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Fan, Guoping

Title(s)Professor, Human Genetics
Phone3102670439
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    Collapse Research 
    Collapse Research Activities and Funding
    Dissecting molecular pathways underlying Human Overgrowth Syndrome
    NIH/NIDCR R01DE025474Jul 5, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Elucidating molecular basis of ICF Syndrome with human pluripotent stem cells
    NIH/NIDCR R21DE022928Dec 1, 2012 - Nov 30, 2014
    Role: Principal Investigator
    Mapping DNA methylation in hippocampal neurons through bisulfite sequencing
    NIH/NINDS R21NS072924Jan 15, 2011 - Dec 31, 2012
    Role: Principal Investigator
    DNA HYPOMETHYLATION AND CORTICAL NEURONAL DEGENERATION
    NIH/NINDS R56NS051411Mar 15, 2005 - Aug 31, 2011
    Role: Principal Investigator
    DNA Hypomethylation and Cortical Neuronal Degeneration
    NIH/NINDS R01NS051411Mar 15, 2005 - Feb 28, 2010
    Role: Principal Investigator
    DNA methylation in Neuronal and Glial Differentiation
    NIH/NINDS R01NS044405May 1, 2003 - Apr 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. An Q, Hu Y, Li Q, Chen X, Huang J, Pellegrini M, Zhou XJ, Rettig M, Fan G. The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients. Precis Clin Med. 2019 Sep; 2(3):131-139. PMID: 31598384.
      View in: PubMed
    2. Guo C, Pei L, Xiao X, Wei Q, Chen JK, Ding HF, Huang S, Fan G, Shi H, Dong Z. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8. Kidney Int. 2017 11; 92(5):1194-1205. PMID: 28709638.
      View in: PubMed
    3. King AD, Huang K, Rubbi L, Liu S, Wang CY, Wang Y, Pellegrini M, Fan G. Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2016 09 27; 17(1):289-302. PMID: 27681438.
      View in: PubMed
    4. Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK. Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. J Neurosci. 2014 Nov 12; 34(46):15288-96. PMID: 25392496.
      View in: PubMed
    5. Huang K, Maruyama T, Fan G. The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses. Cell Stem Cell. 2014 Oct 02; 15(4):410-415. PMID: 25280217.
      View in: PubMed
    6. Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Mol Syst Biol. 2014 Jul 30; 10:743. PMID: 25080494.
      View in: PubMed
    7. Huang K, Wu Z, Liu Z, Hu G, Yu J, Chang KH, Kim KP, Le T, Faull KF, Rao N, Gennery A, Xue Z, Wang CY, Pellegrini M, Fan G. Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells. Hum Mol Genet. 2014 Dec 15; 23(24):6448-57. PMID: 25027325.
      View in: PubMed
    8. Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K. PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One. 2014; 9(2):e89464. PMID: 24586797.
      View in: PubMed
    9. Huang K, Shen Y, Xue Z, Bibikova M, April C, Liu Z, Cheng L, Nagy A, Pellegrini M, Fan JB, Fan G. A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells. Stem Cell Reports. 2014 Jan 14; 2(1):36-43. PMID: 24511466.
      View in: PubMed
    10. Guo JU, Su Y, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci. 2014 Feb; 17(2):215-22. PMID: 24362762.
      View in: PubMed
    11. Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G. Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature. 2013 Aug 29; 500(7464):593-7. PMID: 23892778.
      View in: PubMed
    12. Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell. 2013 Apr 04; 12(4):470-8. PMID: 23415914.
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    13. Hu G, Huang K, Yu J, Gopalakrishna-Pillai S, Kong J, Xu H, Liu Z, Zhang K, Xu J, Luo Y, Li S, Sun YE, Iverson LE, Xue Z, Fan G. Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells. PLoS One. 2012; 7(7):e37224. PMID: 22848339.
      View in: PubMed
    14. Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacology. 2013 Jan; 38(1):23-38. PMID: 22781841.
      View in: PubMed
    15. Li J, Jiang TX, Hughes MW, Wu P, Yu J, Widelitz RB, Fan G, Chuong CM. Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol. 2012 Dec; 132(12):2681-90. PMID: 22763785.
      View in: PubMed
    16. Wu Z, Huang K, Yu J, Le T, Namihira M, Liu Y, Zhang J, Xue Z, Cheng L, Fan G. Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. J Neurosci Res. 2012 Oct; 90(10):1883-91. PMID: 22714992.
      View in: PubMed
    17. Biswas A, Liu Y, Liu T, Fan G, Tang Y. Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor. Biomaterials. 2012 Jul; 33(21):5459-67. PMID: 22521490.
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    18. Wang A, Huang K, Shen Y, Xue Z, Cai C, Horvath S, Fan G. Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells. Stem Cells Dev. 2011 Nov; 20(11):1937-50. PMID: 21542696.
      View in: PubMed
    19. Fan G, Tran J. X chromosome inactivation in human and mouse pluripotent stem cells. Hum Genet. 2011 Aug; 130(2):217-22. PMID: 21678064.
      View in: PubMed
    20. Huang K, Fan G. Epigenetic modifications in distinction: histone versus DNA methylation in ESCs. Cell Stem Cell. 2011 Jun 03; 8(6):604-5. PMID: 21624801.
      View in: PubMed
    21. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. Pancreatic ß cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29. PMID: 21497756.
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    22. Biswas A, Joo KI, Liu J, Zhao M, Fan G, Wang P, Gu Z, Tang Y. Endoprotease-mediated intracellular protein delivery using nanocapsules. ACS Nano. 2011 Feb 22; 5(2):1385-94. PMID: 21268592.
      View in: PubMed
    23. Le T, Kim KP, Fan G, Faull KF. A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples. Anal Biochem. 2011 May 15; 412(2):203-9. PMID: 21272560.
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    24. Liu B, Tahk S, Yee KM, Fan G, Shuai K. The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science. 2010 Oct 22; 330(6003):521-5. PMID: 20966256.
      View in: PubMed
    25. Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet. 2010 Nov 01; 19(21):4229-38. PMID: 20709808.
      View in: PubMed
    26. Huang K, Fan G. DNA methylation in cell differentiation and reprogramming: an emerging systematic view. Regen Med. 2010 Jul; 5(4):531-44. PMID: 20632857.
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    27. Dvash T, Lavon N, Fan G. Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells. PLoS One. 2010 Jun 25; 5(6):e11330. PMID: 20593031.
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    28. Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair. 2010 Sep; 24(7):636-44. PMID: 20424193.
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    29. Hutnick LK, Huang X, Loo TC, Ma Z, Fan G. Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism. J Biol Chem. 2010 Jul 02; 285(27):21082-91. PMID: 20404320.
      View in: PubMed
    30. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr; 13(4):423-30. PMID: 20228804.
      View in: PubMed
    31. Mason MJ, Fan G, Plath K, Zhou Q, Horvath S. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics. 2009 Jul 20; 10:327. PMID: 19619308.
      View in: PubMed
    32. Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Shi S, Wang CY. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol. 2009 Aug; 11(8):1002-9. PMID: 19578371.
      View in: PubMed
    33. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009 Aug 01; 18(15):2875-88. PMID: 19433415.
      View in: PubMed
    34. Dvash T, Fan G. Epigenetic regulation of X-inactivation in human embryonic stem cells. Epigenetics. 2009 Jan; 4(1):19-22. PMID: 19106643.
      View in: PubMed
    35. Feng J, Fan G. The role of DNA methylation in the central nervous system and neuropsychiatric disorders. Int Rev Neurobiol. 2009; 89:67-84. PMID: 19900616.
      View in: PubMed
    36. Shen Y, Fouse SD, Fan G. Genome-wide DNA methylation profiling: the mDIP-chip technology. Methods Mol Biol. 2009; 568:203-16. PMID: 19582429.
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    37. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. Copy number variant analysis of human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1484-9. PMID: 18369100.
      View in: PubMed
    38. Shen Y, Matsuno Y, Fouse SD, Rao N, Root S, Xu R, Pellegrini M, Riggs AD, Fan G. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4709-14. PMID: 18339804.
      View in: PubMed
    39. Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, Jaenisch R, Fan G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell. 2008 Feb 07; 2(2):160-9. PMID: 18371437.
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    40. Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J, Biancotti JC, Hutnick L, Krueger RC, Fan G, de Vellis J, Sun YE. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1026-31. PMID: 18195354.
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    41. Feng J, Fouse S, Fan G. Epigenetic regulation of neural gene expression and neuronal function. Pediatr Res. 2007 May; 61(5 Pt 2):58R-63R. PMID: 17413844.
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    42. Lu YC, Song J, Cho HY, Fan G, Yokoyama KK, Chiu R. Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification. J Biol Chem. 2006 Dec 22; 281(51):39081-7. PMID: 17071620.
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    43. Shen Y, Chow J, Wang Z, Fan G. Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Hum Mol Genet. 2006 Sep 01; 15(17):2623-35. PMID: 16870691.
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    44. Golshani P, Hutnick L, Schweizer F, Fan G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus Relat Syst. 2005 Sep; 3(3):227-233. PMID: 17710197.
      View in: PubMed
    45. Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 2005 Aug; 132(15):3345-56. PMID: 16014513.
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    46. He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005 May; 8(5):616-25. PMID: 15852015.
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    47. Fan G, Hutnick L. Methyl-CpG binding proteins in the nervous system. Cell Res. 2005 Apr; 15(4):255-61. PMID: 15857580.
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    48. Feng J, Chang H, Li E, Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005 Mar 15; 79(6):734-46. PMID: 15672446.
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    49. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003 Oct 31; 302(5646):890-3. PMID: 14593184.
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    50. Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res. 2002 Sep 15; 69(6):848-60. PMID: 12205678.
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