Megan Marie McEvoy

Title(s)Professor, Institute for Society And Genetics
SchoolCollege of Letters and Science
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    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    BioMetals 2010 Conference
    NIH R13ES019369Jul 1, 2010 - Jun 30, 2011
    Role: Principal Investigator
    Mechanisms of Copper and Silver Resistance in Microbial Systems
    NIH R01GM079192Apr 1, 2007 - May 31, 2019
    Role: Principal Investigator
    MARC Biomedical Research and Training Program at the University of Arizona
    NIH T34GM008718Jun 1, 1999 - May 31, 2022
    Role: Co-Principal Investigator
    MARC U*STAR Program at the University of California, Los Angeles
    NIH T34GM008563Jun 1, 1996 - May 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Strength of Cu-efflux response in Escherichia coli coordinates metal resistance in Caenorhabditis elegans and contributes to the severity of environmental toxicity. J Biol Chem. 2021 09; 297(3):101060. Shafer CM, Tseng A, Allard P, McEvoy MM. PMID: 34375643; PMCID: PMC8424214.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Expression and Purification of Recombinant Proteins in Escherichia coli Tagged with the Metal-Binding Proteins SmbP and CusF3H. Methods Mol Biol. 2021; 2178:329-344. Gomez-Lugo JJ, Santos BD, Perez-Perez DA, Montfort-Gardeazabal JM, McEvoy MM, Zarate X. PMID: 33128759.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    3. The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster. J Biol Chem. 2020 08 07; 295(32):11364-11376. Hausrath AC, Ramirez NA, Ly AT, McEvoy MM. PMID: 32571874; PMCID: PMC7415965.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. PLoS One. 2020; 15(2):e0228877. Górecki K, McEvoy MM. PMID: 32050009; PMCID: PMC7015380.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    5. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front Microbiol. 2020; 11:68. Bazzi W, Abou Fayad AG, Nasser A, Haraoui LP, Dewachi O, Abou-Sitta G, Nguyen VK, Abara A, Karah N, Landecker H, Knapp C, McEvoy MM, Zaman MH, Higgins PG, Matar GM. PMID: 32117111; PMCID: PMC7008767.
      View in: PubMed   Mentions: 15  
    6. Mechanism of metal ion-induced activation of a two-component sensor kinase. Biochem J. 2019 01 15; 476(1):115-135. Affandi T, McEvoy MM. PMID: 30530842; PMCID: PMC6506263.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    7. Adaptor protein mediates dynamic pump assembly for bacterial metal efflux. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6694-6699. Santiago AG, Chen TY, Genova LA, Jung W, George Thompson AM, McEvoy MM, Chen P. PMID: 28607072; PMCID: PMC5495265.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    8. The Structure of the Periplasmic Sensor Domain of the Histidine Kinase CusS Shows Unusual Metal Ion Coordination at the Dimeric Interface. Biochemistry. 2016 09 20; 55(37):5296-306. Affandi T, Issaian AV, McEvoy MM. PMID: 27583660; PMCID: PMC5030187.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    9. Expression and purification of recombinant proteins in Escherichia coli tagged with the metal-binding protein CusF. Protein Expr Purif. 2016 May; 121:61-5. Cantu-Bustos JE, Vargas-Cortez T, Morones-Ramirez JR, Balderas-Renteria I, Galbraith DW, McEvoy MM, Zarate X. PMID: 26805756.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    10. Tracking metal ions through a Cu/Ag efflux pump assigns the functional roles of the periplasmic proteins. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15373-8. Chacón KN, Mealman TD, McEvoy MM, Blackburn NJ. PMID: 25313055; PMCID: PMC4217431.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    11. The histidine kinase CusS senses silver ions through direct binding by its sensor domain. Biochim Biophys Acta. 2014 Sep; 1844(9):1656-61. Gudipaty SA, McEvoy MM. PMID: 24948475; PMCID: PMC4116807.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    12. Mechanism of ATPase-mediated Cu+ export and delivery to periplasmic chaperones: the interaction of Escherichia coli CopA and CusF. J Biol Chem. 2014 Jul 25; 289(30):20492-501. Padilla-Benavides T, George Thompson AM, McEvoy MM, Argüello JM. PMID: 24917681; PMCID: PMC4110264.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    13. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle. Biosci Rep. 2012 Oct; 32(5):443-53. Jayakanthan S, Roberts SA, Weichsel A, Argüello JM, McEvoy MM. PMID: 22663904; PMCID: PMC3475447.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    14. N-terminal region of CusB is sufficient for metal binding and metal transfer with the metallochaperone CusF. Biochemistry. 2012 Aug 28; 51(34):6767-75. Mealman TD, Zhou M, Affandi T, Chacón KN, Aranguren ME, Blackburn NJ, Wysocki VH, McEvoy MM. PMID: 22812620; PMCID: PMC3448809.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    15. Regulation of Cu(I)/Ag(I) efflux genes in Escherichia coli by the sensor kinase CusS. FEMS Microbiol Lett. 2012 May; 330(1):30-7. Gudipaty SA, Larsen AS, Rensing C, McEvoy MM. PMID: 22348296; PMCID: PMC3319497.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    16. Metal export by CusCFBA, the periplasmic Cu(I)/Ag(I) transport system of Escherichia coli. Curr Top Membr. 2012; 69:163-96. Mealman TD, Blackburn NJ, McEvoy MM. PMID: 23046651.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    17. Switch or funnel: how RND-type transport systems control periplasmic metal homeostasis. J Bacteriol. 2011 May; 193(10):2381-7. Kim EH, Nies DH, McEvoy MM, Rensing C. PMID: 21398536; PMCID: PMC3133179.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    18. Biometals 2010 (Tucson, Arizona, USA). Biometals. 2011 Jun; 24(3):377-8. McEvoy MM, Rensing C. PMID: 21387113.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Interactions between CusF and CusB identified by NMR spectroscopy and chemical cross-linking coupled to mass spectrometry. Biochemistry. 2011 Apr 05; 50(13):2559-66. Mealman TD, Bagai I, Singh P, Goodlett DR, Rensing C, Zhou H, Wysocki VH, McEvoy MM. PMID: 21323389; PMCID: PMC3072847.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    20. Differing ability to transport nonmetal substrates by two RND-type metal exporters. FEMS Microbiol Lett. 2010 Jul; 308(2):115-22. Conroy O, Kim EH, McEvoy MM, Rensing C. PMID: 20497225; PMCID: PMC2917340.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    21. Chaperone-mediated copper handling in the periplasm. Nat Prod Rep. 2010 May; 27(5):711-9. Kim EH, Rensing C, McEvoy MM. PMID: 20442961.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    22. The metal efflux island of Legionella pneumophila is not required for survival in macrophages and amoebas. FEMS Microbiol Lett. 2009 Dec; 301(2):164-70. Kim EH, Charpentier X, Torres-Urquidy O, McEvoy MM, Rensing C. PMID: 19895645.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Site-directed mutagenesis identifies a molecular switch involved in copper sensing by the histidine kinase CinS in Pseudomonas putida KT2440. J Bacteriol. 2009 Aug; 191(16):5304-11. Quaranta D, McEvoy MM, Rensing C. PMID: 19542288; PMCID: PMC2725577.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    24. Tryptophan Cu(I)-pi interaction fine-tunes the metal binding properties of the bacterial metallochaperone CusF. J Biol Inorg Chem. 2009 Aug; 14(6):905-12. Loftin IR, Blackburn NJ, McEvoy MM. PMID: 19381697; PMCID: PMC2808115.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    25. Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone. Biochemistry. 2008 Nov 04; 47(44):11408-14. Bagai I, Rensing C, Blackburn NJ, McEvoy MM. PMID: 18847219; PMCID: PMC2593458.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    26. Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy. Protein Sci. 2007 Oct; 16(10):2287-93. Loftin IR, Franke S, Blackburn NJ, McEvoy MM. PMID: 17893365; PMCID: PMC2204137.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    27. Substrate-linked conformational change in the periplasmic component of a Cu(I)/Ag(I) efflux system. J Biol Chem. 2007 Dec 07; 282(49):35695-702. Bagai I, Liu W, Rensing C, Blackburn NJ, McEvoy MM. PMID: 17893146.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    28. Periplasmic metal-resistance protein CusF exhibits high affinity and specificity for both CuI and AgI. Biochemistry. 2006 Sep 19; 45(37):11096-102. Kittleson JT, Loftin IR, Hausrath AC, Engelhardt KP, Rensing C, McEvoy MM. PMID: 16964970.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    29. A novel copper-binding fold for the periplasmic copper resistance protein CusF. Biochemistry. 2005 Aug 09; 44(31):10533-40. Loftin IR, Franke S, Roberts SA, Weichsel A, Héroux A, Montfort WR, Rensing C, McEvoy MM. PMID: 16060662.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    30. Characterization of the copper(II) binding site in the pink copper binding protein CusF by electron paramagnetic resonance spectroscopy. J Biol Inorg Chem. 2005 May; 10(3):221-30. Astashkin AV, Raitsimring AM, Walker FA, Rensing C, McEvoy MM. PMID: 15770503.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    31. Structure of the constitutively active double mutant CheYD13K Y106W alone and in complex with a FliM peptide. J Mol Biol. 2004 Sep 24; 342(4):1325-35. Dyer CM, Quillin ML, Campos A, Lu J, McEvoy MM, Hausrath AC, Westbrook EM, Matsumura P, Matthews BW, Dahlquist FW. PMID: 15351654.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
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