Paul E Micevych

Title(s)Professor, Neurobiology
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    Title(s)Professor, Head and Neck Surgery

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    Modulation of sex steroid-induced female social behaviors in an animal model
    NIH R01HD098284Mar 5, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Physiology of hypothalamic neurosteroidal progesterone
    NIH R01HD042635Jul 1, 2002 - Jun 30, 2020
    Role: Principal Investigator
    Sex Steroid Activation of Opioid Circuits in the CNS
    NIH R01DA013185Mar 1, 2001 - Feb 28, 2018
    Role: Principal Investigator
    NIH R01NS039495Dec 10, 1999 - Nov 30, 2003
    Role: Principal Investigator
    NIH R01NS023468Apr 1, 1986 - Mar 31, 1989
    Role: Principal Investigator
    NIH R01NS021220Jul 1, 1984 - Mar 31, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hypothalamic Astrocyte Development and Physiology for Neuroprogesterone Induction of the Luteinizing Hormone Surge. Front Endocrinol (Lausanne). 2020; 11:420. Sinchak K, Mohr MA, Micevych PE. PMID: 32670203.
      View in: PubMed   Mentions:
    2. Optogenetic Activation of ß-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity. eNeuro. 2020 Jan/Feb; 7(1). Johnson C, Hong W, Micevych P. PMID: 31941660.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. ERa?4, an ERa splice variant missing exon4, interacts with caveolin-3 and mGluR2/3. J Neuroendocrinol. 2019 06; 31(6):e12725. Wong AM, Scott AK, Johnson CS, Mohr MA, Mittelman-Smith M, Micevych PE. PMID: 31050077.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala. Cell. 2019 02 21; 176(5):1206-1221.e18. Chen PB, Hu RK, Wu YE, Pan L, Huang S, Micevych PE, Hong W. PMID: 30773317.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    5. Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity. Horm Behav. 2018 08; 104:4-14. Micevych PE, Sinchak K. PMID: 29753716.
      View in: PubMed   Mentions: 5     Fields:    
    6. Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction. Trends Neurosci. 2017 11; 40(11):654-666. Micevych PE, Mermelstein PG, Sinchak K. PMID: 28969926.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    7. Integrating Neural Circuits Controlling Female Sexual Behavior. Front Syst Neurosci. 2017; 11:42. Micevych PE, Meisel RL. PMID: 28642689.
      View in: PubMed   Mentions:
    8. Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin Neurons. Neuroendocrinology. 2018; 106(2):101-115. Mittelman-Smith MA, Wong AM, Micevych PE. PMID: 28384629.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Actions of Steroids: New Neurotransmitters. J Neurosci. 2016 11 09; 36(45):11449-11458. Rudolph LM, Cornil CA, Mittelman-Smith MA, Rainville JR, Remage-Healey L, Sinchak K, Micevych PE. PMID: 27911748.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    10. Estradiol Membrane-Initiated Signaling and Female Reproduction. Compr Physiol. 2015 Jul 01; 5(3):1211-22. Micevych PE, Wong AM, Mittelman-Smith MA. PMID: 26140715.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. ß-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. PLoS One. 2015; 10(3):e0120530. Wong AM, Abrams MC, Micevych PE. PMID: 25803606.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons. Endocrinology. 2015 Jun; 156(6):2162-73. Mittelman-Smith MA, Wong AM, Kathiresan AS, Micevych PE. PMID: 25730107.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    13. Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology. 2014 Aug; 155(8):2976-85. Chen C, Kuo J, Wong A, Micevych P. PMID: 24877623.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    14. Modulation of the arcuate nucleus-medial preoptic nucleus lordosis regulating circuit: a role for GABAB receptors. Horm Behav. 2013 Jun; 64(1):136-43. Sinchak K, Dewing P, Ponce L, Gomez L, Christensen A, Berger M, Micevych P. PMID: 23756153.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    15. A Novel Membrane Estrogen Receptor Activated by STX Induces Female Sexual Receptivity through an Interaction with mGluR1a. Neuroendocrinology. 2013; 97(4):363-8. Christensen A, Micevych P. PMID: 23571598.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons. Steroids. 2013 Jun; 78(6):607-13. Dominguez R, Dewing P, Kuo J, Micevych P. PMID: 23296142.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    17. Membrane-initiated estradiol signaling regulates the central nervous system. Front Neuroendocrinol. 2012 Oct; 33(4):329-30. Micevych P. PMID: 23141474.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Membrane estrogen receptor regulation of hypothalamic function. Neuroendocrinology. 2012; 96(2):103-10. Micevych PE, Kelly MJ. PMID: 22538318.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    19. Membrane-initiated estradiol actions mediate structural plasticity and reproduction. Front Neuroendocrinol. 2012 Oct; 33(4):331-41. Micevych P, Christensen A. PMID: 22828999.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. CAV1 siRNA reduces membrane estrogen receptor-a levels and attenuates sexual receptivity. Endocrinology. 2012 Aug; 153(8):3872-7. Christensen A, Micevych P. PMID: 22669893.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    21. Neurosteroids, trigger of the LH surge. J Steroid Biochem Mol Biol. 2012 Aug; 131(1-2):57-65. Kuo J, Micevych P. PMID: 22326732.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    22. The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge. Front Endocrinol (Lausanne). 2011; 2:90. Micevych P, Sinchak K. PMID: 22654832.
      View in: PubMed   Mentions:
    23. Membrane-initiated estradiol signaling induces spinogenesis required for female sexual receptivity. J Neurosci. 2011 Nov 30; 31(48):17583-9. Christensen A, Dewing P, Micevych P. PMID: 22131419.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    24. Membrane-initiated estradiol signaling regulating sexual receptivity. Front Endocrinol (Lausanne). 2011; 2:26. Micevych PE, Dewing P. PMID: 22649369.
      View in: PubMed   Mentions:
    25. Estradiol attenuates the adenosine triphosphate-induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat dorsal root ganglion neurons. J Neurosci Res. 2011 Nov; 89(11):1707-10. Chaban V, Li J, McDonald JS, Rapkin A, Micevych P. PMID: 21793040.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    26. Sex differences in hypothalamic astrocyte response to estradiol stimulation. Biol Sex Differ. 2010 Nov 22; 1(1):7. Kuo J, Hamid N, Bondar G, Dewing P, Clarkson J, Micevych P. PMID: 21208471.
      View in: PubMed   Mentions: 28     Fields:    
    27. Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. J Neurosci. 2010 Sep 29; 30(39):12950-7. Kuo J, Hamid N, Bondar G, Prossnitz ER, Micevych P. PMID: 20881113.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    28. Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons. J Neurosci. 2010 Sep 22; 30(38):12589-96. Dominguez R, Micevych P. PMID: 20861365.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    29. Estrogen actions on neuroendocrine glia. Neuroendocrinology. 2010; 91(3):211-22. Micevych P, Bondar G, Kuo J. PMID: 20332598.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Estradiol-induced estrogen receptor-alpha trafficking. J Neurosci. 2009 Dec 02; 29(48):15323-30. Bondar G, Kuo J, Hamid N, Micevych P. PMID: 19955385.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    31. C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1. Exp Neurol. 2009 Dec; 220(2):255-66. Quesada A, Micevych P, Handforth A. PMID: 19735655.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Membrane estradiol signaling in the brain. Front Neuroendocrinol. 2009 Aug; 30(3):315-27. Micevych P, Dominguez R. PMID: 19416735.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    33. Physiology of membrane oestrogen receptor signalling in reproduction. J Neuroendocrinol. 2009 Mar; 21(4):249-56. Micevych P, Kuo J, Christensen A. PMID: 19207814.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    34. Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology. 2009 Mar; 150(3):1369-76. Kuo J, Hariri OR, Bondar G, Ogi J, Micevych P. PMID: 18948402.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    35. Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res. 2008 Sep; 86(12):2746-52. Li J, Micevych P, McDonald J, Rapkin A, Chaban V. PMID: 18478547.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    36. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol. 2008 Aug; 38(1):66-77. Micevych PE, Mermelstein PG. PMID: 18670908.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    37. Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats. Endocrinology. 2008 Dec; 149(12):5934-42. Dewing P, Christensen A, Bondar G, Micevych P. PMID: 18653714.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    38. Estradiol regulation of progesterone synthesis in the brain. Mol Cell Endocrinol. 2008 Aug 13; 290(1-2):44-50. Micevych P, Sinchak K. PMID: 18572304.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    39. PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease. Dev Neurobiol. 2008 Apr; 68(5):632-44. Quesada A, Lee BY, Micevych PE. PMID: 18278798.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    40. Synthesis and function of hypothalamic neuroprogesterone in reproduction. Endocrinology. 2008 Jun; 149(6):2739-42. Micevych P, Sinchak K. PMID: 18308840.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    41. Estrogen and progesterone modulate [35S]GTPgammaS binding to nociceptin receptors. Neuroendocrinology. 2008; 88(1):35-42. Quesada A, Micevych P. PMID: 18212517.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    42. Nervous system physiology regulated by membrane estrogen receptors. Rev Neurosci. 2008; 19(6):413-24. Mermelstein PG, Micevych PE. PMID: 19317180.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    43. Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats. J Neurosci. 2007 Aug 29; 27(35):9294-300. Dewing P, Boulware MI, Sinchak K, Christensen A, Mermelstein PG, Micevych P. PMID: 17728443.
      View in: PubMed   Mentions: 114     Fields:    Translation:Animals
    44. Neuroprogesterone: key to estrogen positive feedback? Brain Res Rev. 2008 Mar; 57(2):470-80. Micevych P, Soma KK, Sinchak K. PMID: 17850878.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    45. Distribution and localization patterns of estrogen receptor-beta and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization of ERbeta and IGF-1R in substantia nigra. J Comp Neurol. 2007 Jul 01; 503(1):198-208. Quesada A, Romeo HE, Micevych P. PMID: 17480015.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    46. The same dorsal root ganglion neurons innervate uterus and colon in the rat. Neuroreport. 2007 Feb 12; 18(3):209-12. Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P. PMID: 17314658.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis. Horm Behav. 2007 Mar; 51(3):406-12. Sinchak K, Dewing P, Cook M, Micevych P. PMID: 17274997.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    48. Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology. 2007 Feb; 148(2):782-9. Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K. PMID: 17095591.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    49. Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system. J Comp Neurol. 2006 May 10; 496(2):252-68. Sinchak K, Romeo HE, Micevych PE. PMID: 16538678.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    50. Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol. 2006 Feb 21; 16(4):415-20. Dewing P, Chiang CW, Sinchak K, Sim H, Fernagut PO, Kelly S, Chesselet MF, Micevych PE, Albrecht KH, Harley VR, Vilain E. PMID: 16488877.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    51. Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats. Brain Res. 2006 Feb 16; 1073-1074:316-20. Quesada A, Micevych P. PMID: 16472782.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    52. Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse. Neuroreport. 2005 Oct 17; 16(15):1697-700. Sinchak K, Shahedi K, Dewing P, Micevych P. PMID: 16189480.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    53. Estrogen receptor-alpha mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons. J Neurosci Res. 2005 Jul 01; 81(1):31-7. Chaban VV, Micevych PE. PMID: 15952176.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    54. Medial preoptic area delta-opioid receptors inhibit lordosis. Behav Brain Res. 2004 Dec 06; 155(2):301-6. Sinchak K, Mills RH, Eckersell CB, Micevych PE. PMID: 15364490.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    55. A membrane estrogen receptor mediates intracellular calcium release in astrocytes. Endocrinology. 2004 Aug; 145(8):3788-95. Chaban VV, Lakhter AJ, Micevych P. PMID: 15131017.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    56. Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus. J Comp Neurol. 2004 Feb 16; 469(4):522-34. Saldanha CJ, Schlinger BA, Micevych PE, Horvath TL. PMID: 14755533.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    57. Estrogen-induced mu-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats. J Neurosci. 2004 Jan 28; 24(4):947-55. Mills RH, Sohn RK, Micevych PE. PMID: 14749439.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    58. Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxdopamine lesions. J Neurosci Res. 2004 Jan 01; 75(1):107-16. Quesada A, Micevych PE. PMID: 14689453.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    59. Estrogen induces de novo progesterone synthesis in astrocytes. Dev Neurosci. 2003 Sep-Oct; 25(5):343-8. Sinchak K, Mills RH, Tao L, LaPolt P, Lu JK, Micevych P. PMID: 14614261.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    60. The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats. Neuroendocrinology. 2003 Jul; 78(1):29-35. Micevych P, Sinchak K, Mills RH, Tao L, LaPolt P, Lu JK. PMID: 12869797.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    61. Visualizing activation of opioid circuits by internalization of G protein-coupled receptors. Mol Neurobiol. 2003 Apr; 27(2):197-222. Sinchak K, Micevych P. PMID: 12777688.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    62. Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization. J Neurosci Res. 2003 Mar 15; 71(6):802-10. Micevych PE, Rissman EF, Gustafsson JA, Sinchak K. PMID: 12605406.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    63. Oestrogen modulates cholecystokinin: opioid interactions in the nervous system. Pharmacol Toxicol. 2002 Dec; 91(6):387-97. Micevych P, Chaban V, Quesada A, Sinchak K. PMID: 12688384.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    64. Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus rats. Brain Res. 2002 Nov 15; 955(1-2):200-6. Mills RH, Romeo HE, Lu JK, Micevych PE. PMID: 12419537.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    65. In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs. Brain Res Mol Brain Res. 2002 Jun 15; 102(1-2):83-99. Cristobal R, Popper P, Lopez I, Micevych P, De Vellis J, Honrubia V. PMID: 12191497.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    66. Estrogen and endogenous opioids regulate CCK in reproductive circuits. Peptides. 2001 Aug; 22(8):1235-44. Micevych P, Sinchak K. PMID: 11457516.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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