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Yeaman Michael R

Title(s)Director, Integrative center for inflammation
SchoolHarbor-UCLA Medical Center
Phone(310) 222-6428
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    Other Positions
    Title(s)Associate Director, Adult Infectious Diseases Training Program

    Title(s)Vice Chair, Medical Sciences

    Title(s)Professor, Infectious Diseases

    Title(s)Professor, Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kohler C, Proctor RA, Bayer AS, Yeaman MR, Lalk M, Engelmann S, Mishra NN. Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide. Antibiotics (Basel). 2019 Sep 28; 8(4). PMID: 31569354.
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    2. Mba Medie F, Sharma-Kuinkel BK, Ruffin F, Chan LC, Rossetti M, Chang YL, Park LP, Bayer AS, Filler SG, Ahn R, Reed EF, Gjertson D, Yeaman MR, Fowler VG. Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients. Proc Natl Acad Sci U S A. 2019 Sep 16. PMID: 31527248.
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    3. Mikkaichi T, Yeaman MR, Hoffmann A. Identifying determinants of persistent MRSA bacteremia using mathematical modeling. PLoS Comput Biol. 2019 Jul; 15(7):e1007087. PMID: 31295255.
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    4. Cook LJ, Rose JW, Alvey JS, Jolley AM, Kuhn R, Marron B, Pederson M, Enriquez R, Yearley J, McKechnie S, Han MH, Tomczak AJ, Levy M, Mealy MA, Coleman J, Bennett JL, Johnson R, Barnes-Garcia M, Traboulsee AL, Carruthers RL, Lee LE, Schubert JJ, McMullen K, Kister I, Rimler Z, Reid A, Sicotte NL, Planchon SM, Cohen JA, Ivancic D, Sedlak JL, Sand IK, Repovic P, Amezcua L, Pruitt A, Amundson E, Chitnis T, Mullin DS, Klawiter EC, Russo AW, Riley CS, Onomichi KB, Levine L, Nelson KE, Nealon NM, Engel C, Kruse-Hoyer M, Marcille M, Tornes L, Rumpf A, Greer A, Kenneally Behne M, Rodriguez RR, Behne DW, Blackway DW, Coords B, Blaschke TF, Sheard J, Smith TJ, Behne JM, Yeaman MR. Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD. Neurol Neuroimmunol Neuroinflamm. 2019 Sep; 6(5):e583. PMID: 31355319.
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    5. Beekman J, Keisler A, Pedraza O, Haramura M, Gianella-Borradori A, Katz E, Ratchford JN, Barron G, Cook LJ, Behne JM, Blaschke TF, Smith TJ, Yeaman MR. Neuromyelitis optica spectrum disorder: Patient experience and quality of life. Neurol Neuroimmunol Neuroinflamm. 2019 Jul; 6(4):e580. PMID: 31355316.
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    6. Li L, Yeaman MR, Bayer AS, Xiong YQ. Phenotypic and Genotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Related to Persistent Endovascular Infection. Antibiotics (Basel). 2019 May 29; 8(2). PMID: 31146412.
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    7. Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, Cai SS, Limjunyawong N, Dong X, Yeaman MR, Simon SI, Shen W, Durum SK, O'Brien RL, Maverakis E, Miller LS. Clonal V?6+Vd4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection. Proc Natl Acad Sci U S A. 2019 May 28; 116(22):10917-10926. PMID: 31088972.
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    8. Yount NY, Weaver DC, Lee EY, Lee MW, Wang H, Chan LC, Wong GCL, Yeaman MR. Unifying structural signature of eukaryotic a-helical host defense peptides. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6944-6953. PMID: 30877253.
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    9. Tradtrantip L, Duan T, Yeaman MR, Verkman AS. CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2019 Mar 09; 16(1):57. PMID: 30851734.
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    10. Chan LC, Rossetti M, Miller LS, Filler SG, Johnson CW, Lee HK, Wang H, Gjertson D, Fowler VG, Reed EF, Yeaman MR. Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11111-E11119. PMID: 30297395.
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    11. Li L, Abdelhady W, Donegan NP, Seidl K, Cheung A, Zhou YF, Yeaman MR, Bayer AS, Xiong YQ. Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection. J Infect Dis. 2018 09 22; 218(9):1367-1377. PMID: 29868791.
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    12. Uppuluri P, Singh S, Alqarihi A, Schmidt CS, Hennessey JP, Yeaman MR, Filler SG, Edwards JE, Ibrahim AS. Human Anti-Als3p Antibodies Are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis. Front Immunol. 2018; 9:1349. PMID: 29963049.
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    13. Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K. Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell. 2018 06 14; 5(7):300-326. PMID: 29992128.
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    14. Edwards JE, Schwartz MM, Schmidt CS, Sobel JD, Nyirjesy P, Schodel F, Marchus E, Lizakowski M, DeMontigny EA, Hoeg J, Holmberg T, Cooke MT, Hoover K, Edwards L, Jacobs M, Sussman S, Augenbraun M, Drusano M, Yeaman MR, Ibrahim AS, Filler SG, Hennessey JP. A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial. Clin Infect Dis. 2018 06 01; 66(12):1928-1936. PMID: 29697768.
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    15. Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef EG, Alkhazraji S, Yount NY, Ibrahim BA, Bolaris MA, Edwards JE, Swidergall M, Filler SG, Yeaman MR, Ibrahim AS. The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection. PLoS Pathog. 2018 05; 14(5):e1007056. PMID: 29746596.
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    16. Yeaman MR, Büttner S, Thevissen K. Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics. Oxid Med Cell Longev. 2018; 2018:5473817. PMID: 29854086.
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    17. Dillen CA, Pinsker BL, Marusina AI, Merleev AA, Farber ON, Liu H, Archer NK, Lee DB, Wang Y, Ortines RV, Lee SK, Marchitto MC, Cai SS, Ashbaugh AG, May LS, Holland SM, Freeman AF, Miller LG, Yeaman MR, Simon SI, Milner JD, Maverakis E, Miller LS. Clonally expanded ?d T cells protect against Staphylococcus aureus skin reinfection. J Clin Invest. 2018 03 01; 128(3):1026-1042. PMID: 29400698.
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    18. Chan LC, Chaili S, Filler SG, Miller LS, Solis NV, Wang H, Johnson CW, Lee HK, Diaz LF, Yeaman MR. Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus. Infect Immun. 2017 02; 85(2). PMID: 27849182.
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    19. Yeaman MR, Hennessey JP. Innovative Approaches to Improve Anti-Infective Vaccine Efficacy. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:189-222. PMID: 28061685.
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    20. Bar-Or A, Steinman L, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Smith TJ, Yeaman MR. Restoring immune tolerance in neuromyelitis optica: Part II. Neurol Neuroimmunol Neuroinflamm. 2016 Oct; 3(5):e277. PMID: 27648464.
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    21. Steinman L, Bar-Or A, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Yeaman MR, Smith TJ. Restoring immune tolerance in neuromyelitis optica: Part I. Neurol Neuroimmunol Neuroinflamm. 2016 Oct; 3(5):e276. PMID: 27648463.
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    22. Li L, Cheung A, Bayer AS, Chen L, Abdelhady W, Kreiswirth BN, Yeaman MR, Xiong YQ. The Global Regulon sarA Regulates ß-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections. J Infect Dis. 2016 Nov 01; 214(9):1421-1429. PMID: 27543672.
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    23. Khatib TO, Stevenson H, Yeaman MR, Bayer AS, Pokorny A. Binding of Daptomycin to Anionic Lipid Vesicles Is Reduced in the Presence of Lysyl-Phosphatidylglycerol. Antimicrob Agents Chemother. 2016 08; 60(8):5051-3. PMID: 27216066.
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    24. Chaili S, Cheung AL, Bayer AS, Xiong YQ, Waring AJ, Memmi G, Donegan N, Yang SJ, Yeaman MR. The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action. Infect Immun. 2016 02; 84(2):459-66. PMID: 26597988.
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    25. Chan LC, Chaili S, Filler SG, Barr K, Wang H, Kupferwasser D, Edwards JE, Xiong YQ, Ibrahim AS, Miller LS, Schmidt CS, Hennessey JP, Yeaman MR. Nonredundant Roles of Interleukin-17A (IL-17A) and IL-22 in Murine Host Defense against Cutaneous and Hematogenous Infection Due to Methicillin-Resistant Staphylococcus aureus. Infect Immun. 2015 Nov; 83(11):4427-37. PMID: 26351278.
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    26. Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, Würfel J, Zamvil S. Update on biomarkers in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm. 2015 Aug; 2(4):e134. PMID: 26236760.
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    27. Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, Villoslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul F, Kim HJ, de Seze J, Wuerfel JT, Cabre P, Marignier R, Tedder T, van Pelt D, Broadley S, Chitnis T, Wingerchuk D, Pandit L, Leite MI, Apiwattanakul M, Kleiter I, Prayoonwiwat N, Han M, Hellwig K, van Herle K, John G, Hooper DC, Nakashima I, Sato D, Yeaman MR, Waubant E, Zamvil S, Stüve O, Aktas O, Smith TJ, Jacob A, O'Connor K. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder. JAMA Neurol. 2015 Jul; 72(7):815-22. PMID: 26010909.
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    28. Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C. B lymphocytes in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2(3):e104. PMID: 25977932.
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    29. Weinshenker BG, Barron G, Behne JM, Bennett JL, Chin PS, Cree BA, de Seze J, Flor A, Fujihara K, Greenberg B, Higashi S, Holt W, Khan O, Knappertz V, Levy M, Melia AT, Palace J, Smith TJ, Sormani MP, Van Herle K, VanMeter S, Villoslada P, Walton MK, Wasiewski W, Wingerchuk DM, Yeaman MR. Challenges and opportunities in designing clinical trials for neuromyelitis optica. Neurology. 2015 Apr 28; 84(17):1805-15. PMID: 25841026.
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    30. Abdelhady W, Chen L, Bayer AS, Seidl K, Yeaman MR, Kreiswirth BN, Xiong YQ. Early agr activation correlates with vancomycin treatment failure in multi-clonotype MRSA endovascular infections. J Antimicrob Chemother. 2015 May; 70(5):1443-52. PMID: 25564565.
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    31. Yeaman MR, Filler SG, Chaili S, Barr K, Wang H, Kupferwasser D, Hennessey JP, Fu Y, Schmidt CS, Edwards JE, Xiong YQ, Ibrahim AS. Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5555-63. PMID: 25489065.
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    32. Reyes J, Panesso D, Tran TT, Mishra NN, Cruz MR, Munita JM, Singh KV, Yeaman MR, Murray BE, Shamoo Y, Garsin D, Bayer AS, Arias CA. A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis. J Infect Dis. 2015 Apr 15; 211(8):1317-25. PMID: 25362197.
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    33. Bayer AS, Mishra NN, Sakoulas G, Nonejuie P, Nast CC, Pogliano J, Chen KT, Ellison SN, Yeaman MR, Yang SJ. Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides. Antimicrob Agents Chemother. 2014 Dec; 58(12):7462-7. PMID: 25288091.
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    34. Cheung AL, Bayer AS, Yeaman MR, Xiong YQ, Waring AJ, Memmi G, Donegan N, Chaili S, Yang SJ. Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides. Infect Immun. 2014 Dec; 82(12):5336-45. PMID: 25287929.
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    35. Yeaman MR, Filler SG, Schmidt CS, Ibrahim AS, Edwards JE, Hennessey JP. Applying Convergent Immunity to Innovative Vaccines Targeting Staphylococcus aureus. Front Immunol. 2014; 5:463. PMID: 25309545.
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    36. Mishra NN, Bayer AS, Weidenmaier C, Grau T, Wanner S, Stefani S, Cafiso V, Bertuccio T, Yeaman MR, Nast CC, Yang SJ. Phenotypic and genotypic characterization of daptomycin-resistant methicillin-resistant Staphylococcus aureus strains: relative roles of mprF and dlt operons. PLoS One. 2014; 9(9):e107426. PMID: 25226591.
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    37. Yeaman MR. Platelets: at the nexus of antimicrobial defence. Nat Rev Microbiol. 2014 Jun; 12(6):426-37. PMID: 24830471.
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    38. Abdelhady W, Bayer AS, Seidl K, Moormeier DE, Bayles KW, Cheung A, Yeaman MR, Xiong YQ. Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 2014 Apr 15; 209(8):1231-40. PMID: 24403556.
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    39. Gebremariam T, Liu M, Luo G, Bruno V, Phan QT, Waring AJ, Edwards JE, Filler SG, Yeaman MR, Ibrahim AS. CotH3 mediates fungal invasion of host cells during mucormycosis. J Clin Invest. 2014 Jan; 124(1):237-50. PMID: 24355926.
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    40. Sakoulas G, Okumura CY, Thienphrapa W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman MR, Hensler ME, Bayer AS, Nizet V. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl). 2014 Feb; 92(2):139-49. PMID: 24297496.
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    41. Ibrahim AS, Luo G, Gebremariam T, Lee H, Schmidt CS, Hennessey JP, French SW, Yeaman MR, Filler SG, Edwards JE. NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response. Vaccine. 2013 Nov 12; 31(47):5549-56. PMID: 24063977.
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    42. Mishra NN, Yang SJ, Chen L, Muller C, Saleh-Mghir A, Kuhn S, Peschel A, Yeaman MR, Nast CC, Kreiswirth BN, Crémieux AC, Bayer AS. Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms. PLoS One. 2013; 8(8):e71151. PMID: 23990934.
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    43. Yang SJ, Xiong YQ, Yeaman MR, Bayles KW, Abdelhady W, Bayer AS. Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Aug; 57(8):3875-82. PMID: 23733465.
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    44. Jung SI, Finkel JS, Solis NV, Chaili S, Mitchell AP, Yeaman MR, Filler SG. Bcr1 functions downstream of Ssd1 to mediate antimicrobial peptide resistance in Candida albicans. Eukaryot Cell. 2013 Mar; 12(3):411-9. PMID: 23314964.
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    45. Yount NY, Yeaman MR. Peptide antimicrobials: cell wall as a bacterial target. Ann N Y Acad Sci. 2013 Jan; 1277:127-38. PMID: 23302022.
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    46. Abdelhady W, Bayer AS, Seidl K, Nast CC, Kiedrowski MR, Horswill AR, Yeaman MR, Xiong YQ. Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Mar; 57(3):1447-54. PMID: 23295925.
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    47. Gao W, Cameron DR, Davies JK, Kostoulias X, Stepnell J, Tuck KL, Yeaman MR, Peleg AY, Stinear TP, Howden BP. The RpoB H481Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus. J Infect Dis. 2013 Mar 15; 207(6):929-39. PMID: 23255563.
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    48. Schmidt CS, White CJ, Ibrahim AS, Filler SG, Fu Y, Yeaman MR, Edwards JE, Hennessey JP. NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults. Vaccine. 2012 Dec 14; 30(52):7594-600. PMID: 23099329.
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    49. Mishra NN, Bayer AS, Moise PA, Yeaman MR, Sakoulas G. Reduced susceptibility to host-defense cationic peptides and daptomycin coemerge in methicillin-resistant Staphylococcus aureus from daptomycin-naive bacteremic patients. J Infect Dis. 2012 Oct; 206(8):1160-7. PMID: 22904338.
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    50. Yount NY, Yeaman MR. Emerging themes and therapeutic prospects for anti-infective peptides. Annu Rev Pharmacol Toxicol. 2012; 52:337-60. PMID: 22235859.
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    51. Van Herle K, Behne JM, Van Herle A, Blaschke TF, Smith TJ, Yeaman MR. Integrative continuum: accelerating therapeutic advances in rare autoimmune diseases. Annu Rev Pharmacol Toxicol. 2012; 52:523-47. PMID: 22235861.
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    52. Sakoulas G, Bayer AS, Pogliano J, Tsuji BT, Yang SJ, Mishra NN, Nizet V, Yeaman MR, Moise PA. Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2012 Feb; 56(2):838-44. PMID: 22123698.
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    53. Erfe MC, David CV, Huang C, Lu V, Maretti-Mira AC, Haskell J, Bruhn KW, Yeaman MR, Craft N. Efficacy of synthetic peptides RP-1 and AA-RP-1 against Leishmania species in vitro and in vivo. Antimicrob Agents Chemother. 2012 Feb; 56(2):658-65. PMID: 22123683.
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    54. Yount NY, Cohen SE, Kupferwasser D, Waring AJ, Ruchala P, Sharma S, Wasserman K, Jung CL, Yeaman MR. Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1. PLoS One. 2011; 6(11):e26727. PMID: 22073187.
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    55. Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL. The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides. Infect Immun. 2012 Jan; 80(1):74-81. PMID: 21986630.
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    56. Xiong YQ, Hady WA, Deslandes A, Rey A, Fraisse L, Kristensen HH, Yeaman MR, Bayer AS. Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Nov; 55(11):5325-30. PMID: 21859940.
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    57. Mishra NN, McKinnell J, Yeaman MR, Rubio A, Nast CC, Chen L, Kreiswirth BN, Bayer AS. In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011 Sep; 55(9):4012-8. PMID: 21709105.
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    58. Fischer A, Yang SJ, Bayer AS, Vaezzadeh AR, Herzig S, Stenz L, Girard M, Sakoulas G, Scherl A, Yeaman MR, Proctor RA, Schrenzel J, François P. Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approach. J Antimicrob Chemother. 2011 Aug; 66(8):1696-711. PMID: 21622973.
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    59. Bertsche U, Weidenmaier C, Kuehner D, Yang SJ, Baur S, Wanner S, Francois P, Schrenzel J, Yeaman MR, Bayer AS. Correlation of daptomycin resistance in a clinical Staphylococcus aureus strain with increased cell wall teichoic acid production and D-alanylation. Antimicrob Agents Chemother. 2011 Aug; 55(8):3922-8. PMID: 21606222.
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    60. Mishra NN, Liu GY, Yeaman MR, Nast CC, Proctor RA, McKinnell J, Bayer AS. Carotenoid-related alteration of cell membrane fluidity impacts Staphylococcus aureus susceptibility to host defense peptides. Antimicrob Agents Chemother. 2011 Feb; 55(2):526-31. PMID: 21115796.
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    61. Seidl K, Bayer AS, Fowler VG, McKinnell JA, Abdel Hady W, Sakoulas G, Yeaman MR, Xiong YQ. Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates. Antimicrob Agents Chemother. 2011 Feb; 55(2):575-82. PMID: 21098242.
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    62. Kilelee E, Pokorny A, Yeaman MR, Bayer AS. Lysyl-phosphatidylglycerol attenuates membrane perturbation rather than surface association of the cationic antimicrobial peptide 6W-RP-1 in a model membrane system: implications for daptomycin resistance. Antimicrob Agents Chemother. 2010 Oct; 54(10):4476-9. PMID: 20660664.
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    63. Yang SJ, Nast CC, Mishra NN, Yeaman MR, Fey PD, Bayer AS. Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. Antimicrob Agents Chemother. 2010 Aug; 54(8):3079-85. PMID: 20498310.
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    64. Yeaman MR. Bacterial-platelet interactions: virulence meets host defense. Future Microbiol. 2010 Mar; 5(3):471-506. PMID: 20210555.
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    65. Moise PA, Forrest A, Bayer AS, Xiong YQ, Yeaman MR, Sakoulas G. Factors influencing time to vancomycin-induced clearance of nonendocarditis methicillin-resistant Staphylococcus aureus bacteremia: role of platelet microbicidal protein killing and agr genotypes. J Infect Dis. 2010 Jan 15; 201(2):233-40. PMID: 20001853.
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    66. Yeaman MR. Platelets in defense against bacterial pathogens. Cell Mol Life Sci. 2010 Feb; 67(4):525-44. PMID: 20013024.
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    67. Yang SJ, Kreiswirth BN, Sakoulas G, Yeaman MR, Xiong YQ, Sawa A, Bayer AS. Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureus. J Infect Dis. 2009 Dec 15; 200(12):1916-20. PMID: 19919306.
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    68. Bourbigot S, Fardy L, Waring AJ, Yeaman MR, Booth V. Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers. Biochemistry. 2009 Nov 10; 48(44):10509-21. PMID: 19813761.
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    69. Park H, Liu Y, Solis N, Spotkov J, Hamaker J, Blankenship JR, Yeaman MR, Mitchell AP, Liu H, Filler SG. Transcriptional responses of candida albicans to epithelial and endothelial cells. Eukaryot Cell. 2009 Oct; 8(10):1498-510. PMID: 19700637.
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    70. Yount NY, Kupferwasser D, Spisni A, Dutz SM, Ramjan ZH, Sharma S, Waring AJ, Yeaman MR. Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14972-7. PMID: 19706485.
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    71. Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS. Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009 Jun; 53(6):2312-8. PMID: 19332678.
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    72. Xiong YQ, Fowler VG, Yeaman MR, Perdreau-Remington F, Kreiswirth BN, Bayer AS. Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis model. J Infect Dis. 2009 Jan 15; 199(2):201-8. PMID: 19086913.
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    73. Bourbigot S, Dodd E, Horwood C, Cumby N, Fardy L, Welch WH, Ramjan Z, Sharma S, Waring AJ, Yeaman MR, Booth V. Antimicrobial peptide RP-1 structure and interactions with anionic versus zwitterionic micelles. Biopolymers. 2009 Jan; 91(1):1-13. PMID: 18712851.
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    74. Trier DA, Gank KD, Kupferwasser D, Yount NY, French WJ, Michelson AD, Kupferwasser LI, Xiong YQ, Bayer AS, Yeaman MR. Platelet antistaphylococcal responses occur through P2X1 and P2Y12 receptor-induced activation and kinocidin release. Infect Immun. 2008 Dec; 76(12):5706-13. PMID: 18824536.
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    75. Spellberg B, Ibrahim AS, Yeaman MR, Lin L, Fu Y, Avanesian V, Bayer AS, Filler SG, Lipke P, Otoo H, Edwards JE. The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus. Infect Immun. 2008 Oct; 76(10):4574-80. PMID: 18644876.
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    76. Gank KD, Yeaman MR, Kojima S, Yount NY, Park H, Edwards JE, Filler SG, Fu Y. SSD1 is integral to host defense peptide resistance in Candida albicans. Eukaryot Cell. 2008 Aug; 7(8):1318-27. PMID: 18515753.
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    77. Jones T, Yeaman MR, Sakoulas G, Yang SJ, Proctor RA, Sahl HG, Schrenzel J, Xiong YQ, Bayer AS. Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding. Antimicrob Agents Chemother. 2008 Jan; 52(1):269-78. PMID: 17954690.
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    78. Rieg G, Yeaman M, Lail AE, Donfield SM, Gomperts ED, Daar ES. Platelet count is associated with plasma HIV type 1 RNA and disease progression. AIDS Res Hum Retroviruses. 2007 Oct; 23(10):1257-61. PMID: 17961113.
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    79. Yeaman MR, Yount NY. Unifying themes in host defence effector polypeptides. Nat Rev Microbiol. 2007 Sep; 5(9):727-40. PMID: 17703227.
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    80. Yount NY, Andrés MT, Fierro JF, Yeaman MR. The gamma-core motif correlates with antimicrobial activity in cysteine-containing kaliocin-1 originating from transferrins. Biochim Biophys Acta. 2007 Nov; 1768(11):2862-72. PMID: 17916323.
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    81. Mukhopadhyay K, Whitmire W, Xiong YQ, Molden J, Jones T, Peschel A, Staubitz P, Adler-Moore J, McNamara PJ, Proctor RA, Yeaman MR, Bayer AS. In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetry. Microbiology. 2007 Apr; 153(Pt 4):1187-97. PMID: 17379728.
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    82. Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, Welch WH, Ibrahim AS, Edwards JE, Filler SG. Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biol. 2007 Mar; 5(3):e64. PMID: 17311474.
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    83. Yeaman MR, Yount NY, Waring AJ, Gank KD, Kupferwasser D, Wiese R, Bayer AS, Welch WH. Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins. Biochim Biophys Acta. 2007 Mar; 1768(3):609-19. PMID: 17217910.
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    84. Yount NY, Waring AJ, Gank KD, Welch WH, Kupferwasser D, Yeaman MR. Structural correlates of antimicrobial efficacy in IL-8 and related human kinocidins. Biochim Biophys Acta. 2007 Mar; 1768(3):598-608. PMID: 17208195.
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    85. Xiong YQ, Willard J, Yeaman MR, Cheung AL, Bayer AS. Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis. J Infect Dis. 2006 Nov 01; 194(9):1267-75. PMID: 17041853.
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    86. Xiong YQ, Bayer AS, Elazegui L, Yeaman MR. A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule. Antimicrob Agents Chemother. 2006 Nov; 50(11):3786-92. PMID: 16954324.
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    87. Palma M, Bayer A, Kupferwasser LI, Joska T, Yeaman MR, Cheung A. Salicylic acid activates sigma factor B by rsbU-dependent and -independent mechanisms. J Bacteriol. 2006 Aug; 188(16):5896-903. PMID: 16885458.
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    88. Spellberg BJ, Ibrahim AS, Avanesian V, Fu Y, Myers C, Phan QT, Filler SG, Yeaman MR, Edwards JE. Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis. J Infect Dis. 2006 Jul 15; 194(2):256-60. PMID: 16779733.
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    89. Yount NY, Yeaman MR. Structural congruence among membrane-active host defense polypeptides of diverse phylogeny. Biochim Biophys Acta. 2006 Sep; 1758(9):1373-86. PMID: 16725105.
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    90. Yount NY, Bayer AS, Xiong YQ, Yeaman MR. Advances in antimicrobial peptide immunobiology. Biopolymers. 2006; 84(5):435-58. PMID: 16736494.
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    91. Bayer AS, McNamara P, Yeaman MR, Lucindo N, Jones T, Cheung AL, Sahl HG, Proctor RA. Transposon disruption of the complex I NADH oxidoreductase gene (snoD) in Staphylococcus aureus is associated with reduced susceptibility to the microbicidal activity of thrombin-induced platelet microbicidal protein 1. J Bacteriol. 2006 Jan; 188(1):211-22. PMID: 16352837.
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    92. Yeaman MR, Bayer AS. Antimicrobial peptides versus invasive infections. Curr Top Microbiol Immunol. 2006; 306:111-52. PMID: 16909920.
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    93. Weidenmaier C, Peschel A, Kempf VA, Lucindo N, Yeaman MR, Bayer AS. DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model. Infect Immun. 2005 Dec; 73(12):8033-8. PMID: 16299297.
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    94. Filler SG, Yeaman MR, Sheppard DC. Tumor necrosis factor inhibition and invasive fungal infections. Clin Infect Dis. 2005 Aug 01; 41 Suppl 3:S208-12. PMID: 15983902.
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    95. Xiong YQ, Mukhopadhyay K, Yeaman MR, Adler-Moore J, Bayer AS. Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Aug; 49(8):3114-21. PMID: 16048912.
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    96. Sakoulas G, Eliopoulos GM, Fowler VG, Moellering RC, Novick RP, Lucindo N, Yeaman MR, Bayer AS. Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function. Antimicrob Agents Chemother. 2005 Jul; 49(7):2687-92. PMID: 15980337.
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    97. Weidenmaier C, Peschel A, Xiong YQ, Kristian SA, Dietz K, Yeaman MR, Bayer AS. Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis. J Infect Dis. 2005 May 15; 191(10):1771-7. PMID: 15838806.
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    98. Yount NY, Yeaman MR. Immunocontinuum: perspectives in antimicrobial peptide mechanisms of action and resistance. Protein Pept Lett. 2005 Jan; 12(1):49-67. PMID: 15638803.
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    99. Yount NY, Gank KD, Xiong YQ, Bayer AS, Pender T, Welch WH, Yeaman MR. Platelet microbicidal protein 1: structural themes of a multifunctional antimicrobial peptide. Antimicrob Agents Chemother. 2004 Nov; 48(11):4395-404. PMID: 15504869.
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    100. Fowler VG, Sakoulas G, McIntyre LM, Meka VG, Arbeit RD, Cabell CH, Stryjewski ME, Eliopoulos GM, Reller LB, Corey GR, Jones T, Lucindo N, Yeaman MR, Bayer AS. Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. J Infect Dis. 2004 Sep 15; 190(6):1140-9. PMID: 15319865.
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    101. Yeaman MR, Cheng D, Desai B, Kupferwasser LI, Xiong YQ, Gank KD, Edwards JE, Bayer AS. Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans. Antimicrob Agents Chemother. 2004 Aug; 48(8):3051-6. PMID: 15273120.
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    102. Mercier RC, Dietz RM, Mazzola JL, Bayer AS, Yeaman MR. Beneficial influence of platelets on antibiotic efficacy in an in vitro model of Staphylococcus aureus-induced endocarditis. Antimicrob Agents Chemother. 2004 Jul; 48(7):2551-7. PMID: 15215108.
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    103. Sheppard DC, Yeaman MR, Welch WH, Phan QT, Fu Y, Ibrahim AS, Filler SG, Zhang M, Waring AJ, Edwards JE. Functional and structural diversity in the Als protein family of Candida albicans. J Biol Chem. 2004 Jul 16; 279(29):30480-9. PMID: 15128742.
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    104. Yount NY, Yeaman MR. Multidimensional signatures in antimicrobial peptides. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7363-8. PMID: 15118082.
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    105. Xiong YQ, Bayer AS, Yeaman MR, Van Wamel W, Manna AC, Cheung AL. Impacts of sarA and agr in Staphylococcus aureus strain Newman on fibronectin-binding protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditis. Infect Immun. 2004 Mar; 72(3):1832-6. PMID: 14977998.
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    106. Kupferwasser LI, Yeaman MR, Nast CC, Kupferwasser D, Xiong YQ, Palma M, Cheung AL, Bayer AS. Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus. J Clin Invest. 2003 Jul; 112(2):222-33. PMID: 12865410.
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    107. Bates DM, von Eiff C, McNamara PJ, Peters G, Yeaman MR, Bayer AS, Proctor RA. Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney. J Infect Dis. 2003 May 15; 187(10):1654-61. PMID: 12721946.
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    108. Yeaman MR, Yount NY. Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev. 2003 Mar; 55(1):27-55. PMID: 12615953.
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    109. Yeaman MR, Gank KD, Bayer AS, Brass EP. Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matrices. Antimicrob Agents Chemother. 2002 Dec; 46(12):3883-91. PMID: 12435692.
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    110. Tang YQ, Yeaman MR, Selsted ME. Antimicrobial peptides from human platelets. Infect Immun. 2002 Dec; 70(12):6524-33. PMID: 12438321.
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    111. Xiong YQ, Van Wamel W, Nast CC, Yeaman MR, Cheung AL, Bayer AS. Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aureus in vitro and in an experimental endocarditis model. J Infect Dis. 2002 Sep 01; 186(5):668-77. PMID: 12195354.
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    112. van Wamel W, Xiong YQ, Bayer AS, Yeaman MR, Nast CC, Cheung AL. Regulation of Staphylococcus aureus type 5 capsular polysaccharides by agr and sarA in vitro and in an experimental endocarditis model. Microb Pathog. 2002 Aug; 33(2):73-9. PMID: 12202106.
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    113. Kupferwasser LI, Yeaman MR, Shapiro SM, Nast CC, Bayer AS. In vitro susceptibility to thrombin-induced platelet microbicidal protein is associated with reduced disease progression and complication rates in experimental Staphylococcus aureus endocarditis: microbiological, histopathologic, and echocardiographic analyses. Circulation. 2002 Feb 12; 105(6):746-52. PMID: 11839632.
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    114. Xiong YQ, Bayer AS, Yeaman MR. Inhibition of intracellular macromolecular synthesis in Staphylococcus aureus by thrombin-induced platelet microbicidal proteins. J Infect Dis. 2002 Feb 01; 185(3):348-56. PMID: 11807717.
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    115. Yeaman MR, Bayer AS. Antimicrobial peptides from platelets. Drug Resist Updat. 1999 Apr; 2(2):116-126. PMID: 11504479.
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