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Eibl, Guido

Title(s)Professor-in-Residence, Surgery
SchoolGeneral Surgery
Phone49577
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinoma
    NIH/NCI P01CA163200Aug 1, 2012 - Jul 31, 2017
    Role: Principal Investigator
    The role of n-3 polyunsaturated fatty acids in pancreatic cancer
    NIH/NCI R01CA122042Aug 1, 2007 - May 31, 2013
    Role: Principal Investigator
    The Role of COX-2 and PPAR-Gamma in Pancreatic Cancer
    NIH/NCI R01CA104027Mar 1, 2004 - Feb 29, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka W, Rozengurt E, Jacobs JP, Eibl G. Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2019 Dec 01; 317(6):G763-G772. PMID: 31545922.
      View in: PubMed
    2. Chang HH, Eibl G. Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma. Cells. 2019 07 03; 8(7). PMID: 31277269.
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    3. Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC. Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer. Pancreas. 2019 07; 48(6):759-779. PMID: 31206467.
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    4. Hao F, Xu Q, Wang J, Yu S, Chang HH, Sinnett-Smith J, Eibl G, Rozengurt E. Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. PLoS One. 2019; 14(5):e0216603. PMID: 31100067.
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    5. Rozengurt E, Eibl G. Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. World J Gastroenterol. 2019 Apr 21; 25(15):1797-1816. PMID: 31057295.
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    6. Massoumi RL, Hines OJ, Eibl G, King JC. Emerging Evidence for the Clinical Relevance of Pancreatic Cancer Exosomes. Pancreas. 2019 01; 48(1):1-8. PMID: 30531240.
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    7. Juo YY, Gibbons MAM, Dutson E, Lin AY, Yanagawa J, Hines OJ, Eibl G, Chen Y. Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California. J Obes. 2018; 2018:7014073. PMID: 30327727.
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    8. Xu M, Chang HH, Jung X, Moro A, Chou CEN, King J, Hines OJ, Sinnett-Smith J, Rozengurt E, Eibl G. Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice. BMC Cancer. 2018 Aug 07; 18(1):797. PMID: 30086728.
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    9. Kaur K, Chang HH, Topchyan P, Cook JM, Barkhordarian A, Eibl G, Jewett A. Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice. Front Immunol. 2018; 9:1229. PMID: 29977235.
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    10. Chen Y, Dutson E, Eibl G. Strategies to Prevent Obesity-Related Cancer. JAMA. 2018 06 19; 319(23):2442. PMID: 29922821.
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    11. Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC. The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2018 May/Jun; 47(5):516-525. PMID: 29702529.
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    12. Rozengurt E, Sinnett-Smith J, Eibl G. Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. Signal Transduct Target Ther. 2018; 3:11. PMID: 29682330.
      View in: PubMed
    13. Chang HH, Moro A, Chou CEN, Dawson DW, French S, Schmidt AI, Sinnett-Smith J, Hao F, Hines OJ, Eibl G, Rozengurt E. Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. Sci Rep. 2018 04 12; 8(1):5899. PMID: 29651002.
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    14. Xu M, Jung X, Hines OJ, Eibl G, Chen Y. Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss. Pancreas. 2018 02; 47(2):158-162. PMID: 29346216.
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    15. Kaur K, Chang HH, Cook J, Eibl G, Jewett A. Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice. Front Immunol. 2017; 8:1606. PMID: 29255459.
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    16. Eibl G, Rozengurt E. KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops. Semin Cancer Biol. 2019 02; 54:50-62. PMID: 29079305.
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    17. Eibl G, Cruz-Monserrate Z, Korc M, Petrov MS, Goodarzi MO, Fisher WE, Habtezion A, Lugea A, Pandol SJ, Hart PA, Andersen DK. Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. J Acad Nutr Diet. 2018 04; 118(4):555-567. PMID: 28919082.
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    18. Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G. Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One. 2017; 12(9):e0184455. PMID: 28886117.
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    19. Andersen DK, Korc M, Petersen GM, Eibl G, Li D, Rickels MR, Chari ST, Abbruzzese JL. Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer. Diabetes. 2017 05; 66(5):1103-1110. PMID: 28507210.
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    20. Schmidt A, Sinnett-Smith J, Young S, Chang HH, Hines OJ, Dawson DW, Rozengurt E, Eibl G. Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. Surgery. 2017 06; 161(6):1570-1578. PMID: 28222855.
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    21. Yang J, Waldron RT, Su HY, Moro A, Chang HH, Eibl G, Ferreri K, Kandeel FR, Lugea A, Li L, Pandol SJ. Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G675-G687. PMID: 27609771.
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    22. Vorvis C, Hatziapostolou M, Mahurkar-Joshi S, Koutsioumpa M, Williams J, Donahue TR, Poultsides GA, Eibl G, Iliopoulos D. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G1124-37. PMID: 27151939.
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    23. Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G. Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas. 2016 Mar; 45(3):458-65. PMID: 26495779.
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    24. Stark AP, Sacks GD, Rochefort MM, Donahue TR, Reber HA, Tomlinson JS, Dawson DW, Eibl G, Hines OJ. Long-term survival in patients with pancreatic ductal adenocarcinoma. Surgery. 2016 06; 159(6):1520-1527. PMID: 26847803.
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    25. Birtolo C, Go VL, Ptasznik A, Eibl G, Pandol SJ. Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer. Pancreas. 2016 Jan; 45(1):21-31. PMID: 26658038.
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    26. Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G. Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1. Am J Physiol Cell Physiol. 2015 Nov 15; 309(10):C639-49. PMID: 26310818.
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    27. Stark AP, Chang HH, Jung X, Moro A, Hertzer K, Xu M, Schmidt A, Hines OJ, Eibl G. E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice. Surgery. 2015 Dec; 158(6):1564-72. PMID: 26297056.
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    28. Ming M, Sinnett-Smith J, Wang J, Soares HP, Young SH, Eibl G, Rozengurt E. Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. PLoS One. 2014; 9(12):e114573. PMID: 25493642.
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    29. Edderkaoui M, Eibl G. Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Front Physiol. 2014; 5:490. PMID: 25540626.
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    30. Edderkaoui M, Lugea A, Hui H, Eibl G, Lu QY, Moro A, Lu X, Li G, Go VL, Pandol SJ. Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells. Nutr Cancer. 2013; 65(8):1232-44. PMID: 24127740.
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    31. Lu QY, Zhang L, Eibl G, Go VL. Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue ß-glucuronidase. J Pharm Biomed Anal. 2014 Jan; 88:364-9. PMID: 24176739.
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    32. Pham H, Rodriguez CE, Donald GW, Hertzer KM, Jung XS, Chang HH, Moro A, Reber HA, Hines OJ, Eibl G. miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. Biochem Biophys Res Commun. 2013 Sep 13; 439(1):6-11. PMID: 23973710.
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    33. Takahashi H, Chen MC, Pham H, Matsuo Y, Ishiguro H, Reber HA, Takeyama H, Hines OJ, Eibl G. Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells. Biochim Biophys Acta. 2013 Dec; 1833(12):2980-2987. PMID: 23954445.
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    34. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct; 6(10):1064-73. PMID: 23943783.
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    35. Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT. Role of pancreatic cancer-derived exosomes in salivary biomarker development. J Biol Chem. 2013 Sep 13; 288(37):26888-97. PMID: 23880764.
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    36. Kisfalvi K, Moro A, Sinnett-Smith J, Eibl G, Rozengurt E. Metformin inhibits the growth of human pancreatic cancer xenografts. Pancreas. 2013 Jul; 42(5):781-5. PMID: 23462329.
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    37. Donald GW, Sunjaya D, Lu X, Chen F, Clerkin B, Eibl G, Li G, Tomlinson JS, Donahue TR, Reber HA, Hines OJ. Perioperative antibiotics for surgical site infection in pancreaticoduodenectomy: does the SCIP-approved regimen provide adequate coverage? Surgery. 2013 Aug; 154(2):190-6. PMID: 23664266.
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    38. Angst E, Park JL, Moro A, Lu QY, Lu X, Li G, King J, Chen M, Reber HA, Go VL, Eibl G, Hines OJ. The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas. 2013 Mar; 42(2):223-9. PMID: 23000892.
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    39. Lu QY, Zhang L, Lugea A, Moro A, Edderkaoui M, Eibl G, Pandol SJ, Go VL. Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method. J Chromatogr Sep Tech. 2013 Jan 01; 4(1). PMID: 24482742.
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    40. Donald G, Hertzer K, Eibl G. Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer. Curr Drug Targets. 2012 Dec; 13(14):1772-6. PMID: 23140288.
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    41. Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012 Nov; 41(8):1306-15. PMID: 22889981.
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    42. Lu QY, Zhang L, Moro A, Chen MC, Harris DM, Eibl G, Go VL. Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. Pancreas. 2012 May; 41(4):571-6. PMID: 22158070.
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    43. Pandol S, Gukovskaya A, Edderkaoui M, Edderkoui M, Dawson D, Eibl G, Lugea A. Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:127-34. PMID: 22320930.
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    44. King JC, Lu QY, Li G, Moro A, Takahashi H, Chen M, Go VL, Reber HA, Eibl G, Hines OJ. Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochim Biophys Acta. 2012 Feb; 1823(2):593-604. PMID: 22227579.
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    45. Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology. 2012 Feb; 142(2):377-87.e1-5. PMID: 22044669.
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    46. Assifi MM, Lu X, Eibl G, Reber HA, Li G, Hines OJ. Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials. Surgery. 2011 Sep; 150(3):466-73. PMID: 21878232.
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    47. Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1465-74. PMID: 21596068.
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    48. Takahashi H, Li A, Dawson DW, Hines OJ, Reber HA, Eibl G. Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. Pancreas. 2011 Apr; 40(3):453-9. PMID: 21343834.
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    49. Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. Am J Pathol. 2011 Mar; 178(3):1340-9. PMID: 21356384.
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    50. Li A, Cheng XJ, Moro A, Singh RK, Hines OJ, Eibl G. CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth. Transl Oncol. 2011 Feb 01; 4(1):20-8. PMID: 21286374.
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    51. Angst E, Dawson DW, Stroka D, Gloor B, Park J, Candinas D, Reber HA, Hines OJ, Eibl G. N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery. 2011 May; 149(5):614-24. PMID: 21236457.
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    52. Angst E, Chen M, Mojadidi M, Hines OJ, Reber HA, Eibl G. Bioluminescence imaging of angiogenesis in a murine orthotopic pancreatic cancer model. Mol Imaging Biol. 2010 Dec; 12(6):570-5. PMID: 20376570.
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    53. Donahue TR, Hines OJ, Farrell JJ, Tomlinson JS, Eibl G, Reber HA. Cystic neoplasms of the pancreas: results of 114 cases. Pancreas. 2010 Nov; 39(8):1271-6. PMID: 20717069.
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    54. Angst E, Dawson DW, Nguyen A, Park J, Go VL, Reber HA, Hines OJ, Eibl G. Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas. 2010 Jul; 39(5):675-9. PMID: 20173668.
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    55. Zhang L, Angst E, Park JL, Moro A, Dawson DW, Reber HA, Eibl G, Hines OJ, Go VL, Lu QY. Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. J Agric Food Chem. 2010 Jun 23; 58(12):7252-7. PMID: 20499918.
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    56. Pham H, Chen M, Li A, King J, Angst E, Dawson DW, Park J, Reber HA, Hines OJ, Eibl G. Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. Pancreas. 2010 Apr; 39(3):332-9. PMID: 19820419.
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    57. Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R, Goddard WA, Yokosuka O, Pandol SJ, Gukovskaya AS. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G63-73. PMID: 19762431.
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    58. Kisfalvi K, Eibl G, Sinnett-Smith J, Rozengurt E. Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res. 2009 Aug 15; 69(16):6539-45. PMID: 19679549.
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    59. Gao K, Zhou H, Zhang L, Lee JW, Zhou Q, Hu S, Wolinsky LE, Farrell J, Eibl G, Wong DT. Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One. 2009 Jun 11; 4(6):e5875. PMID: 19517020.
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    60. Hasan S, Satake M, Dawson DW, Funahashi H, Angst E, Go VL, Reber HA, Hines OJ, Eibl G. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas. 2008 Aug; 37(2):121-7. PMID: 18665070.
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    61. King J, Kazanjian K, Matsumoto J, Reber HA, Yeh MW, Hines OJ, Eibl G. Distal pancreatectomy: incidence of postoperative diabetes. J Gastrointest Surg. 2008 Sep; 12(9):1548-53. PMID: 18543045.
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    62. Angst E, Reber HA, Hines OJ, Eibl G. Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. Surgery. 2008 Jul; 144(1):57-65. PMID: 18571585.
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    63. Pham H, Eibl G, Vincenti R, Chong B, Tai HH, Slice LW. 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice. Mol Carcinog. 2008 Jun; 47(6):466-77. PMID: 18058808.
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    64. Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA, Hines OJ, Eibl G. Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas. 2008 May; 36(4):353-62. PMID: 18437081.
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    65. Eibl G. The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic Cancer. PPAR Res. 2008; 2008:326915. PMID: 18615182.
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    66. Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2007 Aug 01; 67(15):7068-71. PMID: 17652141.
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    67. Satake M, Sawai H, Go VL, Satake K, Reber HA, Hines OJ, Eibl G. Estrogen receptors in pancreatic tumors. Pancreas. 2006 Aug; 33(2):119-27. PMID: 16868476.
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    68. Sawai H, Liu J, Reber HA, Hines OJ, Eibl G. Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. Mol Cancer Res. 2006 Mar; 4(3):159-67. PMID: 16547153.
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    69. Sawai H, Okada Y, Kazanjian K, Kim J, Hasan S, Hines OJ, Reber HA, Hoon DS, Eibl G. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res. 2005 Dec 15; 65(24):11536-44. PMID: 16357163.
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    70. Wente MN, Eibl G, Reber HA, Friess H, Büchler MW, Hines OJ. The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells. Oncol Rep. 2005 Dec; 14(6):1635-8. PMID: 16273269.
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    71. Büchler P, Reber HA, Eibl G, Roth MA, Büchler MW, Friess H, Isacoff WH, Hines OJ. Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy. Int J Oncol. 2005 Oct; 27(4):1125-30. PMID: 16142331.
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    72. Eibl G, Reber HA. A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer. Pancreas. 2005 Oct; 31(3):258-62. PMID: 16163058.
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    73. Kazanjian KK, Hines OJ, Eibl G, Reber HA. Management of pancreatic fistulas after pancreaticoduodenectomy: results in 437 consecutive patients. Arch Surg. 2005 Sep; 140(9):849-54; discussion 854-6. PMID: 16172293.
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    74. Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res. 2005 Apr 01; 65(7):2738-45. PMID: 15805273.
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    75. Eibl G, Takata Y, Boros LG, Liu J, Okada Y, Reber HA, Hines OJ. Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res. 2005 Feb 01; 65(3):982-90. PMID: 15705899.
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    76. Eibl G, Reber HA, Hines OJ, Go VL. COX and PPAR: possible interactions in pancreatic cancer. Pancreas. 2004 Nov; 29(4):247-53. PMID: 15502639.
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    77. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ. Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis. 2004; 21(4):285-92. PMID: 15554384.
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    78. Okada Y, Eibl G, Duffy JP, Reber HA, Hines OJ. Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer. Surgery. 2003 Aug; 134(2):293-9. PMID: 12947332.
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    79. Eibl G, Bruemmer D, Okada Y, Duffy JP, Law RE, Reber HA, Hines OJ. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun. 2003 Jul 11; 306(4):887-97. PMID: 12821125.
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    80. Duffy JP, Eibl G, Reber HA, Hines OJ. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer. 2003 Jan 22; 2:12. PMID: 12605718.
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    81. Eibl G, Reber HA, Wente MN, Hines OJ. The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. Pancreas. 2003 Jan; 26(1):33-41. PMID: 12499915.
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    82. Foitzik T, Eibl G, Schneider P, Wenger FA, Jacobi CA, Buhr HJ. Omega-3 fatty acid supplementation increases anti-inflammatory cytokines and attenuates systemic disease sequelae in experimental pancreatitis. JPEN J Parenter Enteral Nutr. 2002 Nov-Dec; 26(6):351-6. PMID: 12405646.
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    83. Eibl G, Forgacs B, Hotz HG, Buhr HJ, Foitzik T. Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis. Pancreas. 2002 Aug; 25(2):e15-20. PMID: 12142750.
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    84. Eibl G, Buhr HJ, Foitzik T. Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block? Intensive Care Med. 2002 Feb; 28(2):139-46. PMID: 11907656.
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