Patricia J Johnson

Title(s)Professor, MIMG
SchoolMedicine
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    Identification of key players mediating internalization of Trichomonas vaginalis extracellular vesicles by host cells and parasite adherence and survival in vivo
    NIH R01AI148475Jun 2, 2020 - May 31, 2025
    Role: Principal Investigator
    Mechanisms of neutrophil killing of the human-infective parasite Trichomonas vaginalis and immune evasion by the parasite and its symbiont Mycoplasma hominis
    NIH R21AI142525Jan 9, 2019 - Dec 31, 2021
    Role: Principal Investigator
    Inhibitors of Nitro Drug Targets as Antimicrobials against Trichomonas Vaginalis
    NIH R33AI119721Jun 15, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Inhibitors of Nitro Drug Targets as Antimicrobials against Trichomonas Vaginalis
    NIH R21AI119721Jun 15, 2015 - May 31, 2017
    Role: Principal Investigator
    Trichomonas vaginalis MIF: a role in prostate cancer and infertility?
    NIH R21AI105779Aug 8, 2013 - Jul 31, 2016
    Role: Principal Investigator
    Trichomonas vaginalis exosomes: Mediators of host:pathogen interactions
    NIH R01AI103182Jun 1, 2013 - May 31, 2019
    Role: Principal Investigator
    Role of tetraspanin proteins in Trichomonas vaginalis pathogenesis
    NIH R03TW009026Mar 8, 2013 - Feb 28, 2017
    Role: Principal Investigator
    2012 International Conference on Anaerobic Parasites (ICAP)
    NIH R13AI102494Jun 1, 2012 - May 31, 2013
    Role: Principal Investigator
    Trichomonas pathogenesis: cell surface interactions
    NIH R01AI069058Jul 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Gene Expression in Trichomonas vaginalis
    NIH R01AI030537Sep 1, 1991 - Jun 30, 2009
    Role: Principal Investigator
    Biogenesis of Hydrogenosomes of a Trichomonad Parasite
    NIH R37AI027857Apr 1, 1989 - Mar 31, 2015
    Role: Principal Investigator
    BIOGENESIS OF HYDROGENOSOMES OF A TRICHOMONAD PARASITE
    NIH R01AI027857Apr 1, 1989 - Mar 31, 2004
    Role: Principal Investigator
    BIOGENESIS OF HYDROGENOSOMES OF A TRICHOMONAD PARASITE
    NIH R29AI027857Apr 1, 1989 - Mar 31, 1994
    Role: Principal Investigator
    Multidisciplinary Training in Microbial Pathogenesis
    NIH T32AI007323Sep 1, 1988 - Jun 30, 2025
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2. mBio. 2021 03 30; 12(2). Stevens A, Muratore K, Cui Y, Johnson PJ, Zhou ZH. PMID: 33785622.
      View in: PubMed   Mentions:    Fields:    
    2. A Novel Trichomonas vaginalis Surface Protein Modulates Parasite Attachment via Protein:Host Cell Proteoglycan Interaction. mBio. 2021 02 09; 12(1). Molgora BM, Rai AK, Sweredoski MJ, Moradian A, Hess S, Johnson PJ. PMID: 33563826.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Trichomonas vaginalis extracellular vesicles are internalized by host cells using proteoglycans and caveolin-dependent endocytosis. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21354-21360. Rai AK, Johnson PJ. PMID: 31601738.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    4. A Novel Cadherin-like Protein Mediates Adherence to and Killing of Host Cells by the Parasite Trichomonas vaginalis. mBio. 2019 05 14; 10(3). Chen YP, Riestra AM, Rai AK, Johnson PJ. PMID: 31088924.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Trichomonas vaginalis Macrophage Migration Inhibitory Factor Mediates Parasite Survival during Nutrient Stress. mBio. 2018 06 26; 9(3). Chen YP, Twu O, Johnson PJ. PMID: 29946046.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence. Mol Cell Proteomics. 2018 11; 17(11):2229-2241. Nievas YR, Vashisht AA, Corvi MM, Metz S, Johnson PJ, Wohlschlegel JA, de Miguel N. PMID: 29444981.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Neutrophils kill the parasite Trichomonas vaginalis using trogocytosis. PLoS Biol. 2018 02; 16(2):e2003885. Mercer F, Ng SH, Brown TM, Boatman G, Johnson PJ. PMID: 29408891.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    8. CRISPR/Cas9-mediated gene modification and gene knock out in the human-infective parasite Trichomonas vaginalis. Sci Rep. 2018 01 10; 8(1):270. Janssen BD, Chen YP, Molgora BM, Wang SE, Simoes-Barbosa A, Johnson PJ. PMID: 29321601.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    9. Membrane-shed vesicles from the parasite Trichomonas vaginalis: characterization and their association with cell interaction. Cell Mol Life Sci. 2018 06; 75(12):2211-2226. Nievas YR, Coceres VM, Midlej V, de Souza W, Benchimol M, Pereira-Neves A, Vashisht AA, Wohlschlegel JA, Johnson PJ, de Miguel N. PMID: 29222644.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis. Cell Microbiol. 2017 06; 19(6). Pachano T, Nievas YR, Lizarraga A, Johnson PJ, Strobl-Mazzulla PH, de Miguel N. PMID: 28054438.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Leukocyte Lysis and Cytokine Induction by the Human Sexually Transmitted Parasite Trichomonas vaginalis. PLoS Negl Trop Dis. 2016 08; 10(8):e0004913. Mercer F, Diala FG, Chen YP, Molgora BM, Ng SH, Johnson PJ. PMID: 27529696.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    12. A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells. PLoS Pathog. 2015 Dec; 11(12):e1005294. Riestra AM, Gandhi S, Sweredoski MJ, Moradian A, Hess S, Urban S, Johnson PJ. PMID: 26684303.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Parasite extracellular vesicles: mediators of intercellular communication. PLoS Pathog. 2014 Aug; 10(8):e1004289. Twu O, Johnson PJ. PMID: 25166021.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8179-84. Twu O, Dessí D, Vu A, Mercer F, Stevens GC, de Miguel N, Rappelli P, Cocco AR, Clubb RT, Fiori PL, Johnson PJ. PMID: 24843155.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    15. A dynamin-related protein contributes to Trichomonas vaginalis hydrogenosomal fission. FASEB J. 2014 Mar; 28(3):1113-21. Wexler-Cohen Y, Stevens GC, Barnoy E, van der Bliek AM, Johnson PJ. PMID: 24297697.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Trichomonas vaginalis exosomes deliver cargo to host cells and mediate host∶parasite interactions. PLoS Pathog. 2013; 9(7):e1003482. Twu O, de Miguel N, Lustig G, Stevens GC, Vashisht AA, Wohlschlegel JA, Johnson PJ. PMID: 23853596.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    17. Trichomonas vaginalis contact-dependent cytolysis of epithelial cells. Infect Immun. 2013 May; 81(5):1411-9. Lustig G, Ryan CM, Secor WE, Johnson PJ. PMID: 23429535.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    18. Reversible association of tetraspanin with Trichomonas vaginalis flagella upon adherence to host cells. Cell Microbiol. 2012 Dec; 14(12):1797-807. de Miguel N, Riestra A, Johnson PJ. PMID: 22882837.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA. 2012 Sep; 18(9):1656-65. Simoes-Barbosa A, Chakrabarti K, Pearson M, Benarroch D, Shuman S, Johnson PJ. PMID: 22847815.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes. Int J Parasitol. 2011 Nov; 41(13-14):1421-34. Schneider RE, Brown MT, Shiflett AM, Dyall SD, Hayes RD, Xie Y, Loo JA, Johnson PJ. PMID: 22079833.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    21. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (β1-4/3) N-acetylglucosamine repeats in host cell interaction. J Biol Chem. 2011 Nov 25; 286(47):40494-508. Ryan CM, Mehlert A, Richardson JM, Ferguson MA, Johnson PJ. PMID: 21900246.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Novel core promoter elements and a cognate transcription factor in the divergent unicellular eukaryote Trichomonas vaginalis. Mol Cell Biol. 2011 Apr; 31(7):1444-58. Smith AJ, Chudnovsky L, Simoes-Barbosa A, Delgadillo-Correa MG, Jonsson ZO, Wohlschlegel JA, Johnson PJ. PMID: 21245378.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. Trichomonas vaginalis: current understanding of host-parasite interactions. Essays Biochem. 2011; 51:161-75. Ryan CM, de Miguel N, Johnson PJ. PMID: 22023448.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    24. A metazoan/plant-like capping enzyme and cap modified nucleotides in the unicellular eukaryote Trichomonas vaginalis. PLoS Pathog. 2010 Jul 15; 6(7):e1000999. Simoes-Barbosa A, Hirt RP, Johnson PJ. PMID: 20664792.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    25. Proteome analysis of the surface of Trichomonas vaginalis reveals novel proteins and strain-dependent differential expression. Mol Cell Proteomics. 2010 Jul; 9(7):1554-66. de Miguel N, Lustig G, Twu O, Chattopadhyay A, Wohlschlegel JA, Johnson PJ. PMID: 20467041.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    26. Mitochondrion-related organelles in eukaryotic protists. Annu Rev Microbiol. 2010; 64:409-29. Shiflett AM, Johnson PJ. PMID: 20528687.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    27. The divergent eukaryote Trichomonas vaginalis has an m7G cap methyltransferase capable of a single N2 methylation. Nucleic Acids Res. 2008 Dec; 36(21):6848-58. Simoes-Barbosa A, Louly C, Franco OL, Rubio MA, Alfonzo JD, Johnson PJ. PMID: 18957443.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    28. Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis. Cell Microbiol. 2008 Oct; 10(10):2078-90. Okumura CY, Baum LG, Johnson PJ. PMID: 18637021.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    29. Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5'-cap structure. RNA. 2008 Aug; 14(8):1617-31. Simoes-Barbosa A, Meloni D, Wohlschlegel JA, Konarska MM, Johnson PJ. PMID: 18596255.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. A functionally divergent hydrogenosomal peptidase with protomitochondrial ancestry. Mol Microbiol. 2007 Jun; 64(5):1154-63. Brown MT, Goldstone HM, Bastida-Corcuera F, Delgadillo-Correa MG, McArthur AG, Johnson PJ. PMID: 17542912.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12; 315(5809):207-12. Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR, Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Müller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ. PMID: 17218520.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimalsCells
    32. Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell. 2006 Dec; 5(12):2062-71. Mukherjee M, Brown MT, McArthur AG, Johnson PJ. PMID: 17158739.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell. 2006 Dec; 5(12):2072-8. Mukherjee M, Sievers SA, Brown MT, Johnson PJ. PMID: 16980404.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    34. Trichomonas vaginalis initiator binding protein (IBP39) and RNA polymerase II large subunit carboxy terminal domain interaction. Mol Biochem Parasitol. 2006 Nov; 150(1):56-62. Lau AO, Smith AJ, Brown MT, Johnson PJ. PMID: 16879883.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. Trichomonas vaginalis lipophosphoglycan mutants have reduced adherence and cytotoxicity to human ectocervical cells. Eukaryot Cell. 2005 Nov; 4(11):1951-8. Bastida-Corcuera FD, Okumura CY, Colocoussi A, Johnson PJ. PMID: 16278462.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    36. Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4430-5. Vanácová S, Yan W, Carlton JM, Johnson PJ. PMID: 15764705.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    37. Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex. Nature. 2004 Oct 28; 431(7012):1103-7. Dyall SD, Yan W, Delgadillo-Correa MG, Lunceford A, Loo JA, Clarke CF, Johnson PJ. PMID: 15510149.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    38. A potentially functional mariner transposable element in the protist Trichomonas vaginalis. Mol Biol Evol. 2005 Jan; 22(1):126-34. Silva JC, Bastida F, Bidwell SL, Johnson PJ, Carlton JM. PMID: 15371525.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    39. Mitochondrial-type assembly of FeS centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10368-73. Sutak R, Dolezal P, Fiumera HL, Hrdy I, Dancis A, Delgadillo-Correa M, Johnson PJ, Müller M, Tachezy J. PMID: 15226492.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    40. Ancient invasions: from endosymbionts to organelles. Science. 2004 Apr 09; 304(5668):253-7. Dyall SD, Brown MT, Johnson PJ. PMID: 15073369.
      View in: PubMed   Mentions: 207     Fields:    Translation:Cells
    41. Ellobiopsids of the genus Thalassomyces are alveolates. J Eukaryot Microbiol. 2004 Mar-Apr; 51(2):246-52. Silberman JD, Collins AG, Gershwin LA, Johnson PJ, Roger AJ. PMID: 15134262.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    42. Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance. Mol Microbiol. 2004 Jan; 51(1):115-22. Land KM, Delgadillo-Correa MG, Tachezy J, Vanacova S, Hsieh CL, Sutak R, Johnson PJ. PMID: 14651615.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    43. Trichomonas vaginalis initiator binding protein, IBP39, contains a novel DNA binding motif. Mol Biochem Parasitol. 2003 Aug 31; 130(2):167-71. Lau AO, Liston DR, Vanacova S, Johnson PJ. PMID: 12946857.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    44. Trichomonas vaginalis Hmp35, a putative pore-forming hydrogenosomal membrane protein, can form a complex in yeast mitochondria. J Biol Chem. 2003 Aug 15; 278(33):30548-61. Dyall SD, Lester DC, Schneider RE, Delgadillo-Correa MG, Plümper E, Martinez A, Koehler CM, Johnson PJ. PMID: 12766161.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. Tetracycline-inducible gene expression in Trichomonas vaginalis. Mol Biochem Parasitol. 2003 Apr 25; 128(1):43-9. Ortiz D, Johnson PJ. PMID: 12706795.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    46. Molecular biology of the amitochondriate parasites, Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Int J Parasitol. 2003 Mar; 33(3):235-55. Vanacova S, Liston DR, Tachezy J, Johnson PJ. PMID: 12670510.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    47. Retortamonad flagellates are closely related to diplomonads--implications for the history of mitochondrial function in eukaryote evolution. Mol Biol Evol. 2002 May; 19(5):777-86. Silberman JD, Simpson AG, Kulda J, Cepicka I, Hampl V, Johnson PJ, Roger AJ. PMID: 11961110.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    48. In vivo expression of ferredoxin in a drug resistant trichomonad increases metronidazole susceptibility. Mol Biochem Parasitol. 2002 Apr 30; 121(1):153-7. Land KM, Delgadillo MG, Johnson PJ. PMID: 11985873.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    49. Spliceosomal introns in a deep-branching eukaryote: the splice of life. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3359-61. Johnson PJ. PMID: 11904397.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Molecular basis of metronidazole resistance in pathogenic bacteria and protozoa. Drug Resist Updat. 1999 Oct; 2(5):289-294. Land KM, Johnson PJ. PMID: 11504503.
      View in: PubMed   Mentions: 25     Fields:    
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