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Ardell, Jeffrey Laurence

Title(s)Professor-in-Residence, Medicine
SchoolCardiology
Phone50417
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    Other Positions
    Title(s)Professor-in-Residence, Anesthesiology


    Collapse Research 
    Collapse Research Activities and Funding
    Spinal Neuraxial Modulatin of Ventricular Excitability - Mechanisms and Therapeutics
    NIH/NHLBI R01HL136836Aug 1, 2018 - Jul 31, 2022
    Role: Co-Principal Investigator
    Bioelectric monitoring and control of the heart
    NIH/NIBIB U01EB025138Sep 26, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Distributed electrode system for high-fidelity cardio-neural mapping
    NIH/NIBIB U18EB021799Sep 1, 2017 - Jul 31, 2018
    Role: Principal Investigator
    Myocardial ischemia remodels the cardiac nervous system
    NIH/NHLBI R01HL071830Apr 5, 2005 - Mar 31, 2014
    Role: Principal Investigator
    INTRINSIC CARDIAC NEURONS AND CARDIAC CONTROL
    NIH/NHLBI R01HL058140Apr 1, 1997 - Mar 31, 2003
    Role: Principal Investigator
    REFLEX CONTROL OF CIRCULATION DURING EXERCISE
    NIH/NHLBI R23HL032392Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dale EA, Kipke J, Kubo Y, Sunshine MD, Castro PA, Ardell JL, Mahajan A. Spinal cord neural network interactions: implications for sympathetic control of the porcine heart. Am J Physiol Heart Circ Physiol. 2020 Apr 01; 318(4):H830-H839. PMID: 32108524.
      View in: PubMed
    2. Anand IS, Konstam MA, Klein HU, Mann DL, Ardell JL, Gregory DD, Massaro JM, Libbus I, DiCarlo LA, Udelson JJE, Butler J, Parker JD, Teerlink JR. Comparison of symptomatic and functional responses to vagus nerve stimulation in ANTHEM-HF, INOVATE-HF, and NECTAR-HF. ESC Heart Fail. 2020 Jan 27. PMID: 31984682.
      View in: PubMed
    3. Meijborg VMF, Boukens BJD, Janse MJ, Salavatian S, Dacey M, Yoshie K, Opthof T, Swid MA, Hoang JD, Hanna P, Ardell J, Shivkumar K, Coronel R. Stellate ganglion stimulation causes spatiotemporal changes of ventricular repolarization in pig. Heart Rhythm. 2020 Jan 06. PMID: 31917369.
      View in: PubMed
    4. Ardell JL, Foreman RD, Armour JA, Shivkumar K. Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during ischemia preventing ventricular fibrillation. JCI Insight. 2019 Dec 05; 4(23). PMID: 31671074.
      View in: PubMed
    5. Konstam MA, Udelson JE, Butler J, Klein HU, Parker JD, Teerlink JR, Wedge PM, Saville BR, Ardell JL, Libbus I, DiCarlo LA. Impact of Autonomic Regulation Therapy in Patients with Heart Failure: ANTHEM-HFrEF Pivotal Study Design. Circ Heart Fail. 2019 Nov; 12(11):e005879. PMID: 31722536.
      View in: PubMed
    6. Jungen C, Scherschel K, Flenner F, Jee H, Rajendran P, De Jong KA, Nikolaev V, Meyer C, Ardell JL, Tompkins JD. Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation. Am J Physiol Heart Circ Physiol. 2019 Dec 01; 317(6):H1328-H1341. PMID: 31625779.
      View in: PubMed
    7. Salavatian S, Ardell SM, Hammer M, Gibbons D, Armour JA, Ardell JL. Thoracic spinal cord neuromodulation obtunds dorsal root ganglion afferent neuronal transduction of the ischemic ventricle. Am J Physiol Heart Circ Physiol. 2019 Nov 01; 317(5):H1134-H1141. PMID: 31538809.
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    8. Premchand RK, Sharma K, Mittal S, Monteiro R, Libbus I, Ardell JL, Gregory DD, KenKnight BH, Amurthur B, DiCarlo LA, Anand IS. Background pharmacological therapy in the ANTHEM-HF: comparison to contemporary trials of novel heart failure therapies. ESC Heart Fail. 2019 Oct; 6(5):1052-1056. PMID: 31339232.
      View in: PubMed
    9. Salavatian S, Yamaguchi N, Hoang J, Lin N, Patel S, Ardell JL, Armour JA, Vaseghi M. Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 09 01; 317(3):H607-H616. PMID: 31322427.
      View in: PubMed
    10. Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, Deverman BE, Münzberg H, Ardell JL, Salama G, Gradinaru V, Shivkumar K. Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nat Commun. 2019 04 26; 10(1):1944. PMID: 31028266.
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    11. Horn CC, Ardell JL, Fisher LE. Electroceutical Targeting of the Autonomic Nervous System. Physiology (Bethesda). 2019 03 01; 34(2):150-162. PMID: 30724129.
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    12. Hanna P, Shivkumar K, Ardell JL. Calming the Nervous Heart: Autonomic Therapies in Heart Failure. Card Fail Rev. 2018 Aug; 4(2):92-98. PMID: 30206483.
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    13. Bardsley EN, Davis H, Ajijola OA, Buckler KJ, Ardell JL, Shivkumar K, Paterson DJ. RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity. Sci Rep. 2018 06 05; 8(1):8633. PMID: 29872217.
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    14. Liu K, Li D, Hao G, McCaffary D, Neely O, Woodward L, Ioannides D, Lu CJ, Brescia M, Zaccolo M, Tandri H, Ajijola OA, Ardell JL, Shivkumar K, Paterson DJ. Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity. JCI Insight. 2018 05 03; 3(9). PMID: 29720569.
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    15. Yoshie K, Rajendran PS, Massoud L, Kwon O, Tadimeti V, Salavatian S, Ardell JL, Shivkumar K, Ajijola OA. Cardiac vanilloid receptor-1 afferent depletion enhances stellate ganglion neuronal activity and efferent sympathetic response to cardiac stress. Am J Physiol Heart Circ Physiol. 2018 05 01; 314(5):H954-H966. PMID: 29351450.
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    16. DiCarlo LA, Libbus I, Kumar HU, Mittal S, Premchand RK, Amurthur B, KenKnight BH, Ardell JL, Anand IS. Autonomic regulation therapy to enhance myocardial function in heart failure patients: the ANTHEM-HFpEF study. ESC Heart Fail. 2018 02; 5(1):95-100. PMID: 29283224.
      View in: PubMed
    17. Ardell JL, Nier H, Hammer M, Southerland EM, Ardell CL, Beaumont E, KenKnight BH, Armour JA. Defining the neural fulcrum for chronic vagus nerve stimulation: implications for integrated cardiac control. J Physiol. 2017 11 15; 595(22):6887-6903. PMID: 28862330.
      View in: PubMed
    18. Ajijola OA, Hoover DB, Simerly TM, Brown TC, Yanagawa J, Biniwale RM, Lee JM, Sadeghi A, Khanlou N, Ardell JL, Shivkumar K. Inflammation, oxidative stress, and glial cell activation characterize stellate ganglia from humans with electrical storm. JCI Insight. 2017 09 21; 2(18). PMID: 28931760.
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    19. Shivkumar K, Ardell JL. Vagal Neuromodulation for Atrial Arrhythmias. JACC Clin Electrophysiol. 2017 09; 3(9):939-941. PMID: 29759718.
      View in: PubMed
    20. Salavatian S, Beaumont E, Gibbons D, Hammer M, Hoover DB, Armour JA, Ardell JL. Thoracic spinal cord and cervical vagosympathetic neuromodulation obtund nodose sensory transduction of myocardial ischemia. Auton Neurosci. 2017 12; 208:57-65. PMID: 28919363.
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    21. Kember G, Ardell JL, Shivkumar K, Armour JA. Recurrent myocardial infarction: Mechanisms of free-floating adaptation and autonomic derangement in networked cardiac neural control. PLoS One. 2017; 12(7):e0180194. PMID: 28692680.
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    22. Chui RW, Buckley U, Rajendran PS, Vrabec T, Shivkumar K, Ardell JL. Bioelectronic block of paravertebral sympathetic nerves mitigates post-myocardial infarction ventricular arrhythmias. Heart Rhythm. 2017 11; 14(11):1665-1672. PMID: 28629852.
      View in: PubMed
    23. Ardell JL, Shivkumar K. Sympathetic neural recording-It is all in the details. Heart Rhythm. 2017 07; 14(7):972-973. PMID: 28438720.
      View in: PubMed
    24. Hamon D, Rajendran PS, Chui RW, Ajijola OA, Irie T, Talebi R, Salavatian S, Vaseghi M, Bradfield JS, Armour JA, Ardell JL, Shivkumar K. Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping. Circ Arrhythm Electrophysiol. 2017 Apr; 10(4). PMID: 28408652.
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    25. Buckley U, Chui RW, Rajendran PS, Vrabec T, Shivkumar K, Ardell JL. Bioelectronic neuromodulation of the paravertebral cardiac efferent sympathetic outflow and its effect on ventricular electrical indices. Heart Rhythm. 2017 07; 14(7):1063-1070. PMID: 28219848.
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    26. Ajijola OA, Lux RL, Khahera A, Kwon O, Aliotta E, Ennis DB, Fishbein MC, Ardell JL, Shivkumar K. Sympathetic modulation of electrical activation in normal and infarcted myocardium: implications for arrhythmogenesis. Am J Physiol Heart Circ Physiol. 2017 Mar 01; 312(3):H608-H621. PMID: 28087519.
      View in: PubMed
    27. Ardell JL, Armour JA. Neurocardiology: Structure-Based Function. Compr Physiol. 2016 09 15; 6(4):1635-1653. PMID: 27783854.
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    28. Salavatian S, Beaumont E, Longpré JP, Armour JA, Vinet A, Jacquemet V, Shivkumar K, Ardell JL. Vagal stimulation targets select populations of intrinsic cardiac neurons to control neurally induced atrial fibrillation. Am J Physiol Heart Circ Physiol. 2016 11 01; 311(5):H1311-H1320. PMID: 27591222.
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    29. Shivkumar K, Ardell JL. Cardiac autonomic control in health and disease. J Physiol. 2016 07 15; 594(14):3851-2. PMID: 27417670.
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    30. Ardell JL, Andresen MC, Armour JA, Billman GE, Chen PS, Foreman RD, Herring N, O'Leary DS, Sabbah HN, Schultz HD, Sunagawa K, Zucker IH. Translational neurocardiology: preclinical models and cardioneural integrative aspects. J Physiol. 2016 07 15; 594(14):3877-909. PMID: 27098459.
      View in: PubMed
    31. Nakamura K, Ajijola OA, Aliotta E, Armour JA, Ardell JL, Shivkumar K. Pathological effects of chronic myocardial infarction on peripheral neurons mediating cardiac neurotransmission. Auton Neurosci. 2016 05; 197:34-40. PMID: 27209472.
      View in: PubMed
    32. Beaumont E, Wright GL, Southerland EM, Li Y, Chui R, KenKnight BH, Armour JA, Ardell JL. Vagus nerve stimulation mitigates intrinsic cardiac neuronal remodeling and cardiac hypertrophy induced by chronic pressure overload in guinea pig. Am J Physiol Heart Circ Physiol. 2016 May 15; 310(10):H1349-59. PMID: 26993230.
      View in: PubMed
    33. Ardell JL. Heart failure: Mechanisms of spinal cord neuromodulation for heart disease. Nat Rev Cardiol. 2016 Mar; 13(3):127-8. PMID: 26843288.
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    34. Rajendran PS, Nakamura K, Ajijola OA, Vaseghi M, Armour JA, Ardell JL, Shivkumar K. Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system. J Physiol. 2016 Jan 15; 594(2):321-41. PMID: 26572244.
      View in: PubMed
    35. Yamakawa K, Howard-Quijano K, Zhou W, Rajendran P, Yagishita D, Vaseghi M, Ajijola OA, Armour JA, Shivkumar K, Ardell JL, Mahajan A. Central vs. peripheral neuraxial sympathetic control of porcine ventricular electrophysiology. Am J Physiol Regul Integr Comp Physiol. 2016 Mar 01; 310(5):R414-21. PMID: 26661096.
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    36. Premchand RK, Sharma K, Mittal S, Monteiro R, Dixit S, Libbus I, DiCarlo LA, Ardell JL, Rector TS, Amurthur B, KenKnight BH, Anand IS. Extended Follow-Up of Patients With Heart Failure Receiving Autonomic Regulation Therapy in the ANTHEM-HF Study. J Card Fail. 2016 Aug; 22(8):639-42. PMID: 26576716.
      View in: PubMed
    37. Ardell JL, Rajendran PS, Nier HA, KenKnight BH, Armour JA. Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function. Am J Physiol Heart Circ Physiol. 2015 Nov 15; 309(10):H1740-52. PMID: 26371171.
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    38. Beaumont E, Southerland EM, Hardwick JC, Wright GL, Ryan S, Li Y, KenKnight BH, Armour JA, Ardell JL. Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction. Am J Physiol Heart Circ Physiol. 2015 Oct; 309(7):H1198-206. PMID: 26276818.
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    39. Buckley U, Yamakawa K, Takamiya T, Andrew Armour J, Shivkumar K, Ardell JL. Targeted stellate decentralization: Implications for sympathetic control of ventricular electrophysiology. Heart Rhythm. 2016 Jan; 13(1):282-8. PMID: 26282244.
      View in: PubMed
    40. Buckley U, Shivkumar K, Ardell JL. Autonomic Regulation Therapy in Heart Failure. Curr Heart Fail Rep. 2015 Aug; 12(4):284-93. PMID: 26054327.
      View in: PubMed
    41. Fukuda K, Kanazawa H, Aizawa Y, Ardell JL, Shivkumar K. Cardiac innervation and sudden cardiac death. Circ Res. 2015 Jun 05; 116(12):2005-19. PMID: 26044253.
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    42. Hardwick JC, Ryan SE, Powers EN, Southerland EM, Ardell JL. Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 15; 309(2):R179-88. PMID: 25947168.
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    43. Ajijola OA, Yagishita D, Reddy NK, Yamakawa K, Vaseghi M, Downs AM, Hoover DB, Ardell JL, Shivkumar K. Remodeling of stellate ganglion neurons after spatially targeted myocardial infarction: Neuropeptide and morphologic changes. Heart Rhythm. 2015 May; 12(5):1027-35. PMID: 25640636.
      View in: PubMed
    44. Kember G, Ardell JL, Armour JA, Zamir M. Vagal nerve stimulation therapy: what is being stimulated? PLoS One. 2014; 9(12):e114498. PMID: 25479368.
      View in: PubMed
    45. Ardell JL, Cardinal R, Beaumont E, Vermeulen M, Smith FM, Andrew Armour J. Chronic spinal cord stimulation modifies intrinsic cardiac synaptic efficacy in the suppression of atrial fibrillation. Auton Neurosci. 2014 Dec; 186:38-44. PMID: 25301713.
      View in: PubMed
    46. Premchand RK, Sharma K, Mittal S, Monteiro R, Dixit S, Libbus I, DiCarlo LA, Ardell JL, Rector TS, Amurthur B, KenKnight BH, Anand IS. Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: results of the ANTHEM-HF trial. J Card Fail. 2014 Nov; 20(11):808-16. PMID: 25187002.
      View in: PubMed
    47. Longpré JP, Salavatian S, Beaumont E, Armour JA, Ardell JL, Jacquemet V. Measure of synchrony in the activity of intrinsic cardiac neurons. Physiol Meas. 2014 Apr; 35(4):549-66. PMID: 24621585.
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    48. Hardwick JC, Ryan SE, Beaumont E, Ardell JL, Southerland EM. Dynamic remodeling of the guinea pig intrinsic cardiac plexus induced by chronic myocardial infarction. Auton Neurosci. 2014 Apr; 181:4-12. PMID: 24220238.
      View in: PubMed
    49. Beaumont E, Salavatian S, Southerland EM, Vinet A, Jacquemet V, Armour JA, Ardell JL. Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function. J Physiol. 2013 Sep 15; 591(18):4515-33. PMID: 23818689.
      View in: PubMed
    50. Hardwick JC, Southerland EM, Girasole AE, Ryan SE, Negrotto S, Ardell JL. Remodeling of intrinsic cardiac neurons: effects of ß-adrenergic receptor blockade in guinea pig models of chronic heart disease. Am J Physiol Regul Integr Comp Physiol. 2012 Nov 01; 303(9):R950-8. PMID: 22933026.
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    51. Southerland EM, Gibbons DD, Smith SB, Sipe A, Williams CA, Beaumont E, Armour JA, Foreman RD, Ardell JL. Activated cranial cervical cord neurons affect left ventricular infarct size and the potential for sudden cardiac death. Auton Neurosci. 2012 Jul 02; 169(1):34-42. PMID: 22502863.
      View in: PubMed
    52. Gibbons DD, Southerland EM, Hoover DB, Beaumont E, Armour JA, Ardell JL. Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 01; 302(3):R357-64. PMID: 22088304.
      View in: PubMed
    53. Girasole AE, Palmer CP, Corrado SL, Marie Southerland E, Ardell JL, Hardwick JC. Angiotensin II potentiates adrenergic and muscarinic modulation of guinea pig intracardiac neurons. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1391-9. PMID: 21865545.
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    54. Ardell JL. The cardiac neuronal hierarchy and susceptibility to arrhythmias. Heart Rhythm. 2011 Apr; 8(4):590-1. PMID: 21167959.
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    55. Ardell JL. Sensory transduction of the ischemic myocardium. Am J Physiol Heart Circ Physiol. 2010 Dec; 299(6):H1753-4. PMID: 20952672.
      View in: PubMed
    56. Hardwick JC, Baran CN, Southerland EM, Ardell JL. Remodeling of the guinea pig intrinsic cardiac plexus with chronic pressure overload. Am J Physiol Regul Integr Comp Physiol. 2009 Sep; 297(3):R859-66. PMID: 19605763.
      View in: PubMed
    57. Ardell JL, Cardinal R, Vermeulen M, Armour JA. Dorsal spinal cord stimulation obtunds the capacity of intrathoracic extracardiac neurons to transduce myocardial ischemia. Am J Physiol Regul Integr Comp Physiol. 2009 Aug; 297(2):R470-7. PMID: 19515981.
      View in: PubMed
    58. Cardinal R, Pagé P, Vermeulen M, Ardell JL, Armour JA. Spatially divergent cardiac responses to nicotinic stimulation of ganglionated plexus neurons in the canine heart. Auton Neurosci. 2009 Jan 28; 145(1-2):55-62. PMID: 19071069.
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    59. Hardwick JC, Southerland EM, Ardell JL. Chronic myocardial infarction induces phenotypic and functional remodeling in the guinea pig cardiac plexus. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1926-33. PMID: 18832084.
      View in: PubMed
    60. Ding X, Hua F, Sutherly K, Ardell JL, Williams CA. C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons. Am J Physiol Regul Integr Comp Physiol. 2008 Nov; 295(5):R1519-28. PMID: 18753268.
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    61. Richer LP, Vinet A, Kus T, Cardinal R, Ardell JL, Armour JA. Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol. 2008 Oct; 295(4):R1175-80. PMID: 18716036.
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    62. Hoover DB, Shepherd AV, Southerland EM, Armour JA, Ardell JL. Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium. Auton Neurosci. 2008 Aug 18; 141(1-2):38-45. PMID: 18558516.
      View in: PubMed
    63. Ding X, Ardell JL, Hua F, McAuley RJ, Sutherly K, Daniel JJ, Williams CA. Modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive C2 spinal cord stimulation: effect on substance P release from rat spinal cord. Am J Physiol Regul Integr Comp Physiol. 2008 Jan; 294(1):R93-101. PMID: 17989135.
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    64. Tompkins JD, Ardell JL, Hoover DB, Parsons RL. Neurally released pituitary adenylate cyclase-activating polypeptide enhances guinea pig intrinsic cardiac neurone excitability. J Physiol. 2007 Jul 01; 582(Pt 1):87-93. PMID: 17495034.
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    65. Southerland EM, Milhorn DM, Foreman RD, Linderoth B, DeJongste MJ, Armour JA, Subramanian V, Singh M, Singh K, Ardell JL. Preemptive, but not reactive, spinal cord stimulation mitigates transient ischemia-induced myocardial infarction via cardiac adrenergic neurons. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H311-7. PMID: 16920800.
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    66. Hankes GH, Ardell JL, Tallaj J, Wei CC, Aban I, Holland M, Rynders P, Dillon R, Cardinal R, Hoover DB, Armour JA, Husain A, Dell'Italia LJ. Beta1-adrenoceptor blockade mitigates excessive norepinephrine release into cardiac interstitium in mitral regurgitation in dog. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H147-51. PMID: 16772522.
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    67. Cardinal R, Pagé P, Vermeulen M, Bouchard C, Ardell JL, Foreman RD, Armour JA. Spinal cord stimulation suppresses bradycardias and atrial tachyarrhythmias induced by mediastinal nerve stimulation in dogs. Am J Physiol Regul Integr Comp Physiol. 2006 Nov; 291(5):R1369-75. PMID: 16778070.
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    68. Waldmann M, Thompson GW, Kember GC, Ardell JL, Armour JA. Stochastic behavior of atrial and ventricular intrinsic cardiac neurons. J Appl Physiol (1985). 2006 Aug; 101(2):413-9. PMID: 16645188.
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    69. Katori T, Hoover DB, Ardell JL, Helm RH, Belardi DF, Tocchetti CG, Forfia PR, Kass DA, Paolocci N. Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failure. Circ Res. 2005 Feb 04; 96(2):234-43. PMID: 15591228.
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    70. Hua F, Ardell JL, Williams CA. Left vagal stimulation induces dynorphin release and suppresses substance P release from the rat thoracic spinal cord during cardiac ischemia. Am J Physiol Regul Integr Comp Physiol. 2004 Dec; 287(6):R1468-77. PMID: 15297264.
      View in: PubMed
    71. Killingsworth CR, Wei CC, Dell'Italia LJ, Ardell JL, Kingsley MA, Smith WM, Ideker RE, Walcott GP. Short-acting beta-adrenergic antagonist esmolol given at reperfusion improves survival after prolonged ventricular fibrillation. Circulation. 2004 May 25; 109(20):2469-74. PMID: 15123529.
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    72. Cardinal R, Ardell JL, Linderoth B, Vermeulen M, Foreman RD, Armour JA. Spinal cord activation differentially modulates ischaemic electrical responses to different stressors in canine ventricles. Auton Neurosci. 2004 Mar 31; 111(1):37-47. PMID: 15109937.
      View in: PubMed
    73. Gray AL, Johnson TA, Ardell JL, Massari VJ. Parasympathetic control of the heart. II. A novel interganglionic intrinsic cardiac circuit mediates neural control of heart rate. J Appl Physiol (1985). 2004 Jun; 96(6):2273-8. PMID: 14978001.
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    74. Gray AL, Johnson TA, Lauenstein JM, Newton SS, Ardell JL, Massari VJ. Parasympathetic control of the heart. III. Neuropeptide Y-immunoreactive nerve terminals synapse on three populations of negative chronotropic vagal preganglionic neurons. J Appl Physiol (1985). 2004 Jun; 96(6):2279-87. PMID: 14978003.
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    75. Hua F, Ricketts BA, Reifsteck A, Ardell JL, Williams CA. Myocardial ischemia induces the release of substance P from cardiac afferent neurons in rat thoracic spinal cord. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1654-64. PMID: 14684370.
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    76. Arora RC, Cardinal R, Smith FM, Ardell JL, Dell'Italia LJ, Armour JA. Intrinsic cardiac nervous system in tachycardia induced heart failure. Am J Physiol Regul Integr Comp Physiol. 2003 Nov; 285(5):R1212-23. PMID: 12893651.
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    77. Tallaj J, Wei CC, Hankes GH, Holland M, Rynders P, Dillon AR, Ardell JL, Armour JA, Lucchesi PA, Dell'Italia LJ. Beta1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation. Circulation. 2003 Jul 15; 108(2):225-30. PMID: 12847066.
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    78. Randall DC, Brown DR, McGuirt AS, Thompson GW, Armour JA, Ardell JL. Interactions within the intrinsic cardiac nervous system contribute to chronotropic regulation. Am J Physiol Regul Integr Comp Physiol. 2003 Nov; 285(5):R1066-75. PMID: 12842863.
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    79. Armour JA, Linderoth B, Arora RC, DeJongste MJ, Ardell JL, Kingma JG, Hill M, Foreman RD. Long-term modulation of the intrinsic cardiac nervous system by spinal cord neurons in normal and ischaemic hearts. Auton Neurosci. 2002 Jan 10; 95(1-2):71-9. PMID: 11873770.
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    80. Smith FM, McGuirt AS, Leger J, Armour JA, Ardell JL. Effects of chronic cardiac decentralization on functional properties of canine intracardiac neurons in vitro. Am J Physiol Regul Integr Comp Physiol. 2001 Nov; 281(5):R1474-82. PMID: 11641118.
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    81. Smith FM, McGuirt AS, Hoover DB, Armour JA, Ardell JL. Chronic decentralization of the heart differentially remodels canine intrinsic cardiac neuron muscarinic receptors. Am J Physiol Heart Circ Physiol. 2001 Nov; 281(5):H1919-30. PMID: 11668052.
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    82. Kingma JG, Linderoth B, Ardell JL, Armour JA, DeJongste MJ, Foreman RD. Neuromodulation therapy does not influence blood flow distribution or left-ventricular dynamics during acute myocardial ischemia. Auton Neurosci. 2001 Aug 13; 91(1-2):47-54. PMID: 11515801.
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    83. Farrell DM, Wei CC, Tallaj J, Ardell JL, Armour JA, Hageman GR, Bradley WE, Dell'Italia LJ. Angiotensin II modulates catecholamine release into interstitial fluid of canine myocardium in vivo. Am J Physiol Heart Circ Physiol. 2001 Aug; 281(2):H813-22. PMID: 11454586.
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    84. Thompson GW, Collier K, Ardell JL, Kember G, Armour JA. Functional interdependence of neurons in a single canine intrinsic cardiac ganglionated plexus. J Physiol. 2000 Nov 01; 528(Pt 3):561-71. PMID: 11060132.
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    85. Dyess DL, Collins JN, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. Modulation of microvascular permeability by 21-aminosteroids after burn injuries. J Burn Care Rehabil. 2000 Sep-Oct; 21(5):406-13. PMID: 11020047.
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    86. Foreman RD, Linderoth B, Ardell JL, Barron KW, Chandler MJ, Hull SS, TerHorst GJ, DeJongste MJ, Armour JA. Modulation of intrinsic cardiac neurons by spinal cord stimulation: implications for its therapeutic use in angina pectoris. Cardiovasc Res. 2000 Aug; 47(2):367-75. PMID: 10946073.
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    87. Murphy DA, Thompson GW, Ardell JL, McCraty R, Stevenson RS, Sangalang VE, Cardinal R, Wilkinson M, Craig S, Smith FM, Kingma JG, Armour JA. The heart reinnervates after transplantation. Ann Thorac Surg. 2000 Jun; 69(6):1769-81. PMID: 10892922.
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    88. Powell RW, Dyess DL, Collins JN, Roberts WS, Tacchi EJ, Swafford AN, Ferrara JJ, Ardell JL. Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets. J Pediatr Surg. 1999 Jan; 34(1):193-8. PMID: 10022170.
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    89. Dyess DL, Christenberry DP, Peeples GL, Collins JN, Ardell JL, Roberts WS, Tacchi EJ, Powell RW. Organ blood flow redistribution in response to hypoxemia in neonatal piglets. J Invest Surg. 1998 Nov-Dec; 11(6):381-92. PMID: 9895112.
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    90. Thompson GW, Hoover DB, Ardell JL, Armour JA. Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors. Am J Physiol. 1998 11; 275(5):R1683-9. PMID: 9791091.
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    91. Randall DC, Brown DR, Li SG, Olmstead ME, Kilgore JM, Sprinkle AG, Randall WC, Ardell JL. Ablation of posterior atrial ganglionated plexus potentiates sympathetic tachycardia to behavioral stress. Am J Physiol. 1998 09; 275(3):R779-87. PMID: 9728075.
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    92. Armour JA, Collier K, Kember G, Ardell JL. Differential selectivity of cardiac neurons in separate intrathoracic autonomic ganglia. Am J Physiol. 1998 04; 274(4):R939-49. PMID: 9575954.
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    93. Parker JC, Cave CB, Ardell JL, Hamm CR, Williams SG. Vascular tree structure affects lung blood flow heterogeneity simulated in three dimensions. J Appl Physiol (1985). 1997 Oct; 83(4):1370-82. PMID: 9338448.
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    94. McGuirt AS, Schmacht DC, Ardell JL. Autonomic interactions for control of atrial rate are maintained after SA nodal parasympathectomy. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2525-33. PMID: 9227527.
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    95. Levett JM, Murphy DA, McGuirt AS, Ardell JL, Armour JA. Cardiac augmentation can be maintained by continuous exposure of intrinsic cardiac neurons to a beta-adrenergic agonist or angiotensin II. J Surg Res. 1996 Dec; 66(2):167-73. PMID: 9024830.
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    96. Ardell JL, Yang XM, Barron BA, Downey JM, Cohen MV. Endogenous myocardial norepinephrine is not essential for ischemic preconditioning in rabbit heart. Am J Physiol. 1996 Mar; 270(3 Pt 2):H1078-84. PMID: 8780206.
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    97. Goto M, Liu Y, Yang XM, Ardell JL, Cohen MV, Downey JM. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res. 1995 Sep; 77(3):611-21. PMID: 7641331.
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    98. Dyess DL, Powell RW, Roberts WS, Tacchi EJ, Swafford AN, Ferrara JJ, Ardell JL. Regional blood flow redistribution in preterm piglets with hemorrhage and resuscitation. J Surg Res. 1995 Jul; 59(1):29-34. PMID: 7630133.
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    99. Ferrara JJ, Dyess DL, Peeples GL, Christenberry DP, Roberts WS, Tacchi EJ, Swafford AN, Ardell JL, Powell RW. Effects of dopamine and dobutamine on regional blood flow distribution in the neonatal piglet. Ann Surg. 1995 May; 221(5):531-40; discussion 540-2. PMID: 7748035.
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    100. Parker JC, Ardell JL, Hamm CR, Barman SA, Coker PJ. Regional pulmonary blood flow during rest, tilt, and exercise in unanesthetized dogs. J Appl Physiol (1985). 1995 Mar; 78(3):838-46. PMID: 7775327.
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    101. Barman SA, Ardell JL, Taylor AE. Effect of phorbol myristate acetate-induced lung injury on airway blood flow. Respir Physiol. 1995 Feb; 99(2):249-57. PMID: 7777708.
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    102. Ferrara JJ, Dyess DL, Collins JN, Fish JM, Markert AJ, Ardell JL, Townsley MI, Flint LM, Taylor AE. Effects of graded thermal injury on microvascular permeability at the site of injury. J Surg Res. 1994 Sep; 57(3):420-6. PMID: 8072291.
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    103. Dyess DL, Powell RW, Swafford AN, Schmacht DC, Roberts WS, Ferrara JJ, Ardell JL. Redistribution of organ blood flow after hemorrhage and resuscitation in full-term piglets. J Pediatr Surg. 1994 Aug; 29(8):1097-102. PMID: 7525918.
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    104. Townsley MI, Pitts VH, Ardell JL, Zhao Z, Johnson WH. Altered pulmonary microvascular reactivity to norepinephrine in canine pacing-induced heart failure. Circ Res. 1994 Aug; 75(2):347-56. PMID: 7518365.
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    105. Dyess DL, Tacchi E, Powell RQ, Ardell JL, Roberts WS, Ferrara JJ. Development of a protocol to provide prolonged general anesthesia to pregnant sows. J Invest Surg. 1994 May-Jun; 7(3):235-42. PMID: 7918245.
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    106. Yuan BX, Ardell JL, Hopkins DA, Losier AM, Armour JA. Gross and microscopic anatomy of the canine intrinsic cardiac nervous system. Anat Rec. 1994 May; 239(1):75-87. PMID: 8037379.
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    107. Ferrara JJ, Dyess DL, Collins JN, Fish JM, Ardell JL, Townsley MI, Taylor AE, Flint LM. Effects of pentafraction administration on microvascular permeability alterations induced by graded thermal injury. Surgery. 1994 Feb; 115(2):182-9. PMID: 7508639.
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    108. Tasdemiroglu E, Christenberry PD, Ardell JL, Chronister RB, Taylor AE. Effects of antioxidants on the blood-brain barrier and postischemic hyperemia. Acta Neurochir (Wien). 1994; 131(3-4):302-9. PMID: 7754839.
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    109. Collins JN, Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. The effects of albumin administration on microvascular permeability at the site of burn injury. J Trauma. 1994 Jan; 36(1):27-33. PMID: 8295246.
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    110. Barman SA, Ardell JL, Taylor AE. Effects of left atrial and airway pressures on airway blood flow. Respir Physiol. 1993 Oct; 94(1):61-74. PMID: 8272582.
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    111. Dyess DL, Peeples GL, Ardell JL, Tacchi EJ, Roberts WS, Ferrara JJ, Powell RW. Indomethacin-induced blood flow distribution in premature and full-term piglets. J Pediatr Surg. 1993 Oct; 28(10):1396-400. PMID: 8263708.
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    112. Yuan BX, Ardell JL, Hopkins DA, Armour JA. Differential cardiac responses induced by nicotine sensitive canine atrial and ventricular neurones. Cardiovasc Res. 1993 May; 27(5):760-9. PMID: 8348576.
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    113. Tasdemiroglu E, Chistenberry PD, Ardell JL, Chronister RB, Taylor AE. Effect of superoxide dismutase on acute reperfusion injury of the rabbit brain. Acta Neurochir (Wien). 1993; 120(3-4):180-6. PMID: 8460572.
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    114. Huang MH, Ardell JL, Hanna BD, Wolf SG, Armour JA. Effects of transient coronary artery occlusion on canine intrinsic cardiac neuronal activity. Integr Physiol Behav Sci. 1993 Jan-Mar; 28(1):5-21. PMID: 8476742.
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    115. Barman SA, Ardell JL, Taylor AE. Effect of endothelin-1 on canine airway blood flow. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S274-7. PMID: 7509964.
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    116. Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. Effects of hypertonic saline and dextran 70 resuscitation on microvascular permeability after burn. Am J Physiol. 1992 Jun; 262(6 Pt 2):H1832-7. PMID: 1377878.
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    117. Ardell JL, Butler CK, Smith FM, Hopkins DA, Armour JA. Activity of in vivo atrial and ventricular neurons in chronically decentralized canine hearts. Am J Physiol. 1991 Mar; 260(3 Pt 2):H713-21. PMID: 2000967.
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    118. Ardell JL, Randall WC, Pomeroy G, Lawton M, Kim T. Autonomic regulation of subsidiary atrial pacemakers during exercise. J Appl Physiol (1985). 1991 Mar; 70(3):1175-83. PMID: 2032983.
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    119. Townsley MI, Negrini D, Ardell JL. Regional blood flow to canine parietal pleura and internal intercostal muscle. J Appl Physiol (1985). 1991 Jan; 70(1):97-102. PMID: 2010416.
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    120. Barman AA, Moideen AS, Chaudhry SS, Ardell J, Barman SA, Cantu R. Nerve-sparing dissection as alternative to anesthesia of carotid sinus nerve in preparation for carotid endarterectomy. Tex Heart Inst J. 1989; 16(2):107-9. PMID: 15227222.
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    121. Ardell JL, Randall WC, Cannon WJ, Schmacht DC, Tasdemiroglu E. Differential sympathetic regulation of automatic, conductile, and contractile tissue in dog heart. Am J Physiol. 1988 Nov; 255(5 Pt 2):H1050-9. PMID: 3189569.
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    122. Barman SA, Ardell JL, Parker JC, Perry ML, Taylor AE. Pulmonary and systemic blood flow contributions to upper airways in canine lung. Am J Physiol. 1988 Nov; 255(5 Pt 2):H1130-5. PMID: 3189574.
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    123. Randall WC, Ardell JL, O'Toole MF, Wurster RD. Differential autonomic control of SAN and AVN regions of the canine heart: structure and function. Prog Clin Biol Res. 1988; 275:15-31. PMID: 3051007.
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    124. Fee JD, Randall WC, Wurster RD, Ardell JL. Selective ganglionic blockade of vagal inputs to sinoatrial and/or atrioventricular regions. J Pharmacol Exp Ther. 1987 Sep; 242(3):1006-12. PMID: 2888868.
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    125. Randall WC, Ardell JL, Wurster RD, Milosavljevic M. Vagal postganglionic innervation of the canine sinoatrial node. J Auton Nerv Syst. 1987 Jul; 20(1):13-23. PMID: 3655182.
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    126. Ardell JL, Randall WC. Selective vagal innervation of sinoatrial and atrioventricular nodes in canine heart. Am J Physiol. 1986 Oct; 251(4 Pt 2):H764-73. PMID: 3021001.
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    127. Pomeroy G, Ardell JL, Wurster RD. Spinal opiate modulation of cardiovascular reflexes in the exercising dog. Brain Res. 1986 Sep 03; 381(2):385-9. PMID: 3019479.
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    128. O'Toole MF, Ardell JL, Randall WC. Functional interdependence of discrete vagal projections to SA and AV nodes. Am J Physiol. 1986 Aug; 251(2 Pt 2):H398-404. PMID: 3017130.
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    129. Randall WC, Ardell JL, Calderwood D, Milosavljevic M, Goyal SC. Parasympathetic ganglia innervating the canine atrioventricular nodal region. J Auton Nerv Syst. 1986 Aug; 16(4):311-23. PMID: 3745782.
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    130. Randall WC, Milosavljevic M, Wurster RD, Geis GS, Ardell JL. Selective vagal innervation of the heart. Ann Clin Lab Sci. 1986 May-Jun; 16(3):198-208. PMID: 2872849.
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    131. Kim KS, Ardell JL, Randall WC, Pomeroy G, Calderwood D. Cardiac responses to exercise in the dog before and after destruction of the sinoatrial node. Eur J Appl Physiol Occup Physiol. 1986; 55(3):253-8. PMID: 2874023.
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    132. Randall WC, Ardell JL, Becker DM. Differential responses accompanying sequential stimulation and ablation of vagal branches to dog heart. Am J Physiol. 1985 Jul; 249(1 Pt 2):H133-40. PMID: 4014479.
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    133. Randall WC, Ardell JL. Selective parasympathectomy of automatic and conductile tissues of the canine heart. Am J Physiol. 1985 Jan; 248(1 Pt 2):H61-8. PMID: 3970176.
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    134. Wyss CR, Ardell JL, Scher AM, Rowell LB. Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs. Am J Physiol. 1983 Sep; 245(3):H481-6. PMID: 6614196.
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    135. Ardell JL, Barman SM, Gebber GL. Sympathetic nerve discharge in chronic spinal cat. Am J Physiol. 1982 Sep; 243(3):H463-70. PMID: 7114277.
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