Jonathan Frederic Rest Flint

Title(s)Professor-in-Residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
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    Title(s)Professor-in-Residence, Human Genetics


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    Dr. Jonathan Flint holds the Billy and Audrey Wilder Endowed Chair in Psychiatry and Neuroscience.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study. Mol Psychiatry. 2024 Dec 31. Di Y, Rahmani E, Mefford J, Wang J, Ravi V, Gorla A, Alwan A, Kendler KS, Zhu T, Flint J. PMID: 39741179.
      View in: PubMed   Mentions:    Fields:    
    2. Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression. Am J Hum Genet. 2024 Nov 07; 111(11):2494-2509. Dybdahl Krebs M, Georgii Hellberg KL, Lundberg M, Appadurai V, Ohlsson H, Pedersen E, Steinbach J, Matthews J, Border R, LaBianca S, Calle X, Meijsen JJ, iPSYCH Study Consortium, , Ingason A, Buil A, Vilhjálmsson BJ, Flint J, Bacanu SA, Cai N, Dahl A, Zaitlen N, Werge T, Kendler KS, Schork AJ. PMID: 39471805; PMCID: PMC11568754.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Unraveling the Associations Between Voice Pitch and Major Depressive Disorder: A Multisite Genetic Study. medRxiv. 2024 Oct 13. Di Y, Rahmani E, Mefford J, Wang J, Ravi V, Gorla A, Alwan A, Kendler KS, Zhu T, Flint J. PMID: 39417141; PMCID: PMC11482971.
      View in: PubMed   Mentions:
    4. Epigenetic patient stratification via contrastive machine learning refines hallmark biomarkers in minoritized children with asthma. Res Sq. 2024 Sep 13. Gorla A, Witonsky J, Elhawary JR, Chen ZJ, Mefford J, Perez-Garcia J, Huntsman S, Hu D, Eng C, Woodruff PG, Sankararaman S, Ziv E, Flint J, Zaitlen N, Burchard E, Rahmani E. PMID: 39315258; PMCID: PMC11419268.
      View in: PubMed   Mentions:
    5. Speechformer-CTC: Sequential Modeling of Depression Detection with Speech Temporal Classification. Speech Commun. 2024 Sep; 163. Wang J, Ravi V, Flint J, Alwan A. PMID: 39364289; PMCID: PMC11449263.
      View in: PubMed   Mentions: 2  
    6. Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. Commun Biol. 2024 05 07; 7(1):540. Di Y, Mefford J, Rahmani E, Wang J, Ravi V, Gorla A, Alwan A, Zhu T, Flint J. PMID: 38714798; PMCID: PMC11076565.
      View in: PubMed   Mentions: Translation:Humans
    7. Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior. Cell Genom. 2024 May 08; 4(5):100545. Chen PB, Chen R, LaPierre N, Chen Z, Mefford J, Marcus E, Heffel MG, Soto DC, Ernst J, Luo C, Flint J. PMID: 38697120; PMCID: PMC11099346.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Personalized mood prediction from patterns of behavior collected with smartphones. NPJ Digit Med. 2024 Feb 28; 7(1):49. Balliu B, Douglas C, Seok D, Shenhav L, Wu Y, Chatzopoulou D, Kaiser W, Chen V, Kim J, Deverasetty S, Arnaudova I, Gibbons R, Congdon E, Craske MG, Freimer N, Halperin E, Sankararaman S, Flint J. PMID: 38418551; PMCID: PMC10902386.
      View in: PubMed   Mentions: 2  
    9. A Privacy-Preserving Unsupervised Speaker Disentanglement Method for Depression Detection from Speech. CEUR Workshop Proc. 2024 Feb; 3649:57-63. Ravi V, Wang J, Flint J, Alwan A. PMID: 38650610; PMCID: PMC11034881.
      View in: PubMed   Mentions: 1  
    10. Enhancing accuracy and privacy in speech-based depression detection through speaker disentanglement. Comput Speech Lang. 2024 Jun; 86. Ravi V, Wang J, Flint J, Alwan A. PMID: 38313320; PMCID: PMC10836190.
      View in: PubMed   Mentions: 2  
    11. Single-cell methylation analysis of brain tissue prioritizes mutations that alter transcription. Cell Genom. 2023 12 13; 3(12):100454. Flint J, Heffel MG, Chen Z, Mefford J, Marcus E, Chen PB, Ernst J, Luo C. PMID: 38116123; PMCID: PMC10726494.
      View in: PubMed   Mentions: 2     Fields:    
    12. Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. Nat Genet. 2023 Dec; 55(12):2082-2093. Dahl A, Thompson M, An U, Krebs M, Appadurai V, Border R, Bacanu SA, Werge T, Flint J, Schork AJ, Sankararaman S, Kendler KS, Cai N. PMID: 37985818; PMCID: PMC10703686.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    13. Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries. Nat Genet. 2023 Dec; 55(12):2269-2276. An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S. PMID: 37985819; PMCID: PMC10703681.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing. Genome Biol. 2023 09 29; 24(1):215. Cui L, Yang B, Xiao S, Gao J, Baud A, Graham D, McBride M, Dominiczak A, Schafer S, Aumatell RL, Mont C, Teruel AF, Hübner N, Flint J, Mott R, Huang L. PMID: 37773188; PMCID: PMC10540365.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. The genetic basis of major depressive disorder. Mol Psychiatry. 2023 06; 28(6):2254-2265. Flint J. PMID: 36702864; PMCID: PMC10611584.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    16. Phenotypic subtyping via contrastive learning. bioRxiv. 2023 Jan 06. Gorla A, Sankararaman S, Burchard E, Flint J, Zaitlen N, Rahmani E. PMID: 36711575; PMCID: PMC9881932.
      View in: PubMed   Mentions:
    17. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 2022 11 18; 378(6621):754-761. Border R, Athanasiadis G, Buil A, Schork AJ, Cai N, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA. PMID: 36395242; PMCID: PMC9901291.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    18. A Step Towards Preserving Speakers' Identity While Detecting Depression Via Speaker Disentanglement. Interspeech. 2022 Sep; 2022:3338-3342. Ravi V, Wang J, Flint J, Alwan A. PMID: 36341467; PMCID: PMC9635494.
      View in: PubMed   Mentions: 4  
    19. A comprehensive benchmarking of WGS-based deletion structural variant callers. Brief Bioinform. 2022 07 18; 23(4). Sarwal V, Niehus S, Ayyala R, Kim M, Sarkar A, Chang S, Lu A, Rajkumar N, Darfci-Maher N, Littman R, Chhugani K, Soylev A, Comarova Z, Wesel E, Castellanos J, Chikka R, Distler MG, Eskin E, Flint J, Mangul S. PMID: 35753701; PMCID: PMC9294411.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    20. FRAUG: A FRAME RATE BASED DATA AUGMENTATION METHOD FOR DEPRESSION DETECTION FROM SPEECH SIGNALS. Proc IEEE Int Conf Acoust Speech Signal Process. 2022 May; 2022:6267-6271. Ravi V, Wang J, Flint J, Alwan A. PMID: 35531125; PMCID: PMC9070766.
      View in: PubMed   Mentions: 8  
    21. Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA. BMC Genomics. 2022 Apr 04; 23(1):260. Guo L, Boocock J, Hilt EE, Chandrasekaran S, Zhang Y, Munugala C, Sathe L, Alexander N, Arboleda VA, Flint J, Eskin E, Luo C, Yang S, Garner OB, Yin Y, Bloom JS, Kruglyak L. PMID: 35379194; PMCID: PMC8978495.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    22. Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility. G3 (Bethesda). 2022 01 04; 12(1). Zou J, Gopalakrishnan S, Parker CC, Nicod J, Mott R, Cai N, Lionikas A, Davies RW, Palmer AA, Flint J. PMID: 34791208; PMCID: PMC8728023.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    23. Unsupervised Instance Discriminative Learning for Depression Detection from Speech Signals. Interspeech. 2022; 2022:2018-2022. Wang J, Ravi V, Flint J, Alwan A. PMID: 36341466; PMCID: PMC9634944.
      View in: PubMed   Mentions: 3  
    24. Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California. Open Forum Infect Dis. 2021 Nov; 8(11):ofab526. Adamson PC, Pfeffer MA, Arboleda VA, Garner OB, de St Maurice A, von Bredow B, Flint J, Kruglyak L, Currier JS. PMID: 35005055; PMCID: PMC8689969.
      View in: PubMed   Mentions: 2  
    25. What connectomics can learn from genomics. PLoS Genet. 2021 07; 17(7):e1009692. Chen PB, Flint J. PMID: 34270560; PMCID: PMC8318269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    26. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nat Biomed Eng. 2021 07; 5(7):657-665. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 34211145; PMCID: PMC10810734.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    27. Leveraging eQTLs to identify individual-level tissue of interest for a complex trait. PLoS Comput Biol. 2021 05; 17(5):e1008915. Majumdar A, Giambartolomei C, Cai N, Haldar T, Schwarz T, Gandal M, Flint J, Pasaniuc B. PMID: 34019542; PMCID: PMC8174686.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv. 2021 Mar 09. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 32909008; PMCID: PMC7480060.
      View in: PubMed   Mentions: 2  
    29. Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel. Am J Med Genet B Neuropsychiatr Genet. 2021 01; 186(1):16-27. Chatzinakos C, Lee D, Cai N, Vladimirov VI, Webb BT, Riley BP, Flint J, Kendler KS, Ressler KJ, Daskalakis NP, Bacanu SA. PMID: 33576176; PMCID: PMC8247874.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet. 2020 12; 183(8):454-463. Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. PMID: 32954640; PMCID: PMC7756231.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    31. Retraction Note: 11,670 whole-genome sequences representative of the Han Chinese population from the CONVERGE project. Sci Data. 2020 04 16; 7(1):123. Cai N, Bigdeli TB, Kretzschmar WW, Li Y, Liang J, Hu J, Peterson RE, Bacanu S, Webb BT, Riley B, Li Q, Marchini J, Mott R, Kendler KS, Flint J. PMID: 32300216; PMCID: PMC7162935.
      View in: PubMed   Mentions:    Fields:    
    32. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet. 2020 04; 52(4):437-447. Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Pistis G, Potash JB, Preisig M, Shi J, Smoller JW, Streit F, Tiemeier H, Uher R, Van der Auwera S, Viktorin A, Weissman MM, MDD Working Group of the Psychiatric Genomics Consortium, Kendler KS, Flint J. PMID: 32231276; PMCID: PMC7906795.
      View in: PubMed   Mentions: 131     Fields:    Translation:Humans
    33. A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. Am J Hum Genet. 2020 01 02; 106(1):71-91. Dahl A, Nguyen K, Cai N, Gandal MJ, Flint J, Zaitlen N. PMID: 31901249; PMCID: PMC7042488.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    34. The great hairball gambit. PLoS Genet. 2019 11; 15(11):e1008519. Flint J, Ideker T. PMID: 31770365; PMCID: PMC6910700.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Challenges and recommendations to improve the installability and archival stability of omics computational tools. PLoS Biol. 2019 06; 17(6):e3000333. Mangul S, Mosqueiro T, Abdill RJ, Duong D, Mitchell K, Sarwal V, Hill B, Brito J, Littman RJ, Statz B, Lam AK, Dayama G, Grieneisen L, Martin LS, Flint J, Eskin E, Blekhman R. PMID: 31220077; PMCID: PMC6605654.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    36. Re-examining the robustness of voice features in predicting depression: Compared with baseline of confounders. PLoS One. 2019; 14(6):e0218172. Pan W, Flint J, Shenhav L, Liu T, Liu M, Hu B, Zhu T. PMID: 31220113; PMCID: PMC6586278.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    37. Reverse GWAS: Using genetics to identify and model phenotypic subtypes. PLoS Genet. 2019 04; 15(4):e1008009. Dahl A, Cai N, Ko A, Laakso M, Pajukanta P, Flint J, Zaitlen N. PMID: 30951530; PMCID: PMC6469799.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    38. Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE. Psychol Med. 2020 04; 50(5):793-798. Docherty AR, Moscati A, Bigdeli TB, Edwards AC, Peterson RE, Adkins DE, Anderson JS, Flint J, Kendler KS, Bacanu SA. PMID: 30935430; PMCID: PMC6774907.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Systematic benchmarking of omics computational tools. Nat Commun. 2019 03 27; 10(1):1393. Mangul S, Martin LS, Hill BL, Lam AK, Distler MG, Zelikovsky A, Eskin E, Flint J. PMID: 30918265; PMCID: PMC6437167.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    40. Outside in. PLoS Genet. 2019 02; 15(2):e1008014. Flint J. PMID: 30817793; PMCID: PMC6394895.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    41. Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat. G3 (Bethesda). 2018 10 03; 8(10):3283-3291. Mont C, Hernandez-Pliego P, Cañete T, Oliveras I, Río-Álamos C, Blázquez G, López-Aumatell R, Martínez-Membrives E, Tobeña A, Flint J, Fernández-Teruel A, Mott R. PMID: 30135107; PMCID: PMC6169385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    42. Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci. Nat Genet. 2018 11; 50(11):1574-1583. Lilue J, Doran AG, Fiddes IT, Abrudan M, Armstrong J, Bennett R, Chow W, Collins J, Collins S, Czechanski A, Danecek P, Diekhans M, Dolle DD, Dunn M, Durbin R, Earl D, Ferguson-Smith A, Flicek P, Flint J, Frankish A, Fu B, Gerstein M, Gilbert J, Goodstadt L, Harrow J, Howe K, Ibarra-Soria X, Kolmogorov M, Lelliott CJ, Logan DW, Loveland J, Mathews CE, Mott R, Muir P, Nachtweide S, Navarro FCP, Odom DT, Park N, Pelan S, Pham SK, Quail M, Reinholdt L, Romoth L, Shirley L, Sisu C, Sjoberg-Herrera M, Stanke M, Steward C, Thomas M, Threadgold G, Thybert D, Torrance J, Wong K, Wood J, Yalcin B, Yang F, Adams DJ, Paten B, Keane TM. PMID: 30275530; PMCID: PMC6205630.
      View in: PubMed   Mentions: 119     Fields:    Translation:Animals
    43. Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018 Aug; 21(8):1139. Gstrein T, Edwards A, Pristoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA. PMID: 29875394.
      View in: PubMed   Mentions: 1     Fields:    
    44. Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics. Am J Hum Genet. 2018 07 05; 103(1):89-99. Weissbrod O, Flint J, Rosset S. PMID: 29979983; PMCID: PMC6035374.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    45. Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression. Am J Psychiatry. 2018 06 01; 175(6):545-554. Peterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS. PMID: 29495898; PMCID: PMC5988935.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    46. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018 02; 21(2):207-217. Gstrein T, Edwards A, Pristoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA. PMID: 29311744; PMCID: PMC5897053.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    47. Deep Reads: How I learnt to love population genetics. PLoS Genet. 2017 12; 13(12):e1007140. Flint J. PMID: 29267281; PMCID: PMC5739349.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    48. The centrality of DSM and non-DSM depressive symptoms in Han Chinese women with major depression. J Affect Disord. 2018 02; 227:739-744. Kendler KS, Aggen SH, Flint J, Borsboom D, Fried EI. PMID: 29179144; PMCID: PMC5815309.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    49. A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability. Hum Mol Genet. 2017 10 15; 26(20):3869-3882. Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A, WGS500 Consortium, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC. PMID: 29016847; PMCID: PMC5639461.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    50. Identifying genes for neurobehavioural traits in rodents: progress and pitfalls. Dis Model Mech. 2017 04 01; 10(4):373-383. Baud A, Flint J. PMID: 28381599; PMCID: PMC5399566.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    51. 11,670 whole-genome sequences representative of the Han Chinese population from the CONVERGE project. Sci Data. 2017 02 14; 4:170011. Cai N, Bigdeli TB, Kretzschmar WW, Li Y, Liang J, Hu J, Peterson RE, Bacanu S, Webb BT, Riley B, Li Q, Marchini J, Mott R, Kendler KS, Flint J. PMID: 28195579; PMCID: PMC5308202.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    52. Age of onset and family history as indicators of polygenic risk for major depression. Depress Anxiety. 2017 05; 34(5):446-452. Docherty AR, Edwards AC, Yang F, Peterson RE, Sawyers C, Adkins DE, Moore AA, Webb BT, Bacanu SA, Flint J, Kendler KS. PMID: 28152564; PMCID: PMC5501985.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    53. The Genetic Architecture of Major Depressive Disorder in Han Chinese Women. JAMA Psychiatry. 2017 02 01; 74(2):162-168. Peterson RE, Cai N, Bigdeli TB, Li Y, Reimers M, Nikulova A, Webb BT, Bacanu SA, Riley BP, Flint J, Kendler KS. PMID: 28002544; PMCID: PMC5319866.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    54. A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda). 2016 08 09; 6(8):2343-54. McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ. PMID: 27233670; PMCID: PMC4978889.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    55. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. Genome Biol. 2016 08 01; 17(1):167. Doran AG, Wong K, Flint J, Adams DJ, Hunter KW, Keane TM. PMID: 27480531; PMCID: PMC4968449.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    56. Rapid genotype imputation from sequence without reference panels. Nat Genet. 2016 08; 48(8):965-969. Davies RW, Flint J, Myers S, Mott R. PMID: 27376236; PMCID: PMC4966640.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimals
    57. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nat Genet. 2016 08; 48(8):912-8. Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L, Cosgrove C, Yee BK, Lionikaite V, McIntyre RE, Remme CA, Lodder EM, Gregory JS, Hough T, Joynson R, Phelps H, Nell B, Rowe C, Wood J, Walling A, Bopp N, Bhomra A, Hernandez-Pliego P, Callebert J, Aspden RM, Talbot NP, Robbins PA, Harrison M, Fray M, Launay JM, Pinto YM, Blizard DA, Bezzina CR, Adams DJ, Franken P, Weaver T, Wells S, Brown SD, Potter PK, Klenerman P, Lionikas A, Mott R, Flint J. PMID: 27376238; PMCID: PMC4966644.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    58. CHRONICITY OF DEPRESSION AND MOLECULAR MARKERS IN A LARGE SAMPLE OF HAN CHINESE WOMEN. Depress Anxiety. 2016 Nov; 33(11):1048-1054. Edwards AC, Aggen SH, Cai N, Bigdeli TB, Peterson RE, Docherty AR, Webb BT, Bacanu SA, Flint J, Kendler KS. PMID: 27110890; PMCID: PMC5079854.
      View in: PubMed   Mentions: 12     Fields:    
    59. Rare genetic variants and schizophrenia. Nat Neurosci. 2016 Apr; 19(4):525-7. Flint J. PMID: 27021940.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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    109. The impact of educational status on the clinical features of major depressive disorder among Chinese women. J Affect Disord. 2012 Feb; 136(3):988-92. Gan Z, Li Y, Xie D, Shao C, Yang F, Shen Y, Zhang N, Zhang G, Tian T, Yin A, Chen C, Liu J, Tang C, Zhang Z, Liu J, Sang W, Wang X, Liu T, Wei Q, Xu Y, Sun L, Wang S, Li C, Hu C, Cui Y, Liu Y, Li Y, Zhao X, Zhang L, Sun L, Chen Y, Zhang Y, Ning Y, Shi S, Chen Y, Kendler KS, Flint J, Zhang J. PMID: 21824664; PMCID: PMC3314924.
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    110. A comparison of the clinical characteristics of Chinese patients with recurrent major depressive disorder with and without dysthymia. J Affect Disord. 2011 Dec; 135(1-3):106-10. Sang W, Li Y, Su L, Yang F, Wu W, Shang X, Zhang G, Shen J, Sun M, Guo L, Li Z, Yan L, Zhang B, Wang G, Liu G, Liu T, Zhang J, Wang Y, Yu B, Pan J, Li Y, Hu C, Yang L, Huang Y, Xie S, Wang X, Liu J, Lv L, Chen Y, Zhang L, Dang Y, Shi S, Chen Y, Kendler KS, Flint J, Li K. PMID: 21824660; PMCID: PMC3221043.
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    111. The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women. J Affect Disord. 2011 Dec; 135(1-3):100-5. Xia J, He Q, Li Y, Xie D, Zhu S, Chen J, Shen Y, Zhang N, Wei Y, Chen C, Shen J, Zhang Y, Gao C, Li Y, Ding J, Shen W, Wang Q, Cao M, Liu T, Zhang J, Duan H, Bao C, Ma P, Zhou C, Luo Y, Zhang F, Liu Y, Li Y, Jin G, Zhang Y, Liang W, Chen Y, Zhao C, Li H, Chen Y, Shi S, Kendler KS, Flint J, Wang X. PMID: 21824661; PMCID: PMC3220767.
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    112. Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women. J Affect Disord. 2011 Dec; 135(1-3):95-9. Tao M, Li Y, Xie D, Wang Z, Qiu J, Wu W, Sun J, Wang Z, Tao D, Zhao H, Tian T, Zhang J, Gao C, Niu Q, Li Q, Liu S, Liu J, Zhang Y, He Q, Rong H, Gan Z, Li J, Chen X, Pan J, Li Y, Cui Y, Han W, Ma H, Xie S, Jin G, Li L, Zhang R, Tan Q, Zhang J, Guan J, Shi S, Chen Y, Kendler KS, Flint J, Gao J. PMID: 21821294; PMCID: PMC3210899.
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    113. Age at onset of major depressive disorder in Han Chinese women: relationship with clinical features and family history. J Affect Disord. 2011 Dec; 135(1-3):89-94. Yang F, Li Y, Xie D, Shao C, Ren J, Wu W, Zhang N, Zhang Z, Zou Y, Zhang J, Qiao D, Gao C, Li Y, Hu J, Deng H, Wang G, Du B, Wang X, Liu T, Gan Z, Peng J, Wei B, Pan J, Chen H, Sun S, Jia H, Liu Y, Chen Q, Wang X, Cao J, Lv L, Chen Y, Ha B, Ning Y, Chen Y, Kendler KS, Flint J, Shi S. PMID: 21782247; PMCID: PMC3210897.
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    114. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol. 2010 Dec 14; 8(12):e1000561. Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Sim S, Parent JM, Johnsen A, Mott R, Mathis D, Klenerman P, Benoist C, Flint J. PMID: 21179499; PMCID: PMC3001898.
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    115. Elusive copy number variation in the mouse genome. PLoS One. 2010 Sep 21; 5(9):e12839. Agam A, Yalcin B, Bhomra A, Cubin M, Webber C, Holmes C, Flint J, Mott R. PMID: 20877625; PMCID: PMC2943477.
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    116. Commercially available outbred mice for genome-wide association studies. PLoS Genet. 2010 Sep 02; 6(9):e1001085. Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, Østerås M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, Adams DJ, Mott R, Flint J. PMID: 20838427; PMCID: PMC2932682.
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    117. Mapping quantitative traits and strategies to find quantitative trait genes. Methods. 2011 Feb; 53(2):163-74. Flint J. PMID: 20643209; PMCID: PMC3036800.
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    118. Mapping in structured populations by resample model averaging. Genetics. 2009 Aug; 182(4):1263-77. Valdar W, Holmes CC, Mott R, Flint J. PMID: 19474203; PMCID: PMC2728864.
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    119. Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res. 2009 May; 19(5):723-33. Flint J, Mackay TF. PMID: 19411597; PMCID: PMC3647534.
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    120. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Res. 2009 Jun; 19(6):1133-40. Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J. PMID: 19376938; PMCID: PMC2694476.
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    121. Is there an association between NPY and neuroticism? Nature. 2009 Apr 02; 458(7238):E6; discussion E7. Cotton CH, Flint J, Campbell TG. PMID: 19340021.
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    122. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 05; 150B(2):271-81. Munafò MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Järvelin MR, Taanila A, Flint J. PMID: 18546120; PMCID: PMC2819421.
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    123. Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. Alcohol Clin Exp Res. 2009 Mar; 33(3):531-7. Bice P, Valdar W, Zhang L, Liu L, Lai D, Grahame N, Flint J, Li TK, Lumeng L, Foroud T. PMID: 19120064; PMCID: PMC2867232.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    124. Applying mouse complex-trait resources to behavioural genetics. Nature. 2008 Dec 11; 456(7223):724-7. Flint J, Mott R. PMID: 19079048.
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    125. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res. 2009 Jan; 19(1):150-8. Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, Gulko PS, Brenner M, Tobeña A, Guitart-Masip M, Giménez-Llort L, Dominiczak A, Holmdahl R, Gauguier D, Olsson T, Mott R, Valdar W, Redei EE, Fernández-Teruel A, Flint J. PMID: 18971309; PMCID: PMC2612958.
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    126. Animal models of psychiatric disease. Curr Opin Genet Dev. 2008 Jun; 18(3):235-40. Flint J, Shifman S. PMID: 18657615.
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    127. Forum: Interactions between gene and environment. Curr Opin Psychiatry. 2008 Jul; 21(4):315-7. Flint J, Munafò MR. PMID: 18520729.
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    128. Prospects for complex trait analysis in the mouse. Mamm Genome. 2008 May; 19(5):306-8. Mott R, Flint J. PMID: 18493822; PMCID: PMC2515547.
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    129. Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. Biol Psychiatry. 2008 May 01; 63(9):874-83. Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J. PMID: 18083140.
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    130. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet. 2008 Feb; 4(2):e28. Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, Kendler KS, Li T, O'Donovan M, O'Neill FA, Owen MJ, Walsh D, Weinberger DR, Sun C, Flint J, Darvasi A. PMID: 18282107; PMCID: PMC2242812.
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    131. Genetic variants in major depression. Novartis Found Symp. 2008; 289:23-32; discussion 33-42, 87-93. Flint J, Shifman S, Munafo M, Mott R. PMID: 18497093.
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    132. Management, presentation and interpretation of genome scans using GSCANDB. Bioinformatics. 2007 Jun 15; 23(12):1545-9. Taylor M, Valdar W, Kumar A, Flint J, Mott R. PMID: 17400728.
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    133. Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell. 2007 Jan 12; 128(1):45-57. Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z, Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, Flint J. PMID: 17218254; PMCID: PMC1885944.
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    134. A high-resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biol. 2006 Nov; 4(12):e395. Shifman S, Bell JT, Copley RR, Taylor MS, Williams RW, Mott R, Flint J. PMID: 17105354; PMCID: PMC1635748.
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    135. Identifying the genetic determinants of emotionality in humans; insights from rodents. Neurosci Biobehav Rev. 2007; 31(1):115-24. Willis-Owen SA, Flint J. PMID: 17010437.
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    136. The endophenotype concept in psychiatric genetics. Psychol Med. 2007 Feb; 37(2):163-80. Flint J, Munafò MR. PMID: 16978446; PMCID: PMC2829981.
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    137. Genetic and environmental effects on complex traits in mice. Genetics. 2006 Oct; 174(2):959-84. Valdar W, Solberg LC, Gauguier D, Cookson WO, Rawlins JN, Mott R, Flint J. PMID: 16888333; PMCID: PMC1602068.
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    138. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet. 2006 Aug; 38(8):879-87. Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J. PMID: 16832355.
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    139. The genetic basis of emotional behaviour in mice. Eur J Hum Genet. 2006 Jun; 14(6):721-8. Willis-Owen SA, Flint J. PMID: 16721408.
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    140. Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens. Mamm Genome. 2006 Mar; 17(3):230-8. Keays DA, Clark TG, Flint J. PMID: 16518690.
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    141. A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mamm Genome. 2006 Feb; 17(2):129-46. Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Burnett S, Arboledas-Hita C, Hernandez-Pliego P, Davidson S, Burns P, Bhattacharya S, Hough T, Higgs D, Klenerman P, Cookson WO, Zhang Y, Deacon RM, Rawlins JN, Mott R, Flint J. PMID: 16465593.
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    142. Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice. Genetics. 2006 Mar; 172(3):1783-97. Valdar W, Flint J, Mott R. PMID: 16361245; PMCID: PMC1456308.
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    143. The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. Biol Psychiatry. 2005 Nov 01; 58(9):738-42. Willis-Owen SA, Fullerton J, Surtees PG, Wainwright NW, Miller S, Flint J. PMID: 16043130.
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    144. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry. 2005 Sep 15; 58(6):451-6. Willis-Owen SA, Turri MG, Munafò MR, Surtees PG, Wainwright NW, Brixey RD, Flint J. PMID: 16023085.
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    145. SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data. Nucleic Acids Res. 2005; 33(11):3455-64. Price TS, Regan R, Mott R, Hedman A, Honey B, Daniels RJ, Smith L, Greenfield A, Tiganescu A, Buckle V, Ventress N, Ayyub H, Salhan A, Pedraza-Diaz S, Broxholme J, Ragoussis J, Higgs DR, Flint J, Knight SJ. PMID: 15961730; PMCID: PMC1151590.
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    146. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet. 2005 Apr; 6(4):271-86. Flint J, Valdar W, Shifman S, Mott R. PMID: 15803197.
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    147. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet. 2004 Nov; 36(11):1197-202. Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. PMID: 15489855.
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    148. The genetic basis of neuroticism. Neurosci Biobehav Rev. 2004 May; 28(3):307-16. Flint J. PMID: 15225973.
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    149. Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice. Mamm Genome. 2004 Feb; 15(2):69-76. Turri MG, DeFries JC, Henderson ND, Flint J. PMID: 15058378.
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    150. Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice. Mamm Genome. 2004 Feb; 15(2):77-82. Flint J, DeFries JC, Henderson ND. PMID: 15058379.
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    151. The use of subtelomeric probes to study mental retardation. Methods Cell Biol. 2004; 75:799-831. Knight SJ, Flint J. PMID: 15603454.
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    152. QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks. Mamm Genome. 2003 Dec; 14(12):830-8. Valdar WS, Flint J, Mott R. PMID: 14724734.
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    153. A strategy for the integration of QTL, gene expression, and sequence analyses. Mamm Genome. 2003 Nov; 14(11):733-47. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Gensler B, Burgers S, Williams RW, Manly K, Flint J, Talbot C. PMID: 14722723.
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    154. The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet. 2003 Nov; 4(11):911-6. Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F, Complex Trait Consortium. PMID: 14634638; PMCID: PMC2063446.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimals
    155. The use of telomere probes to investigate submicroscopic rearrangements associated with mental retardation. Curr Opin Genet Dev. 2003 Jun; 13(3):310-6. Flint J, Knight S. PMID: 12787795.
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    156. Genetic mapping of variation in spatial learning in the mouse. J Neurosci. 2003 Mar 15; 23(6):2426-33. Steinberger D, Reynolds DS, Ferris P, Lincoln R, Datta S, Stanley J, Paterson A, Dawson GR, Flint J. PMID: 12657702; PMCID: PMC6742017.
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    157. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet. 2003 Apr; 72(4):879-90. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Fairburn C, Goodwin G, Neale MC, Fiddy S, Mott R, Allison DB, Flint J. PMID: 12612864; PMCID: PMC1180351.
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    158. Animal models of anxiety and their molecular dissection. Semin Cell Dev Biol. 2003 Feb; 14(1):37-42. Flint J. PMID: 12524005.
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    159. Analysis of quantitative trait loci that influence animal behavior. J Neurobiol. 2003 Jan; 54(1):46-77. Flint J. PMID: 12486698.
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    160. Genetic effects on an animal model of anxiety. FEBS Lett. 2002 Oct 02; 529(1):131-4. Flint J. PMID: 12354625.
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    161. Simultaneous detection and fine mapping of quantitative trait loci in mice using heterogeneous stocks. Genetics. 2002 Apr; 160(4):1609-18. Mott R, Flint J. PMID: 11973314; PMCID: PMC1462050.
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    162. A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res. 2002 Apr; 12(4):618-26. Fernández-Teruel A, Escorihuela RM, Gray JA, Aguilar R, Gil L, Giménez-Llort L, Tobeña A, Bhomra A, Nicod A, Mott R, Driscoll P, Dawson GR, Flint J. PMID: 11932246; PMCID: PMC187519.
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