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Alger Jeffry

Title(s)Professor, Neurology
Phone310-206-3344
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    Collapse Research 
    Collapse Research Activities and Funding
    VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
    NIH/NIBIB R01EB002087Sep 25, 2000 - Jun 30, 2006
    Role: Principal Investigator
    VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
    NIH/NINDS R01NS039498Sep 25, 2000 - Jun 30, 2004
    Role: Principal Investigator
    RESEARCH ANIMAL MAGNETIC RESONANCE IMAGING INSTRUMENT
    NIH/NCRR S10RR013065May 15, 1999 - Sep 30, 2003
    Role: Principal Investigator
    PEDIATRIC LOW GRADE ASTROCYTOMA--TREATMENT GUIDANCE
    NIH/NCI R21CA076524Dec 12, 1997 - Nov 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Levitt JG, Kalender G, O’Neill J, Diaz JP, Cook IA, Ginder N, Krantz D, Minzenberg MJ, Vince-Cruz N, Nguyen LD, Alger JR, Leuchter AF. Dorsolateral prefrontal ?-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy J Psychiatry Neurosci. 2019 Nov 01; 44(6):386-394. PMID: 31199104.
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    2. Nir TM, Jahanshad N, Ching CRK, Cohen RA, Harezlak J, Schifitto G, Lam HY, Hua X, Zhong J, Zhu T, Taylor MJ, Campbell TB, Daar ES, Singer EJ, Alger JR, Thompson PM, Navia BA. Progressive brain atrophy in chronically infected and treated HIV+ individuals. J Neurovirol. 2019 Jun; 25(3):342-353. PMID: 30767174.
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    3. Tang J, O'Neill J, Alger JR, Shen Z, Johnson MC, London ED. N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users. Int J Neuropsychopharmacol. 2019 01 01; 22(1):1-9. PMID: 29788422.
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    4. Babikian T, Alger JR, Ellis-Blied MU, Giza CC, Dennis E, Olsen A, Mink R, Babbitt C, Johnson J, Thompson PM, Asarnow RF. Whole Brain Magnetic Resonance Spectroscopic Determinants of Functional Outcomes in Pediatric Moderate/Severe Traumatic Brain Injury. J Neurotrauma. 2018 07 15; 35(14):1637-1645. PMID: 29649959.
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    5. Dennis EL, Babikian T, Alger J, Rashid F, Villalon-Reina JE, Jin Y, Olsen A, Mink R, Babbitt C, Johnson J, Giza CC, Thompson PM, Asarnow RF. Magnetic resonance spectroscopy of fiber tracts in children with traumatic brain injury: A combined MRS - Diffusion MRI study. Hum Brain Mapp. 2018 09; 39(9):3759-3768. PMID: 29749094.
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    6. Alger JR, Sherry AD, Malloy CR. tcaSIM: A Simulation Program for Optimal Design of 13C Tracer Experiments for Analysis of Metabolic Flux by NMR and Mass Spectroscopy. Curr Metabolomics. 2018; 6(3):176-187. PMID: 31745452.
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    7. Martin T, Hoffman J, Alger JR, McNitt-Gray M, Wang DJ. Low-dose CT perfusion with projection view sharing. Med Phys. 2018 Jan; 45(1):101-113. PMID: 29080274.
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    8. O'Neill J, Piacentini J, Chang S, Ly R, Lai TM, Armstrong CC, Bergman L, Rozenman M, Peris T, Vreeland A, Mudgway R, Levitt JG, Salamon N, Posse S, Hellemann GS, Alger JR, McCracken JT, Nurmi EL. Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial. Neuropsychopharmacology. 2017 Nov; 42(12):2414-2422. PMID: 28409563.
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    9. Dai Y, Zhao Y, Tomi M, Shin BC, Thamotharan S, Mazarati A, Sankar R, Wang EA, Cepeda C, Levine MS, Zhang J, Frew A, Alger JR, Clark PM, Sondhi M, Kositamongkol S, Leibovitch L, Devaskar SU. Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability. Endocrinology. 2017 04 01; 158(4):936-949. PMID: 28324109.
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    10. Bajwa N, Sung S, Ennis DB, Fishbein MC, Nowroozi BN, Ruan D, Maccabi A, Alger J, John MAS, Grundfest WS, Taylor ZD. Terahertz Imaging of Cutaneous Edema: Correlation With Magnetic Resonance Imaging in Burn Wounds. IEEE Trans Biomed Eng. 2017 11; 64(11):2682-2694. PMID: 28141514.
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    11. Martin RM, Wright MJ, Lutkenhoff ES, Ellingson BM, Van Horn JD, Tubi M, Alger JR, McArthur DL, Vespa PM. Traumatic hemorrhagic brain injury: impact of location and resorption on cognitive outcome. J Neurosurg. 2017 Mar; 126(3):796-804. PMID: 27231979.
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    12. O'Neill J, Lai TM, Sheen C, Salgari GC, Ly R, Armstrong C, Chang S, Levitt JG, Salamon N, Alger JR, Feusner JD. Cingulate and thalamic metabolites in obsessive-compulsive disorder. Psychiatry Res Neuroimaging. 2016 Aug 30; 254:34-40. PMID: 27317876.
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    13. Alger JR, Ellingson BM, Ashe-McNalley C, Woodworth DC, Labus JS, Farmer M, Huang L, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Deutsch G, Harris RE, Clauw DJ, Glover GH, Parrish TB, Hollander Jd, Kusek JW, Mullins C, Mayer EA. Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network. Neuroimage Clin. 2016; 12:65-77. PMID: 27408791.
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    14. Feusner JD, Moody T, Lai TM, Sheen C, Khalsa S, Brown J, Levitt J, Alger J, O'Neill J. Brain connectivity and prediction of relapse after cognitive-behavioral therapy in obsessive-compulsive disorder. Front Psychiatry. 2015; 6:74. PMID: 26042054.
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    15. Anderson AM, Harezlak J, Bharti A, Mi D, Taylor MJ, Daar ES, Schifitto G, Zhong J, Alger JR, Brown MS, Singer EJ, Campbell TB, McMahon DD, Buchthal S, Cohen R, Yiannoutsos C, Letendre SL, Navia BA. Plasma and Cerebrospinal Fluid Biomarkers Predict Cerebral Injury in HIV-Infected Individuals on Stable Combination Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2015 May 01; 69(1):29-35. PMID: 25622053.
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    16. Yu S, Liebeskind DS, Dua S, Wilhalme H, Elashoff D, Qiao XJ, Alger JR, Sanossian N, Starkman S, Ali LK, Scalzo F, Lou X, Yoo B, Saver JL, Salamon N, Wang DJ. Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke. J Cereb Blood Flow Metab. 2015 Mar 31; 35(4):630-7. PMID: 25564233.
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    17. Apostolova LG, Zarow C, Biado K, Hurtz S, Boccardi M, Somme J, Honarpisheh H, Blanken AE, Brook J, Tung S, Lo D, Ng D, Alger JR, Vinters HV, Bocchetta M, Duvernoy H, Jack CR, Frisoni GB. Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol. Alzheimers Dement. 2015 Feb; 11(2):139-50. PMID: 25620800.
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    18. Sabati M, Sheriff S, Gu M, Wei J, Zhu H, Barker PB, Spielman DM, Alger JR, Maudsley AA. Multivendor implementation and comparison of volumetric whole-brain echo-planar MR spectroscopic imaging. Magn Reson Med. 2015 Nov; 74(5):1209-20. PMID: 25354190.
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    19. Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkác I, Vigneron DB, Kauppinen RA. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014 Mar; 270(3):658-79. PMID: 24568703.
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    20. Wang R, Yu S, Alger JR, Zuo Z, Chen J, Wang R, An J, Wang B, Zhao J, Xue R, Wang DJ. Multi-delay arterial spin labeling perfusion MRI in moyamoya disease--comparison with CT perfusion imaging. Eur Radiol. 2014 May; 24(5):1135-44. PMID: 24557051.
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    21. Huo J, Okada K, van Rikxoort EM, Kim HJ, Alger JR, Pope WB, Goldin JG, Brown MS. Ensemble segmentation for GBM brain tumors on MR images using confidence-based averaging. Med Phys. 2013 Sep; 40(9):093502. PMID: 24007185.
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    22. Wright MJ, McArthur DL, Alger JR, Van Horn J, Irimia A, Filippou M, Glenn TC, Hovda DA, Vespa P. Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury. Brain Imaging Behav. 2013 Sep; 7(3):307-15. PMID: 23636971.
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    23. Hua X, Boyle CP, Harezlak J, Tate DF, Yiannoutsos CT, Cohen R, Schifitto G, Gongvatana A, Zhong J, Zhu T, Taylor MJ, Campbell TB, Daar ES, Alger JR, Singer E, Buchthal S, Toga AW, Navia B, Thompson PM. Disrupted cerebral metabolite levels and lower nadir CD4 + counts are linked to brain volume deficits in 210 HIV-infected patients on stable treatment. Neuroimage Clin. 2013; 3:132-42. PMID: 24179857.
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    24. Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC, Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ. Acute Stroke Imaging Research Roadmap II. Stroke. 2013 Sep; 44(9):2628-39. PMID: 23860298.
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    25. Wang DJ, Alger JR, Qiao JX, Gunther M, Pope WB, Saver JL, Salamon N, Liebeskind DS. Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke - Comparison with dynamic susceptibility contrast enhanced perfusion imaging. Neuroimage Clin. 2013; 3:1-7. PMID: 24159561.
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    26. Torgerson CM, Irimia A, Leow AD, Bartzokis G, Moody TD, Jennings RG, Alger JR, Van Horn JD, Altshuler LL. DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects. Brain Imaging Behav. 2013 Jun; 7(2):129-39. PMID: 23070746.
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    27. Scalzo F, Alger JR, Hu X, Saver JL, Dani KA, Muir KW, Demchuk AM, Coutts SB, Luby M, Warach S, Liebeskind DS. Multi-center prediction of hemorrhagic transformation in acute ischemic stroke using permeability imaging features. Magn Reson Imaging. 2013 Jul; 31(6):961-9. PMID: 23587928.
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    28. Lawrence KE, Levitt JG, Loo SK, Ly R, Yee V, O'Neill J, Alger J, Narr KL. White matter microstructure in subjects with attention-deficit/hyperactivity disorder and their siblings. J Am Acad Child Adolesc Psychiatry. 2013 Apr; 52(4):431-440.e4. PMID: 23582873.
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    29. Kidwell CS, Jahan R, Gornbein J, Alger JR, Nenov V, Ajani Z, Feng L, Meyer BC, Olson S, Schwamm LH, Yoo AJ, Marshall RS, Meyers PM, Yavagal DR, Wintermark M, Guzy J, Starkman S, Saver JL. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013 Mar 07; 368(10):914-23. PMID: 23394476.
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    30. Roy B, Gupta RK, Maudsley AA, Awasthi R, Sheriff S, Gu M, Husain N, Mohakud S, Behari S, Pandey CM, Rathore RK, Spielman DM, Alger JR. Utility of multiparametric 3-T MRI for glioma characterization. Neuroradiology. 2013 May; 55(5):603-13. PMID: 23377234.
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    31. Tafazoli S, O'Neill J, Bejjani A, Ly R, Salamon N, McCracken JT, Alger JR, Levitt JG. 1H MRSI of middle frontal gyrus in pediatric ADHD. J Psychiatr Res. 2013 Apr; 47(4):505-12. PMID: 23273650.
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    32. Kidwell CS, Wintermark M, De Silva DA, Schaewe TJ, Jahan R, Starkman S, Jovin T, Hom J, Jumaa M, Schreier J, Gornbein J, Liebeskind DS, Alger JR, Saver JL. Multiparametric MRI and CT models of infarct core and favorable penumbral imaging patterns in acute ischemic stroke. Stroke. 2013 Jan; 44(1):73-9. PMID: 23233383.
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    33. Posse S, Otazo R, Dager SR, Alger J. MR spectroscopic imaging: principles and recent advances. J Magn Reson Imaging. 2013 Jun; 37(6):1301-25. PMID: 23188775.
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    34. Goodkin K, Alger JR, Maudsley AA, Govind V, Sheriff S, Zhang JM. Clinical utility of magnetic resonance spectroscopy to enhance diagnosis of HIV-associated mild neurocognitive disorder. Neuropsychiatry (London). 2012 Oct 01; 2(5):379-383. PMID: 23682297.
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    35. Bartzokis G, Lu PH, Heydari P, Couvrette A, Lee GJ, Kalashyan G, Freeman F, Grinstead JW, Villablanca P, Finn JP, Mintz J, Alger JR, Altshuler LL. Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals. Biol Psychiatry. 2012 Dec 15; 72(12):1026-34. PMID: 23017471.
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    36. Kidwell CS, Jahan R, Alger JR, Schaewe TJ, Guzy J, Starkman S, Elashoff R, Gornbein J, Nenov V, Saver JL. Design and rationale of the Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) Trial. Int J Stroke. 2014 Jan; 9(1):110-6. PMID: 22974139.
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    37. Bejjani A, O'Neill J, Kim JA, Frew AJ, Yee VW, Ly R, Kitchen C, Salamon N, McCracken JT, Toga AW, Alger JR, Levitt JG. Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI. PLoS One. 2012; 7(7):e38786. PMID: 22848344.
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    38. Alger JR. The diffusion tensor imaging toolbox. J Neurosci. 2012 May 30; 32(22):7418-28. PMID: 22649222.
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    39. Scalzo F, Hao Q, Alger JR, Hu X, Liebeskind DS. Regional prediction of tissue fate in acute ischemic stroke. Ann Biomed Eng. 2012 Oct; 40(10):2177-87. PMID: 22592291.
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    40. Wang DJ, Alger JR, Qiao JX, Hao Q, Hou S, Fiaz R, Gunther M, Pope WB, Saver JL, Salamon N, Liebeskind DS. The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced MRI. Stroke. 2012 Apr; 43(4):1018-24. PMID: 22328551.
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    41. Irimia A, Chambers MC, Torgerson CM, Filippou M, Hovda DA, Alger JR, Gerig G, Toga AW, Vespa PM, Kikinis R, Van Horn JD. Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. Front Neurol. 2012; 3:10. PMID: 22363313.
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    42. MacKenzie-Graham A, Rinek GA, Avedisian A, Gold SM, Frew AJ, Aguilar C, Lin DR, Umeda E, Voskuhl RR, Alger JR. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. Neuroimage. 2012 Mar; 60(1):95-104. PMID: 22182769.
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    43. Lee M, Saver JL, Alger JR, Hao Q, Salamon N, Starkman S, Ali LK, Ovbiagele B, Kim D, Villablanca JP, Froehler MT, Tenser MS, Liebeskind DS. Association of laterality and size of perfusion lesions on neurological deficit in acute supratentorial stroke. Int J Stroke. 2012 Jun; 7(4):293-7. PMID: 22151911.
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    44. Hua X, Thompson PM, Leow AD, Madsen SK, Caplan R, Alger JR, O'Neill J, Joshi K, Smalley SL, Toga AW, Levitt JG. Brain growth rate abnormalities visualized in adolescents with autism. Hum Brain Mapp. 2013 Feb; 34(2):425-36. PMID: 22021093.
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    45. O'Neill J, Piacentini JC, Chang S, Levitt JG, Rozenman M, Bergman L, Salamon N, Alger JR, McCracken JT. MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10; 36(1):161-8. PMID: 21983143.
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    46. Lee M, Saver JL, Alger JR, Hao Q, Starkman S, Ali LK, Kim D, Ovbiagele B, Vespa PM, Froehler MT, Tenser MS, Salamon N, Villablanca JP, Jahan R, Duckwiler GR, Tateshima S, Gonzalez N, Vinuela F, Liebeskind DS. Blood-brain barrier permeability derangements in posterior circulation ischemic stroke: frequency and relation to hemorrhagic transformation. J Neurol Sci. 2012 Feb 15; 313(1-2):142-6. PMID: 21945462.
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    47. Irimia A, Chambers MC, Alger JR, Filippou M, Prastawa MW, Wang B, Hovda DA, Gerig G, Toga AW, Kikinis R, Vespa PM, Van Horn JD. Comparison of acute and chronic traumatic brain injury using semi-automatic multimodal segmentation of MR volumes. J Neurotrauma. 2011 Nov; 28(11):2287-306. PMID: 21787171.
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    48. Kurth F, Narr KL, Woods RP, O'Neill J, Alger JR, Caplan R, McCracken JT, Toga AW, Levitt JG. Diminished gray matter within the hypothalamus in autism disorder: a potential link to hormonal effects? Biol Psychiatry. 2011 Aug 01; 70(3):278-82. PMID: 21531390.
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    49. Clark KA, Nuechterlein KH, Asarnow RF, Hamilton LS, Phillips OR, Hageman NS, Woods RP, Alger JR, Toga AW, Narr KL. Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia. J Psychiatr Res. 2011 Jul; 45(7):980-8. PMID: 21306734.
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    50. Lemaire JJ, Frew AJ, McArthur D, Gorgulho AA, Alger JR, Salomon N, Chen C, Behnke EJ, De Salles AA. White matter connectivity of human hypothalamus. Brain Res. 2011 Jan 31; 1371:43-64. PMID: 21122799.
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    51. Sanossian N, Ovbiagele B, Saver JL, Alger JR, Starkman S, Kim D, Ohanian AG, Buck BH, Ali LK, Duckwiler GR, Jahan R, Viñuela F, Liebeskind DS. Leukoaraiosis and collaterals in acute ischemic stroke. J Neuroimaging. 2011 Jul; 21(3):232-5. PMID: 20977524.
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    52. Alger JR. Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: a didactic review. Top Magn Reson Imaging. 2010 Apr; 21(2):115-28. PMID: 21613876.
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    53. Babikian T, Marion SD, Copeland S, Alger JR, O'Neill J, Cazalis F, Mink R, Giza CC, Vu JA, Hilleary SM, Kernan CL, Newman N, Asarnow RF. Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI. J Neurotrauma. 2010 Mar; 27(3):473-81. PMID: 19925210.
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    54. Xu Y, McArthur DL, Alger JR, Etchepare M, Hovda DA, Glenn TC, Huang S, Dinov I, Vespa PM. Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury. J Cereb Blood Flow Metab. 2010 Apr; 30(4):883-94. PMID: 20029449.
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    55. Bang OY, Saver JL, Lee KH, Kim GM, Chung CS, Kim SJ, Ovbiagele B, Alger JR, Liebeskind DS. Characteristics of patients with target magnetic resonance mismatch profile: data from two geographically and racially distinct populations. Cerebrovasc Dis. 2010; 29(1):87-94. PMID: 19907169.
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    56. Pope WB, Kim HJ, Huo J, Alger J, Brown MS, Gjertson D, Sai V, Young JR, Tekchandani L, Cloughesy T, Mischel PS, Lai A, Nghiemphu P, Rahmanuddin S, Goldin J. Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009 Jul; 252(1):182-9. PMID: 19561256.
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    57. Kim SJ, Seok JM, Bang OY, Kim GM, Kim KH, Jeon P, Chung CS, Lee KH, Alger JR, Liebeskind DS. MR mismatch profiles in patients with intracranial atherosclerotic stroke: a comprehensive approach comparing stroke subtypes. J Cereb Blood Flow Metab. 2009 Jun; 29(6):1138-45. PMID: 19367294.
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    58. Kidwell CS, Lees KR, Muir KW, Chen C, Davis SM, De Silva DA, Weir CJ, Starkman S, Alger JR, Saver JL. Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial. Stroke. 2009 May; 40(5):1704-9. PMID: 19299636.
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    59. Alger JR, Schaewe TJ, Lai TC, Frew AJ, Vespa PM, Etchepare M, Liebeskind DS, Saver JL, Kidwell SC. Contrast agent dose effects in cerebral dynamic susceptibility contrast magnetic resonance perfusion imaging. J Magn Reson Imaging. 2009 Jan; 29(1):52-64. PMID: 19097106.
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    60. Bang OY, Saver JL, Alger JR, Shah SH, Buck BH, Starkman S, Ovbiagele B, Liebeskind DS. Patterns and predictors of blood-brain barrier permeability derangements in acute ischemic stroke. Stroke. 2009 Feb; 40(2):454-61. PMID: 19038915.
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    61. Hamilton LS, Levitt JG, O'Neill J, Alger JR, Luders E, Phillips OR, Caplan R, Toga AW, McCracken J, Narr KL. Reduced white matter integrity in attention-deficit hyperactivity disorder. Neuroreport. 2008 Nov 19; 19(17):1705-8. PMID: 18841089.
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    62. Bang OY, Liebeskind DS, Buck BH, Yoon SR, Alger JR, Ovbiagele B, Saver JL. Impact of reperfusion after 3 hours of symptom onset on tissue fate in acute cerebral ischemia. J Neuroimaging. 2009 Oct; 19(4):317-22. PMID: 19021836.
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    63. Marcoux J, McArthur DA, Miller C, Glenn TC, Villablanca P, Martin NA, Hovda DA, Alger JR, Vespa PM. Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury. Crit Care Med. 2008 Oct; 36(10):2871-7. PMID: 18766106.
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    64. Kumar R, Macey PM, Woo MA, Alger JR, Harper RM. Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatr Res. 2008 Sep; 64(3):275-80. PMID: 18458651.
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    65. Cross RL, Kumar R, Macey PM, Doering LV, Alger JR, Yan-Go FL, Harper RM. Neural alterations and depressive symptoms in obstructive sleep apnea patients. Sleep. 2008 Aug; 31(8):1103-9. PMID: 18714782.
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    66. Burgess RE, Warach S, Schaewe TJ, Copenhaver BR, Alger JR, Vespa P, Martin N, Saver JL, Kidwell CS. Development and validation of a simple conversion model for comparison of intracerebral hemorrhage volumes measured on CT and gradient recalled echo MRI. Stroke. 2008 Jul; 39(7):2017-20. PMID: 18483414.
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    67. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. AJNR Am J Neuroradiol. 2008 May; 29(5):e23-30. PMID: 18477656.
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    68. Miller CM, Vespa P, Saver JL, Kidwell CS, Carmichael ST, Alger J, Frazee J, Starkman S, Liebeskind D, Nenov V, Elashoff R, Martin N. Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage. Surg Neurol. 2008 May; 69(5):441-6; discussion 446. PMID: 18424298.
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    69. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. Stroke. 2008 May; 39(5):1621-8. PMID: 18403743.
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    70. Kidwell CS, Latour L, Saver JL, Alger JR, Starkman S, Duckwiler G, Jahan R, Vinuela F, Kang DW, Warach S. Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke. Cerebrovasc Dis. 2008; 25(4):338-43. PMID: 18303253.
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    71. Posse S, Otazo R, Caprihan A, Bustillo J, Chen H, Henry PG, Marjanska M, Gasparovic C, Zuo C, Magnotta V, Mueller B, Mullins P, Renshaw P, Ugurbil K, Lim KO, Alger JR. Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Magn Reson Med. 2007 Aug; 58(2):236-44. PMID: 17610279.
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    72. Bang OY, Buck BH, Saver JL, Alger JR, Yoon SR, Starkman S, Ovbiagele B, Kim D, Ali LK, Sanossian N, Jahan R, Duckwiler GR, Viñuela F, Salamon N, Villablanca JP, Liebeskind DS. Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol. 2007 Aug; 62(2):170-6. PMID: 17683090.
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    73. Hebb MO, McArthur DL, Alger J, Etchepare M, Glenn TC, Bergsneider M, Martin N, Vespa PM. Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury. J Neurotrauma. 2007 Apr; 24(4):579-90. PMID: 17439342.
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    74. Kumar R, Macey PM, Woo MA, Alger JR, Harper RM. Elevated mean diffusivity in widespread brain regions in congenital central hypoventilation syndrome. J Magn Reson Imaging. 2006 Dec; 24(6):1252-8. PMID: 17075838.
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    75. Ovbiagele B, Saver JL, Sanossian N, Salamon N, Villablanca P, Alger JR, Razinia T, Kim D, Liebeskind DS. Predictors of cerebral microbleeds in acute ischemic stroke and TIA patients. Cerebrovasc Dis. 2006; 22(5-6):378-83. PMID: 16888379.
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    76. Wu GN, Ford JM, Alger JR. MRI measurement of the uptake and retention of motexafin gadolinium in glioblastoma multiforme and uninvolved normal human brain. J Neurooncol. 2006 Mar; 77(1):95-103. PMID: 16547607.
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    77. Kumar R, Macey PM, Woo MA, Alger JR, Keens TG, Harper RM. Neuroanatomic deficits in congenital central hypoventilation syndrome. J Comp Neurol. 2005 Jul 11; 487(4):361-71. PMID: 15906312.
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    78. Macey KE, Macey PM, Woo MA, Henderson LA, Frysinger RC, Harper RK, Alger JR, Yan-Go F, Harper RM. Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea. Respir Physiol Neurobiol. 2006 Mar 28; 151(1):44-60. PMID: 15993658.
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    79. Kidwell CS, Chalela JA, Saver JL, Starkman S, Hill MD, Demchuk AM, Butman JA, Patronas N, Alger JR, Latour LL, Luby ML, Baird AE, Leary MC, Tremwel M, Ovbiagele B, Fredieu A, Suzuki S, Villablanca JP, Davis S, Dunn B, Todd JW, Ezzeddine MA, Haymore J, Lynch JK, Davis L, Warach S. Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA. 2004 Oct 20; 292(15):1823-30. PMID: 15494579.
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    80. Kidwell CS, Alger JR, Saver JL. Evolving paradigms in neuroimaging of the ischemic penumbra. Stroke. 2004 Nov; 35(11 Suppl 1):2662-5. PMID: 15472112.
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    81. Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rüb U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC. Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science. 2004 Jun 04; 304(5676):1509-13. PMID: 15105459.
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    82. Vespa P, McArthur DL, Alger J, O'Phelan K, Hattori N, Wu C, Glenn T, Bergsneider M, Martin NA, Hovda DA. Regional heterogeneity of post-traumatic brain metabolism as studied by microdialysis, magnetic resonance spectroscopy and positron emission tomography. Brain Pathol. 2004 Apr; 14(2):210-4. PMID: 15193034.
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    83. O'Neill J, Levitt J, Caplan R, Asarnow R, McCracken JT, Toga AW, Alger JR. 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia. Neuroimage. 2004 Apr; 21(4):1781-9. PMID: 15050598.
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    84. Kumar A, Gupta RC, Albert Thomas M, Alger J, Wyckoff N, Hwang S. Biophysical changes in normal-appearing white matter and subcortical nuclei in late-life major depression detected using magnetization transfer. Psychiatry Res. 2004 Feb 15; 130(2):131-40. PMID: 15033183.
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    85. Ostrem JL, Saver JL, Alger JR, Starkman S, Leary MC, Duckwiler G, Jahan R, Vespa P, Villablanca JP, Gobin YP, Vinuela F, Kidwell CS. Acute basilar artery occlusion: diffusion-perfusion MRI characterization of tissue salvage in patients receiving intra-arterial stroke therapies. Stroke. 2004 Feb; 35(2):e30-4. PMID: 14739412.
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    86. Fiehler J, Knudsen K, Kucinski T, Kidwell CS, Alger JR, Thomalla G, Eckert B, Wittkugel O, Weiller C, Zeumer H, Röther J. Predictors of apparent diffusion coefficient normalization in stroke patients. Stroke. 2004 Feb; 35(2):514-9. PMID: 14739409.
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    87. Macey PM, Alger JR, Kumar R, Macey KE, Woo MA, Harper RM. Global BOLD MRI changes to ventilatory challenges in congenital central hypoventilation syndrome. Respir Physiol Neurobiol. 2003 Dec 16; 139(1):41-50. PMID: 14637309.
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    88. Wyckoff N, Kumar A, Gupta RC, Alger J, Hwang S, Thomas MA. Magnetization transfer imaging and magnetic resonance spectroscopy of normal-appearing white matter in late-life major depression. J Magn Reson Imaging. 2003 Nov; 18(5):537-43. PMID: 14579396.
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    89. Kidwell CS, Alger JR, Saver JL. Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke. 2003 Nov; 34(11):2729-35. PMID: 14576370.
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    90. Shih LC, Saver JL, Alger JR, Starkman S, Leary MC, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Villablanca JP, Vespa PM, Kidwell CS. Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke. 2003 Jun; 34(6):1425-30. PMID: 12738899.
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    91. Chu A, Alger JR, Moore GJ, Posse S. Proton echo-planar spectroscopic imaging with highly effective outer volume suppression using combined presaturation and spatially selective echo dephasing. Magn Reson Med. 2003 May; 49(5):817-21. PMID: 12704763.
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    92. Harper RM, Macey PM, Henderson LA, Woo MA, Macey KE, Frysinger RC, Alger JR, Nguyen KP, Yan-Go FL. fMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects. J Appl Physiol (1985). 2003 Apr; 94(4):1583-95. PMID: 12514164.
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    93. Henderson LA, Macey PM, Macey KE, Frysinger RC, Woo MA, Harper RK, Alger JR, Yan-Go FL, Harper RM. Brain responses associated with the Valsalva maneuver revealed by functional magnetic resonance imaging. J Neurophysiol. 2002 Dec; 88(6):3477-86. PMID: 12466462.
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    94. Kidwell CS, Saver JL, Starkman S, Duckwiler G, Jahan R, Vespa P, Villablanca JP, Liebeskind DS, Gobin YP, Vinuela F, Alger JR. Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann Neurol. 2002 Dec; 52(6):698-703. PMID: 12447922.
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    95. Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, Harper RK, Yan-Go FL, Harper RM. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med. 2002 Nov 15; 166(10):1382-7. PMID: 12421746.
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    96. Henderson LA, Woo MA, Macey PM, Macey KE, Frysinger RC, Alger JR, Yan-Go F, Harper RM. Neural responses during Valsalva maneuvers in obstructive sleep apnea syndrome. J Appl Physiol (1985). 2003 Mar; 94(3):1063-74. PMID: 12433858.
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    97. Alger JR, Frew AJ, Cloughesy TF, Del Vecchio W, Villablanca JP, Curran JG. Novel methodology for the archiving and interactive reading of clinical magnetic resonance spectroscopic imaging. Magn Reson Med. 2002 Sep; 48(3):411-8. PMID: 12210904.
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    98. Kidwell CS, Saver JL, Villablanca JP, Duckwiler G, Fredieu A, Gough K, Leary MC, Starkman S, Gobin YP, Jahan R, Vespa P, Liebeskind DS, Alger JR, Vinuela F. Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke. 2002 Jan; 33(1):95-8. PMID: 11779895.
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    99. Alger JR, Harreld JH, Chen S, Mintorovitch J, Lu DS. Time-to-echo optimization for spin echo magnetic resonance imaging of liver metastasis using superparamagnetic iron oxide particles. J Magn Reson Imaging. 2001 Nov; 14(5):586-94. PMID: 11747011.
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