Julia Jeannine Mack

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity. Proc Natl Acad Sci U S A. 2026 Jun 30; 123(26):e2519708123. Swaminathan A, Gonzalez DG, Matte-Martone C, Xu F, Simpson D, Moore JL, Lin Z, Rana U, Monedero-Alonso D, Mack JJ, Kam CY, Greco V. PMID: 42335226; PMCID: PMC13320711.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Regional heterogeneity and sex differences along the mouse aorta. Am J Physiol Heart Circ Physiol. 2026 Aug 01; 331(2):H384-H406. Sveeggen TM, Kosmach A, Mitchell R, Brockmann BC, Meisinger TM, Stratman AN, Mack JJ, Cook JR, Bagher P. PMID: 42267937.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease. Nat Aging. 2026 Apr; 6(4):792-815. Salladay-Perez IA, Avila I, Estrada L, Alexandru AC, Ponce C, Dhingra A, Torres G, Deng CY, Hegde R, Gensheimer J, Kale A, Heckenbach I, Hui S, Edillor C, Soto JA, Napior AJ, Little I, Larsen M, Rose J, Farahi L, Lopez Gonzalez EDJ, Krieger MR, Chowdhury K, Sharma M, Jiang Y, Williams K, Scheibye-Knudsen M, Koehler CM, Meyer JG, Mack JJ, Brenner C, Bensinger SJ, Lagger C, de Magalhães JP, Schilling B, Singh R, Verdin E, Lusis AJ, Covarrubias AJ. PMID: 41991686; PMCID: PMC13099426.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity. bioRxiv. 2026 Mar 06. Swaminathan A, Gonzalez DG, Matte-Martone C, Xu F, Simpson D, Moore JL, Lin Z, Rana U, Monedero-Alonso D, Mack JJ, Kam CY, Greco V. PMID: 40894686; PMCID: PMC12393453.
      View in: PubMed   Mentions:
    5. Photosensitizer proximity labeling captures the lipid and protein interactomes. Nat Chem Biol. 2026 Feb 06. Becker AP, Biletch E, Kennelly JP, Hong SG, Julio AR, Villanueva M, Nagari RT, Turner DW, Burton NR, Fukuta T, Cui L, Xiao X, Vellani Z, Nguyen A, Mack JJ, Tontonoz P, Backus KM. PMID: 41652064.
      View in: PubMed   Mentions: 1     Fields:    
    6. Adipose tissue releases nucleosides. Am J Physiol Cell Physiol. 2026 01 01; 330(1):C142-C154. Zhang J, Le T, Ruiz-Torres V, Cohen M, Paharkova V, Abt E, Alnajjar HS, Tan J, Rashid K, Jones AE, Ball AB, Divakaruni AS, Paszkiewicz RL, Bandaru P, Mack JJ, Ashby JW, Kim J, Li G, Radu CG, Mittelman SD. PMID: 41269663; PMCID: PMC12742186.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Adipose tissue explant culture using PDMS flow chambers: an alternative to static explant culture. Adipocyte. 2025 12; 14(1):2578286. Cohen M, Bandaru P, Szylo K, Nguyen N, Nadeak B, Paszkiewicz R, Ashby JW, Mack JJ, Tanaka L, Tan J, Khademhosseini A, Mittelman SD. PMID: 41132053; PMCID: PMC12562731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. T cell cholesterol transport links intestinal immune responses to dietary lipid absorption. Science. 2025 Oct 09; 390(6769):eadt4169. Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen A, Srikanth S, Weston T, Uchiyama LF, Cohn W, Cho DH, Lee MS, Whitelegge J, Gwack Y, Young SG, Bensinger SJ, Tontonoz P. PMID: 41066556; PMCID: PMC13034976.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. NAD Metabolism Regulates Proliferation of Macrophages in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2025 11; 45(11):1997-2014. Sinha SK, Swichkow CR, Farahi L, Péterfy M, Pan C, Zhou Z, Seldin MM, Mack JJ, Davis RC, Shih DM, Lusis AJ. PMID: 40931836; PMCID: PMC12614180.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Dietary control of peripheral adipose storage capacity through membrane lipid remodelling. Nat Metab. 2025 Jul; 7(7):1424-1442. Tol MJ, Shimanaka Y, Bedard AH, Sapia J, Cui L, Colaço-Gaspar M, Hofer P, Ferrari A, Qian K, Kennelly JP, Lee SD, Gao Y, Xiao X, Gao J, Mack JJ, Weston TA, Williams KJ, Su B, Pan C, Lusis AJ, Pike DP, Reed A, Milosevich N, Cravatt BF, Arita M, Young SG, Ford DA, Zechner R, Vanni S, Tontonoz P. PMID: 40579620.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Editorial: Mechanotransduction in vascular development and disease. Front Physiol. 2024; 15:1525184. Baeyens N, Coon BG, Mack JJ. PMID: 39720312; PMCID: PMC11666544.
      View in: PubMed   Mentions: 2  
    12. PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity. Cell Rep. 2024 12 24; 43(12):114945. De Siqueira MK, Li G, Zhao Y, Wang S, Ahn IS, Tamboline M, Hildreth AD, Larios J, Schcolnik-Cabrera A, Nouhi Z, Zhang Z, Tol MJ, Pandey V, Xu S, O'Sullivan TE, Mack JJ, Tontonoz P, Sallam T, Wohlschlegel JA, Hulea L, Xiao X, Yang X, Villanueva CJ. PMID: 39579770; PMCID: PMC12002411.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. Dietary control of peripheral adipose storage capacity through membrane lipid remodelling. bioRxiv. 2024 Oct 29. Tol MJ, Shimanaka Y, Bedard AH, Sapia J, Cui L, Colaço-Gaspar M, Hofer P, Ferrari A, Qian K, Kennelly JP, Lee SD, Gao Y, Xiao X, Gao J, Mack JJ, Weston TA, Pan C, Lusis AJ, Williams KJ, Su B, Pike DP, Reed A, Milosevich N, Cravatt BF, Arita M, Young SG, Ford DA, Zechner R, Vanni S, Tontonoz P. PMID: 39554041; PMCID: PMC11565995.
      View in: PubMed   Mentions:
    14. Cholesterol binding to VCAM-1 promotes vascular inflammation. bioRxiv. 2024 Sep 18. Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P. PMID: 39345495; PMCID: PMC11429921.
      View in: PubMed   Mentions:
    15. Lipid- and protein-directed photosensitizer proximity labeling captures the cholesterol interactome. bioRxiv. 2024 Aug 24. Becker AP, Biletch E, Kennelly JP, Julio AR, Villaneuva M, Nagari RT, Turner DW, Burton NR, Fukuta T, Cui L, Xiao X, Hong SG, Mack JJ, Tontonoz P, Backus KM. PMID: 39229057; PMCID: PMC11370482.
      View in: PubMed   Mentions:
    16. The transcriptional repressor B cell lymphoma 6 regulates CXCR3 chemokine and human leukocyte antigen II expression in endothelial cells. Am J Transplant. 2024 Dec; 24(12):2157-2173. Franco Acevedo A, Mack JJ, Valenzuela NM. PMID: 39074669.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Flow-mediated modulation of the endothelial cell lipidome. Front Physiol. 2024; 15:1431847. Hong SG, Kennelly JP, Williams KJ, Bensinger SJ, Mack JJ. PMID: 39119214; PMCID: PMC11307263.
      View in: PubMed   Mentions: 2  
    18. Flow-Mediated Modulation of the Endothelial Cell Lipidome. bioRxiv. 2024 Jun 15. Hong SG, Kennelly JP, Williams KJ, Bensinger SJ, Mack JJ. PMID: 38915541; PMCID: PMC11195170.
      View in: PubMed   Mentions:
    19. Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation. J Clin Invest. 2024 May 21; 134(13). Hong SG, Ashby JW, Kennelly JP, Wu M, Steel M, Chattopadhyay E, Foreman R, Tontonoz P, Tarling EJ, Turowski P, Gallagher-Jones M, Mack JJ. PMID: 38771648; PMCID: PMC11213468.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption. bioRxiv. 2024 Mar 11. Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young SG, Bensinger SJ, Tontonoz P. PMID: 38559079; PMCID: PMC10979874.
      View in: PubMed   Mentions:
    21. Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites. Sci Adv. 2024 02 16; 10(7):eadj7481. Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner J, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK. PMID: 38354249; PMCID: PMC10866565.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    22. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023 11 10; 382(6671):eadf0966. Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. PMID: 37943936; PMCID: PMC11073449.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    23. Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake. bioRxiv. 2023 Jul 10. Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. PMID: 37503112; PMCID: PMC10369906.
      View in: PubMed   Mentions: 1  
    24. Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation. bioRxiv. 2023 May 26. Hong SG, Ashby JW, Kennelly JP, Wu M, Chattopadhyay E, Foreman R, Tontonoz P, Turowski P, Gallagher-Jones M, Mack JJ. PMID: 37292837; PMCID: PMC10246006.
      View in: PubMed   Mentions:
    25. Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites. bioRxiv. 2023 May 03. Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner JA, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK. PMID: 37205360; PMCID: PMC10187200.
      View in: PubMed   Mentions: 1  
    26. New insights into maladaptive vascular responses to donor specific HLA antibodies in organ transplantation. Front Transplant. 2023; 2:1146040. Franco-Acevedo A, Comes J, Mack JJ, Valenzuela NM. PMID: 38993843; PMCID: PMC11235244.
      View in: PubMed   Mentions: 2  
    27. Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network. Front Cardiovasc Med. 2022; 9:841101. Baek KI, Chang SS, Chang CC, Roustaei M, Ding Y, Wang Y, Chen J, O'Donnell R, Chen H, Ashby JW, Xu X, Mack JJ, Cavallero S, Roper M, Hsiai TK. PMID: 35369301; PMCID: PMC8971683.
      View in: PubMed   Mentions: 6  
    28. Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial Repair. Cell Mol Gastroenterol Hepatol. 2022; 13(4):1095-1120. Meriwether D, Jones AE, Ashby JW, Solorzano-Vargas RS, Dorreh N, Noori S, Grijalva V, Ball AB, Semis M, Divakaruni AS, Mack JJ, Herschman HR, Martin MG, Fogelman AM, Reddy ST. PMID: 35017061; PMCID: PMC8873959.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    29. Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation. J Lipid Res. 2022 Jan; 63(1):100153. Mukherjee P, Chattopadhyay A, Grijalva V, Dorreh N, Lagishetty V, Jacobs JP, Clifford BL, Vallim T, Mack JJ, Navab M, Reddy ST, Fogelman AM. PMID: 34808192; PMCID: PMC8953663.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Mapping Cell Viability Quantitatively and Independently From Cell Density in 3D Gels Noninvasively. IEEE Trans Biomed Eng. 2021 10; 68(10):2940-2947. Archer BJ, Mack JJ, Acosta S, Nakasone R, Dahoud F, Youssef K, Goldstein A, Goldsman A, Held MC, Wiese M, Blumich B, Wessling M, Emondts M, Klankermayer J, Iruela-Arispe ML, Bouchard LS. PMID: 33531296; PMCID: PMC8326301.
      View in: PubMed   Mentions:    Fields:    
    31. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab. 2021 08 03; 33(8):1671-1684.e4. Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. PMID: 34270928; PMCID: PMC8353952.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimals
    32. Endothelial Control of Cerebral Blood Flow. Am J Pathol. 2021 11; 191(11):1906-1916. Ashby JW, Mack JJ. PMID: 33713686.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    33. Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities. Cell Stem Cell. 2018 Aug 02; 23(2):210-225.e6. McDonald AI, Shirali AS, Aragón R, Ma F, Hernandez G, Vaughn DA, Mack JJ, Lim TY, Sunshine H, Zhao P, Kalinichenko V, Hai T, Pelegrini M, Ardehali R, Iruela-Arispe ML. PMID: 30075129; PMCID: PMC6178982.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    34. Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI. IEEE Trans Biomed Eng. 2019 03; 66(3):821-830. Archer BJ, Uberruck T, Mack JJ, Youssef K, Jarenwattananon NN, Rall D, Wypysek D, Wiese M, Blumich B, Wessling M, Iruela-Arispe ML, Bouchard LS. PMID: 30028689; PMCID: PMC7811270.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    35. Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. Sci Rep. 2018 06 13; 8(1):9032. Chattopadhyay A, Yang X, Mukherjee P, Sulaiman D, Fogelman HR, Grijalva V, Dubinett S, Wasler TC, Paul MK, Salehi-Rad R, Mack JJ, Iruela-Arispe ML, Navab M, Fogelman AM, Reddy ST. PMID: 29899427; PMCID: PMC5998131.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    36. NOTCH regulation of the endothelial cell phenotype. Curr Opin Hematol. 2018 05; 25(3):212-218. Mack JJ, Iruela-Arispe ML. PMID: 29547401; PMCID: PMC5902133.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    37. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 11 20; 8(1):1620. Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. PMID: 29158473; PMCID: PMC5696341.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    38. Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model. J Vis Exp. 2016 11 24; (117). Shirali AS, McDonald AI, Mack JJ, Iruela-Arispe ML. PMID: 27911412; PMCID: PMC5226299.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    39. Perivascular Macrophages Limit Permeability. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2203-2212. He H, Mack JJ, Güç E, Warren CM, Squadrito ML, Kilarski WW, Baer C, Freshman RD, McDonald AI, Ziyad S, Swartz MA, De Palma M, Iruela-Arispe ML. PMID: 27634833; PMCID: PMC5083209.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    40. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. J Exp Med. 2015 Nov 16; 212(12):2147-63. Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML. PMID: 26552708; PMCID: PMC4647265.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    41. The SOLUTIONS project: challenges and responses for present and future emerging pollutants in land and water resources management. Sci Total Environ. 2015 Jan 15; 503-504:22-31. Brack W, Altenburger R, Schüürmann G, Krauss M, López Herráez D, van Gils J, Slobodnik J, Munthe J, Gawlik BM, van Wezel A, Schriks M, Hollender J, Tollefsen KE, Mekenyan O, Dimitrov S, Bunke D, Cousins I, Posthuma L, van den Brink PJ, López de Alda M, Barceló D, Faust M, Kortenkamp A, Scrimshaw M, Ignatova S, Engelen G, Massmann G, Lemkine G, Teodorovic I, Walz KH, Dulio V, Jonker MT, Jäger F, Chipman K, Falciani F, Liska I, Rooke D, Zhang X, Hollert H, Vrana B, Hilscherova K, Kramer K, Neumann S, Hammerbacher R, Backhaus T, Mack J, Segner H, Escher B, de Aragão Umbuzeiro G. PMID: 24951181.
      View in: PubMed   Mentions: 27     Fields:    Translation:PHPublic Health
    42. Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. Chembiochem. 2014 Jan 24; 15(2):233-42. Griffin DR, Borrajo J, Soon A, Acosta-Vélez GF, Oshita V, Darling N, Mack J, Barker T, Iruela-Arispe ML, Segura T. PMID: 24399784; PMCID: PMC4024472.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    43. Real-time maps of fluid flow fields in porous biomaterials. Biomaterials. 2013 Mar; 34(8):1980-6. Mack JJ, Youssef K, Noel OD, Lake MP, Wu A, Iruela-Arispe ML, Bouchard LS. PMID: 23245922; PMCID: PMC3714210.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    44. Enhanced cell viability via strain stimulus and fluid flow in magnetically actuated scaffolds. Biotechnol Bioeng. 2013 Mar; 110(3):936-46. Mack JJ, Corrin AA, dos Santos e Lucato SL, Dunn JC, Wu BW, Cox BN. PMID: 23042257.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor. Biotechnol Bioeng. 2012 Jul; 109(7):1844-54. Youssef K, Mack JJ, Iruela-Arispe ML, Bouchard LS. PMID: 22252902; PMCID: PMC8103415.
      View in: PubMed   Mentions: 6     Fields:    
    46. Enhanced solid-state metathesis routes to carbon nanotubes. Inorg Chem. 2006 May 15; 45(10):4243-6. Mack JJ, Tari S, Kaner RB. PMID: 16676987.
      View in: PubMed   Mentions: 1     Fields:    
    47. A chemical route to carbon nanoscrolls. Science. 2003 Feb 28; 299(5611):1361. Viculis LM, Mack JJ, Kaner RB. PMID: 12610297.
      View in: PubMed   Mentions: 44     Fields:    
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