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Guoping Fan

Title(s)Professor, Human Genetics
SchoolMedicine
Address695 Charles E. Young Drive, So 6506
Los Angeles CA 90024
Phone3102670439
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    Collapse Research 
    Collapse Research Activities and Funding
    Dissecting molecular pathways underlying Human Overgrowth Syndrome
    NIH R01DE025474Jul 5, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Elucidating molecular basis of ICF Syndrome with human pluripotent stem cells
    NIH R21DE022928Dec 1, 2012 - Nov 30, 2014
    Role: Principal Investigator
    Mapping DNA methylation in hippocampal neurons through bisulfite sequencing
    NIH R21NS072924Jan 15, 2011 - Dec 31, 2012
    Role: Principal Investigator
    DNA HYPOMETHYLATION AND CORTICAL NEURONAL DEGENERATION
    NIH R56NS051411Mar 15, 2005 - Aug 31, 2011
    Role: Principal Investigator
    DNA Hypomethylation and Cortical Neuronal Degeneration
    NIH R01NS051411Mar 15, 2005 - Aug 31, 2010
    Role: Principal Investigator
    DNA methylation in Neuronal and Glial Differentiation
    NIH R01NS044405May 1, 2003 - Apr 30, 2009
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging. Cell Stem Cell. 2021 Feb 04. Deng P, Yuan Q, Cheng Y, Li J, Liu Z, Liu Y, Li Y, Su T, Wang J, Salvo ME, Wang W, Fan G, Lyons K, Yu B, Wang CY. PMID: 33571444.
      View in: PubMed   Mentions:    Fields:    
    2. The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients. Precis Clin Med. 2019 Sep; 2(3):131-139. An Q, Hu Y, Li Q, Chen X, Huang J, Pellegrini M, Zhou XJ, Rettig M, Fan G. PMID: 31598384.
      View in: PubMed   Mentions:
    3. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8. Kidney Int. 2017 11; 92(5):1194-1205. Guo C, Pei L, Xiao X, Wei Q, Chen JK, Ding HF, Huang S, Fan G, Shi H, Dong Z. PMID: 28709638.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    4. Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2016 09 27; 17(1):289-302. King AD, Huang K, Rubbi L, Liu S, Wang CY, Wang Y, Pellegrini M, Fan G. PMID: 27681438.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    5. Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. J Neurosci. 2014 Nov 12; 34(46):15288-96. Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK. PMID: 25392496.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses. Cell Stem Cell. 2014 Oct 02; 15(4):410-415. Huang K, Maruyama T, Fan G. PMID: 25280217.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    7. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Mol Syst Biol. 2014 Jul 30; 10:743. Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J. PMID: 25080494.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    8. Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells. Hum Mol Genet. 2014 Dec 15; 23(24):6448-57. Huang K, Wu Z, Liu Z, Hu G, Yu J, Chang KH, Kim KP, Le T, Faull KF, Rao N, Gennery A, Xue Z, Wang CY, Pellegrini M, Fan G. PMID: 25027325.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    9. PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One. 2014; 9(2):e89464. Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K. PMID: 24586797.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    10. A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells. Stem Cell Reports. 2014 Jan 14; 2(1):36-43. Huang K, Shen Y, Xue Z, Bibikova M, April C, Liu Z, Cheng L, Nagy A, Pellegrini M, Fan JB, Fan G. PMID: 24511466.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    11. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci. 2014 Feb; 17(2):215-22. Guo JU, Su Y, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. PMID: 24362762.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansAnimalsCells
    12. Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature. 2013 Aug 29; 500(7464):593-7. Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G. PMID: 23892778.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    13. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell. 2013 Apr 04; 12(4):470-8. Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. PMID: 23415914.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    14. Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells. PLoS One. 2012; 7(7):e37224. Hu G, Huang K, Yu J, Gopalakrishna-Pillai S, Kong J, Xu H, Liu Z, Zhang K, Xu J, Luo Y, Li S, Sun YE, Iverson LE, Xue Z, Fan G. PMID: 22848339.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    15. DNA methylation and its basic function. Neuropsychopharmacology. 2013 Jan; 38(1):23-38. Moore LD, Le T, Fan G. PMID: 22781841.
      View in: PubMed   Mentions: 357     Fields:    Translation:HumansAnimalsCells
    16. Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol. 2012 Dec; 132(12):2681-90. Li J, Jiang TX, Hughes MW, Wu P, Yu J, Widelitz RB, Fan G, Chuong CM. PMID: 22763785.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. J Neurosci Res. 2012 Oct; 90(10):1883-91. Wu Z, Huang K, Yu J, Le T, Namihira M, Liu Y, Zhang J, Xue Z, Cheng L, Fan G. PMID: 22714992.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    18. Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor. Biomaterials. 2012 Jul; 33(21):5459-67. Biswas A, Liu Y, Liu T, Fan G, Tang Y. PMID: 22521490.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells. Stem Cells Dev. 2011 Nov; 20(11):1937-50. Wang A, Huang K, Shen Y, Xue Z, Cai C, Horvath S, Fan G. PMID: 21542696.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    20. X chromosome inactivation in human and mouse pluripotent stem cells. Hum Genet. 2011 Aug; 130(2):217-22. Fan G, Tran J. PMID: 21678064.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Epigenetic modifications in distinction: histone versus DNA methylation in ESCs. Cell Stem Cell. 2011 Jun 03; 8(6):604-5. Huang K, Fan G. PMID: 21624801.
      View in: PubMed   Mentions: 1     Fields:    
    22. Pancreatic ß cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. PMID: 21497756.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    23. Endoprotease-mediated intracellular protein delivery using nanocapsules. ACS Nano. 2011 Feb 22; 5(2):1385-94. Biswas A, Joo KI, Liu J, Zhao M, Fan G, Wang P, Gu Z, Tang Y. PMID: 21268592.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples. Anal Biochem. 2011 May 15; 412(2):203-9. Le T, Kim KP, Fan G, Faull KF. PMID: 21272560.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    25. The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science. 2010 Oct 22; 330(6003):521-5. Liu B, Tahk S, Yee KM, Fan G, Shuai K. PMID: 20966256.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    26. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet. 2010 Nov 01; 19(21):4229-38. Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. PMID: 20709808.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    27. DNA methylation in cell differentiation and reprogramming: an emerging systematic view. Regen Med. 2010 Jul; 5(4):531-44. Huang K, Fan G. PMID: 20632857.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    28. Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells. PLoS One. 2010 Jun 25; 5(6):e11330. Dvash T, Lavon N, Fan G. PMID: 20593031.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    29. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair. 2010 Sep; 24(7):636-44. Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. PMID: 20424193.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    30. Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism. J Biol Chem. 2010 Jul 02; 285(27):21082-91. Hutnick LK, Huang X, Loo TC, Ma Z, Fan G. PMID: 20404320.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    31. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr; 13(4):423-30. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. PMID: 20228804.
      View in: PubMed   Mentions: 358     Fields:    Translation:AnimalsCells
    32. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics. 2009 Jul 20; 10:327. Mason MJ, Fan G, Plath K, Zhou Q, Horvath S. PMID: 19619308.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    33. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol. 2009 Aug; 11(8):1002-9. Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Shi S, Wang CY. PMID: 19578371.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    34. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009 Aug 01; 18(15):2875-88. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. PMID: 19433415.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    35. Epigenetic regulation of X-inactivation in human embryonic stem cells. Epigenetics. 2009 Jan; 4(1):19-22. Dvash T, Fan G. PMID: 19106643.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. The role of DNA methylation in the central nervous system and neuropsychiatric disorders. Int Rev Neurobiol. 2009; 89:67-84. Feng J, Fan G. PMID: 19900616.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    37. Genome-wide DNA methylation profiling: the mDIP-chip technology. Methods Mol Biol. 2009; 568:203-16. Shen Y, Fouse SD, Fan G. PMID: 19582429.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Copy number variant analysis of human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1484-9. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. PMID: 18369100.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4709-14. Shen Y, Matsuno Y, Fouse SD, Rao N, Root S, Xu R, Pellegrini M, Riggs AD, Fan G. PMID: 18339804.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    40. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell. 2008 Feb 07; 2(2):160-9. Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, Jaenisch R, Fan G. PMID: 18371437.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    41. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1026-31. Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J, Biancotti JC, Hutnick L, Krueger RC, Fan G, de Vellis J, Sun YE. PMID: 18195354.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    42. Epigenetic regulation of neural gene expression and neuronal function. Pediatr Res. 2007 May; 61(5 Pt 2):58R-63R. Feng J, Fouse S, Fan G. PMID: 17413844.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    43. Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification. J Biol Chem. 2006 Dec 22; 281(51):39081-7. Lu YC, Song J, Cho HY, Fan G, Yokoyama KK, Chiu R. PMID: 17071620.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Hum Mol Genet. 2006 Sep 01; 15(17):2623-35. Shen Y, Chow J, Wang Z, Fan G. PMID: 16870691.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    45. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus Relat Syst. 2005 Sep; 3(3):227-233. Golshani P, Hutnick L, Schweizer F, Fan G. PMID: 17710197.
      View in: PubMed   Mentions:
    46. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 2005 Aug; 132(15):3345-56. Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE. PMID: 16014513.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    47. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005 May; 8(5):616-25. He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. PMID: 15852015.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    48. Methyl-CpG binding proteins in the nervous system. Cell Res. 2005 Apr; 15(4):255-61. Fan G, Hutnick L. PMID: 15857580.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    49. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005 Mar 15; 79(6):734-46. Feng J, Chang H, Li E, Fan G. PMID: 15672446.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    50. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003 Oct 31; 302(5646):890-3. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. PMID: 14593184.
      View in: PubMed   Mentions: 517     Fields:    Translation:AnimalsCells
    51. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res. 2002 Sep 15; 69(6):848-60. Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE. PMID: 12205678.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
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