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Guoping Fan

Title(s)Professor Emeritus, Human Genetics
SchoolMedicine
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    Collapse Research 
    Collapse research activities and funding
    Dissecting molecular pathways underlying Human Overgrowth Syndrome
    NIH R01DE025474Jul 5, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Elucidating molecular basis of ICF Syndrome with human pluripotent stem cells
    NIH R21DE022928Dec 1, 2012 - Nov 30, 2014
    Role: Principal Investigator
    Mapping DNA methylation in hippocampal neurons through bisulfite sequencing
    NIH R21NS072924Jan 15, 2011 - Dec 31, 2012
    Role: Principal Investigator
    DNA HYPOMETHYLATION AND CORTICAL NEURONAL DEGENERATION
    NIH R56NS051411Mar 15, 2005 - Aug 31, 2011
    Role: Principal Investigator
    DNA Hypomethylation and Cortical Neuronal Degeneration
    NIH R01NS051411Mar 15, 2005 - Aug 31, 2010
    Role: Principal Investigator
    DNA methylation in Neuronal and Glial Differentiation
    NIH R01NS044405May 1, 2003 - Apr 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation. Mol Cell. 2025 May 15; 85(10):1999-2016.e11. Wang J, Deng X, Jian T, Yin S, Chen L, Vergnes L, Li Z, Liu H, Lee R, Lim SY, Bahn JH, Xiao X, Zhu X, Hu G, Reue K, Liu Y, Fan G. PMID: 40328247.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Differentiation of human induced pluripotent stem cells into retinal pigment epithelium cells during culture on peptide-grafted hydrogels. Regen Biomater. 2025; 12:rbaf035. Liu J, Liu Q, Guo M, Jiang C, Chen J, Wang T, Sung TC, Chou SJ, Chiou SH, Fan G, Higuchi A. PMID: 40416648; PMCID: PMC12098265.
      View in: PubMed   Mentions:
    3. Tuning up gene transcription via direct crosstalk of DNA and RNA methylation. Mol Cell. 2025 Feb 20; 85(4):674-676. Deng X, Fan G. PMID: 39983671.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing. Int J Mol Sci. 2024 Sep 15; 25(18). Zhang W, Qian S, Chen J, Jian T, Wang X, Zhu X, Dong Y, Fan G. PMID: 39337435; PMCID: PMC11432402.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids. Nat Commun. 2024 09 13; 15(1):8022. Zhang S, Xiao Y, Mo X, Chen X, Zhong J, Chen Z, Liu X, Qiu Y, Dai W, Chen J, Jin X, Fan G, Hu Y. PMID: 39271703; PMCID: PMC11399327.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Effects of ECM protein-coated surfaces on the generation of retinal pigment epithelium cells differentiated from human pluripotent stem cells. Regen Biomater. 2024; 11:rbae091. Tian Z, Liu Q, Lin HY, Zhu YR, Ling L, Sung TC, Wang T, Li W, Gao M, Cheng S, Renuka RR, Subbiah SK, Fan G, Wu GJ, Higuchi A. PMID: 39233867; PMCID: PMC11374035.
      View in: PubMed   Mentions: 3  
    7. Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model. J Transl Med. 2023 12 14; 21(1):910. Liu Q, Liu J, Guo M, Sung TC, Wang T, Yu T, Tian Z, Fan G, Wu W, Higuchi A. PMID: 38098048; PMCID: PMC10720187.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation. Nat Commun. 2023 11 29; 14(1):7829. Ma L, Wang F, Li Y, Wang J, Chang Q, Du Y, Sadan J, Zhao Z, Fan G, Yao B, Chen JF. PMID: 38030616; PMCID: PMC10687003.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Single-Cell RNA-Sequencing Provides Insight into Skeletal Muscle Evolution during the Selection of Muscle Characteristics. Adv Sci (Weinh). 2023 12; 10(35):e2305080. Xu D, Wan B, Qiu K, Wang Y, Zhang X, Jiao N, Yan E, Wu J, Yu R, Gao S, Du M, Liu C, Li M, Fan G, Yin J. PMID: 37870215; PMCID: PMC10724408.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    10. Chemical-induced phase transition and global conformational reorganization of chromatin. Nat Commun. 2023 09 09; 14(1):5556. Wang T, Shi S, Shi Y, Jiang P, Hu G, Ye Q, Shi Z, Yu K, Wang C, Fan G, Zhao S, Ma H, Chang ACY, Li Z, Bian Q, Lin CP. PMID: 37689690; PMCID: PMC10492836.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    11. Culture conditions of mouse ESCs impact the tumor appearance in vivo. Cell Rep. 2023 06 27; 42(6):112645. Tian C, Wang J, Ye X, Chen J, Zheng R, Yu H, Li J, Yin G, Liu L, Zhao N, Feng G, Zhu Z, Wang J, Fan G, Liu L. PMID: 37314926.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury. JCI Insight. 2022 10 24; 7(20). Ding X, An Q, Zhao W, Song Y, Tang X, Wang J, Chang CC, Zhao G, Hsiai T, Fan G, Fan Y, Li S. PMID: 36278486; PMCID: PMC9714785.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Global Transcriptional and Epigenetic Reconfiguration during Chemical Reprogramming of Human Retinal Pigment Epithelial Cells into Photoreceptor-like Cells. Cells. 2022 10 06; 11(19). Deng X, Lee R, Lim SY, Zhong Z, Wang J, Liu Y, Fan G. PMID: 36231108; PMCID: PMC9564162.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo. J Mol Biol. 2021 09 17; 433(19):167166. Jansova D, Aleshkina D, Jindrova A, Iyyappan R, An Q, Fan G, Susor A. PMID: 34293340.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO Rep. 2021 08 04; 22(8):e51978. Ma L, Wang J, Ge J, Wang Y, Zhang W, Du Y, Luo J, Li Y, Wang F, Fan G, Chen R, Yao B, Zhao Z, Guo ML, Kim WK, Chai Y, Chen JF. PMID: 34232545; PMCID: PMC8344882.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Organoids as Novel Models for Embryo Implantation Study. Reprod Sci. 2021 06; 28(6):1637-1643. Wei Y, Zhang C, Fan G, Meng L. PMID: 33650092.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Asymmetric Cell Division of Fibroblasts is An Early Deterministic Step to Generate Elite Cells during Cell Reprogramming. Adv Sci (Weinh). 2021 04; 8(7):2003516. Song Y, Soto J, Wang P, An Q, Zhang X, Hong S, Lee LP, Fan G, Yang L, Li S. PMID: 33854891; PMCID: PMC8025021.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging. Cell Stem Cell. 2021 06 03; 28(6):1057-1073.e7. Deng P, Yuan Q, Cheng Y, Li J, Liu Z, Liu Y, Li Y, Su T, Wang J, Salvo ME, Wang W, Fan G, Lyons K, Yu B, Wang CY. PMID: 33571444; PMCID: PMC8178178.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    19. Single-cell analysis of nonhuman primate preimplantation development in comparison to humans and mice. Dev Dyn. 2021 07; 250(7):974-985. Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G. PMID: 33449399.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. Exp Biol Med (Maywood). 2021 03; 246(6):678-687. Lu P, Yang G, Jiang L, He W, Wu W, Qi L, Shen S, Rao J, Zhang P, Xue Z, Jiang C, Fan G, Zhu X. PMID: 33302736; PMCID: PMC7988730.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. Oncogene. 2021 01; 40(2):355-368. He D, Wang D, Lu P, Yang N, Xue Z, Zhu X, Zhang P, Fan G. PMID: 33144684; PMCID: PMC7808940.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    22. Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation. Nat Commun. 2020 10 13; 11(1):5148. Hu Y, Zhong J, Xiao Y, Xing Z, Sheu K, Fan S, An Q, Qiu Y, Zheng Y, Liu X, Fan G, Liu Y. PMID: 33051455; PMCID: PMC7555861.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    23. Stem cell-based treatment of kidney diseases. Exp Biol Med (Maywood). 2020 05; 245(10):902-910. Pan B, Fan G. PMID: 32281411; PMCID: PMC7268929.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    24. Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses. PLoS Biol. 2019 10; 17(10):e3000187. Lv B, An Q, Zeng Q, Zhang X, Lu P, Wang Y, Zhu X, Ji Y, Fan G, Xue Z. PMID: 31596842; PMCID: PMC6802852.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    25. The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients. Precis Clin Med. 2019 Sep; 2(3):131-139. An Q, Hu Y, Li Q, Chen X, Huang J, Pellegrini M, Zhou XJ, Rettig M, Fan G. PMID: 31598384; PMCID: PMC6770274.
      View in: PubMed   Mentions: 17  
    26. Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis. Stem Cell Reports. 2019 10 08; 13(4):747-760. Mao X, An Q, Xi H, Yang XJ, Zhang X, Yuan S, Wang J, Hu Y, Liu Q, Fan G. PMID: 31543471; PMCID: PMC6829752.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    27. Multimodal imaging of the retina and choroid in healthy Macaca fascicularis at different ages. Graefes Arch Clin Exp Ophthalmol. 2019 Mar; 257(3):455-463. Fan S, Ding X, Rao P, Zheng Y, Mao F, Hu Y, Liu X, Fan G. PMID: 30684011.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    28. Simultaneous Profiling of mRNA Transcriptome and DNA Methylome from a Single Cell. Methods Mol Biol. 2019; 1979:363-377. Hu Y, An Q, Guo Y, Zhong J, Fan S, Rao P, Liu X, Liu Y, Fan G. PMID: 31028648.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature. 2018 12; 564(7734):136-140. Li Y, Zhang Z, Chen J, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu GL, Wang Z, Wang H, Gao S, Zhu B. PMID: 30487604.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    30. Alpha-fetoprotein response following transarterial chemoembolization indicates improved survival for intermediate-stage hepatocellular carcinoma. HPB (Oxford). 2019 01; 21(1):107-113. Liu G, Ouyang Q, Xia F, Fan G, Yu J, Zhang C, Wang D. PMID: 30017783.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    31. Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor. Sci Rep. 2018 03 05; 8(1):4004. Yang J, Yi N, Zhang J, He W, He D, Wu W, Xu S, Li F, Fan G, Zhu X, Xue Z, Zhou W. PMID: 29507327; PMCID: PMC5838214.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    32. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8. Kidney Int. 2017 11; 92(5):1194-1205. Guo C, Pei L, Xiao X, Wei Q, Chen JK, Ding HF, Huang S, Fan G, Shi H, Dong Z. PMID: 28709638; PMCID: PMC5651199.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    33. Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84. Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. PMID: 28482897; PMCID: PMC5421338.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimals
    34. The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences. Genome Res. 2016 12; 26(12):1651-1662. Xue C, Raveendran M, Harris RA, Fawcett GL, Liu X, White S, Dahdouli M, Rio Deiros D, Below JE, Salerno W, Cox L, Fan G, Ferguson B, Horvath J, Johnson Z, Kanthaswamy S, Kubisch HM, Liu D, Platt M, Smith DG, Sun B, Vallender EJ, Wang F, Wiseman RW, Chen R, Muzny DM, Gibbs RA, Yu F, Rogers J. PMID: 27934697; PMCID: PMC5131817.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    35. Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation. Sci China Life Sci. 2016 Nov; 59(11):1093-1105. Lu P, Chen X, Feng Y, Zeng Q, Jiang C, Zhu X, Fan G, Xue Z. PMID: 27730449.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    36. Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2016 09 27; 17(1):289-302. King AD, Huang K, Rubbi L, Liu S, Wang CY, Wang Y, Pellegrini M, Fan G. PMID: 27681438; PMCID: PMC5507178.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    37. Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Sci Rep. 2016 08 25; 6:31851. Hu G, Huang K, Hu Y, Du G, Xue Z, Zhu X, Fan G. PMID: 27558660; PMCID: PMC4997251.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    38. Directed differentiation of human embryonic stem cells to corneal endothelial cell-like cells: A transcriptomic analysis. Exp Eye Res. 2016 10; 151:107-14. Song Q, Yuan S, An Q, Chen Y, Mao FF, Liu Y, Liu Q, Fan G. PMID: 27523468.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    39. The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat. Sci Rep. 2016 07 05; 6:28508. Xu S, Zhu X, Li H, Hu Y, Zhou J, He D, Feng Y, Lu L, Du G, Hu Y, Liu T, Wang Z, Ding G, Chen J, Gao S, Wu F, Xue Z, Li Y, Fan G. PMID: 27378381; PMCID: PMC4932527.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. Bisphenol A Represses Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells through Downregulating the Expression of Insulin-like Growth Factor 1. Mol Neurobiol. 2017 07; 54(5):3798-3812. Huang B, Ning S, Zhang Q, Chen A, Jiang C, Cui Y, Hu J, Li H, Fan G, Qin L, Liu J. PMID: 27271280.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    41. Recent advances in preimplantation genetic diagnosis and screening. J Assist Reprod Genet. 2016 Sep; 33(9):1129-34. Lu L, Lv B, Huang K, Xue Z, Zhu X, Fan G. PMID: 27272212; PMCID: PMC5010808.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    42. Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity. Nat Immunol. 2016 07; 17(7):806-15. Li X, Zhang Q, Ding Y, Liu Y, Zhao D, Zhao K, Shen Q, Liu X, Zhu X, Li N, Cheng Z, Fan G, Wang Q, Cao X. PMID: 27240213.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    43. Simultaneous profiling of transcriptome and DNA methylome from a single cell. Genome Biol. 2016 May 05; 17:88. Hu Y, Huang K, An Q, Du G, Hu G, Xue J, Zhu X, Wang CY, Xue Z, Fan G. PMID: 27150361; PMCID: PMC4858893.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    44. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016 Apr 26; 15(4):748-760. Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJM, Fan G, Zhu J, Dupree JL, Casaccia P. PMID: 27149841; PMCID: PMC5063656.
      View in: PubMed   Mentions: 61     Fields:    
    45. Ethanol Inactivated Mouse Embryonic Fibroblasts Maintain the Self-Renew and Proliferation of Human Embryonic Stem Cells. PLoS One. 2015; 10(6):e0130332. Huang B, Ning S, Zhuang L, Jiang C, Cui Y, Fan G, Qin L, Liu J. PMID: 26091287; PMCID: PMC4474813.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. Stem cell-based therapy of corneal epithelial and endothelial diseases. Regen Med. 2015 May; 10(4):495-504. Yuan S, Fan G. PMID: 26022766.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    47. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat Neurosci. 2015 Apr; 18(4):536-44. Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ. PMID: 25774451; PMCID: PMC4617315.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    48. Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells. Small. 2015 Jun 03; 11(21):2499-504. Hou S, Choi JS, Chen KJ, Zhang Y, Peng J, Garcia MA, Yu JH, Thakore-Shah K, Ro T, Chen JF, Peyda P, Fan G, Pyle AD, Wang H, Tseng HR. PMID: 25613059; PMCID: PMC4961214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    49. Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. J Neurosci. 2014 Nov 12; 34(46):15288-96. Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK. PMID: 25392496; PMCID: PMC4228132.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    50. The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses. Cell Stem Cell. 2014 Oct 02; 15(4):410-415. Huang K, Maruyama T, Fan G. PMID: 25280217; PMCID: PMC5507179.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    51. Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells. Stem Cell Reports. 2014 Sep 09; 3(3):460-74. Zhang X, Li B, Li W, Ma L, Zheng D, Li L, Yang W, Chu M, Chen W, Mailman RB, Zhu J, Fan G, Archer TK, Wang Y. PMID: 25241744; PMCID: PMC4266000.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    52. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Mol Syst Biol. 2014 Jul 30; 10:743. Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J. PMID: 25080494; PMCID: PMC4299500.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    53. Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells. Hum Mol Genet. 2014 Dec 15; 23(24):6448-57. Huang K, Wu Z, Liu Z, Hu G, Yu J, Chang KH, Kim KP, Le T, Faull KF, Rao N, Gennery A, Xue Z, Wang CY, Pellegrini M, Fan G. PMID: 25027325; PMCID: PMC4240200.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    54. Integrated analysis of DNA methylation and RNA transcriptome during in vitro differentiation of human pluripotent stem cells into retinal pigment epithelial cells. PLoS One. 2014; 9(3):e91416. Liu Z, Jiang R, Yuan S, Wang N, Feng Y, Hu G, Zhu X, Huang K, Ma J, Xu G, Liu Q, Xue Z, Fan G. PMID: 24638073; PMCID: PMC3956675.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    55. PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One. 2014; 9(2):e89464. Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K. PMID: 24586797; PMCID: PMC3933565.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    56. A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells. Stem Cell Reports. 2014 Jan 14; 2(1):36-43. Huang K, Shen Y, Xue Z, Bibikova M, April C, Liu Z, Cheng L, Nagy A, Pellegrini M, Fan JB, Fan G. PMID: 24511466; PMCID: PMC3916755.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    57. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci. 2014 Feb; 17(2):215-22. Guo JU, Su Y, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. PMID: 24362762; PMCID: PMC3970219.
      View in: PubMed   Mentions: 433     Fields:    Translation:HumansAnimalsCells
    58. Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature. 2013 Aug 29; 500(7464):593-7. Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G. PMID: 23892778; PMCID: PMC4950944.
      View in: PubMed   Mentions: 503     Fields:    Translation:HumansAnimalsCells
    59. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell. 2013 Apr 04; 12(4):470-8. Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. PMID: 23415914; PMCID: PMC3684274.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    60. Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells. Hum Mol Genet. 2013 Apr 01; 22(7):1271-9. Chen Y, Huang K, Nakatsu MN, Xue Z, Deng SX, Fan G. PMID: 23257286; PMCID: PMC3596846.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    61. Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells. PLoS One. 2012; 7(7):e37224. Hu G, Huang K, Yu J, Gopalakrishna-Pillai S, Kong J, Xu H, Liu Z, Zhang K, Xu J, Luo Y, Li S, Sun YE, Iverson LE, Xue Z, Fan G. PMID: 22848339; PMCID: PMC3407211.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    62. DNA methylation and its basic function. Neuropsychopharmacology. 2013 Jan; 38(1):23-38. Moore LD, Le T, Fan G. PMID: 22781841; PMCID: PMC3521964.
      View in: PubMed   Mentions: 2109     Fields:    Translation:HumansAnimalsCells
    63. Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol. 2012 Dec; 132(12):2681-90. Li J, Jiang TX, Hughes MW, Wu P, Yu J, Widelitz RB, Fan G, Chuong CM. PMID: 22763785; PMCID: PMC3465630.
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    64. Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. J Neurosci Res. 2012 Oct; 90(10):1883-91. Wu Z, Huang K, Yu J, Le T, Namihira M, Liu Y, Zhang J, Xue Z, Cheng L, Fan G. PMID: 22714992; PMCID: PMC3418436.
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    65. Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor. Biomaterials. 2012 Jul; 33(21):5459-67. Biswas A, Liu Y, Liu T, Fan G, Tang Y. PMID: 22521490.
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    66. Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories. Front Behav Neurosci. 2012; 6:3. Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS. PMID: 22347173; PMCID: PMC3270585.
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    67. Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells. Stem Cells Dev. 2011 Nov; 20(11):1937-50. Wang A, Huang K, Shen Y, Xue Z, Cai C, Horvath S, Fan G. PMID: 21542696; PMCID: PMC3202894.
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    68. X chromosome inactivation in human and mouse pluripotent stem cells. Hum Genet. 2011 Aug; 130(2):217-22. Fan G, Tran J. PMID: 21678064; PMCID: PMC3965368.
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    69. Epigenetic modifications in distinction: histone versus DNA methylation in ESCs. Cell Stem Cell. 2011 Jun 03; 8(6):604-5. Huang K, Fan G. PMID: 21624801.
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    70. Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. PMID: 21497756; PMCID: PMC3086024.
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    71. Endoprotease-mediated intracellular protein delivery using nanocapsules. ACS Nano. 2011 Feb 22; 5(2):1385-94. Biswas A, Joo KI, Liu J, Zhao M, Fan G, Wang P, Gu Z, Tang Y. PMID: 21268592.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    72. A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples. Anal Biochem. 2011 May 15; 412(2):203-9. Le T, Kim KP, Fan G, Faull KF. PMID: 21272560; PMCID: PMC3070205.
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    73. Evaluation of x-inactivation status and cytogenetic stability of human dermal fibroblasts after long-term culture. Int J Cell Biol. 2010; 2010:289653. Chen J, Shi ZP, Dong J, Liao TT, Wang YP, Sun XP, Yan ZJ, Qian XQ, Cui YG, Xue ZG, Fan G, Liu JY. PMID: 21234375; PMCID: PMC3017890.
      View in: PubMed   Mentions: 8  
    74. The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science. 2010 Oct 22; 330(6003):521-5. Liu B, Tahk S, Yee KM, Fan G, Shuai K. PMID: 20966256; PMCID: PMC3043201.
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    75. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet. 2010 Nov 01; 19(21):4229-38. Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. PMID: 20709808; PMCID: PMC3115666.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    76. DNA methylation in cell differentiation and reprogramming: an emerging systematic view. Regen Med. 2010 Jul; 5(4):531-44. Huang K, Fan G. PMID: 20632857.
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    77. Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells. PLoS One. 2010 Jun 25; 5(6):e11330. Dvash T, Lavon N, Fan G. PMID: 20593031; PMCID: PMC2892515.
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    78. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair. 2010 Sep; 24(7):636-44. Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. PMID: 20424193; PMCID: PMC4697440.
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    79. Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism. J Biol Chem. 2010 Jul 02; 285(27):21082-91. Hutnick LK, Huang X, Loo TC, Ma Z, Fan G. PMID: 20404320; PMCID: PMC2898347.
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    80. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr; 13(4):423-30. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. PMID: 20228804; PMCID: PMC3060772.
      View in: PubMed   Mentions: 531     Fields:    Translation:AnimalsCells
    81. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics. 2009 Jul 20; 10:327. Mason MJ, Fan G, Plath K, Zhou Q, Horvath S. PMID: 19619308; PMCID: PMC2727539.
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    82. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol. 2009 Aug; 11(8):1002-9. Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Shi S, Wang CY. PMID: 19578371; PMCID: PMC2752141.
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    83. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009 Aug 01; 18(15):2875-88. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. PMID: 19433415; PMCID: PMC2706688.
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    84. Epigenetic regulation of X-inactivation in human embryonic stem cells. Epigenetics. 2009 Jan; 4(1):19-22. Dvash T, Fan G. PMID: 19106643.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    85. The role of DNA methylation in the central nervous system and neuropsychiatric disorders. Int Rev Neurobiol. 2009; 89:67-84. Feng J, Fan G. PMID: 19900616.
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    86. Genome-wide DNA methylation profiling: the mDIP-chip technology. Methods Mol Biol. 2009; 568:203-16. Shen Y, Fouse SD, Fan G. PMID: 19582429.
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    87. Copy number variant analysis of human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1484-9. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. PMID: 18369100; PMCID: PMC3901366.
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    88. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4709-14. Shen Y, Matsuno Y, Fouse SD, Rao N, Root S, Xu R, Pellegrini M, Riggs AD, Fan G. PMID: 18339804; PMCID: PMC2290804.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    89. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell. 2008 Feb 07; 2(2):160-9. Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, Jaenisch R, Fan G. PMID: 18371437; PMCID: PMC3070208.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    90. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1026-31. Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J, Biancotti JC, Hutnick L, Krueger RC, Fan G, de Vellis J, Sun YE. PMID: 18195354; PMCID: PMC2242680.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    91. Epigenetic regulation of neural gene expression and neuronal function. Pediatr Res. 2007 May; 61(5 Pt 2):58R-63R. Feng J, Fouse S, Fan G. PMID: 17413844.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    92. Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification. J Biol Chem. 2006 Dec 22; 281(51):39081-7. Lu YC, Song J, Cho HY, Fan G, Yokoyama KK, Chiu R. PMID: 17071620.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    93. Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Hum Mol Genet. 2006 Sep 01; 15(17):2623-35. Shen Y, Chow J, Wang Z, Fan G. PMID: 16870691.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    94. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus Relat Syst. 2005 Sep; 3(3):227-233. Golshani P, Hutnick L, Schweizer F, Fan G. PMID: 17710197; PMCID: PMC1948851.
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    95. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 2005 Aug; 132(15):3345-56. Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE. PMID: 16014513.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    96. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005 May; 8(5):616-25. He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. PMID: 15852015; PMCID: PMC4222251.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    97. Methyl-CpG binding proteins in the nervous system. Cell Res. 2005 Apr; 15(4):255-61. Fan G, Hutnick L. PMID: 15857580.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    98. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005 Mar 15; 79(6):734-46. Feng J, Chang H, Li E, Fan G. PMID: 15672446.
      View in: PubMed   Mentions: 220     Fields:    Translation:AnimalsCells
    99. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003 Oct 31; 302(5646):890-3. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. PMID: 14593184.
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    100. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res. 2002 Sep 15; 69(6):848-60. Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE. PMID: 12205678.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
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