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Lange Kenneth L.

Title(s)Maxine and Eugene Rosenfeld Professor of Computational Genetics, Human Genetics
Phone(310) 825-8685
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    Other Positions
    Title(s)Professor, Biomathematics

    Title(s)Professor, Statistics

    Title(s)Chair, Human Genetics


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liu CC, Shringarpure S, Lange K, Novembre J. Exploring Population Structure with Admixture Models and Principal Component Analysis. Methods Mol Biol. 2020; 2090:67-86. PMID: 31975164.
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    2. Keys KL, Zhou H, Lange K. Proximal Distance Algorithms: Theory and Practice. J Mach Learn Res. 2019 Apr; 20. PMID: 31649491.
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    3. Zhou H, Sinsheimer JS, Bates DM, Chu BB, German CA, Ji SS, Keys KL, Kim J, Ko S, Mosher GD, Papp JC, Sobel EM, Zhai J, Zhou JJ, Lange K. OPENMENDEL: a cooperative programming project for statistical genetics. Hum Genet. 2019 Mar 26. PMID: 30915546.
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    4. Zhou H, Hu L, Zhou J, Lange K. MM Algorithms For Variance Components Models. J Comput Graph Stat. 2019; 28(2):350-361. PMID: 31592195.
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    5. Chiu CY, Yuan F, Zhang BS, Yuan A, Li X, Fang HB, Lange K, Weeks DE, Wilson AF, Bailey-Wilson JE, Musolf AM, Stambolian D, Lakhal-Chaieb ML, Cook RJ, McMahon FJ, Amos CI, Xiong M, Fan R. Linear mixed models for association analysis of quantitative traits with next-generation sequencing data. Genet Epidemiol. 2019 03; 43(2):189-206. PMID: 30537345.
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    6. Landeros A, Stutz T, Keys KL, Alekseyenko A, Sinsheimer JS, Lange K, Sehl ME. BioSimulator.jl: Stochastic simulation in Julia. Comput Methods Programs Biomed. 2018 Dec; 167:23-35. PMID: 30501857.
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    7. Keys KL, Chen GK, Lange K. Iterative hard thresholding for model selection in genome-wide association studies. Genet Epidemiol. 2017 12; 41(8):756-768. PMID: 28875524.
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    8. Zhou H, Blangero J, Dyer TD, Chan KK, Lange K, Sobel EM. Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data. Genet Epidemiol. 2017 04; 41(3):174-186. PMID: 27943406.
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    9. Zhou H, Zhou J, Hu T, Sobel EM, Lange K. Genome-wide QTL and eQTL analyses using Mendel. BMC Proc. 2016; 10(Suppl 7):239-244. PMID: 27980643.
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    10. Shringarpure SS, Bustamante CD, Lange K, Alexander DH. Efficient analysis of large datasets and sex bias with ADMIXTURE. BMC Bioinformatics. 2016 May 23; 17:218. PMID: 27216439.
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    11. Crawford FW, Stutz TC, Lange K. Coupling bounds for approximating birth-death processes by truncation. Stat Probab Lett. 2016 Feb 01; 109:30-38. PMID: 26622074.
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    12. Chi EC, Lange K. Splitting Methods for Convex Clustering. J Comput Graph Stat. 2015; 24(4):994-1013. PMID: 27087770.
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    13. Wu TT, Lange K. Matrix Completion Discriminant Analysis. Comput Stat Data Anal. 2015 Dec; 92:115-125. PMID: 26549920.
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    14. Sehl ME, Shimada M, Landeros A, Lange K, Wicha MS. Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response. PLoS One. 2015; 10(9):e0135797. PMID: 26397099.
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    15. Shi H, Pasaniuc B, Lange KL. A multivariate Bernoulli model to predict DNaseI hypersensitivity status from haplotype data. Bioinformatics. 2015 Nov 01; 31(21):3514-21. PMID: 26139633.
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    16. Zhou H, Lange K. Path Following in the Exact Penalty Method of Convex Programming. Comput Optim Appl. 2015 Jul 01; 61(3):609-634. PMID: 26366044.
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    17. Chen GK, Chi EC, Ranola JM, Lange K. Convex clustering: an attractive alternative to hierarchical clustering. PLoS Comput Biol. 2015 May; 11(5):e1004228. PMID: 25965340.
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    18. Chi EC, Lange K. Stable Estimation of a Covariance Matrix Guided by Nuclear Norm Penalties. Comput Stat Data Anal. 2014 Dec 01; 80:117-128. PMID: 25143662.
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    19. Chi EC, Zhou H, Lange K. Distance majorization and its applications. Math Program. 2014 Aug 01; 146:409-436. PMID: 25392563.
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    20. Rañola JM, Novembre J, Lange K. Fast spatial ancestry via flexible allele frequency surfaces. Bioinformatics. 2014 Oct 15; 30(20):2915-22. PMID: 25012181.
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    21. Zhou H, Zhou J, Sobel EM, Lange K. Fast genome-wide pedigree quantitative trait loci analysis using MENDEL. BMC Proc. 2014; 8(Suppl 1):S93. PMID: 25519348.
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    22. Lange K, Chi EC, Zhou H. A Brief Survey of Modern Optimization for Statisticians. Int Stat Rev. 2014 Apr 01; 82(1):46-70. PMID: 25242858.
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    23. Lange K. Hadamard's Determinant Inequality. Am Math Mon. 2014 Mar 01; 121(3):258-259. PMID: 25284823.
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    24. Lange K, Zhou H. MM Algorithms for Geometric and Signomial Programming. Math Program. 2014 Feb 01; 143(1-2):339-356. PMID: 24634545.
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    25. Chi EC, Lange K. A Look at the Generalized Heron Problem through the Lens of Majorization-Minimization. Am Math Mon. 2014 Feb; 121(2):95-108. PMID: 25242816.
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    26. Lange K, Papp JC, Sinsheimer JS, Sobel EM. Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data. Annu Rev Stat Appl. 2014 Jan 01; 1(1):279-300. PMID: 24955378.
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    27. Chi EC, Allen GI, Zhou H, Kohannim O, Lange K, Thompson PM. IMAGING GENETICS VIA SPARSE CANONICAL CORRELATION ANALYSIS. Proc IEEE Int Symp Biomed Imaging. 2013 Dec 31; 2013:740-743. PMID: 24443689.
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    28. Lange K, Papp JC, Sinsheimer JS, Sripracha R, Zhou H, Sobel EM. Mendel: the Swiss army knife of genetic analysis programs. Bioinformatics. 2013 Jun 15; 29(12):1568-70. PMID: 23610370.
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    29. Ranola JM, Langfelder P, Lange K, Horvath S. Cluster and propensity based approximation of a network. BMC Syst Biol. 2013 Mar 14; 7:21. PMID: 23497424.
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    30. Zhou H, Lange K. A Path Algorithm for Constrained Estimation. J Comput Graph Stat. 2013; 22(2):261-283. PMID: 24039382.
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    31. Riley L, Zhou H, Lange K, Sinsheimer JS, Sehl ME. Determining duration of HER2-targeted therapy using stem cell extinction models. PLoS One. 2012; 7(12):e46613. PMID: 23284608.
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    32. Chi EC, Zhou H, Chen GK, Del Vecchyo DO, Lange K. Genotype imputation via matrix completion. Genome Res. 2013 Mar; 23(3):509-18. PMID: 23233546.
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    33. Chen GK, Wang K, Stram AH, Sobel EM, Lange K. Mendel-GPU: haplotyping and genotype imputation on graphics processing units. Bioinformatics. 2012 Nov 15; 28(22):2979-80. PMID: 22954633.
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    34. Zhang Z, Lange K, Sabatti C. Reconstructing DNA copy number by joint segmentation of multiple sequences. BMC Bioinformatics. 2012 Aug 16; 13:205. PMID: 22897923.
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    35. Zhou JJ, Ghazalpour A, Sobel EM, Sinsheimer JS, Lange K. Quantitative trait Loci association mapping by imputation of strain origins in multifounder crosses. Genetics. 2012 Feb; 190(2):459-73. PMID: 22143921.
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    36. Wang RT, Ahn S, Park CC, Khan AH, Lange K, Smith DJ. Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics. 2011 Nov 16; 12:562. PMID: 22085887.
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    37. Sehl M, Zhou H, Sinsheimer JS, Lange KL. Extinction models for cancer stem cell therapy. Math Biosci. 2011 Dec; 234(2):132-46. PMID: 22001354.
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    38. Alexander DH, Lange K. Stability selection for genome-wide association. Genet Epidemiol. 2011 Nov; 35(7):722-8. PMID: 22009793.
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    39. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. Unifying ideas for non-parametric linkage analysis. Hum Hered. 2011; 71(4):267-80. PMID: 21822022.
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    40. Alexander DH, Lange K. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics. 2011 Jun 18; 12:246. PMID: 21682921.
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    41. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. Linkage analysis without defined pedigrees. Genet Epidemiol. 2011 Jul; 35(5):360-70. PMID: 21465549.
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    42. Zhou H, Alexander D, Lange K. A quasi-Newton acceleration for high-dimensional optimization algorithms. Stat Comput. 2011 Jan 04; 21(2):261-273. PMID: 21359052.
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    43. Zhou H, Lange K. A Fast Procedure for Calculating Importance Weights in Bootstrap Sampling. Comput Stat Data Anal. 2011 Jan 01; 55(1):26-33. PMID: 21076658.
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    44. Zhang Z, Lange K, Ophoff R, Sabatti C. RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION. Ann Appl Stat. 2010 Dec 01; 4(4):1749-1773. PMID: 21572975.
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    45. Zhou H, Lange KL. On the Bumpy Road to the Dominant Mode. Scand Stat Theory Appl. 2010 Dec; 37(4):612-631. PMID: 21170287.
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    46. Zhou H, Lange K. MM Algorithms for Some Discrete Multivariate Distributions. J Comput Graph Stat. 2010 Sep 01; 19(3):645-665. PMID: 20877446.
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    47. Zhou H, Sehl ME, Sinsheimer JS, Lange K. Association screening of common and rare genetic variants by penalized regression. Bioinformatics. 2010 Oct 01; 26(19):2375-82. PMID: 20693321.
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    48. Zhou H, Lange K, Suchard MA. Graphics Processing Units and High-Dimensional Optimization. Stat Sci. 2010 Aug 01; 25(3):311-324. PMID: 21847315.
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    49. Childs EJ, Palmer CG, Lange K, Sinsheimer JS. Modeling maternal-offspring gene-gene interactions: the extended-MFG test. Genet Epidemiol. 2010 Jul; 34(5):512-21. PMID: 20552637.
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    50. Ranola JM, Ahn S, Sehl M, Smith DJ, Lange K. A Poisson model for random multigraphs. Bioinformatics. 2010 Aug 15; 26(16):2004-11. PMID: 20554690.
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    51. Zhong M, Lange K, Papp JC, Fan R. A powerful score test to detect positive selection in genome-wide scans. Eur J Hum Genet. 2010 Oct; 18(10):1148-59. PMID: 20461112.
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    52. Gao MC, Bellugi U, Dai L, Mills DL, Sobel EM, Lange K, Korenberg JR. Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex. PLoS One. 2010 Apr 21; 5(4):e10292. PMID: 20422020.
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    53. Cantor RM, Lange K, Sinsheimer JS. Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am J Hum Genet. 2010 Jan; 86(1):6-22. PMID: 20074509.
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    54. Sehl ME, Sinsheimer JS, Zhou H, Lange KL. Differential destruction of stem cells: implications for targeted cancer stem cell therapy. Cancer Res. 2009 Dec 15; 69(24):9481-9. PMID: 19996291.
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    55. Zhou H, Lange K. Rating Movies and Rating the Raters Who Rate Them. Am Stat. 2009 Nov 01; 63(4):297-307. PMID: 20802818.
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    56. Sehl M, Alekseyenko AV, Lange KL. Accurate stochastic simulation via the step anticipation tau-leaping (SAL) algorithm. J Comput Biol. 2009 Sep; 16(9):1195-208. PMID: 19772431.
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    57. Alexander DH, Novembre J, Lange K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009 Sep; 19(9):1655-64. PMID: 19648217.
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    58. Ahn S, Wang RT, Park CC, Lin A, Leahy RM, Lange K, Smith DJ. Directed mammalian gene regulatory networks using expression and comparative genomic hybridization microarray data from radiation hybrids. PLoS Comput Biol. 2009 Jun; 5(6):e1000407. PMID: 19521529.
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    59. de Leeuw J, Lange K. Sharp Quadratic Majorization in One Dimension. Comput Stat Data Anal. 2009 May 15; 53(7):2471-2484. PMID: 21738282.
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    60. Zhou JJ, Lange K, Papp JC, Sinsheimer JS. A heterozygote-homozygote test of Hardy-Weinberg equilibrium. Eur J Hum Genet. 2009 Nov; 17(11):1495-500. PMID: 19367317.
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    61. Wu TT, Chen YF, Hastie T, Sobel E, Lange K. Genome-wide association analysis by lasso penalized logistic regression. Bioinformatics. 2009 Mar 15; 25(6):714-21. PMID: 19176549.
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    62. Bauman LE, Sinsheimer JS, Sobel EM, Lange K. Mixed effects models for quantitative trait loci mapping with inbred strains. Genetics. 2008 Nov; 180(3):1743-61. PMID: 18791243.
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    63. Ayers KL, Lange K. Penalized estimation of haplotype frequencies. Bioinformatics. 2008 Jul 15; 24(14):1596-602. PMID: 18487240.
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    64. Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet. 2008 Apr; 40(4):421-9. PMID: 18362883.
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    65. Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K. Estimating ethnic admixture from pedigree data. Am J Hum Genet. 2008 Mar; 82(3):748-55. PMID: 18319077.
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    66. Sabatti C, Lange K. Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays. J Am Stat Assoc. 2008 03 01; 103(481):89-100. PMID: 21572926.
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    67. Ayers KL, Sabatti C, Lange K. A dictionary model for haplotyping, genotype calling, and association testing. Genet Epidemiol. 2007 Nov; 31(7):672-83. PMID: 17487885.
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    68. Lange K, Sobel E. Variance component models for X-linked QTLs. Genet Epidemiol. 2006 Jul; 30(5):380-3. PMID: 16671110.
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    69. Presson AP, Sobel E, Lange K, Papp JC. Merging microsatellite data. J Comput Biol. 2006 Jul-Aug; 13(6):1131-47. PMID: 16901233.
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    70. Chen GK, Slaten E, Ophoff RA, Lange K. Accommodating chromosome inversions in linkage analysis. Am J Hum Genet. 2006 Aug; 79(2):238-51. PMID: 16826515.
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    71. Ayers KL, Sabatti C, Lange K. Reconstructing ancestral haplotypes with a dictionary model. J Comput Biol. 2006 Apr; 13(3):767-85. PMID: 16706724.
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    72. Greenawalt DM, Cui X, Wu Y, Lin Y, Wang HY, Luo M, Tereshchenko IV, Hu G, Li JY, Chu Y, Azaro MA, Decoste CJ, Chimge NO, Gao R, Shen L, Shih WJ, Lange K, Li H. Strong correlation between meiotic crossovers and haplotype structure in a 2.5-Mb region on the long arm of chromosome 21. Genome Res. 2006 Feb; 16(2):208-14. PMID: 16385099.
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    73. Lange K, Sinsheimer JS, Sobel E. Association testing with Mendel. Genet Epidemiol. 2005 Jul; 29(1):36-50. PMID: 15834862.
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    74. Cantor RM, Chen GK, Pajukanta P, Lange K. Association testing in a linked region using large pedigrees. Am J Hum Genet. 2005 Mar; 76(3):538-42. PMID: 15657872.
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    75. Sabatti C, Rohlin L, Lange K, Liao JC. Vocabulon: a dictionary model approach for reconstruction and localization of transcription factor binding sites. Bioinformatics. 2005 Apr 01; 21(7):922-31. PMID: 15509602.
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    76. Lilja HE, Suviolahti E, Soro-Paavonen A, Hiekkalinna T, Day A, Lange K, Sobel E, Taskinen MR, Peltonen L, Perola M, Pajukanta P. Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia. J Lipid Res. 2004 Oct; 45(10):1876-84. PMID: 15258200.
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    77. Lange EM, Lange K. Powerful allele sharing statistics for nonparametric linkage analysis. Hum Hered. 2004; 57(1):49-58. PMID: 15133312.
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    78. Lange K, Sinsheimer JS. The pedigree trimming problem. Hum Hered. 2004; 58(2):108-11. PMID: 15711090.
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    79. Schadt E, Lange K. Codon and rate variation models in molecular phylogeny. Mol Biol Evol. 2002 Sep; 19(9):1534-49. PMID: 12200481.
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    80. Schadt EE, Sinsheimer JS, Lange K. Applications of codon and rate variation models in molecular phylogeny. Mol Biol Evol. 2002 Sep; 19(9):1550-62. PMID: 12200482.
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    81. Ro KM, Cantor RM, Lange KL, Ahn SS. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg. 2002 Feb; 35(2):382-6. PMID: 11854739.
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    82. Sobel E, Papp JC, Lange K. Detection and integration of genotyping errors in statistical genetics. Am J Hum Genet. 2002 Feb; 70(2):496-508. PMID: 11791215.
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    83. Berloff N, Perola M, Lange K. Spline methods for the comparison of physical and genetic maps. J Comput Biol. 2002; 9(3):465-75. PMID: 12162886.
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