Janos Porszasz

Title(s)Adjunct Professor, Medicine
SchoolMedicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identifying a Heart Rate Recovery Criterion After a 6-Minute Walk Test in COPD. Int J Chron Obstruct Pulmon Dis. 2021; 16:2545-2560. Zhao D, Abbasi A, Casaburi R, Adami A, Tiller NB, Yuan W, Yee C, Jendzjowsky NG, MacDonald DM, Kunisaki KM, Stringer WW, Porszasz J, Make BJ, Bowler RP, Rossiter HB, COPDGene Investigators . PMID: 34511898.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease. ERJ Open Res. 2021 Jul; 7(3). Balasubramanian A, Henderson RJ, Putcha N, Fawzy A, Raju S, Hansel NN, MacIntyre NR, Jensen RL, Kinney GL, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Make BJ, McCormack MC, Wise RA. PMID: 34322549.
      View in: PubMed   Mentions:
    3. Dynamic airway function during exercise in COPD assessed via impulse oscillometry before and after inhaled bronchodilators. J Appl Physiol (1985). 2021 07 01; 131(1):326-338. Tiller NB, Cao M, Lin F, Yuan W, Wang CY, Abbasi A, Calmelat R, Soriano A, Rossiter HB, Casaburi R, Stringer WW, Porszasz J. PMID: 34013748.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The effect of long-acting dual bronchodilator therapy on exercise tolerance, dynamic hyperinflation, and dead space during constant work rate exercise in COPD. J Appl Physiol (1985). 2021 06 01; 130(6):2009-2018. Stringer WW, Porszasz J, Cao M, Rossiter HB, Siddiqui S, Rennard S, Casaburi R. PMID: 33914661.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Transcutaneous PCO2 for Exercise Gas Exchange Efficiency in Chronic Obstructive Pulmonary Disease. COPD. 2021 02; 18(1):16-25. Cao M, Stringer WW, Corey S, Orogian A, Cao R, Calmelat R, Lin F, Casaburi R, Rossiter HB, Porszasz J. PMID: 33455452.
      View in: PubMed   Mentions: 1     Fields:    
    6. Airborne Particulate Concentrations During and After Pulmonary Function Testing. Chest. 2021 04; 159(4):1570-1574. Li J, Jing G, Fink JB, Porszasz J, Moran EM, Kiourkas RD, McLaughlin R, Vines DL, Dhand R. PMID: 33144080.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Muscle Oxidative Capacity Is Reduced in Both Upper and Lower Limbs in COPD. Med Sci Sports Exerc. 2020 10; 52(10):2061-2068. Adami A, Corvino RB, Calmelat RA, Porszasz J, Casaburi R, Rossiter HB. PMID: 32282451.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Response. Chest. 2020 10; 158(4):1781-1782. Morris TA, Porszasz J, Stringer WW. PMID: 33036092.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. A New Bronchodilator Response Grading Strategy Identifies Distinct Patient Populations. Ann Am Thorac Soc. 2019 12; 16(12):1504-1517. Hansen JE, Dilektasli AG, Porszasz J, Stringer WW, Pak Y, Rossiter HB, Casaburi R. PMID: 31404502.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. Dyspnea Postpulmonary Embolism From Physiological Dead Space Proportion and Stroke Volume Defects During Exercise. Chest. 2020 04; 157(4):936-944. Fernandes TM, Alotaibi M, Strozza DM, Stringer WW, Porszasz J, Faulkner GG, Castro CF, Tran DA, Morris TA. PMID: 31759962.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Diffusing Capacity of Carbon Monoxide in Assessment of COPD. Chest. 2019 12; 156(6):1111-1119. Balasubramanian A, MacIntyre NR, Henderson RJ, Jensen RL, Kinney G, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Barr RG, Make BJ, Wise RA, McCormack MC. PMID: 31352035.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. Physiologic Insights from the COPD Genetic Epidemiology Study. Chronic Obstr Pulm Dis. 2019 07 24; 6(3):256-266. Stringer WW, Porszasz J, Bhatt SP, McCormack MC, Make BJ, Casaburi R. PMID: 31342731.
      View in: PubMed   Mentions: 3  
    13. Physiologic Effects of Oxygen Supplementation During Exercise in Chronic Obstructive Pulmonary Disease. Clin Chest Med. 2019 06; 40(2):385-395. Dilektasli AG, Porszasz J, Stringer WW, Casaburi R. PMID: 31078216.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Oxygen Uptake and Lactate Kinetics in Patients with Chronic Obstructive Pulmonary Disease during Heavy Intensity Exercise: Role of Pedaling Cadence. COPD. 2018 06; 15(3):283-293. Pornsuriyasak P, Rambod M, Effros RM, Casaburi R, Porszasz J. PMID: 30156941.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Reliability and Physiological Interpretation of Pulmonary Gas Exchange by "Circulatory Equivalents" in Chronic Heart Failure. J Am Heart Assoc. 2018 03 27; 7(7). Tan C, Rossiter HB, Porszasz J, Bowen TS, Witte KK, Stringer WW, Casaburi R, Hansen JE. PMID: 29588313.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD. Respir Physiol Neurobiol. 2018 05; 251:8-15. Porszasz J, Carraro N, Cao R, Gore A, Ma S, Jiang T, Maltais F, Ferguson GT, O'Donnell DE, Shaikh A, Rossiter HB, Casaburi R. PMID: 29438808.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients. Chronic Dis Transl Med. 2016 Jun; 2(2):110-119. Li YN, Shapiro B, Kim JC, Zhang M, Porszasz J, Bross R, Feroze U, Upreti R, Martin D, Kalantar-Zadeh K, Kopple JD. PMID: 29063031.
      View in: PubMed   Mentions: 15  
    18. Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD. J Appl Physiol (1985). 2016 12 01; 121(6):1365-1373. Cannon DT, Coelho AC, Cao R, Cheng A, Porszasz J, Casaburi R, Rossiter HB. PMID: 27660300.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD. Respir Physiol Neurobiol. 2017 01; 235:18-26. Adami A, Cao R, Porszasz J, Casaburi R, Rossiter HB. PMID: 27659351.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    20. Relation of concavity in the expiratory flow-volume loop to dynamic hyperinflation during exercise in COPD. Respir Physiol Neurobiol. 2016 12; 234:79-84. Varga J, Casaburi R, Ma S, Hecht A, Hsia D, Somfay A, Porszasz J. PMID: 27575552.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria. Chest. 2016 Nov; 150(5):1080-1090. Dilektasli AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, Estepar RSJ, Hansen JE, COPDGene investigators . PMID: 27452770.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 07; 13(7):1016-25. Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J, Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL, COPDGene Investigators . PMID: 27158740.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    23. Patient Involvement in the Design of a Patient-Centered Clinical Trial to Promote Adherence to Supplemental Oxygen Therapy in COPD. Patient. 2016 06; 9(3):271-9. Holm KE, Casaburi R, Cerreta S, Gussin HA, Husbands J, Porszasz J, Prieto-Centurion V, Sandhaus RA, Sullivan JL, Walsh LJ, Krishnan JA. PMID: 26521057.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement. Eur Respir J. 2016 Feb; 47(2):429-60. Puente-Maestu L, Palange P, Casaburi R, Laveneziana P, Maltais F, Neder JA, O'Donnell DE, Onorati P, Porszasz J, Rabinovich R, Rossiter HB, Singh S, Troosters T, Ward S. PMID: 26797036.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    25. Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials. BMC Pulm Med. 2016 Jan 16; 16:13. Porszasz J, Blonshine S, Cao R, Paden HA, Casaburi R, Rossiter HB. PMID: 26775292.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Effect of Megestrol Acetate and Testosterone on Body Composition and Hormonal Responses in COPD Cachexia. Chronic Obstr Pulm Dis. 2015 Nov 09; 3(1):389-397. Casaburi R, Nakata J, Bistrong L, Torres E, Rambod M, Porszasz J. PMID: 28848861.
      View in: PubMed   Mentions: 2  
    27. Cluster Analysis in Patients with GOLD 1 Chronic Obstructive Pulmonary Disease. PLoS One. 2015; 10(4):e0123626. Gagnon P, Casaburi R, Saey D, Porszasz J, Provencher S, Milot J, Bourbeau J, O'Donnell DE, Maltais F. PMID: 25906326.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Re-Defining Lower Limit of Normal for FEV1/FEV6, FEV1/FVC, FEV3/FEV6 and FEV3/FVC to Improve Detection of Airway Obstruction. Chronic Obstr Pulm Dis. 2015 Mar 10; 2(2):94-102. Hansen JE, Porszasz J, Casaburi R, Stringer WW. PMID: 28848835.
      View in: PubMed   Mentions: 4  
    29. Factors affecting daily physical activity and physical performance in maintenance dialysis patients. J Ren Nutr. 2015 Mar; 25(2):217-22. Kopple JD, Kim JC, Shapiro BB, Zhang M, Li Y, Porszasz J, Bross R, Feroze U, Upreti R, Kalantar-Zadeh K. PMID: 25701942.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Effects of tiotropium on hyperinflation and treadmill exercise tolerance in mild to moderate chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014 Nov; 11(9):1351-61. Casaburi R, Maltais F, Porszasz J, Albers F, Deng Q, Iqbal A, Paden HA, O'Donnell DE, 205.440 Investigators . PMID: 25289942.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    31. An official European Respiratory Society statement on physical activity in COPD. Eur Respir J. 2014 Dec; 44(6):1521-37. Watz H, Pitta F, Rochester CL, Garcia-Aymerich J, ZuWallack R, Troosters T, Vaes AW, Puhan MA, Jehn M, Polkey MI, Vogiatzis I, Clini EM, Toth M, Gimeno-Santos E, Waschki B, Esteban C, Hayot M, Casaburi R, Porszasz J, McAuley E, Singh SJ, Langer D, Wouters EF, Magnussen H, Spruit MA. PMID: 25359358.
      View in: PubMed   Mentions: 115     Fields:    Translation:Humans
    32. Counterpoint: Is an increase in FEV₁ and/or FVC ≥ 12% of control and ≥ 200 mL the best way to assess positive bronchodilator response? No. Chest. 2014 Sep; 146(3):538-541. Hansen JE, Porszasz J. PMID: 25180718.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Rebuttal from Drs Hansen and Porszasz. Chest. 2014 Sep; 146(3):542-544. Hansen JE, Porszasz J. PMID: 25180720.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. The continuum of physiological impairment during treadmill walking in patients with mild-to-moderate COPD: patient characterization phase of a randomized clinical trial. PLoS One. 2014; 9(5):e96574. O'Donnell DE, Maltais F, Porszasz J, Webb KA, Albers FC, Deng Q, Iqbal A, Paden HA, Casaburi R, 205.440 investigators . PMID: 24788342.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Relation between anxiety, depression, and physical activity and performance in maintenance hemodialysis patients. J Ren Nutr. 2014 Jul; 24(4):252-60. Zhang M, Kim JC, Li Y, Shapiro BB, Porszasz J, Bross R, Feroze U, Upreti R, Martin D, Kalantar-Zadeh K, Kopple JD. PMID: 24788308.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    36. Selecting constant work rates for endurance testing in COPD: the role of the power-duration relationship. COPD. 2014 Jun; 11(3):267-76. van der Vaart H, Murgatroyd SR, Rossiter HB, Chen C, Casaburi R, Porszasz J. PMID: 24182350.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    37. Physiologic effects of an ambulatory ventilation system in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):334-42. Porszasz J, Cao R, Morishige R, van Eykern LA, Stenzler A, Casaburi R. PMID: 23741986.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Sinusoidal high-intensity exercise does not elicit ventilatory limitation in chronic obstructive pulmonary disease. Exp Physiol. 2013 Jun; 98(6):1102-14. Porszasz J, Rambod M, van der Vaart H, Rossiter HB, Ma S, Kiledjian R, Casaburi R. PMID: 23335005.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Comment on 'the effect of temperature on exhaled breath condensate collection'. J Breath Res. 2012 Dec; 6(4):048001; author reply 048002. Effros RM, Casaburi R, Porszasz J, Morales EM, Saraswat A, Rehan V. PMID: 23326824.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease. Clin Infect Dis. 2012 Sep; 55(5):e35-44. Dransfield MT, Harnden S, Burton RL, Albert RK, Bailey WC, Casaburi R, Connett J, Cooper JA, Criner GJ, Curtis JL, Han MK, Make B, Marchetti N, Martinez FJ, McEvoy C, Nahm MH, Niewoehner DE, Porszasz J, Reilly J, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Woodruff PG, Lazarus SC, NIH COPD Clinical Research Network . PMID: 22652582.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    41. Noninvasive assessment of normality of VD/VT in clinical cardiopulmonary exercise testing utilizing incremental cycle ergometry. Eur J Appl Physiol. 2013 Jan; 113(1):33-40. Roman MA, Casaburi JD, Porszasz J, Casaburi R. PMID: 22562602.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    42. Exhaled breath condensates: analyzing the expiratory plume. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):803-4. Effros RM, Casaburi R, Porszasz J, Morales EM, Rehan V. PMID: 22505753.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. COPD. 2012 Feb; 9(1):3-11. Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly JJ, Scanlon P, Scharf SM, Sciurba FC, Woodruff P, COPD Clinical Research Network . PMID: 22292592.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. Why conventional exhaled breath condensate pH studies cannot provide reliable estimates of airway acidification. Chest. 2011 Oct; 140(4):1099. Effros RM, Casaburi R, Porszasz J, Rehan V. PMID: 21972393.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr; 141(4):867-875. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R, COPDGene Investigators . PMID: 21960696.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    46. Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men. Respir Med. 2012 Feb; 106(2):269-75. Chavoshan B, Fournier M, Lewis MI, Porszasz J, Storer TW, Da X, Rambod M, Casaburi R. PMID: 21843929.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Assessment of exhaled breath condensate pH. Am J Respir Crit Care Med. 2011 Apr 01; 183(7):952; author reply 952-3. Effros RM, Casaburi R, Porszasz J, Rehan VK. PMID: 21471080.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD. Respir Med. 2011 Apr; 105(4):580-7. Maltais F, Celli B, Casaburi R, Porszasz J, Jarreta D, Seoane B, Caracta C. PMID: 21183326.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
    49. Clarifying the equation for modeling of VO2 kinetics above the lactate threshold. J Appl Physiol (1985). 2010 Oct; 109(4):1283-4. Ma S, Rossiter HB, Barstow TJ, Casaburi R, Porszasz J. PMID: 20940444.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    50. Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: a new method. Respir Med. 2010 Mar; 104(3):389-96. Ma S, Hecht A, Varga J, Rambod M, Morford S, Goto S, Casaburi R, Porszasz J. PMID: 19931441.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    51. Constant work rate exercise testing: a tricky measure of exercise tolerance. COPD. 2009 Oct; 6(5):317-9. Casaburi R, Porszasz J. PMID: 19863360.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    52. Methodology for using long-term accelerometry monitoring to describe daily activity patterns in COPD. COPD. 2009 Apr; 6(2):121-9. Hecht A, Ma S, Porszasz J, Casaburi R, COPD Clinical Research Network . PMID: 19378225.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    53. Indicator dilution measurements of extravascular lung water: basic assumptions and observations. . 2008 Jun; 294(6):L1023-31. Effros RM, Pornsuriyasak P, Porszasz J, Casaburi R. PMID: 18359882.
      View in: PubMed   Mentions: 13  Translation:Humans
    54. Supervised high intensity continuous and interval training vs. self-paced training in COPD. Respir Med. 2007 Nov; 101(11):2297-304. Varga J, Porszasz J, Boda K, Casaburi R, Somfay A. PMID: 17689948.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    55. Skeletal muscle adaptations to testosterone and resistance training in men with COPD. J Appl Physiol (1985). 2007 Oct; 103(4):1299-310. Lewis MI, Fournier M, Storer TW, Bhasin S, Porszasz J, Ren SG, Da X, Casaburi R. PMID: 17673568.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    56. Reduction of hyperinflation by pharmacologic and other interventions. Proc Am Thorac Soc. 2006 Apr; 3(2):185-9. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Casaburi R, Porszasz J. PMID: 16565430.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    57. Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest. 2005 Oct; 128(4):2025-34. Porszasz J, Emtner M, Goto S, Somfay A, Whipp BJ, Casaburi R. PMID: 16236851.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCTClinical Trials
    58. Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Oct 15; 170(8):870-8. Casaburi R, Bhasin S, Cosentino L, Porszasz J, Somfay A, Lewis MI, Fournier M, Storer TW. PMID: 15271690.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCTClinical Trials
    59. A treadmill ramp protocol using simultaneous changes in speed and grade. Med Sci Sports Exerc. 2003 Sep; 35(9):1596-603. Porszasz J, Casaburi R, Somfay A, Woodhouse LJ, Whipp BJ. PMID: 12972882.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCTClinical Trials
    60. Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1034-42. Emtner M, Porszasz J, Burns M, Somfay A, Casaburi R. PMID: 12869359.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCTClinical Trials