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Chen Irvin

Title(s)Professor, Microbiology Immunology & Molecular Genetics
Phone310-825-4793
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    Collapse Research 
    Collapse Research Activities and Funding
    In Vivo Gene Editing for HIV-1 Cure
    NIH/NIAID R01AI145038Feb 11, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Anti-HIV Gene Therapy: Defend and Attack
    NIH/NIAID U19AI117941May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Mouse and mathematical models for HIV-1 suppression through HSPC
    NIH/NHLBI R56HL126544Sep 6, 2014 - Aug 31, 2015
    Role: Principal Investigator
    Survival of the fittest HSPC repopulating clones by anti-HIV-1 gene-modification
    NIH/NHLBI R01HL125030Aug 15, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Gene engineering using CRISPR/Cas9 mutagenesis to eliminate latent HIV-1
    NIH/NIAID R21AI114433Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Hematopoietic stem/progenitor cell reservoirs
    NIH/NIAID R01AI110297Nov 20, 2013 - Oct 31, 2018
    Role: Principal Investigator
    Molecular Imaging of Cancer In vivo via Targeted Transduction
    NIH/NCI R01CA120327Apr 1, 2007 - Jan 31, 2010
    Role: Principal Investigator
    Targeting Gene Delivery to the CNS Blood-Brain Barrier
    NIH/NINDS R21NS055212Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Retargeting of Retroviral Vectors
    NIH/NIAID R01AI069350Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Interdisciplinary Training in Virology and Gene Therapy
    NIH/NIAID T32AI060567Sep 1, 2004 - Aug 31, 2019
    Role: Co-Principal Investigator
    Modeling HIV-1 SiRNA Therapy
    NIH/NIAID R01AI055281Mar 1, 2003 - Apr 30, 2012
    Role: Principal Investigator
    A RATIONAL APPROACH TO DEVELOPING A KILLED HIV-1 VACCINE
    NIH/NIAID R21AI042687Sep 30, 1999 - Sep 29, 2002
    Role: Principal Investigator
    Structure/Function of HIV-1 Vpr Associated Cell Proteins
    NIH/NIAID R01AI043190Apr 1, 1998 - May 31, 2007
    Role: Principal Investigator
    PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    NIH/NIAID R01AI039975Apr 1, 1997 - Nov 30, 2006
    Role: Principal Investigator
    HUMAN GENE THERAPY FOR HIV INFECTION--HOPES AND HURDLES
    NIH/NIAID R13AI040201Jul 1, 1996 - Jun 30, 1997
    Role: Principal Investigator
    HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    NIH/NCI R01CA070018Jul 18, 1995 - Apr 30, 2009
    Role: Principal Investigator
    MODELLING GENE THERAPEUTICS APPROACHES IN SCID-HU MICE
    NIH/NIDDK R01DK054912Aug 1, 1994 - Apr 30, 2002
    Role: Principal Investigator
    MODELLING GENE THERAPEUTIC APPROACHES IN SCID/HU MICE
    NIH/NIAID R01AI036555Aug 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    RESTRICTED INFECTION OF CD4+ CELLS BY HIV-1
    NIH/NIAID R01AI031822Feb 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    UCLA Center for AIDS Research (CFAR)
    NIH/NIAID P30AI028697Sep 1, 1991 - Feb 28, 2019
    Role: Co-Principal Investigator
    HTLV PATHOGENESIS IN VIVO
    NIH/NCI R01CA054551May 1, 1991 - Apr 30, 1994
    Role: Principal Investigator
    PRIMARY CELL SYSTEMS FOR THE STUDY OF HIV-I LATENCY
    NIH/NIAID R01AI029107Sep 30, 1989 - Jul 31, 1994
    Role: Principal Investigator
    MOLECULAR VIROLOGICAL STUDIES OF AIDS CNS DISORDERS
    NIH/NINDS R01NS025508May 1, 1988 - Apr 30, 1993
    Role: Principal Investigator
    MOLECULAR GENETIC STUDY OF HUMAN T-CELL LEUKEMIA VIRUS
    NIH/NCI R37CA038597Jan 1, 1985 - Dec 31, 1996
    Role: Principal Investigator
    A MOLECULAR GENETIC STUDY OF HUMAN T-CELL LEUKEMIA VIRUS
    NIH/NCI R01CA038597Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang H, Qin M, Liu R, Ding X, Chen ISY, Jiang Y. Characterization of A Bifunctional Synthetic RNA Aptamer and A Truncated Form for Ability to Inhibit Growth of Non-Small Cell Lung Cancer. Sci Rep. 2019 Dec 11; 9(1):18836. PMID: 31827170.
      View in: PubMed
    2. Wu D, Yang Y, Xu P, Xu D, Liu Y, Castillo R, Yan R, Ren J, Zhou G, Liu C, Qin M, Du J, Hou L, Chen I, Kang C, Jin L, Wen J, Chen W, Lu Y. Real-Time Quantification of Cell Internalization Kinetics by Functionalized Bioluminescent Nanoprobes. Adv Mater. 2019 Sep; 31(39):e1902469. PMID: 31402525.
      View in: PubMed
    3. Wen J, Wu D, Qin M, Liu C, Wang L, Xu D, Vinters HV, Liu Y, Kranz E, Guan X, Sun G, Sun X, Lee Y, Martinez-Maza O, Widney D, Lu Y, Chen ISY, Kamata M. Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice. Nat Biomed Eng. 2019 Sep; 3(9):706-716. PMID: 31384008.
      View in: PubMed
    4. Xu D, Wu D, Qin M, Nih LR, Liu C, Cao Z, Ren J, Chen X, He Z, Yu W, Guan J, Duan S, Liu F, Liu X, Li J, Harley D, Xu B, Hou L, Chen ISY, Wen J, Chen W, Pourtaheri S, Lu Y. Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration. Adv Mater. 2019 Aug; 31(33):e1900727. PMID: 31125138.
      View in: PubMed
    5. Wu D, Qin M, Xu D, Wang L, Liu C, Ren J, Zhou G, Chen C, Yang F, Li Y, Zhao Y, Huang R, Pourtaheri S, Kang C, Kamata M, Chen ISY, He Z, Wen J, Chen W, Lu Y. A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System. Adv Mater. 2019 May; 31(18):e1807557. PMID: 30803073.
      View in: PubMed
    6. Xu S, Kim S, Chen ISY, Chou T. Modeling large fluctuations of thousands of clones during hematopoiesis: The role of stem cell self-renewal and bursty progenitor dynamics in rhesus macaque. PLoS Comput Biol. 2018 10; 14(10):e1006489. PMID: 30335762.
      View in: PubMed
    7. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2018 03; 14(3):e1006891. PMID: 29529058.
      View in: PubMed
    8. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2017 12; 13(12):e1006753. PMID: 29284044.
      View in: PubMed
    9. Khamaikawin W, Shimizu S, Kamata M, Cortado R, Jung Y, Lam J, Wen J, Kim P, Xie Y, Kim S, Arokium H, Presson AP, Chen ISY, An DS. Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:23-32. PMID: 29322065.
      View in: PubMed
    10. Chan J, Kim PY, Kranz E, Nagaoka Y, Lee Y, Wen J, Elsaesser HJ, Qin M, Brooks DG, Ringpis GE, Chen ISY, Kamata M. Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S59-S69. PMID: 29140111.
      View in: PubMed
    11. Suryawanshi GW, Xu S, Xie Y, Chou T, Kim N, Chen ISY, Kim S. Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow. J Vis Exp. 2017 06 14; (124). PMID: 28654067.
      View in: PubMed
    12. Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO. HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies. J Virol. 2016 08 01; 90(15):6999-7006. PMID: 27226366.
      View in: PubMed
    13. Wen J, Yan M, Liu Y, Li J, Xie Y, Lu Y, Kamata M, Chen IS. Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules. PLoS One. 2016; 11(4):e0151572. PMID: 27049645.
      View in: PubMed
    14. Goyal S, Kim S, Chen IS, Chou T. Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques. BMC Biol. 2015 Oct 20; 13:85. PMID: 26486451.
      View in: PubMed
    15. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. PMID: 26050990.
      View in: PubMed
    16. Yan M, Wen J, Liang M, Lu Y, Kamata M, Chen IS. Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs. PLoS One. 2015; 10(6):e0127986. PMID: 26035832.
      View in: PubMed
    17. Kamata M, Kim PY, Ng HL, Ringpis GE, Kranz E, Chan J, O'Connor S, Yang OO, Chen IS. Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4? CAR from HIV-1 infection and alleviates impairment of cell proliferation. Biochem Biophys Res Commun. 2015 Jul 31; 463(3):216-21. PMID: 25998390.
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    18. Burke BP, Levin BR, Zhang J, Sahakyan A, Boyer J, Carroll MV, Colón JC, Keech N, Rezek V, Bristol G, Eggers E, Cortado R, Boyd MP, Impey H, Shimizu S, Lowe EL, Ringpis GE, Kim SG, Vatakis DN, Breton LR, Bartlett JS, Chen IS, Kitchen SG, An DS, Symonds GP. Engineering Cellular Resistance to HIV-1 Infection In Vivo Using a Dual Therapeutic Lentiviral Vector. Mol Ther Nucleic Acids. 2015 Apr 14; 4:e236. PMID: 25872029.
      View in: PubMed
    19. Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen IS, An DS. RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice. Mol Ther Nucleic Acids. 2015 Feb 17; 4:e227. PMID: 25689223.
      View in: PubMed
    20. Arokium H, Kamata M, Kim S, Kim N, Liang M, Presson AP, Chen IS. Deep sequencing reveals low incidence of endogenous LINE-1 retrotransposition in human induced pluripotent stem cells. PLoS One. 2014; 9(10):e108682. PMID: 25289675.
      View in: PubMed
    21. Pang S, Pokomo L, Chen K, Kamata M, Mao SH, Zhang H, Razi E, An DS, Chen IS. High-throughput screening of effective siRNAs using luciferase-linked chimeric mRNA. PLoS One. 2014; 9(5):e96445. PMID: 24831610.
      View in: PubMed
    22. Wu C, Li B, Lu R, Koelle SJ, Yang Y, Jares A, Krouse AE, Metzger M, Liang F, Loré K, Wu CO, Donahue RE, Chen ISY, Weissman I, Dunbar CE. Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells. Cell Stem Cell. 2014 Apr 03; 14(4):486-499. PMID: 24702997.
      View in: PubMed
    23. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell Stem Cell. 2014 Apr 03; 14(4):473-85. PMID: 24702996.
      View in: PubMed
    24. Morizono K, Chen IS. Role of phosphatidylserine receptors in enveloped virus infection. J Virol. 2014 Apr; 88(8):4275-90. PMID: 24478428.
      View in: PubMed
    25. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. J Gene Med. 2014 Jan-Feb; 16(1-2):11-27. PMID: 24436117.
      View in: PubMed
    26. Sellers SE, Dumitriu B, Morgan MJ, Hughes WM, Wu CO, Raghavarchari N, Yang Y, Uchida N, Tisdale JF, An DS, Chen IS, Hematti P, Donahue RE, Larochelle A, Young NS, Calado RT, Dunbar CE. No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model. Mol Ther. 2014 Jan; 22(1):52-8. PMID: 23863881.
      View in: PubMed
    27. Liang M, Yan M, Lu Y, Chen IS. Retargeting vesicular stomatitis virus glycoprotein pseudotyped lentiviral vectors with enhanced stability by in situ synthesized polymer shell. Hum Gene Ther Methods. 2013 Feb; 24(1):11-8. PMID: 23327104.
      View in: PubMed
    28. Ringpis GE, Shimizu S, Arokium H, Camba-Colón J, Carroll MV, Cortado R, Xie Y, Kim PY, Sahakyan A, Lowe EL, Narukawa M, Kandarian FN, Burke BP, Symonds GP, An DS, Chen IS, Kamata M. Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice. PLoS One. 2012; 7(12):e53492. PMID: 23300932.
      View in: PubMed
    29. Yan M, Liang M, Wen J, Liu Y, Lu Y, Chen IS. Single siRNA nanocapsules for enhanced RNAi delivery. J Am Chem Soc. 2012 Aug 22; 134(33):13542-5. PMID: 22866878.
      View in: PubMed
    30. Presson AP, Kim N, Xiaofei Y, Chen IS, Kim S. Methodology and software to detect viral integration site hot-spots. BMC Bioinformatics. 2011 Sep 14; 12:367. PMID: 21914224.
      View in: PubMed
    31. Morizono K, Chen IS. Receptors and tropisms of envelope viruses. Curr Opin Virol. 2011 Jul; 1(1):13-8. PMID: 21804908.
      View in: PubMed
    32. Morizono K, Xie Y, Olafsen T, Lee B, Dasgupta A, Wu AM, Chen IS. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe. 2011 Apr 21; 9(4):286-98. PMID: 21501828.
      View in: PubMed
    33. Chen IS. Introduction. The UCLA AIDS Institute. Immunol Res. 2010 Dec; 48(1-3):1-2. PMID: 20703827.
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    34. Kamata M, Liu S, Liang M, Nagaoka Y, Chen IS. Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter. Hum Gene Ther. 2010 Nov; 21(11):1555-67. PMID: 20524893.
      View in: PubMed
    35. Kim S, Kim N, Presson AP, An DS, Mao SH, Bonifacino AC, Donahue RE, Chow SA, Chen IS. High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones. J Virol. 2010 Nov; 84(22):11771-80. PMID: 20844053.
      View in: PubMed
    36. Kamata M, Liang M, Liu S, Nagaoka Y, Chen IS. Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs. PLoS One. 2010 Jul 28; 5(7):e11834. PMID: 20676373.
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    37. Morizono K, Ku A, Xie Y, Harui A, Kung SK, Roth MD, Lee B, Chen IS. Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins. J Virol. 2010 Jul; 84(14):6923-34. PMID: 20484510.
      View in: PubMed
    38. Zhang KX, Kim C, Chow E, Chen IS, Jia W, Rennie PS. Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2. Breast Cancer Res Treat. 2011 Jan; 125(1):89-97. PMID: 20232140.
      View in: PubMed
    39. Liang M, Kamata M, Chen KN, Pariente N, An DS, Chen IS. Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction. J Gene Med. 2010 Mar; 12(3):255-65. PMID: 20186995.
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    40. Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 2010 Feb 25; 115(8):1534-44. PMID: 20018916.
      View in: PubMed
    41. Liang M, Morizono K, Pariente N, Kamata M, Lee B, Chen IS. Targeted transduction via CD4 by a lentiviral vector uses a clathrin-mediated entry pathway. J Virol. 2009 Dec; 83(24):13026-31. PMID: 19793825.
      View in: PubMed
    42. Arokium H, Kamata M, Chen I. Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells. J Virol. 2009 Nov; 83(21):11283-97. PMID: 19692467.
      View in: PubMed
    43. Morizono K, Xie Y, Helguera G, Daniels TR, Lane TF, Penichet ML, Chen IS. A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide. J Gene Med. 2009 Aug; 11(8):655-63. PMID: 19455593.
      View in: PubMed
    44. Morizono K, Pariente N, Xie Y, Chen IS. Redirecting lentiviral vectors by insertion of integrin-tageting peptides into envelope proteins. J Gene Med. 2009 Jul; 11(7):549-58. PMID: 19434609.
      View in: PubMed
    45. Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, Boyer J, Qin FX, An DS, Chen IS. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther. 2009 Jun 10; 7:8. PMID: 19515239.
      View in: PubMed
    46. Kamata M, Nagaoka Y, Chen IS. Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells. PLoS Pathog. 2009 Mar; 5(3):e1000342. PMID: 19300495.
      View in: PubMed
    47. Liang M, Pariente N, Morizono K, Chen IS. Targeted transduction of CD34+ hematopoietic progenitor cells in nonpurified human mobilized peripheral blood mononuclear cells. J Gene Med. 2009 Mar; 11(3):185-96. PMID: 19152374.
      View in: PubMed
    48. Kamata M, Susanto MT, Chen IS. Enhanced transthyretin tetramer stability following expression of an amyloid disease transsuppressor variant in mammalian cells. J Gene Med. 2009 Feb; 11(2):103-11. PMID: 19065606.
      View in: PubMed
    49. Wang Q, Zheng JY, Kreth J, Yan X, Kamata M, Campbell RA, Xie Y, Chiu R, Berenson JR, Shi W, Chen IS, Pang S. Regulation of prostate-specific antigen expression by the junctional adhesion molecule A. Urology. 2009 May; 73(5):1119-25. PMID: 18602143.
      View in: PubMed
    50. Kamata M, Watanabe N, Nagaoka Y, Chen IS. Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2. J Virol. 2008 Jun; 82(12):5672-82. PMID: 18385244.
      View in: PubMed
    51. Pariente N, Mao SH, Morizono K, Chen IS. Efficient targeted transduction of primary human endothelial cells with dual-targeted lentiviral vectors. J Gene Med. 2008 Mar; 10(3):242-8. PMID: 18074400.
      View in: PubMed
    52. Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int J Cancer. 2007 Nov 15; 121(10):2153-61. PMID: 17583576.
      View in: PubMed
    53. An DS, Donahue RE, Kamata M, Poon B, Metzger M, Mao SH, Bonifacino A, Krouse AE, Darlix JL, Baltimore D, Qin FX, Chen IS. Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13110-5. PMID: 17670939.
      View in: PubMed
    54. Poon B, Chang MA, Chen IS. Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. J Virol. 2007 Oct; 81(19):10515-23. PMID: 17652391.
      View in: PubMed
    55. Pariente N, Morizono K, Virk MS, Petrigliano FA, Reiter RE, Lieberman JR, Chen IS. A novel dual-targeted lentiviral vector leads to specific transduction of prostate cancer bone metastases in vivo after systemic administration. Mol Ther. 2007 Nov; 15(11):1973-81. PMID: 17653099.
      View in: PubMed
    56. Wang Q, Wang W, Zheng J, Tabibian S, Xie Y, Song J, Waring AJ, Chiu R, Yang OO, Chen IS, Lehrer RI, Pang S. Paradoxical effects of two theta-defensins on HIV type 1 infection. AIDS Res Hum Retroviruses. 2007 Apr; 23(4):508-14. PMID: 17506607.
      View in: PubMed
    57. An DS, Poon B, Ho Tsong Fang R, Weijer K, Blom B, Spits H, Chen IS, Uittenbogaart CH. Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection. Clin Vaccine Immunol. 2007 Apr; 14(4):391-6. PMID: 17314230.
      View in: PubMed
    58. Zheng J, Xie Y, Campbell R, Song J, Wang RQ, Chiu R, Berenson J, Razi M, Massachi S, Yang OO, Chen IS, Pang S. gp120-independent HIV infection of cells derived from the female reproductive tract, brain, and colon. J Acquir Immune Defic Syndr. 2006 Oct 01; 43(2):127-36. PMID: 16951651.
      View in: PubMed
    59. Morizono K, Ringpis GE, Pariente N, Xie Y, Chen IS. Transient low pH treatment enhances infection of lentiviral vector pseudotypes with a targeting Sindbis envelope. Virology. 2006 Nov 10; 355(1):71-81. PMID: 16905172.
      View in: PubMed
    60. Kamata M, Wu RP, An DS, Saxe JP, Damoiseaux R, Phelps ME, Huang J, Chen IS. Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):1101-6. PMID: 16904642.
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    61. Feeley BT, Conduah AH, Sugiyama O, Krenek L, Chen IS, Lieberman JR. In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models. J Orthop Res. 2006 Aug; 24(8):1709-21. PMID: 16788987.
      View in: PubMed
    62. An DS, Qin FX, Auyeung VC, Mao SH, Kung SK, Baltimore D, Chen IS. Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther. 2006 Oct; 14(4):494-504. PMID: 16844419.
      View in: PubMed
    63. Sander WE, Metzger ME, Morizono K, Bonifacino A, Penzak SR, Xie YM, Chen IS, Bacon J, Sestrich SG, Szajek LP, Donahue RE. Noninvasive molecular imaging to detect transgene expression of lentiviral vector in nonhuman primates. J Nucl Med. 2006 Jul; 47(7):1212-9. PMID: 16818958.
      View in: PubMed
    64. Zheng J, Xie Y, Campbell R, Song J, Massachi S, Razi M, Chiu R, Berenson J, Yang OO, Chen IS, Pang S. Involvement of claudin-7 in HIV infection of CD4(-) cells. Retrovirology. 2005 Dec 20; 2:79. PMID: 16368003.
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    65. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005 Oct; 3(4):377-92. PMID: 16250884.
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    66. Morizono K, Chen IS. Targeted gene delivery by intravenous injection of retroviral vectors. Cell Cycle. 2005 Jul; 4(7):854-6. PMID: 15970695.
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    67. Yuan H, Fu F, Zhuo J, Wang W, Nishitani J, An DS, Chen IS, Liu X. Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis. Oncogene. 2005 Jul 28; 24(32):5069-78. PMID: 15856013.
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    68. Kung SK, Bonifacino A, Metzger ME, Ringpis GE, Donahue RE, Chen IS. Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model. Hum Gene Ther. 2005 Apr; 16(4):527-32. PMID: 15871684.
      View in: PubMed
    69. Sugiyama O, An DS, Kung SP, Feeley BT, Gamradt S, Liu NQ, Chen IS, Lieberman JR. Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo. Mol Ther. 2005 Mar; 11(3):390-8. PMID: 15727935.
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    70. Morizono K, Xie Y, Ringpis GE, Johnson M, Nassanian H, Lee B, Wu L, Chen IS. Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat Med. 2005 Mar; 11(3):346-52. PMID: 15711560.
      View in: PubMed
    71. Zheng J, Yang OO, Xie Y, Campbell R, Chen IS, Pang S. Ethanol stimulation of HIV infection of oral epithelial cells. J Acquir Immune Defic Syndr. 2004 Dec 01; 37(4):1445-53. PMID: 15602121.
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    72. Donahue RE, Chen IS. Transgene-specific tolerance versus immune response. Blood. 2004 Sep 01; 104(5):1578-9; author reply 1579. PMID: 15317730.
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    73. Yuan H, Kamata M, Xie YM, Chen IS. Increased levels of Wee-1 kinase in G(2) are necessary for Vpr- and gamma irradiation-induced G(2) arrest. J Virol. 2004 Aug; 78(15):8183-90. PMID: 15254189.
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    74. Hui EK, Yap EM, An DS, Chen IS, Nayak DP. Inhibition of influenza virus matrix (M1) protein expression and virus replication by U6 promoter-driven and lentivirus-mediated delivery of siRNA. J Gen Virol. 2004 Jul; 85(Pt 7):1877-84. PMID: 15218172.
      View in: PubMed
    75. Kung SK, An DS, Bonifacino A, Metzger ME, Ringpis GE, Mao SH, Chen IS, Donahue RE. Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells. Mol Ther. 2003 Dec; 8(6):981-91. PMID: 14664801.
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    76. An DS, Xie Y, Mao SH, Morizono K, Kung SK, Chen IS. Efficient lentiviral vectors for short hairpin RNA delivery into human cells. Hum Gene Ther. 2003 Aug 10; 14(12):1207-12. PMID: 12908971.
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    77. Poon B, Chen IS. Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol. 2003 Apr; 77(7):3962-72. PMID: 12634356.
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    78. Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA. 2003 Apr; 9(4):493-501. PMID: 12649500.
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    79. Yuan H, Xie YM, Chen IS. Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis. J Virol. 2003 Feb; 77(3):2063-70. PMID: 12525641.
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    80. Donahue RE, Chen IS. Hematopoietic stem and progenitor cells. Methods Mol Biol. 2003; 229:117-30. PMID: 12824626.
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    81. Morizono K, De Ugarte DA, Zhu M, Zuk P, Elbarbary A, Ashjian P, Benhaim P, Chen IS, Hedrick MH. Multilineage cells from adipose tissue as gene delivery vehicles. Hum Gene Ther. 2003 Jan 01; 14(1):59-66. PMID: 12573059.
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    82. De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003; 174(3):101-9. PMID: 12835573.
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    83. Qin XF, An DS, Chen IS, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):183-8. PMID: 12518064.
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    84. Chow YH, Yu D, Zhang JY, Xie Y, Wei OL, Chiu C, Foroohar M, Yang OO, Park NH, Chen IS, Pang S. gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1. J Acquir Immune Defic Syndr. 2002 May 01; 30(1):1-8. PMID: 12048357.
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    85. Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BD. Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. J Virol. 2002 Feb; 76(4):1626-31. PMID: 11799157.
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