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Hansen James E

Title(s)Professor Emeritus, RESPIRATORY & CRITICAL CARE PHYSIOLOGY & MEDICINE
SchoolThe Lundquist Institute for Biomedical Innovation
Phone(310) 222-3803
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    Title(s)Professor, Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hansen JE, Dilektasli AG, Porszasz J, Stringer WW, Pak Y, Rossiter HB, Casaburi R. A New Bronchodilator Response Grading Strategy Identifies Distinct Patient Populations. Ann Am Thorac Soc. 2019 Dec; 16(12):1504-1517. PMID: 31404502.
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    2. Kim CH, Van Iterson EH, Hansen JE, MacCarter DJ, Johnson BD. Streamlining cardiopulmonary exercise testing for use as a screening and tracking tool in primary care. Pulm Circ. 2018 Apr-Jun; 8(2):2045894018776489. PMID: 29693481.
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    3. Loganadane G, Kelly JR, Lee NC, Kann BH, Mahajan A, Hansen JE, Belkacémi Y, Yarbrough W, Husain ZA. Incidence of radiographically occult nodal metastases in HPV+ oropharyngeal carcinoma: Implications for reducing elective nodal coverage. Pract Radiat Oncol. 2018 Nov - Dec; 8(6):397-403. PMID: 29730282.
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    4. Tan C, Rossiter HB, Porszasz J, Bowen TS, Witte KK, Stringer WW, Casaburi R, Hansen JE. Reliability and Physiological Interpretation of Pulmonary Gas Exchange by "Circulatory Equivalents" in Chronic Heart Failure. J Am Heart Assoc. 2018 03 27; 7(7). PMID: 29588313.
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    5. Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin PR, Yelin EH, Ginzler E, Hanly JG, Peschken C, Gordon C, Nived O, Aranow C, Bae SC, Isenberg D, Rahman A, Hansen JE, Pierre YS, Clarke AE. Smoking Is the Most Significant Modifiable Lung Cancer Risk Factor in Systemic Lupus Erythematosus. J Rheumatol. 2018 03; 45(3):393-396. PMID: 29335347.
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    6. Dilektasli AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, Estepar RSJ, Hansen JE. A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria. Chest. 2016 Nov; 150(5):1080-1090. PMID: 27452770.
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    7. Yao YX, Sun XG, Zheng Z, Wang GZ, Hansen JE, Stringer WW, Wasserman K, Hu SS. Better parameters of ventilation-CO2output relationship predict death in CHF patients. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov; 31(6):508-16. PMID: 27215018.
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    8. Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE. DNA-dependent targeting of cell nuclei by a lupus autoantibody. Sci Rep. 2015 Jul 09; 5:12022. PMID: 26156563.
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    9. Noble PW, Chan G, Young MR, Weisbart RH, Hansen JE. Optimizing a lupus autoantibody for targeted cancer therapy. Cancer Res. 2015 Jun 01; 75(11):2285-91. PMID: 25832653.
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    10. Hansen JE, Porszasz J, Casaburi R, Stringer WW. Re-Defining Lower Limit of Normal for FEV1/FEV6, FEV1/FVC, FEV3/FEV6 and FEV3/FVC to Improve Detection of Airway Obstruction. Chronic Obstr Pulm Dis. 2015 Mar 10; 2(2):94-102. PMID: 28848835.
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    11. Hansen JE, Porszasz J. Counterpoint: Is an increase in FEV1 and/or FVC = 12% of control and = 200 mL the best way to assess positive bronchodilator response? No. Chest. 2014 Sep; 146(3):538-541. PMID: 25180718.
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    12. Hansen JE, Porszasz J. Rebuttal from Drs Hansen and Porszasz. Chest. 2014 Sep; 146(3):542-544. PMID: 25180720.
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    13. Noble PW, Young MR, Bernatsky S, Weisbart RH, Hansen JE. A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells. Sci Rep. 2014 Aug 05; 4:5958. PMID: 25091037.
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    14. Hansen JE. Human lung acinar structure and function are even better than good. Am J Respir Crit Care Med. 2013 Sep 01; 188(5):623. PMID: 23992592.
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    15. Gläser S, Ittermann T, Koch B, Schäper C, Felix SB, Völzke H, Könemann R, Ewert R, Hansen JE. Influence of smoking and obesity on alveolar-arterial gas pressure differences and dead space ventilation at rest and peak exercise in healthy men and women. Respir Med. 2013 Jun; 107(6):919-26. PMID: 23510666.
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    16. Hansen JE. Hooray for the VA/TLC and DL(CO)/VA. Am J Respir Crit Care Med. 2013 Jan 01; 187(1):107. PMID: 23281352.
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    17. Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM. Targeting cancer with a lupus autoantibody. Sci Transl Med. 2012 Oct 24; 4(157):157ra142. PMID: 23100628.
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    18. Weisbart RH, Gera JF, Chan G, Hansen JE, Li E, Cloninger C, Levine AJ, Nishimura RN. A cell-penetrating bispecific antibody for therapeutic regulation of intracellular targets. Mol Cancer Ther. 2012 Oct; 11(10):2169-73. PMID: 22863609.
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    19. Hansen JE, Sun XG, Stringer WW. A simple new visualization of exercise data discloses pathophysiology and severity of heart failure. J Am Heart Assoc. 2012 Jun; 1(3):e001883. PMID: 23130146.
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    20. Hansen JE. Has my patient responded? Am J Respir Crit Care Med. 2012 Apr 15; 185(8):895; author reply 895; discussion 896. PMID: 22505756.
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    21. Hansen JE. A better way to assess bronchoreversibility. Chest. 2012 Apr; 141(4):1118. PMID: 22474156.
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    22. Sun XG, Hansen JE, Stringer WW. Oxygen uptake efficiency plateau best predicts early death in heart failure. Chest. 2012 May; 141(5):1284-1294. PMID: 22030802.
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    23. Sun XG, Hansen JE, Stringer WW. Oxygen uptake efficiency plateau: physiology and reference values. Eur J Appl Physiol. 2012 Mar; 112(3):919-28. PMID: 21695524.
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    24. Hansen JE. Lower limit of normal is better than 70% or 80%. Chest. 2011 Jan; 139(1):6-8. PMID: 21208872.
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    25. Dumitrescu D, Oudiz RJ, Karpouzas G, Hovanesyan A, Jayasinghe A, Hansen JE, Rosenkranz S, Wasserman K. Developing pulmonary vasculopathy in systemic sclerosis, detected with non-invasive cardiopulmonary exercise testing. PLoS One. 2010 Dec 13; 5(12):e14293. PMID: 21179195.
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    26. Chaudhry S, Arena RA, Hansen JE, Lewis GD, Myers JN, Sperling LS, Labudde BD, Wasserman K. The utility of cardiopulmonary exercise testing to detect and track early-stage ischemic heart disease. Mayo Clin Proc. 2010 Oct; 85(10):928-32. PMID: 20884826.
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    27. Hansen J. Measuring the lung age of smokers. Prim Care Respir J. 2010 Sep; 19(3):286-7; author reply 287. PMID: 20676592.
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    28. Gläser S, Koch B, Ittermann T, Schäper C, Dörr M, Felix SB, Völzke H, Ewert R, Hansen JE. Influence of age, sex, body size, smoking, and beta blockade on key gas exchange exercise parameters in an adult population. Eur J Cardiovasc Prev Rehabil. 2010 Aug; 17(4):469-76. PMID: 20305565.
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    29. Sun XG, Hansen JE, Beshai JF, Wasserman K. Oscillatory breathing and exercise gas exchange abnormalities prognosticate early mortality and morbidity in heart failure. J Am Coll Cardiol. 2010 Apr 27; 55(17):1814-23. PMID: 20413031.
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    30. Oudiz RJ, Midde R, Hovenesyan A, Sun XG, Roveran G, Hansen JE, Wasserman K. Usefulness of right-to-left shunting and poor exercise gas exchange for predicting prognosis in patients with pulmonary arterial hypertension. Am J Cardiol. 2010 Apr 15; 105(8):1186-91. PMID: 20381675.
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    31. Zhan X, Ander BP, Liao IH, Hansen JE, Kim C, Clements D, Weisbart RH, Nishimura RN, Sharp FR. Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke. 2010 Mar; 41(3):538-43. PMID: 20075343.
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    32. Heinze E, Baldwin S, Chan G, Hansen J, Song J, Clements D, Aragon R, Nishimura R, Reeves M, Weisbart R. Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo. Int J Oncol. 2009 Jul; 35(1):167-73. PMID: 19513564.
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    33. Chaudhry S, Arena R, Wasserman K, Hansen JE, Lewis GD, Myers J, Belardinelli R, LaBudde B, Menasco N, Boden WE. The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia. Int J Cardiol. 2011 Apr 01; 148(1):e7-9. PMID: 19233492.
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    34. Robbins JL, Duscha BD, Bensimhon DR, Wasserman K, Hansen JE, Houmard JA, Annex BH, Kraus WE. A sex-specific relationship between capillary density and anaerobic threshold. J Appl Physiol (1985). 2009 Apr; 106(4):1181-6. PMID: 19164774.
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    35. Chaudhry S, Arena R, Wasserman K, Hansen JE, Lewis GD, Myers J, Chronos N, Boden WE. Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. Am J Cardiol. 2009 Mar 01; 103(5):615-9. PMID: 19231322.
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    36. Hansen JE, Sun XG, Adame D, Wasserman K. Argument for changing criteria for bronchodilator responsiveness. Respir Med. 2008 Dec; 102(12):1777-83. PMID: 18701269.
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    37. Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol Chem. 2008 May 16; 283(20):14132-43. PMID: 18347024.
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    38. Oudiz RJ, Roveran G, Hansen JE, Sun XG, Wasserman K. Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension. Eur J Heart Fail. 2007 Sep; 9(9):917-21. PMID: 17707133.
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    39. Hansen JE, Ulubay G, Chow BF, Sun XG, Wasserman K. Mixed-expired and end-tidal CO2 distinguish between ventilation and perfusion defects during exercise testing in patients with lung and heart diseases. Chest. 2007 Sep; 132(3):977-83. PMID: 17573506.
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    40. Hansen JE, Tse CM, Chan G, Heinze ER, Nishimura RN, Weisbart RH. Intranuclear protein transduction through a nucleoside salvage pathway. J Biol Chem. 2007 Jul 20; 282(29):20790-3. PMID: 17525162.
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    41. Wasserman K, Sun XG, Hansen JE. Effect of biventricular pacing on the exercise pathophysiology of heart failure. Chest. 2007 Jul; 132(1):250-61. PMID: 17505041.
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    42. Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, Reeves ME. Antibody-mediated p53 protein therapy prevents liver metastasis in vivo. Cancer Res. 2007 Feb 15; 67(4):1769-74. PMID: 17308119.
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    43. Hansen JE, Sun XG, Wasserman K. Spirometric criteria for airway obstruction: Use percentage of FEV1/FVC ratio below the fifth percentile, not < 70%. Chest. 2007 Feb; 131(2):349-55. PMID: 17296632.
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    44. Hansen JE. A perspective on tuberculosis & exercise testing. Indian J Med Res. 2006 Oct; 124(4):383-4. PMID: 17159257.
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    45. Hansen JE, Sun XG, Wasserman K. Ethnic- and sex-free formulae for detection of airway obstruction. Am J Respir Crit Care Med. 2006 Sep 01; 174(5):493-8. PMID: 16778160.
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    46. Hansen JE, Sohn W, Kim C, Chang SS, Huang NC, Santos DG, Chan G, Weisbart RH, Nishimura RN. Antibody-mediated Hsp70 protein therapy. Brain Res. 2006 May 09; 1088(1):187-96. PMID: 16630585.
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    47. Hansen JE, Sun XG, Wasserman K. Discriminating measures and normal values for expiratory obstruction. Chest. 2006 Feb; 129(2):369-77. PMID: 16478854.
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    48. Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 2006 Feb; 9(2):234-42. PMID: 16415866.
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    49. Oudiz RJ, Barst RJ, Hansen JE, Sun XG, Garofano R, Wu X, Wasserman K. Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension. Am J Cardiol. 2006 Jan 01; 97(1):123-6. PMID: 16377296.
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    50. Hansen JE, Weisbart RH, Nishimura RN. Antibody mediated transduction of therapeutic proteins into living cells. ScientificWorldJournal. 2005 Sep 16; 5:782-8. PMID: 16170440.
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    51. Yasunobu Y, Oudiz RJ, Sun XG, Hansen JE, Wasserman K. End-tidal PCO2 abnormality and exercise limitation in patients with primary pulmonary hypertension. Chest. 2005 May; 127(5):1637-46. PMID: 15888840.
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    52. Weisbart RH, Hansen JE, Nishimura RN, Chan G, Wakelin R, Chang SS, Baresi L, Chamberlain JS. An intracellular delivery vehicle for protein transduction of micro-dystrophin. J Drug Target. 2005 Feb; 13(2):81-7. PMID: 15823959.
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    53. Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. Int J Oncol. 2004 Dec; 25(6):1867-73. PMID: 15547728.
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    54. Hansen JE, Sun XG, Yasunobu Y, Garafano RP, Gates G, Barst RJ, Wasserman K. Reproducibility of cardiopulmonary exercise measurements in patients with pulmonary arterial hypertension. Chest. 2004 Sep; 126(3):816-24. PMID: 15364761.
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    55. Sun XG, Hansen JE, Oudiz RJ, Wasserman K. Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol. 2003 Mar 19; 41(6):1028-35. PMID: 12651053.
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    56. Sun XG, Hansen JE, Garatachea N, Storer TW, Wasserman K. Ventilatory efficiency during exercise in healthy subjects. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1443-8. PMID: 12450934.
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    57. Chuang ML, Ting H, Otsuka T, Sun XG, Chiu FY, Hansen JE, Wasserman K. Muscle deoxygenation as related to work rate. Med Sci Sports Exerc. 2002 Oct; 34(10):1614-23. PMID: 12370563.
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    58. Hansen JE, Casaburi R. Mitochondrial disorders and exertional intolerance: controversy continues. Am J Respir Crit Care Med. 2002 Jul 01; 166(1):118; author reply 119-20. PMID: 12091181.
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    59. Hansen JE. Sarcoidosis and gas exchange measures. Chest. 2002 Mar; 121(3):1004-5. PMID: 11888995.
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    60. Sun XG, Hansen JE, Oudiz RJ, Wasserman K. Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Circulation. 2002 Jan 01; 105(1):54-60. PMID: 11772876.
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