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Paul W Noble

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone(310) 423-1888
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Regulation of Progressive Pulmonary Fibrosis
    NIH/NHLBI R35HL150829Mar 1, 2020 - Feb 28, 2027
    Role: Principal Investigator
    Multidisciplinary Pulmonary Research Training Program
    NIH/NHLBI T32HL134637Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Targeting beta-arrestins in Pulmonary Fibrosis
    NIH/NHLBI R01HL122068Jan 1, 2015 - Nov 30, 2018
    Role: Co-Principal Investigator
    Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis and Chronic Allograft Dysfunction (CLAD)
    NIH/NHLBI P01HL108793Aug 1, 2012 - May 31, 2017
    Role: Principal Investigator
    Regulation of Pulmonary Fibrosis by CXCR3
    NIH/NHLBI R01HL077291Jul 1, 2004 - May 31, 2014
    Role: Principal Investigator
    Survivin Regulation of Pulmonary Fibrosis
    NIH/NHLBI R01HL073744Sep 15, 2003 - Jun 30, 2006
    Role: Principal Investigator
    Innate Immune Mechanisms of Non-infectious Lung Inflammation
    NIH/NIAID R01AI052201Jul 1, 2002 - Mar 31, 2014
    Role: Principal Investigator
    Matrix Regulation of Pulmonary Fibrosis
    NIH/NHLBI R01HL060539Sep 30, 1997 - Mar 31, 2006
    Role: Principal Investigator
    REGULATION OF MACROPHAGE PHENOTYPES IN LUNG REPAIR
    NIH/NHLBI K11HL002880Jul 1, 1992 - Jun 30, 1997
    Role: Principal Investigator
    Interdisciplinary Training Program in Lung Disease
    NIH/NHLBI T32HL007538Jul 1, 1982 - Mar 31, 2020
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 Sep 29. Yao C, Guan X, Carraro G, Parimon T, Liu X, Huang G, Mulay A, Soukiasian HJ, David G, Weigt SS, Belperio JA, Chen P, Jiang D, Noble PW, Stripp BR. PMID: 32991815.
      View in: PubMed   Mentions:    Fields:    
    2. Pre-existing traits associated with Covid-19 illness severity. PLoS One. 2020; 15(7):e0236240. Ebinger JE, Achamallah N, Ji H, Claggett BL, Sun N, Botting P, Nguyen TT, Luong E, Kim EH, Park E, Liu Y, Rosenberry R, Matusov Y, Zhao S, Pedraza I, Zaman T, Thompson M, Raedschelders K, Berg AH, Grein JD, Noble PW, Chugh SS, Bairey Merz CN, Marbán E, Van Eyk JE, Solomon SD, Albert CM, Chen P, Cheng S. PMID: 32702044.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    3. Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung. Am J Respir Crit Care Med. 2020 Jul 21. Carraro G, Mulay A, Yao C, Mizuno T, Konda B, Petrov M, Lafkas D, Arron JR, Hogaboam CM, Chen P, Jiang D, Noble PW, Randell SH, McQualter JL, Stripp BR. PMID: 32692579.
      View in: PubMed   Mentions:    Fields:    
    4. Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis. Int J Mol Sci. 2020 Mar 25; 21(7). Parimon T, Yao C, Stripp BR, Noble PW, Chen P. PMID: 32218238.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Risk factors for disease progression in idiopathic pulmonary fibrosis. Thorax. 2020 01; 75(1):78-80. Raghu G, Ley B, Brown KK, Cottin V, Gibson KF, Kaner RJ, Lederer DJ, Noble PW, Song JW, Wells AU, Whelan TP, Lynch DA, Humphries SM, Moreau E, Goodman K, Patterson SD, Smith V, Gong Q, Sundy JS, O'Riordan TG, Martinez FJ. PMID: 31611341.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Correction to: Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis. Adv Ther. 2019 Oct; 36(10):2927-2929. Glassberg MK, Nathan SD, Lin CY, Morgenthien EA, Stauffer JL, Chou W, Noble PW. PMID: 31502216.
      View in: PubMed   Mentions:    Fields:    
    7. Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. Sci Transl Med. 2019 09 25; 11(511). Ng B, Dong J, D'Agostino G, Viswanathan S, Widjaja AA, Lim WW, Ko NSJ, Tan J, Chothani SP, Huang B, Xie C, Pua CJ, Chacko AM, Guimarães-Camboa N, Evans SM, Byrne AJ, Maher TM, Liang J, Jiang D, Noble PW, Schafer S, Cook SA. PMID: 31554736.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis. Adv Ther. 2019 10; 36(10):2910-2926. Glassberg MK, Nathan SD, Lin CY, Morgenthien EA, Stauffer JL, Chou W, Noble PW. PMID: 31401786.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    9. Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles. JCI Insight. 2019 08 08; 5. Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P. PMID: 31393853.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Pirfenidone Treatment in Individuals with Idiopathic Pulmonary Fibrosis: Impact of Timing of Treatment Initiation. Ann Am Thorac Soc. 2019 07; 16(7):927-930. Maher TM, Lancaster LH, Jouneau S, Morrison L, Lederer DJ, Molina-Molina M, Bendstrup E, Kirchgaessler KU, Gilberg F, Axmann J, Petzinger U, Noble PW. PMID: 30950636.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Sci Transl Med. 2019 06 12; 11(496). Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E. PMID: 31189722.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Pirfenidone in patients with idiopathic pulmonary fibrosis and more advanced lung function impairment. Respir Med. 2019 07; 153:44-51. Nathan SD, Costabel U, Albera C, Behr J, Wuyts WA, Kirchgaessler KU, Stauffer JL, Morgenthien E, Chou W, Limb SL, Noble PW. PMID: 31153107.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    13. PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis. JCI Insight. 2019 03 21; 4(6). Geng Y, Liu X, Liang J, Habiel DM, Kulur V, Coelho AL, Deng N, Xie T, Wang Y, Liu N, Huang G, Kurkciyan A, Liu Z, Tang J, Hogaboam CM, Jiang D, Noble PW. PMID: 30763282.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. Effect of pirfenidone in patients with more advanced idiopathic pulmonary fibrosis. Respir Res. 2019 Mar 12; 20(1):55. Costabel U, Albera C, Glassberg MK, Lancaster LH, Wuyts WA, Petzinger U, Gilberg F, Kirchgaessler KU, Noble PW. PMID: 30866942.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    15. Mitogen-activated Protein Kinase-activated Protein Kinase 2 Inhibition Attenuates Fibroblast Invasion and Severe Lung Fibrosis. Am J Respir Cell Mol Biol. 2019 01; 60(1):41-48. Liang J, Liu N, Liu X, Mena JM, Xie T, Geng Y, Huan C, Zhang Y, Taghavifar F, Huang G, Kurkciyan A, Barron V, Jiang D, Noble PW. PMID: 30130411.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Dose modification and dose intensity during treatment with pirfenidone: analysis of pooled data from three multinational phase III trials. BMJ Open Respir Res. 2018; 5(1):e000323. Nathan SD, Lancaster LH, Albera C, Glassberg MK, Swigris JJ, Gilberg F, Kirchgaessler KU, Limb SL, Petzinger U, Noble PW. PMID: 30116539.
      View in: PubMed   Mentions:
    17. Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2018 06 01; 197(11):1443-1456. Espindola MS, Habiel DM, Narayanan R, Jones I, Coelho AL, Murray LA, Jiang D, Noble PW, Hogaboam CM. PMID: 29634284.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis. Cell Rep. 2018 03 27; 22(13):3625-3640. Xie T, Wang Y, Deng N, Huang G, Taghavifar F, Geng Y, Liu N, Kulur V, Yao C, Chen P, Liu Z, Stripp B, Tang J, Liang J, Noble PW, Jiang D. PMID: 29590628.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    19. Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic? Lancet Respir Med. 2018 02; 6(2):154-160. Wolters PJ, Blackwell TS, Eickelberg O, Loyd JE, Kaminski N, Jenkins G, Maher TM, Molina-Molina M, Noble PW, Raghu G, Richeldi L, Schwarz MI, Selman M, Wuyts WA, Schwartz DA. PMID: 29413083.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease. Am J Respir Cell Mol Biol. 2017 12; 57(6):702-710. Walker JKL, Theriot BS, Ghio M, Trempus CS, Wong JE, McQuade VL, Liang J, Jiang D, Noble PW, Garantziotis S, Kraft M, Ingram JL. PMID: 28787175.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis. Am J Respir Cell Mol Biol. 2017 12; 57(6):721-732. Xie T, Liang J, Geng Y, Liu N, Kurkciyan A, Kulur V, Leng D, Deng N, Liu Z, Song J, Chen P, Noble PW, Jiang D. PMID: 28799781.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. An Open-Label Study of the Long-Term Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (RECAP). Respiration. 2017; 94(5):408-415. Costabel U, Albera C, Lancaster LH, Lin CY, Hormel P, Hulter HN, Noble PW. PMID: 28898890.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    23. miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways. JCI Insight. 2016 12 08; 1(20):e90301. Ge L, Habiel DM, Hansbro PM, Kim RY, Gharib SA, Edelman JD, Königshoff M, Parimon T, Brauer R, Huang Y, Allen J, Jiang D, Kurkciyan AA, Mizuno T, Stripp BR, Noble PW, Hogaboam CM, Chen P. PMID: 27942594.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial. Lancet Respir Med. 2017 01; 5(1):22-32. Raghu G, Brown KK, Collard HR, Cottin V, Gibson KF, Kaner RJ, Lederer DJ, Martinez FJ, Noble PW, Song JW, Wells AU, Whelan TP, Wuyts W, Moreau E, Patterson SD, Smith V, Bayly S, Chien JW, Gong Q, Zhang JJ, O'Riordan TG. PMID: 27939076.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCTClinical Trials
    25. Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis. Lancet Respir Med. 2017 01; 5(1):33-41. Nathan SD, Albera C, Bradford WZ, Costabel U, Glaspole I, Glassberg MK, Kardatzke DR, Daigl M, Kirchgaessler KU, Lancaster LH, Lederer DJ, Pereira CA, Swigris JJ, Valeyre D, Noble PW. PMID: 27876247.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    26. Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice. Nat Med. 2016 11; 22(11):1285-1293. Liang J, Zhang Y, Xie T, Liu N, Chen H, Geng Y, Kurkciyan A, Mena JM, Stripp BR, Jiang D, Noble PW. PMID: 27694932.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    27. Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J Biol Chem. 2016 09 09; 291(37):19257-8. Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW. PMID: 27613954.
      View in: PubMed   Mentions: 2     Fields:    
    28. Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. J Clin Invest. 2016 09 01; 126(9):3626. Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW. PMID: 27548522.
      View in: PubMed   Mentions: 5     Fields:    
    29. Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. J Clin Invest. 2016 08 01; 126(8):3063-79. Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW. PMID: 27400124.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. Matrix Biol. 2016 09; 55:35-48. Li Y, Liang J, Yang T, Monterrosa Mena J, Huan C, Xie T, Kurkciyan A, Liu N, Jiang D, Noble PW. PMID: 26987798.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    31. Effect of continued treatment with pirfenidone following clinically meaningful declines in forced vital capacity: analysis of data from three phase 3 trials in patients with idiopathic pulmonary fibrosis. Thorax. 2016 05; 71(5):429-35. Nathan SD, Albera C, Bradford WZ, Costabel U, du Bois RM, Fagan EA, Fishman RS, Glaspole I, Glassberg MK, Glasscock KF, King TE, Lancaster L, Lederer DJ, Lin Z, Pereira CA, Swigris JJ, Valeyre D, Noble PW, Wells AU. PMID: 26968970.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    32. Correction: Ozone Inhalation Promotes CX3CR1-Dependent Maturation of Resident Lung Macrophages That Limit Oxidative Stress and Inflammation. J Immunol. 2016 Mar 01; 196(5):2424. Tighe RM, Li Z, Potts EN, Frush S, Liu N, Gunn MD, Foster WM, Noble PW, Hollingsworth JW. PMID: 26896483.
      View in: PubMed   Mentions: 1     Fields:    
    33. Safety of pirfenidone in patients with idiopathic pulmonary fibrosis: integrated analysis of cumulative data from 5 clinical trials. BMJ Open Respir Res. 2016; 3(1):e000105. Lancaster L, Albera C, Bradford WZ, Costabel U, du Bois RM, Fagan EA, Fishman RS, Glaspole I, Glassberg MK, King TE, Lederer DJ, Lin Z, Nathan SD, Pereira CA, Swigris JJ, Valeyre D, Noble PW. PMID: 26835133.
      View in: PubMed   Mentions:
    34. Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):13-24. Yu YR, Hotten DF, Malakhau Y, Volker E, Ghio AJ, Noble PW, Kraft M, Hollingsworth JW, Gunn MD, Tighe RM. PMID: 26267148.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    35. Pirfenidone for idiopathic pulmonary fibrosis: analysis of pooled data from three multinational phase 3 trials. Eur Respir J. 2016 Jan; 47(1):243-53. Noble PW, Albera C, Bradford WZ, Costabel U, du Bois RM, Fagan EA, Fishman RS, Glaspole I, Glassberg MK, Lancaster L, Lederer DJ, Leff JA, Nathan SD, Pereira CA, Swigris JJ, Valeyre D, King TE. PMID: 26647432.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    36. Pirfenidone Initiates a New Era in the Treatment of Idiopathic Pulmonary Fibrosis. Annu Rev Med. 2016; 67:487-95. Selvaggio AS, Noble PW. PMID: 26565677.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    37. Hyaluronan as a therapeutic target in human diseases. Adv Drug Deliv Rev. 2016 Feb 01; 97:186-203. Liang J, Jiang D, Noble PW. PMID: 26541745.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    38. The Role of TGF-ß in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant. 2016 Feb; 16(2):640-9. DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL, Noble PW, Palmer SM, Fishbein MC, Kubak BM, Ardehali A, Ross DJ, Saggar R, Lynch JP, Elashoff RM, Belperio JA. PMID: 26461171.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    39. Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo. Sci Rep. 2015 Oct 07; 5:14910. Huan C, Yang T, Liang J, Xie T, Cheng L, Liu N, Kurkciyan A, Monterrosa Mena J, Wang C, Dai H, Noble PW, Jiang D. PMID: 26442443.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    40. Sensitivity Analyses of the Change in FVC in a Phase 3 Trial of Pirfenidone for Idiopathic Pulmonary Fibrosis. Chest. 2015 Jul; 148(1):196-201. Lederer DJ, Bradford WZ, Fagan EA, Glaspole I, Glassberg MK, Glasscock KF, Kardatzke D, King TE, Lancaster LH, Nathan SD, Pereira CA, Sahn SA, Swigris JJ, Noble PW. PMID: 25856121.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    41. Validation of test performance characteristics and minimal clinically important difference of the 6-minute walk test in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Jul; 109(7):914-22. Nathan SD, du Bois RM, Albera C, Bradford WZ, Costabel U, Kartashov A, Noble PW, Sahn SA, Valeyre D, Weycker D, King TE. PMID: 25956020.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    42. Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med. 2015 Feb 09; 212(2):235-52. Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble PW, Jiang D, Ning W. PMID: 25584011.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    43. Analysis of lung function and survival in RECAP: An open-label extension study of pirfenidone in patients with idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2014 Oct 20; 31(3):198-205. Costabel U, Albera C, Bradford WZ, Hormel P, King TE, Noble PW, Sahn SA, Valeyre D, du Bois RM. PMID: 25363219.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    44. Familial and sporadic idiopathic pulmonary fibrosis: making the diagnosis from peripheral blood. BMC Genomics. 2014 Oct 16; 15:902. Meltzer EB, Barry WT, Yang IV, Brown KK, Schwarz MI, Patel H, Ashley A, Noble PW, Schwartz DA, Steele MP. PMID: 25318837.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Treatments for idiopathic pulmonary fibrosis. N Engl J Med. 2014 08 21; 371(8):783-4. King TE, Noble PW, Bradford WZ. PMID: 25147884.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    46. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014 May 29; 370(22):2071-82. Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR. PMID: 24836310.
      View in: PubMed   Mentions: 671     Fields:    Translation:HumansCTClinical Trials
    47. Comprehensive assessment of the long-term safety of pirfenidone in patients with idiopathic pulmonary fibrosis. Respirology. 2014 Jul; 19(5):740-7. Valeyre D, Albera C, Bradford WZ, Costabel U, King TE, Leff JA, Noble PW, Sahn SA, du Bois RM. PMID: 24836849.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    48. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014 May 29; 370(22):2083-92. King TE, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L, Lederer DJ, Nathan SD, Pereira CA, Sahn SA, Sussman R, Swigris JJ, Noble PW. PMID: 24836312.
      View in: PubMed   Mentions: 629     Fields:    Translation:HumansCTClinical Trials
    49. Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis. . 2014 Jun 01; 306(11):C987-96. Barkauskas CE, Noble PW. PMID: 24740535.
      View in: PubMed   Mentions:
    50. Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute. Am J Pathol. 2014 Jun; 184(6):1643-51. Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ. PMID: 24726499.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    51. All-cause mortality rate in patients with idiopathic pulmonary fibrosis. Implications for the design and execution of clinical trials. Am J Respir Crit Care Med. 2014 Apr 01; 189(7):825-31. King TE, Albera C, Bradford WZ, Costabel U, du Bois RM, Leff JA, Nathan SD, Sahn SA, Valeyre D, Noble PW. PMID: 24476390.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    52. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. PMID: 24160862.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    53. 6-Minute walk distance is an independent predictor of mortality in patients with idiopathic pulmonary fibrosis. Eur Respir J. 2014 May; 43(5):1421-9. du Bois RM, Albera C, Bradford WZ, Costabel U, Leff JA, Noble PW, Sahn SA, Valeyre D, Weycker D, King TE. PMID: 24311766.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCTClinical Trials
    54. Type 2 alveolar cells are stem cells in adult lung. J Clin Invest. 2013 Jul; 123(7):3025-36. Barkauskas CE, Cronce MJ, Rackley CR, Bowie EJ, Keene DR, Stripp BR, Randell SH, Noble PW, Hogan BL. PMID: 23921127.
      View in: PubMed   Mentions: 343     Fields:    Translation:AnimalsCells
    55. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PLoS One. 2013; 8(4):e60560. Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. PMID: 23637753.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    56. ß-Arrestins in the immune system. Prog Mol Biol Transl Sci. 2013; 118:359-93. Jiang D, Xie T, Liang J, Noble PW. PMID: 23764061.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    57. Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. Stem Cells. 2012 Sep; 30(9):1948-60. Chen H, Matsumoto K, Brockway BL, Rackley CR, Liang J, Lee JH, Jiang D, Noble PW, Randell SH, Kim CF, Stripp BR. PMID: 22696116.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    58. Pulmonary fibrosis: patterns and perpetrators. J Clin Invest. 2012 Aug; 122(8):2756-62. Noble PW, Barkauskas CE, Jiang D. PMID: 22850886.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimals
    59. Take a deep breath: pulmonary research inspires. J Clin Invest. 2012 Aug; 122(8):2722-3. Noble PW. PMID: 22850881.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    60. Idiopathic pulmonary fibrosis: lung function is a clinically meaningful endpoint for phase III trials. Am J Respir Crit Care Med. 2012 Oct 15; 186(8):712-5. du Bois RM, Nathan SD, Richeldi L, Schwarz MI, Noble PW. PMID: 22798316.
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    61. Chronic treatment in vivo with ß-adrenoceptor agonists induces dysfunction of airway ß(2) -adrenoceptors and exacerbates lung inflammation in mice. Br J Pharmacol. 2012 Apr; 165(7):2365-77. Lin R, Degan S, Theriot BS, Fischer BM, Strachan RT, Liang J, Pierce RA, Sunday ME, Noble PW, Kraft M, Brody AR, Walker JK. PMID: 22013997.
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    62. MicroRNA-127 inhibits lung inflammation by targeting IgG Fc? receptor I. J Immunol. 2012 Mar 01; 188(5):2437-44. Xie T, Liang J, Liu N, Wang Q, Li Y, Noble PW, Jiang D. PMID: 22287715.
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    63. A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. . 2012 May 01; 302(9):L933-40. Liang J, Jung Y, Tighe RM, Xie T, Liu N, Leonard M, Gunn MD, Jiang D, Noble PW. PMID: 22287613.
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    64. Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):525-36. Aono Y, Ledford JG, Mukherjee S, Ogawa H, Nishioka Y, Sone S, Beers MF, Noble PW, Wright JR. PMID: 22198976.
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    65. Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation. Am J Respir Cell Mol Biol. 2012 May; 46(5):592-8. Jiang D, Liang J, Guo R, Xie T, Kelly FL, Martinu T, Yang T, Lovgren AK, Chia J, Liu N, Jung Y, Palmer SM, Noble PW. PMID: 22162905.
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    66. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):E1475-83. Rock JR, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, Noble PW, Hogan BL. PMID: 22123957.
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    67. Role of CD44 in the organization of keratinocyte pericellular hyaluronan. Histochem Cell Biol. 2012 Jan; 137(1):107-20. Pasonen-Seppänen S, Hyttinen JM, Rilla K, Jokela T, Noble PW, Tammi M, Tammi R. PMID: 22072421.
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    68. Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle. BMC Med Genomics. 2011 Oct 05; 4:70. Meltzer EB, Barry WT, D'Amico TA, Davis RD, Lin SS, Onaitis MW, Morrison LD, Sporn TA, Steele MP, Noble PW. PMID: 21974901.
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    69. Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med. 2011 Sep 22; 365(12):1079-87. Richeldi L, Costabel U, Selman M, Kim DS, Hansell DM, Nicholson AG, Brown KK, Flaherty KR, Noble PW, Raghu G, Brun M, Gupta A, Juhel N, Klüglich M, du Bois RM. PMID: 21992121.
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    70. Forced vital capacity in patients with idiopathic pulmonary fibrosis: test properties and minimal clinically important difference. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1382-9. du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, King TE, Lancaster L, Noble PW, Sahn SA, Thomeer M, Valeyre D, Wells AU. PMID: 21940789.
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    71. Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase. J Allergy Ther. 2011 Sep 20; 2011(Suppl 1). Tighe RM, Potts EN, Feng F, Li Z, Frush B, He YW, Corry DB, Noble PW, Hollingsworth JW. PMID: 23560245.
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    72. Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J Immunol. 2011 Nov 01; 187(9):4800-8. Tighe RM, Li Z, Potts EN, Frush S, Liu N, Gunn MD, Foster WM, Noble PW, Hollingsworth JW. PMID: 21930959.
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    73. Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):459-66. du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Raghu G, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, King TE. PMID: 21616999.
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    74. End of an ERA: lessons from negative clinical trials in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jul 01; 184(1):4-5. Noble PW, Richeldi L, Kaminski N. PMID: 21737589.
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    75. Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44. J Exp Med. 2011 Jul 04; 208(7):1459-71. Li Y, Jiang D, Liang J, Meltzer EB, Gray A, Miura R, Wogensen L, Yamaguchi Y, Noble PW. PMID: 21708929.
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    76. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. PMID: 21653526.
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    77. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. Lancet. 2011 May 21; 377(9779):1760-9. Noble PW, Albera C, Bradford WZ, Costabel U, Glassberg MK, Kardatzke D, King TE, Lancaster L, Sahn SA, Szwarcberg J, Valeyre D, du Bois RM. PMID: 21571362.
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    78. Role of hyaluronan and hyaluronan-binding proteins in human asthma. J Allergy Clin Immunol. 2011 Aug; 128(2):403-411.e3. Liang J, Jiang D, Jung Y, Xie T, Ingram J, Church T, Degan S, Leonard M, Kraft M, Noble PW. PMID: 21570715.
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    79. Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3. J Heart Lung Transplant. 2011 Jun; 30(6):717-25. Martinu T, Kinnier CV, Gowdy KM, Kelly FL, Snyder LD, Jiang D, Foster WM, Garantziotis S, Belperio JA, Noble PW, Palmer SM. PMID: 21444213.
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    80. Airway fibroblasts in asthma manifest an invasive phenotype. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1625-32. Ingram JL, Huggins MJ, Church TD, Li Y, Francisco DC, Degan S, Firszt R, Beaver DM, Lugogo NL, Wang Y, Sunday ME, Noble PW, Kraft M. PMID: 21471104.
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    81. ß-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Sci Transl Med. 2011 Mar 16; 3(74):74ra23. Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW. PMID: 21411739.
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    82. Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A. Respir Care. 2011 Jul; 56(7):941-6. Turner DA, Rehder KJ, Peterson-Carmichael SL, Ozment CP, Al-Hegelan MS, Williford WL, Peters MA, Noble PW, Cheifetz IM. PMID: 21352668.
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    83. Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):781-8. Tighe RM, Liang J, Liu N, Jung Y, Jiang D, Gunn MD, Noble PW. PMID: 21330464.
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    84. Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. Physiol Genomics. 2011 May 13; 43(9):479-87. Xie T, Liang J, Guo R, Liu N, Noble PW, Jiang D. PMID: 21266501.
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    85. Hyaluronan as an immune regulator in human diseases. Physiol Rev. 2011 Jan; 91(1):221-64. Jiang D, Liang J, Noble PW. PMID: 21248167.
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    86. Six-minute-walk test in idiopathic pulmonary fibrosis: test validation and minimal clinically important difference. Am J Respir Crit Care Med. 2011 May 01; 183(9):1231-7. du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, King TE. PMID: 21131468.
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    87. CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia. Am J Pathol. 2010 Nov; 177(5):2483-94. van der Windt GJ, Florquin S, de Vos AF, van't Veer C, Queiroz KC, Liang J, Jiang D, Noble PW, van der Poll T. PMID: 20864681.
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    88. Regulation of non-infectious lung injury, inflammation, and repair by the extracellular matrix glycosaminoglycan hyaluronan. Anat Rec (Hoboken). 2010 Jun; 293(6):982-5. Jiang D, Liang J, Noble PW. PMID: 20186964.
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    89. Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. J Clin Invest. 2010 Jun; 120(6):2049-57. Jiang D, Liang J, Campanella GS, Guo R, Yu S, Xie T, Liu N, Jung Y, Homer R, Meltzer EB, Li Y, Tager AM, Goetinck PF, Luster AD, Noble PW. PMID: 20484822.
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    90. The role of surfactant protein A in bleomycin-induced acute lung injury. Am J Respir Crit Care Med. 2010 Jun 15; 181(12):1336-44. Goto H, Ledford JG, Mukherjee S, Noble PW, Williams KL, Wright JR. PMID: 20167853.
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    91. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet. 2009 Jul 18; 374(9685):222-8. King TE, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, du Bois RM. PMID: 19570573.
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    92. Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J Biol Chem. 2009 Apr 24; 284(17):11309-17. Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW. PMID: 19164299.
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    93. Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):939-47. Garantziotis S, Zudaire E, Trempus CS, Hollingsworth JW, Jiang D, Lancaster LH, Richardson E, Zhuo L, Cuttitta F, Brown KK, Noble PW, Kimata K, Schwartz DA. PMID: 18703791.
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    94. Idiopathic pulmonary fibrosis. Orphanet J Rare Dis. 2008 Mar 26; 3:8. Meltzer EB, Noble PW. PMID: 18366757.
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    95. Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan. J Biol Chem. 2008 Mar 07; 283(10):6058-66. Gao F, Koenitzer JR, Tobolewski JM, Jiang D, Liang J, Noble PW, Oury TD. PMID: 18165226.
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    96. CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. J Immunol. 2007 Feb 15; 178(4):2469-75. Liang J, Jiang D, Griffith J, Yu S, Fan J, Zhao X, Bucala R, Noble PW. PMID: 17277154.
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    97. Idiopathic pulmonary fibrosis and pulmonary hypertension: connecting the dots. Am J Respir Crit Care Med. 2007 May 01; 175(9):875-80. Nathan SD, Noble PW, Tuder RM. PMID: 17255562.
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    98. Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol. 2007; 23:435-61. Jiang D, Liang J, Noble PW. PMID: 17506690.
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    99. Patient experiences with pulmonary fibrosis. Respir Med. 2007 Jun; 101(6):1350-4. Collard HR, Tino G, Noble PW, Shreve MA, Michaels M, Carlson B, Schwarz MI. PMID: 17107778.
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    100. The role of hyaluronan degradation products as innate alloimmune agonists. Am J Transplant. 2006 Nov; 6(11):2622-35. Tesar BM, Jiang D, Liang J, Palmer SM, Noble PW, Goldstein DR. PMID: 17049055.
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    101. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity. 2006 Oct; 25(4):595-606. Shi X, Leng L, Wang T, Wang W, Du X, Li J, McDonald C, Chen Z, Murphy JW, Lolis E, Noble P, Knudson W, Bucala R. PMID: 17045821.
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    102. The role of Toll-like receptors in non-infectious lung injury. Cell Res. 2006 Aug; 16(8):693-701. Jiang D, Liang J, Li Y, Noble PW. PMID: 16894359.
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    103. Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity. Proc Am Thorac Soc. 2006 Jul; 3(5):401-4. Noble PW, Jiang D. PMID: 16799081.
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    104. Idiopathic pulmonary fibrosis: natural history and prognosis. Clin Chest Med. 2006 Mar; 27(1 Suppl 1):S11-6, v. Noble PW. PMID: 16545628.
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    105. Case study review. Chest. 2005 Nov; 128(5 Suppl 1):540S-546S. Noble PW, Tanoue L, Homer R. PMID: 16304245.
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    106. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005 Nov; 11(11):1173-9. Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. PMID: 16244651.
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    107. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol. 2005 Oct 15; 175(8):4834-8. Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. PMID: 16210584.
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    108. A critical assessment of treatment options for idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct; 22(3):167-74. Shah NR, Noble P, Jackson RM, King TE, Nathan SD, Padilla M, Raghu G, Rhodes MB, Schwarz M, Tino G, Dubois RW. PMID: 16315778.
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    109. Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2005 Aug; 33(2):113-20. Noble PW, Homer RJ. PMID: 16024580.
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    110. The clinical course of patients with idiopathic pulmonary fibrosis. Ann Intern Med. 2005 Jun 21; 142(12 Pt 1):963-7. Martinez FJ, Safrin S, Weycker D, Starko KM, Bradford WZ, King TE, Flaherty KR, Schwartz DA, Noble PW, Raghu G, Brown KK. PMID: 15968010.
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    111. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2005 Feb 15; 174(4):2305-13. Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA. PMID: 15699166.
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    112. Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis. Chest. 2005 Jan; 127(1):171-7. King TE, Safrin S, Starko KM, Brown KK, Noble PW, Raghu G, Schwartz DA. PMID: 15653980.
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    113. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clin Chest Med. 2004 Dec; 25(4):749-58, vii. Noble PW, Homer RJ. PMID: 15564020.
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    114. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med. 2004 Aug 02; 200(3):377-89. Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. PMID: 15289506.
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    115. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest. 2004 Jul; 114(2):291-9. Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. PMID: 15254596.
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    116. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2004 Jan 08; 350(2):125-33. Raghu G, Brown KK, Bradford WZ, Starko K, Noble PW, Schwartz DA, King TE. PMID: 14711911.
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    117. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J Biol Chem. 2004 Mar 12; 279(11):10677-84. Zhang X, Shan P, Jiang D, Noble PW, Abraham NG, Kappas A, Lee PJ. PMID: 14688267.
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    118. Time will tell: predicting survival in idiopathic interstitial pneumonia. Am J Respir Crit Care Med. 2003 Sep 01; 168(5):510-1. Noble PW, Morris DG. PMID: 12941653.
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    119. Idiopathic pulmonary fibrosis. New insights into classification and pathogenesis usher in a new era therapeutic approaches. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Suppl):S27-31. Noble PW. PMID: 14503550.
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    120. CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am J Pathol. 2002 Dec; 161(6):2219-28. Wang Q, Teder P, Judd NP, Noble PW, Doerschuk CM. PMID: 12466136.
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    121. Resolution of lung inflammation by CD44. Science. 2002 Apr 05; 296(5565):155-8. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM, Noble PW. PMID: 11935029.
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    122. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2002 Mar 15; 168(6):2953-62. Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA. PMID: 11884467.
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    123. Hyaluronan and its catabolic products in tissue injury and repair. Matrix Biol. 2002 Jan; 21(1):25-9. Noble PW. PMID: 11827789.
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    124. Signaling properties of hyaluronan receptors. J Biol Chem. 2002 Feb 15; 277(7):4589-92. Turley EA, Noble PW, Bourguignon LY. PMID: 11717317.
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    125. Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S67-70. Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA. PMID: 11734470.
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    126. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 2001 Sep 17; 194(6):809-21. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA. PMID: 11560996.
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    127. Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages. . 2000 Oct; 279(4):L707-15. Horton MR, Olman MA, Bao C, White KE, Choi AM, Chin BY, Noble PW, Lowenstein CJ. PMID: 11000131.
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    128. A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol. 2000 Jul; 23(1):7-10. Teder P, Noble PW. PMID: 10873147.
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    129. Extensive surface phenotyping of alveolar macrophages in interstitial lung disease. Clin Immunol. 2000 Jan; 94(1):33-41. Taylor ML, Noble PW, White B, Wise R, Liu MC, Bochner BS. PMID: 10607488.
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    130. Hyaluronan fragments induce plasminogen activator inhibitor-1 and inhibit urokinase activity in mouse alveolar macrophages: a potential mechanism for impaired fibrinolytic activity in acute lung injury. Chest. 1999 Jul; 116(1 Suppl):17S. Horton MR, Olman MA, Noble PW. PMID: 10424564.
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    131. Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages. J Immunol. 1999 Apr 01; 162(7):4171-6. Horton MR, Shapiro S, Bao C, Lowenstein CJ, Noble PW. PMID: 10201943.
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    132. Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. J Biol Chem. 1998 Dec 25; 273(52):35088-94. Horton MR, McKee CM, Bao C, Liao F, Farber JM, Hodge-DuFour J, Puré E, Oliver BL, Wright TM, Noble PW. PMID: 9857043.
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    133. Pulmonary manifestations of Sjögren's syndrome. Clin Chest Med. 1998 Dec; 19(4):687-99, viii. Cain HC, Noble PW, Matthay RA. PMID: 9917960.
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    134. Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism for the anti-inflammatory activities of tumor necrosis factor. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13806-11. Hodge-Dufour J, Marino MW, Horton MR, Jungbluth A, Burdick MD, Strieter RM, Noble PW, Hunter CA, Puré E. PMID: 9811882.
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    135. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group. Lancet. 1998 Aug 01; 352(9125):343-6. Snijders RJ, Noble P, Sebire N, Souka A, Nicolaides KH. PMID: 9717920.
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    136. Regulation of hyaluronan-induced chemokine gene expression by IL-10 and IFN-gamma in mouse macrophages. J Immunol. 1998 Mar 15; 160(6):3023-30. Horton MR, Burdick MD, Strieter RM, Bao C, Noble PW. PMID: 9510207.
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    137. Leptin regulates proinflammatory immune responses. FASEB J. 1998 Jan; 12(1):57-65. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM. PMID: 9438411.
      View in: PubMed   Mentions: 286     Fields:    Translation:AnimalsCells
    138. Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. Hepatology. 1998 Jan; 27(1):86-92. Rockey DC, Chung JJ, McKee CM, Noble PW. PMID: 9425922.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    139. Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages. J Immunol. 1997 Sep 01; 159(5):2492-500. Hodge-Dufour J, Noble PW, Horton MR, Bao C, Wysoka M, Burdick MD, Strieter RM, Trinchieri G, Puré E. PMID: 9278343.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    140. Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. J Biol Chem. 1997 Mar 21; 272(12):8013-8. McKee CM, Lowenstein CJ, Horton MR, Wu J, Bao C, Chin BY, Choi AM, Noble PW. PMID: 9065473.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    141. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest. 1996 Nov 15; 98(10):2403-13. McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, Bao C, Noble PW. PMID: 8941660.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    142. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol. 1996 Jun 15; 156(12):4952-60. Moller DR, Forman JD, Liu MC, Noble PW, Greenlee BM, Vyas P, Holden DA, Forrester JM, Lazarus A, Wysocka M, Trinchieri G, Karp C. PMID: 8648147.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    143. Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J Exp Med. 1996 May 01; 183(5):2373-8. Noble PW, McKee CM, Cowman M, Shin HS. PMID: 8642348.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    144. Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-alpha and prostaglandin E2. J Immunol. 1995 Aug 15; 155(4):2123-33. Fournier T, Riches DW, Winston BW, Rose DM, Young SK, Noble PW, Lake FR, Henson PM. PMID: 7636260.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    145. Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2. Mol Cell Biol. 1994 May; 14(5):2914-25. Shin HS, Drysdale BE, Shin ML, Noble PW, Fisher SN, Paznekas WA. PMID: 7513046.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    146. Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha. J Clin Invest. 1994 Apr; 93(4):1661-9. Lake FR, Noble PW, Henson PM, Riches DW. PMID: 7512988.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    147. Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells. J Immunol. 1993 Oct 15; 151(8):4274-85. Fadok VA, Laszlo DJ, Noble PW, Weinstein L, Riches DW, Henson PM. PMID: 8409401.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    148. Development of functional diversity in mouse macrophages. Mutual exclusion of two phenotypic states. Am J Pathol. 1993 Aug; 143(2):587-97. Laszlo DJ, Henson PM, Remigio LK, Weinstein L, Sable C, Noble PW, Riches DW. PMID: 8342604.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    149. Transforming growth factor-beta primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism. J Immunol. 1993 Jul 15; 151(2):979-89. Noble PW, Henson PM, Lucas C, Mora-Worms M, Carré PC, Riches DW. PMID: 8335923.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    150. Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. J Clin Invest. 1993 Jun; 91(6):2368-77. Noble PW, Lake FR, Henson PM, Riches DW. PMID: 8514850.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    151. The ability to recognize phosphatidylserine on apoptotic cells is an inducible function in murine bone marrow-derived macrophages. Chest. 1993 Feb; 103(2 Suppl):102S. Fadok VA, Voelker DR, Campbell PA, Bratton DL, Cohen JJ, Noble PW, Riches DW, Henson PM. PMID: 8381344.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    152. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest. 1991 Dec; 88(6):1802-10. Carré PC, Mortenson RL, King TE, Noble PW, Sable CL, Riches DW. PMID: 1752942.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    153. Insulin-like growth factor-1 (IGF-1) mRNA expression in bone marrow derived macrophages is stimulated by chrysotile asbestos and bleomycin. A potential marker for a reparative macrophage phenotype. Chest. 1991 Mar; 99(3 Suppl):79S-80S. Noble PW, Henson PM, Riches DW. PMID: 1705203.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    154. The pulmonary complications of bone marrow transplantation in adults. West J Med. 1989 Apr; 150(4):443-9. Noble PW. PMID: 2660416.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    155. Respiratory diseases in pregnancy. Obstet Gynecol Clin North Am. 1988 Jun; 15(2):391-428. Noble PW, Lavee AE, Jacobs MM. PMID: 3067169.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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