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The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant. Glycobiology. 2024 03 26; 34(2).
Pegg CL, Modhiran N, Parry RH, Liang B, Amarilla AA, Khromykh AA, Burr L, Young PR, Chappell K, Schulz BL, Watterson D. PMID: 38048640; PMCID: PMC10969516.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. J Gen Virol. 2024 01; 105(1).
McMillan CLD, Wijesundara DK, Choo JJY, Amarilla AA, Modhiran N, Fernando GJP, Khromykh AA, Watterson D, Young PR, Muller DA. PMID: 38271027.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18-55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. EBioMedicine. 2023 Nov; 97:104842.
Chappell KJ, Mordant FL, Amarilla AA, Modhiran N, Liang B, Li Z, Wijesundara DK, Lackenby JA, Griffin P, Bennet JK, Hensen L, Zhang W, Nguyen THO, Tran MH, Tapley P, Barnes J, Reading PC, Kedzierska K, Ranasinghe C, Subbarao K, Watterson D, Young PR, Munro TP. PMID: 37865043; PMCID: PMC10597768.
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PubMed Mentions: Fields:
Translation:
HumansCellsCTClinical Trials
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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Mol Psychiatry. 2023 Jul; 28(7):2878-2893.
Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. PMID: 36316366; PMCID: PMC10615762.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Diversity and transmission of koala retrovirus: a case study in three captive koala populations. Sci Rep. 2022 09 22; 12(1):15787.
Joyce BA, Blyton MDJ, Johnston SD, Meikle WD, Vinette Herrin K, Madden C, Young PR, Chappell KJ. PMID: 36138048; PMCID: PMC9499970.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions. Proc Natl Acad Sci U S A. 2022 08 16; 119(33):e2122680119.
Blyton MDJ, Young PR, Moore BD, Chappell KJ. PMID: 35943984; PMCID: PMC9388103.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern. Vaccine. 2022 08 12; 40(34):4929-4932.
McMillan CLD, Amarilla AA, Modhiran N, Choo JJY, Azuar A, Honeyman KE, Khromykh AA, Young PR, Watterson D, Muller DA. PMID: 35871873; PMCID: PMC9291373.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants. Front Immunol. 2022; 13:926262.
Isaacs A, Amarilla AA, Aguado J, Modhiran N, Albornoz EA, Baradar AA, McMillan CLD, Choo JJY, Idris A, Supramaniam A, McMillan NAJ, Muller DA, Young PR, Woodruff TM, Wolvetang EJ, Chappell KJ, Watterson D. PMID: 35757714; PMCID: PMC9226548.
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PubMed Mentions:
7 Fields:
Translation:
HumansCellsPHPublic Health
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Peptide-Based Vaccine against SARS-CoV-2: Peptide Antigen Discovery and Screening of Adjuvant Systems. Pharmaceutics. 2022 Apr 13; 14(4).
Shalash AO, Azuar A, Madge HYR, Modhiran N, Amarilla AA, Liang B, Khromykh AA, Hussein WM, Chappell KJ, Watterson D, Young PR, Skwarczynski M, Toth I. PMID: 35456690; PMCID: PMC9024957.
View in:
PubMed Mentions:
3
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Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. NPJ Vaccines. 2022 Jan 05; 7(1):3.
McMillan CLD, Cheung STM, Modhiran N, Barnes J, Amarilla AA, Bielefeldt-Ohmann H, Lee LYY, Guilfoyle K, van Amerongen G, Stittelaar K, Jakob V, Lebas C, Reading P, Short KR, Young PR, Watterson D, Chappell KJ. PMID: 34987159; PMCID: PMC8733011.
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PubMed Mentions:
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Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay. Vaccines (Basel). 2021 Dec 16; 9(12).
Shalash AO, Azuar A, Madge HYR, Modhiran N, Amarilla AA, Liang B, Khromykh AA, Watterson D, Young PR, Toth I, Skwarczynski M. PMID: 34960239; PMCID: PMC8705285.
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PubMed Mentions:
8
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Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. NPJ Vaccines. 2021 Nov 08; 6(1):135.
McMillan CLD, Cheung STM, Modhiran N, Barnes J, Amarilla AA, Bielefeldt-Ohmann H, Lee LYY, Guilfoyle K, van Amerongen G, Stittelaar K, Jakob V, Lebas C, Reading P, Short KR, Young PR, Watterson D, Chappell KJ. PMID: 34750396; PMCID: PMC8575991.
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PubMed Mentions:
6
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Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine. Sci Adv. 2021 Oct 29; 7(44):eabj8065.
McMillan CLD, Choo JJY, Idris A, Supramaniam A, Modhiran N, Amarilla AA, Isaacs A, Cheung STM, Liang B, Bielefeldt-Ohmann H, Azuar A, Acharya D, Kelly G, Fernando GJP, Landsberg MJ, Khromykh AA, Watterson D, Young PR, McMillan NAJ, Muller DA. PMID: 34714668; PMCID: PMC8555896.
View in:
PubMed Mentions:
20 Fields:
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Koala retrovirus genetic diversity and transmission dynamics within captive koala populations. Proc Natl Acad Sci U S A. 2021 09 21; 118(38).
Joyce BA, Blyton MDJ, Johnston SD, Young PR, Chappell KJ. PMID: 34493581; PMCID: PMC8463891.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Implications of Dengue Virus Maturation on Vaccine Induced Humoral Immunity in Mice. Viruses. 2021 09 15; 13(9).
Scott CAP, Amarilla AA, Bibby S, Newton ND, Hall RA, Hobson-Peters J, Muller DA, Chappell KJ, Young PR, Modhiran N, Watterson D. PMID: 34578424; PMCID: PMC8473161.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses. Nat Commun. 2021 06 08; 12(1):3431.
Amarilla AA, Sng JDJ, Parry R, Deerain JM, Potter JR, Setoh YX, Rawle DJ, Le TT, Modhiran N, Wang X, Peng NYG, Torres FJ, Pyke A, Harrison JJ, Freney ME, Liang B, McMillan CLD, Cheung STM, Guevara DJDC, Hardy JM, Bettington M, Muller DA, Coulibaly F, Moore F, Hall RA, Young PR, Mackenzie JM, Hobson-Peters J, Suhrbier A, Watterson D, Khromykh AA. PMID: 34103499; PMCID: PMC8187723.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. Lancet Infect Dis. 2021 10; 21(10):1383-1394.
Chappell KJ, Mordant FL, Li Z, Wijesundara DK, Ellenberg P, Lackenby JA, Cheung STM, Modhiran N, Avumegah MS, Henderson CL, Hoger K, Griffin P, Bennet J, Hensen L, Zhang W, Nguyen THO, Marrero-Hernandez S, Selva KJ, Chung AW, Tran MH, Tapley P, Barnes J, Reading PC, Nicholson S, Corby S, Holgate T, Wines BD, Hogarth PM, Kedzierska K, Purcell DFJ, Ranasinghe C, Subbarao K, Watterson D, Young PR, Munro TP. PMID: 33887208; PMCID: PMC8055208.
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Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clin Transl Immunology. 2021; 10(4):e1269.
Watterson D, Wijesundara DK, Modhiran N, Mordant FL, Li Z, Avumegah MS, McMillan CL, Lackenby J, Guilfoyle K, van Amerongen G, Stittelaar K, Cheung ST, Bibby S, Daleris M, Hoger K, Gillard M, Radunz E, Jones ML, Hughes K, Hughes B, Goh J, Edwards D, Scoble J, Pearce L, Kowalczyk L, Phan T, La M, Lu L, Pham T, Zhou Q, Brockman DA, Morgan SJ, Lau C, Tran MH, Tapley P, Villalón-Letelier F, Barnes J, Young A, Jaberolansar N, Scott CA, Isaacs A, Amarilla AA, Khromykh AA, van den Brand JM, Reading PC, Ranasinghe C, Subbarao K, Munro TP, Young PR, Chappell KJ. PMID: 33841880; PMCID: PMC8021130.
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PubMed Mentions:
29
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Assessing the potential of unmanned aerial vehicle spraying of aqueous ozone as an outdoor disinfectant for SARS-CoV-2. Environ Res. 2021 05; 196:110944.
Albert S, Amarilla AA, Trollope B, Sng JDJ, Setoh YX, Deering N, Modhiran N, Weng SH, Melo MC, Hutley N, Nandy A, Furlong MJ, Young PR, Watterson D, Grinham AR, Khromykh AA. PMID: 33647300; PMCID: PMC7908847.
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PubMed Mentions:
8 Fields:
Translation:
HumansCellsPHPublic Health
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An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2. Front Microbiol. 2021; 12:625136.
Amarilla AA, Modhiran N, Setoh YX, Peng NYG, Sng JDJ, Liang B, McMillan CLD, Freney ME, Cheung STM, Chappell KJ, Khromykh AA, Young PR, Watterson D. PMID: 33643253; PMCID: PMC7906992.
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PubMed Mentions:
25
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Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines. Vaccines (Basel). 2021 Jan 20; 9(2).
Isaacs A, Li Z, Cheung STM, Wijesundara DK, McMillan CLD, Modhiran N, Young PR, Ranasinghe C, Watterson D, Chappell KJ. PMID: 33498370; PMCID: PMC7909420.
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PubMed Mentions:
11
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The Next Generation of Influenza Vaccines: Towards a Universal Solution. Vaccines (Basel). 2021 Jan 07; 9(1).
McMillan CLD, Young PR, Watterson D, Chappell KJ. PMID: 33430278; PMCID: PMC7825669.
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PubMed Mentions:
14
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Rapid Response Subunit Vaccine Design in the Absence of Structural Information. Front Immunol. 2020; 11:592370.
Wijesundara DK, Avumegah MS, Lackenby J, Modhiran N, Isaacs A, Young PR, Watterson D, Chappell KJ. PMID: 33250897; PMCID: PMC7672035.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood. Pediatr Pulmonol. 2020 05; 55(5):1237-1245.
Brealey JC, Young PR, Sloots TP, Ware RS, Lambert SB, Sly PD, Grimwood K, Chappell KJ. PMID: 32176838.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections. Microbiology (Reading). 2020 01; 166(1):63-72.
Brealey JC, Sly PD, Young PR, Chappell KJ. PMID: 31714201.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus. Sci Transl Med. 2019 12 11; 11(522).
Hobson-Peters J, Harrison JJ, Watterson D, Hazlewood JE, Vet LJ, Newton ND, Warrilow D, Colmant AMG, Taylor C, Huang B, Piyasena TBH, Chow WK, Setoh YX, Tang B, Nakayama E, Yan K, Amarilla AA, Wheatley S, Moore PR, Finger M, Kurucz N, Modhiran N, Young PR, Khromykh AA, Bielefeldt-Ohmann H, Suhrbier A, Hall RA. PMID: 31826984.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Determinants of Zika virus host tropism uncovered by deep mutational scanning. Nat Microbiol. 2019 05; 4(5):876-887.
Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA. PMID: 30886357; PMCID: PMC6667831.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Structural and Functional Characterization of a Cross-Reactive Dengue Virus Neutralizing Antibody that Recognizes a Cryptic Epitope. Structure. 2018 01 02; 26(1):51-59.e4.
Li J, Watterson D, Chang CW, Che XY, Li XQ, Ericsson DJ, Qiu LW, Cai JP, Chen J, Fry SR, Cheung STM, Cooper MA, Young PR, Kobe B. PMID: 29249606.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children. Respirology. 2018 02; 23(2):220-227.
Brealey JC, Chappell KJ, Galbraith S, Fantino E, Gaydon J, Tozer S, Young PR, Holt PG, Sly PD. PMID: 28913912; PMCID: PMC7169064.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Sci Rep. 2017 09 11; 7(1):11130.
Jaberolansar N, Chappell KJ, Watterson D, Bermingham IM, Toth I, Young PR, Skwarczynski M. PMID: 28894111; PMCID: PMC5593926.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Angiotensin II for the Treatment of Vasodilatory Shock. N Engl J Med. 2017 08 03; 377(5):419-430.
Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, Busse LW, Altaweel L, Albertson TE, Mackey C, McCurdy MT, Boldt DW, Chock S, Young PJ, Krell K, Wunderink RG, Ostermann M, Murugan R, Gong MN, Panwar R, Hästbacka J, Favory R, Venkatesh B, Thompson BT, Bellomo R, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Deane AM, ATHOS-3 Investigators. PMID: 28528561.
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PubMed Mentions:
256 Fields:
Translation:
Humans
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Computational Identification of Antibody Epitopes on the Dengue Virus NS1 Protein. Molecules. 2017 Apr 10; 22(4).
Jones ML, Legge FS, Lebani K, Mahler SM, Young PR, Watterson D, Treutlein HR, Zeng J. PMID: 28394300; PMCID: PMC6154621.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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How Can the Health System Retain Women in HIV Treatment for a Lifetime? A Discrete Choice Experiment in Ethiopia and Mozambique. PLoS One. 2016; 11(8):e0160764.
Kruk ME, Riley PL, Palma AM, Adhikari S, Ahoua L, Arnaldo C, Belo DF, Brusamento S, Cumba LI, Dziuban EJ, El-Sadr WM, Gutema Y, Habtamu Z, Heller T, Kidanu A, Langa J, Mahagaja E, McCarthy CF, Melaku Z, Shodell D, Tsiouris F, Young PR, Rabkin M. PMID: 27551785; PMCID: PMC4994936.
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PubMed Mentions:
30 Fields:
Translation:
Humans
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Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use. Psychopharmacology (Berl). 2016 Sep; 233(17):3249-57.
Brody AL, Hubert R, Mamoun MS, Enoki R, Garcia LY, Abraham P, Young P, Mandelkern MA. PMID: 27370018; PMCID: PMC4982797.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
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Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination". Sci Transl Med. 2015 Dec 16; 7(318):318lr4.
Stacey KJ, Watterson D, Modhiran N, Young PR. PMID: 26676606.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue. Biointerphases. 2015 Dec 07; 10(4):04A305.
Robinson KJ, Coffey JW, Muller DA, Young PR, Kendall MA, Thurecht KJ, Grøndahl L, Corrie SR. PMID: 26446192.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCellsPHPublic Health
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Recent advances in the development of subunit-based RSV vaccines. Expert Rev Vaccines. 2016; 15(1):53-68.
Jaberolansar N, Toth I, Young PR, Skwarczynski M. PMID: 26506139.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation. Virol J. 2015 May 07; 12:72.
Setoh YX, Tan CS, Prow NA, Hobson-Peters J, Young PR, Khromykh AA, Hall RA. PMID: 25946997; PMCID: PMC4424586.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiol Lett. 2015 May; 362(10).
Brealey JC, Sly PD, Young PR, Chappell KJ. PMID: 25877546.
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PubMed Mentions:
59 Fields:
Translation:
Humans
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A portable approach for the surveillance of dengue virus-infected mosquitoes. J Virol Methods. 2012 Jul; 183(1):90-3.
Muller DA, Frentiu FD, Rojas A, Moreira LA, O'Neill SL, Young PR. PMID: 22575689.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCellsPHPublic Health
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Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis. J Gen Virol. 2012 Apr; 93(Pt 4):771-779.
Muller DA, Landsberg MJ, Bletchly C, Rothnagel R, Waddington L, Hankamer B, Young PR. PMID: 22238236.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. J Gen Virol. 2012 Jan; 93(Pt 1):72-82.
Watterson D, Kobe B, Young PR. PMID: 21957126.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Molecular phylogeny of edge hill virus supports its position in the yellow Fever virus group and identifies a new genetic variant. Evol Bioinform Online. 2010 Jun 15; 6:91-6.
Macdonald J, Poidinger M, Mackenzie JS, Russell RC, Doggett S, Broom AK, Phillips D, Potamski J, Gard G, Whelan P, Weir R, Young PR, Gendle D, Maher S, Barnard RT, Hall RA. PMID: 20938485; PMCID: PMC2901633.
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PubMed Mentions:
12
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In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Res. 2009 Dec; 84(3):234-41.
Kampmann T, Yennamalli R, Campbell P, Stoermer MJ, Fairlie DP, Kobe B, Young PR. PMID: 19781577.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Retroviral invasion of the koala genome. Nature. 2006 Jul 06; 442(7098):79-81.
Tarlinton RE, Meers J, Young PR. PMID: 16823453.
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PubMed Mentions:
172 Fields:
Translation:
AnimalsCells
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Determination of the disulfide bond arrangement of dengue virus NS1 protein. J Biol Chem. 2004 May 14; 279(20):20729-41.
Wallis TP, Huang CY, Nimkar SB, Young PR, Gorman JJ. PMID: 14981082.
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PubMed Mentions:
24 Fields:
Translation:
Cells
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Production of the baculovirus-expressed dengue virus glycoprotein NS1 can be improved dramatically with optimised regimes for fed-batch cultures and the addition of the insect moulting hormone, 20-Hydroxyecdysone. J Virol Methods. 2002 Aug; 105(1):87-98.
Chan LC, Young PR, Bletchly C, Reid S. PMID: 12176145.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells