with Pittsburgh compound B binding in the brain. Alzheimers Dement (Amst). 2015 Jun 01; 1(2):187-193. PMID: 26207261.
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    11. Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dement Geriatr Cogn Disord. 2015; 39(3-4):154-66. PMID: 25547651.
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    12. Bilousova T, Taylor K, Emirzian A, Gylys R, Frautschy SA, Cole GM, Teng E. Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. Neurobiol Dis. 2015 Feb; 74:32-40. PMID: 25449907.
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    13. Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Kiosea NC, Nazari S, Chen PP, Nothias F, Chan P, Teng E, Frautschy SA, Cole GM. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci. 2014 May 21; 34(21):7124-36. PMID: 24849348.
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    14. Ong QR, Chan ES, Lim ML, Cole GM, Wong BS. Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice. Sci Rep. 2014 Jan 17; 4:3754. PMID: 24435134.
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    15. Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Teng E, Hu S, Chen PP, Maiti P, Teter B, Cole GM, Frautschy SA. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem. 2013 Feb 08; 288(6):4056-65. PMID: 23264626.
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    16. Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek GB, Teplow DB. C-terminal turn stability determines assembly differences between Aß40 and Aß42. J Mol Biol. 2013 Jan 23; 425(2):292-308. PMID: 23154165.
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    17. Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012; 4(5):43. PMID: 23107780.
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    18. Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL, Cole GM. Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype. Arch Neurol. 2012 Jun; 69(6):757-64. PMID: 22689192.
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    19. Ma QL, Yang F, Frautschy SA, Cole GM. PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist. 2012 Apr 01; 2(2):117-125. PMID: 23162743.
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    20. Ringman JM, Coppola G, Elashoff D, Rodriguez-Agudelo Y, Medina LD, Gylys K, Cummings JL, Cole GM. Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2012; 33(1):1-5. PMID: 22343824.
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    21. Sokolow S, Henkins KM, Williams IA, Vinters HV, Schmid I, Cole GM, Gylys KH. Isolation of synaptic terminals from Alzheimer's disease cortex. Cytometry A. 2012 Mar; 81(3):248-54. PMID: 22213704.
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    22. Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathol. 2012 Jan; 123(1):39-52. PMID: 22020632.
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    23. Sokolow S, Henkins KM, Bilousova T, Miller CA, Vinters HV, Poon W, Cole GM, Gylys KH. AD synapses contain abundant Aß monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging. 2012 Aug; 33(8):1545-55. PMID: 21741125.
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    24. Teng E, Kepe V, Frautschy SA, Liu J, Satyamurthy N, Yang F, Chen PP, Cole GB, Jones MR, Huang SC, Flood DG, Trusko SP, Small GW, Cole GM, Barrio JR. [F-18]FDDNP microPET imaging correlates with brain Aß burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aß antibody treatment. Neurobiol Dis. 2011 Sep; 43(3):565-75. PMID: 21605674.
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    25. Frautschy SA, Cole GM. What was lost in translation in the DHA trial is whom you should intend to treat. Alzheimers Res Ther. 2011 Jan 20; 3(1):2. PMID: 21251328.
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    26. Cole GM, Ma QL, Frautschy SA. Dietary fatty acids and the aging brain. Nutr Rev. 2010 Dec; 68 Suppl 2:S102-11. PMID: 21091943.
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    27. Frautschy SA, Cole GM. Why pleiotropic interventions are needed for Alzheimer's disease. Mol Neurobiol. 2010 Jun; 41(2-3):392-409. PMID: 20437209.
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    28. Cole GM, Frautschy SA. DHA may prevent age-related dementia. J Nutr. 2010 Apr; 140(4):869-74. PMID: 20181786.
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    29. Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 2009 Jul 15; 29(28):9078-89. PMID: 19605645.
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    30. Cole GM, Ma QL, Frautschy SA. Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep; 81(2-3):213-21. PMID: 19523795.
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    31. Ercoli LM, Siddarth P, Kepe V, Miller KJ, Huang SC, Cole GM, Lavretsky H, Bookheimer SY, Kim J, Phelps ME, Barrio JR, Small GW. Differential FDDNP PET patterns in nondemented middle-aged and older adults. Am J Geriatr Psychiatry. 2009 May; 17(5):397-406. PMID: 19390297.
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    32. Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland SD, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr; 66(4):448-57. PMID: 19364929.
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    33. Small GW, Siddarth P, Burggren AC, Kepe V, Ercoli LM, Miller KJ, Lavretsky H, Thompson PM, Cole GM, Huang SC, Phelps ME, Bookheimer SY, Barrio JR. Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Arch Gen Psychiatry. 2009 Jan; 66(1):81-7. PMID: 19124691.
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    34. Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. J Alzheimers Dis. 2008 Dec; 15(4):625-40. PMID: 19096161.
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    35. Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 2008 Jul 08; 71(2):85-92. PMID: 18509095.
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    36. Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol. 2008 Jun; 172(6):1683-92. PMID: 18467692.
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    37. Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther. 2008 Jul; 326(1):196-208. PMID: 18417733.
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    38. Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol Chem. 2008 May 16; 283(20):14132-43. PMID: 18347024.
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    39. Small GW, Bookheimer SY, Thompson PM, Cole GM, Huang SC, Kepe V, Barrio JR. Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol. 2008 Feb; 7(2):161-72. PMID: 18207114.
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    40. Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM. Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J Neurosci. 2007 Dec 26; 27(52):14299-307. PMID: 18160637.
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    41. Ma QL, Harris-White ME, Ubeda OJ, Simmons M, Beech W, Lim GP, Teter B, Frautschy SA, Cole GM. Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. J Neurochem. 2007 Nov; 103(4):1594-607. PMID: 17760871.
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    42. Cole GM, Teter B, Frautschy SA. Neuroprotective effects of curcumin. Adv Exp Med Biol. 2007; 595:197-212. PMID: 17569212.
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    43. Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006 Dec 21; 355(25):2652-63. PMID: 17182990.
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    44. Cole GM, Frautschy SA. The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease. Exp Gerontol. 2007 Jan-Feb; 42(1-2):10-21. PMID: 17049785.
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    45. Cole GM, Frautschy SA. Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." Pleiotropic approaches to Alzheimer's and other diseases of aging. Alzheimers Dement. 2006 Oct; 2(4):284-6. PMID: 19595901.
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    46. Cole GM, Frautschy SA. Alzheimer's amyloid story finds its star. Trends Mol Med. 2006 Sep; 12(9):395-6. PMID: 16880006.
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    47. Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15; 83(3):374-84. PMID: 16385556.
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    48. Kepe V, Barrio JR, Huang SC, Ercoli L, Siddarth P, Shoghi-Jadid K, Cole GM, Satyamurthy N, Cummings JL, Small GW, Phelps ME. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):702-7. PMID: 16407119.
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    49. Cole GM, Frautschy SA. Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. Nutr Health. 2006; 18(3):249-59. PMID: 17180870.
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    50. Gylys KH, Fein JA, Yang F, Miller CA, Cole GM. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging. 2007 Jan; 28(1):8-17. PMID: 16332401.
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    51. Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA. Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Dec; 26 Suppl 1:133-6. PMID: 16266772.
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    52. Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N, Frautschy SA, Cole GM. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci. 2005 Aug; 22(3):617-26. PMID: 16101743.
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    53. Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):131-6. PMID: 15974909.
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    54. Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N, Frautschy SA, Cole GM. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005 Mar 23; 25(12):3032-40. PMID: 15788759.
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    55. Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci. 2004 Dec 08; 24(49):11120-6. PMID: 15590928.
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    56. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18; 280(7):5892-901. PMID: 15590663.
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    57. Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. Int J Oncol. 2004 Dec; 25(6):1867-73. PMID: 15547728.
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    58. Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N Y Acad Sci. 2004 Dec; 1035:68-84. PMID: 15681801.
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    59. Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM. Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol. 2004 Nov; 165(5):1809-17. PMID: 15509549.
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    60. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N, Ashe KH, Frautschy SA, Cole GM. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron. 2004 Sep 02; 43(5):633-45. PMID: 15339646.
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    61. Gylys KH, Fein JA, Yang F, Cole GM. Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex. Cytometry A. 2004 Jul; 60(1):90-6. PMID: 15229861.
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    62. D'Andrea MR, Cole GM, Ard MD. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging. 2004 May-Jun; 25(5):675-83. PMID: 15172747.
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    63. Gylys KH, Fein JA, Wiley DJ, Cole GM. Rapid annexin-V labeling in synaptosomes. Neurochem Int. 2004 Feb; 44(3):125-31. PMID: 14568554.
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    64. Cole GM. Ironic fate: can a banned drug control metal heavies in neurodegenerative diseases? Neuron. 2003 Mar 27; 37(6):889-90. PMID: 12670416.
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    65. Weisbart RH, Yang F, Chan G, Wakelin R, Ferreri K, Zack DJ, Harrison B, Leinwand LA, Cole GM. Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb. Mol Immunol. 2003 Mar; 39(13):783-9. PMID: 12617993.
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    66. Gylys KH, Fein JA, Tan AM, Cole GM. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals. J Neurochem. 2003 Mar; 84(6):1442-51. PMID: 12614344.
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    67. Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile. Neuroscience. 2003; 117(3):723-30. PMID: 12617976.
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    68. Morihara T, Chu T, Ubeda O, Beech W, Cole GM. Selective inhibition of Abeta42 production by NSAID R-enantiomers. J Neurochem. 2002 Nov; 83(4):1009-12. PMID: 12421374.
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    69. Gylys KH, Fein JA, Cole GM. Caspase inhibition protects nerve terminals from in vitro degradation. Neurochem Res. 2002 Jun; 27(6):465-72. PMID: 12199150.
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    70. Teter B, Xu PT, Gilbert JR, Roses AD, Galasko D, Cole GM. Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. J Neurosci Res. 2002 May 01; 68(3):331-6. PMID: 12111863.
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    71. Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy SA, Takashima A. Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging. 2002 Mar-Apr; 23(2):195-203. PMID: 11804703.
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    72. Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci. 2001 Dec 15; 21(24):RC189. PMID: 11734604.
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    73. Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001 Nov-Dec; 22(6):993-1005. PMID: 11755008.
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    74. Harris-White ME, Chu T, Miller SA, Simmons M, Teter B, Nash D, Cole GM, Frautschy SA. Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo. Neurochem Int. 2001 Nov-Dec; 39(5-6):435-48. PMID: 11578779.
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    75. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 01; 21(21):8370-7. PMID: 11606625.
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    76. Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 2001 Nov-Dec; 22(6):983-91. PMID: 11755007.
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    77. Cole GM, Frautschy SA. Church baptizes Joseph and Perry. Eccentric views absolved. Neurobiol Aging. 2001 Jan-Feb; 22(1):147-50; discussion 161-3. PMID: 11164288.
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    78. Cole GM, Ard MD. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microsc Res Tech. 2000 Aug 15; 50(4):316-24. PMID: 10936886.
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    79. Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. 2000 Aug 01; 20(15):5709-14. PMID: 10908610.
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    80. Gylys KH, Fein JA, Cole GM. Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry. J Neurosci Res. 2000 Jul 15; 61(2):186-92. PMID: 10878591.
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    81. Yang F, Uéda K, Chen P, Ashe KH, Cole GM. Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. Brain Res. 2000 Jan 24; 853(2):381-3. PMID: 10640638.
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    82. Cole GM, Beech W, Frautschy SA, Sigel J, Glasgow C, Ard MD. Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro. J Neurosci Res. 1999 Aug 15; 57(4):504-20. PMID: 10440900.
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    83. Teter B, Harris-White ME, Frautschy SA, Cole GM. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience. 1999; 91(3):1009-16. PMID: 10391478.
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    84. Pulera MR, Adams LM, Liu H, Santos DG, Nishimura RN, Yang F, Cole GM, Wasterlain CG. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke. 1998 Dec; 29(12):2622-30. PMID: 9836776.
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    85. Chu T, Tran T, Yang F, Beech W, Cole GM, Frautschy SA. Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line. FEBS Lett. 1998 Oct 09; 436(3):439-44. PMID: 9801165.
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    86. Cummings JL, Vinters HV, Cole GM, Khachaturian ZS. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology. 1998 Jul; 51(1 Suppl 1):S2-17; discussion S65-7. PMID: 9674758.
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    87. Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998 Feb; 152(2):379-89. PMID: 9466564.
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    88. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. 1998 Jan; 152(1):307-17. PMID: 9422548.
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    89. Frautschy SA, Yang F, Calderón L, Cole GM. Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging. 1996 Mar-Apr; 17(2):311-21. PMID: 8744413.
      View in: PubMed
    90. Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM. Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res. 1994 Dec 19; 667(1):138-42. PMID: 7895077.
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    91. Yang F, Mak K, Vinters HV, Frautschy SA, Cole GM. Monoclonal antibody to the C-terminus of beta-amyloid. Neuroreport. 1994 Oct 27; 5(16):2117-20. PMID: 7865758.
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