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Chen, Irvin Sy

Title(s)Professor, Mimg
Phone54793
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
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    In Vivo Gene Editing for HIV-1 Cure
    NIH/NIAID R01AI145038Feb 11, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Anti-HIV Gene Therapy: Defend and Attack
    NIH/NIAID U19AI117941May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Mouse and mathematical models for HIV-1 suppression through HSPC
    NIH/NHLBI R56HL126544Sep 6, 2014 - Aug 31, 2015
    Role: Principal Investigator
    Survival of the fittest HSPC repopulating clones by anti-HIV-1 gene-modification
    NIH/NHLBI R01HL125030Aug 15, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Gene engineering using CRISPR/Cas9 mutagenesis to eliminate latent HIV-1
    NIH/NIAID R21AI114433Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Hematopoietic stem/progenitor cell reservoirs
    NIH/NIAID R01AI110297Nov 20, 2013 - Oct 31, 2018
    Role: Principal Investigator
    Molecular Imaging of Cancer In vivo via Targeted Transduction
    NIH/NCI R01CA120327Apr 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    Targeting Gene Delivery to the CNS Blood-Brain Barrier
    NIH/NINDS R21NS055212Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Retargeting of Retroviral Vectors
    NIH/NIAID R01AI069350Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Interdisciplinary Training in Virology and Gene Therapy
    NIH/NIAID T32AI060567Sep 1, 2004 - Aug 31, 2019
    Role: Co-Principal Investigator
    Modeling HIV-1 SiRNA Therapy
    NIH/NIAID R01AI055281Mar 1, 2003 - Feb 28, 2009
    Role: Principal Investigator
    A RATIONAL APPROACH TO DEVELOPING A KILLED HIV-1 VACCINE
    NIH/NIAID R21AI042687Sep 30, 1999 - Sep 29, 2002
    Role: Principal Investigator
    Structure/Function of HIV-1 Vpr Associated Cell Proteins
    NIH/NIAID R01AI043190Apr 1, 1998 - Sep 29, 2001
    Role: Principal Investigator
    PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    NIH/NIAID R01AI039975Apr 1, 1997 - Nov 30, 2006
    Role: Principal Investigator
    HUMAN GENE THERAPY FOR HIV INFECTION--HOPES AND HURDLES
    NIH/NIAID R13AI040201Jul 1, 1996 - Jun 30, 1997
    Role: Principal Investigator
    HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    NIH/NCI R01CA070018Jul 18, 1995 - Jun 30, 2008
    Role: Principal Investigator
    MODELLING GENE THERAPEUTICS APPROACHES IN SCID-HU MICE
    NIH/NIDDK R01DK054912Aug 1, 1994 - Apr 30, 2002
    Role: Principal Investigator
    MODELLING GENE THERAPEUTIC APPROACHES IN SCID/HU MICE
    NIH/NIAID R01AI036555Aug 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    RESTRICTED INFECTION OF CD4+ CELLS BY HIV-1
    NIH/NIAID R01AI031822Feb 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    HTLV PATHOGENESIS IN VIVO
    NIH/NCI R01CA054551May 1, 1991 - Apr 30, 1994
    Role: Principal Investigator
    PRIMARY CELL SYSTEMS FOR THE STUDY OF HIV-I LATENCY
    NIH/NIAID R01AI029107Sep 30, 1989 - Jul 31, 1994
    Role: Principal Investigator
    MOLECULAR VIROLOGICAL STUDIES OF AIDS CNS DISORDERS
    NIH/NINDS R01NS025508May 1, 1988 - Apr 30, 1993
    Role: Principal Investigator
    MOLECULAR GENETIC STUDY OF HUMAN T-CELL LEUKEMIA VIRUS
    NIH/NCI R37CA038597Jan 1, 1985 - Dec 31, 1996
    Role: Principal Investigator
    A MOLECULAR GENETIC STUDY OF HUMAN T-CELL LEUKEMIA VIRUS
    NIH/NCI R01CA038597Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator
    UCLA Center for AIDS Research (CFAR)
    NIH/NIAID P30AI028697May 31, 2012
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. PMID: 26050990.
      View in: PubMed
    2. Presson AP, Kim N, Xiaofei Y, Chen IS, Kim S. Methodology and software to detect viral integration site hot-spots. BMC Bioinformatics. 2011 Sep 14; 12:367. PMID: 21914224.
      View in: PubMed
    3. Chen IS. Introduction. The UCLA AIDS Institute. Immunol Res. 2010 Dec; 48(1-3):1-2. PMID: 20703827.
      View in: PubMed
    4. Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, Boyer J, Qin FX, An DS, Chen IS. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther. 2009 Jun 10; 7:8. PMID: 19515239.
      View in: PubMed
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