James U Bowie

Title(s)Recalled Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
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    Other Positions
    Title(s)Professor Emeritus, Chemistry and Biochemistry


    Collapse Biography 
    Collapse Education and Training
    Carleton College, Northfield, MNBA1981Chemistry
    Massachusetts Institute of Technology, Cambridge, MAPhD1989Biochemistry
    Collapse Awards and Honors
    Protein Society2020Stein&Moore Award
    Biophysical Society2018Society Fellow
    Academia Sinica2018Choh Hao Li Memorial Lecturer
    UCLA Postdoctoral Society2018Postdoctoral Mentoring Award Finalist
    Biophysical Society2017Anatrace Award for Membrane Proteins
    Kings College, London2016Higgs Lecturer
    Protein Society2012Elected President
    UCLA Postdoctoral Society2012Postdoctoral Mentoring Award
    Dreyfus Foundation2009Mentor
    Protein Society2008Elected to Executive Council
    AAAS2008Fellow
    Gordon Conference on Proteins2007Elected Chair
    Protein Society2006Elected to Executive Council
    FASEB Conf. on Mol. Biophys. of Cell Membranes2006Elected Chair
    Leukemia and Lymphoma Society2001Society Scholar
    UCLA Chemistry1998McCoy Award
    National Science Foundation1994National Young Investigator
    Pew1994Pew Scholar
    American Cancer Society1992Postdoctoral Fellowship
    Life Sciences Research Council1989Postdoctoral Fellowship
    Carleton College1981Distinction in Chemistry
    Phi Beta Kappa1981Phi Beta Kappa

    Collapse Research 
    Collapse Research Activities and Funding
    A SAM domain network in Polycystic Kidney Disease
    NIH R01DK100482Jan 1, 2014 - Dec 31, 2018
    Role: Principal Investigator
    The 27th Annual Symposium of The Protein Society
    NIH R13GM108328Jul 1, 2013 - Jun 30, 2014
    Role: Co-Principal Investigator
    Membrane Protein Folding
    NIH R13GM106694Apr 1, 2013 - Mar 31, 2014
    Role: Principal Investigator
    2011 Proteins
    NIH R13GM097944Apr 1, 2011 - Mar 31, 2012
    Role: Principal Investigator
    SAM Domains
    NIH R01GM093393Apr 1, 2010 - Mar 31, 2013
    Role: Principal Investigator
    Improving membrane protein crystallization
    NIH R01GM081783Sep 15, 2007 - Jul 31, 2010
    Role: Principal Investigator
    Formulatrix Automated Protein Crystallization System
    NIH S10RR023543Apr 1, 2007 - Mar 31, 2008
    Role: Principal Investigator
    FASEB Summer Conference on Molecular Biophysics of Cellular Membranes
    NIH R13GM079042Jun 15, 2006 - May 31, 2009
    Role: Principal Investigator
    Biacore T100
    NIH S10RR022417Mar 1, 2006 - Feb 28, 2007
    Role: Principal Investigator
    Generation of Membrane Protein Production Strains
    NIH R01GM075922Sep 23, 2005 - Jul 31, 2010
    Role: Principal Investigator
    ACT Database: Protein Structure-Function Relationships
    NIH R01LM007878Sep 30, 2003 - Sep 29, 2006
    Role: Principal Investigator
    Membrane Protein Folding
    NIH R01GM063919Aug 1, 2001 - Aug 31, 2022
    Role: Principal Investigator
    Structure/Function of SAM Domains
    NIH R01CA081000Jul 1, 1999 - Apr 30, 2009
    Role: Principal Investigator
    CRYSTALLIZATION OF DIACYLGLYCEROL KINASE
    NIH R01GM059164Jun 1, 1999 - May 31, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways. J Biol Chem. 2022 07; 298(7):102111. Aoki M, Vinokur J, Motoyama K, Ishikawa R, Collazo M, Cascio D, Sawaya MR, Ito T, Bowie JU, Hemmi H. PMID: 35690147; PMCID: PMC9254496.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. Expanding the use of ethanol as a feedstock for cell-free synthetic biochemistry by implementing acetyl-CoA and ATP generating pathways. Sci Rep. 2022 05 11; 12(1):7700. Liu H, Arbing MA, Bowie JU. PMID: 35546163; PMCID: PMC9095697.
      View in: PubMed   Mentions:    Fields:    
    3. How physical forces drive the process of helical membrane protein folding. EMBO Rep. 2022 02 03; 23(3):e53025. Corin K, Bowie JU. PMID: 35133709; PMCID: PMC8892262.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Cell-free synthetic biochemistry upgrading of ethanol to 1,3 butanediol. Sci Rep. 2021 05 03; 11(1):9449. Liu H, Bowie JU. PMID: 33941811; PMCID: PMC8093283.
      View in: PubMed   Mentions: 2     Fields:    
    5. How bilayer properties influence membrane protein folding. Protein Sci. 2020 12; 29(12):2348-2362. Corin K, Bowie JU. PMID: 33058341; PMCID: PMC7679971.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    6. Isobutanol production freed from biological limits using synthetic biochemistry. Nat Commun. 2020 08 27; 11(1):4292. Sherkhanov S, Korman TP, Chan S, Faham S, Liu H, Sawaya MR, Hsu WT, Vikram E, Cheng T, Bowie JU. PMID: 32855421; PMCID: PMC7453195.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    7. A bio-inspired cell-free system for cannabinoid production from inexpensive inputs. Nat Chem Biol. 2020 12; 16(12):1427-1433. Valliere MA, Korman TP, Arbing MA, Bowie JU. PMID: 32839605.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    8. Synthetic Biochemistry: The Bio-inspired Cell-Free Approach to Commodity Chemical Production. Trends Biotechnol. 2020 07; 38(7):766-778. Bowie JU, Sherkhanov S, Korman TP, Valliere MA, Opgenorth PH, Liu H. PMID: 31983463.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    9. Watching helical membrane proteins fold reveals a common N-to-C-terminal folding pathway. Science. 2019 11 29; 366(6469):1150-1156. Choi HK, Min D, Kang H, Shon MJ, Rah SH, Kim HC, Jeong H, Choi HJ, Bowie JU, Yoon TY. PMID: 31780561; PMCID: PMC7382370.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. Author Correction: A cell-free platform for the prenylation of natural products and application to cannabinoid production. Nat Commun. 2019 May 24; 10(1):2363. Valliere MA, Korman TP, Woodall NB, Khitrov GA, Taylor RE, Baker D, Bowie JU. PMID: 31127097; PMCID: PMC6534617.
      View in: PubMed   Mentions:    Fields:    
    11. A cell-free platform for the prenylation of natural products and application to cannabinoid production. Nat Commun. 2019 02 04; 10(1):565. Valliere MA, Korman TP, Woodall NB, Khitrov GA, Taylor RE, Baker D, Bowie JU. PMID: 30718485; PMCID: PMC6362252.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    12. Unfolding of a ClC chloride transporter retains memory of its evolutionary history. Nat Chem Biol. 2018 05; 14(5):489-496. Min D, Jefferson RE, Qi Y, Wang JY, Arbing MA, Im W, Bowie JU. PMID: 29581582; PMCID: PMC6038805.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    13. Accurate computational design of multipass transmembrane proteins. Science. 2018 03 02; 359(6379):1042-1046. Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D. PMID: 29496880; PMCID: PMC7328376.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    14. Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6. Structure. 2018 02 06; 26(2):209-224.e6. Roth? B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB. PMID: 29290488; PMCID: PMC6258031.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices. J Am Chem Soc. 2017 08 09; 139(31):10742-10749. Cao Z, Hutchison JM, Sanders CR, Bowie JU. PMID: 28692798; PMCID: PMC5560243.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    16. A molecular rheostat maintains ATP levels to drive a synthetic biochemistry system. Nat Chem Biol. 2017 Sep; 13(9):938-942. Opgenorth PH, Korman TP, Iancu L, Bowie JU. PMID: 28671683.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    17. A synthetic biochemistry platform for cell free production of monoterpenes from glucose. Nat Commun. 2017 05 24; 8:15526. Korman TP, Opgenorth PH, Bowie JU. PMID: 28537253; PMCID: PMC5458089.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    18. Applications of Single-Molecule Methods to Membrane Protein Folding Studies. J Mol Biol. 2018 02 16; 430(4):424-437. Jefferson RE, Min D, Corin K, Wang JY, Bowie JU. PMID: 28549924; PMCID: PMC5700846.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Complete topology inversion can be part of normal membrane protein biogenesis. Protein Sci. 2017 04; 26(4):824-833. Woodall NB, Hadley S, Yin Y, Bowie JU. PMID: 28168866; PMCID: PMC5368078.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    20. An Adaptation To Life In Acid Through A Novel Mevalonate Pathway. Sci Rep. 2016 12 22; 6:39737. Vinokur JM, Cummins MC, Korman TP, Bowie JU. PMID: 28004831; PMCID: PMC5177888.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    21. A simple DNA handle attachment method for single molecule mechanical manipulation experiments. Protein Sci. 2016 08; 25(8):1535-44. Min D, Arbing MA, Jefferson RE, Bowie JU. PMID: 27222403; PMCID: PMC4972209.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    22. A synthetic biochemistry module for production of bio-based chemicals from glucose. Nat Chem Biol. 2016 06; 12(6):393-5. Opgenorth PH, Korman TP, Bowie JU. PMID: 27065234.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    23. Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme. Sci Rep. 2016 Apr 07; 6:24239. Sherkhanov S, Korman TP, Clarke SG, Bowie JU. PMID: 27053100; PMCID: PMC4823748.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    24. Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Genome Res. 2016 Feb; 26(2):183-91. Spielmann M, Kakar N, Tayebi N, Leettola C, N?rnberg G, Sowada N, Lupi??ez DG, Harabula I, Fl?ttmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altm?ller J, Thiele H, van Bokhoven H, Schwartz CE, N?rnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G. PMID: 26755636; PMCID: PMC4728371.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. Molecular dynamics simulation strategies for protein-micelle complexes. Biochim Biophys Acta. 2016 Jul; 1858(7 Pt B):1566-72. Cheng X, Kim JK, Kim Y, Bowie JU, Im W. PMID: 26679426; PMCID: PMC4877248.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    26. Mapping the energy landscape for second-stage folding of a single membrane protein. Nat Chem Biol. 2015 Dec; 11(12):981-7. Min D, Jefferson RE, Bowie JU, Yoon TY. PMID: 26479439; PMCID: PMC4986997.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    27. Dual-topology insertion of a dual-topology membrane protein. Nat Commun. 2015 Aug 26; 6:8099. Woodall NB, Yin Y, Bowie JU. PMID: 26306475; PMCID: PMC4560821.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    28. Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network. Sci Rep. 2015 Apr 29; 5:9576. Nam HJ, Kim I, Bowie JU, Kim S. PMID: 25923201; PMCID: PMC4894438.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. Protein Sci. 2015 Feb; 24(2):212-20. Vinokur JM, Korman TP, Sawaya MR, Collazo M, Cascio D, Bowie JU. PMID: 25422158; PMCID: PMC4315659.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    30. Bacteriorhodopsin folds through a poorly organized transition state. J Am Chem Soc. 2014 Nov 26; 136(47):16574-81. Schlebach JP, Woodall NB, Bowie JU, Park C. PMID: 25369295; PMCID: PMC4277764.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    31. Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. BMC Struct Biol. 2014 Jul 07; 14:17. Leettola CN, Knight MJ, Cascio D, Hoffman S, Bowie JU. PMID: 24998259; PMCID: PMC4105859.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Evidence of a novel mevalonate pathway in archaea. Biochemistry. 2014 Jul 01; 53(25):4161-8. Vinokur JM, Korman TP, Cao Z, Bowie JU. PMID: 24914732; PMCID: PMC4081127.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    33. A synthetic biochemistry molecular purge valve module that maintains redox balance. Nat Commun. 2014 Jun 17; 5:4113. Opgenorth PH, Korman TP, Bowie JU. PMID: 24936528.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    34. Improving the tolerance of Escherichia coli to medium-chain fatty acid production. Metab Eng. 2014 Sep; 25:1-7. Sherkhanov S, Korman TP, Bowie JU. PMID: 24932721.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    35. An energetic scale for equilibrium H/D fractionation factors illuminates hydrogen bond free energies in proteins. Protein Sci. 2014 May; 23(5):566-75. Cao Z, Bowie JU. PMID: 24501090; PMCID: PMC4005708.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. Protein Sci. 2014 May; 23(5):576-85. Korman TP, Sahachartsiri B, Li D, Vinokur JM, Eisenberg D, Bowie JU. PMID: 24623472; PMCID: PMC4005709.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    37. Measuring membrane protein stability under native conditions. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):219-24. Chang YC, Bowie JU. PMID: 24367094; PMCID: PMC3890813.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    38. Membrane proteins can have high kinetic stability. J Am Chem Soc. 2013 Oct 09; 135(40):15183-90. Jefferson RE, Blois TM, Bowie JU. PMID: 24032628; PMCID: PMC3839629.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    39. Dieselzymes: development of a stable and methanol tolerant lipase for biodiesel production by directed evolution. Biotechnol Biofuels. 2013 May 07; 6(1):70. Korman TP, Sahachartsiri B, Charbonneau DM, Huang GL, Beauregard M, Bowie JU. PMID: 23648063; PMCID: PMC3670234.
      View in: PubMed   Mentions: 25  
    40. Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. PLoS Comput Biol. 2013; 9(3):e1002997. Nam HJ, Han SK, Bowie JU, Kim S. PMID: 23555228; PMCID: PMC3605051.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    41. Structural biology. Membrane protein twists and turns. Science. 2013 Jan 25; 339(6118):398-9. Bowie JU. PMID: 23349275.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    42. Measuring transmembrane helix interaction strengths in lipid bilayers using steric trapping. Methods Mol Biol. 2013; 1063:37-56. Hong H, Chang YC, Bowie JU. PMID: 23975771; PMCID: PMC4986992.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    43. Crystal structure of Proteus mirabilis lipase, a novel lipase from the Proteus/psychrophilic subfamily of lipase family I.1. PLoS One. 2012; 7(12):e52890. Korman TP, Bowie JU. PMID: 23300806; PMCID: PMC3530535.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    44. Network rewiring is an important mechanism of gene essentiality change. Sci Rep. 2012; 2:900. Kim J, Kim I, Han SK, Bowie JU, Kim S. PMID: 23198090; PMCID: PMC3509348.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    45. Structural differences between thermophilic and mesophilic membrane proteins. Protein Sci. 2012 Nov; 21(11):1746-53. Meruelo AD, Han SK, Kim S, Bowie JU. PMID: 23001966; PMCID: PMC3527711.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    46. Shifting hydrogen bonds may produce flexible transmembrane helices. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8121-6. Cao Z, Bowie JU. PMID: 22566663; PMCID: PMC3361389.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    47. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 07; 19(12):1826-36. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. PMID: 22153505; PMCID: PMC3240820.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    48. Revisiting the folding kinetics of bacteriorhodopsin. Protein Sci. 2012 Jan; 21(1):97-106. Schlebach JP, Cao Z, Bowie JU, Park C. PMID: 22095725; PMCID: PMC3323784.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    49. Crystallizing membrane proteins using lipidic bicelles. Methods. 2011 Dec; 55(4):337-41. Ujwal R, Bowie JU. PMID: 21982781; PMCID: PMC3264687.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    50. Thermodynamic stability of bacteriorhodopsin mutants measured relative to the bacterioopsin unfolded state. Biochim Biophys Acta. 2012 Apr; 1818(4):1049-54. Cao Z, Schlebach JP, Park C, Bowie JU. PMID: 21880269; PMCID: PMC3272320.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    51. A human sterile alpha motif domain polymerizome. Protein Sci. 2011 Oct; 20(10):1697-706. Knight MJ, Leettola C, Gingery M, Li H, Bowie JU. PMID: 21805519; PMCID: PMC3218363.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    52. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J Mol Biol. 2011 Sep 09; 412(1):3-13. Stafford RL, Ear J, Knight MJ, Bowie JU. PMID: 21763699; PMCID: PMC3158819.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    53. Dramatic destabilization of transmembrane helix interactions by features of natural membrane environments. J Am Chem Soc. 2011 Jul 27; 133(29):11389-98. Hong H, Bowie JU. PMID: 21682279; PMCID: PMC3140635.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    54. TMKink: a method to predict transmembrane helix kinks. Protein Sci. 2011 Jul; 20(7):1256-64. Meruelo AD, Samish I, Bowie JU. PMID: 21563225; PMCID: PMC3149198.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    55. Crystal structure of the central coiled-coil domain from human liprin-�2. Biochemistry. 2011 May 10; 50(18):3807-15. Stafford RL, Tang MY, Sawaya MR, Phillips ML, Bowie JU. PMID: 21462929; PMCID: PMC3093129.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    56. Probing membrane protein unfolding with pulse proteolysis. J Mol Biol. 2011 Mar 04; 406(4):545-51. Schlebach JP, Kim MS, Joh NH, Bowie JU, Park C. PMID: 21192947; PMCID: PMC3039306.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    57. Membrane protein folding: how important are hydrogen bonds? Curr Opin Struct Biol. 2011 Feb; 21(1):42-9. Bowie JU. PMID: 21075614; PMCID: PMC3073540.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    58. Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase d. Biochemistry. 2010 Nov 09; 49(44):9667-76. Knight MJ, Joubert MK, Plotkowski ML, Kropat J, Gingery M, Sakane F, Merchant SS, Bowie JU. PMID: 20857926; PMCID: PMC3035719.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    59. Method to measure strong protein-protein interactions in lipid bilayers using a steric trap. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):19802-7. Hong H, Blois TM, Cao Z, Bowie JU. PMID: 21041662; PMCID: PMC2993359.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    60. Regulation of clathrin adaptor function in endocytosis: novel role for the SAM domain. EMBO J. 2010 Mar 17; 29(6):1033-44. Di Pietro SM, Cascio D, Feliciano D, Bowie JU, Payne GS. PMID: 20150898; PMCID: PMC2845277.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    61. Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation. Mol Cell Proteomics. 2010 May; 9(5):791-803. Ryan CM, Souda P, Bassilian S, Ujwal R, Zhang J, Abramson J, Ping P, Durazo A, Bowie JU, Hasan SS, Baniulis D, Cramer WA, Faull KF, Whitelegge JP. PMID: 20093275; PMCID: PMC2871414.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    62. Protein unfolding with a steric trap. J Am Chem Soc. 2009 Oct 07; 131(39):13914-5. Blois TM, Hong H, Kim TH, Bowie JU. PMID: 19739627; PMCID: PMC2790274.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    63. Structural imperatives impose diverse evolutionary constraints on helical membrane proteins. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17747-50. Oberai A, Joh NH, Pettit FK, Bowie JU. PMID: 19815527; PMCID: PMC2764890.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    64. Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J Am Chem Soc. 2009 Aug 12; 131(31):10846-7. Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU. PMID: 19603754; PMCID: PMC2744480.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    65. G-protein-coupled receptor structures were not built in a day. Protein Sci. 2009 Jul; 18(7):1335-42. Blois TM, Bowie JU. PMID: 19536805; PMCID: PMC2775204.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    66. Genetic selection system for improving recombinant membrane protein expression in E. coli. Protein Sci. 2009 Feb; 18(2):372-83. Massey-Gendel E, Zhao A, Boulting G, Kim HY, Balamotis MA, Seligman LM, Nakamoto RK, Bowie JU. PMID: 19165721; PMCID: PMC2708063.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    67. Methods for measuring the thermodynamic stability of membrane proteins. Methods Enzymol. 2009; 455:213-36. Hong H, Joh NH, Bowie JU, Tamm LK. PMID: 19289208.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    68. Identifying polymer-forming SAM domains. Proteins. 2009 Jan; 74(1):1-5. Meruelo AD, Bowie JU. PMID: 18831011; PMCID: PMC2605191.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    69. Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins. Nature. 2008 Jun 26; 453(7199):1266-70. Joh NH, Min A, Faham S, Whitelegge JP, Yang D, Woods VL, Bowie JU. PMID: 18500332; PMCID: PMC2734483.
      View in: PubMed   Mentions: 102     Fields:    Translation:Cells
    70. Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1. Structure. 2008 Mar; 16(3):380-7. Harada BT, Knight MJ, Imai S, Qiao F, Ramachander R, Sawaya MR, Gingery M, Sakane F, Bowie JU. PMID: 18334213.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    71. Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. BMC Neurosci. 2008 Jan 30; 9:17. Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A. PMID: 18234110; PMCID: PMC2266763.
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    72. Point mutations in membrane proteins reshape energy landscape and populate different unfolding pathways. J Mol Biol. 2008 Feb 29; 376(4):1076-90. Sapra KT, Balasubramanian GP, Labudde D, Bowie JU, Muller DJ. PMID: 18191146; PMCID: PMC2742699.
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    73. Polymer-driven crystallization. Protein Sci. 2007 Nov; 16(11):2542-51. Nauli S, Farr S, Lee YJ, Kim HY, Faham S, Bowie JU. PMID: 17962407; PMCID: PMC2211692.
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    74. Transmembrane domain of myelin protein zero can form dimers: possible implications for myelin construction. Biochemistry. 2007 Oct 30; 46(43):12164-73. Plotkowski ML, Kim S, Phillips ML, Partridge AW, Deber CM, Bowie JU. PMID: 17915947.
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    75. HotPatch: a statistical approach to finding biologically relevant features on protein surfaces. J Mol Biol. 2007 Jun 08; 369(3):863-79. Pettit FK, Bare E, Tsai A, Bowie JU. PMID: 17451744; PMCID: PMC2034327.
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    76. Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization. J Mol Biol. 2007 Jan 19; 365(3):706-14. Barwe SP, Kim S, Rajasekaran SA, Bowie JU, Rajasekaran AK. PMID: 17078968; PMCID: PMC2459552.
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    77. A limited universe of membrane protein families and folds. Protein Sci. 2006 Jul; 15(7):1723-34. Oberai A, Ihm Y, Kim S, Bowie JU. PMID: 16815920; PMCID: PMC2242558.
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    78. A role for zinc in postsynaptic density asSAMbly and plasticity? Trends Biochem Sci. 2006 Jul; 31(7):366-73. Gundelfinger ED, Boeckers TM, Baron MK, Bowie JU. PMID: 16793273.
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    79. Flip-flopping membrane proteins. Nat Struct Mol Biol. 2006 Feb; 13(2):94-6. Bowie JU. PMID: 16462808.
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    80. An architectural framework that may lie at the core of the postsynaptic density. Science. 2006 Jan 27; 311(5760):531-5. Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU. PMID: 16439662.
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    81. Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site. EMBO J. 2006 Jan 11; 25(1):70-9. Qiao F, Harada B, Song H, Whitelegge J, Courey AJ, Bowie JU. PMID: 16362034; PMCID: PMC1356365.
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    82. Solving the membrane protein folding problem. Nature. 2005 Dec 01; 438(7068):581-9. Bowie JU. PMID: 16319877.
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    83. Transmembrane glycine zippers: physiological and pathological roles in membrane proteins. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14278-83. Kim S, Jeon TJ, Oberai A, Yang D, Schmidt JJ, Bowie JU. PMID: 16179394; PMCID: PMC1242278.
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    84. How to prepare membrane proteins for solid-state NMR: A case study on the alpha-helical integral membrane protein diacylglycerol kinase from E. coli. Chembiochem. 2005 Sep; 6(9):1693-700. Lorch M, Faham S, Kaiser C, Weber I, Mason AJ, Bowie JU, Glaubitz C. PMID: 16138309.
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    85. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Genes Dev. 2005 Aug 01; 19(15):1767-72. Song H, Nie M, Qiao F, Bowie JU, Courey AJ. PMID: 16027171; PMCID: PMC1182338.
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    86. The many faces of SAM. Sci STKE. 2005 May 31; 2005(286):re7. Qiao F, Bowie JU. PMID: 15928333.
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    87. Structural organization of a Sex-comb-on-midleg/polyhomeotic copolymer. J Biol Chem. 2005 Jul 29; 280(30):27769-75. Kim CA, Sawaya MR, Cascio D, Kim W, Bowie JU. PMID: 15905166.
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    88. Crystallization of bacteriorhodopsin from bicelle formulations at room temperature. Protein Sci. 2005 Mar; 14(3):836-40. Faham S, Boulting GL, Massey EA, Yohannan S, Yang D, Bowie JU. PMID: 15689517; PMCID: PMC2279272.
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    89. Cell biology: border crossing. Nature. 2005 Jan 27; 433(7024):367-9. Bowie JU. PMID: 15674274.
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    90. Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel. Nat Struct Mol Biol. 2005 Feb; 12(2):113-9. Edwards MD, Li Y, Kim S, Miller S, Bartlett W, Black S, Dennison S, Iscla I, Blount P, Bowie JU, Booth IR. PMID: 15665866.
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    91. Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. J Biol Chem. 2005 Feb 25; 280(8):7294-300. Partridge AW, Liu S, Kim S, Bowie JU, Ginsberg MH. PMID: 15591321.
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    92. SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers. J Mol Biol. 2004 Oct 01; 342(5):1353-8. Ramachander R, Bowie JU. PMID: 15364564.
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    93. Analysis of side-chain rotamers in transmembrane proteins. Biophys J. 2004 Nov; 87(5):3460-9. Chamberlain AK, Bowie JU. PMID: 15339811; PMCID: PMC1304812.
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    94. Asymmetric amino acid compositions of transmembrane beta-strands. Protein Sci. 2004 Aug; 13(8):2270-4. Chamberlain AK, Bowie JU. PMID: 15273317; PMCID: PMC2279826.
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    95. A model of the closed form of the nicotinic acetylcholine receptor m2 channel pore. Biophys J. 2004 Aug; 87(2):792-9. Kim S, Chamberlain AK, Bowie JU. PMID: 15298888; PMCID: PMC1304489.
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    96. Proline substitutions are not easily accommodated in a membrane protein. J Mol Biol. 2004 Jul 30; 341(1):1-6. Yohannan S, Yang D, Faham S, Boulting G, Whitelegge J, Bowie JU. PMID: 15312757.
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    97. Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Cell. 2004 Jul 23; 118(2):163-73. Qiao F, Song H, Kim CA, Sawaya MR, Hunter JB, Gingery M, Rebay I, Courey AJ, Bowie JU. PMID: 15260987.
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    98. Snorkeling preferences foster an amino acid composition bias in transmembrane helices. J Mol Biol. 2004 May 28; 339(2):471-9. Chamberlain AK, Lee Y, Kim S, Bowie JU. PMID: 15136048.
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    99. Secondary structure and backbone dynamics of Escherichia coli diacylglycerol kinase, as revealed by site-directed solid-state 13C NMR. Biochim Biophys Acta. 2004 Apr 08; 1698(1):97-105. Yamaguchi S, Tuzi S, Bowie JU, Sait? H. PMID: 15063319.
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    100. Membrane channel structure of Helicobacter pylori vacuolating toxin: role of multiple GXXXG motifs in cylindrical channels. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):5988-91. Kim S, Chamberlain AK, Bowie JU. PMID: 15067113; PMCID: PMC395910.
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    101. Membrane proteins: a new method enters the fold. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):3995-6. Bowie JU. PMID: 15024105; PMCID: PMC384682.
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    102. A C alpha-H...O hydrogen bond in a membrane protein is not stabilizing. J Am Chem Soc. 2004 Mar 03; 126(8):2284-5. Yohannan S, Faham S, Yang D, Grosfeld D, Chamberlain AK, Bowie JU. PMID: 14982414.
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    103. The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem. 2004 Apr 16; 279(16):16591-7. Melnyk RA, Kim S, Curran AR, Engelman DM, Bowie JU, Deber CM. PMID: 14766751.
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    104. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):959-63. Yohannan S, Faham S, Yang D, Whitelegge JP, Bowie JU. PMID: 14732697; PMCID: PMC327124.
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    105. Side-chain contributions to membrane protein structure and stability. J Mol Biol. 2004 Jan 02; 335(1):297-305. Faham S, Yang D, Bare E, Yohannan S, Whitelegge JP, Bowie JU. PMID: 14659758.
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    106. The Database of Interacting Proteins: 2004 update. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D449-51. Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D. PMID: 14681454; PMCID: PMC308820.
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    107. SAM domains: uniform structure, diversity of function. Trends Biochem Sci. 2003 Dec; 28(12):625-8. Kim CA, Bowie JU. PMID: 14659692.
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    108. A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen. Mol Biol Cell. 2003 Dec; 14(12):4835-45. Rajasekaran SA, Anilkumar G, Oshima E, Bowie JU, Liu H, Heston W, Bander NH, Rajasekaran AK. PMID: 14528023; PMCID: PMC284788.
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    109. A simple method for modeling transmembrane helix oligomers. J Mol Biol. 2003 Jun 13; 329(4):831-40. Kim S, Chamberlain AK, Bowie JU. PMID: 12787681.
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    110. A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity. J Biol Chem. 2003 Jun 13; 278(24):22056-60. Partridge AW, Melnyk RA, Yang D, Bowie JU, Deber CM. PMID: 12686537.
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    111. Construction of helix-bundle membrane proteins. Adv Protein Chem. 2003; 63:19-46. Chamberlain AK, Faham S, Yohannan S, Bowie JU. PMID: 12629965.
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    112. Evaluation of C-H cdots, three dots, centered O hydrogen bonds in native and misfolded proteins. J Mol Biol. 2002 Sep 20; 322(3):497-503. Chamberlain AK, Bowie JU. PMID: 12225744.
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    113. Native interface of the SAM domain polymer of TEL. BMC Struct Biol. 2002 Aug 22; 2:5. Tran HH, Kim CA, Faham S, Siddall MC, Bowie JU. PMID: 12193272; PMCID: PMC126206.
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    114. Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4. J Biol Chem. 2002 Oct 18; 277(42):39585-93. Ramachander R, Kim CA, Phillips ML, Mackereth CD, Thanos CD, McIntosh LP, Bowie JU. PMID: 12171939.
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    115. The SAM domain of polyhomeotic forms a helical polymer. Nat Struct Biol. 2002 Jun; 9(6):453-7. Kim CA, Gingery M, Pilpa RM, Bowie JU. PMID: 11992127.
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    116. Bicelle crystallization: a new method for crystallizing membrane proteins yields a monomeric bacteriorhodopsin structure. J Mol Biol. 2002 Feb 08; 316(1):1-6. Faham S, Bowie JU. PMID: 11829498.
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    117. Stabilizing membrane proteins. Curr Opin Struct Biol. 2001 Aug; 11(4):397-402. Bowie JU. PMID: 11495729.
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    118. Helix-bundle membrane protein fold templates. Protein Sci. 1999 Dec; 8(12):2711-9. Bowie JU. PMID: 10631987; PMCID: PMC2144225.
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    119. Helix packing angle preferences. Nat Struct Biol. 1997 Nov; 4(11):915-7. Bowie JU. PMID: 9360607.
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