Michael R Freeman

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Collapse Research 
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    Mechanisms of Prostate Cancer Metastasis
    NIH R01CA271750Sep 17, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Racial Differences in Prostate Cancer Molecular Subtyping
    NIH R01CA220327Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Microbiome and Proteome As Predictive Biomarkers of UCPPS
    NIH U01DK103260Sep 10, 2014 - Jun 30, 2020
    Role: Co-Principal Investigator
    Cholesterol and Prostate Health
    NIH R01DK087806Sep 16, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Amoeboid Membrane Dynamics in Prostate Cancer
    NIH R01CA143777Aug 15, 2010 - Jan 31, 2016
    Role: Principal Investigator
    Membrane Microdomains in Prostate Cancer
    NIH R01CA112303Mar 1, 2005 - Mar 31, 2011
    Role: Principal Investigator
    Children's Hospital Boston George O'Brien Urology Research Center
    NIH P50DK065298Sep 15, 2003 - Jan 31, 2014
    Role: Co-Principal Investigator
    Research Training in Pediatric Urology/CHB T32
    NIH T32DK060442Mar 1, 2002 - Jun 30, 2024
    Role: Co-Principal Investigator
    SYMPOSIUM 2000 TISSUE INTERACTIONS IN PROSTATE CANCER
    NIH R13DK058665Sep 30, 2000 - Aug 31, 2001
    Role: Principal Investigator
    CELL SIGNALING IN BLADDER HYPERTROPHY
    NIH R01DK057691Jun 1, 2000 - Apr 30, 2006
    Role: Principal Investigator
    PROSTATE CANCER-BONE INTERACTION--SECRETION OF EGFR
    NIH R01CA077386Jun 5, 1998 - Mar 31, 2004
    Role: Principal Investigator
    HEPARIN-BINDING EGF-LIKE FACTORS IN PROSTATE GROWTH
    NIH R37DK047556Aug 1, 1994 - May 30, 2010
    Role: Principal Investigator
    HEPARIN BINDING EGF LIKE FACTORS IN PROSTATE GROWTH
    NIH R01DK047556Aug 1, 1994 - Nov 30, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study. Nucleic Acids Res. 2023 02 22; 51(3):1277-1296. Luna Velez MV, Neikes HK, Snabel RR, Quint Y, Qian C, Martens A, Veenstra GJC, Freeman MR, van Heeringen SJ, Vermeulen M. PMID: 36625255; PMCID: PMC9943655.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Targeting Glutamine Metabolism in Prostate Cancer. Front Biosci (Elite Ed). 2023 Jan 04; 15(1):2. Bhowmick N, Posadas E, Ellis L, Freedland SJ, Vizio DD, Freeman MR, Theodorescu D, Figlin R, Gong J. PMID: 36959101.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Activation of ONECUT2 by RB1 loss in castration-resistant prostate cancer. Am J Clin Exp Urol. 2022; 10(6):397-407. Qian C, Yang Q, Freedland SJ, Di Vizio D, Ellis L, You S, Freeman MR. PMID: 36636695; PMCID: PMC9831918.
      View in: PubMed   Mentions:
    4. Variation in Molecularly Defined Prostate Tumor Subtypes by Self-identified Race. Eur Urol Open Sci. 2022 Jun; 40:19-26. Kensler KH, Awasthi S, Alshalalfa M, Trock BJ, Freedland SJ, Freeman MR, You S, Mahal BA, Den RB, Dicker AP, Karnes RJ, Klein EA, Lal P, Liu Y, Davicioni E, Rayford W, Yamoah K, Rebbeck TR. PMID: 35638091; PMCID: PMC9142751.
      View in: PubMed   Mentions:
    5. Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. Nat Commun. 2022 02 03; 13(1):669. Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, Lee YJ, Yuan X, Ellis L, Di Vizio D, Posadas EM, Kyprianou N, Knudsen BS, Shah K, Murali R, Gertych A, You S, Freeman MR, Yang W. PMID: 35115556; PMCID: PMC8813925.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer. Proteomics. 2022 02; 22(4):e2100172. Yan Y, Zhou B, Lee YJ, You S, Freeman MR, Yang W. PMID: 34897998; PMCID: PMC8844095.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. miR-1227 Targets SEC23A to Regulate the Shedding of Large Extracellular Vesicles. Cancers (Basel). 2021 Nov 22; 13(22). Chin A, Mariscal J, Kim M, Guerra G, Victor B, Qian C, Broseghini E, Posadas E, Freeman MR, Sharma S, Gandellini P, Zaffaroni N, You S, Chan KS, Guarnerio J, Fabbri M, Di Vizio D. PMID: 34831007; PMCID: PMC8616086.
      View in: PubMed   Mentions:
    8. Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity. Clin Cancer Res. 2022 01 15; 28(2):414-424. Wang Y, You S, Su S, Yeon A, Lo EM, Kim S, Mohler JL, Freeman MR, Kim HL. PMID: 34728526; PMCID: PMC8776603.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Clinical Utility of Olaparib in the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Review of Current Evidence and Patient Selection. Onco Targets Ther. 2021; 14:4819-4832. LeVee A, Lin CY, Posadas E, Figlin R, Bhowmick NA, Di Vizio D, Ellis L, Rosser CJ, Freeman MR, Theodorescu D, Freedland SJ, Gong J. PMID: 34552338; PMCID: PMC8450162.
      View in: PubMed   Mentions: 3  
    10. Scaffold attachment factor B1 regulates androgen degradation pathways in prostate cancer. Am J Clin Exp Urol. 2021; 9(4):337-349. Yang JS, Qian C, You S, Rotinen M, Posadas EM, Freedland SJ, Di Vizio D, Kim J, Freeman MR. PMID: 34541032; PMCID: PMC8446770.
      View in: PubMed   Mentions: 1  
    11. Loss of CDCP1 triggers FAK activation in detached prostate cancer cells. Am J Clin Exp Urol. 2021; 9(4):350-366. Pollan SG, Teng PC, Jan YJ, Livingstone J, Huang C, Kim M, Mariscal J, Rodriguez M, Chen JF, You S, DiVizio D, Boutros PC, Chan KS, Rasorenova O, Cress A, Spassov D, Moasser M, Posadas EM, Freedland SJ, Freeman MR, Zheng JJ, Knudsen BS. PMID: 34541033; PMCID: PMC8446766.
      View in: PubMed   Mentions: 1  
    12. Building brain capital. Neuron. 2021 05 05; 109(9):1430-1432. Eyre HA, Ayadi R, Ellsworth W, Aragam G, Smith E, Dawson WD, Ibanez A, Altimus C, Berk M, Manji HK, Storch EA, Leboyer M, Kawaguchi N, Freeman M, Brannelly P, Manes F, Chapman SB, Cummings J, Graham C, Miller BF, Sarnyai Z, Meyer R, Hynes W. PMID: 33957073; PMCID: PMC8240507.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. A comparative study of PCS and PAM50 prostate cancer classification schemes. Prostate Cancer Prostatic Dis. 2021 09; 24(3):733-742. Yoon J, Kim M, Posadas EM, Freedland SJ, Liu Y, Davicioni E, Den RB, Trock BJ, Karnes RJ, Klein EA, Freeman MR, You S. PMID: 33531653; PMCID: PMC8326303.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma. Cancer Res. 2021 03 01; 81(5):1216-1229. Ma S, Zhou B, Yang Q, Pan Y, Yang W, Freedland SJ, Ding LW, Freeman MR, Breunig JJ, Bhowmick NA, Pan J, Koeffler HP, Lin DC. PMID: 33402390; PMCID: PMC8026506.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer. Clin Cancer Res. 2021 01 01; 27(1):320-329. Awasthi S, Berglund A, Abraham-Miranda J, Rounbehler RJ, Kensler K, Serna A, Vidal A, You S, Freeman MR, Davicioni E, Liu Y, Karnes RJ, Klein EA, Den RB, Trock BJ, Campbell JD, Einstein DJ, Gupta R, Balk S, Lal P, Park JY, Cleveland JL, Rebbeck TR, Freedland SJ, Yamoah K. PMID: 33037017; PMCID: PMC8042600.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    16. Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cell Mol Life Sci. 2021 Mar; 78(5):2341-2353. Sharma C, Yang W, Steen H, Freeman MR, Hemler ME. PMID: 32986127; PMCID: PMC8751980.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles. J Extracell Vesicles. 2020 Jun 10; 9(1):1764192. Mariscal J, Vagner T, Kim M, Zhou B, Chin A, Zandian M, Freeman MR, You S, Zijlstra A, Yang W, Di Vizio D. PMID: 32944167; PMCID: PMC7448892.
      View in: PubMed   Mentions: 16     Fields:    
    18. Combination Androgen Receptor Inhibition and Docetaxel in Metastatic Castration-sensitive Prostate Cancer: The Next Step in First-line Treatment? Clin Genitourin Cancer. 2020 12; 18(6):425-428. Adashek JJ, Reed JP, Tandon A, Freedland SJ, Posadas E, Bhowmick N, Chung LW, Freeman M, Figlin RA, Gong J. PMID: 32631766; PMCID: PMC9212901.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. BMC Cancer. 2020 May 07; 20(1):398. Miller ET, You S, Cadaneanu RM, Kim M, Yoon J, Liu ST, Li X, Kwan L, Hodge J, Quist MJ, Grasso CS, Lewis MS, Knudsen BS, Freeman MR, Garraway IP. PMID: 32380981; PMCID: PMC7204307.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Sex as a Determinant of Responses to a Coronary Artery Disease Self-Antigen Identified by Immune-Peptidomics. Front Immunol. 2020; 11:694. Lio WM, Cercek B, Yano J, Yang W, Ghermezi J, Zhao X, Zhou J, Zhou B, Freeman MR, Chyu KY, Shah PK, Dimayuga PC. PMID: 32373127; PMCID: PMC7187896.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    21. 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. Mol Cancer Res. 2020 05; 18(5):671-684. Dambal S, Alfaqih M, Sanders S, Maravilla E, Ramirez-Torres A, Galvan GC, Reis-Sobreiro M, Rotinen M, Driver LM, Behrove MS, Talisman TJ, Yoon J, You S, Turkson J, Chi JT, Freeman MR, Macias E, Freedland SJ. PMID: 32019810; PMCID: PMC7971119.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L429-L441. Hemnes AR, Fessel JP, Chen X, Zhu S, Fortune NL, Jetter C, Freeman M, Newman JH, West JD, Talati MH. PMID: 31850803; PMCID: PMC7052666.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Validation of a genomic classifier for prediction of metastasis and prostate cancer-specific mortality in African-American men following radical prostatectomy in an equal access healthcare setting. Prostate Cancer Prostatic Dis. 2020 09; 23(3):419-428. Howard LE, Zhang J, Fishbane N, Hoedt AM, Klaassen Z, Spratt DE, Vidal AC, Lin D, Hitchins MP, You S, Freeman MR, Yamoah K, Davicioni E, Freedland SJ. PMID: 31844180.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    24. Large and small extracellular vesicles released by glioma cells in vitro and in vivo. J Extracell Vesicles. 2020; 9(1):1689784. Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L. PMID: 31839905; PMCID: PMC6896449.
      View in: PubMed   Mentions: 30     Fields:    
    25. Highly oxidized low-density lipoprotein mediates activation of monocytes but does not confer interleukin-1β secretion nor interleukin-15 transpresentation function. Immunology. 2020 02; 159(2):221-230. Sieg SF, Bazdar DA, Zidar D, Freeman M, Lederman MM, Funderburg NT. PMID: 31663113; PMCID: PMC6954695.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Safety of Ixekizumab Treatment for up to 5 Years in Adult Patients with Moderate-to-Severe Psoriasis: Results from Greater Than 17,000 Patient-Years of Exposure. Dermatol Ther (Heidelb). 2020 Feb; 10(1):133-150. Armstrong A, Paul C, Puig L, Boehncke WH, Freeman M, Torii H, Papp K, Griffiths CEM, Blauvelt A, Reich K, Gooderham M, Terui T, Renda L, Agada N, Xu W, Gallo G, Lebwohl MG. PMID: 31749092; PMCID: PMC6994584.
      View in: PubMed   Mentions: 16  
    27. ONECUT2 as a new therapeutic target in androgen receptor-indifferent prostate cancer. Transl Cancer Res. 2019 Nov; 8(7):2677-2679. Freeman MR, Rotinen M, You S. PMID: 35117025; PMCID: PMC8798022.
      View in: PubMed   Mentions:
    28. Low-Background Acyl-Biotinyl Exchange Largely Eliminates the Coisolation of Non-S-Acylated Proteins and Enables Deep S-Acylproteomic Analysis. Anal Chem. 2019 08 06; 91(15):9858-9866. Zhou B, Wang Y, Yan Y, Mariscal J, Di Vizio D, Freeman MR, Yang W. PMID: 31251020; PMCID: PMC7451198.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Optimization of DNA extraction from human urinary samples for mycobiome community profiling. PLoS One. 2019; 14(4):e0210306. Ackerman AL, Anger JT, Khalique MU, Ackerman JE, Tang J, Kim J, Underhill DM, Freeman MR, NIH Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP). PMID: 31022216; PMCID: PMC6483181.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    30. A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. Theranostics. 2019; 9(10):2812-2826. Jan YJ, Yoon J, Chen JF, Teng PC, Yao N, Cheng S, Lozano A, Chu GCY, Chung H, Lu YT, Chen PJ, Wang JJ, Lee YT, Kim M, Zhu Y, Knudsen BS, Feng FY, Garraway IP, Gao AC, Chung LWK, Freeman MR, You S, Tseng HR, Posadas EM. PMID: 31244925; PMCID: PMC6568173.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    31. Quantitative proteomic analysis of prostate tissue specimens identifies deregulated protein complexes in primary prostate cancer. Clin Proteomics. 2019; 16:15. Zhou B, Yan Y, Wang Y, You S, Freeman MR, Yang W. PMID: 31011308; PMCID: PMC6461817.
      View in: PubMed   Mentions: 8  
    32. Keratin 8 is a potential self-antigen in the coronary artery disease immunopeptidome: A translational approach. PLoS One. 2019; 14(2):e0213025. Mihailovic PM, Lio WM, Herscovici R, Chyu KY, Yano J, Zhao X, Zhou J, Zhou B, Freeman MR, Yang W, Shah PK, Cercek B, Dimayuga PC. PMID: 30811493; PMCID: PMC6392305.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity. J Neurosci. 2019 04 10; 39(15):2951-2964. Ruhl D, Du TT, Wagner EL, Choi JH, Li S, Reed R, Kim K, Freeman M, Hashisaki G, Lukens JR, Shin JB. PMID: 30733218; PMCID: PMC6462451.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. A scalable filtration method for high throughput screening based on cell deformability. Lab Chip. 2019 01 15; 19(2):343-357. Gill NK, Ly C, Nyberg KD, Lee L, Qi D, Tofig B, Reis-Sobreiro M, Dorigo O, Rao J, Wiedemeyer R, Karlan B, Lawrenson K, Freeman MR, Damoiseaux R, Rowat AC. PMID: 30566156.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 12; 24(12):1887-1898. Rotinen M, You S, Yang J, Coetzee SG, Reis-Sobreiro M, Huang WC, Huang F, Pan X, Yáñez A, Hazelett DJ, Chu CY, Steadman K, Morrissey CM, Nelson PS, Corey E, Chung LWK, Freedland SJ, Di Vizio D, Garraway IP, Murali R, Knudsen BS, Freeman MR. PMID: 30478421; PMCID: PMC6614557.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    36. Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer. Cancers (Basel). 2018 Oct 11; 10(10). Sharma NV, Pellegrini KL, Ouellet V, Giuste FO, Ramalingam S, Watanabe K, Adam-Granger E, Fossouo L, You S, Freeman MR, Vertino P, Conneely K, Osunkoya AO, Trudel D, Mes-Masson AM, Petros JA, Saad F, Moreno CS. PMID: 30314329; PMCID: PMC6210624.
      View in: PubMed   Mentions: 13  
    37. Statin Therapy to Improve Prostate Cancer Outcomes: Who, When, and for How Long? Eur Urol. 2018 12; 74(6):702-703. Allott EH, Freeman MR, Freedland SJ. PMID: 30177293.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential. Cancer Res. 2018 11 01; 78(21):6086-6097. Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. PMID: 30154147.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J Extracell Vesicles. 2018; 7(1):1505403. Vagner T, Spinelli C, Minciacchi VR, Balaj L, Zandian M, Conley A, Zijlstra A, Freeman MR, Demichelis F, De S, Posadas EM, Tanaka H, Di Vizio D. PMID: 30108686; PMCID: PMC6084494.
      View in: PubMed   Mentions: 154     Fields:    
    40. Personalization of prostate cancer therapy through phosphoproteomics. Nat Rev Urol. 2018 08; 15(8):483-497. Yang W, Freeman MR, Kyprianou N. PMID: 29752463.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    41. Cardiac MRI and radionuclide ventriculography for measurement of left ventricular ejection fraction in ICD candidates. Magn Reson Imaging. 2018 10; 52:69-74. Kotha VK, Deva DP, Connelly KA, Freeman MR, Yan RT, Mangat I, Kirpalani A, Barfett JJ, Sloninko J, Lin HM, Graham JJ, Crean AM, Jimenez-Juan L, Dorian P, Yan AT. PMID: 29859946.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer. Prostate Cancer Prostatic Dis. 2018 06; 21(2):196-203. Allott EH, Masko EM, Freedland AR, Macias E, Pelton K, Solomon KR, Mostaghel EA, Thomas GV, Pizzo SV, Freeman MR, Freedland SJ. PMID: 29795142; PMCID: PMC6026483.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    43. Regulation of inside-out β1-integrin activation by CDCP1. Oncogene. 2018 05; 37(21):2817-2836. Pollan SG, Huang F, Sperger JM, Lang JM, Morrissey C, Cress AE, Chu CY, Bhowmick NA, You S, Freeman MR, Spassov DS, Moasser MM, Carter WG, Satapathy SR, Shah K, Knudsen BS. PMID: 29511352; PMCID: PMC6824599.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    44. Genes involved in prostate cancer progression determine MRI visibility. Theranostics. 2018; 8(7):1752-1765. Li P, You S, Nguyen C, Wang Y, Kim J, Sirohi D, Ziembiec A, Luthringer D, Lin SC, Daskivich T, Wu J, Freeman MR, Saouaf R, Li D, Kim HL. PMID: 29556354; PMCID: PMC5858498.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    45. Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. Cell Mol Gastroenterol Hepatol. 2018; 5(4):479-497. Waldron RT, Su HY, Piplani H, Capri J, Cohn W, Whitelegge JP, Faull KF, Sakkiah S, Abrol R, Yang W, Zhou B, Freeman MR, Pandol SJ, Lugea A. PMID: 29930975; PMCID: PMC6009017.
      View in: PubMed   Mentions: 12     Fields:    
    46. Serum cholesterol and risk of high-grade prostate cancer: results from the REDUCE study. Prostate Cancer Prostatic Dis. 2018 06; 21(2):252-259. Jamnagerwalla J, Howard LE, Allott EH, Vidal AC, Moreira DM, Castro-Santamaria R, Andriole GL, Freeman MR, Freedland SJ. PMID: 29282360; PMCID: PMC6021229.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    47. A Systems Approach to Prostate Cancer Classification-Response. Cancer Res. 2017 12 15; 77(24):7133-7135. You S, Freeman MR. PMID: 29212854.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Magnetic actuation and feedback cooling of a cavity optomechanical torque sensor. Nat Commun. 2017 11 07; 8(1):1355. Kim PH, Hauer BD, Clark TJ, Fani Sani F, Freeman MR, Davis JP. PMID: 29116095; PMCID: PMC5677085.
      View in: PubMed   Mentions: 2     Fields:    
    49. Diagnostic and prognostic significance of transient ischemic dilation (TID) in myocardial perfusion imaging: A systematic review and meta-analysis. J Nucl Cardiol. 2018 06; 25(3):724-737. Alama M, Labos C, Emery H, Iwanochko RM, Freeman M, Husain M, Lee DS. PMID: 28948540; PMCID: PMC5966496.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    50. Voice Outcomes in Surgical Repair of Zenker's Diverticulum. Dysphagia. 2017 Oct; 32(5):678-682. Schoeff S, Freeman M, Daniero J. PMID: 28540530.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    51. MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer. Cancer Res. 2017 05 01; 77(9):2306-2317. Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Mishra R, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D. PMID: 28202510.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    52. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 04 01; 77(7):1662-1673. Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Thompson JW, Dubois LG, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ. PMID: 28130224; PMCID: PMC5687884.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    53. Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells. Oncotarget. 2016 Dec 20; 7(51):84645-84657. Li Q, Yin L, Jones LW, Chu GC, Wu JB, Huang JM, Li Q, You S, Kim J, Lu YT, Mrdenovic S, Wang R, Freeman MR, Garraway I, Lewis MS, Chung LW, Zhau HE. PMID: 27835867; PMCID: PMC5356688.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    54. Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. Prostate. 2017 04; 77(5):446-457. Masko EM, Alfaqih MA, Solomon KR, Barry WT, Newgard CB, Muehlbauer MJ, Valilis NA, Phillips TE, Poulton SH, Freedland AR, Sun S, Dambal SK, Sanders SE, Macias E, Freeman MR, Dewhirst MW, Pizzo SV, Freedland SJ. PMID: 27900797; PMCID: PMC5822711.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
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    121. Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs. J Virol. 2010 Apr; 84(7):3270-9. Nkolola JP, Peng H, Settembre EC, Freeman M, Grandpre LE, Devoy C, Lynch DM, La Porte A, Simmons NL, Bradley R, Montefiori DC, Seaman MS, Chen B, Barouch DH. PMID: 20053749; PMCID: PMC2838122.
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    122. Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol Cell Proteomics. 2010 Jan; 9(1):54-70. Yang W, Di Vizio D, Kirchner M, Steen H, Freeman MR. PMID: 19801377; PMCID: PMC2808267.
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    123. Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: a substudy of the PARR-2 trial. JACC Cardiovasc Imaging. 2009 Sep; 2(9):1060-8. D'Egidio G, Nichol G, Williams KA, Guo A, Garrard L, deKemp R, Ruddy TD, DaSilva J, Humen D, Gulenchyn KY, Freeman M, Racine N, Benard F, Hendry P, Beanlands RS, PARR-2 Investigators. PMID: 19761983.
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    124. A first-in-man study of percutaneous myocardial cryotreatment in nonrevascularizable patients with refractory angina. Catheter Cardiovasc Interv. 2009 Sep 01; 74(3):387-94. Gallo R, Fefer P, Freeman M, Andrew P, Stewart DJ, Theroux P, Strauss BH. PMID: 19496148.
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    125. An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle. 2009 Aug; 8(15):2420-4. Di Vizio D, Morello M, Sotgia F, Pestell RG, Freeman MR, Lisanti MP. PMID: 19556867; PMCID: PMC2927821.
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    126. Growing evidence that radionuclide imaging identifies management strategies that improve outcome. J Nucl Cardiol. 2009 Nov-Dec; 16(6):844-5. Freeman MR. PMID: 19636650.
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    127. Proteomics and opportunities for clinical translation in urological disease. J Urol. 2009 Sep; 182(3):835-43. Vaezzadeh AR, Steen H, Freeman MR, Lee RS. PMID: 19616261; PMCID: PMC4370209.
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    128. Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res. 2009 Jul 01; 69(13):5601-9. Di Vizio D, Kim J, Hager MH, Morello M, Yang W, Lafargue CJ, True LD, Rubin MA, Adam RM, Beroukhim R, Demichelis F, Freeman MR. PMID: 19549916; PMCID: PMC2853876.
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    129. A signaling network in phenylephrine-induced benign prostatic hyperplasia. Endocrinology. 2009 Aug; 150(8):3576-83. Kim J, Yanagihara Y, Kikugawa T, Ji M, Tanji N, Masayoshi Y, Freeman MR. PMID: 19443575; PMCID: PMC2717887.
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    130. Cholesterol-regulated stress fiber formation. J Cell Biochem. 2009 Apr 15; 106(6):1031-40. Qi M, Liu Y, Freeman MR, Solomon KR. PMID: 19229870.
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    131. VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial. Mol Ther. 2009 Jun; 17(6):1109-15. Stewart DJ, Kutryk MJ, Fitchett D, Freeman M, Camack N, Su Y, Della Siega A, Bilodeau L, Burton JR, Proulx G, Radhakrishnan S, NORTHERN Trial Investigators. PMID: 19352324; PMCID: PMC2835194.
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    132. Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res. 2009 Mar 15; 69(6):2210-8. Mukhopadhyay NK, Kim J, Cinar B, Ramachandran A, Hager MH, Di Vizio D, Adam RM, Rubin MA, Raychaudhuri P, De Benedetti A, Freeman MR. PMID: 19258514; PMCID: PMC2659763.
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    133. Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol. 2009 Mar; 174(3):1017-26. Solomon KR, Pelton K, Boucher K, Joo J, Tully C, Zurakowski D, Schaffner CP, Kim J, Freeman MR. PMID: 19179610; PMCID: PMC2665761.
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    134. Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation. BJU Int. 2009 Feb; 103(4):541-6. Kim J, Keay SK, Freeman MR. PMID: 18990151; PMCID: PMC4000709.
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    135. Cholesterol and cholesterol-rich membranes in prostate cancer: an update. Tumori. 2008 Sep-Oct; 94(5):633-9. Di Vizio D, Solomon KR, Freeman MR. PMID: 19112935.
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    136. Optimizing sample handling for urinary proteomics. J Proteome Res. 2008 Sep; 7(9):4022-30. Lee RS, Monigatti F, Briscoe AC, Waldon Z, Freeman MR, Steen H. PMID: 18662026; PMCID: PMC5451898.
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    137. Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours. BMC Cancer. 2008 May 13; 8:134. Di Vizio D, Demichelis F, Simonetti S, Pettinato G, Terracciano L, Tornillo L, Freeman MR, Insabato L. PMID: 18474118; PMCID: PMC2396636.
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    138. Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle. 2008 Jul 15; 7(14):2257-67. Di Vizio D, Adam RM, Kim J, Kim R, Sotgia F, Williams T, Demichelis F, Solomon KR, Loda M, Rubin MA, Lisanti MP, Freeman MR. PMID: 18635971.
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    139. VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F60-72. Saban MR, Backer JM, Backer MV, Maier J, Fowler B, Davis CA, Simpson C, Wu XR, Birder L, Freeman MR, Soker S, Hurst RE, Saban R. PMID: 18463314; PMCID: PMC2494518.
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    140. Do the cholesterol-lowering properties of statins affect cancer risk? Trends Endocrinol Metab. 2008 May-Jun; 19(4):113-21. Solomon KR, Freeman MR. PMID: 18356074.
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    141. Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation. Proteomics. 2008 Mar; 8(5):1097-112. Lee RS, Monigatti F, Lutchman M, Patterson T, Budnik B, Steen JA, Freeman MR, Steen H. PMID: 18324733.
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    142. Proteomic approaches to the analysis of multiprotein signaling complexes. Proteomics. 2008 Feb; 8(4):832-51. Yang W, Steen H, Freeman MR. PMID: 18297654.
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    143. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31; 26(21):4523-34. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. PMID: 17932490; PMCID: PMC2063482.
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    144. F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2). J Am Coll Cardiol. 2007 Nov 13; 50(20):2002-12. Beanlands RS, Nichol G, Huszti E, Humen D, Racine N, Freeman M, Gulenchyn KY, Garrard L, deKemp R, Guo A, Ruddy TD, Benard F, Lamy A, Iwanochko RM, PARR-2 Investigators. PMID: 17996568.
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    145. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med. 2007 Oct 08; 167(18):1922-9. Dimitrakov J, Kroenke K, Steers WD, Berde C, Zurakowski D, Freeman MR, Jackson JL. PMID: 17923590; PMCID: PMC2135553.
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    146. The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Res. 2007 Oct 01; 67(19):9229-37. Kim J, Jahng WJ, Di Vizio D, Lee JS, Jhaveri R, Rubin MA, Shisheva A, Freeman MR. PMID: 17909029; PMCID: PMC3934554.
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    147. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem. 2007 Oct 05; 282(40):29584-93. Cinar B, Mukhopadhyay NK, Meng G, Freeman MR. PMID: 17635910.
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    148. p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett. 2007 Aug 07; 581(20):3795-9. Kim J, Keay SK, Dimitrakov JD, Freeman MR. PMID: 17628545; PMCID: PMC1939966.
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    149. Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res. 2007 Jul 01; 67(13):6238-46. Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Boucher K, Solomon KR, Freeman MR. PMID: 17616681.
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    150. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep; 21(9):2056-70. Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR. PMID: 17550981.
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    151. Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Cancer Biol Ther. 2007 Aug; 6(8):1263-8. Di Vizio D, Sotgia F, Williams TM, Hassan GS, Capozza F, Frank PG, Pestell RG, Loda M, Freeman MR, Lisanti MP. PMID: 17786030.
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    152. Beta2 microglobulin: a surprising therapeutic target for prostate cancer and renal cell carcinoma. J Urol. 2007 Jul; 178(1):10-1. Freeman MR. PMID: 17574050.
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    153. Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1319-25. Park YS, Kim J, Misonou Y, Takamiya R, Takahashi M, Freeman MR, Taniguchi N. PMID: 17363696.
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    154. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007 Feb; 22(2):274-85. Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA. PMID: 17129178; PMCID: PMC4548943.
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    155. Cardiac imaging for risk stratification in diabetes. Diabetes Care. 2007 May; 30(5):1295-304. Bax JJ, Inzucchi SE, Bonow RO, Schuijf JD, Freeman MR, Barrett EJ, Global Dialogue Group for the Evaluation of Cardiovascular Risk in Patients with Diabetes. PMID: 17259467.
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    156. Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids. 2007 Feb; 72(2):210-7. Freeman MR, Cinar B, Kim J, Mukhopadhyay NK, Di Vizio D, Adam RM, Solomon KR. PMID: 17173942; PMCID: PMC2709209.
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    157. Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate development. Am J Pathol. 2006 Dec; 169(6):2209-22. Fang PK, Solomon KR, Zhuang L, Qi M, McKee M, Freeman MR, Yelick PC. PMID: 17148682; PMCID: PMC1762473.
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    158. Left ventricular function during arm exercise: influence of leg cycling and lower body positive pressure. J Appl Physiol (1985). 2007 Mar; 102(3):904-12. Goodman JM, Freeman MR, Goodman LS. PMID: 17138838.
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    159. Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. Lab Invest. 2006 Dec; 86(12):1293-302. Estrada CR, Adam RM, Eaton SH, Bägli DJ, Freeman MR. PMID: 17043666.
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    160. Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen. Clinics (Sao Paulo). 2006 Oct; 61(5):401-8. Duque JL, Loughlin KR, Adam RM, Kantoff P, Mazzucchi E, Freeman MR. PMID: 17072437.
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    161. Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem. 2006 Dec 01; 281(48):36883-90. Kim KW, Mutter RW, Cao C, Albert JM, Freeman M, Hallahan DE, Lu B. PMID: 17005556.
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    162. Drug delivery systems in urology--getting "smarter". Urology. 2006 Sep; 68(3):463-9. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. PMID: 17010721; PMCID: PMC1618825.
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    163. Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. Exp Cell Res. 2006 Nov 15; 312(19):3782-95. Mukhopadhyay NK, Ferdinand AS, Mukhopadhyay L, Cinar B, Lutchman M, Richie JP, Freeman MR, Liu BC. PMID: 17011549.
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    164. The role of cholesterol in prostate cancer. Curr Opin Clin Nutr Metab Care. 2006 Jul; 9(4):379-85. Hager MH, Solomon KR, Freeman MR. PMID: 16778565.
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    165. Statins and the risk of cancer. JAMA. 2006 Jun 21; 295(23):2720-1; author reply 2721-2. Freeman MR, Solomon KR, Moyad M. PMID: 16788122.
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    166. Management of chronic prostatitis/chronic pelvic pain syndrome: an evidence-based approach. Urology. 2006 May; 67(5):881-8. Dimitrakov JD, Kaplan SA, Kroenke K, Jackson JL, Freeman MR. PMID: 16698346; PMCID: PMC1463048.
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    167. Behavioral profiling of human transitional cell carcinoma ex vivo. Cancer Res. 2006 Mar 15; 66(6):3078-86. Estrada CR, Salanga M, Bielenberg DR, Harrell WB, Zurakowski D, Zhu X, Palmer MR, Freeman MR, Adam RM. PMID: 16540657.
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    168. Myocardial perfusion imaging in diabetes mellitus. Can J Cardiol. 2006 Feb; 22 Suppl A:22A-25A. Freeman M. PMID: 16485056.
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    169. A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics. 2005 Dec; 5(18):4733-42. MacLellan DL, Steen H, Adam RM, Garlick M, Zurakowski D, Gygi SP, Freeman MR, Solomon KR. PMID: 16267816.
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    170. Clusterin as a therapeutic target for radiation sensitization in a lung cancer model. Int J Radiat Oncol Biol Phys. 2005 Nov 15; 63(4):1228-36. Cao C, Shinohara ET, Li H, Niermann KJ, Kim KW, Sekhar KR, Gleave M, Freeman M, Lu B. PMID: 16253777.
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    171. Trafficking of nuclear heparin-binding epidermal growth factor-like growth factor into an epidermal growth factor receptor-dependent autocrine loop in response to oxidative stress. Cancer Res. 2005 Sep 15; 65(18):8242-9. Kim J, Adam RM, Freeman MR. PMID: 16166300.
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    172. Tumor cell-associated neuropilin-1 and vascular endothelial growth factor expression as determinants of tumor growth in neuroblastoma. Neuropathology. 2005 Sep; 25(3):178-87. Marcus K, Johnson M, Adam RM, O'Reilly MS, Donovan M, Atala A, Freeman MR, Soker S. PMID: 16193833.
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    173. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab. 2005 Aug; 16(6):273-9. Freeman MR, Cinar B, Lu ML. PMID: 16002302.
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    174. Increasing the ranks of physician-scientists in urology through the promotion of fellowship training: the example of pediatric urology. J Urol. 2005 Jun; 173(6):2110-1. Koh CJ, Freeman MR, Retik AB. PMID: 15879860.
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    175. Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin. Cancer Res. 2005 Apr 01; 65(7):2547-53. Cinar B, De Benedetti A, Freeman MR. PMID: 15805247.
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    176. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest. 2005 Apr; 115(4):959-68. Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR. PMID: 15776112; PMCID: PMC1064980.
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    177. Growth and stretch response of human exstrophy bladder smooth muscle cells: molecular evidence of normal intrinsic function. BJU Int. 2005 Jan; 95(1):144-8. Orsola A, Estrada CR, Nguyen HT, Retik AB, Freeman MR, Peters CA, Adam RM. PMID: 15638913.
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    178. An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding. J Cell Biochem. 2005 Jan 01; 94(1):39-49. Kim J, Lin J, Adam RM, Lamb C, Shively SB, Freeman MR. PMID: 15490481.
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    179. Caveolae are negative regulators of transforming growth factor-beta1 signaling in ureteral smooth muscle cells. J Urol. 2004 Dec; 172(6 Pt 1):2451-5. Stehr M, Estrada CR, Khoury J, Danciu TE, Sullivan MP, Peters CA, Solomon KR, Freeman MR, Adam RM. PMID: 15538289.
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    180. HER2/HER3 heterodimers in prostate cancer: Whither HER1/EGFR? Cancer Cell. 2004 Nov; 6(5):427-8. Freeman MR. PMID: 15542423.
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    181. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics. 2004 Dec 15; 20(1):36-44. Adam RM, Eaton SH, Estrada C, Nimgaonkar A, Shih SC, Smith LE, Kohane IS, Bägli D, Freeman MR. PMID: 15467014.
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    182. Mechanical strain delivers anti-apoptotic and proliferative signals to gingival fibroblasts. J Dent Res. 2004 Aug; 83(8):596-601. Danciu TE, Gagari E, Adam RM, Damoulis PD, Freeman MR. PMID: 15271966.
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    183. Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells. Biochem J. 2004 Apr 15; 379(Pt 2):421-31. Cinar B, Yeung F, Konaka H, Mayo MW, Freeman MR, Zhau HE, Chung LW. PMID: 14715080; PMCID: PMC1224078.
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    184. Survivin as a therapeutic target for radiation sensitization in lung cancer. Cancer Res. 2004 Apr 15; 64(8):2840-5. Lu B, Mu Y, Cao C, Zeng F, Schneider S, Tan J, Price J, Chen J, Freeman M, Hallahan DE. PMID: 15087401.
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    185. Cholesterol and prostate cancer. J Cell Biochem. 2004 Jan 01; 91(1):54-69. Freeman MR, Solomon KR. PMID: 14689582.
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    186. Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinology. 2004 Feb; 145(2):613-9. Kim J, Adam RM, Solomon KR, Freeman MR. PMID: 14563701.
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    187. Endocardial cryotherapy as a novel strategy of improving myocardial perfusion in a patient with severe coronary artery disease. Catheter Cardiovasc Interv. 2003 Oct; 60(2):229-32. Segev A, Strauss BH, Coates G, Freeman MR, Gallo R. PMID: 14517931.
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    188. Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells. J Urol. 2003 Jun; 169(6):2388-93. Adam RM, Roth JA, Cheng HL, Rice DC, Khoury J, Bauer SB, Peters CA, Freeman MR. PMID: 12771803.
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    189. JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2003 Jun; 79(3):321-8. Kim J, Freeman MR. PMID: 12846416.
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    190. Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. J Urol. 2003 Mar; 169(3):1165-70. Stehr M, Adam RM, Khoury J, Zhuang L, Solomon KR, Peters CA, Freeman MR. PMID: 12576874.
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    191. Left ventricular performance during acute rate control in atrial fibrillation: the importance of heart rate and agent used. J Cardiovasc Pharmacol Ther. 2003 Mar; 8(1):17-24. Pinter A, Dorian P, Paquette M, Ng A, Burns M, Spanu I, Freeman M, Korley V, Newman D. PMID: 12652326.
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    192. Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 2003 Feb 11; 536(1-3):193-7. Danciu TE, Adam RM, Naruse K, Freeman MR, Hauschka PV. PMID: 12586362.
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    193. A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional cell carcinoma. Cancer Res. 2003 Jan 15; 63(2):484-90. Adam RM, Danciu T, McLellan DL, Borer JG, Lin J, Zurakowski D, Weinstein MH, Rajjayabun PH, Mellon JK, Freeman MR. PMID: 12543806.
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    194. Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cells. Prostate. 2003 Jan 01; 54(1):1-7. Lin J, Freeman MR. PMID: 12481249.
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    195. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest. 2002 Dec; 82(12):1755-64. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR. PMID: 12480925.
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    196. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am Heart J. 2002 Jun; 143(6):1092-100. Jeejeebhoy F, Keith M, Freeman M, Barr A, McCall M, Kurian R, Mazer D, Errett L. PMID: 12075268.
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    197. The decision to undergo DNA or protein synthesis is determined by the degree of mechanical deformation in human bladder muscle cells. Urology. 2002 May; 59(5):779-83. Orsola A, Adam RM, Peters CA, Freeman MR. PMID: 11992928.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    198. Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses. J Am Coll Cardiol. 2002 Mar 20; 39(6):991-8. Emmett L, Iwanochko RM, Freeman MR, Barolet A, Lee DS, Husain M. PMID: 11897441.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    199. Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Res. 2002 Mar 01; 62(5):1549-54. Kim J, Adam RM, Freeman MR. PMID: 11888934.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    200. Male partner screening before in vitro fertilization: preselecting patients who require intracytoplasmic sperm injection with the sperm penetration assay. Fertil Steril. 2001 Dec; 76(6):1113-8. Freeman MR, Archibong AE, Mrotek JJ, Whitworth CM, Weitzman GA, Hill GA. PMID: 11730736.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    201. Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS. Development. 2001 Oct; 128(20):4103-12. Freeman MR, Doe CQ. PMID: 11641232.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    202. BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation. J Biol Chem. 2001 Aug 10; 276(32):30127-32. Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR. PMID: 11340068.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    203. Effects of rhythm regularization and rate control in improving left ventricular function in atrial fibrillation patients undergoing atrioventricular nodal ablation. Can J Cardiol. 2001 Apr; 17(4):437-45. Verma A, Newman D, Geist M, Greenhut S, Laslop J, DeBellis L, Freeman MR, Dorian P. PMID: 11329544.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    204. Prognostic value of dipyridamole SPECT imaging in low-risk patients after myocardial infarction. J Nucl Cardiol. 2001 Mar-Apr; 8(2):136-43. Chiamvimonvat V, Goodman SG, Langer A, Barr A, Freeman MR. PMID: 11295690.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    205. Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro. J Urol. 2001 Jan; 165(1):284-8. Duque JL, Adam RM, Mullen JS, Lin J, Richie JP, Freeman MR. PMID: 11125426.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    206. Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1155-67. Nguyen HT, Adam RM, Bride SH, Park JM, Peters CA, Freeman MR. PMID: 11003596.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    207. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. Am J Pathol. 2000 Mar; 156(3):889-98. Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA. PMID: 10702406; PMCID: PMC1876861.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    208. A nontoxic diphtheria toxin analogue inhibits neonatal bladder smooth muscle cell proliferation. J Urol. 2000 Feb; 163(2):580-4. Kaefer M, Vemulapalli S, Freeman MR. PMID: 10647689.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    209. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. Endocrinology. 1999 Dec; 140(12):5866-75. Adam RM, Borer JG, Williams J, Eastham JA, Loughlin KR, Freeman MR. PMID: 10579352.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    210. The effects of sustained hydrostatic pressure on select bladder smooth muscle cell functions. J Urol. 1999 Dec; 162(6):2114-8. Haberstroh KM, Kaefer M, Retik AB, Freeman MR, Bizios R. PMID: 10569598.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    211. Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction. Lab Invest. 1999 Nov; 79(11):1335-45. Borer JG, Park JM, Atala A, Nguyen HT, Adam RM, Retik AB, Freeman MR. PMID: 10576204.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    212. Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. Urology. 1999 Sep; 54(3):523-7. Duque JL, Loughlin KR, Adam RM, Kantoff PW, Zurakowski D, Freeman MR. PMID: 10475365.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    213. Oxybutynin chloride inhibits proliferation and suppresses gene expression in bladder smooth muscle cells. J Urol. 1999 Sep; 162(3 Pt 2):1110-4. Park JM, Bauer SB, Freeman MR, Peters CA. PMID: 10458442.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    214. AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. Am J Physiol. 1999 08; 277(2):C294-301. Park JM, Adam RM, Peters CA, Guthrie PD, Sun Z, Klagsbrun M, Freeman MR. PMID: 10444406.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    215. Cell-specific activation of the HB-EGF and ErbB1 genes by stretch in primary human bladder cells. In Vitro Cell Dev Biol Anim. 1999 Jul-Aug; 35(7):371-5. Nguyen HT, Park JM, Peters CA, Adam RM, Orsola A, Atala A, Freeman MR. PMID: 10462199.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    216. The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res. 1999 Jun 15; 59(12):2891-7. Lin J, Adam RM, Santiestevan E, Freeman MR. PMID: 10383151.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    217. A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron. 1999 Feb; 22(2):327-38. Clyne PJ, Warr CG, Freeman MR, Lessing D, Kim J, Carlson JR. PMID: 10069338.
      View in: PubMed   Mentions: 352     Fields:    Translation:AnimalsCells
    218. Obstruction stimulates COX-2 expression in bladder smooth muscle cells via increased mechanical stretch. Am J Physiol. 1999 01; 276(1):F129-36. Park JM, Yang T, Arend LJ, Schnermann JB, Peters CA, Freeman MR, Briggs JP. PMID: 9887088.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    219. Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells. Am J Physiol. 1998 11; 275(5):C1247-54. Park JM, Borer JG, Freeman MR, Peters CA. PMID: 9814973.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    220. Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J Cell Biochem. 1998 May 01; 69(2):143-53. Dethlefsen SM, Raab G, Moses MA, Adam RM, Klagsbrun M, Freeman MR. PMID: 9548562.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    221. Increased incidence of matrix metalloproteinases in urine of cancer patients. Cancer Res. 1998 Apr 01; 58(7):1395-9. Moses MA, Wiederschain D, Loughlin KR, Zurakowski D, Lamb CC, Freeman MR. PMID: 9537238.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    222. Heparin-binding EGF-like growth factor in the human prostate: synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen. J Cell Biochem. 1998 Mar 01; 68(3):328-38. Freeman MR, Paul S, Kaefer M, Ishikawa M, Adam RM, Renshaw AA, Elenius K, Klagsbrun M. PMID: 9518259.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    223. Clinical comparison of 180-degree and 360-degree data collection of technetium 99m sestamibi SPECT for detection of coronary artery disease. J Nucl Cardiol. 1998 Jan-Feb; 5(1):14-8. Freeman MR, Konstantinou C, Barr A, Greyson ND. PMID: 9504868.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    224. Relation of direct assessment of cardiac autonomic function with metaiodobenzylguanidine imaging to heart rate variability in diabetes mellitus. Am J Cardiol. 1997 Jul 15; 80(2):247-50. Freeman MR, Newman D, Dorian P, Barr A, Langer A. PMID: 9230179.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    225. Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease. Am J Physiol. 1997 Jun; 272(6 Pt 2):R1960-5. Peters CA, Freeman MR, Fernandez CA, Shepard J, Wiederschain DG, Moses MA. PMID: 9227614.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    226. Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest. 1997 Mar 01; 99(5):1028-36. Freeman MR, Yoo JJ, Raab G, Soker S, Adam RM, Schneck FX, Renshaw AA, Klagsbrun M, Atala A. PMID: 9062361; PMCID: PMC507911.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    227. Human albumin solder supplemented with TGF-beta 1 accelerates healing following laser welded wound closure. Lasers Surg Med. 1996; 19(3):360-8. Poppas DP, Massicotte JM, Stewart RB, Roberts AB, Atala A, Retik AB, Freeman MR. PMID: 8923433.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    228. Temperature-controlled laser photocoagulation of soft tissue: in vivo evaluation using a tissue welding model. Lasers Surg Med. 1996; 18(4):335-44. Poppas DP, Stewart RB, Massicotte JM, Wolga AE, Kung RT, Retik AB, Freeman MR. PMID: 8732572.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    229. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res. 1995 Sep 15; 55(18):4140-5. Freeman MR, Schneck FX, Gagnon ML, Corless C, Soker S, Niknejad K, Peoples GE, Klagsbrun M. PMID: 7545086.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    230. T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role. Proc Natl Acad Sci U S A. 1995 Jul 03; 92(14):6547-51. Peoples GE, Blotnick S, Takahashi K, Freeman MR, Klagsbrun M, Eberlein TJ. PMID: 7604030; PMCID: PMC41555.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    231. Expression of cell growth regulated genes in the fetal kidney: relevance to in utero obstruction. J Urol. 1995 Jul; 154(1):242-6. Carr MC, Schlussel RN, Peters CA, Uchida T, Mandell J, Freeman MR. PMID: 7776438.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    232. Usefulness of ischemic response to mental stress in predicting silent myocardial ischemia during ambulatory monitoring. Am J Cardiol. 1995 May 15; 75(15):1007-11. Legault SE, Langer A, Armstrong PW, Freeman MR. PMID: 7747678.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    233. Pathophysiology and time course of silent myocardial ischaemia during mental stress: clinical, anatomical, and physiological correlates. Br Heart J. 1995 Mar; 73(3):242-9. Legault SE, Freeman MR, Langer A, Armstrong PW. PMID: 7727184; PMCID: PMC483806.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    234. Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia. J Am Coll Cardiol. 1995 Mar 01; 25(3):610-8. Langer A, Freeman MR, Josse RG, Armstrong PW. PMID: 7860904.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    235. Detection of silent ischemia adds to the prognostic value of coronary anatomy and left ventricular function in predicting outcome in unstable angina patients. Can J Cardiol. 1995 Feb; 11(2):117-22. Langer A, Singh N, Freeman MR, Tibshirani R, Armstrong PW. PMID: 7866934.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    236. Northern exposure: nuclear cardiology in the Canadian health care system. J Nucl Cardiol. 1995 Jan-Feb; 2(1):53-61. Miller DD, Kiess MC, Freeman MR, Taillefer R. PMID: 9420762.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    237. Measurement of left ventricular function during arm ergometry using the VEST nuclear probe. Can J Appl Physiol. 1994 Dec; 19(4):462-71. Goodman LS, Goodman JM, Yang L, Sloninko J, Hsia T, Freeman MR. PMID: 7849662.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    238. Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro. J Urol. 1994 Aug; 152(2 Pt 2):665-70. Cilento BG, Freeman MR, Schneck FX, Retik AB, Atala A. PMID: 7517459.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    239. Frequency of transient reductions in left ventricular ejection fraction at rest in coronary artery disease. Am J Cardiol. 1994 Jul 15; 74(2):137-43. Freeman MR, de Yang L, Langer A, Foley B, Armstrong PW. PMID: 8023777.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    240. Increased G-suit coverage improves cardiac preloading conditions during positive pressure breathing. Aviat Space Environ Med. 1994 Jul; 65(7):632-40. Goodman LS, Freeman MR, de Yang L, Hsia TW, Chan J. PMID: 7945131.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    241. Abnormalities of cardiac sympathetic function in pacing-induced heart failure as assessed by [123I]metaiodobenzylguanidine scintigraphy. Circulation. 1994 Jun; 89(6):2843-51. Simmons WW, Freeman MR, Grima EA, Hsia TW, Armstrong PW. PMID: 8205700.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    242. Does ambulatory monitoring contribute to exercise testing and myocardial perfusion scintigraphy in the prediction of the extent of coronary artery disease in stable angina? Am J Cardiol. 1994 Apr 15; 73(11):747-52. Goodman SG, Freeman MR, Armstrong PW, Langer A. PMID: 8160610.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    243. T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):2890-94. Blotnick S, Peoples GE, Freeman MR, Eberlein TJ, Klagsbrun M. PMID: 7909156; PMCID: PMC43479.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    244. Detection of human androgen receptor mRNA expression abnormalities by competitive PCR. DNA Cell Biol. 1994 Mar; 13(3):265-73. Edelstein RA, Carr MC, Caesar R, Young M, Atala A, Freeman MR. PMID: 7909666.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    245. Culture of a prostatic cell line in basement membrane gels results in an enhancement of malignant properties and constitutive alterations in gene expression. J Cell Physiol. 1994 Feb; 158(2):325-36. Freeman MR, Bagli DJ, Lamb CC, Guthrie PD, Uchida T, Slavin RE, Chung LW. PMID: 8106569.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    246. Myocardial alterations during hemodialysis: insights from new noninvasive technology. Am J Nephrol. 1994; 14(3):173-81. Singh N, Langer A, Freeman MR, Goldstein MB. PMID: 7977476.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    247. Implantation in vivo and retrieval of artificial structures consisting of rabbit and human urothelium and human bladder muscle. J Urol. 1993 Aug; 150(2 Pt 2):608-12. Atala A, Freeman MR, Vacanti JP, Shepard J, Retik AB. PMID: 8326605.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    248. Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May; 43(5):1081-5. Atala A, Freeman MR, Mandell J, Beier DR. PMID: 8510385.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    249. Patients with symptomatic ischemia have larger thallium perfusion abnormalities and more adverse prognosis than patients with silent ischemia. Can J Cardiol. 1992 Oct; 8(8):814-8. Hendler AL, Greyson ND, Robinson MG, Freeman MR. PMID: 1423002.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    250. Reverse redistribution on exercise thallium scintigraphy: relationship to coronary patency and ventricular function after myocardial infarction. Can J Cardiol. 1992 Sep; 8(7):709-15. Langer A, Burns RJ, Freeman MR, Liu P, Morgan CD, Wilson R, Armstrong PW. PMID: 1422991.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
    251. Formation of urothelial structures in vivo from dissociated cells attached to biodegradable polymer scaffolds in vitro. J Urol. 1992 Aug; 148(2 Pt 2):658-62. Atala A, Vacanti JP, Peters CA, Mandell J, Retik AB, Freeman MR. PMID: 1322466.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    252. Acute reduction of lipoprotein(a) by tissue-type plasminogen activator. Circulation. 1992 Jun; 85(6):2034-8. Hegele RA, Freeman MR, Langer A, Connelly PW, Armstrong PW. PMID: 1534287.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    253. Thrombolysis in unstable angina. Randomized double-blind trial of t-PA and placebo. Circulation. 1992 Jan; 85(1):150-7. Freeman MR, Langer A, Wilson RF, Morgan CD, Armstrong PW. PMID: 1728444.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    254. Detection of silent myocardial ischemia in diabetes mellitus. Am J Cardiol. 1991 May 15; 67(13):1073-8. Langer A, Freeman MR, Josse RG, Steiner G, Armstrong PW. PMID: 2024596.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    255. Extracellular matrix and androgen receptor expression associated with spontaneous transformation of rat prostate fibroblasts. Cancer Res. 1991 Apr 01; 51(7):1910-6. Freeman MR, Song Y, Carson DD, Guthrie PD, Chung LW. PMID: 2004375.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    256. Ultrastructural studies of unstable angina in living man. Mod Pathol. 1991 Jan; 4(1):75-80. Gotlieb AI, Freeman MR, Salerno TA, Lichtenstein SV, Armstrong PW. PMID: 2020665.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    257. Relation of angiographic detected intracoronary thrombus and silent myocardial ischemia in unstable angina pectoris. Am J Cardiol. 1990 Dec 01; 66(19):1381-2. Langer A, Freeman MR, Armstrong PW. PMID: 2244574.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    258. Prognosis in medically stabilized unstable angina: early Holter ST-segment monitoring compared with predischarge exercise thallium tomography. Ann Intern Med. 1990 Oct 15; 113(8):575-9. Marmur JD, Freeman MR, Langer A, Armstrong PW. PMID: 2400166.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    259. Regulation of gene expression in rat prostate by androgen and beta-adrenergic receptor pathways. Mol Endocrinol. 1990 Sep; 4(9):1343-53. Guthrie PD, Freeman MR, Liao ST, Chung LW. PMID: 2172800.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    260. Left ventricular diastolic volume changes by exercise radionuclide ventriculography in normal subjects and in patients with coronary arterial narrowing. Am J Cardiol. 1990 Mar 15; 65(11):826. Freeman MR. PMID: 2316471.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    261. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):75-9. Camps JL, Chang SM, Hsu TC, Freeman MR, Hong SJ, Zhau HE, von Eschenbach AC, Chung LW. PMID: 2296606; PMCID: PMC53202.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    262. Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers. Cancer Res. 1989 Nov 15; 49(22):6221-5. Freeman MR, Washecka R, Chung LW. PMID: 2572319.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    263. New etiology for intestinal uptake of thallium-201. Clin Nucl Med. 1989 Oct; 14(10):764-6. Morrison M, Fairholm S, Freeman MR. PMID: 2805528.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    264. Intracoronary thrombus and complex morphology in unstable angina. Relation to timing of angiography and in-hospital cardiac events. Circulation. 1989 Jul; 80(1):17-23. Freeman MR, Williams AE, Chisholm RJ, Armstrong PW. PMID: 2736749.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    265. ST segment shift in unstable angina: pathophysiology and association with coronary anatomy and hospital outcome. J Am Coll Cardiol. 1989 Jun; 13(7):1495-502. Langer A, Freeman MR, Armstrong PW. PMID: 2786015.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic Health
    266. Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction. J Am Coll Cardiol. 1989 Jun; 13(7):1469-76. Armstrong PW, Baigrie RS, Daly PA, Haq A, Gent M, Roberts RS, Freeman MR, Burns R, Liu P, Morgan CD. PMID: 2498414.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    267. Regulation of the S100 protein and GFAP genes is mediated by two common mechanisms in RT4 neuro-glial cell lines. Exp Cell Res. 1989 Jun; 182(2):370-83. Freeman MR, Beckmann SL, Sueoka N. PMID: 2542069.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    268. Changes in jugular venous flow velocity after coronary artery bypass grafting. Am J Cardiol. 1989 Mar 15; 63(11):725-9. Ranganathan N, Sivaciyan V, Pryszlak M, Freeman MR. PMID: 2646898.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    269. Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris. Am Heart J. 1989 Feb; 117(2):306-14. Freeman MR, Williams AE, Chisholm RJ, Patt NL, Greyson ND, Armstrong PW. PMID: 2916406.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    270. Comparison of rest and exercise thallium-201 kinetics in man and implications for quantitation. Am J Physiol Imaging. 1989; 4(1):4-10. Freeman MR, Kanwar N, Armstrong PW. PMID: 2923722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    271. Usefulness of exercise electrocardiography and thallium scintigraphy in unstable angina pectoris in predicting the extent and severity of coronary artery disease. Am J Cardiol. 1988 Dec 01; 62(17):1164-70. Freeman MR, Chisholm RJ, Armstrong PW. PMID: 3195477.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    272. Angiographic morphology in unstable angina pectoris. Am J Cardiol. 1988 Nov 15; 62(16):1024-7. Williams AE, Freeman MR, Chisholm RJ, Patt NL, Armstrong PW. PMID: 3189165.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    273. Simplified application of Bayesian analysis to multiple cardiologic tests. Clin Cardiol. 1982 Dec; 5(12):630-6. Staniloff HM, Diamond GA, Freeman MR, Berman DS, Forrester JS. PMID: 7151350.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    274. Comparison of upright and supine bicycle exercise in the detection and evaluation of extent of coronary artery disease by equilibrium radionuclide ventriculography. Am Heart J. 1981 Aug; 102(2):182-9. Freeman MR, Berman DS, Staniloff H, Elkayam U, Maddahi J, Swan HJ, Forrester J. PMID: 7258091.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    275. Improved assessment of inferior segmental wall motion by the addition of a 70-degree left anterior oblique view in multiple gated equilibrium scintigraphy. Am Heart J. 1981 Feb; 101(2):169-73. Freeman MR, Berman DS, Staniloff HM, Waxman AD, Maddahi J, Buchbinder NA, Forrester JS, Swan HJ. PMID: 7468418.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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