Loading...

Kaunitz, Jonathan D

Title(s)Professor-in-Residence, Medicine
Phone310-268-3879
vCardDownload vCard
    Other Positions
    Title(s)Professor-in-Residence, Surgery


    Collapse Research 
    Collapse Research Activities and Funding
    Luminal Factors Affecting Duodenal Protection and Chemosensing
    VA I01BX001245Jul 1, 2012 - Jun 30, 2021
    Role: Principal Investigator
    An in vitro system for the study of epithelial bicarbonate secretion
    NIH/NIDDK R21DK081199Jun 1, 2009 - May 31, 2012
    Role: Principal Investigator
    Duodenal Mucosal Defense Mechanisms
    NIH/NIDDK R01DK054221May 1, 1999 - Sep 29, 2007
    Role: Principal Investigator
    COLONIC PROTON PUMP--ROLE IN ELECTROLYTE ABSORPTION
    NIH/NIDDK R01DK039162Sep 18, 1987 - Jun 30, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kaunitz JD, Akiba Y. Correction to: Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too. Dig Dis Sci. 2020 Feb; 65(2):669. PMID: 31823102.
      View in: PubMed
    2. Kaunitz JD. Oral Defense: How Oral Rehydration Solutions Revolutionized the Treatment of Toxigenic Diarrhea. Dig Dis Sci. 2020 Feb; 65(2):345-348. PMID: 31900719.
      View in: PubMed
    3. Maruta K, Takajo T, Akiba Y, Said H, Irie E, Kato I, Kuwahara A, Kaunitz JD. GLP-2 Acutely Prevents Endotoxin-Related Increased Intestinal Paracellular Permeability in Rats. Dig Dis Sci. 2020 Jan 31. PMID: 32006214.
      View in: PubMed
    4. Fenton RA, Murali SK, Kaji I, Akiba Y, Kaunitz JD, Kristensen TB, Poulsen SB, Dominguez Rieg JA, Rieg T. Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea. J Infect Dis. 2019 Oct 22; 220(11):1719-1728. PMID: 30624615.
      View in: PubMed
    5. Kaunitz JD, Akiba Y. Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too. Dig Dis Sci. 2019 Oct; 64(10):2709-2716. PMID: 31435858.
      View in: PubMed
    6. Iwasaki M, Akiba Y, Kaunitz JD. Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. F1000Res. 2019; 8. PMID: 31559013.
      View in: PubMed
    7. Matthis AL, Kaji I, Engevik KA, Akiba Y, Kaunitz JD, Montrose MH, Aihara E. Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage. Dig Dis Sci. 2020 Jan; 65(1):119-131. PMID: 31515722.
      View in: PubMed
    8. Kaunitz JD. Introduction to "DDS Citation Classics": Reaping Dividends from Rising Interest. Dig Dis Sci. 2019 09; 64(9):2384. PMID: 31346951.
      View in: PubMed
    9. Hollander D, Kaunitz JD. The "Leaky Gut": Tight Junctions but Loose Associations? Dig Dis Sci. 2019 Aug 30. PMID: 31471860.
      View in: PubMed
    10. D'Andrea V, Marino I, Kaunitz JD. DDS-SIRC Collaboration: L'Inizio di una Bella Amicizia. Dig Dis Sci. 2019 08; 64(8):2113. PMID: 31190202.
      View in: PubMed
    11. Iwasaki M, Akiba Y, Kaunitz JD. Duodenal Chemosensing of Short-Chain Fatty Acids: Implications for GI Diseases. Curr Gastroenterol Rep. 2019 Jul 10; 21(8):35. PMID: 31289927.
      View in: PubMed
    12. Iwasaki M, Akiba Y, Kaunitz JD. Duodenal chemosensing. Curr Opin Gastroenterol. 2018 11; 34(6):422-427. PMID: 30124472.
      View in: PubMed
    13. Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018 06 13; 23(6):775-785.e5. PMID: 29902441.
      View in: PubMed
    14. Kaunitz JD. Magnetic Resonance Imaging: The Nuclear Option. Dig Dis Sci. 2018 May; 63(5):1100-1101. PMID: 29497905.
      View in: PubMed
    15. Kaunitz JD, Akiba Y. A Tribute to Paul H. Guth, MD (1927-2017). Dig Dis Sci. 2018 Apr; 63(4):807-810. PMID: 29464586.
      View in: PubMed
    16. May FP, Yu C, Kaunitz J. High quality of cancer care in the Department of Veterans Affairs (VA). Am J Cancer Res. 2018; 8(4):761-762. PMID: 29736320.
      View in: PubMed
    17. Akiba Y, Kaunitz JD. [Duodenal mucosal defense mechanisms;Current update on 'Duodenology']. Nihon Shokakibyo Gakkai Zasshi. 2018; 115(2):137-159. PMID: 29459558.
      View in: PubMed
    18. Kaji I, Kaunitz JD. Luminal chemosensing in the gastroduodenal mucosa. Curr Opin Gastroenterol. 2017 Nov; 33(6):439-445. PMID: 28806271.
      View in: PubMed
    19. Akiba Y, Maruta K, Narimatsu K, Said H, Kaji I, Kuri A, Iwamoto KI, Kuwahara A, Kaunitz JD. FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 01; 313(2):G117-G128. PMID: 28526687.
      View in: PubMed
    20. Said H, Akiba Y, Narimatsu K, Maruta K, Kuri A, Iwamoto KI, Kuwahara A, Kaunitz JD. FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats. Dig Dis Sci. 2017 08; 62(8):1944-1952. PMID: 28523577.
      View in: PubMed
    21. Kaunitz JD. Development of Monoclonal Antibodies: The Dawn of mAb Rule. Dig Dis Sci. 2017 04; 62(4):831-832. PMID: 28181099.
      View in: PubMed
    22. Kaji I, Akiba Y, Kato I, Maruta K, Kuwahara A, Kaunitz JD. Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways. J Pharmacol Exp Ther. 2017 04; 361(1):151-161. PMID: 28115552.
      View in: PubMed
    23. Said H, Kaunitz JD. Gastrointestinal defense mechanisms. Curr Opin Gastroenterol. 2016 11; 32(6):461-466. PMID: 27653163.
      View in: PubMed
    24. Kaunitz JD. Welcome Associate Editors Ajay Goel, Aida Habtezion, and Walter Park. Dig Dis Sci. 2016 11; 61(11):3093-3094. PMID: 27696096.
      View in: PubMed
    25. Berg CJ, Kaunitz JD. Gut chemosensing: implications for disease pathogenesis. F1000Res. 2016; 5:2424. PMID: 27781093.
      View in: PubMed
    26. Kaunitz JD. DDS Elementary Style: A Brief Guide for Authors. Dig Dis Sci. 2016 08; 61(8):2147-2150. PMID: 27312030.
      View in: PubMed
    27. Duboc H, Tolstanova G, Yuan PQ, Wu V, Kaji I, Biraud M, Akiba Y, Kaunitz J, Million M, Tache Y, Larauche M. Reduction of epithelial secretion in male rat distal colonic mucosa by bile acid receptor TGR5 agonist, INT-777: role of submucosal neurons. Neurogastroenterol Motil. 2016 Nov; 28(11):1663-1676. PMID: 27259385.
      View in: PubMed
    28. Akiba Y, Kaunitz JD, Montrose MH. CFTR and pHi regulation. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G1183. PMID: 27281734.
      View in: PubMed
    29. Kaji I, Akiba Y, Konno K, Watanabe M, Kimura S, Iwanaga T, Kuri A, Iwamoto K, Kuwahara A, Kaunitz JD. Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon. J Physiol. 2016 06 15; 594(12):3339-52. PMID: 26854275.
      View in: PubMed
    30. Kaunitz JD. The Doppler Effect: A Century from Red Shift to Red Spot. Dig Dis Sci. 2016 Feb; 61(2):340-1. PMID: 26745970.
      View in: PubMed
    31. Said H, Kaji I, Kaunitz JD. Gastroduodenal mucosal defense mechanisms. Curr Opin Gastroenterol. 2015 Nov; 31(6):486-91. PMID: 26376476.
      View in: PubMed
    32. Kaunitz J, Nayyar P. Bugs, genes, fatty acids, and serotonin: Unraveling inflammatory bowel disease? F1000Res. 2015; 4. PMID: 27508055.
      View in: PubMed
    33. Kaunitz AM, Kaunitz JD. Compounded bioidentical hormone therapy: time for a reality check? Menopause. 2015 Sep; 22(9):919-20. PMID: 26035149.
      View in: PubMed
    34. Kaunitz JD. The Discovery of PCR: ProCuRement of Divine Power. Dig Dis Sci. 2015 Aug; 60(8):2230-1. PMID: 26077976.
      View in: PubMed
    35. Sakanaka T, Inoue T, Yorifuji N, Iguchi M, Fujiwara K, Narabayashi K, Kakimoto K, Nouda S, Okada T, Kuramoto T, Ishida K, Abe Y, Takeuchi T, Umegaki E, Akiba Y, Kaunitz JD, Higuchi K. The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice. J Gastroenterol Hepatol. 2015 Mar; 30 Suppl 1:60-5. PMID: 25827806.
      View in: PubMed
    36. Ahnen DJ, Bresalier RS, Levin B, Kaunitz JD. CRC screening, past, present, and future: a tribute to Emmet Keeffe. Dig Dis Sci. 2015 Mar; 60(3):589-91. PMID: 25724168.
      View in: PubMed
    37. Akiba Y, Kaunitz JD, Million M. Peripheral corticotropin-releasing factor receptor type 2 activation increases colonic blood flow through nitric oxide pathway in rats. Dig Dis Sci. 2015 Apr; 60(4):858-67. PMID: 25701320.
      View in: PubMed
    38. Akiba Y, Inoue T, Kaji I, Higashiyama M, Narimatsu K, Iwamoto K, Watanabe M, Guth PH, Engel E, Kuwahara A, Kaunitz JD. Short-chain fatty acid sensing in rat duodenum. J Physiol. 2015 Feb 01; 593(3):585-99. PMID: 25433076.
      View in: PubMed
    39. Fujiwara K, Inoue T, Yorifuji N, Iguchi M, Sakanaka T, Narabayashi K, Kakimoto K, Nouda S, Okada T, Ishida K, Abe Y, Masuda D, Takeuchi T, Fukunishi S, Umegaki E, Akiba Y, Kaunitz JD, Higuchi K. Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. J Clin Biochem Nutr. 2015 Mar; 56(2):155-62. PMID: 25759522.
      View in: PubMed
    40. Akiba Y, Kaunitz JD. Prostaglandin pathways in duodenal chemosensing. J Gastroenterol Hepatol. 2014 Dec; 29 Suppl 4:93-8. PMID: 25521740.
      View in: PubMed
    41. Kaji I, Iwanaga T, Watanabe M, Guth PH, Engel E, Kaunitz JD, Akiba Y. SCFA transport in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 01; 308(3):G188-97. PMID: 25394661.
      View in: PubMed
    42. Kaunitz JD. The fruits of fiber: the invention of the flexible fiberoptic gastroscope. Dig Dis Sci. 2014 Nov; 59(11):2616-8. PMID: 25193388.
      View in: PubMed
    43. Kemmerly T, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2014 Nov; 30(6):583-8. PMID: 25229259.
      View in: PubMed
    44. Kaunitz JD, Souza RF. Introduction to the "GRG profiles and perspectives" series. Dig Dis Sci. 2014 Sep; 59(9):2032. PMID: 25073957.
      View in: PubMed
    45. Rønnestad I, Akiba Y, Kaji I, Kaunitz JD. Duodenal luminal nutrient sensing. Curr Opin Pharmacol. 2014 Dec; 19:67-75. PMID: 25113991.
      View in: PubMed
    46. Kaunitz JD. Priming the (proton) pump. Dig Dis Sci. 2014 Jul; 59(7):1356-7. PMID: 24627261.
      View in: PubMed
    47. Kaunitz JD. Paradigm shifts in perspective III: the discovery of tumor necrosis factor. Dig Dis Sci. 2014 Apr; 59(4):710-1. PMID: 24557574.
      View in: PubMed
    48. Akiba Y, Kaunitz JD. Duodenal luminal chemosensing; acid, ATP, and nutrients. Curr Pharm Des. 2014; 20(16):2760-5. PMID: 23886391.
      View in: PubMed
    49. Inoue T, Higashiyama M, Kaji I, Rudenkyy S, Higuchi K, Guth PH, Engel E, Kaunitz JD, Akiba Y. Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig Dis Sci. 2014 Jun; 59(6):1286-95. PMID: 24379150.
      View in: PubMed
    50. Kemmerly T, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2013 Nov; 29(6):642-9. PMID: 24100725.
      View in: PubMed
    51. Kaunitz JD. Bringing the Bacon home. Dig Dis Sci. 2013 Nov; 58(11):3070-1. PMID: 24122621.
      View in: PubMed
    52. Soldavini J, Kaunitz JD. Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity. Dig Dis Sci. 2013 Oct; 58(10):2756-66. PMID: 23839339.
      View in: PubMed
    53. Kaunitz JD. Introduction to the "paradigm shifts in perspective" series. Dig Dis Sci. 2013 Jul; 58(7):1825-6. PMID: 23756736.
      View in: PubMed
    54. Kaunitz JD, Akiba Y. Wireless telemetry and cystic fibrosis: just the pHacts. Dig Dis Sci. 2013 Aug; 58(8):2129-30. PMID: 23748712.
      View in: PubMed
    55. Souza RF, Kaunitz JD. Introduction to the "GRG Scholars Invited Reviews". Dig Dis Sci. 2013 May; 58(5):1175. PMID: 23579293.
      View in: PubMed
    56. Palileo BM, Kaunitz JD. Covering digestive diseases and sciences: how to judge a journal by its cover. Dig Dis Sci. 2013 Mar; 58(3):592-5. PMID: 23504332.
      View in: PubMed
    57. Akiba Y, Kaunitz JD. May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Dig Dis Sci. 2012 Nov; 57(11):2740-2. PMID: 23001408.
      View in: PubMed
    58. Al-Jiboury H, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2012 Nov; 28(6):594-601. PMID: 22954689.
      View in: PubMed
    59. Kaunitz JD. From bedside to bench: reverse engineering medical progress. Dig Dis Sci. 2012 Oct; 57(10):2481-3. PMID: 22983560.
      View in: PubMed
    60. Inoue T, Wang JH, Higashiyama M, Rudenkyy S, Higuchi K, Guth PH, Engel E, Kaunitz JD, Akiba Y. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2012 Oct; 303(7):G810-6. PMID: 22821947.
      View in: PubMed
    61. Palileo C, Kaunitz JD. Gastrointestinal defense mechanisms. Curr Opin Gastroenterol. 2011 Oct; 27(6):543-8. PMID: 21897225.
      View in: PubMed
    62. Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD, Akiba Y. Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther. 2011 Nov; 339(2):464-73. PMID: 21846840.
      View in: PubMed
    63. Hershcovici T, Poh CH, Fass OZ, Ashpole N, Akiba Y, Guillén-Rodríguez JM, Kaunitz JD, Fass R. Oesophageal sensation in response to high PCO(2) and acidic solutions in nonerosive reflux disease. Eur J Clin Invest. 2012 Feb; 42(2):195-202. PMID: 21679182.
      View in: PubMed
    64. Akiba Y, Kaunitz JD. Duodenal chemosensing and mucosal defenses. Digestion. 2011; 83 Suppl 1:25-31. PMID: 21389725.
      View in: PubMed
    65. Kaunitz JD, Akiba Y. Purinergic regulation of duodenal surface pH and ATP concentration: implications for mucosal defence, lipid uptake and cystic fibrosis. Acta Physiol (Oxf). 2011 Jan; 201(1):109-16. PMID: 20560899.
      View in: PubMed
    66. Akiba Y, Kaunitz JD. Duodenal chemosensing: master control for epigastric sensation? J Gastroenterol Hepatol. 2011 Jan; 26(1):6-7. PMID: 21073675.
      View in: PubMed
    67. Goo T, Akiba Y, Kaunitz JD. Mechanisms of intragastric pH sensing. Curr Gastroenterol Rep. 2010 Dec; 12(6):465-70. PMID: 20938760.
      View in: PubMed
    68. deFoneska A, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2010 Nov; 26(6):604-10. PMID: 20948371.
      View in: PubMed
    69. Akiba Y, Kaunitz JD. Lafutidine, a protective H2 receptor antagonist, enhances mucosal defense in rat esophagus. Dig Dis Sci. 2010 Nov; 55(11):3063-9. PMID: 20824506.
      View in: PubMed
    70. Ham M, Mizumori M, Watanabe C, Wang JH, Inoue T, Nakano T, Guth PH, Engel E, Kaunitz JD, Akiba Y. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther. 2010 Dec; 335(3):607-13. PMID: 20805305.
      View in: PubMed
    71. Bergmann LL, Zimmerman P, Kaunitz JD. Unusual complication: superior mesenteric artery syndrome and closed loop gastroduodenal obstruction after adjustable gastric banding. Surg Obes Relat Dis. 2011 Mar-Apr; 7(2):237-9. PMID: 21130049.
      View in: PubMed
    72. Zhu A, Kaneshiro M, Kaunitz JD. Evaluation and treatment of iron deficiency anemia: a gastroenterological perspective. Dig Dis Sci. 2010 Mar; 55(3):548-59. PMID: 20108038.
      View in: PubMed
    73. deFonseka A, Kaunitz J. Gut sensing mechanisms. Curr Gastroenterol Rep. 2009 Dec; 11(6):442-7. PMID: 19903419.
      View in: PubMed
    74. Nayeb-Hashemi H, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2009 Nov; 25(6):537-43. PMID: 19654540.
      View in: PubMed
    75. Mizumori M, Akiba Y, Kaunitz JD. Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig Dis Sci. 2009 Oct; 54(10):2063-9. PMID: 19657734.
      View in: PubMed
    76. Akiba Y, Watanabe C, Mizumori M, Kaunitz JD. Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G781-91. PMID: 19643955.
      View in: PubMed
    77. Akiba Y, Kaunitz JD. Luminal chemosensing and upper gastrointestinal mucosal defenses. Am J Clin Nutr. 2009 Sep; 90(3):826S-831S. PMID: 19571224.
      View in: PubMed
    78. Mizumori M, Ham M, Guth PH, Engel E, Kaunitz JD, Akiba Y. Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol. 2009 Jul 15; 587(Pt 14):3651-63. PMID: 19451200.
      View in: PubMed
    79. Nakano T, Inoue I, Alpers DH, Akiba Y, Katayama S, Shinozaki R, Kaunitz JD, Ohshima S, Akita M, Takahashi S, Koyama I, Matsushita M, Komoda T. Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration. Am J Physiol Gastrointest Liver Physiol. 2009 Jul; 297(1):G207-14. PMID: 19407215.
      View in: PubMed
    80. Zhu A, Kaunitz J. Gastroduodenal mucosal defense. Curr Gastroenterol Rep. 2008 Dec; 10(6):548-54. PMID: 19006609.
      View in: PubMed
    81. Ham M, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2008 Nov; 24(6):665-73. PMID: 19122513.
      View in: PubMed
    82. Kaunitz JD, Yamaguchi DT. TNAP, TrAP, ecto-purinergic signaling, and bone remodeling. J Cell Biochem. 2008 Oct 15; 105(3):655-62. PMID: 18773425.
      View in: PubMed
    83. Mizumori M, Choi Y, Guth PH, Engel E, Kaunitz JD, Akiba Y. CFTR inhibition augments NHE3 activity during luminal high CO2 exposure in rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 294(6):G1318-27. PMID: 18420826.
      View in: PubMed
    84. Guth PH, Kaunitz JD. Personal reminiscences about Morton Grossman and the founding of the Center for Ulcer Research and Education (CURE). Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1109-13. PMID: 18356532.
      View in: PubMed
    85. Ham M, Kaunitz JD. Gastroduodenal defense. Curr Opin Gastroenterol. 2007 Nov; 23(6):607-16. PMID: 17906436.
      View in: PubMed
    86. Akiba Y, Mizumori M, Guth PH, Engel E, Kaunitz JD. Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1223-33. PMID: 17916646.
      View in: PubMed
    87. Ham M, Horton K, Kaunitz J. Fistuloclysis: case report and literature review. Nutr Clin Pract. 2007 Oct; 22(5):553-7. PMID: 17906279.
      View in: PubMed
    88. Minagawa N, Nagata J, Shibao K, Masyuk AI, Gomes DA, Rodrigues MA, Lesage G, Akiba Y, Kaunitz JD, Ehrlich BE, Larusso NF, Nathanson MH. Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology. 2007 Nov; 133(5):1592-602. PMID: 17916355.
      View in: PubMed
    89. Kaunitz JD. NKCC1: tales from the dark side of the crypt. J Physiol. 2007 Jul 15; 582(Pt 2):477. PMID: 17525110.
      View in: PubMed
    90. Smith JP, Dong MH, Kaunitz JD. Evaluation of a pharmacist-managed hepatitis C care clinic. Am J Health Syst Pharm. 2007 Mar 15; 64(6):632-6. PMID: 17353572.
      View in: PubMed
    91. Kaunitz JD, Akiba Y. Review article: duodenal bicarbonate - mucosal protection, luminal chemosensing and acid-base balance. Aliment Pharmacol Ther. 2006 Dec; 24 Suppl 4:169-76. PMID: 17209861.
      View in: PubMed
    92. Dong MH, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2006 Nov; 22(6):599-606. PMID: 17053436.
      View in: PubMed
    93. Kaunitz JD, Akiba Y. Duodenal carbonic anhydrase: mucosal protection, luminal chemosensing, and gastric acid disposal. Keio J Med. 2006 Sep; 55(3):96-106. PMID: 17008801.
      View in: PubMed
    94. Akiba Y, Ghayouri S, Takeuchi T, Mizumori M, Guth PH, Engel E, Swenson ER, Kaunitz JD. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Gastroenterology. 2006 Jul; 131(1):142-52. PMID: 16831598.
      View in: PubMed
    95. Mizumori M, Meyerowitz J, Takeuchi T, Lim S, Lee P, Supuran CT, Guth PH, Engel E, Kaunitz JD, Akiba Y. Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol. 2006 Jun 15; 573(Pt 3):827-42. PMID: 16556652.
      View in: PubMed
    96. Akiba Y, Jung M, Ouk S, Kaunitz JD. A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G753-9. PMID: 15905414.
      View in: PubMed
    97. Kawakubo K, Akiba Y, Adelson D, Guth PH, Engel E, Taché Y, Kaunitz JD. Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats. Peptides. 2005 Sep; 26(9):1580-9. PMID: 16112396.
      View in: PubMed
    98. Kaunitz JD, Akiba Y. Gastroduodenal mucosal defense: role of endogenous mediators. Curr Opin Gastroenterol. 2004 Nov; 20(6):526-32. PMID: 15703677.
      View in: PubMed
    99. Furukawa O, Hirokawa M, Zhang L, Takeuchi T, Bi LC, Guth PH, Engel E, Akiba Y, Kaunitz JD. Mechanism of augmented duodenal HCO(3)(-) secretion after elevation of luminal CO(2). Am J Physiol Gastrointest Liver Physiol. 2005 Mar; 288(3):G557-63. PMID: 15499081.
      View in: PubMed
    100. Hirokawa M, Takeuchi T, Chu S, Akiba Y, Wu V, Guth PH, Engel E, Montrose MH, Kaunitz JD. Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum. Gastroenterology. 2004 Oct; 127(4):1162-73. PMID: 15480994.
      View in: PubMed
    101. Hirokawa M, Furukawa O, Guth PH, Engel E, Kaunitz JD. Low-dose PGE2 mimics the duodenal secretory response to luminal acid in mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G891-8. PMID: 14764447.
      View in: PubMed
    102. Kaunitz JD, Akiba Y. Acid-sensing protective mechanisms of duodenum. J Physiol Pharmacol. 2003 Dec; 54 Suppl 4:19-26. PMID: 15075446.
      View in: PubMed
    103. Bi LC, Kaunitz JD. Gastroduodenal mucosal defense: an integrated protective response. Curr Opin Gastroenterol. 2003 Nov; 19(6):526-32. PMID: 15703600.
      View in: PubMed
    104. Furukawa O, Bi LC, Guth PH, Engel E, Hirokawa M, Kaunitz JD. NHE3 inhibition activates duodenal bicarbonate secretion in the rat. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G102-9. PMID: 12881227.
      View in: PubMed
    105. Furukawa O, Hirokawa M, Guth PH, Engel E, Kaunitz JD. Role of protein kinases on acid-induced duodenal bicarbonate secretion in rats. Pharmacology. 2003 Feb; 67(2):99-105. PMID: 12566854.
      View in: PubMed
    106. Akiba Y, Nakamura M, Nagata H, Kaunitz JD, Ishii H. Acid-sensing pathways in rat gastrointestinal mucosa. J Gastroenterol. 2002 Nov; 37 Suppl 14:133-8. PMID: 12572881.
      View in: PubMed
    107. Guha S, Kaunitz JD. Gastroduodenal mucosal defense: an integrated protective response. Curr Opin Gastroenterol. 2002 Nov; 18(6):650-7. PMID: 17033343.
      View in: PubMed
    108. Kaunitz JD, Akiba Y. Luminal acid elicits a protective duodenal mucosal response. Keio J Med. 2002 Mar; 51(1):29-35. PMID: 11951376.
      View in: PubMed
    109. Kaunitz JD, Akiba Y. Integrated duodenal protective response to acid. Life Sci. 2001 Nov 09; 69(25-26):3073-81. PMID: 11758832.
      View in: PubMed
    110. Kaunitz JD, Akiba Y. Duodenal intracellular bicarbonate and the 'CF paradox'. JOP. 2001 Jul; 2(4 Suppl):268-73. PMID: 11875270.
      View in: PubMed
    111. Kaunitz JD. Barrier function of gastric mucus. Keio J Med. 1999 Jun; 48(2):63-8. PMID: 10405521.
      View in: PubMed