Kent L Hill

Title(s)Professor, MIMG
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    Social Motility and cAMP signaling in chemotaxis and parasite-vector interactions of African trypanosomes
    NIH R21AI142544Jan 17, 2019 - Dec 31, 2020
    Role: Principal Investigator
    Social Motility and inter-kingdom interactions in African trypanosomes
    NIH R21AI133166May 15, 2018 - Apr 30, 2021
    Role: Principal Investigator
    Host-specific cell surface receptors on African trypanosomes
    NIH R21AI094333Mar 1, 2012 - Feb 28, 2015
    Role: Principal Investigator
    Biochemical and Functional Analysis of Trypanin
    NIH R01AI052348Jun 1, 2002 - Jun 30, 2024
    Role: Principal Investigator
    Biochemical and Functional Analysis of Trypanin
    NIH R56AI052348Jun 1, 2002 - Dec 14, 2008
    Role: Principal Investigator
    NIH K22AI001762Jul 1, 2001 - Jun 30, 2003
    Role: Principal Investigator
    NIH F32AI009872Nov 30, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Author Correction: Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Cell Discov. 2021 Aug 06; 7(1):61. Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. PMID: 34362876; PMCID: PMC8346584.
      View in: PubMed   Mentions:
    2. Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Cell Discov. 2021 Jul 13; 7(1):51. Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. PMID: 34257277; PMCID: PMC8277818.
      View in: PubMed   Mentions: 5  
    3. Right place, right time: Environmental sensing and signal transduction directs cellular differentiation and motility in Trypanosoma brucei. Mol Microbiol. 2021 05; 115(5):930-941. Walsh B, Hill KL. PMID: 33434370; PMCID: PMC8405151.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei. mSphere. 2021 02 10; 6(1). Vélez-Ramírez DE, Shimogawa MM, Ray SS, Lopez A, Rayatpisheh S, Langousis G, Gallagher-Jones M, Dean S, Wohlschlegel JA, Hill KL. PMID: 33568455; PMCID: PMC8141408.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. Identification of Positive Chemotaxis in the Protozoan Pathogen Trypanosoma brucei. mSphere. 2020 08 12; 5(4). DeMarco SF, Saada EA, Lopez MA, Hill KL. PMID: 32817459; PMCID: PMC7426175.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei. Elife. 2019 11 11; 8. Imhof S, Zhang J, Wang H, Bui KH, Nguyen H, Atanasov I, Hui WH, Yang SK, Zhou ZH, Hill KL. PMID: 31710293; PMCID: PMC6974359.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    7. Flagellar cAMP signaling controls trypanosome progression through host tissues. Nat Commun. 2019 02 18; 10(1):803. Shaw S, DeMarco SF, Rehmann R, Wenzler T, Florini F, Roditi I, Hill KL. PMID: 30778051; PMCID: PMC6379439.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    8. Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning. Light Sci Appl. 2018; 7:108. Zhang Y, Ceylan Koydemir H, Shimogawa MM, Yalcin S, Guziak A, Liu T, Oguz I, Huang Y, Bai B, Luo Y, Luo Y, Wei Z, Wang H, Bianco V, Zhang B, Nadkarni R, Hill K, Ozcan A. PMID: 30564314; PMCID: PMC6290798.
      View in: PubMed   Mentions: 20  
    9. Parasite motility is critical for virulence of African trypanosomes. Sci Rep. 2018 06 14; 8(1):9122. Shimogawa MM, Ray SS, Kisalu N, Zhang Y, Geng Q, Ozcan A, Hill KL. PMID: 29904094; PMCID: PMC6002391.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    10. Sensing and signaling in parasitism. Mol Biochem Parasitol. 2016 07; 208(1):1. Marti M, Hill KL. PMID: 27546054; PMCID: PMC5208041.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):632-7. Langousis G, Shimogawa MM, Saada EA, Vashisht AA, Spreafico R, Nager AR, Barshop WD, Nachury MV, Wohlschlegel JA, Hill KL. PMID: 26721397; PMCID: PMC4725476.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    12. "With a Little Help from My Friends"-Social Motility in Trypanosoma brucei. PLoS Pathog. 2015 Dec; 11(12):e1005272. Saada EA, DeMarco SF, Shimogawa MM, Hill KL. PMID: 26679190; PMCID: PMC4683075.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    13. Cell Surface Proteomics Provides Insight into Stage-Specific Remodeling of the Host-Parasite Interface in Trypanosoma brucei. Mol Cell Proteomics. 2015 Jul; 14(7):1977-88. Shimogawa MM, Saada EA, Vashisht AA, Barshop WD, Wohlschlegel JA, Hill KL. PMID: 25963835; PMCID: PMC4587323.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Cyclic AMP Regulates Social Behavior in African Trypanosomes. mBio. 2015 Apr 28; 6(3):e01954-14. Oberholzer M, Saada EA, Hill KL. PMID: 25922395; PMCID: PMC4436052.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    15. Insect stage-specific adenylate cyclases regulate social motility in African trypanosomes. Eukaryot Cell. 2015 Jan; 14(1):104-12. Lopez MA, Saada EA, Hill KL. PMID: 25416239; PMCID: PMC4279026.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    16. Motility and more: the flagellum of Trypanosoma brucei. Nat Rev Microbiol. 2014 Jul; 12(7):505-18. Langousis G, Hill KL. PMID: 24931043; PMCID: PMC4278896.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei. RNA. 2014 Aug; 20(8):1272-86. Freire ER, Vashisht AA, Malvezzi AM, Zuberek J, Langousis G, Saada EA, Nascimento Jde F, Stepinski J, Darzynkiewicz E, Hill K, De Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. PMID: 24962368; PMCID: PMC4105752.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    18. Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane. Eukaryot Cell. 2014 Aug; 13(8):1064-76. Saada EA, Kabututu ZP, Lopez M, Shimogawa MM, Langousis G, Oberholzer M, Riestra A, Jonsson ZO, Wohlschlegel JA, Hill KL. PMID: 24879126; PMCID: PMC4135804.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    19. Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog. Eukaryot Cell. 2014 Jul; 13(7):896-908. Freire ER, Malvezzi AM, Vashisht AA, Zuberek J, Saada EA, Langousis G, Nascimento JD, Moura D, Darzynkiewicz E, Hill K, de Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. PMID: 24839125; PMCID: PMC4135740.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    20. Mouse infection and pathogenesis by Trypanosoma brucei motility mutants. Cell Microbiol. 2014 Jun; 16(6):912-24. Kisalu NK, Langousis G, Bentolila LA, Ralston KS, Hill KL. PMID: 24286532; PMCID: PMC4264834.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    21. CMF22 is a broadly conserved axonemal protein and is required for propulsive motility in Trypanosoma brucei. Eukaryot Cell. 2013 Sep; 12(9):1202-13. Nguyen HT, Sandhu J, Langousis G, Hill KL. PMID: 23851336; PMCID: PMC3811564.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    22. Fluid flows and forces in development: functions, features and biophysical principles. Development. 2012 Apr; 139(7):1229-45. Freund JB, Goetz JG, Hill KL, Vermot J. PMID: 22395739; PMCID: PMC3294433.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    23. Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. PLoS One. 2012; 7(1):e25700. Hughes LC, Ralston KS, Hill KL, Zhou ZH. PMID: 22235240; PMCID: PMC3250385.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    24. Social parasites. Curr Opin Microbiol. 2011 Dec; 14(6):642-8. Lopez MA, Nguyen HT, Oberholzer M, Hill KL. PMID: 22020108; PMCID: PMC3230740.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    25. Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei. Mol Cell Proteomics. 2011 Oct; 10(10):M111.010538. Oberholzer M, Langousis G, Nguyen HT, Saada EA, Shimogawa MM, Jonsson ZO, Nguyen SM, Wohlschlegel JA, Hill KL. PMID: 21685506; PMCID: PMC3205874.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    26. Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei. Eukaryot Cell. 2011 Jul; 10(7):884-94. Ralston KS, Kisalu NK, Hill KL. PMID: 21378260; PMCID: PMC3147417.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    27. CMF70 is a subunit of the dynein regulatory complex. J Cell Sci. 2010 Oct 15; 123(Pt 20):3587-95. Kabututu ZP, Thayer M, Melehani JH, Hill KL. PMID: 20876659; PMCID: PMC2951471.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    28. Parasites in motion: flagellum-driven cell motility in African trypanosomes. Curr Opin Microbiol. 2010 Aug; 13(4):459-65. Hill KL. PMID: 20591724; PMCID: PMC3225338.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Social motility in african trypanosomes. PLoS Pathog. 2010 Jan 29; 6(1):e1000739. Oberholzer M, Lopez MA, McLelland BT, Hill KL. PMID: 20126443; PMCID: PMC2813273.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    30. Approaches for functional analysis of flagellar proteins in African trypanosomes. Methods Cell Biol. 2009; 93:21-57. Oberholzer M, Lopez MA, Ralston KS, Hill KL. PMID: 20409810; PMCID: PMC3821762.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19322-7. Rodríguez JA, Lopez MA, Thayer MC, Zhao Y, Oberholzer M, Chang DD, Kisalu NK, Penichet ML, Helguera G, Bruinsma R, Hill KL, Miao J. PMID: 19880745; PMCID: PMC2780783.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    32. The Trypanosoma brucei flagellum: moving parasites in new directions. Annu Rev Microbiol. 2009; 63:335-62. Ralston KS, Kabututu ZP, Melehani JH, Oberholzer M, Hill KL. PMID: 19575562; PMCID: PMC3821760.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    33. The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature. 2009 Jan 08; 457(7226):205-9. Colantonio JR, Vermot J, Wu D, Langenbacher AD, Fraser S, Chen JN, Hill KL. PMID: 19043402; PMCID: PMC3821763.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    34. The flagellum of Trypanosoma brucei: new tricks from an old dog. Int J Parasitol. 2008 Jul; 38(8-9):869-84. Ralston KS, Hill KL. PMID: 18472102; PMCID: PMC3210513.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    35. Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. Cell Motil Cytoskeleton. 2007 Jun; 64(6):461-73. Bekker JM, Colantonio JR, Stephens AD, Clarke WT, King SJ, Hill KL, Crosbie RH. PMID: 17366626.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    36. Stuck in reverse: loss of LC1 in Trypanosoma brucei disrupts outer dynein arms and leads to reverse flagellar beat and backward movement. J Cell Sci. 2007 May 01; 120(Pt 9):1513-20. Baron DM, Kabututu ZP, Hill KL. PMID: 17405810.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    37. Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella. J Cell Sci. 2007 Feb 01; 120(Pt 3):478-91. Baron DM, Ralston KS, Kabututu ZP, Hill KL. PMID: 17227795.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    38. Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. PLoS Pathog. 2006 Sep; 2(9):e101. Ralston KS, Hill KL. PMID: 17009870; PMCID: PMC1579245.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    39. Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. Traffic. 2006 May; 7(5):538-48. Colantonio JR, Bekker JM, Kim SJ, Morrissey KM, Crosbie RH, Hill KL. PMID: 16643277.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    40. Flagellar motility contributes to cytokinesis in Trypanosoma brucei and is modulated by an evolutionarily conserved dynein regulatory system. Eukaryot Cell. 2006 Apr; 5(4):696-711. Ralston KS, Lerner AG, Diener DR, Hill KL. PMID: 16607017; PMCID: PMC1459671.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    41. Biology and mechanism of trypanosome cell motility. Eukaryot Cell. 2003 Apr; 2(2):200-8. Hill KL. PMID: 12684369; PMCID: PMC154846.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    42. Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes. J Cell Biol. 2002 Mar 04; 156(5):867-77. Hutchings NR, Donelson JE, Hill KL. PMID: 11864997; PMCID: PMC2173309.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
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