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Irvin Sy Chen

Title(s)Professor, MIMG
SchoolMedicine
Address609 Charles E. Young Drive, Ea 1602A
Los Angeles CA 90024
Phone54793
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    (Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
    NIH U19AI149504May 7, 2020 - Apr 30, 2025
    Role: Co-Principal Investigator
    In Vivo Gene Editing for HIV-1 Cure
    NIH R01AI145038Feb 11, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Anti-HIV Gene Therapy: Defend and Attack
    NIH U19AI117941May 1, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Mouse and mathematical models for HIV-1 suppression through HSPC
    NIH R56HL126544Sep 6, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Survival of the fittest HSPC repopulating clones by anti-HIV-1 gene-modification
    NIH R01HL125030Aug 15, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Gene engineering using CRISPR/Cas9 mutagenesis to eliminate latent HIV-1
    NIH R21AI114433Aug 1, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Hematopoietic stem/progenitor cell reservoirs
    NIH R01AI110297Nov 20, 2013 - Oct 31, 2019
    Role: Principal Investigator
    Molecular Imaging of Cancer In vivo via Targeted Transduction
    NIH R01CA120327Apr 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    Targeting Gene Delivery to the CNS Blood-Brain Barrier
    NIH R21NS055212Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Retargeting of Retroviral Vectors
    NIH R01AI069350Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Interdisciplinary Training in Virology and Gene Therapy
    NIH T32AI060567Sep 1, 2004 - Aug 31, 2020
    Role: Co-Principal Investigator
    Modeling HIV-1 SiRNA Therapy
    NIH R01AI055281Mar 1, 2003 - Apr 30, 2012
    Role: Principal Investigator
    A RATIONAL APPROACH TO DEVELOPING A KILLED HIV-1 VACCINE
    NIH R21AI042687Sep 30, 1999 - Sep 29, 2002
    Role: Principal Investigator
    Structure/Function of HIV-1 Vpr Associated Cell Proteins
    NIH R01AI043190Apr 1, 1998 - Sep 29, 2001
    Role: Principal Investigator
    PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    NIH R01AI039975Apr 1, 1997 - Dec 14, 2000
    Role: Principal Investigator
    HUMAN GENE THERAPY FOR HIV INFECTION--HOPES AND HURDLES
    NIH R13AI040201Jul 1, 1996 - Jun 30, 1997
    Role: Principal Investigator
    HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    NIH R01CA070018Jul 18, 1995 - Jul 16, 1998
    Role: Principal Investigator
    MODELLING GENE THERAPEUTICS APPROACHES IN SCID-HU MICE
    NIH R01DK054912Aug 1, 1994 - Apr 30, 2002
    Role: Principal Investigator
    MODELLING GENE THERAPEUTIC APPROACHES IN SCID/HU MICE
    NIH R01AI036555Aug 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    RESTRICTED INFECTION OF CD4+ CELLS BY HIV-1
    NIH R01AI031822Feb 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    HTLV PATHOGENESIS IN VIVO
    NIH R01CA054551May 1, 1991 - Apr 30, 1994
    Role: Principal Investigator
    PRIMARY CELL SYSTEMS FOR THE STUDY OF HIV-I LATENCY
    NIH R01AI029107Sep 30, 1989 - Jul 31, 1994
    Role: Principal Investigator
    MOLECULAR VIROLOGICAL STUDIES OF AIDS CNS DISORDERS
    NIH R01NS025508May 1, 1988 - Apr 30, 1993
    Role: Principal Investigator
    MOLECULAR GENETIC STUDY OF HUMAN T-CELL LEUKEMIA VIRUS
    NIH R37CA038597Jan 1, 1985 - Dec 31, 1996
    Role: Principal Investigator
    A MOLECULAR GENETIC STUDY OF HUMAN T-CELL LEUKEMIA VIRUS
    NIH R01CA038597Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator
    UCLA Center for AIDS Research (CFAR)
    NIH P30AI028697Dec 31, 2007
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. PMID: 26050990.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    2. Methodology and software to detect viral integration site hot-spots. BMC Bioinformatics. 2011 Sep 14; 12:367. Presson AP, Kim N, Xiaofei Y, Chen IS, Kim S. PMID: 21914224.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    3. Introduction. The UCLA AIDS Institute. Immunol Res. 2010 Dec; 48(1-3):1-2. Chen IS. PMID: 20703827.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther. 2009 Jun 10; 7:8. Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, Boyer J, Qin FX, An DS, Chen IS. PMID: 19515239.
      View in: PubMed   Mentions:
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