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Leonard H Rome

Title(s)Professor, Biological Chemistry
SchoolMedicine
Phone50789
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    Collapse Research 
    Collapse Research Activities and Funding
    Vault-CCL21 Nanocapsule for Lung Cancer
    NIH/NCI U44CA167593Sep 17, 2012 - Aug 31, 2017
    Role: Co-Principal Investigator
    Vaults as Nonviral Nucleic Acid Delivery Vehicles
    NIH/NIBIB R01EB004553May 1, 2005 - Feb 28, 2010
    Role: Principal Investigator
    Consortium for Enhancing Human Subject Research Oversite
    NIH/NCRR S07RR018236Sep 1, 2002 - Sep 14, 2003
    Role: Principal Investigator
    CONSTRUCTION OF MAGNETIC RESONNANCE CENTER
    NIH/NCRR C06RR017368May 1, 2002 - Apr 30, 2004
    Role: Principal Investigator
    Vaults as New Targets for Modulating Tumor Response
    NIH/NCI R21CA091145Apr 1, 2001 - Mar 31, 2004
    Role: Principal Investigator
    THE UCLA RESEARCH GROWTH CENTER
    NIH/NCRR C06RR015511Sep 30, 2000 - Sep 29, 2003
    Role: Principal Investigator
    CNS MYELINATION--ROLE OF AXOLEMMAL PROTEINS
    NIH/NINDS R01NS034265Aug 1, 1995 - May 31, 1999
    Role: Principal Investigator
    NOVEL CYTOPLASMIC LARGE RIBONUCLEOPROTEIN PARTICLE
    NIH/NIGMS R01GM038097Apr 1, 1987 - Sep 29, 1992
    Role: Principal Investigator
    MECHANISMS FOR THE CONTROL OF LYSOSOME FUNCTION
    NIH/NIGMS R01GM031565Jan 1, 1983 - Dec 31, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nagasawa DT, Yang J, Romiyo P, Lagman C, Chung LK, Voth BL, Duong C, Kickhoefer VA, Rome LH, Yang I. Bioengineered recombinant vault nanoparticles coupled with NY-ESO-1 glioma-associated antigens induce maturation of native dendritic cells. J Neurooncol. 2020 May 07. PMID: 32383063.
      View in: PubMed
    2. Voth BL, Pelargos PE, Barnette NE, Bhatt NS, Chen CHJ, Lagman C, Chung LK, Nguyen T, Sheppard JP, Romiyo P, Mareninov S, Kickhoefer VA, Yong WH, Rome LH, Yang I. Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma. J Neurooncol. 2020 Apr 09. PMID: 32274629.
      View in: PubMed
    3. Lothe AG, Kalra SS, Wang M, Mack EE, Walecka-Hutchison C, Kickhoefer VA, Rome LH, Mahendra S. Vault packaged enzyme mediated degradation of amino-aromatic energetic compounds. Chemosphere. 2020 Mar; 242:125117. PMID: 31655399.
      View in: PubMed
    4. Fulcher JA, Tamshen K, Wollenberg AL, Kickhoefer VA, Mrazek J, Elliott J, Ibarrondo FJ, Anton PA, Rome LH, Maynard HD, Deming T, Yang OO. Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. Bioconjug Chem. 2019 Aug 21; 30(8):2216-2227. PMID: 31265254.
      View in: PubMed
    5. Wang M, Kickhoefer VA, Rome LH, Foellmer OK, Mahendra S. Synthesis and assembly of human vault particles in yeast. Biotechnol Bioeng. 2018 12; 115(12):2941-2950. PMID: 30171681.
      View in: PubMed
    6. Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH. Solution Structures of Engineered Vault Particles. Structure. 2018 04 03; 26(4):619-626.e3. PMID: 29551289.
      View in: PubMed
    7. Wang M, Abad D, Kickhoefer VA, Rome LH, Mahendra S. Encapsulation of Exogenous Proteins in Vault Nanoparticles. Methods Mol Biol. 2018; 1798:25-37. PMID: 29868949.
      View in: PubMed
    8. Yu K, Yau YH, Sinha A, Tan T, Kickhoefer VA, Rome LH, Lee H, Shochat SG, Lim S. Modulation of the Vault Protein-Protein Interaction for Tuning of Molecular Release. Sci Rep. 2017 11 01; 7(1):14816. PMID: 29093465.
      View in: PubMed
    9. Jiang J, Liu G, Kickhoefer VA, Rome LH, Li LX, McSorley SJ, Kelly KA. A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant. Vaccines (Basel). 2017 Jan 19; 5(1). PMID: 28106821.
      View in: PubMed
    10. Benner NL, Zang X, Buehler DC, Kickhoefer VA, Rome ME, Rome LH, Wender PA. Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery. ACS Nano. 2017 01 24; 11(1):872-881. PMID: 28029784.
      View in: PubMed
    11. Wang M, Abad D, Kickhoefer VA, Rome LH, Mahendra S. Vault Nanoparticles Packaged with Enzymes as an Efficient Pollutant Biodegradation Technology. ACS Nano. 2015 Nov 24; 9(11):10931-40. PMID: 26493711.
      View in: PubMed
    12. Matsumoto NM, Buchman GW, Rome LH, Maynard HD. Dual pH- and Temperature-Responsive Protein Nanoparticles. Eur Polym J. 2015 Aug 01; 69:532-539. PMID: 26365998.
      View in: PubMed
    13. Zhu Y, Jiang J, Said-Sadier N, Boxx G, Champion C, Tetlow A, Kickhoefer VA, Rome LH, Ojcius DM, Kelly KA. Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope. Vaccine. 2015 Jan 03; 33(2):298-306. PMID: 25448112.
      View in: PubMed
    14. Mrazek J, Toso D, Ryazantsev S, Zhang X, Zhou ZH, Fernandez BC, Kickhoefer VA, Rome LH. Polyribosomes are molecular 3D nanoprinters that orchestrate the assembly of vault particles. ACS Nano. 2014 Nov 25; 8(11):11552-9. PMID: 25354757.
      View in: PubMed
    15. Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS Nano. 2014 Aug 26; 8(8):7723-32. PMID: 25061969.
      View in: PubMed
    16. Matsumoto NM, Prabhakaran P, Rome LH, Maynard HD. Smart vaults: thermally-responsive protein nanocapsules. ACS Nano. 2013 Jan 22; 7(1):867-74. PMID: 23259767.
      View in: PubMed
    17. Yang J, Srinivasan A, Sun Y, Mrazek J, Shu Z, Kickhoefer VA, Rome LH. Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake. Integr Biol (Camb). 2013 Jan; 5(1):151-8. PMID: 22785558.
      View in: PubMed
    18. Sharma S, Zhu L, Srivastava MK, Harris-White M, Huang M, Lee JM, Rosen F, Lee G, Wang G, Kickhoefer V, Rome LH, Baratelli F, St John M, Reckamp K, Chul-Yang S, Hillinger S, Strieter R, Dubinett S. CCL21 Chemokine Therapy for Lung Cancer. Int Trends Immun. 2013 Jan; 1(1):10-15. PMID: 25264541.
      View in: PubMed
    19. Rome LH, Kickhoefer VA. Development of the vault particle as a platform technology. ACS Nano. 2013 Feb 26; 7(2):889-902. PMID: 23267674.
      View in: PubMed
    20. Kar UK, Jiang J, Champion CI, Salehi S, Srivastava M, Sharma S, Rabizadeh S, Niazi K, Kickhoefer V, Rome LH, Kelly KA. Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice. PLoS One. 2012; 7(7):e38553. PMID: 22808011.
      View in: PubMed
    21. Han M, Kickhoefer VA, Nemerow GR, Rome LH. Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm. ACS Nano. 2011 Aug 23; 5(8):6128-37. PMID: 21740042.
      View in: PubMed
    22. Kar UK, Srivastava MK, Andersson A, Baratelli F, Huang M, Kickhoefer VA, Dubinett SM, Rome LH, Sharma S. Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth. PLoS One. 2011 May 03; 6(5):e18758. PMID: 21559281.
      View in: PubMed
    23. Buehler DC, Toso DB, Kickhoefer VA, Zhou ZH, Rome LH. Vaults engineered for hydrophobic drug delivery. Small. 2011 May 23; 7(10):1432-9. PMID: 21506266.
      View in: PubMed
    24. Yang J, Kickhoefer VA, Ng BC, Gopal A, Bentolila LA, John S, Tolbert SH, Rome LH. Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange. ACS Nano. 2010 Dec 28; 4(12):7229-40. PMID: 21121616.
      View in: PubMed
    25. Xia Y, Ramgopal Y, Li H, Shang L, Srinivas P, Kickhoefer VA, Rome LH, Preiser PR, Boey F, Zhang H, Venkatraman SS. Immobilization of recombinant vault nanoparticles on solid substrates. ACS Nano. 2010 Mar 23; 4(3):1417-24. PMID: 20146454.
      View in: PubMed
    26. Goldsmith LE, Pupols M, Kickhoefer VA, Rome LH, Monbouquette HG. Utilization of a protein "shuttle" to load vault nanocapsules with gold probes and proteins. ACS Nano. 2009 Oct 27; 3(10):3175-83. PMID: 19775119.
      View in: PubMed
    27. Champion CI, Kickhoefer VA, Liu G, Moniz RJ, Freed AS, Bergmann LL, Vaccari D, Raval-Fernandes S, Chan AM, Rome LH, Kelly KA. A vault nanoparticle vaccine induces protective mucosal immunity. PLoS One. 2009; 4(4):e5409. PMID: 19404403.
      View in: PubMed
    28. Esfandiary R, Kickhoefer VA, Rome LH, Joshi SB, Middaugh CR. Structural stability of vault particles. J Pharm Sci. 2009 Apr; 98(4):1376-86. PMID: 18683860.
      View in: PubMed
    29. Lai CY, Wiethoff CM, Kickhoefer VA, Rome LH, Nemerow GR. Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer. ACS Nano. 2009 Mar 24; 3(3):691-9. PMID: 19226129.
      View in: PubMed
    30. Kickhoefer VA, Han M, Raval-Fernandes S, Poderycki MJ, Moniz RJ, Vaccari D, Silvestry M, Stewart PL, Kelly KA, Rome LH. Targeting vault nanoparticles to specific cell surface receptors. ACS Nano. 2009 Jan 27; 3(1):27-36. PMID: 19206245.
      View in: PubMed
    31. Ng BC, Yu M, Gopal A, Rome LH, Monbouquette HG, Tolbert SH. Encapsulation of semiconducting polymers in vault protein cages. Nano Lett. 2008 Oct; 8(10):3503-9. PMID: 18803422.
      View in: PubMed
    32. Yu M, Ng BC, Rome LH, Tolbert SH, Monbouquette HG. Reversible pH lability of cross-linked vault nanocapsules. Nano Lett. 2008 Oct; 8(10):3510-5. PMID: 18803423.
      View in: PubMed
    33. Anderson DH, Kickhoefer VA, Sievers SA, Rome LH, Eisenberg D. Draft crystal structure of the vault shell at 9-A resolution. PLoS Biol. 2007 Nov; 5(11):e318. PMID: 18044992.
      View in: PubMed
    34. Kaddis CS, Lomeli SH, Yin S, Berhane B, Apostol MI, Kickhoefer VA, Rome LH, Loo JA. Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility. J Am Soc Mass Spectrom. 2007 Jul; 18(7):1206-16. PMID: 17434746.
      View in: PubMed
    35. Goldsmith LE, Yu M, Rome LH, Monbouquette HG. Vault nanocapsule dissociation into halves triggered at low pH. Biochemistry. 2007 Mar 13; 46(10):2865-75. PMID: 17302392.
      View in: PubMed
    36. Poderycki MJ, Kickhoefer VA, Kaddis CS, Raval-Fernandes S, Johansson E, Zink JI, Loo JA, Rome LH. The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior. Biochemistry. 2006 Oct 03; 45(39):12184-93. PMID: 17002318.
      View in: PubMed
    37. Raval-Fernandes S, Kickhoefer VA, Kitchen C, Rome LH. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Cancer Res. 2005 Oct 01; 65(19):8846-52. PMID: 16204055.
      View in: PubMed
    38. Kickhoefer VA, Garcia Y, Mikyas Y, Johansson E, Zhou JC, Raval-Fernandes S, Minoofar P, Zink JI, Dunn B, Stewart PL, Rome LH. Engineering of vault nanocapsules with enzymatic and fluorescent properties. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4348-52. PMID: 15753293.
      View in: PubMed
    39. Poderycki MJ, Rome LH, Harrington L, Kickhoefer VA. The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Res. 2005; 33(3):893-902. PMID: 15701761.
      View in: PubMed
    40. Mikyas Y, Makabi M, Raval-Fernandes S, Harrington L, Kickhoefer VA, Rome LH, Stewart PL. Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP. J Mol Biol. 2004 Nov 12; 344(1):91-105. PMID: 15504404.
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    41. Liu Y, Snow BE, Kickhoefer VA, Erdmann N, Zhou W, Wakeham A, Gomez M, Rome LH, Harrington L. Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol. 2004 Jun; 24(12):5314-23. PMID: 15169895.
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    42. Emre N, Raval-Fernandes S, Kickhoefer VA, Rome LH. Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP. Biochim Biophys Acta. 2004 Apr 16; 1678(1):33-46. PMID: 15093136.
      View in: PubMed
    43. Kickhoefer VA, Emre N, Stephen AG, Poderycki MJ, Rome LH. Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene. Gene. 2003 May 08; 309(2):65-70. PMID: 12758122.
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    44. Kickhoefer VA, Poderycki MJ, Chan EK, Rome LH. The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein. J Biol Chem. 2002 Oct 25; 277(43):41282-6. PMID: 12196535.
      View in: PubMed
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