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Meng, Huan

Title(s)Assistant Adjunct Professor, Medicine
SchoolNanomedicine
Phone33359
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    Collapse Research 
    Collapse Research Activities and Funding
    UCLA Multifunctional Mesoporous Silica Nanoparticle Platform for Treatment of Pancreas Cancer
    NIH/NCI U01CA198846Sep 25, 2015 - Jul 31, 2020
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang Q, Lu H, Zhang L, Yan X, Zhu B, Meng H. Peri-implant mucositis sites with suppuration have higher microbial risk than sites without suppuration. J Periodontol. 2020 Feb 20. PMID: 32077493.
      View in: PubMed
    2. Yan X, Lu H, Zhang L, Zhu B, Piao M, Huang B, Zhang H, Meng H. A three-year study on periodontal microorganisms of short locking-taper implants and adjacent teeth in patients with history of periodontitis. J Dent. 2020 Feb 15; 103299. PMID: 32070755.
      View in: PubMed
    3. Li W, Zheng Q, Meng H, Chen D. Integration of genome-wide association study and expression quantitative trait loci data identifies AIM2 as a risk gene of periodontitis. J Clin Periodontol. 2020 Feb 07. PMID: 32031269.
      View in: PubMed
    4. Zhan Y, Lu R, Meng H, Hou J, Huang W, Wang X, Hu W. Platelets as inflammatory mediators in a murine model of periodontitis. J Clin Periodontol. 2020 Feb 03. PMID: 32017185.
      View in: PubMed
    5. Li W, Wang X, Tian Y, Xu L, Zhang L, Shi D, Feng X, Lu R, Meng H. A novel multi-locus genetic risk score identifies patients with higher risk of generalized aggressive periodontitis. J Periodontol. 2019 Dec 13. PMID: 31833563.
      View in: PubMed
    6. Li W, Cao X, He L, Meng H, Yang B, Liao Y. TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals. PeerJ. 2019; 7:e7828. PMID: 31772831.
      View in: PubMed
    7. Liu X, Jiang J, Meng H. Transcytosis - An effective targeting strategy that is complementary to "EPR effect" for pancreatic cancer nano drug delivery. Theranostics. 2019; 9(26):8018-8025. PMID: 31754378.
      View in: PubMed
    8. Lu H, Zhao Y, Feng X, He L, Meng H. Microbiome in maintained periodontitis and its shift over a single maintenance interval of 3 months. J Clin Periodontol. 2019 11; 46(11):1094-1104. PMID: 31376290.
      View in: PubMed
    9. Wang X, Li W, Song W, Xu L, Zhang L, Feng X, Lu R, Meng H. Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status. J Periodontal Res. 2019 Oct; 54(5):546-554. PMID: 31032950.
      View in: PubMed
    10. Liu X, Jiang J, Chan R, Ji Y, Lu J, Liao YP, Okene M, Lin J, Lin P, Chang CH, Wang X, Tang I, Zheng E, Qiu W, Wainberg ZA, Nel AE, Meng H. Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer. ACS Nano. 2019 01 22; 13(1):38-53. PMID: 30525443.
      View in: PubMed
    11. Ji Y, Liu X, Huang M, Jiang J, Liao YP, Liu Q, Chang CH, Liao H, Lu J, Wang X, Spencer MJ, Meng H. Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo. Biomaterials. 2019 02; 192:416-428. PMID: 30500723.
      View in: PubMed
    12. Jiao J, Zhang L, Meng HX, Shi D, Lu RF, Xu L, Feng XH, Cao ZQ. Clinical performance of non-surgical periodontal therapy in a large Chinese population with generalized aggressive periodontitis. J Clin Periodontol. 2018 10; 45(10):1184-1197. PMID: 29974483.
      View in: PubMed
    13. Meng H, Nel AE. Use of nano engineered approaches to overcome the stromal barrier in pancreatic cancer. Adv Drug Deliv Rev. 2018 05; 130:50-57. PMID: 29958925.
      View in: PubMed
    14. Meng H, Leong W, Leong KW, Chen C, Zhao Y. Walking the line: The fate of nanomaterials at biological barriers. Biomaterials. 2018 08; 174:41-53. PMID: 29778981.
      View in: PubMed
    15. Lu J, Liu X, Liao YP, Salazar F, Sun B, Jiang W, Chang CH, Jiang J, Wang X, Wu AM, Meng H, Nel AE. Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression. Nat Commun. 2017 11 27; 8(1):1811. PMID: 29180759.
      View in: PubMed
    16. Liu X, Jiang J, Ji Y, Lu J, Chan R, Meng H. Targeted drug delivery using iRGD peptide for solid cancer treatment. Mol Syst Des Eng. 2017 Oct 01; 2(4):370-379. PMID: 30498580.
      View in: PubMed
    17. Liu X, Jiang J, Nel AE, Meng H. Major effect of transcytosis on nano drug delivery to pancreatic cancer. Mol Cell Oncol. 2017; 4(4):e1335273. PMID: 28868347.
      View in: PubMed
    18. Jiang W, Wang X, Osborne OJ, Du Y, Chang CH, Liao YP, Sun B, Jiang J, Ji Z, Li R, Liu X, Lu J, Lin S, Meng H, Xia T, Nel AE. Pro-Inflammatory and Pro-Fibrogenic Effects of Ionic and Particulate Arsenide and Indium-Containing Semiconductor Materials in the Murine Lung. ACS Nano. 2017 02 28; 11(2):1869-1883. PMID: 28177603.
      View in: PubMed
    19. Zhan Y, Lu R, Meng H, Wang X, Sun X, Hou J. The role of platelets in inflammatory immune responses in generalized aggressive periodontitis. J Clin Periodontol. 2017 02; 44(2):150-157. PMID: 27883202.
      View in: PubMed
    20. Jiao J, Shi D, Cao ZQ, Meng HX, Lu RF, Zhang L, Song Y, Zhao JR. Effectiveness of non-surgical periodontal therapy in a large Chinese population with chronic periodontitis. J Clin Periodontol. 2017 01; 44(1):42-50. PMID: 27726174.
      View in: PubMed
    21. Mao Y, Shin KS, Wang X, Ji Z, Meng H, Chui CO. Semiconductor Electronic Label-Free Assay for Predictive Toxicology. Sci Rep. 2016 04 27; 6:24982. PMID: 27117746.
      View in: PubMed
    22. Song WL, Tian Y, Wang XE, Zhang L, Xu L, Shi D, Feng XH, Lu RF, Chen ZB, Meng HX. [Association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Feb 18; 48(1):10-5. PMID: 26885902.
      View in: PubMed
    23. Liu X, Situ A, Kang Y, Villabroza KR, Liao Y, Chang CH, Donahue T, Nel AE, Meng H. Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer. ACS Nano. 2016 Feb 23; 10(2):2702-15. PMID: 26835979.
      View in: PubMed
    24. Xu JL, Meng HX, He L, Wang XE, Zhang L. The Effects of Initial Periodontal Therapy on the Serum Receptor Activator of Nuclear Factor-?ß Ligand/Osteoprotegerin System in Patients With Type 2 Diabetes Mellitus and Periodontitis. J Periodontol. 2016 Mar; 87(3):303-11. PMID: 26561998.
      View in: PubMed
    25. Lin S, Wang X, Ji Z, Chang CH, Dong Y, Meng H, Liao YP, Wang M, Song TB, Kohan S, Xia T, Zink JI, Lin S, Nel AE. Aspect ratio plays a role in the hazard potential of CeO2 nanoparticles in mouse lung and zebrafish gastrointestinal tract. ACS Nano. 2014 May 27; 8(5):4450-64. PMID: 24720650.
      View in: PubMed
    26. Li R, Ji Z, Chang CH, Dunphy DR, Cai X, Meng H, Zhang H, Sun B, Wang X, Dong J, Lin S, Wang M, Liao YP, Brinker CJ, Nel A, Xia T. Surface interactions with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportunities for safer design. ACS Nano. 2014 Feb 25; 8(2):1771-83. PMID: 24417322.
      View in: PubMed
    27. Meng H, Zhao Y, Dong J, Xue M, Lin YS, Ji Z, Mai WX, Zhang H, Chang CH, Brinker CJ, Zink JI, Nel AE. Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice. ACS Nano. 2013 Nov 26; 7(11):10048-65. PMID: 24143858.
      View in: PubMed
    28. Wang X, Ji Z, Chang CH, Zhang H, Wang M, Liao YP, Lin S, Meng H, Li R, Sun B, Winkle LV, Pinkerton KE, Zink JI, Xia T, Nel AE. Use of coated silver nanoparticles to understand the relationship of particle dissolution and bioavailability to cell and lung toxicological potential. Small. 2014 Jan 29; 10(2):385-98. PMID: 24039004.
      View in: PubMed
    29. Wang XE, Xu L, Meng HX, Lü D, Chen ZB, Lu RF. [Long-term clinical and hematologic effects of non-surgical treatment on aggressive periodontitis]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Aug; 48(8):467-71. PMID: 24238411.
      View in: PubMed
    30. Lv D, Meng HX, Xu L, Zhang L, Chen ZB, Feng XH, Shi D, Lu RF, Wang XE. [Predictive model for post-treatment tooth loss of patients with aggressive periodontitis]. Beijing Da Xue Xue Bao Yi Xue Ban. 2013 Jun 18; 45(3):480-3. PMID: 23774932.
      View in: PubMed
    31. Zhang HD, Meng HX. [Effect of periodontal treatment on long-term prognosis of dental implants]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Apr; 48(4):229-32. PMID: 24021202.
      View in: PubMed
    32. Li R, Wang X, Ji Z, Sun B, Zhang H, Chang CH, Lin S, Meng H, Liao YP, Wang M, Li Z, Hwang AA, Song TB, Xu R, Yang Y, Zink JI, Nel AE, Xia T. Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ACS Nano. 2013 Mar 26; 7(3):2352-68. PMID: 23414138.
      View in: PubMed
    33. Meng H, Mai WX, Zhang H, Xue M, Xia T, Lin S, Wang X, Zhao Y, Ji Z, Zink JI, Nel AE. Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo. ACS Nano. 2013 Feb 26; 7(2):994-1005. PMID: 23289892.
      View in: PubMed
    34. Mai WX, Meng H. Mesoporous silica nanoparticles: A multifunctional nano therapeutic system. Integr Biol (Camb). 2013 Jan; 5(1):19-28. PMID: 23042147.
      View in: PubMed
    35. Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 2013 May 27; 9(9-10):1776-85. PMID: 23180726.
      View in: PubMed
    36. Zhang H, Dunphy DR, Jiang X, Meng H, Sun B, Tarn D, Xue M, Wang X, Lin S, Ji Z, Li R, Garcia FL, Yang J, Kirk ML, Xia T, Zink JI, Nel A, Brinker CJ. Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic. J Am Chem Soc. 2012 Sep 26; 134(38):15790-804. PMID: 22924492.
      View in: PubMed
    37. Ji Z, Wang X, Zhang H, Lin S, Meng H, Sun B, George S, Xia T, Nel AE, Zink JI. Designed synthesis of CeO2 nanorods and nanowires for studying toxicological effects of high aspect ratio nanomaterials. ACS Nano. 2012 Jun 26; 6(6):5366-80. PMID: 22564147.
      View in: PubMed
    38. Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res. 2013 Mar 19; 46(3):607-21. PMID: 22676423.
      View in: PubMed
    39. Wang X, Xia T, Duch MC, Ji Z, Zhang H, Li R, Sun B, Lin S, Meng H, Liao YP, Wang M, Song TB, Yang Y, Hersam MC, Nel AE. Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury. Nano Lett. 2012 Jun 13; 12(6):3050-61. PMID: 22546002.
      View in: PubMed
    40. Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin S, Wang X, Liao YP, Wang M, Li L, Rallo R, Damoiseaux R, Telesca D, Mädler L, Cohen Y, Zink JI, Nel AE. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano. 2012 May 22; 6(5):4349-68. PMID: 22502734.
      View in: PubMed
    41. George S, Lin S, Ji Z, Thomas CR, Li L, Mecklenburg M, Meng H, Wang X, Zhang H, Xia T, Hohman JN, Lin S, Zink JI, Weiss PS, Nel AE. Surface defects on plate-shaped silver nanoparticles contribute to its hazard potential in a fish gill cell line and zebrafish embryos. ACS Nano. 2012 May 22; 6(5):3745-59. PMID: 22482460.
      View in: PubMed
    42. Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA. Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012 May; 56(5):2535-45. PMID: 22354311.
      View in: PubMed
    43. Wang X, Xia T, Ntim SA, Ji Z, Lin S, Meng H, Chung CH, George S, Zhang H, Wang M, Li N, Yang Y, Castranova V, Mitra S, Bonner JC, Nel AE. Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung. ACS Nano. 2011 Dec 27; 5(12):9772-87. PMID: 22047207.
      View in: PubMed
    44. Meng H, Yang S, Li Z, Xia T, Chen J, Ji Z, Zhang H, Wang X, Lin S, Huang C, Zhou ZH, Zink JI, Nel AE. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS Nano. 2011 Jun 28; 5(6):4434-47. PMID: 21563770.
      View in: PubMed
    45. Meng H, Xue M, Xia T, Ji Z, Tarn DY, Zink JI, Nel AE. Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. ACS Nano. 2011 May 24; 5(5):4131-44. PMID: 21524062.
      View in: PubMed
    46. Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, Nel AE. Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells. ACS Nano. 2011 Apr 26; 5(4):2756-2769. PMID: 21366263.
      View in: PubMed
    47. Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE. Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos. ACS Nano. 2011 Feb 22; 5(2):1223-35. PMID: 21250651.
      View in: PubMed
    48. Wang X, Xia T, Ntim SA, Ji Z, George S, Meng H, Zhang H, Castranova V, Mitra S, Nel AE. Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells. ACS Nano. 2010 Dec 28; 4(12):7241-52. PMID: 21067152.
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    49. Ji Z, Jin X, George S, Xia T, Meng H, Wang X, Suarez E, Zhang H, Hoek EM, Godwin H, Nel AE, Zink JI. Dispersion and stability optimization of TiO2 nanoparticles in cell culture media. Environ Sci Technol. 2010 Oct 01; 44(19):7309-14. PMID: 20536146.
      View in: PubMed
    50. Meng H, Xue M, Xia T, Zhao YL, Tamanoi F, Stoddart JF, Zink JI, Nel AE. Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. J Am Chem Soc. 2010 Sep 15; 132(36):12690-7. PMID: 20718462.
      View in: PubMed
    51. Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI, Nel AE. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano. 2010 Aug 24; 4(8):4539-50. PMID: 20731437.
      View in: PubMed
    52. Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano. 2009 Oct 27; 3(10):3273-86. PMID: 19739605.
      View in: PubMed
    53. Meng H, Xia T, George S, Nel AE. A predictive toxicological paradigm for the safety assessment of nanomaterials. ACS Nano. 2009 Jul 28; 3(7):1620-7. PMID: 21452863.
      View in: PubMed
    54. Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis AJ. Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4530-5. PMID: 17360558.
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