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Gordon, Lynn Kathryn

Title(s)Professor-in-Residence, Ophthalmology
Phone42095
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    PD-ligand, a Paradoxical Role in Experimental Uveitis Pathogenesis and Therapy
    NIH/NEI R21EY025389Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Novel Therapies to Prevent Blindness Caused by Proliferative Vitreoretinopathy
    NIH/NEI R01EY019909Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    Emp2: Potential Control Of Pathology In Retinal Pigment Epithelium
    VA I01BX000190Oct 1, 2009 - Mar 31, 2010
    Role: Principal Investigator
    Beta-B1 Crystallin - a New Candidate Uveitis Autoantigen
    NIH/NEI R03EY013708Sep 3, 2001 - Aug 31, 2004
    Role: Principal Investigator
    IMMUNE MECHANISMS OF OCULAR INFLAMMATORY DISEASE
    NIH/NEI K08EY000360Mar 1, 1997 - Feb 28, 2002
    Role: Principal Investigator
    IMMUNE MECHANISMS OF OCULAR INFLAMMATORY DISEASE
    NIH/NEI K23EY000360Mar 1, 1997 - Feb 28, 2002
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Patel KS, Kejriwal S, Sun MM, Thammachantha S, Duong C, Chan A, Cherian N, Romiyo P, Gordon LK, Yong W, Wadehra M, Yang I. Identification of epithelial membrane protein 2 (EMP2) as a molecular marker and correlate for angiogenesis in meningioma. J Neurooncol. 2020 Jan 24. PMID: 31981014.
      View in: PubMed
    2. Gordon LK, Danesh-Meyer H. Neuro-Ophthalmic Manifestations of HIV Infection. Ocul Immunol Inflamm. 2020 Jan 21; 1-9. PMID: 31961200.
      View in: PubMed
    3. Lin F, Oh SK, Gordon LK, Pineles SL, Rosenberg JB, Tsui I. Gender-based differences in letters of recommendation written for ophthalmology residency applicants. BMC Med Educ. 2019 Dec 30; 19(1):476. PMID: 31888607.
      View in: PubMed
    4. Jagsi R, Means O, Lautenberger D, Jones RD, Griffith KA, Flotte TR, Gordon LK, Rexrode KM, Wagner LW, Chatterjee A. Women's Representation Among Members and Leaders of National Medical Specialty Societies. Acad Med. 2019 Oct 15. PMID: 31625994.
      View in: PubMed
    5. Sun MM, Gordon LK, Levinson RD. Implications of Birdshot-Like Uveitis on the Pathogenesis of Birdshot Chorioretinopathy. JAMA Ophthalmol. 2019 05 01; 137(5):583-584. PMID: 30869756.
      View in: PubMed
    6. Sun MM, Levinson RD, Filipowicz A, Anesi S, Kaplan HJ, Wang W, Goldstein DA, Gangaputra S, Swan RT, Sen HN, Gordon LK. Uveitis in Patients Treated with CTLA-4 and PD-1 Checkpoint Blockade Inhibition. Ocul Immunol Inflamm. 2020; 28(2):217-227. PMID: 30821569.
      View in: PubMed
    7. Sun MM, Chan AM, Law SM, Duarte S, Diaz-Aguilar D, Wadehra M, Gordon LK. Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):245-254. PMID: 30646013.
      View in: PubMed
    8. Bates CK, Jagsi R, Gordon LK, Travis E, Chatterjee A, Gillis M, Means O, Chaudron L, Ganetzky R, Gulati M, Fivush B, Sharma P, Grover A, Lautenberger D, Flotte TR. It Is Time for Zero Tolerance for Sexual Harassment in Academic Medicine. Acad Med. 2018 02; 93(2):163-165. PMID: 29116986.
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    9. Qin Y, Chan AM, Chang YL, Matynia A, Kouris NA, Kimbrel EA, Ashki N, Parikh S, Gorin MB, Lanza R, Levinson RD, Gordon LK. Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice. Ocul Immunol Inflamm. 2018; 26(8):1228-1236. PMID: 28914568.
      View in: PubMed
    10. Chung LK, Pelargos PE, Chan AM, Demos JV, Lagman C, Sheppard JP, Nguyen T, Chang YL, Hojat SA, Prins RM, Liau LM, Nghiemphu L, Lai A, Cloughesy TF, Yong WH, Gordon LK, Wadehra M, Yang I. Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas. Brain Tumor Pathol. 2018 Jan; 35(1):1-9. PMID: 28887715.
      View in: PubMed
    11. Chung LK, Bhatt NS, Lagman C, Pelargos PE, Qin Y, Gordon LK, Wadehra M, Yang I. Epithelial membrane protein 2: Molecular interactions and clinical implications. J Clin Neurosci. 2017 Oct; 44:84-88. PMID: 28720310.
      View in: PubMed
    12. Qin Y, Takahashi M, Sheets K, Soto H, Tsui J, Pelargos P, Antonios JP, Kasahara N, Yang I, Prins RM, Braun J, Gordon LK, Wadehra M. Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme. J Neurooncol. 2017 Aug; 134(1):29-40. PMID: 28597184.
      View in: PubMed
    13. Gordon LK. Optic Nerve. Handb Exp Pharmacol. 2017; 242:369-386. PMID: 27787712.
      View in: PubMed
    14. Subramanian PS, Gordon LK, Bonelli L, Arnold AC. Progression of asymptomatic optic disc swelling to non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2017 May; 101(5):671-675. PMID: 27565987.
      View in: PubMed
    15. Wang W, Chan A, Qin Y, Kwong JMK, Caprioli J, Levinson R, Chen L, Gordon LK. Programmed cell death-1 is expressed in large retinal ganglion cells and is upregulated after optic nerve crush. Exp Eye Res. 2015 Nov; 140:1-9. PMID: 26277582.
      View in: PubMed
    16. Smith RJ, McCannel CA, Gordon LK, Hollander DA, Giaconi JA, Stelzner SK, Devgan U, Bartlett J, Mondino BJ. Evaluating teaching methods: validation of an evaluation tool for hydrodissection and phacoemulsification portions of cataract surgery. J Cataract Refract Surg. 2014 Sep; 40(9):1506-1513.e4. PMID: 25135543.
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    17. Ashki N, Chan AM, Qin Y, Wang W, Kiyohara M, Lin L, Braun J, Wadehra M, Gordon LK. Peroxynitrite upregulates angiogenic factors VEGF-A, BFGF, and HIF-1a in human corneal limbal epithelial cells. Invest Ophthalmol Vis Sci. 2014 Mar 19; 55(3):1637-46. PMID: 24398102.
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    18. Fu M, Maresh EL, Helguera GF, Kiyohara M, Qin Y, Ashki N, Daniels-Wells TR, Aziz N, Gordon LK, Braun J, Elshimali Y, Soslow RA, Penichet ML, Goodglick L, Wadehra M. Rationale and preclinical efficacy of a novel anti-EMP2 antibody for the treatment of invasive breast cancer. Mol Cancer Ther. 2014 Apr; 13(4):902-15. PMID: 24448822.
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    19. Morales SA, Telander DG, Leon D, Forward K, Braun J, Wadehra M, Gordon LK. Epithelial membrane protein 2 controls VEGF expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2013 Mar 28; 54(3):2367-72. PMID: 23439602.
      View in: PubMed
    20. Fu M, Brewer S, Olafsen T, Wu AM, Gordon LK, Said J, Braun J, Wadehra M. Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. Mol Imaging Biol. 2013 Feb; 15(1):68-78. PMID: 22585360.
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    21. Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK. Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. J Neuroophthalmol. 2012 Sep; 32(3):227-37. PMID: 22635166.
      View in: PubMed
    22. Morales SA, Telander DG, Mareninov S, Nagy A, Wadehra M, Braun J, Gordon LK. Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells. Exp Eye Res. 2012 Sep; 102:10-6. PMID: 22728127.
      View in: PubMed
    23. Smith RJ, McCannel CA, Gordon LK, Hollander DA, Giaconi JA, Stelzner SK, Devgan U, Bartlett J, Mondino BJ. Evaluating teaching methods of cataract surgery: validation of an evaluation tool for assessing surgical technique of capsulorhexis. J Cataract Refract Surg. 2012 May; 38(5):799-806. PMID: 22520304.
      View in: PubMed
    24. Morales SA, Telander D, Notterpek L, Wadehra M, Braun J, Gordon LK. Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5465-72. PMID: 21421883.
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    25. Rao RG, Sudhakar D, Hogue CP, Amici S, Gordon LK, Braun J, Notterpek L, Goodglick L, Wadehra M. Peripheral myelin protein-22 (PMP22) modulates alpha 6 integrin expression in the human endometrium. Reprod Biol Endocrinol. 2011 Apr 25; 9:56. PMID: 21518455.
      View in: PubMed
    26. Habeeb O, Goodglick L, Soslow RA, Rao RG, Gordon LK, Schirripa O, Horvath S, Braun J, Seligson DB, Wadehra M. Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development. Cancer. 2010 Oct 15; 116(20):4718-26. PMID: 20578181.
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    27. Fu M, Maresh EL, Soslow RA, Alavi M, Mah V, Zhou Q, Iasonos A, Goodglick L, Gordon LK, Braun J, Wadehra M. Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer. Clin Cancer Res. 2010 Aug 01; 16(15):3954-63. PMID: 20670949.
      View in: PubMed
    28. Costa RM, Dumitrascu OM, Gordon LK. Orbital myositis: diagnosis and management. Curr Allergy Asthma Rep. 2009 Jul; 9(4):316-23. PMID: 19656480.
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    29. Morales SA, Mareninov S, Coulam P, Wadehra M, Goodglick L, Braun J, Gordon LK. Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2). Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4949-56. PMID: 19494199.
      View in: PubMed
    30. Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK. Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4941-8. PMID: 19420345.
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    31. Shimazaki K, Chan AM, Moniz RJ, Wadehra M, Nagy A, Coulam CP, Mareninov S, Lepin EM, Wu AM, Kelly KA, Braun J, Gordon LK. Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model. FEMS Immunol Med Microbiol. 2009 Mar; 55(2):240-9. PMID: 19159428.
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    32. Chen L, Pai V, Levinson R, Sharpe AH, Freeman GJ, Braun J, Gordon LK. Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocul Immunol Inflamm. 2009 Jan-Feb; 17(1):47-55. PMID: 19294574.
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    33. Shimazaki K, Lepin EJ, Wei B, Nagy AK, Coulam CP, Mareninov S, Fu M, Wu AM, Marks JD, Braun J, Gordon LK, Wadehra M. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Clin Cancer Res. 2008 Nov 15; 14(22):7367-77. PMID: 19010852.
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    34. Kim SH, Munemasa Y, Kwong JM, Ahn JH, Mareninov S, Gordon LK, Caprioli J, Piri N. Activation of autophagy in retinal ganglion cells. J Neurosci Res. 2008 Oct; 86(13):2943-51. PMID: 18521932.
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    35. Chen L, Holland GN, Yu F, Levinson RD, Lampi KJ, Horwitz J, Gordon LK. Associations of seroreactivity against crystallin proteins with disease activity and cataract in patients with uveitis. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4476-81. PMID: 18539933.
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    36. Morales SA, Mareninov S, Wadehra M, Zhang L, Goodglick L, Braun J, Gordon LK. FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):462-9. PMID: 18469192.
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    37. Wadehra M, Mainigi M, Morales SA, Rao RG, Gordon LK, Williams CJ, Braun J. Steroid hormone regulation of EMP2 expression and localization in the endometrium. Reprod Biol Endocrinol. 2008 Apr 09; 6:15. PMID: 18400107.
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    38. Shimazaki K, Jirawuthiworavong GV, Heckenlively JR, Gordon LK. Frequency of anti-retinal antibodies in normal human serum. J Neuroophthalmol. 2008 Mar; 28(1):5-11. PMID: 18347451.
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    39. Ramirez AM, Chaya CJ, Gordon LK, Giaconi JA. A comparison of semiautomated versus manual Goldmann kinetic perimetry in patients with visually significant glaucoma. J Glaucoma. 2008 Mar; 17(2):111-7. PMID: 18344756.
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    40. Shimazaki K, Jirawuthiworavong GV, Nguyen EV, Awazu M, Levinson RD, Gordon LK. Tubulointerstitial nephritis and uveitis syndrome: a case with an autoimmune reactivity against retinal and renal antigens. Ocul Immunol Inflamm. 2008 Jan-Feb; 16(1):51-3. PMID: 18379944.
      View in: PubMed
    41. Gordon LK, Monnet D, Holland GN, Brézin AP, Yu F, Levinson RD. Longitudinal cohort study of patients with birdshot chorioretinopathy. IV. Visual field results at baseline. Am J Ophthalmol. 2007 Dec; 144(6):829-837. PMID: 17937923.
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    42. Morales SA, Mareninov S, Prasad P, Wadehra M, Braun J, Gordon LK. Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway. Exp Eye Res. 2007 Dec; 85(6):790-8. PMID: 17915217.
      View in: PubMed
    43. Forbes A, Wadehra M, Mareninov S, Morales S, Shimazaki K, Gordon LK, Braun J. The tetraspan protein EMP2 regulates expression of caveolin-1. J Biol Chem. 2007 Sep 07; 282(36):26542-51. PMID: 17609206.
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    44. Shimazaki K, Wadehra M, Forbes A, Chan AM, Goodglick L, Kelly KA, Braun J, Gordon LK. Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn). Microbes Infect. 2007 Jul; 9(8):1003-10. PMID: 17544801.
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    45. Straatsma BR, Nusinowitz S, Young TA, Gordon LK, Chun MW, Rosen C, Seja E, Economou JS, Glaspy JA, Bozon V, Gomez-Navarro J, Ribas A. Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma. Am J Ophthalmol. 2007 Jun; 143(6):958-969. PMID: 17434437.
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    46. Gordon LK, Goldhardt R, Holland GN, Yu F, Levinson RD. Standardized visual field assessment for patients with birdshot chorioretinopathy. Ocul Immunol Inflamm. 2006 Dec; 14(6):325-32. PMID: 17162602.
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    47. Gordon LK. Orbital inflammatory disease: a diagnostic and therapeutic challenge. Eye (Lond). 2006 Oct; 20(10):1196-206. PMID: 17019419.
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    48. Kwong JM, Lalezary M, Nguyen JK, Yang C, Khattar A, Piri N, Mareninov S, Gordon LK, Caprioli J. Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells. Neurosci Lett. 2006 Sep 25; 405(3):191-5. PMID: 16889897.
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    49. Monnet D, Brézin AP, Holland GN, Yu F, Mahr A, Gordon LK, Levinson RD. Longitudinal cohort study of patients with birdshot chorioretinopathy. I. Baseline clinical characteristics. Am J Ophthalmol. 2006 Jan; 141(1):135-42. PMID: 16386987.
      View in: PubMed
    50. Shah KH, Levinson RD, Yu F, Goldhardt R, Gordon LK, Gonzales CR, Heckenlively JR, Kappel PJ, Holland GN. Birdshot chorioretinopathy. Surv Ophthalmol. 2005 Nov-Dec; 50(6):519-41. PMID: 16263368.
      View in: PubMed
    51. Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ, Braun J. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol. 2005 Nov 15; 287(2):336-45. PMID: 16216233.
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    52. Kassan H, Cohavy O, Rosenbaum JT, Braun J, Gordon LK. Uveitis seroreactivity to candidate pANCA antigens: mycobacterial HupB and histone H1(69-171). Ocul Immunol Inflamm. 2005 Apr-Jun; 13(2-3):191-8. PMID: 16019678.
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    53. Gordon LK, Ribas A, Nusinowitz S, Butterfield LH, Glaspy JA, Economou JS, Straatsma BR. Surveillance of the eye and vision in a clinical trial of MART1-transformed dendritic cells for metastatic melanoma. Control Clin Trials. 2004 Aug; 25(4):400-7. PMID: 15296814.
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    54. Wadehra M, Su H, Gordon LK, Goodglick L, Braun J. The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol. 2003 May; 107(2):129-36. PMID: 12763482.
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    55. Wadehra M, Sulur GG, Braun J, Gordon LK, Goodglick L. Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. Exp Mol Pathol. 2003 Apr; 74(2):106-12. PMID: 12710941.
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    56. Gordon LK. Diagnostic dilemmas in orbital inflammatory disease. Ocul Immunol Inflamm. 2003 Mar; 11(1):3-15. PMID: 12854023.
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    57. Stempel D, Sandusky H, Lampi K, Cilluffo M, Horwitz J, Braun J, Goodglick L, Gordon LK. BetaB1-crystallin: identification of a candidate ciliary body uveitis antigen. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):203-9. PMID: 12506076.
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