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Micevych, Paul E

Title(s)Professor, Neurobiology
Phone52123
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    Other Positions
    Title(s)Professor, Head and Neck Surgery


    Collapse Research 
    Collapse Research Activities and Funding
    Modulation of sex steroid-induced female social behaviors in an animal model
    NIH/NICHD R01HD098284Mar 5, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Physiology of hypothalamic neurosteroidal progesterone
    NIH/NICHD R01HD042635Apr 1, 2003 - May 31, 2014
    Role: Principal Investigator
    Sex Steroid Activation of Opioid Circuits in the CNS
    NIH/NIDA R01DA013185Mar 1, 2001 - Mar 31, 2011
    Role: Principal Investigator
    NEUROPEPTIDE-STEROID INTERACTIONS IN THE CNS
    NIH/NINDS R01NS039495Dec 10, 1999 - Nov 30, 2003
    Role: Principal Investigator
    ANDROGEN-INDUCED PLASTICITY IN ADULT SPINAL CORD
    NIH/NINDS R01NS023468Apr 1, 1986 - Mar 31, 1989
    Role: Principal Investigator
    DIFFERENCES IN CCK RELEASE AND FUNCTIONS
    NIH/NINDS R01NS021220Jul 1, 1984 - Mar 31, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Johnson C, Hong W, Micevych P. Optogenetic Activation of ß-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity. eNeuro. 2020 Jan/Feb; 7(1). PMID: 31941660.
      View in: PubMed
    2. Wong AM, Scott AK, Johnson CS, Mohr MA, Mittelman-Smith M, Micevych PE. ERa?4, an ERa splice variant missing exon4, interacts with caveolin-3 and mGluR2/3. J Neuroendocrinol. 2019 Jun; 31(6):e12725. PMID: 31050077.
      View in: PubMed
    3. Chen PB, Hu RK, Wu YE, Pan L, Huang S, Micevych PE, Hong W. Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala. Cell. 2019 02 21; 176(5):1206-1221.e18. PMID: 30773317.
      View in: PubMed
    4. Micevych PE, Sinchak K. Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity. Horm Behav. 2018 08; 104:4-14. PMID: 29753716.
      View in: PubMed
    5. Micevych PE, Mermelstein PG, Sinchak K. Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction. Trends Neurosci. 2017 11; 40(11):654-666. PMID: 28969926.
      View in: PubMed
    6. Micevych PE, Meisel RL. Integrating Neural Circuits Controlling Female Sexual Behavior. Front Syst Neurosci. 2017; 11:42. PMID: 28642689.
      View in: PubMed
    7. Mittelman-Smith MA, Wong AM, Micevych PE. Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin Neurons. Neuroendocrinology. 2018; 106(2):101-115. PMID: 28384629.
      View in: PubMed
    8. Rudolph LM, Cornil CA, Mittelman-Smith MA, Rainville JR, Remage-Healey L, Sinchak K, Micevych PE. Actions of Steroids: New Neurotransmitters. J Neurosci. 2016 11 09; 36(45):11449-11458. PMID: 27911748.
      View in: PubMed
    9. Micevych PE, Wong AM, Mittelman-Smith MA. Estradiol Membrane-Initiated Signaling and Female Reproduction. Compr Physiol. 2015 Jul 01; 5(3):1211-22. PMID: 26140715.
      View in: PubMed
    10. Wong AM, Abrams MC, Micevych PE. ß-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. PLoS One. 2015; 10(3):e0120530. PMID: 25803606.
      View in: PubMed
    11. Mittelman-Smith MA, Wong AM, Kathiresan AS, Micevych PE. Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons. Endocrinology. 2015 Jun; 156(6):2162-73. PMID: 25730107.
      View in: PubMed
    12. Chen C, Kuo J, Wong A, Micevych P. Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology. 2014 Aug; 155(8):2976-85. PMID: 24877623.
      View in: PubMed
    13. Sinchak K, Dewing P, Ponce L, Gomez L, Christensen A, Berger M, Micevych P. Modulation of the arcuate nucleus-medial preoptic nucleus lordosis regulating circuit: a role for GABAB receptors. Horm Behav. 2013 Jun; 64(1):136-43. PMID: 23756153.
      View in: PubMed
    14. Christensen A, Micevych P. A Novel Membrane Estrogen Receptor Activated by STX Induces Female Sexual Receptivity through an Interaction with mGluR1a. Neuroendocrinology. 2013; 97(4):363-8. PMID: 23571598.
      View in: PubMed
    15. Dominguez R, Dewing P, Kuo J, Micevych P. Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons. Steroids. 2013 Jun; 78(6):607-13. PMID: 23296142.
      View in: PubMed
    16. Micevych P. Membrane-initiated estradiol signaling regulates the central nervous system. Front Neuroendocrinol. 2012 Oct; 33(4):329-30. PMID: 23141474.
      View in: PubMed
    17. Micevych PE, Kelly MJ. Membrane estrogen receptor regulation of hypothalamic function. Neuroendocrinology. 2012; 96(2):103-10. PMID: 22538318.
      View in: PubMed
    18. Micevych P, Christensen A. Membrane-initiated estradiol actions mediate structural plasticity and reproduction. Front Neuroendocrinol. 2012 Oct; 33(4):331-41. PMID: 22828999.
      View in: PubMed
    19. Christensen A, Micevych P. CAV1 siRNA reduces membrane estrogen receptor-a levels and attenuates sexual receptivity. Endocrinology. 2012 Aug; 153(8):3872-7. PMID: 22669893.
      View in: PubMed
    20. Kuo J, Micevych P. Neurosteroids, trigger of the LH surge. J Steroid Biochem Mol Biol. 2012 Aug; 131(1-2):57-65. PMID: 22326732.
      View in: PubMed
    21. Micevych P, Sinchak K. The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge. Front Endocrinol (Lausanne). 2011; 2:90. PMID: 22654832.
      View in: PubMed
    22. Christensen A, Dewing P, Micevych P. Membrane-initiated estradiol signaling induces spinogenesis required for female sexual receptivity. J Neurosci. 2011 Nov 30; 31(48):17583-9. PMID: 22131419.
      View in: PubMed
    23. Micevych PE, Dewing P. Membrane-initiated estradiol signaling regulating sexual receptivity. Front Endocrinol (Lausanne). 2011; 2:26. PMID: 22649369.
      View in: PubMed
    24. Chaban V, Li J, McDonald JS, Rapkin A, Micevych P. Estradiol attenuates the adenosine triphosphate-induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat dorsal root ganglion neurons. J Neurosci Res. 2011 Nov; 89(11):1707-10. PMID: 21793040.
      View in: PubMed
    25. Kuo J, Hamid N, Bondar G, Dewing P, Clarkson J, Micevych P. Sex differences in hypothalamic astrocyte response to estradiol stimulation. Biol Sex Differ. 2010 Nov 22; 1(1):7. PMID: 21208471.
      View in: PubMed
    26. Kuo J, Hamid N, Bondar G, Prossnitz ER, Micevych P. Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. J Neurosci. 2010 Sep 29; 30(39):12950-7. PMID: 20881113.
      View in: PubMed
    27. Dominguez R, Micevych P. Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons. J Neurosci. 2010 Sep 22; 30(38):12589-96. PMID: 20861365.
      View in: PubMed
    28. Micevych P, Bondar G, Kuo J. Estrogen actions on neuroendocrine glia. Neuroendocrinology. 2010; 91(3):211-22. PMID: 20332598.
      View in: PubMed
    29. Bondar G, Kuo J, Hamid N, Micevych P. Estradiol-induced estrogen receptor-alpha trafficking. J Neurosci. 2009 Dec 02; 29(48):15323-30. PMID: 19955385.
      View in: PubMed
    30. Quesada A, Micevych P, Handforth A. C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1. Exp Neurol. 2009 Dec; 220(2):255-66. PMID: 19735655.
      View in: PubMed
    31. Micevych P, Dominguez R. Membrane estradiol signaling in the brain. Front Neuroendocrinol. 2009 Aug; 30(3):315-27. PMID: 19416735.
      View in: PubMed
    32. Micevych P, Kuo J, Christensen A. Physiology of membrane oestrogen receptor signalling in reproduction. J Neuroendocrinol. 2009 Mar; 21(4):249-56. PMID: 19207814.
      View in: PubMed
    33. Kuo J, Hariri OR, Bondar G, Ogi J, Micevych P. Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology. 2009 Mar; 150(3):1369-76. PMID: 18948402.
      View in: PubMed
    34. Li J, Micevych P, McDonald J, Rapkin A, Chaban V. Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res. 2008 Sep; 86(12):2746-52. PMID: 18478547.
      View in: PubMed
    35. Micevych PE, Mermelstein PG. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol. 2008 Aug; 38(1):66-77. PMID: 18670908.
      View in: PubMed
    36. Dewing P, Christensen A, Bondar G, Micevych P. Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats. Endocrinology. 2008 Dec; 149(12):5934-42. PMID: 18653714.
      View in: PubMed
    37. Micevych P, Sinchak K. Estradiol regulation of progesterone synthesis in the brain. Mol Cell Endocrinol. 2008 Aug 13; 290(1-2):44-50. PMID: 18572304.
      View in: PubMed
    38. Quesada A, Lee BY, Micevych PE. PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease. Dev Neurobiol. 2008 Apr; 68(5):632-44. PMID: 18278798.
      View in: PubMed
    39. Micevych P, Sinchak K. Synthesis and function of hypothalamic neuroprogesterone in reproduction. Endocrinology. 2008 Jun; 149(6):2739-42. PMID: 18308840.
      View in: PubMed
    40. Quesada A, Micevych P. Estrogen and progesterone modulate [35S]GTPgammaS binding to nociceptin receptors. Neuroendocrinology. 2008; 88(1):35-42. PMID: 18212517.
      View in: PubMed
    41. Mermelstein PG, Micevych PE. Nervous system physiology regulated by membrane estrogen receptors. Rev Neurosci. 2008; 19(6):413-24. PMID: 19317180.
      View in: PubMed
    42. Dewing P, Boulware MI, Sinchak K, Christensen A, Mermelstein PG, Micevych P. Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats. J Neurosci. 2007 Aug 29; 27(35):9294-300. PMID: 17728443.
      View in: PubMed
    43. Micevych P, Soma KK, Sinchak K. Neuroprogesterone: key to estrogen positive feedback? Brain Res Rev. 2008 Mar; 57(2):470-80. PMID: 17850878.
      View in: PubMed
    44. Quesada A, Romeo HE, Micevych P. Distribution and localization patterns of estrogen receptor-beta and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization of ERbeta and IGF-1R in substantia nigra. J Comp Neurol. 2007 Jul 01; 503(1):198-208. PMID: 17480015.
      View in: PubMed
    45. Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P. The same dorsal root ganglion neurons innervate uterus and colon in the rat. Neuroreport. 2007 Feb 12; 18(3):209-12. PMID: 17314658.
      View in: PubMed
    46. Sinchak K, Dewing P, Cook M, Micevych P. Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis. Horm Behav. 2007 Mar; 51(3):406-12. PMID: 17274997.
      View in: PubMed
    47. Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K. Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology. 2007 Feb; 148(2):782-9. PMID: 17095591.
      View in: PubMed
    48. Sinchak K, Romeo HE, Micevych PE. Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system. J Comp Neurol. 2006 May 10; 496(2):252-68. PMID: 16538678.
      View in: PubMed
    49. Dewing P, Chiang CW, Sinchak K, Sim H, Fernagut PO, Kelly S, Chesselet MF, Micevych PE, Albrecht KH, Harley VR, Vilain E. Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol. 2006 Feb 21; 16(4):415-20. PMID: 16488877.
      View in: PubMed
    50. Quesada A, Micevych P. Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats. Brain Res. 2006 Feb 16; 1073-1074:316-20. PMID: 16472782.
      View in: PubMed
    51. Sinchak K, Shahedi K, Dewing P, Micevych P. Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse. Neuroreport. 2005 Oct 17; 16(15):1697-700. PMID: 16189480.
      View in: PubMed
    52. Chaban VV, Micevych PE. Estrogen receptor-alpha mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons. J Neurosci Res. 2005 Jul 01; 81(1):31-7. PMID: 15952176.
      View in: PubMed
    53. Sinchak K, Mills RH, Eckersell CB, Micevych PE. Medial preoptic area delta-opioid receptors inhibit lordosis. Behav Brain Res. 2004 Dec 06; 155(2):301-6. PMID: 15364490.
      View in: PubMed
    54. Chaban VV, Lakhter AJ, Micevych P. A membrane estrogen receptor mediates intracellular calcium release in astrocytes. Endocrinology. 2004 Aug; 145(8):3788-95. PMID: 15131017.
      View in: PubMed
    55. Saldanha CJ, Schlinger BA, Micevych PE, Horvath TL. Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus. J Comp Neurol. 2004 Feb 16; 469(4):522-34. PMID: 14755533.
      View in: PubMed
    56. Mills RH, Sohn RK, Micevych PE. Estrogen-induced mu-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats. J Neurosci. 2004 Jan 28; 24(4):947-55. PMID: 14749439.
      View in: PubMed
    57. Quesada A, Micevych PE. Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxdopamine lesions. J Neurosci Res. 2004 Jan 01; 75(1):107-16. PMID: 14689453.
      View in: PubMed
    58. Sinchak K, Mills RH, Tao L, LaPolt P, Lu JK, Micevych P. Estrogen induces de novo progesterone synthesis in astrocytes. Dev Neurosci. 2003 Sep-Oct; 25(5):343-8. PMID: 14614261.
      View in: PubMed
    59. Micevych P, Sinchak K, Mills RH, Tao L, LaPolt P, Lu JK. The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats. Neuroendocrinology. 2003 Jul; 78(1):29-35. PMID: 12869797.
      View in: PubMed
    60. Sinchak K, Micevych P. Visualizing activation of opioid circuits by internalization of G protein-coupled receptors. Mol Neurobiol. 2003 Apr; 27(2):197-222. PMID: 12777688.
      View in: PubMed
    61. Micevych PE, Rissman EF, Gustafsson JA, Sinchak K. Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization. J Neurosci Res. 2003 Mar 15; 71(6):802-10. PMID: 12605406.
      View in: PubMed
    62. Micevych P, Chaban V, Quesada A, Sinchak K. Oestrogen modulates cholecystokinin: opioid interactions in the nervous system. Pharmacol Toxicol. 2002 Dec; 91(6):387-97. PMID: 12688384.
      View in: PubMed
    63. Mills RH, Romeo HE, Lu JK, Micevych PE. Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus rats. Brain Res. 2002 Nov 15; 955(1-2):200-6. PMID: 12419537.
      View in: PubMed
    64. Cristobal R, Popper P, Lopez I, Micevych P, De Vellis J, Honrubia V. In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs. Brain Res Mol Brain Res. 2002 Jun 15; 102(1-2):83-99. PMID: 12191497.
      View in: PubMed
    65. Micevych P, Sinchak K. Estrogen and endogenous opioids regulate CCK in reproductive circuits. Peptides. 2001 Aug; 22(8):1235-44. PMID: 11457516.
      View in: PubMed