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Ardehali, Reza

Title(s)Associate Professor-in-Residence, Medicine
SchoolCardiology
Phone58816
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of pericytes in scar formation following stroke and myocardial infarction
    NIH/NINDS R01NS112256Mar 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Generation of mature human embryonic stem cell-derived left ventricular cardiomyocytes for transplantation in a large animal model
    NIH/NHLBI R01HL148714Jul 15, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Exploring heterogeneity of cardiac fibroblasts to reverse fibrosis
    NIH/NHLBI DP2HL127728Sep 30, 2014 - Sep 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Butler CL, Hickey MJ, Jiang N, Zheng Y, Gjertson D, Zhang Q, Rao P, Fishbein GA, Cadeiras M, Deng MC, Banchs HL, Torre G, DeNofrio D, Eisen HJ, Kobashigawa J, Starling RC, Kfoury A, Van Bakel A, Ewald G, Balazs I, Baas AS, Cruz D, Ardehali R, Biniwale R, Kwon M, Ardehali A, Nsair A, Ray B, Reed EF. Discovery of Non-HLA Antibodies Associated with Cardiac Allograft Rejection and Development and Validation of a Non-HLA Antigen Multiplex Panel: from Bench to Bedside. Am J Transplant. 2020 Mar 17. PMID: 32185871.
      View in: PubMed
    2. Ashtari K, Nazari H, Ko H, Tebon P, Akhshik M, Akbari M, Alhosseini SN, Mozafari M, Mehravi B, Soleimani M, Ardehali R, Ebrahimi Warkiani M, Ahadian S, Khademhosseini A. Electrically conductive nanomaterials for cardiac tissue engineering. Adv Drug Deliv Rev. 2019 04; 144:162-179. PMID: 31176755.
      View in: PubMed
    3. Nguyen NB, Chen CH, Zhang Y, Zhao P, Wu BM, Ardehali R. Harnessing the versatility of PLGA nanoparticles for targeted Cre-mediated recombination. Nanomedicine. 2019 07; 19:106-114. PMID: 31026512.
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    4. Hu JR, Florido R, Lipson EJ, Naidoo J, Ardehali R, Tocchetti CG, Lyon AR, Padera RF, Johnson DB, Moslehi J. Cardiovascular toxicities associated with immune checkpoint inhibitors. Cardiovasc Res. 2019 04 15; 115(5):854-868. PMID: 30715219.
      View in: PubMed
    5. Park S, Nguyen NB, Pezhouman A, Ardehali R. Cardiac fibrosis: potential therapeutic targets. Transl Res. 2019 07; 209:121-137. PMID: 30930180.
      View in: PubMed
    6. Engel JL, Ardehali R. Sendai virus based direct cardiac reprogramming: what lies ahead? Stem Cell Investig. 2018; 5:37. PMID: 30498748.
      View in: PubMed
    7. Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Circulation. 2018 09 18; 138(12):1224-1235. PMID: 29950403.
      View in: PubMed
    8. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). PMID: 30135307.
      View in: PubMed
    9. McDonald AI, Shirali AS, Aragón R, Ma F, Hernandez G, Vaughn DA, Mack JJ, Lim TY, Sunshine H, Zhao P, Kalinichenko V, Hai T, Pelegrini M, Ardehali R, Iruela-Arispe ML. Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities. Cell Stem Cell. 2018 Aug 02; 23(2):210-225.e6. PMID: 30075129.
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    10. Villano NP, Kwon M, Ardehali R. Distal Left Main Coronary Artery Aneurysm Resection during 5-Vessel Coronary Artery Bypass Grafting. Tex Heart Inst J. 2018 04; 45(2):99-101. PMID: 29844743.
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    11. Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 03 24; 20(5):35. PMID: 29574550.
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    12. Bakir M, Jackson NJ, Han SX, Bui A, Chang E, Liem DA, Ardehali A, Ardehali R, Baas AS, Press MC, Cruz D, Deng MC, DePasquale EC, Fonarow GC, Khuu T, Kwon MH, Kubak BM, Nsair A, Phung JL, Reed EF, Schaenman JM, Shemin RJ, Zhang QJ, Tseng CH, Cadeiras M. Clinical phenomapping and outcomes after heart transplantation. J Heart Lung Transplant. 2018 08; 37(8):956-966. PMID: 29802085.
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    13. Engel JL, Ardehali R. Direct Cardiac Reprogramming: Progress and Promise. Stem Cells Int. 2018; 2018:1435746. PMID: 29731772.
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    14. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat Commun. 2018 02 21; 9(1):754. PMID: 29467410.
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    15. Banankhah P, Fishbein GA, Dota A, Ardehali R. Cardiac manifestations of PRKAG2 mutation. BMC Med Genet. 2018 01 03; 19(1):1. PMID: 29298659.
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    16. Hill JA, Ardehali R, Clarke KT, Del Zoppo GJ, Eckhardt LL, Griendling KK, Libby P, Roden DM, Sadek HA, Seidman CE, Vaughan DE. Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association. Circ Res. 2017 Jul 21; 121(3):e2-e8. PMID: 28652256.
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    17. Ranjbarvaziri S, Park S, Nguyen NB, Gilmore WB, Zhao P, Ardehali R. Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts. Genesis. 2017 08; 55(8). PMID: 28589709.
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    18. Skelton RJP, Kamp TJ, Elliott DA, Ardehali R. Biomarkers of Human Pluripotent Stem Cell-Derived Cardiac Lineages. Trends Mol Med. 2017 07; 23(7):651-668. PMID: 28576602.
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    19. Garg V, Tan W, Ardehali R, Shah J, Huynh T, Aksoy O. Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. ESC Heart Fail. 2017 Aug; 4(3):371-375. PMID: 28772042.
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    20. Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJP, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K. Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation. Cell Rep. 2017 01 03; 18(1):54-67. PMID: 27989715.
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    21. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Sci Rep. 2016 Mar 03; 6:22489. PMID: 26935567.
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    22. Skelton RJ, Brady B, Khoja S, Sahoo D, Engel J, Arasaratnam D, Saleh KK, Abilez OJ, Zhao P, Stanley EG, Elefanty AG, Kwon M, Elliott DA, Ardehali R. CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells. Stem Cell Reports. 2016 Jan 12; 6(1):95-108. PMID: 26771355.
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    23. Skelton RJ, Khoja S, Almeida S, Rapacchi S, Han F, Engel J, Zhao P, Hu P, Stanley EG, Elefanty AG, Kwon M, Elliott DA, Ardehali R. Magnetic Resonance Imaging of Iron Oxide-Labeled Human Embryonic Stem Cell-Derived Cardiac Progenitors. Stem Cells Transl Med. 2016 Jan; 5(1):67-74. PMID: 26582908.
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    24. Chen CH, Sereti KI, Wu BM, Ardehali R. Translational aspects of cardiac cell therapy. J Cell Mol Med. 2015 Aug; 19(8):1757-72. PMID: 26119413.
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    25. Almeida SO, Skelton RJ, Adigopula S, Ardehali R. Arrhythmia in stem cell transplantation. Card Electrophysiol Clin. 2015 Jun; 7(2):357-70. PMID: 26002399.
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    26. Jessup M, Ardehali R, Konstam MA, Manno BV, Mathier MA, McPherson JA, Sweitzer NK. COCATS 4 Task Force 12: Training in Heart Failure. J Am Coll Cardiol. 2015 May 05; 65(17):1866-76. PMID: 25777644.
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    27. Milin AC, Vorobiof G, Aksoy O, Ardehali R. Insights into aortic sclerosis and its relationship with coronary artery disease. J Am Heart Assoc. 2014 Sep 05; 3(5):e001111. PMID: 25193296.
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    28. Ali SR, Ranjbarvaziri S, Talkhabi M, Zhao P, Subat A, Hojjat A, Kamran P, Müller AM, Volz KS, Tang Z, Red-Horse K, Ardehali R. Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation. Circ Res. 2014 Sep 12; 115(7):625-35. PMID: 25037571.
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    29. Ali SR, Hippenmeyer S, Saadat LV, Luo L, Weissman IL, Ardehali R. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8850-5. PMID: 24876275.
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    30. Skelton RJ, Costa M, Anderson DJ, Bruveris F, Finnin BW, Koutsis K, Arasaratnam D, White AJ, Rafii A, Ng ES, Elefanty AG, Stanley EG, Pouton CW, Haynes JM, Ardehali R, Davis RP, Mummery CL, Elliott DA. SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development. Stem Cell Res. 2014 Jul; 13(1):172-9. PMID: 24968096.
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    31. Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti KI, Ardehali R, Jiang M, Mikkola HK. c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface. Dev Cell. 2013 Nov 25; 27(4):373-86. PMID: 24286824.
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    32. Kamran P, Sereti KI, Zhao P, Ali SR, Weissman IL, Ardehali R. Parabiosis in mice: a detailed protocol. J Vis Exp. 2013 Oct 06; (80). PMID: 24145664.
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    33. Ardehali R, Ali SR, Inlay MA, Abilez OJ, Chen MQ, Blauwkamp TA, Yazawa M, Gong Y, Nusse R, Drukker M, Weissman IL. Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3405-10. PMID: 23391730.
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    34. Drukker M, Tang C, Ardehali R, Rinkevich Y, Seita J, Lee AS, Mosley AR, Weissman IL, Soen Y. Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol. 2012 May 27; 30(6):531-42. PMID: 22634564.
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    35. Ardehali R, Leeper NJ, Wilson AM, Heidenreich PA. The effect of angiotensin-converting enzyme inhibitors and statins on the progression of aortic sclerosis and mortality. J Heart Valve Dis. 2012 May; 21(3):337-43. PMID: 22808835.
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    36. Blauwkamp TA, Nigam S, Ardehali R, Weissman IL, Nusse R. Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nat Commun. 2012; 3:1070. PMID: 22990866.
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    37. Ardehali R, Ali SR, Inlay MA, Mosley AR, Weissman IL. Enhanced survival of pluripotent stem cells under stressful conditions. Cell Cycle. 2011 Aug 15; 10(16):2610-1. PMID: 21791974.
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    38. Tang C, Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, Inlay MA, Ardehali R, Chavez SL, Pera RR, Behr B, Wu JC, Weissman IL, Drukker M. An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol. 2011 Aug 14; 29(9):829-34. PMID: 21841799.
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    39. Ardehali R, Inlay MA, Ali SR, Tang C, Drukker M, Weissman IL. Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3282-7. PMID: 21300885.
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    40. Kapoor JR, Gienger AL, Ardehali R, Varghese R, Perez MV, Sundaram V, McDonald KM, Owens DK, Hlatky MA, Bravata DM. Isolated disease of the proximal left anterior descending artery comparing the effectiveness of percutaneous coronary interventions and coronary artery bypass surgery. JACC Cardiovasc Interv. 2008 Oct; 1(5):483-91. PMID: 19463349.
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    41. Bravata DM, Gienger AL, McDonald KM, Sundaram V, Perez MV, Varghese R, Kapoor JR, Ardehali R, Owens DK, Hlatky MA. Systematic review: the comparative effectiveness of percutaneous coronary interventions and coronary artery bypass graft surgery. Ann Intern Med. 2007 Nov 20; 147(10):703-16. PMID: 17938385.
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    42. Leeper NJ, Ardehali R, deGoma EM, Heidenreich PA. Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival. Circulation. 2007 Aug 07; 116(6):613-8. PMID: 17664373.
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    43. Ardehali R, Nasir K, Kolandaivelu A, Budoff MJ, Blumenthal RS. Screening patients for subclinical atherosclerosis with non-contrast cardiac CT. Atherosclerosis. 2007 Jun; 192(2):235-42. PMID: 17467714.
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    44. Wilson AM, Ardehali R, Brinton TJ, Yeung AC, Vagelos R. Successful removal of a paradoxical coronary embolus using an aspiration catheter. Nat Clin Pract Cardiovasc Med. 2006 Nov; 3(11):633-6. PMID: 17063168.
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    45. Ardehali R, Reed AS, Owens C, Meininger GR, Conte JV, Hare JM. A long and bumpy road. Am J Med. 2006 Nov; 119(11):923-6. PMID: 17071156.
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    46. Ardehali R, Brinton TJ, Wilson AM, Gradman M, Vagelos RH, Lee DP. Recurrent spontaneous coronary artery dissection with transient left ventricular systolic dysfunction. Int J Cardiol. 2007 Mar 20; 116(2):e48-50. PMID: 16930750.
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    47. Wilson A, Ardehali R, Brinton TJ, Yeung AC, Lee DP. Cutting balloon inflation for drug-eluting stent underexpansion due to unrecognized coronary arterial calcification. Cardiovasc Revasc Med. 2006 Jul-Sep; 7(3):185-8. PMID: 16945827.
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    48. Michos ED, Ardehali R, Blumenthal RS, Lange RA, Ardehali H. Aspirin and clopidogrel resistance. Mayo Clin Proc. 2006 Apr; 81(4):518-26. PMID: 16610572.
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    49. Lutter G, Ardehali R, Cremer J, Bonhoeffer P. Percutaneous valve replacement: current state and future prospects. Ann Thorac Surg. 2004 Dec; 78(6):2199-206. PMID: 15561078.
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    50. Ardehali R, Shi L, Janatova J, Mohammad SF, Burns GL. The inhibitory activity of serum to prevent bacterial adhesion is mainly due to apo-transferrin. J Biomed Mater Res A. 2003 Jul 01; 66(1):21-8. PMID: 12833427.
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    51. Ardehali R, Shi L, Janatova J, Mohammad SF, Burns GL. The effect of apo-transferrin on bacterial adhesion to biomaterials. Artif Organs. 2002 Jun; 26(6):512-20. PMID: 12072107.
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    52. Ardehali R, Mohammad SF. 111Indium labeling of microorganisms to facilitate the investigation of bacterial adhesion. J Biomed Mater Res. 1993 Feb; 27(2):269-75. PMID: 8436584.
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