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Gregory M Cole

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
Address555 Westwood Plaza MAILROOM
Los Angeles CA 90024
Phone(310) 478-3711x49727
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    Collapse Research 
    Collapse Research Activities and Funding
    CTBI: Tauopathy in mice and human: Surrogate Plasma Biomarkers for Brain Trauma-Initiated Neurodegenerative Disease
    VA I01BX004332Oct 1, 2019 - Sep 30, 2023
    Role: Principal Investigator
    Treating Alzheimer's disease by reducing brain insulin resistance with incretin receptor agonists
    NIH/NIA R01AG057658May 15, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    How to modulate innate immune function to prevent age-related neurodegeneration
    VA I01BX002476Jan 1, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
    NIH/NCCIH R01AT006816Sep 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Mechanisms for NSAID Alzheimer Prevention
    VA I01BX000542Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Diet and Exercise (DE) Program for Alzheimer Prevention
    NIH/NIA RC1AG035878Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Can Omega 3 fatty acids Slow Alzheimer Pathogenesis?
    NIH/NCCIH R01AT003008Sep 1, 2005 - Aug 31, 2010
    Role: Principal Investigator
    AMEYLOID VACCINE, AMYLOID REMOVAL MECHANISMS AND SYNAPTI
    NIH/NINDS R01NS043946Sep 30, 2001 - Aug 31, 2007
    Role: Principal Investigator
    NSAID Inhibition of Alzheimer Pathology: Role of DHA
    NIH/NIA R01AG013741Jan 1, 1998 - Dec 31, 2000
    Role: Principal Investigator
    A NEW APPROACH TO ALZHEIMER PROTEIN BIOCHEMISTRY
    NIH/NIA R01AG011125Jun 15, 1993 - Nov 30, 1993
    Role: Principal Investigator
    AMYLOID PRECURSOR IN ALZHEIMER'S DISEASE BRAIN
    NIH/NIA R01AG009009May 2, 1990 - Nov 30, 1993
    Role: Principal Investigator
    IN VITRO MODEL FOR ALZHEIMER MOLECULAR PATHOLOGY
    NIH/NIA F32AG005424Mar 30, 1988
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples. Anal Biochem. 2020 05 01; 596:113636. Yoon AJ, Wu H, Pan RD, Teter B, Cipolla J, Chang E, Avila LZ, Basak SK, Srivatsan ES, Wang MB, Cole GM, Frautschy SA, Hampton PD, Faull KF. PMID: 32081619.
      View in: PubMed   Mentions:    Fields:    
    2. A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. Front Physiol. 2019; 10:1269. Denver P, D'Adamo H, Hu S, Zuo X, Zhu C, Okuma C, Kim P, Castro D, Jones MR, Leal C, Mekkittikul M, Ghadishah E, Teter B, Vinters HV, Cole GM, Frautschy SA. PMID: 31708792.
      View in: PubMed   Mentions:
    3. Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis. Neurobiol Dis. 2019 07; 127:432-448. Teter B, Morihara T, Lim GP, Chu T, Jones MR, Zuo X, Paul RM, Frautschy SA, Cole GM. PMID: 30951849.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease. Neurobiol Dis. 2018 06; 114:120-128. Ma QL, Teng E, Zuo X, Jones M, Teter B, Zhao EY, Zhu C, Bilousova T, Gylys KH, Apostolova LG, LaDu MJ, Hossain MA, Frautschy SA, Cole GM. PMID: 29501530.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease. JCI Insight. 2017 Aug 17; 2(16). Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M. PMID: 28814675.
      View in: PubMed   Mentions: 42     Fields:    
    6. Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. Neuroreport. 2016 08 03; 27(11):791-5. Teter B, LaDu MJ, Sullivan PM, Frautschy SA, Cole GM. PMID: 27281274.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Synaptic Amyloid-ß Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 2016 Jan; 186(1):185-98. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. PMID: 26718979.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    8. Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aß pathology and modulates Aß oligomerization. Neurobiol Dis. 2015 Oct; 82:552-560. Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe CG, Takacs A, Hoffman DR, Frautschy SA, Cole GM. PMID: 26369878.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Sci Rep. 2015 Sep 08; 5:13842. Chan ES, Chen C, Cole GM, Wong BS. PMID: 26346625.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. Plasma BDNF levels associate with Pittsburgh compound B binding in the brain. Alzheimers Dement (Amst). 2015 Jun 01; 1(2):187-193. Hwang KS, Lazaris AS, Eastman JA, Teng E, Thompson PM, Gylys KH, Cole GM, Apostolova LG. PMID: 26207261.
      View in: PubMed   Mentions:
    11. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dement Geriatr Cogn Disord. 2015; 39(3-4):154-66. Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG. PMID: 25547651.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. Neurobiol Dis. 2015 Feb; 74:32-40. Bilousova T, Taylor K, Emirzian A, Gylys R, Frautschy SA, Cole GM, Teng E. PMID: 25449907.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci. 2014 May 21; 34(21):7124-36. Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Kiosea NC, Nazari S, Chen PP, Nothias F, Chan P, Teng E, Frautschy SA, Cole GM. PMID: 24849348.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    14. Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice. Sci Rep. 2014 Jan 17; 4:3754. Ong QR, Chan ES, Lim ML, Cole GM, Wong BS. PMID: 24435134.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    15. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem. 2013 Feb 08; 288(6):4056-65. Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Teng E, Hu S, Chen PP, Maiti P, Teter B, Cole GM, Frautschy SA. PMID: 23264626.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    16. C-terminal turn stability determines assembly differences between Aß40 and Aß42. J Mol Biol. 2013 Jan 23; 425(2):292-308. Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek GB, Teplow DB. PMID: 23154165.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    17. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012; 4(5):43. Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. PMID: 23107780.
      View in: PubMed   Mentions: 58     Fields:    
    18. Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype. Arch Neurol. 2012 Jun; 69(6):757-64. Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL, Cole GM. PMID: 22689192.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    19. PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist. 2012 Apr 01; 2(2):117-125. Ma QL, Yang F, Frautschy SA, Cole GM. PMID: 23162743.
      View in: PubMed   Mentions:
    20. Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2012; 33(1):1-5. Ringman JM, Coppola G, Elashoff D, Rodriguez-Agudelo Y, Medina LD, Gylys K, Cummings JL, Cole GM. PMID: 22343824.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. Isolation of synaptic terminals from Alzheimer's disease cortex. Cytometry A. 2012 Mar; 81(3):248-54. Sokolow S, Henkins KM, Williams IA, Vinters HV, Schmid I, Cole GM, Gylys KH. PMID: 22213704.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathol. 2012 Jan; 123(1):39-52. Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH. PMID: 22020632.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    23. AD synapses contain abundant Aß monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging. 2012 Aug; 33(8):1545-55. Sokolow S, Henkins KM, Bilousova T, Miller CA, Vinters HV, Poon W, Cole GM, Gylys KH. PMID: 21741125.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    24. [F-18]FDDNP microPET imaging correlates with brain Aß burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aß antibody treatment. Neurobiol Dis. 2011 Sep; 43(3):565-75. Teng E, Kepe V, Frautschy SA, Liu J, Satyamurthy N, Yang F, Chen PP, Cole GB, Jones MR, Huang SC, Flood DG, Trusko SP, Small GW, Cole GM, Barrio JR. PMID: 21605674.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. What was lost in translation in the DHA trial is whom you should intend to treat. Alzheimers Res Ther. 2011 Jan 20; 3(1):2. Frautschy SA, Cole GM. PMID: 21251328.
      View in: PubMed   Mentions: 5     Fields:    
    26. Dietary fatty acids and the aging brain. Nutr Rev. 2010 Dec; 68 Suppl 2:S102-11. Cole GM, Ma QL, Frautschy SA. PMID: 21091943.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    27. Why pleiotropic interventions are needed for Alzheimer's disease. Mol Neurobiol. 2010 Jun; 41(2-3):392-409. Frautschy SA, Cole GM. PMID: 20437209.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    28. DHA may prevent age-related dementia. J Nutr. 2010 Apr; 140(4):869-74. Cole GM, Frautschy SA. PMID: 20181786.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    29. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 2009 Jul 15; 29(28):9078-89. Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM. PMID: 19605645.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    30. Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep; 81(2-3):213-21. Cole GM, Ma QL, Frautschy SA. PMID: 19523795.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    31. Differential FDDNP PET patterns in nondemented middle-aged and older adults. Am J Geriatr Psychiatry. 2009 May; 17(5):397-406. Ercoli LM, Siddarth P, Kepe V, Miller KJ, Huang SC, Cole GM, Lavretsky H, Bookheimer SY, Kim J, Phelps ME, Barrio JR, Small GW. PMID: 19390297.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    32. Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr; 66(4):448-57. Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland SD, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. PMID: 19364929.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    33. Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Arch Gen Psychiatry. 2009 Jan; 66(1):81-7. Small GW, Siddarth P, Burggren AC, Kepe V, Ercoli LM, Miller KJ, Lavretsky H, Thompson PM, Cole GM, Huang SC, Phelps ME, Bookheimer SY, Barrio JR. PMID: 19124691.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    34. Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. J Alzheimers Dis. 2008 Dec; 15(4):625-40. Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. PMID: 19096161.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    35. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 2008 Jul 08; 71(2):85-92. Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. PMID: 18509095.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    36. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol. 2008 Jun; 172(6):1683-92. Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH. PMID: 18467692.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    37. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther. 2008 Jul; 326(1):196-208. Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. PMID: 18417733.
      View in: PubMed   Mentions: 131     Fields:    Translation:Animals
    38. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol Chem. 2008 May 16; 283(20):14132-43. Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. PMID: 18347024.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    39. Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol. 2008 Feb; 7(2):161-72. Small GW, Bookheimer SY, Thompson PM, Cole GM, Huang SC, Kepe V, Barrio JR. PMID: 18207114.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    40. Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J Neurosci. 2007 Dec 26; 27(52):14299-307. Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM. PMID: 18160637.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    41. Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. J Neurochem. 2007 Nov; 103(4):1594-607. Ma QL, Harris-White ME, Ubeda OJ, Simmons M, Beech W, Lim GP, Teter B, Frautschy SA, Cole GM. PMID: 17760871.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    42. Neuroprotective effects of curcumin. Adv Exp Med Biol. 2007; 595:197-212. Cole GM, Teter B, Frautschy SA. PMID: 17569212.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    43. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006 Dec 21; 355(25):2652-63. Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR. PMID: 17182990.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansCells
    44. The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease. Exp Gerontol. 2007 Jan-Feb; 42(1-2):10-21. Cole GM, Frautschy SA. PMID: 17049785.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    45. Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." Pleiotropic approaches to Alzheimer's and other diseases of aging. Alzheimers Dement. 2006 Oct; 2(4):284-6. Cole GM, Frautschy SA. PMID: 19595901.
      View in: PubMed   Mentions: 1     Fields:    
    46. Alzheimer's amyloid story finds its star. Trends Mol Med. 2006 Sep; 12(9):395-6. Cole GM, Frautschy SA. PMID: 16880006.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    47. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15; 83(3):374-84. Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. PMID: 16385556.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    48. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):702-7. Kepe V, Barrio JR, Huang SC, Ercoli L, Siddarth P, Shoghi-Jadid K, Cole GM, Satyamurthy N, Cummings JL, Small GW, Phelps ME. PMID: 16407119.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    49. Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. Nutr Health. 2006; 18(3):249-59. Cole GM, Frautschy SA. PMID: 17180870.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    50. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging. 2007 Jan; 28(1):8-17. Gylys KH, Fein JA, Yang F, Miller CA, Cole GM. PMID: 16332401.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    51. Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Dec; 26 Suppl 1:133-6. Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA. PMID: 16266772.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    52. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci. 2005 Aug; 22(3):617-26. Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N, Frautschy SA, Cole GM. PMID: 16101743.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    53. A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):131-6. Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. PMID: 15974909.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    54. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005 Mar 23; 25(12):3032-40. Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N, Frautschy SA, Cole GM. PMID: 15788759.
      View in: PubMed   Mentions: 151     Fields:    Translation:Animals
    55. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci. 2004 Dec 08; 24(49):11120-6. Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM. PMID: 15590928.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    56. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18; 280(7):5892-901. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. PMID: 15590663.
      View in: PubMed   Mentions: 408     Fields:    Translation:HumansAnimalsCells
    57. Antibody-mediated transduction of p53 selectively kills cancer cells. Int J Oncol. 2004 Dec; 25(6):1867-73. Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. PMID: 15547728.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N Y Acad Sci. 2004 Dec; 1035:68-84. Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. PMID: 15681801.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    59. Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol. 2004 Nov; 165(5):1809-17. Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM. PMID: 15509549.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    60. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron. 2004 Sep 02; 43(5):633-45. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N, Ashe KH, Frautschy SA, Cole GM. PMID: 15339646.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    61. Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex. Cytometry A. 2004 Jul; 60(1):90-6. Gylys KH, Fein JA, Yang F, Cole GM. PMID: 15229861.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    62. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging. 2004 May-Jun; 25(5):675-83. D'Andrea MR, Cole GM, Ard MD. PMID: 15172747.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    63. Rapid annexin-V labeling in synaptosomes. Neurochem Int. 2004 Feb; 44(3):125-31. Gylys KH, Fein JA, Wiley DJ, Cole GM. PMID: 14568554.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    64. Ironic fate: can a banned drug control metal heavies in neurodegenerative diseases? Neuron. 2003 Mar 27; 37(6):889-90. Cole GM. PMID: 12670416.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    65. Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb. Mol Immunol. 2003 Mar; 39(13):783-9. Weisbart RH, Yang F, Chan G, Wakelin R, Ferreri K, Zack DJ, Harrison B, Leinwand LA, Cole GM. PMID: 12617993.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    66. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals. J Neurochem. 2003 Mar; 84(6):1442-51. Gylys KH, Fein JA, Tan AM, Cole GM. PMID: 12614344.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    67. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile. Neuroscience. 2003; 117(3):723-30. Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR. PMID: 12617976.
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    68. Selective inhibition of Abeta42 production by NSAID R-enantiomers. J Neurochem. 2002 Nov; 83(4):1009-12. Morihara T, Chu T, Ubeda O, Beech W, Cole GM. PMID: 12421374.
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    69. Caspase inhibition protects nerve terminals from in vitro degradation. Neurochem Res. 2002 Jun; 27(6):465-72. Gylys KH, Fein JA, Cole GM. PMID: 12199150.
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    70. Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. J Neurosci Res. 2002 May 01; 68(3):331-6. Teter B, Xu PT, Gilbert JR, Roses AD, Galasko D, Cole GM. PMID: 12111863.
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    71. Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging. 2002 Mar-Apr; 23(2):195-203. Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy SA, Takashima A. PMID: 11804703.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    72. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci. 2001 Dec 15; 21(24):RC189. Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR. PMID: 11734604.
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    73. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001 Nov-Dec; 22(6):993-1005. Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM. PMID: 11755008.
      View in: PubMed   Mentions: 109     Fields:    Translation:Cells
    74. Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo. Neurochem Int. 2001 Nov-Dec; 39(5-6):435-48. Harris-White ME, Chu T, Miller SA, Simmons M, Teter B, Nash D, Cole GM, Frautschy SA. PMID: 11578779.
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    75. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 01; 21(21):8370-7. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. PMID: 11606625.
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    76. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 2001 Nov-Dec; 22(6):983-91. Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. PMID: 11755007.
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    77. Church baptizes Joseph and Perry. Eccentric views absolved. Neurobiol Aging. 2001 Jan-Feb; 22(1):147-50; discussion 161-3. Cole GM, Frautschy SA. PMID: 11164288.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    78. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microsc Res Tech. 2000 Aug 15; 50(4):316-24. Cole GM, Ard MD. PMID: 10936886.
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    79. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. 2000 Aug 01; 20(15):5709-14. Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM. PMID: 10908610.
      View in: PubMed   Mentions: 222     Fields:    Translation:AnimalsCells
    80. Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry. J Neurosci Res. 2000 Jul 15; 61(2):186-92. Gylys KH, Fein JA, Cole GM. PMID: 10878591.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    81. Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. Brain Res. 2000 Jan 24; 853(2):381-3. Yang F, Uéda K, Chen P, Ashe KH, Cole GM. PMID: 10640638.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    82. Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro. J Neurosci Res. 1999 Aug 15; 57(4):504-20. Cole GM, Beech W, Frautschy SA, Sigel J, Glasgow C, Ard MD. PMID: 10440900.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    83. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience. 1999; 91(3):1009-16. Teter B, Harris-White ME, Frautschy SA, Cole GM. PMID: 10391478.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    84. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke. 1998 Dec; 29(12):2622-30. Pulera MR, Adams LM, Liu H, Santos DG, Nishimura RN, Yang F, Cole GM, Wasterlain CG. PMID: 9836776.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    85. Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line. FEBS Lett. 1998 Oct 09; 436(3):439-44. Chu T, Tran T, Yang F, Beech W, Cole GM, Frautschy SA. PMID: 9801165.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    86. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology. 1998 Jul; 51(1 Suppl 1):S2-17; discussion S65-7. Cummings JL, Vinters HV, Cole GM, Khachaturian ZS. PMID: 9674758.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    87. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998 Feb; 152(2):379-89. Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM. PMID: 9466564.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    88. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. 1998 Jan; 152(1):307-17. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. PMID: 9422548.
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    89. Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging. 1996 Mar-Apr; 17(2):311-21. Frautschy SA, Yang F, Calderón L, Cole GM. PMID: 8744413.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    90. Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res. 1994 Dec 19; 667(1):138-42. Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM. PMID: 7895077.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    91. Monoclonal antibody to the C-terminus of beta-amyloid. Neuroreport. 1994 Oct 27; 5(16):2117-20. Yang F, Mak K, Vinters HV, Frautschy SA, Cole GM. PMID: 7865758.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
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