Irvin Sy Chen

Title(s)Professor, MIMG
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    Title(s)Professor, Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    (Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
    NIH U19AI149504May 7, 2020 - Apr 30, 2025
    Role: Co-Principal Investigator
    In Vivo Gene Editing for HIV-1 Cure
    NIH R01AI145038Feb 11, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Anti-HIV Gene Therapy: Defend and Attack
    NIH U19AI117941May 1, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Mouse and mathematical models for HIV-1 suppression through HSPC
    NIH R56HL126544Sep 6, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Survival of the fittest HSPC repopulating clones by anti-HIV-1 gene-modification
    NIH R01HL125030Aug 15, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Gene engineering using CRISPR/Cas9 mutagenesis to eliminate latent HIV-1
    NIH R21AI114433Aug 1, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Hematopoietic stem/progenitor cell reservoirs
    NIH R01AI110297Nov 20, 2013 - Oct 31, 2019
    Role: Principal Investigator
    Molecular Imaging of Cancer In vivo via Targeted Transduction
    NIH R01CA120327Apr 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    Targeting Gene Delivery to the CNS Blood-Brain Barrier
    NIH R21NS055212Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Retargeting of Retroviral Vectors
    NIH R01AI069350Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Interdisciplinary Training in Virology and Gene Therapy
    NIH T32AI060567Sep 1, 2004 - Aug 31, 2020
    Role: Co-Principal Investigator
    Modeling HIV-1 SiRNA Therapy
    NIH R01AI055281Mar 1, 2003 - Apr 30, 2012
    Role: Principal Investigator
    NIH R21AI042687Sep 30, 1999 - Sep 29, 2002
    Role: Principal Investigator
    Structure/Function of HIV-1 Vpr Associated Cell Proteins
    NIH R01AI043190Apr 1, 1998 - May 31, 2007
    Role: Principal Investigator
    NIH R01AI039975Apr 1, 1997 - Nov 30, 2006
    Role: Principal Investigator
    NIH R13AI040201Jul 1, 1996 - Jun 30, 1997
    Role: Principal Investigator
    HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    NIH R01CA070018Jul 18, 1995 - Apr 30, 2009
    Role: Principal Investigator
    NIH R01DK054912Aug 1, 1994 - Apr 30, 2002
    Role: Principal Investigator
    NIH R01AI036555Aug 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    NIH R01AI031822Feb 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    NIH R01CA054551May 1, 1991 - Apr 30, 1994
    Role: Principal Investigator
    NIH R01AI029107Sep 30, 1989 - Jul 31, 1994
    Role: Principal Investigator
    NIH R01NS025508May 1, 1988 - Apr 30, 1993
    Role: Principal Investigator
    NIH R37CA038597Jan 1, 1985 - Dec 31, 1996
    Role: Principal Investigator
    NIH R01CA038597Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator
    UCLA Center for AIDS Research (CFAR)
    NIH P30AI028697Feb 29, 2020
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias. Stem Cell Res Ther. 2021 10 07; 12(1):528. Suryawanshi GW, Arokium H, Kim S, Khamaikawin W, Lin S, Shimizu S, Chupradit K, Lee Y, Xie Y, Guan X, Suryawanshi V, Presson AP, An DS, Chen ISY. PMID: 34620229; PMCID: PMC8499514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques. PLoS Pathog. 2021 07; 17(7):e1009738. Wen J, Cheever T, Wang L, Wu D, Reed J, Mascola J, Chen X, Liu C, Pegu A, Sacha JB, Lu Y, Haigwood NL, Chen ISY. PMID: 34283885; PMCID: PMC8323878.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 04; 17(4):e1009404. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 33793675; PMCID: PMC8016106.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model. J Immunother Cancer. 2021 02; 9(2). Wen J, Wang L, Ren J, Kranz E, Chen S, Wu D, Kanazawa T, Chen I, Lu Y, Kamata M. PMID: 33593826; PMCID: PMC7888328.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques. JCI Insight. 2021 01 11; 6(1). Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. PMID: 33427210; PMCID: PMC7821595.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. The clonal repopulation of HSPC gene modified with anti-HIV-1 RNAi is not affected by preexisting HIV-1 infection. Sci Adv. 2020 07; 6(30):eaay9206. Suryawanshi GW, Khamaikawin W, Wen J, Shimizu S, Arokium H, Xie Y, Wang E, Kim S, Choi H, Zhang C, Yu H, Presson AP, Kim N, An DS, Chen ISY, Kim S. PMID: 32766447; PMCID: PMC7385479.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates. Front Immunol. 2019; 10:3132. Qin M, Wang L, Wu D, Williams CK, Xu D, Kranz E, Guo Q, Guan J, Vinters HV, Lee Y, Xie Y, Luo Y, Sun G, Sun X, He Z, Lu Y, Kamata M, Wen J, Chen ISY. PMID: 32047498; PMCID: PMC6996053.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    8. Real-Time Quantification of Cell Internalization Kinetics by Functionalized Bioluminescent Nanoprobes. Adv Mater. 2019 Sep; 31(39):e1902469. Wu D, Yang Y, Xu P, Xu D, Liu Y, Castillo R, Yan R, Ren J, Zhou G, Liu C, Qin M, Du J, Hou L, Chen I, Kang C, Jin L, Wen J, Chen W, Lu Y. PMID: 31402525.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice. Nat Biomed Eng. 2019 09; 3(9):706-716. Wen J, Wu D, Qin M, Liu C, Wang L, Xu D, Vinters HV, Liu Y, Kranz E, Guan X, Sun G, Sun X, Lee Y, Martinez-Maza O, Widney D, Lu Y, Chen ISY, Kamata M. PMID: 31384008; PMCID: PMC6736720.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    10. Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration. Adv Mater. 2019 Aug; 31(33):e1900727. Xu D, Wu D, Qin M, Nih LR, Liu C, Cao Z, Ren J, Chen X, He Z, Yu W, Guan J, Duan S, Liu F, Liu X, Li J, Harley D, Xu B, Hou L, Chen ISY, Wen J, Chen W, Pourtaheri S, Lu Y. PMID: 31125138.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    11. A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System. Adv Mater. 2019 May; 31(18):e1807557. Wu D, Qin M, Xu D, Wang L, Liu C, Ren J, Zhou G, Chen C, Yang F, Li Y, Zhao Y, Huang R, Pourtaheri S, Kang C, Kamata M, Chen ISY, He Z, Wen J, Chen W, Lu Y. PMID: 30803073; PMCID: PMC6701476.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    12. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2017 12; 13(12):e1006753. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. PMID: 29284044; PMCID: PMC5746250.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    13. Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:23-32. Khamaikawin W, Shimizu S, Kamata M, Cortado R, Jung Y, Lam J, Wen J, Kim P, Xie Y, Kim S, Arokium H, Presson AP, Chen ISY, An DS. PMID: 29322065; PMCID: PMC5751878.
      View in: PubMed   Mentions: 7  
    14. Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S59-S69. Chan J, Kim PY, Kranz E, Nagaoka Y, Lee Y, Wen J, Elsaesser HJ, Qin M, Brooks DG, Ringpis GE, Chen ISY, Kamata M. PMID: 29140111; PMCID: PMC5684681.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow. J Vis Exp. 2017 06 14; (124). Suryawanshi GW, Xu S, Xie Y, Chou T, Kim N, Chen ISY, Kim S. PMID: 28654067; PMCID: PMC5608418.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies. J Virol. 2016 08 01; 90(15):6999-7006. Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO. PMID: 27226366; PMCID: PMC4944295.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    17. Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules. PLoS One. 2016; 11(4):e0151572. Wen J, Yan M, Liu Y, Li J, Xie Y, Lu Y, Kamata M, Chen IS. PMID: 27049645; PMCID: PMC4822841.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. PMID: 26050990; PMCID: PMC4817874.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    19. Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs. PLoS One. 2015; 10(6):e0127986. Yan M, Wen J, Liang M, Lu Y, Kamata M, Chen IS. PMID: 26035832; PMCID: PMC4452785.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation. Biochem Biophys Res Commun. 2015 Jul 31; 463(3):216-21. Kamata M, Kim PY, Ng HL, Ringpis GE, Kranz E, Chan J, O'Connor S, Yang OO, Chen IS. PMID: 25998390; PMCID: PMC4686265.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice. Mol Ther Nucleic Acids. 2015 Feb 17; 4:e227. Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen IS, An DS. PMID: 25689223; PMCID: PMC4345313.
      View in: PubMed   Mentions: 18  
    22. Deep sequencing reveals low incidence of endogenous LINE-1 retrotransposition in human induced pluripotent stem cells. PLoS One. 2014; 9(10):e108682. Arokium H, Kamata M, Kim S, Kim N, Liang M, Presson AP, Chen IS. PMID: 25289675; PMCID: PMC4188539.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. High-throughput screening of effective siRNAs using luciferase-linked chimeric mRNA. PLoS One. 2014; 9(5):e96445. Pang S, Pokomo L, Chen K, Kamata M, Mao SH, Zhang H, Razi E, An DS, Chen IS. PMID: 24831610; PMCID: PMC4022502.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell Stem Cell. 2014 Apr 03; 14(4):473-85. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. PMID: 24702996; PMCID: PMC4009343.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    25. Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor. Mol Ther Methods Clin Dev. 2014; 1:11. Wolstein O, Boyd M, Millington M, Impey H, Boyer J, Howe A, Delebecque F, Cornetta K, Rothe M, Baum C, Nicolson T, Koldej R, Zhang J, Keech N, Camba Colón J, Breton L, Bartlett J, An DS, Chen IS, Burke B, Symonds GP. PMID: 26015947; PMCID: PMC4365823.
      View in: PubMed   Mentions: 29  
    26. Role of phosphatidylserine receptors in enveloped virus infection. J Virol. 2014 Apr; 88(8):4275-90. Morizono K, Chen IS. PMID: 24478428; PMCID: PMC3993771.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    27. Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. J Gene Med. 2014 Jan-Feb; 16(1-2):11-27. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. PMID: 24436117; PMCID: PMC4051223.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Retargeting vesicular stomatitis virus glycoprotein pseudotyped lentiviral vectors with enhanced stability by in situ synthesized polymer shell. Hum Gene Ther Methods. 2013 Feb; 24(1):11-8. Liang M, Yan M, Lu Y, Chen IS. PMID: 23327104; PMCID: PMC4275776.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    29. Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice. PLoS One. 2012; 7(12):e53492. Ringpis GE, Shimizu S, Arokium H, Camba-Col?n J, Carroll MV, Cortado R, Xie Y, Kim PY, Sahakyan A, Lowe EL, Narukawa M, Kandarian FN, Burke BP, Symonds GP, An DS, Chen IS, Kamata M. PMID: 23300932; PMCID: PMC3534037.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    30. Single siRNA nanocapsules for enhanced RNAi delivery. J Am Chem Soc. 2012 Aug 22; 134(33):13542-5. Yan M, Liang M, Wen J, Liu Y, Lu Y, Chen IS. PMID: 22866878; PMCID: PMC4318836.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    31. Methodology and software to detect viral integration site hot-spots. BMC Bioinformatics. 2011 Sep 14; 12:367. Presson AP, Kim N, Xiaofei Y, Chen IS, Kim S. PMID: 21914224; PMCID: PMC3203353.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Receptors and tropisms of envelope viruses. Curr Opin Virol. 2011 Jul; 1(1):13-8. Morizono K, Chen IS. PMID: 21804908; PMCID: PMC3144558.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    33. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe. 2011 Apr 21; 9(4):286-98. Morizono K, Xie Y, Olafsen T, Lee B, Dasgupta A, Wu AM, Chen IS. PMID: 21501828; PMCID: PMC3095825.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    34. Introduction. The UCLA AIDS Institute. Immunol Res. 2010 Dec; 48(1-3):1-2. Chen IS. PMID: 20703827.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    35. Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter. Hum Gene Ther. 2010 Nov; 21(11):1555-67. Kamata M, Liu S, Liang M, Nagaoka Y, Chen IS. PMID: 20524893; PMCID: PMC2978547.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    36. High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones. J Virol. 2010 Nov; 84(22):11771-80. Kim S, Kim N, Presson AP, An DS, Mao SH, Bonifacino AC, Donahue RE, Chow SA, Chen IS. PMID: 20844053; PMCID: PMC2977897.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs. PLoS One. 2010 Jul 28; 5(7):e11834. Kamata M, Liang M, Liu S, Nagaoka Y, Chen IS. PMID: 20676373; PMCID: PMC2911382.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    38. Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins. J Virol. 2010 Jul; 84(14):6923-34. Morizono K, Ku A, Xie Y, Harui A, Kung SK, Roth MD, Lee B, Chen IS. PMID: 20484510; PMCID: PMC2898243.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    39. Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction. J Gene Med. 2010 Mar; 12(3):255-65. Liang M, Kamata M, Chen KN, Pariente N, An DS, Chen IS. PMID: 20186995; PMCID: PMC4340654.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    40. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 2010 Feb 25; 115(8):1534-44. Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS. PMID: 20018916; PMCID: PMC2830759.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    41. Targeted transduction via CD4 by a lentiviral vector uses a clathrin-mediated entry pathway. J Virol. 2009 Dec; 83(24):13026-31. Liang M, Morizono K, Pariente N, Kamata M, Lee B, Chen IS. PMID: 19793825; PMCID: PMC2786851.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells. J Virol. 2009 Nov; 83(21):11283-97. Arokium H, Kamata M, Chen I. PMID: 19692467; PMCID: PMC2772804.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    43. A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide. J Gene Med. 2009 Aug; 11(8):655-63. Morizono K, Xie Y, Helguera G, Daniels TR, Lane TF, Penichet ML, Chen IS. PMID: 19455593; PMCID: PMC2834590.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    44. Redirecting lentiviral vectors by insertion of integrin-tageting peptides into envelope proteins. J Gene Med. 2009 Jul; 11(7):549-58. Morizono K, Pariente N, Xie Y, Chen IS. PMID: 19434609; PMCID: PMC2834586.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    45. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther. 2009 Jun 10; 7:8. Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, Boyer J, Qin FX, An DS, Chen IS. PMID: 19515239; PMCID: PMC2701936.
      View in: PubMed   Mentions: 28  
    46. Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells. PLoS Pathog. 2009 Mar; 5(3):e1000342. Kamata M, Nagaoka Y, Chen IS. PMID: 19300495; PMCID: PMC2652112.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    47. Targeted transduction of CD34+ hematopoietic progenitor cells in nonpurified human mobilized peripheral blood mononuclear cells. J Gene Med. 2009 Mar; 11(3):185-96. Liang M, Pariente N, Morizono K, Chen IS. PMID: 19152374; PMCID: PMC3775470.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    48. Enhanced transthyretin tetramer stability following expression of an amyloid disease transsuppressor variant in mammalian cells. J Gene Med. 2009 Feb; 11(2):103-11. Kamata M, Susanto MT, Chen IS. PMID: 19065606; PMCID: PMC6589401.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    49. Regulation of prostate-specific antigen expression by the junctional adhesion molecule A. Urology. 2009 May; 73(5):1119-25. Wang Q, Zheng JY, Kreth J, Yan X, Kamata M, Campbell RA, Xie Y, Chiu R, Berenson JR, Shi W, Chen IS, Pang S. PMID: 18602143.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2. J Virol. 2008 Jun; 82(12):5672-82. Kamata M, Watanabe N, Nagaoka Y, Chen IS. PMID: 18385244; PMCID: PMC2395134.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    51. Efficient targeted transduction of primary human endothelial cells with dual-targeted lentiviral vectors. J Gene Med. 2008 Mar; 10(3):242-8. Pariente N, Mao SH, Morizono K, Chen IS. PMID: 18074400.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    52. Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int J Cancer. 2007 Nov 15; 121(10):2153-61. Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. PMID: 17583576; PMCID: PMC2838420.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    53. Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13110-5. An DS, Donahue RE, Kamata M, Poon B, Metzger M, Mao SH, Bonifacino A, Krouse AE, Darlix JL, Baltimore D, Qin FX, Chen IS. PMID: 17670939; PMCID: PMC1941789.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    54. Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. J Virol. 2007 Oct; 81(19):10515-23. Poon B, Chang MA, Chen IS. PMID: 17652391; PMCID: PMC2045493.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    55. A novel dual-targeted lentiviral vector leads to specific transduction of prostate cancer bone metastases in vivo after systemic administration. Mol Ther. 2007 Nov; 15(11):1973-81. Pariente N, Morizono K, Virk MS, Petrigliano FA, Reiter RE, Lieberman JR, Chen IS. PMID: 17653099.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    56. Paradoxical effects of two theta-defensins on HIV type 1 infection. AIDS Res Hum Retroviruses. 2007 Apr; 23(4):508-14. Wang Q, Wang W, Zheng J, Tabibian S, Xie Y, Song J, Waring AJ, Chiu R, Yang OO, Chen IS, Lehrer RI, Pang S. PMID: 17506607.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    57. Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection. Clin Vaccine Immunol. 2007 Apr; 14(4):391-6. An DS, Poon B, Ho Tsong Fang R, Weijer K, Blom B, Spits H, Chen IS, Uittenbogaart CH. PMID: 17314230; PMCID: PMC1865603.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    58. gp120-independent HIV infection of cells derived from the female reproductive tract, brain, and colon. J Acquir Immune Defic Syndr. 2006 Oct 01; 43(2):127-36. Zheng J, Xie Y, Campbell R, Song J, Wang RQ, Chiu R, Berenson J, Razi M, Massachi S, Yang OO, Chen IS, Pang S. PMID: 16951651.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    59. Transient low pH treatment enhances infection of lentiviral vector pseudotypes with a targeting Sindbis envelope. Virology. 2006 Nov 10; 355(1):71-81. Morizono K, Ringpis GE, Pariente N, Xie Y, Chen IS. PMID: 16905172.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    60. Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):1101-6. Kamata M, Wu RP, An DS, Saxe JP, Damoiseaux R, Phelps ME, Huang J, Chen IS. PMID: 16904642; PMCID: PMC1761125.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    61. In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models. J Orthop Res. 2006 Aug; 24(8):1709-21. Feeley BT, Conduah AH, Sugiyama O, Krenek L, Chen IS, Lieberman JR. PMID: 16788987.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    62. Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther. 2006 Oct; 14(4):494-504. An DS, Qin FX, Auyeung VC, Mao SH, Kung SK, Baltimore D, Chen IS. PMID: 16844419; PMCID: PMC2562632.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    63. Involvement of claudin-7 in HIV infection of CD4(-) cells. Retrovirology. 2005 Dec 20; 2:79. Zheng J, Xie Y, Campbell R, Song J, Massachi S, Razi M, Chiu R, Berenson J, Yang OO, Chen IS, Pang S. PMID: 16368003; PMCID: PMC1352390.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    64. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005 Oct; 3(4):377-92. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. PMID: 16250884.
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    65. Targeted gene delivery by intravenous injection of retroviral vectors. Cell Cycle. 2005 Jul; 4(7):854-6. Morizono K, Chen IS. PMID: 15970695.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    66. Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model. Hum Gene Ther. 2005 Apr; 16(4):527-32. Kung SK, Bonifacino A, Metzger ME, Ringpis GE, Donahue RE, Chen IS. PMID: 15871684.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    67. Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo. Mol Ther. 2005 Mar; 11(3):390-8. Sugiyama O, An DS, Kung SP, Feeley BT, Gamradt S, Liu NQ, Chen IS, Lieberman JR. PMID: 15727935.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    68. Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat Med. 2005 Mar; 11(3):346-52. Morizono K, Xie Y, Ringpis GE, Johnson M, Nassanian H, Lee B, Wu L, Chen IS. PMID: 15711560.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    69. Ethanol stimulation of HIV infection of oral epithelial cells. J Acquir Immune Defic Syndr. 2004 Dec 01; 37(4):1445-53. Zheng J, Yang OO, Xie Y, Campbell R, Chen IS, Pang S. PMID: 15602121.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    70. Increased levels of Wee-1 kinase in G(2) are necessary for Vpr- and gamma irradiation-induced G(2) arrest. J Virol. 2004 Aug; 78(15):8183-90. Yuan H, Kamata M, Xie YM, Chen IS. PMID: 15254189; PMCID: PMC446131.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    71. Inhibition of influenza virus matrix (M1) protein expression and virus replication by U6 promoter-driven and lentivirus-mediated delivery of siRNA. J Gen Virol. 2004 Jul; 85(Pt 7):1877-1884. Hui EK, Yap EM, An DS, Chen ISY, Nayak DP. PMID: 15218172.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    72. Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells. Mol Ther. 2003 Dec; 8(6):981-91. Kung SK, An DS, Bonifacino A, Metzger ME, Ringpis GE, Mao SH, Chen IS, Donahue RE. PMID: 14664801.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    73. Efficient lentiviral vectors for short hairpin RNA delivery into human cells. Hum Gene Ther. 2003 Aug 10; 14(12):1207-12. An DS, Xie Y, Mao SH, Morizono K, Kung SK, Chen IS. PMID: 12908971.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    74. Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol. 2003 Apr; 77(7):3962-72. Poon B, Chen IS. PMID: 12634356; PMCID: PMC150668.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    75. Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis. J Virol. 2003 Feb; 77(3):2063-70. Yuan H, Xie YM, Chen IS. PMID: 12525641; PMCID: PMC140938.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    76. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003; 174(3):101-9. De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH. PMID: 12835573.
      View in: PubMed   Mentions: 344     Fields:    Translation:HumansCells
    77. Multilineage cells from adipose tissue as gene delivery vehicles. Hum Gene Ther. 2003 Jan 01; 14(1):59-66. Morizono K, De Ugarte DA, Zhu M, Zuk P, Elbarbary A, Ashjian P, Benhaim P, Chen IS, Hedrick MH. PMID: 12573059.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    78. gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1. J Acquir Immune Defic Syndr. 2002 May 01; 30(1):1-8. Chow YH, Yu D, Zhang JY, Xie Y, Wei OL, Chiu C, Foroohar M, Yang OO, Park NH, Chen IS, Pang S. PMID: 12048357.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    79. Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. J Virol. 2002 Feb; 76(4):1626-31. Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BD. PMID: 11799157; PMCID: PMC135916.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
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