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Himburg, Heather Ann Pounds

Title(s)Associate Adjunct Professor, Medicine
SchoolMed - Hematology And Oncology
Phone68008
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    Collapse Research 
    Collapse Research Activities and Funding
    Dkk1-Endothelial Progenitor Cell Treatment for the Mitigation of Hematopoietic Radiation Injury
    NIH/NIAID U01AI138331Mar 12, 2018 - Feb 28, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP. Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. J Clin Invest. 2020 Jan 02; 130(1):315-328. PMID: 31613796.
      View in: PubMed
    2. Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP. PTPs inhibitors promote hematopoietic stem cell regeneration. Nat Commun. 2019 08 14; 10(1):3667. PMID: 31413255.
      View in: PubMed
    3. Kim MM, Schlussel L, Zhao L, Himburg HA. Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells. Radiat Res. 2019 07; 192(1):53-62. PMID: 31081743.
      View in: PubMed
    4. Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP. Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration. Cell Stem Cell. 2018 09 06; 23(3):370-381.e5. PMID: 30100167.
      View in: PubMed
    5. Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP. Wild-type Kras expands and exhausts hematopoietic stem cells. JCI Insight. 2018 06 07; 3(11). PMID: 29875320.
      View in: PubMed
    6. Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. Nat Med. 2017 01; 23(1):91-99. PMID: 27918563.
      View in: PubMed
    7. Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP. Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. Cell Rep. 2016 11 01; 17(6):1584-1594. PMID: 27806297.
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    8. Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Friedman MH. Discussion: "Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties" (Rowland, E. M., Mohamied, Y., Chooi, K. Y., Bailey, E. L., and Weinberg, P. D., 2015, ASME J. Biomech. Eng., 137(10), p. 101003): An Alternative Approach Using Segmentation Based on Local Hemodynamics. J Biomech Eng. 2016 09 01; 138(9). PMID: 27437909.
      View in: PubMed
    9. Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP. A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. Radiat Res. 2016 08; 186(2):141-52. PMID: 27387861.
      View in: PubMed
    10. Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut. 2016 Apr; 65(4):683-92. PMID: 25596181.
      View in: PubMed
    11. Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP. Protein tyrosine phosphatase-s regulates hematopoietic stem cell-repopulating capacity. J Clin Invest. 2015 Jan; 125(1):177-82. PMID: 25415437.
      View in: PubMed
    12. Lucas J, Dressman HK, Suchindran S, Nakamura M, Chao NJ, Himburg H, Minor K, Phillips G, Ross J, Abedi M, Terbrueggen R, Chute JP. A translatable predictor of human radiation exposure. PLoS One. 2014; 9(9):e107897. PMID: 25255453.
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    13. Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP. Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J Clin Invest. 2014 Nov; 124(11):4753-8. PMID: 25250571.
      View in: PubMed
    14. Chute JP, Himburg HA. Imatinib tackles lymphoma via the PDGFRß+ pericyte. Blood. 2013 Jun 27; 121(26):5107-8. PMID: 23813934.
      View in: PubMed
    15. Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med. 2013 Mar; 19(3):295-304. PMID: 23377280.
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    16. Doan PL, Russell JL, Himburg HA, Helms K, Harris JR, Lucas J, Holshausen KC, Meadows SK, Daher P, Jeffords LB, Chao NJ, Kirsch DG, Chute JP. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells. 2013 Feb; 31(2):327-37. PMID: 23132593.
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    17. Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25; 2(4):964-75. PMID: 23084748.
      View in: PubMed
    18. Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP. Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One. 2010 Jul 12; 5(7):e11535. PMID: 20634956.
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    19. LaMack JA, Himburg HA, Zhang J, Friedman MH. Endothelial gene expression in regions of defined shear exposure in the porcine iliac arteries. Ann Biomed Eng. 2010 Jul; 38(7):2252-62. PMID: 20387120.
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    20. Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010 Mar 31; 28(3):523-34. PMID: 20054864.
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    21. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr; 16(4):475-82. PMID: 20305662.
      View in: PubMed
    22. Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP. Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. Blood. 2009 Feb 26; 113(9):2104-7. PMID: 19141867.
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    23. Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Mol Endocrinol. 2009 Feb; 23(2):188-201. PMID: 19106195.
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    24. Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Ginsburg G, Chao NJ, Nevins JR, Chute JP. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 2008 Apr 02; 3(4):e1912. PMID: 18382685.
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    25. LaMack JA, Himburg HA, Friedman MH. Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aorta. Atherosclerosis. 2007 Dec; 195(2):e35-41. PMID: 17588585.
      View in: PubMed
    26. Himburg HA, Dowd SE, Friedman MH. Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H645-53. PMID: 17322417.
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    27. Himburg HA, Friedman MH. Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. J Biomech Eng. 2006 Dec; 128(6):852-6. PMID: 17154685.
      View in: PubMed
    28. Friedman MH, Himburg HA, LaMack JA. Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. J Biomech Eng. 2006 Dec; 128(6):965-8. PMID: 17154699.
      View in: PubMed
    29. Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood. 2007 Mar 15; 109(6):2365-72. PMID: 17095624.
      View in: PubMed
    30. Lamack JA, Himburg HA, Friedman MH. Effect of hypercholesterolemia on transendothelial EBD-albumin permeability and lipid accumulation in porcine iliac arteries. Atherosclerosis. 2006 Feb; 184(2):255-63. PMID: 15935354.
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    31. LaMack JA, Himburg HA, Li XM, Friedman MH. Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability. Ann Biomed Eng. 2005 Apr; 33(4):457-64. PMID: 15909651.
      View in: PubMed
    32. Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Li XM, Friedman MH. Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1916-22. PMID: 14715506.
      View in: PubMed