Marlin Touma

Title(s)Associate Professor-in-Residence, Pediatrics
SchoolMedicine
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    Novel Gene-Environment Regulatory Circuit in Chamber-Specific Growth of Perinatal Heart
    NIH R01HL153853Sep 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Novel Gene-Environment Regulatory Circuit in Chamber Specific Growth of Perinatal Heart
    NIH R56HL146738Sep 15, 2019 - Aug 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An ALMS1 variant disrupts proximal centriole organization and promotes a myofibroblast-like phenotype that is regulated by THY1. Res Sq. 2026 Sep 15. Zeigler A, Colijn S, Gholkar A, Yang S, Kang X, Zhao Y, Wolf C, Li S, Torres J, Nelson S, Stratman A, Touma M. PMID: 42763440; PMCID: PMC13587153.
      View in: PubMed   Mentions:
    2. Genetic drivers of congenital cardiac fibrosis. Commun Biol. 2026 05 27; 9(1). Zeigler AC, Touma M. PMID: 42203827; PMCID: PMC13216529.
      View in: PubMed   Mentions: Translation:HumansAnimals
    3. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) maintains muscle progenitor identity by stabilizing the Ppp1r1b-lncRNA-PRC2 complex. Nucleic Acids Res. 2026 May 05; 54(9). Kang X, Zhao Y, Nelson SF, Pyle A, Lusis AJ, Touma M. PMID: 42152677; PMCID: PMC13183673.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Mosaic pathogenic PRKAG2 variant and pathologic diagnosis of glycogen storage disease in an infant with negative whole-genome sequencing. JHLT Open. 2026 Aug; 13:100562. Cabido V, Huang Y, Halnon N, Fan J, Touma M, Fishbein GA, Husain M. PMID: 42100166; PMCID: PMC13146544.
      View in: PubMed   Mentions:
    5. Novel Missense Variants in TRIM37 Associated with Mulibrey Nanism and Complex Congenital Heart Disease. Cardiol Cardiovasc Med. 2026; 10(2):22-33. Zodanu GKE, Zeigler AC, Mudery J, Wolf C, Hwang JH, Kang X, Speirs A, Wang LK, Biniwale R, Si MS, Halnon N, Satou GM, UCLA Congenital Heart Defects BioCore Faculty, Grody WW, Van Arsdell GS, Nelson SF, Touma M. PMID: 41907767; PMCID: PMC13026078.
      View in: PubMed   Mentions:
    6. Endocardial Fibrosis Elastosis: Long-Standing Mystery and Promising Therapy. JACC Basic Transl Sci. 2025 Sep; 10(9):101317. Touma M. PMID: 40742361; PMCID: PMC12539427.
      View in: PubMed   Mentions:
    7. Wnt11 Positively Regulates Neonatal Cardiomyocyte Maturation at the Interphase of Life via Frizzled 4 Receptor. bioRxiv. 2025 Jun 03. Kang X, Moci J, Wolf C, Touma M. PMID: 40502145; PMCID: PMC12157699.
      View in: PubMed   Mentions:
    8. Whole-Exome Sequencing Identifies Novel GATA5/6 Variants in Right-Sided Congenital Heart Defects. Int J Mol Sci. 2025 Feb 27; 26(5). Zodanu GKE, Hwang JH, Mudery J, Sisniega C, Kang X, Wang LK, Barsegian A, Biniwale RM, Si MS, Halnon NJ, Grody WW, Satou GM, Van Arsdell GS, Nelson SF, Touma M. PMID: 40076735; PMCID: PMC11901071.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Gestational exposure to air pollutants perturbs metabolic and placenta-fetal phenotype. Reprod Toxicol. 2024 09; 128:108657. Ganguly A, Ghosh S, Shin BC, Touma M, Wadehra M, Devaskar SU. PMID: 39002939.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    10. High-Throughput Genomics Identify Novel FBN1/2 Variants in Severe Neonatal Marfan Syndrome and Congenital Heart Defects. Int J Mol Sci. 2024 May 17; 25(10). Zodanu GKE, Hwang JH, Mehta Z, Sisniega C, Barsegian A, Kang X, Biniwale R, Si MS, Satou GM, Halnon N, Grody WW, Van Arsdell GS, Nelson SF, Touma M. PMID: 38791509; PMCID: PMC11122089.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy. Circ Res. 2024 Mar 29; 134(7):913-930. Liu X, Li B, Wang S, Zhang E, Schultz M, Touma M, Monteiro Da Rocha A, Evans SM, Eichmann A, Herron T, Chen R, Xiong D, Jaworski A, Weiss S, Si MS. PMID: 38414132; PMCID: PMC10977056.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide Using Chromatin Isolation by RNA Purification (ChIRP)-seq. Cells. 2023 12 08; 12(24). Hwang J, Kang X, Wolf C, Touma M. PMID: 38132125; PMCID: PMC10741483.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide Using Chromatin Isolation by RNA Purification (ChIRP)-seq. bioRxiv. 2023 Nov 05. Hwang J, Kang X, Wolf C, Touma M. PMID: 37961291; PMCID: PMC10635152.
      View in: PubMed   Mentions:
    14. Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy. Cells. 2023 05 23; 12(11). Sono R, Larrinaga TM, Huang A, Makhlouf F, Kang X, Su J, Lau R, Arboleda VA, Biniwale R, Fishbein GA, Khanlou N, Si MS, Satou GM, Halnon N, Van Arsdell GS, Gregorio CC, Nelson S, Touma M. PMID: 37296576; PMCID: PMC10252268.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    15. Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects. Int J Mol Sci. 2023 Jan 13; 24(2). Mehta Z, Touma M. PMID: 36675070; PMCID: PMC9862068.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. A novel murine model of atrial fibrillation by diphtheria toxin-induced injury. Front Physiol. 2022; 13:977735. Trieu T, Mach P, Bunn K, Huang V, Huang J, Chow C, Nakano H, Fajardo VM, Touma M, Ren S, Wang Y, Nakano A. PMID: 36388109; PMCID: PMC9659601.
      View in: PubMed   Mentions:
    17. Case Report: Whole Exome Sequencing Identifies Compound Heterozygous Variants in TSFM Gene Causing Juvenile Hypertrophic Cardiomyopathy. Front Cardiovasc Med. 2021; 8:798985. Yang JO, Shaybekyan H, Zhao Y, Kang X, Fishbein GA, Khanlou N, Alejos JC, Halnon N, Satou G, Biniwale R, Lee H, Van Arsdell G, Nelson SF, Touma M, UCLA Clinical Genomics Center, UCLA Congenital Heart Defects-BioCore Faculty. PMID: 35071363; PMCID: PMC8770926.
      View in: PubMed   Mentions: 3  
    18. Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome. J Mol Med (Berl). 2021 11; 99(11):1623-1638. Zhao Y, Wang LK, Eskin A, Kang X, Fajardo VM, Mehta Z, Pineles S, Schmidt RJ, Nagiel A, Satou G, Garg M, Federman M, Reardon LC, Lee SL, Biniwale R, Grody WW, Halnon N, Khanlou N, Quintero-Rivera F, Alejos JC, Nakano A, Fishbein GA, Van Arsdell GS, Nelson SF, Touma M. PMID: 34387706; PMCID: PMC8541947.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart. J Clin Invest. 2020 10 01; 130(10):5287-5301. Yokota T, Li J, Huang J, Xiong Z, Zhang Q, Chan T, Ding Y, Rau C, Sung K, Ren S, Kulkarni R, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. PMID: 32573492; PMCID: PMC7524480.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. COVID-19: molecular diagnostics overview. J Mol Med (Berl). 2020 07; 98(7):947-954. Touma M. PMID: 32535768; PMCID: PMC7293435.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCellsPHPublic Health
    21. Gene-environment regulation of chamber-specific maturation during hypoxemic perinatal circulatory transition. J Mol Med (Berl). 2020 07; 98(7):1009-1020. Zhao Y, Kang X, Barsegian A, He J, Guzman A, Lau RP, Biniwale R, Wadhra M, Reemtsen B, Garg M, Halnon N, Quintero-Rivera F, Grody WW, UCLA Congenital Heart Defects BioCore Faculty, Van Arsdell G, Nelson SF, Touma M. PMID: 32533200; PMCID: PMC7843236.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020910976. Spyropoulos F, Vitali SH, Touma M, Rose CD, Petty CR, Levy P, Kourembanas S, Christou H. PMID: 32537128; PMCID: PMC7268140.
      View in: PubMed   Mentions: 19  
    23. Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human. RNA. 2020 04; 26(4):481-491. Kang X, Zhao Y, Van Arsdell G, Nelson SF, Touma M. PMID: 31953255; PMCID: PMC7075267.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    24. Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot. J Mol Med (Berl). 2019 12; 97(12):1711-1722. Zhao Y, Kang X, Gao F, Guzman A, Lau RP, Biniwale R, Wadehra M, Reemtsen B, Garg M, Halnon N, Quintero-Rivera F, Van Arsdell G, Coppola G, Nelson SF, Touma M, UCLA Congenital Heart Defects BioCore Faculty. PMID: 31834445; PMCID: PMC7942233.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System. J Vis Exp. 2018 05 05; (135). Touma M. PMID: 29781990; PMCID: PMC6101116.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Wnt11 regulates cardiac chamber development and disease during perinatal maturation. JCI Insight. 2017 09 07; 2(17). Touma M, Kang X, Gao F, Zhao Y, Cass AA, Biniwale R, Xiao X, Eghbali M, Coppola G, Reemtsen B, Wang Y. PMID: 28878122; PMCID: PMC5621892.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. A Path to Implement Precision Child Health Cardiovascular Medicine. Front Cardiovasc Med. 2017; 4:36. Touma M, Reemtsen B, Halnon N, Alejos J, Finn JP, Nelson SF, Wang Y. PMID: 28620608; PMCID: PMC5451507.
      View in: PubMed   Mentions: 9  
    28. Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery. Circ Cardiovasc Genet. 2016 Oct; 9(5):395-407. Touma M, Kang X, Zhao Y, Cass AA, Gao F, Biniwale R, Coppola G, Xiao X, Reemtsen B, Wang Y. PMID: 27591185; PMCID: PMC5085833.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    29. Maternal Calorie Restriction Causing Uteroplacental Insufficiency Differentially Affects Mammalian Placental Glucose and Leucine Transport Molecular Mechanisms. Endocrinology. 2016 Oct; 157(10):4041-4054. Ganguly A, Touma M, Thamotharan S, De Vivo DC, Devaskar SU. PMID: 27494059; PMCID: PMC5045505.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    30. Hematopoietic progenitors are required for proper development of coronary vasculature. J Mol Cell Cardiol. 2015 Sep; 86:199-207. Lluri G, Huang V, Touma M, Liu X, Harmon AW, Nakano A. PMID: 26241844; PMCID: PMC4558312.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    31. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22; 31(6):707-21. Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML. PMID: 25535917; PMCID: PMC4311887.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    32. Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system. Circ Res. 2014 Mar 28; 114(7):1103-13. Nakashima Y, Yanez DA, Touma M, Nakano H, Jaroszewicz A, Jordan MC, Pellegrini M, Roos KP, Nakano A. PMID: 24563458.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    33. Decoding the noncoding transcripts in human heart failure. Circulation. 2014 Mar 04; 129(9):958-60. Xiao XG, Touma M, Wang Y. PMID: 24429689; PMCID: PMC4046328.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    34. Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings. Epilepsia. 2013 May; 54(5):e81-5. Touma M, Joshi M, Connolly MC, Grant PE, Hansen AR, Khwaja O, Berry GT, Kinney HC, Poduri A, Agrawal PB. PMID: 23550958; PMCID: PMC3640694.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    35. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. PMID: 22287610; PMCID: PMC3362160.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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