Karen Marie Lyons

Title(s)Professor, Molecular, Cell and Developmental Biology
SchoolCollege of Letters and Science
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    Title(s)Professor, Orthopaedic Surgery


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    Title: BMP/TGFbeta crosstalk in cartilage maintenance and osteoarthritis
    NIH R01AR073793Jul 19, 2018 - Apr 30, 2024
    Role: Principal Investigator
    GP130/STAT3 signalling in articular cartilage development and regeneration
    NIH R01AR071734Apr 1, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Regulation of tendon development by CCN1/Cyr61
    NIH R21AR071728Mar 10, 2017 - Dec 31, 2019
    Role: Principal Investigator
    2011 Cartilage Biology &Pathology GRC
    NIH R13AR061167Mar 1, 2011 - Feb 29, 2012
    Role: Principal Investigator
    Regenerative Musculoskeletal Medicine Training Program
    NIH T32AR059033Apr 1, 2010 - Jul 31, 2026
    Role: Co-Principal Investigator
    CCN PROTEINS IN CARTILAGE FORMATION AND MAINTENANCE
    NIH R01AR052686Aug 20, 2005 - Jun 30, 2017
    Role: Principal Investigator
    BMP'S IN SKELETAL GROWTH AND OSTEOGENIC DIFFERENTIATION
    NIH R01AR044528Apr 1, 1998 - Mar 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Author Correction: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes. Commun Biol. 2022 Feb 25; 5(1):200. Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. PMID: 35217719; PMCID: PMC8881627.
      View in: PubMed   Mentions:
    2. gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes. Commun Biol. 2022 01 17; 5(1):64. Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. PMID: 35039652; PMCID: PMC8763901.
      View in: PubMed   Mentions: 2  Translation:AnimalsCells
    3. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging. Cell Stem Cell. 2021 06 03; 28(6):1057-1073.e7. Deng P, Yuan Q, Cheng Y, Li J, Liu Z, Liu Y, Li Y, Su T, Wang J, Salvo ME, Wang W, Fan G, Lyons K, Yu B, Wang CY. PMID: 33571444; PMCID: PMC8178178.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    4. Author Correction: NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2021 Jan 13; 12(1):453. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. PMID: 33441558; PMCID: PMC7806913.
      View in: PubMed   Mentions:    Fields:    
    5. CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH. J Bone Miner Res. 2020 11; 35(11):2289-2300. Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM. PMID: 32634285.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. TGFβ as a gatekeeper of BMP action in the developing growth plate. Bone. 2020 08; 137:115439. Wang W, Rigueur D, Lyons KM. PMID: 32442550; PMCID: PMC7891678.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15570-15579. Wang W, Chun H, Baek J, Sadik JE, Shirazyan A, Razavi P, Lopez N, Lyons KM. PMID: 31311865; PMCID: PMC6681752.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. BMPs, TGFβ, and border security at the interzone. Curr Top Dev Biol. 2019; 133:153-170. Lyons KM, Rosen V. PMID: 30902251.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. J Bone Miner Res. 2018 06; 33(6):1076-1089. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM. PMID: 29351359; PMCID: PMC6002906.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017 Jun 02; 356(6341). Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. PMID: 28572335; PMCID: PMC5567675.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    11. Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters. Methods Mol Biol. 2017; 1489:325-345. Jiang J, Hu Z, Lyons KM. PMID: 27734387.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct; 12(10):e1006352. Wang W, Song B, Anbarchian T, Shirazyan A, Sadik JE, Lyons KM. PMID: 27741240; PMCID: PMC5065210.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    13. TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions. PLoS Genet. 2016 Mar; 12(3):e1005936. Zieba J, Forlenza KN, Khatra JS, Sarukhanov A, Duran I, Rigueur D, Lyons KM, Cohn DH, Merrill AE, Krakow D. PMID: 27019229; PMCID: PMC4809497.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015 Jun 17; 6:7362. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. PMID: 26082355; PMCID: PMC4557288.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    15. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015 Apr; 30(4):733-41. Rigueur D, Brugger S, Anbarchian T, Kim JK, Lee Y, Lyons KM. PMID: 25413979; PMCID: PMC4376569.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    16. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22; 31(6):707-21. Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML. PMID: 25535917; PMCID: PMC4311887.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    17. GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways. J Bone Miner Res. 2014 Dec; 29(12):2676-87. Güemes M, Garcia AJ, Rigueur D, Runke S, Wang W, Zhao G, Mayorga VH, Atti E, Tetradis S, Péault B, Lyons K, Miranda-Carboni GA, Krum SA. PMID: 24932701; PMCID: PMC4501475.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Automated Cell Detection and Morphometry on Growth Plate Images of Mouse Bone. Appl Math (Irvine). 2014 Oct; 5(18):2866-2880. Ascenzi M, Du X, Harding JI, Beylerian EN, de Silva BM, Gross BJ, Kastein HK, Wang W, Lyons KM, Schaeffer H. PMID: 25525552; PMCID: PMC4267696.
      View in: PubMed   Mentions: 1  
    19. CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. J Biochem. 2015 Feb; 157(2):91-100. Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M. PMID: 25261584; PMCID: PMC6281389.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. TGFβ signaling in cartilage development and maintenance. Birth Defects Res C Embryo Today. 2014 Mar; 102(1):37-51. Wang W, Rigueur D, Lyons KM. PMID: 24677722; PMCID: PMC4267887.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    21. Whole-mount skeletal staining. Methods Mol Biol. 2014; 1130:113-121. Rigueur D, Lyons KM. PMID: 24482169; PMCID: PMC5384832.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    22. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. PMID: 24371811; PMCID: PMC3871393.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    23. Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15; 382(2):375-84. Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM. PMID: 23994637; PMCID: PMC4267888.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    24. CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. J Cell Commun Signal. 2013 Aug; 7(3):219-30. Hall-Glenn F, Aivazi A, Akopyan L, Ong JR, Baxter RR, Benya PD, Goldschmeding R, van Nieuwenhoven FA, Hunziker EB, Lyons KM. PMID: 23666466; PMCID: PMC3709047.
      View in: PubMed   Mentions: 14  
    25. Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet. 2012 Mar 09; 90(3):550-7. Merrill AE, Sarukhanov A, Krejci P, Idoni B, Camacho N, Estrada KD, Lyons KM, Deixler H, Robinson H, Chitayat D, Curry CJ, Lachman RS, Wilcox WR, Krakow D. PMID: 22387015; PMCID: PMC3309195.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    26. Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res. 2011 Oct; 26(10):2498-510. Estrada KD, Retting KN, Chin AM, Lyons KM. PMID: 21681813; PMCID: PMC3183270.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    27. Roles for CCN2 in normal physiological processes. Cell Mol Life Sci. 2011 Oct; 68(19):3209-17. Hall-Glenn F, Lyons KM. PMID: 21858450; PMCID: PMC3670951.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    28. Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization. J Theor Biol. 2011 Sep 21; 285(1):147-55. Ascenzi MG, Blanco C, Drayer I, Kim H, Wilson R, Retting KN, Lyons KM, Mohler G. PMID: 21723296; PMCID: PMC3163056.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    29. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60. Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. PMID: 20954177; PMCID: PMC3179327.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    30. Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res. 2010 Oct; 25(10):2138-47. Stevens JR, Miranda-Carboni GA, Singer MA, Brugger SM, Lyons KM, Lane TF. PMID: 20499361; PMCID: PMC3153316.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    31. Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem. 2010 Sep 03; 285(36):27702-12. Huang BL, Brugger SM, Lyons KM. PMID: 20571031; PMCID: PMC2934638.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):379-88. Song B, Estrada KD, Lyons KM. PMID: 19926329; PMCID: PMC2825570.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    33. Molecular regulation of limb growth. J Bone Joint Surg Am. 2009 Jul; 91 Suppl 4:47-52. Lyons K, Ezaki M. PMID: 19571067; PMCID: PMC2698795.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    34. BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development. 2009 Apr; 136(7):1093-104. Retting KN, Song B, Yoon BS, Lyons KM. PMID: 19224984; PMCID: PMC2668702.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    35. Fracture repair: challenges and opportunities. J Bone Joint Surg Am. 2008 Feb; 90 Suppl 1:1-2. Laurencin CT, Einhorn TA, Lyons K. PMID: 18292348.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. An AAOS-NIH symposium. Fracture repair: challenges, opportunities, and directions for future research. J Bone Joint Surg Am. 2008 Feb; 90(2):438-42. Einhorn TA, Laurencin CT, Lyons K. PMID: 18245605.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal. 2007 Jun; 1(1):45-58. Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. PMID: 18481209; PMCID: PMC2267656.
      View in: PubMed   Mentions: 46  
    38. The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity. J Cell Commun Signal. 2007 Jun; 1(1):17-32. Huang BL, Dornbach LM, Lyons KM. PMID: 18481207; PMCID: PMC2267653.
      View in: PubMed   Mentions: 6  
    39. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006 Dec; 133(23):4667-78. Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. PMID: 17065231.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    40. Tracking expression of virally mediated BMP-2 in gene therapy for bone repair. Clin Orthop Relat Res. 2006 Sep; 450:238-45. Gamradt SC, Abe N, Bahamonde ME, Lee YP, Nelson SD, Lyons KM, Lieberman JR. PMID: 16702923; PMCID: PMC4291079.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet. 2006 Apr 15; 15(8):1319-28. Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE. PMID: 16540516.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    42. BMP signaling in the cartilage growth plate. Curr Top Dev Biol. 2006; 76:1-48. Pogue R, Lyons K. PMID: 17118262.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    43. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 2005 Oct 14; 280(41):34796-804. Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. PMID: 16061471.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    44. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005 May; 132(10):2489-99. Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM. PMID: 15843411.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5062-7. Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. PMID: 15781876; PMCID: PMC555995.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
    46. Multiple functions of BMPs in chondrogenesis. J Cell Biochem. 2004 Sep 01; 93(1):93-103. Yoon BS, Lyons KM. PMID: 15352166.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    47. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J Biol Chem. 2004 Oct 29; 279(44):45980-9. Nakamura K, Kennedy MA, Baldán A, Bojanic DD, Lyons K, Edwards PA. PMID: 15319426.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    48. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun; 130(12):2779-91. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM. PMID: 12736220; PMCID: PMC3360973.
      View in: PubMed   Mentions: 287     Fields:    Translation:AnimalsCells
    49. BMP signaling is required for septation of the outflow tract of the mammalian heart. Development. 2003 Jan; 130(1):209-20. Délot EC, Bahamonde ME, Zhao M, Lyons KM. PMID: 12441304.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    50. ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med. 2003; 14(5):320-30. Nishimura I, Drake TA, Lusis AJ, Lyons KM, Nadeau JH, Zernik J. PMID: 14530301.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
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