Leonard H Rome
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Title(s) | Professor, Biological Chemistry |
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School | Medicine |
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Address | 760 Westwood Plaza 337 Los Angeles CA 90024
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Phone | 50789 |
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vCard | Download vCard |
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Research Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
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Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones. Proc Natl Acad Sci U S A. 2021 Mar 23; 118(12).
Rayo J, Gregor R, Jacob NT, Dandela R, Dubinsky L, Yashkin A, Aranovich A, Thangaraj M, Ernst O, Barash E, Malitsky S, Florea BI, Krom BP, Wiemer EAC, Kickhoefer VA, Rome LH, Mathison JC, Kaufmann GF, Overkleeft HS, Cravatt BF, Zor T, Janda KD, Ulevitch RJ, Kravchenko VV, Meijler MM. PMID: 33723037.
View in: PubMed Mentions: Fields:
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Bioengineered recombinant vault nanoparticles coupled with NY-ESO-1 glioma-associated antigens induce maturation of native dendritic cells. J Neurooncol. 2020 May; 148(1):1-7.
Nagasawa DT, Yang J, Romiyo P, Lagman C, Chung LK, Voth BL, Duong C, Kickhoefer VA, Rome LH, Yang I. PMID: 32383063.
View in: PubMed Mentions: Fields:
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Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma. J Neurooncol. 2020 May; 147(3):599-605.
Voth BL, Pelargos PE, Barnette NE, Bhatt NS, Chen CHJ, Lagman C, Chung LK, Nguyen T, Sheppard JP, Romiyo P, Mareninov S, Kickhoefer VA, Yong WH, Rome LH, Yang I. PMID: 32274629.
View in: PubMed Mentions: Fields:
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Vault packaged enzyme mediated degradation of amino-aromatic energetic compounds. Chemosphere. 2020 Mar; 242:125117.
Lothe AG, Kalra SS, Wang M, Mack EE, Walecka-Hutchison C, Kickhoefer VA, Rome LH, Mahendra S. PMID: 31655399.
View in: PubMed Mentions: Fields: Translation: AnimalsPHPublic Health
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Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. Bioconjug Chem. 2019 08 21; 30(8):2216-2227.
Fulcher JA, Tamshen K, Wollenberg AL, Kickhoefer VA, Mrazek J, Elliott J, Ibarrondo FJ, Anton PA, Rome LH, Maynard HD, Deming T, Yang OO. PMID: 31265254.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Synthesis and assembly of human vault particles in yeast. Biotechnol Bioeng. 2018 12; 115(12):2941-2950.
Wang M, Kickhoefer VA, Rome LH, Foellmer OK, Mahendra S. PMID: 30171681.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Solution Structures of Engineered Vault Particles. Structure. 2018 04 03; 26(4):619-626.e3.
Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH. PMID: 29551289.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Encapsulation of Exogenous Proteins in Vault Nanoparticles. Methods Mol Biol. 2018; 1798:25-37.
Wang M, Abad D, Kickhoefer VA, Rome LH, Mahendra S. PMID: 29868949.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Modulation of the Vault Protein-Protein Interaction for Tuning of Molecular Release. Sci Rep. 2017 11 01; 7(1):14816.
Yu K, Yau YH, Sinha A, Tan T, Kickhoefer VA, Rome LH, Lee H, Shochat SG, Lim S. PMID: 29093465.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant. Vaccines (Basel). 2017 Jan 19; 5(1).
Jiang J, Liu G, Kickhoefer VA, Rome LH, Li LX, McSorley SJ, Kelly KA. PMID: 28106821.
View in: PubMed Mentions:
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Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery. ACS Nano. 2017 01 24; 11(1):872-881.
Benner NL, Zang X, Buehler DC, Kickhoefer VA, Rome ME, Rome LH, Wender PA. PMID: 28029784.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Vault Nanoparticles Packaged with Enzymes as an Efficient Pollutant Biodegradation Technology. ACS Nano. 2015 Nov 24; 9(11):10931-40.
Wang M, Abad D, Kickhoefer VA, Rome LH, Mahendra S. PMID: 26493711.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCellsPHPublic Health
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Dual pH- and Temperature-Responsive Protein Nanoparticles. Eur Polym J. 2015 Aug 01; 69:532-539.
Matsumoto NM, Buchman GW, Rome LH, Maynard HD. PMID: 26365998.
View in: PubMed Mentions:
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Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope. Vaccine. 2015 Jan 03; 33(2):298-306.
Zhu Y, Jiang J, Said-Sadier N, Boxx G, Champion C, Tetlow A, Kickhoefer VA, Rome LH, Ojcius DM, Kelly KA. PMID: 25448112.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Polyribosomes are molecular 3D nanoprinters that orchestrate the assembly of vault particles. ACS Nano. 2014 Nov 25; 8(11):11552-9.
Mrazek J, Toso D, Ryazantsev S, Zhang X, Zhou ZH, Fernandez BC, Kickhoefer VA, Rome LH. PMID: 25354757.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS Nano. 2014 Aug 26; 8(8):7723-32.
Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. PMID: 25061969.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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Smart vaults: thermally-responsive protein nanocapsules. ACS Nano. 2013 Jan 22; 7(1):867-74.
Matsumoto NM, Prabhakaran P, Rome LH, Maynard HD. PMID: 23259767.
View in: PubMed Mentions: 12 Fields: Translation: Cells
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Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake. Integr Biol (Camb). 2013 Jan; 5(1):151-8.
Yang J, Srinivasan A, Sun Y, Mrazek J, Shu Z, Kickhoefer VA, Rome LH. PMID: 22785558.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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CCL21 Chemokine Therapy for Lung Cancer. Int Trends Immun. 2013 Jan; 1(1):10-15.
Sharma S, Zhu L, Srivastava MK, Harris-White M, Huang M, Lee JM, Rosen F, Lee G, Wang G, Kickhoefer V, Rome LH, Baratelli F, St John M, Reckamp K, Chul-Yang S, Hillinger S, Strieter R, Dubinett S. PMID: 25264541.
View in: PubMed Mentions:
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Development of the vault particle as a platform technology. ACS Nano. 2013 Feb 26; 7(2):889-902.
Rome LH, Kickhoefer VA. PMID: 23267674.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice. PLoS One. 2012; 7(7):e38553.
Kar UK, Jiang J, Champion CI, Salehi S, Srivastava M, Sharma S, Rabizadeh S, Niazi K, Kickhoefer V, Rome LH, Kelly KA. PMID: 22808011.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCellsPHPublic Health
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Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm. ACS Nano. 2011 Aug 23; 5(8):6128-37.
Han M, Kickhoefer VA, Nemerow GR, Rome LH. PMID: 21740042.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth. PLoS One. 2011 May 03; 6(5):e18758.
Kar UK, Srivastava MK, Andersson A, Baratelli F, Huang M, Kickhoefer VA, Dubinett SM, Rome LH, Sharma S. PMID: 21559281.
View in: PubMed Mentions: 35 Fields: Translation: HumansAnimalsCells
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Vaults engineered for hydrophobic drug delivery. Small. 2011 May 23; 7(10):1432-9.
Buehler DC, Toso DB, Kickhoefer VA, Zhou ZH, Rome LH. PMID: 21506266.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange. ACS Nano. 2010 Dec 28; 4(12):7229-40.
Yang J, Kickhoefer VA, Ng BC, Gopal A, Bentolila LA, John S, Tolbert SH, Rome LH. PMID: 21121616.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Immobilization of recombinant vault nanoparticles on solid substrates. ACS Nano. 2010 Mar 23; 4(3):1417-24.
Xia Y, Ramgopal Y, Li H, Shang L, Srinivas P, Kickhoefer VA, Rome LH, Preiser PR, Boey F, Zhang H, Venkatraman SS. PMID: 20146454.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Utilization of a protein "shuttle" to load vault nanocapsules with gold probes and proteins. ACS Nano. 2009 Oct 27; 3(10):3175-83.
Goldsmith LE, Pupols M, Kickhoefer VA, Rome LH, Monbouquette HG. PMID: 19775119.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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A vault nanoparticle vaccine induces protective mucosal immunity. PLoS One. 2009; 4(4):e5409.
Champion CI, Kickhoefer VA, Liu G, Moniz RJ, Freed AS, Bergmann LL, Vaccari D, Raval-Fernandes S, Chan AM, Rome LH, Kelly KA. PMID: 19404403.
View in: PubMed Mentions: 36 Fields: Translation: AnimalsCells
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Structural stability of vault particles. J Pharm Sci. 2009 Apr; 98(4):1376-86.
Esfandiary R, Kickhoefer VA, Rome LH, Joshi SB, Middaugh CR. PMID: 18683860.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer. ACS Nano. 2009 Mar 24; 3(3):691-9.
Lai CY, Wiethoff CM, Kickhoefer VA, Rome LH, Nemerow GR. PMID: 19226129.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Targeting vault nanoparticles to specific cell surface receptors. ACS Nano. 2009 Jan 27; 3(1):27-36.
Kickhoefer VA, Han M, Raval-Fernandes S, Poderycki MJ, Moniz RJ, Vaccari D, Silvestry M, Stewart PL, Kelly KA, Rome LH. PMID: 19206245.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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Encapsulation of semiconducting polymers in vault protein cages. Nano Lett. 2008 Oct; 8(10):3503-9.
Ng BC, Yu M, Gopal A, Rome LH, Monbouquette HG, Tolbert SH. PMID: 18803422.
View in: PubMed Mentions:
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Reversible pH lability of cross-linked vault nanocapsules. . 2008 Oct; 8(10):3510-5.
Yu M, Ng BC, Rome LH, Tolbert SH, Monbouquette HG. PMID: 18803423.
View in: PubMed Mentions:
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Draft crystal structure of the vault shell at 9-A resolution. PLoS Biol. 2007 Nov; 5(11):e318.
Anderson DH, Kickhoefer VA, Sievers SA, Rome LH, Eisenberg D. PMID: 18044992.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility. J Am Soc Mass Spectrom. 2007 Jul; 18(7):1206-16.
Kaddis CS, Lomeli SH, Yin S, Berhane B, Apostol MI, Kickhoefer VA, Rome LH, Loo JA. PMID: 17434746.
View in: PubMed Mentions: 52 Fields: Translation: Cells
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Vault nanocapsule dissociation into halves triggered at low pH. Biochemistry. 2007 Mar 13; 46(10):2865-75.
Goldsmith LE, Yu M, Rome LH, Monbouquette HG. PMID: 17302392.
View in: PubMed Mentions: 16 Fields: Translation: Cells
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The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior. Biochemistry. 2006 Oct 03; 45(39):12184-93.
Poderycki MJ, Kickhoefer VA, Kaddis CS, Raval-Fernandes S, Johansson E, Zink JI, Loo JA, Rome LH. PMID: 17002318.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Cancer Res. 2005 Oct 01; 65(19):8846-52.
Raval-Fernandes S, Kickhoefer VA, Kitchen C, Rome LH. PMID: 16204055.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Engineering of vault nanocapsules with enzymatic and fluorescent properties. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4348-52.
Kickhoefer VA, Garcia Y, Mikyas Y, Johansson E, Zhou JC, Raval-Fernandes S, Minoofar P, Zink JI, Dunn B, Stewart PL, Rome LH. PMID: 15753293.
View in: PubMed Mentions: 37 Fields: Translation: HumansCells
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The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Res. 2005; 33(3):893-902.
Poderycki MJ, Rome LH, Harrington L, Kickhoefer VA. PMID: 15701761.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP. J Mol Biol. 2004 Nov 12; 344(1):91-105.
Mikyas Y, Makabi M, Raval-Fernandes S, Harrington L, Kickhoefer VA, Rome LH, Stewart PL. PMID: 15504404.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol. 2004 Jun; 24(12):5314-23.
Liu Y, Snow BE, Kickhoefer VA, Erdmann N, Zhou W, Wakeham A, Gomez M, Rome LH, Harrington L. PMID: 15169895.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP. Biochim Biophys Acta. 2004 Apr 16; 1678(1):33-46.
Emre N, Raval-Fernandes S, Kickhoefer VA, Rome LH. PMID: 15093136.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene. Gene. 2003 May 08; 309(2):65-70.
Kickhoefer VA, Emre N, Stephen AG, Poderycki MJ, Rome LH. PMID: 12758122.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein. J Biol Chem. 2002 Oct 25; 277(43):41282-6.
Kickhoefer VA, Poderycki MJ, Chan EK, Rome LH. PMID: 12196535.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2002 | 1 | 2003 | 1 | 2004 | 3 | 2005 | 3 | 2006 | 1 | 2007 | 3 | 2008 | 2 | 2009 | 5 | 2010 | 2 | 2011 | 3 | 2012 | 2 | 2013 | 3 | 2014 | 3 | 2015 | 2 | 2017 | 3 | 2018 | 3 | 2019 | 2 | 2020 | 2 | 2021 | 1 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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