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Linda G Baum

Title(s)Professor, Pathology and Laboratory Medicine
SchoolMedicine
Address760 Westwood Plaza A3-251
Los Angeles CA 90024
Phone65985
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of inflammatory cell migration in asthma
    NIH/NHLBI R21HL102989May 1, 2010 - Apr 30, 2012
    Role: Principal Investigator
    Overcoming tumor cell resistance to apoptosis with a natural product, GCS-100
    NIH/NCI R21CA139368May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Nipah Virus Pathobiology and Effects on Innate Immunity
    NIH/NIAID R01AI060694Mar 15, 2005 - Feb 28, 2010
    Role: Principal Investigator
    A Novel Cell Death Pathway Induced by Galectin-1
    NIH/NIGMS R01GM063281Sep 1, 1997 - May 31, 2005
    Role: Principal Investigator
    GALECTIN-1 INDUCES CELLULAR APOPTOSIS
    NIH/NIAID R01AI040118Sep 1, 1997 - Aug 31, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lectin-binding characterizes the healthy human skeletal muscle glycophenotype and identifies disease-specific changes in dystrophic muscle. Glycobiology. 2017 12 01; 27(12):1134-1143. McMorran BJ, Miceli MC, Baum LG. PMID: 28973355.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Galectin-9 binds to O-glycans on protein disulfide isomerase. Glycobiology. 2017 09 01; 27(9):878-887. Schaefer K, Webb NE, Pang M, Hernandez-Davies JE, Lee KP, Gonzalez P, Douglass MV, Lee B, Baum LG. PMID: 28810662.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. The direct and indirect effects of glycans on immune function. Glycobiology. 2017 07 01; 27(7):619-624. Baum LG, Cobb BA. PMID: 28460052.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. Why we love glycobiology. Glycobiology. 2016 06; 26(6):543. Baum LG, Haltiwanger RS. PMID: 27122386.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx. Glycobiology. 2016 10; 26(10):1120-1132. McMorran BJ, McCarthy FE, Gibbs EM, Pang M, Marshall JL, Nairn AV, Moremen KW, Crosbie-Watson RH, Baum LG. PMID: 27236198.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Galectins and Immune Responses-Just How Do They Do Those Things They Do? Annu Rev Immunol. 2016 05 20; 34:243-64. Thiemann S, Baum LG. PMID: 26907217.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    7. Sweet beginning for cancer stem cells. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):815-6. Baum LG. PMID: 26772316.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Galectin-1 regulates tissue exit of specific dendritic cell populations. J Biol Chem. 2015 Sep 11; 290(37):22662-77. Thiemann S, Man JH, Chang MH, Lee B, Baum LG. PMID: 26216879.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Assessing the roles of galectins in regulating dendritic cell migration through extracellular matrix and across lymphatic endothelial cells. Methods Mol Biol. 2015; 1207:215-29. Thiemann S, Man JH, Baum LG. PMID: 25253143.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells. J Virol. 2015 Mar; 89(5):2520-9. Garner OB, Yun T, Pernet O, Aguilar HC, Park A, Bowden TA, Freiberg AN, Lee B, Baum LG. PMID: 25505064.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    11. Microbe-Host Interactions are Positively and Negatively Regulated by Galectin-Glycan Interactions. Front Immunol. 2014; 5:284. Baum LG, Garner OB, Schaefer K, Lee B. PMID: 24995007.
      View in: PubMed   Mentions: 22     Fields:    
    12. Introduction to special issue: Sugars, bugs and us. Glycobiology. 2013 Sep; 23(9):1025. Baum LG, Braun J. PMID: 23752713.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. FEBS J. 2013 Sep; 280(17):4210-29. Marshall JL, Kwok Y, McMorran BJ, Baum LG, Crosbie-Watson RH. PMID: 23601082.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death. Blood. 2012 Nov 29; 120(23):4635-44. Clark MC, Pang M, Hsu DK, Liu FT, de Vos S, Gascoyne RD, Said J, Baum LG. PMID: 23065155.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    15. High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding. J Biol Chem. 2012 Jun 29; 287(27):22759-70. Cabrera PV, Pang M, Marshall JL, Kung R, Nelson SF, Stalnaker SH, Wells L, Crosbie-Watson RH, Baum LG. PMID: 22570487.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival. Ann N Y Acad Sci. 2012 Apr; 1253:58-67. Clark MC, Baum LG. PMID: 22288421.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    17. Burn control, an adipocyte-specific function for galectin-12. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18575-6. Baum LG. PMID: 22058227.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Structural aspects of binding of a-linked digalactosides to human galectin-1. Glycobiology. 2011 Dec; 21(12):1627-41. Miller MC, Ribeiro JP, Roldós V, Martín-Santamaría S, Cañada FJ, Nesmelova IA, André S, Pang M, Klyosov AA, Baum LG, Jiménez-Barbero J, Gabius HJ, Mayo KH. PMID: 21712397.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    19. Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10650-5. Bi S, Hong PW, Lee B, Baum LG. PMID: 21670307.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    20. Galectin multimerization and lattice formation are regulated by linker region structure. Glycobiology. 2011 Jan; 21(1):6-12. Earl LA, Bi S, Baum LG. PMID: 20864568.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    21. The road less traveled: regulation of leukocyte migration across vascular and lymphatic endothelium by galectins. J Clin Immunol. 2011 Feb; 31(1):2-9. Thiemann S, Baum LG. PMID: 20859666.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation. PLoS Pathog. 2010 Jul 15; 6(7):e1000993. Garner OB, Aguilar HC, Fulcher JA, Levroney EL, Harrison R, Wright L, Robinson LR, Aspericueta V, Panico M, Haslam SM, Morris HR, Dell A, Lee B, Baum LG. PMID: 20657665.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    23. N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death. J Biol Chem. 2010 Jan 22; 285(4):2232-44. Earl LA, Bi S, Baum LG. PMID: 19920154.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    24. Sialic acids in T cell development and function. Biochim Biophys Acta. 2009 Dec; 1790(12):1599-610. Bi S, Baum LG. PMID: 19664692.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    25. Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling. J Biol Chem. 2009 Sep 25; 284(39):26860-70. Fulcher JA, Chang MH, Wang S, Almazan T, Hashimi ST, Eriksson AU, Wen X, Pang M, Baum LG, Singh RR, Lee B. PMID: 19635795.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. Glycoimmunology: ignore at your peril! Immunol Rev. 2009 Jul; 230(1):5-8. Baum LG, Crocker PR. PMID: 19594625.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells. J Immunol. 2009 Jun 01; 182(11):7001-8. Pang M, He J, Johnson P, Baum LG. PMID: 19454697.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans. 2008 Dec; 36(Pt 6):1472-7. Garner OB, Baum LG. PMID: 19021578.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    29. Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology. 2008 Oct; 18(10):747-9. Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. PMID: 18621991.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis. Cell Microbiol. 2008 Oct; 10(10):2078-90. Okumura CY, Baum LG, Johnson PJ. PMID: 18637021.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    31. Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes. Blood. 2008 Jul 01; 112(1):120-30. Liu SD, Whiting CC, Tomassian T, Pang M, Bissel SJ, Baum LG, Mossine VV, Poirier F, Huflejt ME, Miceli MC. PMID: 18323414.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    32. Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways. J Biol Chem. 2008 May 02; 283(18):12248-58. Bi S, Earl LA, Jacobs L, Baum LG. PMID: 18258591.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    33. Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes. Chem Biol. 2007 Oct; 14(10):1140-51. Belitsky JM, Nelson A, Hernandez JD, Baum LG, Stoddart JF. PMID: 17961826.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. T-cell activation results in microheterogeneous changes in glycosylation of CD45. Int Immunol. 2007 Jul; 19(7):847-56. Hernandez JD, Klein J, Van Dyken SJ, Marth JD, Baum LG. PMID: 17606981.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1. Cancer Res. 2007 Jul 01; 67(13):6155-62. Valenzuela HF, Pace KE, Cabrera PV, White R, Porvari K, Kaija H, Vihko P, Baum LG. PMID: 17616672.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    36. The emerging field of glycoimmunology: highlights from the Society for Glycobiology meeting, 2006. Expert Rev Clin Immunol. 2007 Jan; 3(1):7-9. Cabrera PV, Baum LG. PMID: 20476945.
      View in: PubMed   Mentions:    Fields:    
    37. Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. J Immunol. 2006 Oct 15; 177(8):5328-36. Hernandez JD, Nguyen JT, He J, Wang W, Ardman B, Green JM, Fukuda M, Baum LG. PMID: 17015718.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    38. Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans. J Immunol. 2006 Oct 01; 177(7):4718-26. Kohatsu L, Hsu DK, Jegalian AG, Liu FT, Baum LG. PMID: 16982911.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    39. Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix. J Immunol. 2006 Jul 01; 177(1):216-26. Fulcher JA, Hashimi ST, Levroney EL, Pang M, Gurney KB, Baum LG, Lee B. PMID: 16785517.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    40. Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death. Blood. 2006 Oct 01; 108(7):2399-406. Cabrera PV, Amano M, Mitoma J, Chan J, Said J, Fukuda M, Baum LG. PMID: 16778138.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    41. Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration. Lab Invest. 2006 Jun; 86(6):578-90. He J, Baum LG. PMID: 16607379.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    42. N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry. J Virol. 2006 May; 80(10):4878-89. Aguilar HC, Matreyek KA, Filone CM, Hashimi ST, Levroney EL, Negrete OA, Bertolotti-Ciarlet A, Choi DY, McHardy I, Fulcher JA, Su SV, Wolf MC, Kohatsu L, Baum LG, Lee B. PMID: 16641279.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    43. Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol. 2006 Jan 15; 176(2):778-89. Stillman BN, Hsu DK, Pang M, Brewer CF, Johnson P, Liu FT, Baum LG. PMID: 16393961.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    44. Galectin interactions with extracellular matrix and effects on cellular function. Methods Enzymol. 2006; 417:247-56. He J, Baum LG. PMID: 17132509.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    45. Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines. J Immunol. 2005 Jul 01; 175(1):413-20. Levroney EL, Aguilar HC, Fulcher JA, Kohatsu L, Pace KE, Pang M, Gurney KB, Baum LG, Lee B. PMID: 15972675.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    46. New roles for galectins in brain tumors--from prognostic markers to therapeutic targets. Brain Pathol. 2005 Apr; 15(2):124-32. Stillman BN, Mischel PS, Baum LG. PMID: 15912884.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    47. A self-assembled multivalent pseudopolyrotaxane for binding galectin-1. J Am Chem Soc. 2004 Sep 29; 126(38):11914-22. Nelson A, Belitsky JM, Vidal S, Joiner CS, Baum LG, Stoddart JF. PMID: 15382926.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    48. An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas. Am J Pathol. 2004 Mar; 164(3):893-902. Hoyer KK, Pang M, Gui D, Shintaku IP, Kuwabara I, Liu FT, Said JW, Baum LG, Teitell MA. PMID: 14982843.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    49. Amelioration of graft versus host disease by galectin-1. Clin Immunol. 2003 Dec; 109(3):295-307. Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, Hoffmann D, Emmanouilides CE, Territo MC, Baldwin GC. PMID: 14697744.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    50. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004 Feb 06; 279(6):4705-12. He J, Baum LG. PMID: 14617626.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    51. Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death. Glycobiology. 2003 Dec; 13(12):909-18. Lantéri M, Giordanengo V, Hiraoka N, Fuzibet JG, Auberger P, Fukuda M, Baum LG, Lefebvre JC. PMID: 12925577.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    52. Galectin-1-mediated apoptosis in mycosis fungoides: the roles of CD7 and cell surface glycosylation. Mod Pathol. 2003 Jun; 16(6):543-51. Roberts AA, Amano M, Felten C, Galvan M, Sulur G, Pinter-Brown L, Dobbeling U, Burg G, Said J, Baum LG. PMID: 12808059.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    53. Preparation of recombinant human galectin-1 and use in T-cell death assays. Methods Enzymol. 2003; 363:499-518. Pace KE, Hahn HP, Baum LG. PMID: 14579599.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    54. The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem. 2003 Feb 28; 278(9):7469-75. Amano M, Galvan M, He J, Baum LG. PMID: 12499376.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    55. Ah, sweet mystery of death! Galectins and control of cell fate. Glycobiology. 2002 Oct; 12(10):127R-36R. Hernandez JD, Baum LG. PMID: 12244068.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    56. Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions. Curr Opin Struct Biol. 2002 Oct; 12(5):616-23. Brewer CF, Miceli MC, Baum LG. PMID: 12464313.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    57. Characterization of a novel Drosophila melanogaster galectin. Expression in developing immune, neural, and muscle tissues. J Biol Chem. 2002 Apr 12; 277(15):13091-8. Pace KE, Lebestky T, Hummel T, Arnoux P, Kwan K, Baum LG. PMID: 11809773.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    58. Developing a taste for sweets. Immunity. 2002 Jan; 16(1):5-8. Baum LG. PMID: 11825561.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    59. Insect galectins: roles in immunity and development. Glycoconj J. 2002; 19(7-9):607-14. Pace KE, Baum LG. PMID: 14758086.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
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